E. Meffre

发表

Immunoglobulin heavy chain expression shapes the B cell receptor repertoire in human B cell development.

M. Nussenzweig, E. Meffre, M. Milili, 2001, The Journal of clinical investigation.

Predominant Autoantibody Production by Early Human B Cell Precursors

M. Nussenzweig, E. Meffre, H. Wardemann, 2003, Science.

AIRE expression controls the peripheral selection of autoreactive B cells

C. Cunningham-Rundles, E. Meffre, P. Utz, 2019, Science Immunology.

Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning.

Michel C Nussenzweig, Hedda Wardemann, M. Nussenzweig, 2008, Journal of immunological methods.

DNA repair protein Ku80 suppresses chromosomal aberrations and malignant transformation

Thomas Ried, Michel C. Nussenzweig, M. Nussenzweig, 2000, Nature.

Lentiviral-mediated gene therapy restores B cell tolerance in Wiskott-Aldrich syndrome patients.

E. Meffre, F. Candotti, M. C. Castiello, 2015, The Journal of clinical investigation.

CD19 controls Toll-like receptor 9 responses in human B cells.

İ. Reisli, J. Franco, C. Cunningham-Rundles, 2016, The Journal of allergy and clinical immunology.

Deletion of immunoglobulin β in developing B cells leads to cell death

M. Nussenzweig, E. Meffre, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Specific peripheral B cell tolerance defects in patients with multiple sclerosis.

D. Hafler, E. Meffre, K. Herold, 2013, The Journal of clinical investigation.

intraepithelial lymphocytes + gut δ γ early T- and B-cell development and a reduction in T-cell receptor Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of

M. Nussenzweig, E. Meffre, A. Carrier, 2013 .

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor γδ+ gut intraepithelial lymphocytes

M. Nussenzweig, E. Meffre, A. Carrier, 2001 .

Autosomal primary immunodeficiencies affecting human bone marrow B‐cell differentiation

E. Meffre, C. Schiff, B. Lemmers, 2000, Immunological reviews.

Correction of autoimmune IL2RA mutations in primary human T cells using non-viral genome targeting

Channabasavaiah B. Gurumurthy, Rolen M. Quadros, A. May, 2017 .

Reprogramming human T cell function and specificity with non-viral genome targeting

Channabasavaiah B. Gurumurthy, Rolen M. Quadros, A. Ashworth, 2017, bioRxiv.

Protective antiviral antibody responses in a mouse model of influenza virus infection require TACI.

E. Meffre, M. Cancro, R. Bram, 2011, The Journal of clinical investigation.

B-Cell Chronic Lymphocytic Leukemia (B-CLL) Cells Express Antibodies Reactive with Antigenic Epitopes Expressed on the Surface of Common Bacteria.

E. Meffre, N. Chiorazzi, M. Ferrarini, 2006 .

Immunoepidemiology of Immune Dysfunction

E. Meffre, P. Krause, N. Ruddle, 2019, Immunoepidemiology.

In Situ B Cell-Mediated Immune Responses and Tubulointerstitial Inflammation in Human Lupus Nephritis

E. Meffre, R. Quigg, T. Utset, 2011, The Journal of Immunology.

Inflammasome activation in infected macrophages drives COVID-19 pathology

J. Lieberman, Y. Kluger, M. Nussenzweig, 2021, Nature.

B-cell biology, tolerance, and autoantibodies

E. Meffre, J. Anolik, Jennifer L. Barnas, 2021, Lahita's Systemic Lupus Erythematosus.

A novel humanized mouse model with significant improvement of class-switched, antigen-specific antibody production.

E. Meffre, A. Murphy, R. Flavell, 2017, Blood.

Malaria-susceptible West African Children Atypical Memory B Cells in the V Gene Repertoires of Classical And

E. Meffre, J. Skinner, M. Waisberg, 2022 .

The V Gene Repertoires of Classical and Atypical Memory B Cells in Malaria-Susceptible West African Children

E. Meffre, J. Skinner, M. Waisberg, 2015, The Journal of Immunology.

Autoantibody selection and production in early human life.

E. Meffre, J. Salmon, 2007, The Journal of clinical investigation.

Rituximab does not reset defective early B cell tolerance checkpoints.

E. Meffre, K. Herold, C. Massad, 2016, The Journal of clinical investigation.

DOCK8 deficient patients have a breakdown in peripheral B cell tolerance and defective regulatory T cells

R. Geha, W. Al-Herz, T. Chatila, 2014 .

Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells.

R. Geha, W. Al-Herz, T. Chatila, 2014, The Journal of allergy and clinical immunology.

Partial RAG deficiency in humans induces dysregulated peripheral lymphocyte development and humoral tolerance defect with accumulation of T-bet+ B cells

S. Pittaluga, V. Kanderova, L. Notarangelo, 2022, Nature Immunology.

Gain-of-function STAT1 mutations are associated with PD-L1 overexpression and a defect in B-cell survival.

S. Holland, E. Meffre, I. Kang, 2013, The Journal of allergy and clinical immunology.

PTPN22 inhibition resets defective human central B cell tolerance.

E. Meffre, R. Flavell, T. Strowig, 2016, Science immunology.

PTPN22 inhibition resets defective human central B cell tolerance

E. Meffre, R. Flavell, T. Strowig, 2016, Science Immunology.

PTPN 22 inhibition resets defective human central B cell tolerance

E. Meffre, R. Flavell, Christopher, 2016 .

Signaling lymphocytic activation molecule (SLAM)/SLAM-associated protein pathway regulates human B-cell tolerance.

C. Cunningham-Rundles, S. Tangye, J. Church, 2014, The Journal of allergy and clinical immunology.

Signaling Lymphocyte Activated Molecule (SLAM)/SLAM-associated Protein (SAP) Pathway Regulates Human B-cell Tolerance

J. Church, E. Meffre, K. Nichols, 2014 .

A novel ATM mutation associated with elevated atypical lymphocyte populations, hyper-IgM, and cutaneous granulomas.

E. Meffre, P. Reynolds, E. Gelfand, 2019, Clinical immunology.

Corrigendum to ‘Efficient generation of monoclonal antibodies from single human B cells by single cell RT-PCR and expression vector cloning’[J. Immunol. Methods 329 (2008) 112−124]

M. Nussenzweig, E. Meffre, T. Tiller, 2008 .

Defective B cell tolerance checkpoints in systemic lupus erythematosus

V. Pascual, M. Nussenzweig, E. Meffre, 2005, The Journal of experimental medicine.

Brief Report: Defective Early B Cell Tolerance Checkpoints in Sjögren's Syndrome Patients

E. Meffre, J. Gottenberg, A. Korganow, 2017, Arthritis & rheumatology.

Loss of FOXP3 function causes expansion of two pools of autoreactive T cells in patients with IPEX syndrome

E. Meffre, M. Roncarolo, R. Bacchetta, 2022, bioRxiv.

Title: Loss of FOXP3 function causes expansion of two pools of autoreactive 1 T cells in patients with IPEX syndrome.

E. Meffre, M. Roncarolo, R. Bacchetta, 2022 .

TACI triggers immunoglobulin class switching by activating B cells through the adaptor protein MyD88

R. Döffinger, J. Casanova, A. Plebani, 2010, Nature immunology.

Relapsing and remitting severe hypoglycemia due to a monoclonal anti-insulin antibody heralding a case of multiple myeloma.

W. Hagopian, E. Meffre, P. Marks, 2012, The Journal of clinical endocrinology and metabolism.

IgM+IgD+CD27+ B cells are markedly reduced in IRAK-4-, MyD88-, and TIRAP- but not UNC-93B-deficient patients.

J. Casanova, C. Picard, E. Meffre, 2012, Blood.

Cell surface expression of surrogate light chain (ΨL) in the absence of μ on human pro‐B cell lines and normal pro‐B cells

E. Meffre, C. Schiff, J. Aubaniac, 1996, European journal of immunology.

Deletion of immunoglobulin beta in developing B cells leads to cell death.

M. Nussenzweig, E. Meffre, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Defective Early B Cell Tolerance Checkpoints in Patients With Systemic Sclerosis Allow the Production of Self Antigen–Specific Clones

E. Meffre, S. Glauzy, C. Massad, 2021, Arthritis & rheumatology.

Defective B cell tolerance in adenosine deaminase deficiency is corrected by gene therapy.

E. Meffre, A. Aiuti, H. Morbach, 2012, The Journal of clinical investigation.

B cell depletion or absence does not impede anti-tumor activity of PD-1 inhibitors

E. Meffre, H. Kluger, M. Tomayko, 2019, Journal of Immunotherapy for Cancer.

Accumulation of Antigen‐Driven Lymphoproliferations in Complement Receptor 2/CD21−/low B Cells From Patients With Sjögren's Syndrome

E. Meffre, J. James, K. Sivils, 2018, Arthritis & rheumatology.

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

E. Meffre, M. Shlomchik, S. Kleinstein, 2015, Immunity.

Expansion of autoreactive unresponsive CD21-/low B cells in Sjögren's syndrome-associated lymphoproliferation.

E. Meffre, D. Klatzmann, F. Joly, 2013, Arthritis and rheumatism.

Wiskott–Aldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans☆

M. van der Burg, M. V. van Zelm, G. Driessen, 2014, Journal of autoimmunity.

Antibody Repertoire Surrogate Light Chains Display a Unique Circulating Human B Cells That Express

M. Nussenzweig, E. Meffre, Michael Chiorazzi, 2001 .

Accumulation of peripheral autoreactive B cells in the absence of functional human regulatory T cells.

H. Ochs, T. Torgerson, C. Cancrini, 2013, Blood.

Mice lacking the CCR9 CC-chemokine receptor show a mild impairment of early T- and B-cell development and a reduction in T-cell receptor gammadelta(+) gut intraepithelial lymphocytes.

M. Nussenzweig, E. Meffre, A. Carrier, 2001, Blood.

CD40 ligand and MHC class II expression are essential for human peripheral B cell tolerance

C. Cunningham-Rundles, H. Ochs, E. Meffre, 2007, The Journal of experimental medicine.

Immune dysregulation in human subjects with heterozygous germline mutations in CTLA4

J. B. Oliveira, J. Hughes, J. McElwee, 2014, Science.

Reprogramming human T cell function and specificity with non-viral genome targeting

A. Ashworth, A. May, J. Weissman, 2017, bioRxiv.

Activation-induced cytidine deaminase (AID) is required for B-cell tolerance in humans

F. Rieux-Laucat, L. Notarangelo, J. Walter, 2011, Proceedings of the National Academy of Sciences.

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.

J. Casanova, C. Picard, E. Meffre, 2008, Immunity.

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

Eric O Long, K. Shianna, D. Goldstein, 2012, The New England journal of medicine.

Human DEF6 deficiency underlies an immunodeficiency syndrome with systemic autoimmunity and aberrant CTLA-4 homeostasis

J. Orange, E. Meffre, W. Pickl, 2019, Nature Communications.

Antibody regulation of B cell development

M. Nussenzweig, E. Meffre, R. Casellas, 2000, Nature Immunology.

A de novo nonsense mutation in the tyrosine kinase lyn in a patient with an early onset autoinflammatory phenotype

E. Meffre, T. Fleisher, S. Rosenzweig, 2014, Pediatric Rheumatology.

Unmutated and mutated chronic lymphocytic leukemias derive from self-reactive B cell precursors despite expressing different antibody reactivity.

E. Meffre, H. Wardemann, N. Chiorazzi, 2005, The Journal of clinical investigation.

Genomic Instability in Mice Lacking Histone H2AX

Michel C. Nussenzweig, Lino Tessarollo, Bernardo Reina-San-Martin, 2002, Science.

The PTPN22 allele encoding an R620W variant interferes with the removal of developing autoreactive B cells in humans.

P. Gregersen, C. Abraham, E. Meffre, 2011, The Journal of clinical investigation.

Bruton's Tyrosine Kinase Is Essential for Human B Cell Tolerance

C. Cunningham-Rundles, E. Meffre, H. Wardemann, 2004, The Journal of experimental medicine.

RAG Represents a Widespread Threat to the Lymphocyte Genome

D. Schatz, L. Cowell, E. Meffre, 2015, Cell.

Circulating Human CD27−IgA+ Memory B Cells Recognize Bacteria with Polyreactive Igs

M. V. van Zelm, J. V. van Dongen, E. Meffre, 2015, The Journal of Immunology.

The First B-Cell Tolerance Checkpoint in Mice and Humans: Control by AID.

E. Meffre, G. Kelsoe, M. Kuraoka, 2018, Advances in immunology.

Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.

L. Notarangelo, J. Walter, W. Al-Herz, 2015, Immunity.

Transcriptional repressor Blimp-1 promotes CD8(+) T cell terminal differentiation and represses the acquisition of central memory T cell properties.

E. Meffre, S. Kaech, K. Calame, 2009, Immunity.

The transmembrane activator TACI triggers immunoglobulin class switching by activating B cells through the adaptor MyD88

R. Döffinger, J. Casanova, A. Plebani, 2010, Nature Immunology.

Somatic Hypermutation Shapes the Antibody Repertoire of Memory B Cells in Humans

Michel C. Nussenzweig, A. Fischer, M. Nussenzweig, 2001, The Journal of experimental medicine.

REAP: A platform to identify autoantibodies that target the human exoproteome

E. Meffre, A. Ring, Elise M. N. Ferré, 2021, bioRxiv.

A humanized mouse model of chronic COVID-19

Y. Kluger, M. Nussenzweig, A. Iwasaki, 2021, Nature Biotechnology.

Viral replication in human macrophages enhances an inflammatory cascade and interferon driven chronic COVID-19 in humanized mice.

J. Lieberman, Y. Kluger, M. Nussenzweig, 2021, bioRxiv : the preprint server for biology.

Progress and challenges for treating Type 1 diabetes.

C. Cotsapas, E. Meffre, K. Herold, 2016, Journal of autoimmunity.

Mutation of NLRC4 causes a syndrome of enterocolitis and autoinflammation

E. Meffre, T. Boggon, Murim Choi, 2014, Nature Genetics.

Germline hypomorphic CARD11 mutations in severe atopic disease

J. McElwee, Yuan Zhang, E. Meffre, 2017, Nature Genetics.

A non-XLA primary deficiency causes the earliest known defect of B cell differentiation in humans: a comparison with an XLA case.

F. Ledeist, E. Meffre, C. Schiff, 1997, Immunology letters.

Transitional B cells in quiescent SLE: An early checkpoint imprinted by IFN.

E. Meffre, J. Liesveld, V. Poindron, 2019, Journal of autoimmunity.

Survival of human lymphoma cells requires B-cell receptor engagement by self-antigens

L. Staudt, A. Rosenwald, W. Chan, 2015, Proceedings of the National Academy of Sciences.

Surrogate Light Chain Expressing Human Peripheral B Cells Produce Self-reactive Antibodies

M. Nussenzweig, E. Meffre, H. Wardemann, 2004, The Journal of experimental medicine.

Antigen Receptor Engagement Turns off the V(D)J Recombination Machinery in Human Tonsil B Cells

J. Banchereau, M. Nussenzweig, E. Meffre, 1998, The Journal of experimental medicine.

mTOR intersects antibody-inducing signals from TACI in marginal zone B cells

J. Lloreta, M. Pybus, M. Juan, 2017, Nature Communications.

B Cell Development Is Arrested at the Immature B Cell Stage in Mice Carrying a Mutation in the Cytoplasmic Domain of Immunoglobulin β

Shiaoching Gong, K. Rajewsky, M. Nussenzweig, 2001, The Journal of experimental medicine.

Continued RAG expression in late stages of B cell development and no apparent re-induction after immunizion

Heikyung Suh, M. Nussenzweig, E. Meffre, 1999, Nature.

Essential Role of STAT3 in Postnatal Survival and Growth Revealed by Mice Lacking STAT3 Serine 727 Phosphorylation

J. Darnell, D. Levy, E. Meffre, 2004, Molecular and Cellular Biology.

Impaired ATM activation in B cells is associated with bone resorption in rheumatoid arthritis

Ruth R. Montgomery, E. Meffre, E. Gelfand, 2019, Science Translational Medicine.

Patients with common variable immunodeficiency with autoimmune cytopenias exhibit hyperplastic yet inefficient germinal center responses

C. Cunningham-Rundles, K. Sullivan, E. Meffre, 2019, The Journal of allergy and clinical immunology.

Maturational characteristics of HIV-specific antibodies in viremic individuals.

T. Chun, A. Fauci, E. Meffre, 2016, JCI insight.

Response: common variable immunodeficiency patients with increased CD21 −/lo B cells suffer from altered receptor editing and defective central B-cell tolerance

C. Cunningham-Rundles, E. Meffre, N. Romberg, 2011 .

Complement receptor 2/CD21- human naive B cells contain mostly autoreactive unresponsive clones.

C. Cunningham-Rundles, E. Meffre, J. Buckner, 2010, Blood.

Individual CD34+CD38lowCD19-CD10- progenitor cells from human cord blood generate B lymphocytes and granulocytes.

W. Vainchenker, E. Meffre, C. Schiff, 1997, Blood.

Positive and negative selection shape the human naive B cell repertoire

K. Schwarz, A. Schulz, E. Meffre, 2021, The Journal of clinical investigation.

Early B cell tolerance defects in neuromyelitis optica favour anti-AQP4 autoantibody production.

E. Meffre, S. Kleinstein, J. Bennett, 2019, Brain : a journal of neurology.

B-cell tolerance checkpoints in health and autoimmunity.

Hedda Wardemann, E. Meffre, H. Wardemann, 2008, Current opinion in immunology.

Deficiency of base excision repair enzyme NEIL3 drives increased predisposition to autoimmunity.

Toshiro K. Ohsumi, L. Notarangelo, R. Geha, 2016, The Journal of clinical investigation.

Disease-associated CTNNBL1 mutation impairs somatic hypermutation by decreasing nuclear AID.

J. Lupski, R. Gibbs, D. Schatz, 2020, The Journal of clinical investigation.

Self-reactive VH4-34–expressing IgG B cells recognize commensal bacteria

J. Casanova, C. Picard, S. Holland, 2017, The Journal of experimental medicine.

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

M. van der Burg, L. Notarangelo, J. Walter, 2016, The Journal of clinical investigation.

CVID-associated TACI mutations affect autoreactive B cell selection and activation.

R. Geha, C. Cunningham-Rundles, E. Meffre, 2013, The Journal of clinical investigation.

Impaired early B cell tolerance in patients with rheumatoid arthritis

E. Meffre, J. Samuels, Yen-shing Ng, 2005, The Journal of Experimental Medicine.

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

E. Meffre, 2011, Annals of the New York Academy of Sciences.

Impaired early B cell tolerance in patients with rheumatoid arthritis

E. Meffre, J. Samuels, Yen-shing Ng, 2005, The Journal of experimental medicine.

Potential roles of activation-induced cytidine deaminase in promotion or prevention of autoimmunity in humans

E. Meffre, A. Durandy, T. Cantaert, 2013, Autoimmunity.

A humanized mouse model of chronic COVID-19 to evaluate disease mechanisms and treatment options

Y. Kluger, M. Nussenzweig, A. Iwasaki, 2021, Research square.

B Lymphocyte–Induced Maturation Protein-1 Contributes to Intestinal Mucosa Homeostasis by Limiting the Number of IL-17–Producing CD4+ T Cells

S. Targan, E. Meffre, J. Silva, 2012, The Journal of Immunology.

Producing CD 4 − IL-17 Homeostasis by Limiting the Number of Protein-1 Contributes to Intestinal Mucosa Induced Maturation − B Lymphocyte

S. Targan, E. Meffre, J. Silva, 2012 .

HSC extrinsic sex-related and intrinsic autoimmune disease-related human B-cell variation is recapitulated in humanized mice.

E. Meffre, M. Sykes, R. Goland, 2017, Blood advances.

Immunoglobulin Heavy Chain Variable Region Gene Replacement as a Mechanism for Receptor Revision in Rheumatoid Arthritis Synovial Tissue B Lymphocytes

E. Meffre, N. Chiorazzi, R. Furie, 2000, The Journal of experimental medicine.

Impaired TLR9 responses in B cells from patients with systemic lupus erythematosus.

E. Meffre, A. Soley, Sophie Jung, 2018, JCI insight.

Antigen-mediated regulation in monoclonal gammopathies and myeloma.

D. Hose, B. Barlogie, N. Munshi, 2018, JCI insight.

A rapid method for targeted modification and screening of recombinant bacterial artificial chromosome.

N. Heintz, E. Meffre, Z. Misulovin, 2001, Journal of immunological methods.

Interferon deficiency can lead to severe COVID

A. Iwasaki, E. Meffre, 2020, Nature.

Impaired B‐cell tolerance checkpoints promote the development of autoimmune diseases and pathogenic autoantibodies

E. Meffre, K. O’Connor, 2019, Immunological reviews.

Developmental partitioning of SYK and ZAP70 prevents autoimmunity and cancer.

W. Chan, A. Pandey, N. Heisterkamp, 2021, Molecular cell.

Circulating Human B Cells That Express Surrogate Light Chains Display a Unique Antibody Repertoire1

M. Nussenzweig, E. Meffre, Michael Chiorazzi, 2001, The Journal of Immunology.

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Oxidation

E. Meffre, N. Chiorazzi, K. Rai, 2008, Molecular medicine.

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

J. Stéen, E. Meffre, H. Wardemann, 2013, The Journal of experimental medicine.

Expansion Of Circulating T Follicular Helper Cells In CVID Patients With Autoimmune Cytopenias

C. Cunningham-Rundles, E. Meffre, N. Romberg, 2014 .

Dynamic phosphatase-recruitment controls B-cell selection and oncogenic signaling

E. Meffre, A. Marson, K. Kume, 2023, bioRxiv.

Circulating human B cells that express surrogate light chains and edited receptors

L. Staudt, M. Nussenzweig, C. Cunningham-Rundles, 2000, Nature Immunology.

TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development.

S. Rosengren, R. Geha, C. Cunningham-Rundles, 2015, The Journal of allergy and clinical immunology.

Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

D. Burton, S. Kazer, A. Shalek, 2017, The Journal of experimental medicine.

Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

D. Burton, S. Kazer, A. Shalek, 2017, The Journal of experimental medicine.

TACI Isoforms Regulate Ligand Binding and Receptor Function

C. Cunningham-Rundles, E. Meffre, L. Radigan, 2018, Front. Immunol..

RAG expression in B cells in secondary lymphoid tissues.

M. Nussenzweig, E. Meffre, F. Papavasiliou, 1999, Cold Spring Harbor symposia on quantitative biology.

Role of BCR affinity in T cell–dependent antibody responses in vivo

M. Nussenzweig, E. Meffre, M. Roederer, 2002, Nature Immunology.

Isoform-specific knockdown of long and intermediate prolactin receptors interferes with evolution of B-cell neoplasms

E. Meffre, Xiwei Wu, W. Stohl, 2023, Communications Biology.

A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early proB cell stage.

F. Ledeist, E. Meffre, C. Schiff, 1996, The Journal of clinical investigation.

Reprogramming human T cell function and specificity with non-viral genome targeting

J. Weissman, M. Leonetti, S. Hughes, 2018, Nature.

Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients

Ann M. Stowe, L. Cowell, E. Meffre, 2016, Acta Neuropathologica.

Autoantibodies are highly prevalent in non–SARS-CoV-2 respiratory infections and critical illness

J. Carette, K. Nadeau, E. Meffre, 2023, JCI insight.

Autoantibodies targeting cytokines and connective tissue disease autoantigens are common in acute non-SARS-CoV-2 infections.

J. Carette, K. Nadeau, E. Meffre, 2022, Research square.

Constitutively active Lyn kinase causes a cutaneous small vessel vasculitis and liver fibrosis syndrome

S. Pittaluga, E. Meffre, S. Hewitt, 2022, Nature Communications.

MUTATIONS IN THE TYROSINE-PROTEIN KINASE LYN CAUSE AN EARLY-ONSET NEUTROPHILIC VASCULITIS SYNDROME

E. Meffre, S. Hewitt, D. Kleiner, 2017 .

Monoclonal IgG antibodies generated from joint-derived B cells of RA patients have a strong bias toward citrullinated autoantigen recognition

E. Meffre, H. Wardemann, L. Klareskog, 2018 .

Human B Cell Tolerance and Its Failure in Rheumatoid Arthritis

E. Meffre, J. Samuels, Yen-shing Ng, 2005, Annals of the New York Academy of Sciences.

High-throughput identification of autoantibodies that target the human exoproteome

E. Meffre, A. Ring, Elise M. N. Ferré, 2022, Cell reports methods.

A Novel AICDA Splice-Site Mutation in Two Siblings with HIGM2 Permits Somatic Hypermutation but Abrogates Mutational Targeting

E. Meffre, H. Morbach, H. Girschick, 2022, Journal of Clinical Immunology.

Autoreactivity in naïve human fetal B cells is associated with commensal bacteria recognition

E. Meffre, Agata Bielecka, Noah W. Palm, 2020, Science.

Germline genetic variants are associated with development of insulin-dependent diabetes in cancer patients treated with immune checkpoint inhibitors

E. Meffre, K. Herold, Yariv Aizenbud, 2023, Journal for ImmunoTherapy of Cancer.

mTOR intersects antibody-inducing signals from TACI in marginal zone B cells

S. Serrano, J. Lloreta, M. Pybus, 2017, Nature Communications.

Inflammation-independent defective early B cell tolerance checkpoints in rheumatoid arthritis.

E. Meffre, J. Samuels, Yen-shing Ng, 2011, Arthritis and rheumatism.

Differential proliferative responses in subsets of human CD28+ cells delineated by BB27 mAb.

E. Meffre, L. Boumsell, C. Gouttefangeas, 1994, International Immunology.

Inflammasome activation in infected macrophages drives COVID-19 pathology

J. Lieberman, Y. Kluger, M. Nussenzweig, 2022 .

Reprogramming human T cell function and specificity with non-viral genome targeting

Jonathan S. Weissman, Alan Ashworth, Antoni Ribas, 2017, Nature.

Impaired early B-cell tolerance in patients with rheumatoid arthritis

E. Meffre, Yen-shing Ng, J. Samuels, 2005 .

A human non-XLA immunodeficiency disease characterized by blockage of B cell development at an early pro-B cell stage

F. Ledeist, E. Meffre, C. Schiff, 1997 .

Correction: Novel in vitro booster vaccination to rapidly generate antigen-specific human monoclonal antibodies

D. Burton, S. Kazer, A. Shalek, 2017, The Journal of experimental medicine.

The establishment of early B cell tolerance in humans: lessons from primary immunodeficiency diseases

E. Meffre, 2011, Annals of the New York Academy of Sciences.

Decreased somatic hypermutation induces an impaired peripheral B cell tolerance checkpoint.

M. van der Burg, L. Notarangelo, J. Walter, 2016, The Journal of clinical investigation.

Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation.

E. Meffre, M. Shlomchik, S. Kleinstein, 2015, Immunity.

Activation-Induced Cytidine Deaminase Expression in Human B Cell Precursors Is Essential for Central B Cell Tolerance.

L. Notarangelo, J. Walter, W. Al-Herz, 2015, Immunity.

TNF receptor superfamily member 13b (TNFRSF13B) hemizygosity reveals transmembrane activator and CAML interactor haploinsufficiency at later stages of B-cell development.

S. Rosengren, R. Geha, C. Cunningham-Rundles, 2015, The Journal of allergy and clinical immunology.

CVID-associated TACI mutations affect autoreactive B cell selection and activation.

R. Geha, C. Cunningham-Rundles, E. Meffre, 2013, The Journal of clinical investigation.

Chronic Lymphocytic Leukemia Cells Recognize Conserved Epitopes Associated with Apoptosis and Catabolic Chemical Modifications

E. Meffre, N. Chiorazzi, K. Rai, 2008 .

Polyreactive Monoclonal Antibodies Synthesized by Some B-CLL Cells Recognize Specific Antigens on Viable and Apoptotic T Cells.

E. Meffre, N. Chiorazzi, K. Rai, 2006 .

Defective B cell tolerance checkpoints in systemic lupus erythematosus

V. Pascual, M. Nussenzweig, E. Meffre, 2005, The Journal of experimental medicine.

Cold urticaria, immunodeficiency, and autoimmunity related to PLCG2 deletions.

Eric O Long, K. Shianna, D. Goldstein, 2012, The New England journal of medicine.

WiskotteAldrich Syndrome protein deficiency perturbs the homeostasis of B-cell compartment in humans

G. Driessen, E. Meffre, M. C. Castiello, 2014 .

TLR9 ligand sequestration by chemokine CXCL4 negatively affects central B cell tolerance

A. Hoischen, L. Staudt, E. Meffre, 2023, The Journal of experimental medicine.

IRAK-4- and MyD88-dependent pathways are essential for the removal of developing autoreactive B cells in humans.

J. Casanova, C. Picard, E. Meffre, 2008, Immunity.