Jen‐Shin Song

发表

Discovery of non-glycoside sodium-dependent glucose co-transporter 2 (SGLT2) inhibitors by ligand-based virtual screening.

Yi-Hui Peng, C. Chen, Y. Chao, 2010, Journal of medicinal chemistry.

DBPR108, a novel dipeptidyl peptidase-4 inhibitor with antihyperglycemic activity.

C. Chen, Y. Chao, Jen‐Shin Song, 2021, Life sciences.

Discovery and structure-activity relationships of phenyl benzenesulfonylhydrazides as novel indoleamine 2,3-dioxygenase inhibitors.

Y. Chao, Su-Ying Wu, Jian-Sung Wu, 2014, Bioorganic & medicinal chemistry letters.

Identification of Substituted Naphthotriazolediones as Novel Tryptophan 2,3-Dioxygenase (TDO) Inhibitors through Structure-Based Virtual Screening.

Yi-Hui Peng, A. Yueh, J. Hsu, 2015, Journal of medicinal chemistry.

Phenyl Benzenesulfonylhydrazides Exhibit Selective Indoleamine 2,3-Dioxygenase Inhibition with Potent in Vivo Pharmacodynamic Activity and Antitumor Efficacy.

Yi-Hui Peng, Y. Chao, Su-Ying Wu, 2016, Journal of medicinal chemistry.

Fast-forwarding hit to lead: aurora and epidermal growth factor receptor kinase inhibitor lead identification.

Santhosh Kumar Chittimalla, Yi-Hui Peng, H. Hsieh, 2010, Journal of medicinal chemistry.

Synthesis and evaluation of 3-ylideneoxindole acetamides as potent anticancer agents.

Lie-Chwen Lin, Jen‐Shin Song, J. Liao, 2015, European journal of medicinal chemistry.

Homology modeling of DFG-in FMS-like tyrosine kinase 3 (FLT3) and structure-based virtual screening for inhibitor identification

Yung Chang Hsu, H. Hsieh, J. Hsu, 2015, Scientific Reports.

A cell-based high-throughput screen for epidermal growth factor receptor pathway inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2008, Analytical biochemistry.

Ligand efficiency based approach for efficient virtual screening of compound libraries.

H. Hsieh, J. Hsu, Szu-Huei Wu, 2014, European journal of medicinal chemistry.

Drug-like property optimization: Discovery of orally bioavailable quinazoline-based multi-targeted kinase inhibitors.

H. Hsieh, J. Hsu, M. Coumar, 2020, Bioorganic chemistry.

Protective Effect of CXCR4 Antagonist CX807 in a Rat Model of Hemorrhagic Stroke

Jen‐Shin Song, Seong-Jin Yu, Kak‐Shan Shia, 2020, International journal of molecular sciences.

Synthesis of (E)-oxindolylidene acetate using tandem palladium-catalyzed Heck and alkoxycarbonylation reactions.

Jen‐Shin Song, Wei-Jen Lin, Kak‐Shan Shia, 2016, Organic & biomolecular chemistry.

Protein Kinase FA/GSK‐3 Phosphorylates on Ser235‐Pro and Ser404‐Pro that Are Abnormally Phosphorylated in Alzheimer's Disease Brain

Jen‐Shin Song, Jau-Song Yu, Shiaw‐Der Yang, 1993, Journal of neurochemistry.

N-Indolylglycosides bearing modifications at the glucose C6-position as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Y. Chao, Szu-Huei Wu, 2016, Bioorganic & medicinal chemistry.

Development and application of a fluorescent glucose uptake assay for the high-throughput screening of non-glycoside SGLT2 inhibitors.

Y. Chao, Chieh-Jui Hsieh, Szu-Huei Wu, 2015, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A high-throughput cell-based screening for L858R/T790M mutant epidermal growth factor receptor inhibitors.

H. Hsieh, T. Lien, Y. Chao, 2012, Anticancer research.

SynthesisandBiologicalActivitiesof2-Amino-1-arylidenaminoImidazolesasOrallyActiveAnticancer Agents

Chi-Hung Lin, C. Chen, Y. Chao, 2010 .

Synthesis and biological activities of 2-amino-1-arylidenamino imidazoles as orally active anticancer agents.

Chi-Hung Lin, C. Chen, Y. Chao, 2010, Journal of medicinal chemistry.

A Potent, Selective, and Orally Bioavailable HCV NS5A Inhibitor for Treatment of Hepatitis C Virus: (S)-1-((R)-2-(Cyclopropanecarboxamido)-2-phenylacetyl)-N-(4-phenylthiazol-2-yl)pyrrolidine-2-carboxamide.

A. Yueh, Y. Chao, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

BPR0C261 is a novel orally active antitumor agent with antimitotic and anti‐angiogenic activities

Chi-Hung Lin, C. Chen, Y. Chao, 2011, Cancer science.

Pharmacological Induction of Human Fetal Globin Gene in Hydroxyurea-Resistant Primary Adult Erythroid Cells

Y. Chao, Jen‐Shin Song, Y. Chou, 2015, Molecular and Cellular Biology.

Stem cell mobilizers targeting chemokine receptor CXCR4: renoprotective application in acute kidney injury.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2015, Journal of medicinal chemistry.

Synthesis and biological evaluation of N-glucosyl indole derivatives as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Y. Chao, Szu-Huei Wu, 2019, Bioorganic chemistry.

Identification of an oxime-containing C-glucosylarene as a potential inhibitor of sodium-dependent glucose co-transporter 2.

C. Chen, Y. Chao, Szu-Huei Wu, 2018, European journal of medicinal chemistry.

Synthesis and biological evaluation of novel C-aryl d-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitors.

Szu-Huei Wu, Jen‐Shin Song, P. Liang, 2013, Bioorganic & medicinal chemistry.

Unique sulfur-aromatic interactions contribute to the binding of potent imidazothiazole indoleamine 2,3-dioxygenase inhibitors.

Yi-Hui Peng, Su-Ying Wu, Jen‐Shin Song, 2020, Journal of medicinal chemistry.

A Novel CXCR4 Antagonist CX549 Induces Neuroprotection in Stroke Brain

C. Chen, Jen‐Shin Song, Seong-Jin Yu, 2017, Cell transplantation.

A highly selective and potent CXCR4 antagonist for hepatocellular carcinoma treatment

Jen‐Shin Song, Yunching Chen, Yi-Yu Ke, 2021, Proceedings of the National Academy of Sciences.

Characterization, Dynamics, and Mechanism of CXCR4 Antagonists on a Constitutively Active Mutant.

Reed E S Harrison, Jen‐Shin Song, D. Morikis, 2019, Cell chemical biology.

Function-oriented development of CXCR4 antagonists as selective human immunodeficiency virus (HIV)-1 entry inhibitors.

H. Hsieh, Jen‐Shin Song, Yu-Wei Liu, 2015, Journal of medicinal chemistry.

Bromomethylthioindole Inspired Carbazole Hybrids as Promising Class of Anti-MRSA Agents.

Jen‐Shin Song, Jinq-chyi Lee, Yu-Wei Liu, 2016, ACS medicinal chemistry letters.

Chemical interference with DSIF complex formation lowers synthesis of mutant huntingtin gene products and curtails mutant phenotypes

Jen‐Shin Song, Tzu-Hao Cheng, Chia-Rung Liu, 2022, Proceedings of the National Academy of Sciences of the United States of America.

Protective Effect of CXCR4 Antagonist DBPR807 against Ischemia-Reperfusion Injury in a Rat and Porcine Model of Myocardial Infarction: Potential Adjunctive Therapy for Percutaneous Coronary Intervention

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2022, International journal of molecular sciences.

Discovery of novel N-β-D-xylosylindole derivatives as sodium-dependent glucose cotransporter 2 (SGLT2) inhibitors for the management of hyperglycemia in diabetes.

C. Chen, Y. Chao, Chieh-Jui Hsieh, 2011, Journal of medicinal chemistry.

4-Bromophenylhydrazinyl benzenesulfonylphenylureas as indoleamine 2,3-dioxygenase inhibitors with in vivo target inhibition and anti-tumor efficacy.

Y. Chao, Su-Ying Wu, Jen‐Shin Song, 2018, Bioorganic chemistry.

Fluorine-18 isotope labeling for positron emission tomography imaging. Direct evidence for DBPR211 as a peripherally restricted CB1 inverse agonist.

Jen‐Shin Song, Chung-Shan Yu, Kak‐Shan Shia, 2019, Bioorganic & medicinal chemistry.

Total synthesis of landomycins Q and R and related core structures for exploration of the cytotoxicity and antibacterial properties

Jen‐Shin Song, Kak‐Shan Shia, K. K. Mong, 2021, RSC advances.

(2S,4S)-1-[2-(1,1-dimethyl-3-oxo-3-pyrrolidin-1-yl-propylamino)acetyl]-4-fluoro-pyrrolidine-2-carbonitrile: a potent, selective, and orally bioavailable dipeptide-derived inhibitor of dipeptidyl peptidase IV.

C. Chen, Xin Chen, Y. Chao, 2010, Bioorganic & medicinal chemistry letters.

Identification of a potent 5-phenyl-thiazol-2-ylamine-based inhibitor of FLT3 with activity against drug resistance-conferring point mutations.

C. Chen, Y. Chao, J. Hsu, 2015, European journal of medicinal chemistry.

Design, synthesis and anticancer evaluation of β-carboline-1-one hydantoins.

Jen‐Shin Song, Jinq-chyi Lee, Chun-Hsu Yao, 2019, Future medicinal chemistry.

Design and synthesis of BPR1K653 derivatives targeting the back pocket of Aurora kinases for selective isoform inhibition.

H. Hsieh, Jen‐Shin Song, C. Shih, 2018, European journal of medicinal chemistry.

Synthesis and structure-activity relationship of 2-aminobenzophenone derivatives as antimitotic agents.

H. Hsieh, Jen‐Shin Song, Chung-Ming Chang, 2002, Journal of medicinal chemistry.

Synthesis and biological evaluation of N-heterocyclic indolyl glyoxylamides as orally active anticancer agents.

Chi-Hung Lin, C. Chen, Jen‐Shin Song, 2003, Journal of medicinal chemistry.

Bioisosteric replacement of the pyrazole 5-aryl moiety of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide (SR141716A). A novel series of alkynylthiophenes as potent and selective cannabinoid-1 receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Journal of medicinal chemistry.

Generation of ligand-based pharmacophore model and virtual screening for identification of novel tubulin inhibitors with potent anticancer activity.

Ping-Chiang Lyu, Mohane Selvaraj Coumar, Yu-Sheng Chao, 2009, Journal of medicinal chemistry.

Discovery of 1-(2,4-dichlorophenyl)-N-(piperidin-1-yl)-4-((pyrrolidine-1-sulfonamido)methyl)-5-(5-((4-(trifluoromethyl)phenyl)ethynyl)thiophene-2-yl)-1H-pyrazole-3-carboxamide as a novel peripherally restricted cannabinoid-1 receptor antagonist with significant weight-loss efficacy in diet-induced o

Y. Chao, Jen‐Shin Song, T. Yeh, 2013, Journal of medicinal chemistry.

trans‐Stilbene C‐Glycosides: Synthesis by a Microwave‐Assisted Heck Reaction and Evaluation of the SGLT‐2 Inhibitory Activity

Szu-Huei Wu, Jen‐Shin Song, Chun‐Cheng Lin, 2017 .

Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design.

Yi-Hui Peng, Su-Ying Wu, Jen‐Shin Song, 2021, European journal of medicinal chemistry.

Important Hydrogen Bond Networks in Indoleamine 2,3-Dioxygenase 1 (IDO1) Inhibitor Design Revealed by Crystal Structures of Imidazoleisoindole Derivatives with IDO1.

Su-Ying Wu, Jian-Sung Wu, Yi-Hui Peng, 2016, Journal of medicinal chemistry.

Artificial intelligence approach fighting COVID-19 with repurposing drugs

Huey-Kang Sytwu, Wen-Hsing Lin, Szu-Huei Wu, 2020, Biomedical Journal.

Dual inhibition of topoisomerase I and tubulin polymerization by BPR0Y007, a novel cytotoxic agent.

H. Hsieh, Jen‐Shin Song, J. Liou, 2003, Biochemical pharmacology.

A novel flavivirus entry inhibitor, BP34610, discovered through high-throughput screening with dengue reporter viruses.

C. Chen, A. Yueh, Szu-Huei Wu, 2019, Antiviral research.

Discovery and Synthesis of a Pyrimidine-Based Aurora Kinase Inhibitor to Reduce Levels of MYC Oncoproteins

C. Chen, Jen‐Shin Song, C. Shih, 2021, Journal of medicinal chemistry.

Harnessing CXCR4 antagonists in stem cell mobilization, HIV infection, ischemic diseases, and oncology

Jen‐Shin Song, Yi-Yu Ke, Kak‐Shan Shia, 2018, Medicinal research reviews.

Discovery of BPR1K871, a quinazoline based, multi-kinase inhibitor for the treatment of AML and solid tumors: Rational design, synthesis, in vitro and in vivo evaluation

Yung Chang Hsu, C. Chen, J. Hsu, 2016, Oncotarget.

Antiangiogenic activities and cisplatin-combined antitumor activities of BPR0L075.

H. Hsieh, C. Chen, Y. Chao, 2010, Anticancer research.

Substituted 4-carboxymethylpyroglutamic acid diamides as potent and selective inhibitors of fibroblast activation protein.

Xin Chen, Y. Chao, Jen‐Shin Song, 2010, Journal of medicinal chemistry.

Discovery of Potential Neuroprotective Agents against Paclitaxel-Induced Peripheral Neuropathy

C. Chen, Jen‐Shin Song, Jinq-chyi Lee, 2022, Journal of medicinal chemistry.

Comparative study between deep learning and QSAR classifications for TNBC inhibitors and novel GPCR agonist discovery

Jen-Shin Song, Lun K Tsou, Shiu-Hwa Yeh, 2020, Scientific Reports.

Cyclic modulation of cross-linking interactions of microtubule-associated protein-2 with actin and microtubules by protein kinase FA

Jen‐Shin Song, W. Chan, Shiaw‐Der Yang, 1993, Journal of protein chemistry.

BPR0C305, an orally active microtubule-disrupting anticancer agent

Chi-Hung Lin, C. Chen, Y. Chao, 2013, Anti-cancer drugs.

Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists.

Jen‐Shin Song, Kun-Yi Hsin, Kak‐Shan Shia, 2022, Bioorganic chemistry.

Bioisosteric replacement of the pyrazole 3-carboxamide moiety of rimonabant. A novel series of oxadiazoles as CB1 cannabinoid receptor antagonists.

Y. Chao, Jen‐Shin Song, Kak‐Shan Shia, 2008, Organic & biomolecular chemistry.

Synthesis and biological evaluation of novel C-indolylxylosides as sodium-dependent glucose co-transporter 2 inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2012, European journal of medicinal chemistry.

Design, Synthesis, and Evaluation of Thiazolidine-2,4-dione Derivatives as a Novel Class of Glutaminase Inhibitors.

C. Chen, Szu-Huei Wu, Jen‐Shin Song, 2017, Journal of medicinal chemistry.

Tau protein kinase I/GSK-3Β/kinase FA in heparin phosphorylates tau on Ser199, Thr231, Ser235, Ser262, Ser369, and Ser400 sites phosphorylated in Alzheimer disease brain

Jen‐Shin Song, S. Yang, J. S. Song, 1995, Journal of protein chemistry.

Discovery of 1‐(2,4‐Dichlorophenyl)‐4‐ethyl‐5‐(5‐(2‐(4‐(trifluoromethyl)phenyl)ethynyl)thiophen‐2‐yl)‐N‐(piperidin‐1‐yl)‐1H‐pyrazole‐3‐carboxamide as a Potential Peripheral Cannabinoid‐1 Receptor Inverse Agonist

Y. Chao, Jen‐Shin Song, T. Yeh, 2010, ChemMedChem.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors (GISTs) and Acute Myeloid Leukemia (AML).

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

Identification of a Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Gastrointestinal Stromal Tumors and Acute Myeloid Leukemia.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019 .

Synthesis and biological evaluation of 2-amino-1-thiazolyl imidazoles as orally active anticancer agents

Chi-Hung Lin, C. Chen, T. Lien, 2012, Investigational new drugs.

Design, synthesis, and anticancer evaluation of 1-benzo[1,3]dioxol-5-yl-3-N-fused heteroaryl indoles.

Szu-Huei Wu, Jen‐Shin Song, Mine-Hsine Wu, 2023, Molecular diversity.

Identification of the ATP·Mg-dependent protein phosphatase activator (Fa) as a synapsin I kinase that inhibits cross-linking of synapsin I with brain microtubules

Jen‐Shin Song, W. Chan, Shiaw‐Der Yang, 1992, Journal of protein chemistry.

Effects of boschnaloside from Boschniakia rossica on dysglycemia and islet dysfunction in severely diabetic mice through modulating the action of glucagon-like peptide-1.

Lie-Chwen Lin, C. Chen, Jen‐Shin Song, 2019, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Discovery of tetrasubstituted thiophenes as Cisd2 activators: A potential novel therapeutic option in nonalcoholic fatty liver disease.

Jen‐Shin Song, Chi-Hui Tsai, Yi-Yu Ke, 2023, European journal of medicinal chemistry.

Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus.

A. Yueh, Y. Chao, Szu-Huei Wu, 2013, Antiviral research.

Discovery of Conformational Control Inhibitors Switching off the Activated c-KIT and Targeting a Broad Range of Clinically Relevant c-KIT Mutants.

Yi-Hui Peng, C. Chen, Su-Ying Wu, 2019, Journal of medicinal chemistry.

Discovery of Novel Stem Cell Mobilizers That Target the CXCR4 Receptor

C. Chen, Y. Chao, Su-Ying Wu, 2012, ChemMedChem.

Discovery of 3-phenyl-1H-5-pyrazolylamine derivatives containing a urea pharmacophore as potent and efficacious inhibitors of FMS-like tyrosine kinase-3 (FLT3).

C. Chen, Y. Chao, J. Hsu, 2013, Bioorganic & medicinal chemistry.

Discovery of 2-[5-(4-chloro-phenyl)-1-(2,4-dichloro-phenyl)-4-ethyl-1H-pyrazol-3-yl]-1,5,5-trimethyl-1,5-dihydro-imidazol-4-thione (BPR-890) via an active metabolite. A novel, potent and selective cannabinoid-1 receptor inverse agonist with high antiobesity efficacy in DIO mice.

Y. Chao, Jen‐Shin Song, T. Yeh, 2009, Journal of medicinal chemistry.

Analysis of structure-activity relationship of indol-3-yl-N-phenylcarbamic amides as potent STING inhibitors.

Jen‐Shin Song, Liuh-Yow Chen, C. Tung, 2023, Bioorganic & Medicinal Chemistry.