C. Guerra

发表

A synthetic lethal interaction between K-Ras oncogenes and Cdk4 unveils a therapeutic strategy for non-small cell lung carcinoma.

M. Barbacid, Marta Puyol, Alberto Martin, 2010, Cancer cell.

Pancreatic Ductal Deletion of Hnf1b Disrupts Exocrine Homeostasis, Leads to Pancreatitis, and Facilitates Tumorigenesis

C. Guerra, M. Gannon, A. Couvelard, 2019, Cellular and molecular gastroenterology and hepatology.

p38alpha MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation.

M. Barbacid, C. Guerra, M. Pasparakis, 2007, Nature genetics.

Proceedings from the 2009 genetic syndromes of the Ras/MAPK pathway: From bedside to bench and back

Alcino J. Silva, G. Nolan, A. Balmain, 2010, American journal of medical genetics. Part A.

Tumor induction by an endogenous K-ras oncogene is highly dependent on cellular context.

Manuel Serrano, Pierre Dubus, M. Barbacid, 2003, Cancer cell.

Mechanisms underlying cognitive deficits in a mouse model for Costello Syndrome are distinct from other RASopathy mouse models

S. Kushner, C. Guerra, D. Jaarsma, 2017, Scientific Reports.

Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.

C. Guerra, P. Vargiu, S. Ortega, 2016, Human molecular genetics.

RAF1 kinase activity is dispensable for KRAS/p53 mutant lung tumor progression.

M. Barbacid, C. Guerra, D. Santamaría, 2021, Cancer cell.

Loss of Apc allows phenotypic manifestation of the transforming properties of an endogenous K-ras oncogene in vivo

Julie A. Wilkins, M. Barbacid, A. Cole, 2006, Proceedings of the National Academy of Sciences.

KRAS4A induces metastatic lung adenocarcinomas in vivo in the absence of the KRAS4B isoform

M. Barbacid, C. Guerra, M. Drosten, 2021, Proceedings of the National Academy of Sciences.

Lack of EGFR catalytic activity in hepatocytes improves liver regeneration following DDC‐induced cholestatic injury by promoting a pro‐restorative inflammatory response

Á. Valverde, C. Guerra, P. Bragado, 2022, The Journal of pathology.

Combined Inhibition of FOSL-1 and YAP Using siRNA-Lipoplexes Reduces the Growth of Pancreatic Tumor

M. Barbacid, C. Guerra, Á. González-Fernández, 2022, Cancers.

Common Telomere Changes during In Vivo Reprogramming and Early Stages of Tumorigenesis

M. Blasco, C. Guerra, M. Serrano, 2017, Stem cell reports.

KSR induces RAS‐independent MAPK pathway activation and modulates the efficacy of KRAS inhibitors

T. Pons, M. Barbacid, C. Guerra, 2022, Molecular oncology.

The impact of the genetic background in the Noonan syndrome phenotype induced by K-RasV14I

C. Guerra, A. J. Schuhmacher, Isabel Hernández-Porras, 2015, Rare diseases.

Genetic analysis of Ras signalling pathways in cell proliferation, migration and survival

M. Barbacid, C. Guerra, M. Drosten, 2010, The EMBO journal.

Tumour biology: Senescence in premalignant tumours

M. Barbacid, A. Efeyan, C. Guerra, 2005, Nature.

Dynamic Regulation of Expression of KRAS and Its Effectors Determines the Ability to Initiate Tumorigenesis in Pancreatic Acinar Cells

M. Barbacid, C. Guerra, L. Bouwens, 2021, Cancer Research.

EGF receptor signaling is essential for k-ras oncogene-driven pancreatic ductal adenocarcinoma.

M. Barbacid, C. Guerra, C. Navas, 2012, Cancer cell.

Complete Regression of Advanced Pancreatic Ductal Adenocarcinomas upon Combined Inhibition of EGFR and C-RAF.

R. Rabadán, M. Barbacid, M. Hidalgo, 2019, Cancer cell.

Upregulation of miR-21 by Ras in vivo and its role in tumor growth

M. Ceccarelli, P. Zoppoli, M. Barbacid, 2011, Oncogene.

Genetically engineered mouse models of pancreatic adenocarcinoma

M. Barbacid, C. Guerra, 2013, Molecular oncology.

What we have learned about pancreatic cancer from mouse models.

M. Barbacid, D. Tuveson, P. A. Pérez-Mancera, 2012, Gastroenterology.

Exploiting oncogene-induced replicative stress for the selective killing of Myc-driven tumors

M. Barbacid, M. Hidalgo, C. Guerra, 2011, Nature Structural &Molecular Biology.

Definitive evidence for Club cells as progenitors for mutant Kras/Trp53‐deficient lung cancer

M. Barbacid, D. Schuppan, C. Guerra, 2021, International journal of cancer.

Mouse Models of RAS-Induced Tumors and Developmental Disorders

M. Barbacid, C. Guerra, 2014 .

The epigenetic regulators Bmi1 and Ring1B are differentially regulated in pancreatitis and pancreatic ductal adenocarcinoma

F. Real, M. Barbacid, C. Guerra, 2009, The Journal of pathology.

Genetically Engineered Mouse Models of K-Ras-Driven Lung and Pancreatic Tumors: Validation of Therapeutic Targets.

M. Barbacid, C. Guerra, M. Drosten, 2018, Cold Spring Harbor perspectives in medicine.

Noonan syndrome: lessons learned from genetically modified mouse models

C. Guerra, Raquel García-Medina, A. J. Schuhmacher, 2017, Expert review of endocrinology & metabolism.

A mouse model for Costello syndrome reveals an Ang II-mediated hypertensive condition.

M. Barbacid, C. Guerra, X. Bustelo, 2008, The Journal of clinical investigation.

H-Ras and K-Ras Oncoproteins Induce Different Tumor Spectra When Driven by the Same Regulatory Sequences.

M. Barbacid, C. Guerra, M. Drosten, 2017, Cancer research.

Modeling RASopathies with Genetically Modified Mouse Models.

C. Guerra, Isabel Hernández-Porras, 2017, Methods in molecular biology.

DYRK1B-dependent autocrine-to-paracrine shift of Hedgehog signaling by mutant RAS

M. Barbacid, C. Guerra, T. Shimokawa, 2010, Nature Structural &Molecular Biology.

Galectin-1 drives pancreatic carcinogenesis through stroma remodeling and Hedgehog signaling activation.

C. Guerra, R. Hwang, H. Gabius, 2014, Cancer research.

Targeting galectin-1 inhibits pancreatic cancer progression by modulating tumor–stroma crosstalk

G. Rabinovich, C. Guerra, R. Hwang, 2018, Proceedings of the National Academy of Sciences.

c-RAF Ablation Induces Regression of Advanced Kras/Trp53 Mutant Lung Adenocarcinomas by a Mechanism Independent of MAPK Signaling.

M. Barbacid, M. Hidalgo, C. Guerra, 2018, Cancer cell.

K‐RasV14I‐induced Noonan syndrome predisposes to tumour development in mice

Beatriz Jiménez, C. Guerra, Raquel García-Medina, 2016, The Journal of pathology.

The acinar regulator Gata6 suppresses KrasG12V-driven pancreatic tumorigenesis in mice

F. Real, C. Guerra, E. Pau, 2015, Gut.

Utilizing past and present mouse systems to engineer more relevant pancreatic cancer models

C. Guerra, M. Pasca di Magliano, D. Principe, 2014, Front. Physiol..

p38α MAP kinase is essential in lung stem and progenitor cell proliferation and differentiation

M. Barbacid, C. Guerra, M. Pasparakis, 2007, Nature Genetics.

Chronic pancreatitis is essential for induction of pancreatic ductal adenocarcinoma by K-Ras oncogenes in adult mice.

M. Barbacid, P. Dubus, C. Guerra, 2007, Cancer cell.

Protein farnesyltransferase in embryogenesis, adult homeostasis, and tumor development.

M. Barbacid, P. Casey, P. Dubus, 2005, Cancer cell.

Chronic pancreatitis and lipomatosis are associated with defective function of ciliary genes in pancreatic ductal cells.

C. Guerra, P. Vargiu, S. Ortega, 2016, Human molecular genetics.

Saa3 is a key mediator of the protumorigenic properties of cancer-associated fibroblasts in pancreatic tumors

A. Trumpp, R. Rabadán, M. Barbacid, 2018, Proceedings of the National Academy of Sciences.

Pancreatitis-induced inflammation contributes to pancreatic cancer by inhibiting oncogene-induced senescence.

M. Barbacid, C. Guerra, M. Serrano, 2011, Cancer cell.

Loss of p27Kip1 promotes metaplasia in the pancreas via the regulation of Sox9 expression

C. Guerra, O. Bachs, A. Besson, 2015, Oncotarget.

Tumor regression and resistance mechanisms upon CDK4 and RAF1 inactivation in KRAS/P53 mutant lung adenocarcinomas

M. Barbacid, C. Guerra, D. Santamaría, 2020, Proceedings of the National Academy of Sciences.

K-RasV14I recapitulates Noonan syndrome in mice

Manuel Desco, Lorena Cussó, M. Barbacid, 2014, Proceedings of the National Academy of Sciences.

RASless MEFs as a Tool to Study RAS-Dependent and RAS-Independent Functions.

M. Barbacid, C. Guerra, M. Drosten, 2021, Methods in molecular biology.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

F. Real, M. Barbacid, C. Heeschen, 2014, Gastroenterology.

Parp‐1 genetic ablation in Ela–myc mice unveils novel roles for Parp‐1 in pancreatic cancer

C. Guerra, J. Yélamos, M. Iglesias, 2014, The Journal of pathology.

Soluble AXL is a novel blood marker for early detection of pancreatic ductal adenocarcinoma and differential diagnosis from chronic pancreatitis

A. Carrato, C. Guerra, Helena Cristóbal, 2021, EBioMedicine.

Germline expression of H‐RasG12V causes neurological deficits associated to Costello syndrome

C. Guerra, A. Barco, A. J. Schuhmacher, 2009, Genes, brain, and behavior.

Stromal disrupting effects of nab-paclitaxel in pancreatic cancer

Y Quijano, M. Barbacid, M. Hidalgo, 2013, British Journal of Cancer.

Establishment of Pancreatic Cancer-Derived Tumor Organoids and Fibroblasts From Fresh Tissue.

A. Carrato, C. Guerra, C. Lechuga, 2023, Journal of Visualized Experiments.

Kras oncogene ablation prevents resistance in advanced lung adenocarcinomas

M. Barbacid, F. Al-Shahrour, F. Mulero, 2023, The Journal of clinical investigation.