J. Cechetto

发表

Experimental Screening of Dihydrofolate Reductase Yields a “Test Set” of 50,000 Small Molecules for a Computational Data-Mining and Docking Competition

Nadine H. Elowe, E. Brown, J. E. Blanchard, 2005, Journal of biomolecular screening.

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.

E. Brown, J. Cechetto, Michela Zolli-Juran, 2003, Bioorganic & medicinal chemistry letters.

An Image-Based High-Content Screening Assay for Compounds Targeting Intracellular Leishmania donovani Amastigotes in Human Macrophages

A. Genovesio, J. Cechetto, E. Chatelain, 2012, PLoS neglected tropical diseases.

Discovery of Q203, a potent clinical candidate for the treatment of tuberculosis

Se Yeon Kim, R. Wintjens, J. Cechetto, 2013, Nature Medicine.

Discovery of 3,4-dihydropyrimidin-2(1H)-ones with inhibitory activity against HIV-1 replication.

Sung-Jun Han, Wonyoung So, Peter Sommer, 2012, Bioorganic & medicinal chemistry letters.

Small-molecule screening made simple for a difficult target with a signaling nucleic acid aptamer that reports on deaminase activity.

Abdellah Allali-Hassani, Razvan Nutiu, Nadine H Elowe, 2006, Angewandte Chemie.

High-content imaging of Mycobacterium tuberculosis-infected macrophages: an in vitro model for tuberculosis drug discovery.

J. Cechetto, P. Brodin, T. Christophe, 2010, Future medicinal chemistry.

Special FocuS: TuberculoSiS

J. Cechetto, P. Brodin, T. Christophe, 2010 .

Immunoelectron microscopy provides evidence that tumor necrosis factor receptor-associated protein 1 (TRAP-1) is a mitochondrial protein which also localizes at specific extramitochondrial sites.

J. Cechetto, R. Gupta, Radhey S. Gupta, 2000, Experimental cell research.

Pyrido[1,2-a]pyrimidines anti-infectieuses

A. Genovesio, J. Cechetto, D. Fenistein, 2011 .

A mitochondrial ketogenic enzyme regulates its gene expression by association with the nuclear hormone receptor PPARα

J. Cechetto, J. Capone, R. Rachubinski, 1998, The EMBO journal.

Localization of Mitochondrial 60-kD Heat Shock Chaperonin Protein (Hsp60) in Pituitary Growth Hormone Secretory Granules and Pancreatic Zymogen Granules

J. Cechetto, B. Soltys, Radhey S. Gupta, 2000, Journal of Histochemistry and Cytochemistry.

Multicopy suppressors for novel antibacterial compounds reveal targets and drug efflux susceptibility.

E. Brown, J. Cechetto, Michela Zolli-Juran, 2004, Chemistry & biology.

Identification and characterization of a novel hepatitis B virus pregenomic RNA encapsidation inhibitor.

J. Cechetto, S. Yoon, A. König, 2020, Antiviral research.

Discovery of carbohybrid-based 2-aminopyrimidine analogues as a new class of rapid-acting antimalarial agents using image-based cytological profiling assay.

J. Cechetto, L. Ayong, M. Liuzzi, 2014, Journal of medicinal chemistry.

A novel 3,4-dihydropyrimidin-2(1H)-one: HIV-1 replication inhibitors with improved metabolic stability.

Doohyun Lee, Sung-Jun Han, Wonyoung So, 2012, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.

J. Cechetto, Inhee Choi, Eunjung Park, 2013, European journal of medicinal chemistry.

Discovery of Phenylaminopyridine Derivatives as Novel HIV-1 Non-nucleoside Reverse Transcriptase Inhibitors.

Doohyun Lee, Sung-Jun Han, Wonyoung So, 2012, ACS medicinal chemistry letters.

Discovery and characterization of a novel 7-aminopyrazolo[1,5-a]pyrimidine analog as a potent hepatitis C virus inhibitor.

J. Cechetto, Hee-Young Kim, Junwon Kim, 2012, Bioorganic & medicinal chemistry letters.

Antileishmanial High-Throughput Drug Screening Reveals Drug Candidates with New Scaffolds

Auguste Genovesio, Jiyeon Jang, Jair L. Siqueira-Neto, 2010, PLoS neglected tropical diseases.

Pharmacological perturbation of thiamine metabolism sensitizes Pseudomonas aeruginosa to multiple antibacterial agents.

U. Sauer, J. Cechetto, Soojin Jang, 2022, Cell chemical biology.

Immunogold localization of mitochondrial aspartate aminotransferase in mitochondria and on the cell surface in normal rat tissues.

J. Cechetto, R. Gupta, P. Berk, 2002, Histology and histopathology.

Encapsulation of Anti-Tuberculosis Drugs within Mesoporous Silica and Intracellular Antibacterial Activities

J. Cechetto, David Barros, A. Garcia‐Bennett, 2014, Nanomaterials.

High throughput screening identifies novel inhibitors of Escherichia coli dihydrofolate reductase that are competitive with dihydrofolate.

Eric D. Brown, E. Brown, J. Cechetto, 2003, Bioorganic & medicinal chemistry letters.

High-Throughput Screening Identifies Inhibitors of the SARS Coronavirus Main Proteinase

Eric D. Brown, Nadine H. Elowe, Jan E. Blanchard, 2004, Chemistry & Biology.

Identification of two HIV inhibitors that also inhibit human RNaseH2

J. Cechetto, Junwon Kim, Sung-jun Han, 2013, Molecules and cells.

Serendipitous discovery of 2-((phenylsulfonyl)methyl)-thieno[3,2-d]pyrimidine derivatives as novel HIV-1 replication inhibitors.

J. Cechetto, Sung-jun Han, Inhee Choi, 2014, Bioorganic & medicinal chemistry letters.

Identification of a Novel Sulfonamide Non-Nucleoside Reverse Transcriptase Inhibitor by a Phenotypic HIV-1 Full Replication Assay

Sung-Jun Han, Peter Sommer, Ho Jeong Kwon, 2013, PloS one.

Synthesis and biological evaluation of triazolothienopyrimidine derivatives as novel HIV-1 replication inhibitors.

J. Cechetto, Sung-jun Han, Inhee Choi, 2013, Bioorganic & medicinal chemistry letters.

High content screening for compounds that induce early stages of human embryonic stem cell differentiation.

J. Cechetto, J. Jee, T. Dorval, 2012, Combinatorial chemistry & high throughput screening.

Confocal-Based Method for Quantification of Diffusion Kinetics in Microwell Plates and Its Application for Identifying a Rapid Mixing Method for High-Content/Throughput Screening

H. Kwon, J. Cechetto, T. Christophe, 2010, Journal of biomolecular screening.