K. Ohtsubo

发表

Glycosylation in Cellular Mechanisms of Health and Disease

J. Marth, K. Ohtsubo, 2006, Cell.

Flagellin/Toll-like receptor 5 response was specifically attenuated by keratan sulfate disaccharide via decreased EGFR phosphorylation in normal human bronchial epithelial cells.

K. Ohtsubo, N. Taniguchi, K. Shirato, 2013, Biochemical and biophysical research communications.

A keratan sulfate disaccharide prevents inflammation and the progression of emphysema in murine models.

T. Betsuyaku, K. Ohtsubo, N. Taniguchi, 2017, American journal of physiology. Lung cellular and molecular physiology.

The interaction between Siglec-15 and tumor-associated sialyl-Tn antigen enhances TGF-β secretion from monocytes/macrophages through the DAP12-Syk pathway.

K. Ohtsubo, N. Taniguchi, R. Takamiya, 2013, Glycobiology.

N-Glycosylation modulates the membrane sub-domain distribution and activity of glucose transporter 2 in pancreatic beta cells.

K. Ohtsubo, N. Taniguchi, H. Korekane, 2013, Biochemical and biophysical research communications.

Loss of αl,6‐fucosyltransferase inhibits chemical‐induced hepatocellular carcinoma and tumorigenesis by down‐regulating several cell signaling pathways

K. Ohtsubo, J. Gu, T. Isaji, 2015, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Influence of SIGLEC9 polymorphisms on COPD phenotypes including exacerbation frequency

P. Paré, E. Silverman, A. Gemma, 2017, Respirology.

Studies on the structure-function relationship of the HNK-1 associated glucuronyltransferase, GlcAT-P, by computer modeling and site-directed mutagenesis.

K. Ohtsubo, S. Oka, T. Kawasaki, 2000, Journal of biochemistry.

Glyco-Predisposing Factor of Diabetes

K. Ohtsubo, 2015 .

ST6Gal-I Restrains CD22-Dependent Antigen Receptor Endocytosis and Shp-1 Recruitment in Normal and Pathogenic Immune Signaling

J. Marth, K. Ohtsubo, B. E. Collins, 2006, Molecular and Cellular Biology.

Physiological relevance of protein-glycosylation to pathogenesis of diabetes

K. Ohtsubo, N. Taniguchi, 2014 .

Disease-associated glycans on cell surface proteins.

K. Ohtsubo, J. Gu, N. Taniguchi, 2016, Molecular aspects of medicine.

Critical functions of N-glycans in L-selectin-mediated lymphocyte homing and recruitment

J. Marth, K. Ohtsubo, K. Khoo, 2007, Nature Immunology.

Glyco-redox, a link between oxidative stress and changes of glycans: Lessons from research on glutathione, reactive oxygen and nitrogen species to glycobiology.

Keiichiro Suzuki, K. Ohtsubo, N. Taniguchi, 2016, Archives of biochemistry and biophysics.

N-acetylglucosaminyltransferase (GnT) assays using fluorescent oligosaccharide acceptor substrates: GnT-III, IV, V, and IX (GnT-Vb).

K. Ohtsubo, N. Taniguchi, H. Korekane, 2013, Methods in molecular biology.

Influence of SIGLEC 9 polymorphisms on COPD phenotypes including exacerbation 1 frequency 2 3

P. Paré, E. Silverman, A. Gemma, 2016 .

Binding of langerin/CD207 to keratan sulfate disaccharide, Gal (6SO3) β1, 4-GlcNAc (6SO3) and its triangle derivative in vitro and in vivo: possible drug targets for COPD (chronic obstructive pulmonary disease)

Naoyuki Taniguchi, Tomoko Betsuyaku, Bernd Lepenies, 2014 .

Life-Style Related Disease and Aging

K. Ohtsubo, Kazuro Furukawa, N. Taniguchi, 2019, Glycoscience: Basic Science to Applications.

Loss of a 1,6-fucosyltransferase inhibits chemical-induced hepatocellular carcinoma and tumorigenesis by down-regulating several cell signaling pathways

K. Ohtsubo, J. Gu, T. Isaji, 2020 .

Mannosyl (Alpha-1,3-)-Glycoprotein Beta-1,4-N-Acetylglucosaminyltransferase, Isozyme A,B (MGAT4A,B)

K. Ohtsubo, N. Taniguchi, 2014 .

Dietary and Genetic Control of Glucose Transporter 2 Glycosylation Promotes Insulin Secretion in Suppressing Diabetes

J. Marth, K. Ohtsubo, M. Takeuchi, 2005, Cell.

Sugar Chains

K. Ohtsubo, N. Taniguchi, Tadashi Suzuki, 2015, Springer Japan.

Pathway to diabetes through attenuation of pancreatic beta cell glycosylation and glucose transport

J. Marth, K. Ohtsubo, J. Olefsky, 2011, Nature Medicine.

Core fucose and bisecting GlcNAc, the direct modifiers of the N-glycan core: their functions and target proteins.

K. Ohtsubo, N. Taniguchi, Motoko Takahashi, 2009, Carbohydrate research.

Identification of Ectonucleotide Pyrophosphatase/Phosphodiesterase 3 (ENPP3) as a Regulator of N-Acetylglucosaminyltransferase GnT-IX (GnT-Vb)*

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2013, The Journal of Biological Chemistry.

Physiological and glycomic characterization of N-acetylglucosaminyltransferase-IVa and -IVb double deficient mice.

J. Marth, K. Ohtsubo, A. Dell, 2010, Glycobiology.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, K. Ohtsubo, 2013, Cellular and Molecular Life Sciences.

Essential role of RGS-PX1/sorting nexin 13 in mouse development and regulation of endocytosis dynamics

Nan Tang, Phuong Ma, J. Marth, 2006, Proceedings of the National Academy of Sciences.

Colonization of distant organs by tumor cells generating circulating homotypic clusters adaptive to fluid shear stress

K. Ohtsubo, K. Iwamoto, Y. Nakachi, 2021, Scientific Reports.

Integrated approach toward the discovery of glyco‐biomarkers of inflammation‐related diseases

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2012, Annals of the New York Academy of Sciences.

Loss of Siglec-14 reduces the risk of chronic obstructive pulmonary disease exacerbation

V. Nizet, A. Gemma, A. Varki, 2013, Cellular and Molecular Life Sciences.

Association of serum interleukin‐27 with the exacerbation of chronic obstructive pulmonary disease

A. Gemma, K. Ohtsubo, N. Taniguchi, 2014, Physiological reports.

Hypoxic regulation of glycosylation via the N-acetylglucosamine cycle

K. Ohtsubo, N. Taniguchi, K. Shirato, 2010, Journal of clinical biochemistry and nutrition.

Initiation of Protein O Glycosylation by the Polypeptide GalNAcT-1 in Vascular Biology and Humoral Immunity

Klaus Ley, Lawrence A. Tabak, Patrick Schaerli, 2007, Molecular and Cellular Biology.

A single dose of lipopolysaccharide into mice with emphysema mimics human chronic obstructive pulmonary disease exacerbation as assessed by micro-computed tomography.

Naoyuki Taniguchi, Tomoko Betsuyaku, Manabu Ueno, 2013, American journal of respiratory cell and molecular biology.

Mass Isotopomer Analysis of Metabolically Labeled Nucleotide Sugars and N- and O-Glycans for Tracing Nucleotide Sugar Metabolisms*

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2013, Molecular & Cellular Proteomics.

Sensitivity of Heterozygous α1,6-Fucosyltransferase Knock-out Mice to Cigarette Smoke-induced Emphysema

T. Betsuyaku, K. Ohtsubo, N. Taniguchi, 2012, The Journal of Biological Chemistry.

Glycoredox: New Paradigm for Glycosylation and Redox Signaling Research

K. Ohtsubo, N. Taniguchi, R. Takamiya, 2015 .

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

Galectin-lattice sustains function of cationic amino acid transporter and insulin secretion of pancreatic β cells.

K. Ohtsubo, Y. Ando, M. Tasaki, 2020, Journal of biochemistry.

α1,6-Fucosyltransferase (Fut8) is implicated in vulnerability to elastase-induced emphysema in mice and a possible non-invasive predictive marker for disease progression and exacerbations in chronic obstructive pulmonary disease (COPD).

T. Betsuyaku, M. Nishimura, A. Gemma, 2012, Biochemical and biophysical research communications.

N-glycans of SREC-I (scavenger receptor expressed by endothelial cells): essential role for ligand binding, trafficking and stability.

M. Tajiri, Y. Wada, K. Ohtsubo, 2012, Glycobiology.

Simultaneous determination of nucleotide sugars with ion-pair reversed-phase HPLC.

K. Ohtsubo, N. Taniguchi, S. Kitazume, 2010, Glycobiology.

N-glycans of SREC-I (scavenger receptor expressed by endothelial cells): essential role for ligand binding, trafficking and stability.

M. Tajiri, Y. Wada, K. Ohtsubo, 2012, Glycobiology.