J. Steimer

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Clinical Pharmacokinetic/Pharmacodynamic and Physiologically based Pharmacokinetic Modeling in New Drug Development: The Capecitabine Experience

K. Blesch, R. Gieschke, Y. Tsukamoto, 2003, Investigational New Drugs.

A mathematical model for dynamics of cardiovascular drug action: Application to intravenous dihydropyridines in healthy volunteers

J. Steimer, C. Dubray, P. Francheteau, 1993, Journal of Pharmacokinetics and Biopharmaceutics.

Physiologically based pharmacokinetic study on a cyclosporin derivative, SDZ IMM 125

Ryosei Kawai, Malcolm Rowland, Jean-Louis Steimer, 1994, Journal of Pharmacokinetics and Biopharmaceutics.

Modelling the genesis and treatment of cancer: the potential role of physiologically based pharmacodynamics.

G. De Nicolao, J. Clairambault, S. Dahl, 2010, European journal of cancer.

Nonparametric maximum likelihood estimation for population pharmacokinetics, with application to cyclosporine

France Mentré, Alain Mallet, J. Steimer, 1988, Journal of Pharmacokinetics and Biopharmaceutics.

Alternative approaches to estimation of population pharmacokinetic parameters: comparison with the nonlinear mixed-effect model.

J F Boisvieux, A Mallet, J. Boisvieux, 1984, Drug metabolism reviews.

Sparse sampling for assessment of drug exposure in toxicological studies

J. Steimer, F. Mentré, P. Burtin, 1996, European Journal of Drug Metabolism and Pharmacokinetics.

Can compartment models account for nonmonotonicity in pharmacokinetics

J. Boisvieux, J. Steimer, Y. Plusquellec, 1982 .

On the dose dependency of Cyclosporin a absorption and disposition in healthy volunteers

J. Steimer, W. Niederberger, J. Reymond, 1988, Journal of Pharmacokinetics and Biopharmaceutics.

A time-lag model for pharmacokinetics of drugs subject to enterohepatic circulation.

J. Boisvieux, J. Steimer, Y. Plusquellec, 1982, Journal of pharmaceutical sciences.

Population pharmacokinetics of levodopa in patients with Parkinson's disease treated with tolcapone

J. Steimer, K. Jorga, L. Banken, 2000, Clinical pharmacology and therapeutics.

Population pharmacokinetics of tolcapone in parkinsonian patients in dose finding studies.

J. Steimer, K. Jorga, L. Banken, 2000, British journal of clinical pharmacology.

Exploratory analysis of population pharmacokinetic data from clinical trials with application to isradipine

J. Jais, B. Fertil, J. Steimer, 1991, Clinical pharmacology and therapeutics.

Sparse-Sampling Optimal Designs in Pharmacokinetics and Toxicokinetics*

France Mentré, Jean-Louis Steimer, Pascale Burtin, 1995 .

Isoniazid plasma and lymph kinetics after intravenous injection in dogs.

J. Steimer, Y. Plusquellec, M. Blanc, 1984, Arzneimittel-Forschung.

Simultaneous pharmacokinetic modeling of a drug and two metabolites: application to albendazole in sheep.

P. Galtier, M. Alvinerie, J. Steimer, 1991, Journal of pharmaceutical sciences.

Pharmacokinetic and pharmacodynamic data and models in clinical trials

J. Steimer, M. Ebelin, J. V. Bree, 2011, European Journal of Drug Metabolism and Pharmacokinetics.

Relationships Between Exposure to Saquinavir Monotherapy and Antiviral Response in HIV-Positive Patients

R. Gieschke, J. Steimer, N. Buss, 1999, Clinical pharmacokinetics.

A mathematical model of the kinetics of 5-fluorouracil and its metabolites in cancer patients

J. Steimer, R. Diasio, J. Sommadossi, 2004, Cancer Chemotherapy and Pharmacology.

Cytoplasmic and nuclear uptake of aldosterone in toad bladder: a mathematical modeling approach.

A. Venot, J. Steimer, P. Corvol, 1985, The American journal of physiology.

Effect of adrenalectomy and aldosterone on the modulation of mineralocorticoid receptors in rat kidney.

J. Steimer, P. Corvol, A. Michaud, 1981, The Journal of biological chemistry.

Modelling and Simulation in the Development and use of Anti-Cancer Agents: An Underused Tool?

France Mentré, Leon Aarons, Amy Racine, 2004, Journal of Pharmacokinetics and Pharmacodynamics.

APriori lithium dosage regimen using population characteristics of pharmacokinetic parameters

J. Steimer, A. Mallet, J. Gaillot, 1979, Journal of Pharmacokinetics and Biopharmaceutics.

Pharmacokinetic/pharmacodynamic modeling in drug development.

L B Sheiner, J L Steimer, J. Steimer, 2000, Annual review of pharmacology and toxicology.

A non-linear mathematical model for the in vivo determination of Kupffer cells number and rate of phagocytosis of radiocolloids in rats.

A. Venot, J. Boisvieux, J. Steimer, 1979, International journal of bio-medical computing.

Animal Health Modeling & Simulation Society: a new society promoting model-based approaches in veterinary pharmacology.

P. Toutain, R. Gehring, M. Fink, 2013, Journal of veterinary pharmacology and therapeutics.

Feedback Control Methods for Drug Dosage Optimisation

Jean-Louis Steimer, J. Steimer, S. Vožeh, 1985, Clinical pharmacokinetics.

Deux Methodes d’Individualisation des Posologies. Exemple du Lithium

J. Boisvieux, J. Steimer, A. Mallet, 1981 .

Incorporating physiological and biochemical mechanisms into pharmacokinetic-pharmacodynamic models: a conceptual framework.

Yves-Jacques Schneider, Svein G Dahl, Leon Aarons, 2009, Basic & clinical pharmacology & toxicology.

A semimechanistic and mechanistic population PK-PD model for biomarker response to ibandronate, a new bisphosphonate for the treatment of osteoporosis.

Timothy Goggin, Goonaseelan Pillai, Ronald Gieschke, 2004, British journal of clinical pharmacology.

Population pharmacokinetics and concentration-effect relationships of capecitabine metabolites in colorectal cancer patients.

K. Blesch, R. Gieschke, B. Reigner, 2003, British journal of clinical pharmacology.

[Mean residence time in the body. A new pharmacokinetic parameter?].

J. Steimer, A. Taburet, E. Singlas, 1986, Therapie.

An analytical solution for a class of delay-differential equations in pharmacokinetic compartment modeling☆

Jean-Louis Steimer, Yves Plusquellec, J. Steimer, 1984 .

Finite element simulation of gas transport in proximal respiratory airways: comparison with experimental data.

J. Boisvieux, J. Steimer, A. Mallet, 1981, Computers and biomedical research, an international journal.

Variability in drug therapy : description, estimation, and control : a Sandoz workshop

J. L. Steimer, Lewis B. Sheiner, Malcolm Rowland, 1985 .

Non-Linear Mixed Effects Modeling – From Methodology and Software Development to Driving Implementation in Drug Development Science

Goonaseelan Pillai, Jean-Louis Steimer, France Mentré, 2005, Journal of Pharmacokinetics and Pharmacodynamics.

The Use of Population Pharmacokinetics in Drug Development

France Mentré, Malcolm Rowland, Leon Aarons, 1996, Clinical pharmacokinetics.

[Renal clearance technic for individualizing lithium dosage in routine hospital care].

J. Steimer, R. Jouvent, E. Klinger, 1984, L'Encephale.

Modeling and Simulation in Clinical Drug Development

Frank Bretz, Jing Yu, Anna Georgieva, 2010 .

An Evaluation of the Integration of Pharmacokinetic and Pharmacodynamic Principles in Clinical Drug Development

Carl Peck, Jean-Louis Steimer, B. Reigner, 1997, Clinical pharmacokinetics.

Pharmacokinetic aspects of the sublingual administration of vincamine.

J. Steimer, J. Kantelip, R. Gomeni, 1990, Biopharmaceutics & drug disposition.

Estimands—What they are and why they are important for pharmacometricians

F. Bretz, J. Steimer, H. Schmidli, 2021, CPT: pharmacometrics & systems pharmacology.

Description of the time course of the prolactin suppressant effect of the dopamine agonist CQP201-403 by an integrated pharmacokinetic-pharmacodynamic model.

J. Steimer, J L Steimer, J. Grevel, 1986, British journal of clinical pharmacology.

Modelling Response Time Profiles in the Absence of Drug Concentrations: Definition and Performance Evaluation of the K–PD Model

R. Gieschke, R. Gieschke, J. Steimer, 2007, Journal of Pharmacokinetics and Pharmacodynamics.

Application of Sparse Sampling Approaches in Rodent Toxicokinetics: A Prospective View

J. Nedelman, J. Steimer, F. Tse, 1994 .

Pharmacometrics: Opportunity for Reducing Disease Burden in the Developing World: The Case of Africa

J. Steimer, P. Denti, N. Holford, 2013, CPT: pharmacometrics & systems pharmacology.

Practical experience and issues in designing and performing population pharmacokinetic/pharmacodynamic studies

M. Rowland, L. Aarons, L. Aarons, 2004, European Journal of Clinical Pharmacology.

Role of modelling and simulation in Phase I drug development.

L Aarons, M O Karlsson, F Mentré, 2001, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Population approaches in drug development

L Aarons, F Mentré, J L Steimer, 1994, European Journal of Clinical Pharmacology.

Prediction of Hemodynamic Responses in Hypertensive and Elderly Subjects from Healthy Volunteer Data: The Example of Intravenous Nicardipine

J. Steimer, P. Francheteau, H. Merdjan, 2002 .

Zero-order absorption and linear disposition of oral colchicine in healthy volunteers

J. Steimer, P. Francheteau, J. Scherrmann, 2004, European Journal of Clinical Pharmacology.