P. Grootenhuis

P. Grootenhuis, P. V. Haastert, M. Blaauw, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Expression of a bioactive, single-chain choriogonadotropin in Dictyostelium discoideum.

P. Grootenhuis, P. V. Haastert, M. Blaauw, 1998, European journal of biochemistry.

Macrocyclic receptor molecules with a pendant carboxylic acid group for the complexation of urea

D. Reinhoudt, P. Grootenhuis, R. Bartsch, 1988 .

Computational study of the structural, energetic, and acid-base properties of calix[4]arenes

P. Kollman, D. Reinhoudt, P. Grootenhuis, 1990 .

Computer simulation studies of spherands, crowns and porphyrins: application of computer graphics, distance geometry, molecular mechanics and molecular dynamics approaches

P. Kollman, P. Grootenhuis, M. A. López, 1989 .

Study of the recognition of the heparin-like pentasaccharides by antithrombin III

P. Grootenhuis, C. V. Boeckel, A. Rood, 1993 .

Dissociation of heparin-dependent thrombin and factor Xa inhibitory activities of antithrombin-III by mutations in the reactive site.

P. Grootenhuis, R. Dijkema, H. Theunissen, 1993, The Journal of biological chemistry.

A CHARMm Based Force Field for Carbohydrates Using the CHEAT Approach: Carbohydrate Hydroxyl Groups Represented by Extended Atoms

P. Grootenhuis, C. Haasnoot, Peter D. J. Grootenhuis, 1993 .

Novel acylguanidine containing thrombin inhibitors with reduced basicity at the P1 moiety.

P. Grootenhuis, R. Engh, H. Lucas, 1998, Bioorganic & medicinal chemistry letters.

Peptide-derived transition state analogue inhibitors of thrombin; synthesis, activity and selectivity.

P. Grootenhuis, P D Grootenhuis, M Jetten, 1995, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a backbone-modified phytoalexin elicitor

P. Grootenhuis, J. H. Boom, G. A. Marel, 1997 .

Complexes of macrocyclic polyethers and neutral guest molecules: a systematic approach to the complexation of water molecules by 2,6-pyridinium crown ethers

J. Uiterwijk, D. Reinhoudt, E. Sudhölter, 1986 .

Unique overlap in the prerequisites for thrombin inhibition and oral bioavailability resulting in potent oral antithrombotics.

P. Grootenhuis, M. Smit, C. V. van Boeckel, 2002, Journal of medicinal chemistry.

Arylamidrazones as novel corticotropin releasing factor receptor antagonists.

P. Grootenhuis, A. Termin, M. Ramirez-Weinhouse, 2002, Journal of medicinal chemistry.

Synthetic molecular receptors for urea. Macrocyclic ligands with intraannular acidic groups and the complexes with urea

D. Reinhoudt, P. Grootenhuis, J. V. Eerden, 1988 .

Macrocyclic receptor molecules for urea: the use of electrophiles in the (co-)complexation of neutral molecules

D. Reinhoudt, P. Grootenhuis, J. V. Eerden, 1986 .

Pathways for conformational interconversion of calix[4]arenes

M. Karplus, D. Reinhoudt, Stefan Fischer, 1995 .

Crown ether mediated transport of guanidinium thiocyanate through a bulk liquid membrane and the correlation with the complex stability constants

J. Uiterwijk, D. Reinhoudt, E. Sudhölter, 1986 .

pKa Determination of water-soluble calix[4]arenes

D. Reinhoudt, P. Grootenhuis, S. Shinkai, 1991 .

Basicity and structure of 2,6-pyrido-crown ethers; the effect of ringsize, solvent interactions, and hydrogen bonding

J. Uiterwijk, D. Reinhoudt, P. Grootenhuis, 1984 .

Cycloaddition Reactions of Substituted Allenes with Triplet Excited Aromatic Thiones: Product Formation and Reaction Mechanism

P. Grootenhuis, J. Kamphuis, H. Bos, 1985 .

Stability constants for some divalent metal ion/crown ether complexes in methanol determined by polarography and conductometry

D. Reinhoudt, P. Grootenhuis, M. Bos, 1987 .

Complexation of crown ethers with neutral molecules. 2. Comparison of free macrocycles and their complexes with malononitrile in solution

D. Reinhoudt, P. Grootenhuis, J. V. Eerden, 1986 .

Complexation of neutral molecules by preorganized macrocyclic hosts

D. Reinhoudt, P. Grootenhuis, P. Dijkstra, 1987 .

Effect of preorganization of macrocyclic hosts on the complexation of neutral molecules

D. Reinhoudt, P. Grootenhuis, P. Dijkstra, 1986 .

Thermodynamic stabilities of complexes of synthetic macrocyclic valinomycin mimics with alkali, barium, and guanidinium cations

D. Reinhoudt, P. Grootenhuis, P. V. D. Wal, 1987 .

3D Database searching on the basis of ligand shape using the sperm prototype method

V. J. V. Geerestein, P. Grootenhuis, Peter D. J. Grootenhuis, 1990 .

Conformational analysis of the trimannose Manα(1 → 2)[Manα(1 → 6)]Manβ using the CHEAT95 force field; evaluation of the additivity principle

P. Grootenhuis, R. Schrijvers, C. Haasnoot, 1997 .

Expression of biologically active fusion genes encoding the common α subunit and either the CGβ or FSHβ subunits: role of a linker sequence

P. Grootenhuis, M. Kudo, I. Boime, 1996, Molecular and Cellular Endocrinology.

The intact and cleaved human antithrombin III complex as a model for serpin–proteinase interactions

W. Hol, P. Grootenhuis, H. Schreuder, 1994, Nature Structural Biology.

Carbohydrates and drug discovery--the role of computer simulation.

P. Grootenhuis, C. V. van Boeckel, P D Grootenhuis, 1994, Trends in biotechnology.

Structure-based design and protein engineering of intersubunit disulfide bonds in gonadotropins

P. Grootenhuis, Judith C. Heikoop, Paul van den Boogaart, 1997, Nature Biotechnology.

Evaluation of subunit truncation and the nature of the spacer for single chain human gonadotropins.

P. Grootenhuis, J. Heikoop, P. van den Boogaart, 1997, European journal of biochemistry.

Correction of the F508del-CFTR protein processing defect in vitro by the investigational drug VX-809

P. Negulescu, P. Grootenhuis, J. Wine, 2011, Proceedings of the National Academy of Sciences.

Rescue of DeltaF508-CFTR trafficking and gating in human cystic fibrosis airway primary cultures by small molecules.

James Rader, P. Negulescu, T. Knapp, 2006, American journal of physiology. Lung cellular and molecular physiology.

The second Kunitz domain of human tissue factor pathway inhibitor: cloning, structure determination and interaction with factor Xa.

R. Huber, P. Grootenhuis, W. Bode, 1997, Journal of molecular biology.

Towards minimized gonadotropins with full bioactivity.

P. Grootenhuis, J. Heikoop, B. Huisman-de Winkel, 1999, European journal of biochemistry.

Pharmacological Rescue of Mutant CFTR Function for the Treatment of Cystic Fibrosis

P. Grootenhuis, Sabine Hadida, F. V. Goor, 2008 .

Discovery of N-(2,4-di-tert-butyl-5-hydroxyphenyl)-4-oxo-1,4-dihydroquinoline-3-carboxamide (VX-770, ivacaftor), a potent and orally bioavailable CFTR potentiator.

Jinglan Zhou, P. Negulescu, P. Grootenhuis, 2014, Journal of medicinal chemistry.

X-ray structure of antistasin at 1 . 9 Å resolution and its modelled complex with blood coagulation factor Xa resulting in the formation of fibrin , an insoluble protein

W. Hol, P. Grootenhuis, U. Krengel, 2013 .

Homology model‐building studies of human thrombin: Optimisation of modelling protocol and comparison with X‐ray structure

L. Koymans, P. Grootenhuis, C. Haasnoot, 2010 .

Functionality map analysis of the active site cleft of human thrombin

M Karplus, P D Grootenhuis, M. Karplus, 1996, J. Comput. Aided Mol. Des..

Applications of random sampling to virtual screening of combinatorial libraries.

D C Spellmeyer, P Beroza, E K Bradley, 2000, Journal of molecular graphics & modelling.

Comparison of two implementations of the incremental construction algorithm in flexible docking of thrombin inhibitors

Peter D. J. Grootenhuis, Denis M. Bayada, Vincent J. van Geerestein, 1999, J. Comput. Aided Mol. Des..

Chapter 28. Recent Developments in Molecular Diversity: Computational Approaches to Combinatorial Chemistry

David C. Spellmeyer, D. Spellmeyer, P. Grootenhuis, 1999 .

Coupling structure-based design with combinatorial chemistry: application of active site derived pharmacophores with informative library design.

Christian Lemmen, John E Eksterowicz, Erik Evensen, 2002, Journal of molecular graphics & modelling.

Finding potential DNA-binding compounds by using molecular shape

Diana C. Roe, Irwin D. Kuntz, Peter A. Kollman, 1994, J. Comput. Aided Mol. Des..

Computerized selection of potential DNA binding compounds.

G L Seibel, I D Kuntz, P A Kollman, 1990, Anti-cancer drug design.

A computational ensemble pharmacophore model for identifying substrates of P-glycoprotein.

Erik Evensen, J. Penzotti, P. Grootenhuis, 2002, Journal of medicinal chemistry.

Free energy calculation on base specificity of drug – DNA interactions: Application to daunomycin and acridine intercalation into DNA

P. Kollman, P. Cieplak, P. Grootenhuis, 1990, Biopolymers.

Parametrization and application of CHEAT95, and extended atom force field for hydrated oligosaccharides

P. Grootenhuis, Peter D. J. Grootenhuis, Milou L. C. E. Kouwizjer, 1995 .

CFTR Modulators for the Treatment of Cystic Fibrosis

P. Grootenhuis, Sabine Hadida, F. V. Goor, 2010 .

Partially deglycosylated human choriogonadotropin, stabilized by intersubunit disulfide bonds, shows full bioactivity.

P. Grootenhuis, U. Rose, R. de Leeuw, 1998, European journal of biochemistry.

Rescue of the protein folding defect in cystic fibrosis in vitro by the investigational small molecule, VX-809

P. Negulescu, P. Grootenhuis, J. Wine, 2010 .

N-phenylphenylglycines as novel corticotropin releasing factor receptor antagonists.

J. Penzotti, P. Grootenhuis, H. Wong, 2004, Journal of medicinal chemistry.

Chapter Twenty-Four – Case History: Kalydeco® (VX-770, Ivacaftor), a CFTR Potentiator for the Treatment of Patients with Cystic Fibrosis and the G551D-CFTR Mutation

P. Grootenhuis, Sabine Hadida, K. Dinehart, 2014 .

Synthetic receptors for neutral molecules: complexation of H3O+.(H2O)n (n = 0-2) by 2-sulfo-1,3-xylyl crown ethers

D. Reinhoudt, P. Grootenhuis, J. V. Eerden, 1989 .

Evaluation of a novel shape-based computational filter for lead evolution: application to thrombin inhibitors.

John E Eksterowicz, Erin K Bradley, Robert V Stanton, 2002, Journal of medicinal chemistry.

Comparative molecular field analysis and energy interaction studies of thrombin-inhibitor complexes

Peter D. J. Grootenhuis, Roberta Bursi, R. Bursi, 1999, J. Comput. Aided Mol. Des..

Molecular Mechanics and Dynamics Studies of Crown Ether-Cation Interactions: Free Energy Calculations on the Cation Selectivity of Dibenzo-18-crown-6 and Dibenzo-30-crown-10.

P. Kollman, P. Grootenhuis, 1989 .