M. Walters

Nisha S. Sipes, F. Bushman, D. L. Taylor, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Uncoupling Catalytic and Binding Functions in the cAMP-Dependent Protein Kinase A

S. Taylor, M. Walters, Jonggul Kim, 2016 .

Anthrax toxin lethal factor domain 3 is highly mobile and responsive to ligand binding.

Elizabeth A. Amin, M. Walters, B. Finzel, 2014, Acta crystallographica. Section D, Biological crystallography.

Human Adenine Nucleotide Translocase (ANT) Modulators Identified by High-Throughput Screening of Transgenic Yeast

M. Walters, T. Shiratsuchi, N. Terada, 2016, Journal of biomolecular screening.

Diastereoselective [4+3] Cycloadditions of Enantiopure Nitrogen‐Stabilized Oxyallyl Cations

M. Walters, P. Thornton, D. MaGee, 2006 .

Characterization of caspase‐2 inhibitors based on specific sites of caspase‐2‐mediated proteolysis

K. Ashe, M. Walters, B. Finzel, 2022, Archiv der Pharmazie.

Synthesis of novel analogs of cabergoline: improving cardiovascular safety by removing 5-HT2B receptor agonism.

M. Walters, Suck-Won Kim, P. Dosa, 2013, ACS medicinal chemistry letters.

Targeting caspase-2 interactions with tau in Alzheimer's disease and related dementias.

K. Ashe, M. Walters, Steffen Pockes, 2022, Translational research : the journal of laboratory and clinical medicine.

New telechelic polymers and sequential copolymers by polyfunctional initiator-transfer agents (INIFERS)

M. Walters, J. Kennedy, Raquel Santos, 1984 .

Chapter 5.4 Five-membered ring systems: With more than one N atom

J. R. Vargas, M. Walters, 1997 .

Threonine Cavities Are Targetable Motifs That Control Alpha-Synuclein Fibril Growth.

A. Pandey, M. Walters, J. Sachs, 2022, ACS chemical neuroscience.

Caspase-2 Inhibitor Blocks Tau Truncation and Restores Excitatory Neurotransmission in Neurons Modeling FTDP-17 Tauopathy.

K. Ashe, M. Walters, D. Liao, 2022, ACS chemical neuroscience.

Chapter 1 Recent advances in the synthesis of heterocycles via ring-closing metathesis

M. Walters, 2003 .

A Practical 2,3-Pyridyne Precursor

M. Walters, P. Carter, Satyajit Banerjee, 1992 .

Diversity-Oriented Library Synthesis from Steviol and Isosteviol-Derived Scaffolds.

Oliver E. Hutt, M. Walters, G. Georg, 2020, ACS combinatorial science.

Regiocontrolled metalation of diethyl β-dialkylaminovinylphosphonates: A new synthesis of substituted β-ketophosphonates

M. Walters, R. K. Boeckman, H. Koyano, 1989 .

AB INITIO INVESTIGATION OF THREE 3-AZA-CLAISEN VARIATIONS

M. Walters, 1994 .

Synthesis of Guaianolide Analogues with a Tunable α-Methylene-γ-lactam Electrophile and Correlating Bioactivity with Thiol Reactivity.

M. Walters, D. Harki, François Grillet, 2020, Journal of medicinal chemistry.

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Jayme L. Dahlin, Michael A. Walters, J. Willem M. Nissink, 2015, Bioorganic & medicinal chemistry letters.

The essential roles of chemistry in high-throughput screening triage.

Jayme L. Dahlin, Michael A Walters, Jayme L Dahlin, 2014, Future medicinal chemistry.

Studies directed toward the total synthesis of tetronolide 2. A stereoselective route to the racemic cyclohexene subunit

M. Walters, R. K. Boeckman, S. G. Nelson, 1991 .

3,3'-Disubstituted 5,5'-Bi(1,2,4-triazine) Derivatives with Potent in Vitro and in Vivo Antimalarial Activity.

Jayme L. Dahlin, R. Price, S. Ralph, 2019, Journal of medicinal chemistry.

The first example of a nitrogen-substituted oxyallyl cation cycloaddition

M. Walters, H. R. Arcand, Dawn J. Lawrie, 1995 .

Recent Advances in the Synthesis of Heterocycles via Ring-Closing Metathesis

M. Walters, 2004 .

An extremely mild 3-aza-Claisen reaction. 1. Rearrangement of simple N-allylamides.

M. Walters, C. Mcdonough, P. Brown, 1991 .

Ab Initio Investigation of the 3-Aza-Cope Reaction

M. Walters, 1996 .

Rearrangements of Substituted 3-Aza-1,2,5-hexatrienes. 3. The Scope and Versatility of an Extremely Mild 3-Aza-Cope Reaction

M. Walters, C. Mcdonough, A. B. Hoem, 1996 .

The anionic 1-Aza-cope rearrangement. Theoretical evidence for the intramolecular reaction of imide anions with alkenes

M. Walters, 1995 .

The promise and peril of chemical probes.

John P. Overington, Jian Jin, Matthieu Schapira, 2015, Nature chemical biology.

Nuisance compounds in cellular assays.

Jayme L. Dahlin, Bruce K. Hua, J. Baell, 2021, Cell chemical biology.

Identification of Novel Non-Hydroxamate Anthrax Toxin Lethal Factor Inhibitors by Topomeric Searching, Docking and Scoring, and in Vitro Screening

Elizabeth A. Amin, Xia Zhang, Barry C. Finzel, 2009, J. Chem. Inf. Model..

A Simple and Efficient Ozone Generator

M. Walters, J. BelBruno, Deborah J. Sponholtz, 1999 .

Polarization and concentration dependence of two-photon forbidden electronic origins: the 1B2u of benzene in solution

M. Walters, D. Friedrich, J. V. Alsten, 1980 .

2,3-Pyridyne Formation by Fluoride-Induced Desilylation-Elimination

M. Walters, J. J. Shay, 1997 .

Templates for exploratory library preparation. Derivatization of a functionalized spirocyclic 3,6-dihydro-2H-pyran formed by ring-closing metathesis reaction.

M. Walters, P. Deshmukh, D. Omecinsky, 2002, Journal of combinatorial chemistry.

2,2‐Dimethyl‐1,3‐propanediol

M. Walters, J. J. Shay, 2001 .

Experiences in Academic and Industry Partnerships – Forging a Path to Translational Drug Discovery

Vadim J. Gurvich, N. Carragher, S. Frye, 2021 .

Histone-modifying enzymes, histone modifications and histone chaperones in nucleosome assembly: Lessons learned from Rtt109 histone acetyltransferases

Jayme L. Dahlin, Zhiguo Zhang, M. Walters, 2015, Critical reviews in biochemistry and molecular biology.

Discovery of Acylsulfonohydrazide-Derived Lysine Acetyltransferase (KAT6A) Inhibitors as Potent Senescence-Inducing Anti-Cancer Agents.

Jayme L. Dahlin, David M. Shackleford, J. Baell, 2020, Journal of medicinal chemistry.

Mitigating risk in academic preclinical drug discovery

James Inglese, Jayme L. Dahlin, Michael A. Walters, 2015, Nature Reviews Drug Discovery.

Uncoupling Catalytic and Binding Functions in the Cyclic AMP-Dependent Protein Kinase A.

Susan S. Taylor, M. Walters, Jonggul Kim, 2016, Structure.

Specific inhibition of p97/VCP ATPase and kinetic analysis demonstrate interaction between D1 and D2 ATPase domains.

Henry J. Lin, M. Walters, M. Arkin, 2014, Journal of molecular biology.

A novel P300 inhibitor reverses DUX4-mediated global histone H3 hyperacetylation, target gene expression, and cell death

M. Kyba, A. Jadhav, M. Walters, 2019, Science Advances.

Transcriptional Inhibitors Identified in a 160,000-Compound Small-Molecule DUX4 Viability Screen

M. Kyba, M. Walters, S. Choi, 2016, Journal of biomolecular screening.

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

H. Zoghbi, H. Orr, M. Walters, 2018, Neurobiology of Disease.

Pneumocystis jirovecii Rtt109, a Novel Drug Target for Pneumocystis Pneumonia in Immunosuppressed Humans

Jayme L. Dahlin, Junhong Han, Zhiguo Zhang, 2014, Antimicrobial Agents and Chemotherapy.

Pneumocystis jirovecii PjRtt109: A Novel Drug Target for Pneumocystis

Jayme L. Dahlin, Junhong Han, Zhiguo Zhang, 2014 .

ALARM NMR for HTS Triage and Chemical Probe Validation

Jayme L. Dahlin, M. Walters, G. Veglia, 2018, Current protocols in chemical biology.

GSTO1-1 plays a pro-inflammatory role in models of inflammation, colitis and obesity

Jayme L. Dahlin, J. Baell, P. Tummala, 2017, Scientific Reports.

Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors.

Jayme L. Dahlin, J. Baell, P. Tummala, 2020, Journal of medicinal chemistry.

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Jayme L. Dahlin, M. Walters, D. Lafontaine, 2020, ACS medicinal chemistry letters.

Synthetic studies of the cyclopropyl iminium ion rearrangement. 3. Application of the cyclopropyl acyliminium ion rearrangement to a concise and highly convergent synthesis of (.+-.)-lycorine

M. Walters, R. K. Boeckman, S. Goldstein, 1988 .

Solution-phase library synthesis of furanoses.

M. Walters, A. M. Boldi, Elaine B Krueger, 2002, Journal of combinatorial chemistry.

Two new methods for 2,3-Pyridyne formation

M. Walters, J. J. Shay, 1995 .

How to Triage PAINS-Full Research.

Jayme L. Dahlin, Michael A Walters, Jayme L Dahlin, 2016, Assay and drug development technologies.

Assay Interference by Chemical Reactivity

Jayme L. Dahlin, Jonathan B. Baell, Michael A. Walters, 2015 .

Structure-Based Design and Biological Evaluation of Novel Caspase2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314

K. Ashe, M. Walters, B. Finzel, 2022, ACS Pharmacology & Translational Science.

Probing the S2' Subsite of the Anthrax Toxin Lethal Factor Using Novel N-Alkylated Hydroxamates.

Elizabeth A. Amin, M. Walters, B. Finzel, 2015, Journal of medicinal chemistry.

The use of vinyl imidazoles as Diels-Alder dienes

M. Walters, Melissa D. Lee, 1994 .

Improved machine learning models for predicting selective compounds

George Karypis, Xia Ning, Michael A. Walters, 2011, BCB '11.

Structure-Based Design and Biological Evaluation of Novel Caspase-2 Inhibitors Based on the Peptide AcVDVAD-CHO and the Caspase-2-Mediated Tau Cleavage Sequence YKPVD314.

K. Ashe, M. Walters, B. Finzel, 2022, ACS pharmacology & translational science.

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

M. Kyba, M. Walters, S. Choi, 2014, Skeletal Muscle.

High-throughput screening identifies inhibitors of DUX4-induced myoblast toxicity

Michael Kyba, Michael A Walters, Si Ho Choi, 2014, Skeletal Muscle.

Assay interference and off-target liabilities of reported histone acetyltransferase inhibitors

Jayme L. Dahlin, J. Baell, M. Walters, 2017, Nature Communications.

Discovery of benzoylsulfonohydrazides as potent inhibitors of the histone acetyltransferase KAT6A.

Jayme L. Dahlin, J. Baell, M. Walters, 2019, Journal of medicinal chemistry.

Intramolecular 2-azaallyl anion cycloadditions. Application to the synthesis of fused bicyclic pyrrolidines

M. Walters, W. H. Pearson, K. Oswell, 1986 .

Assessing Synthetic Accessibility of Chemical Compounds Using Machine Learning Methods

George Karypis, Michael A. Walters, Yevgeniy Podolyan, 2010, J. Chem. Inf. Model..

Specific Inhibition of p 97 / VCP ATPase and Kinetic Analysis Demonstrate Interaction between D 1 and D 2 ATPase domains

Henry J. Lin, M. Walters, M. Arkin, 2014 .

An electrophilic fragment screening for the development of small molecules targeting caspase-2.

K. Ashe, M. Hall, Hongmao Sun, 2023, European journal of medicinal chemistry.

Improving natural product research translation: From source to clinical trial.

Daniel Lakens, Dan Xi, Guido F Pauli, 2019, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

The Communication of Hit Quality Using Natural History Visualizations (NHVs)

M. Walters, Kathryn M. Nelson, 2021, SLAS discovery : advancing life sciences R & D.

Post-HTS case report and structural alert: Promiscuous 4-aroyl-1,5-disubstituted-3-hydroxy-2H-pyrrol-2-one actives verified by ALARM NMR.

Jayme L. Dahlin, Zhiguo Zhang, M. Walters, 2015, Bioorganic & Medicinal Chemistry Letters.

In situ Preparation and Subsequent Use of Isomerically Pure E- and Z-Crotylamines in a 3-Aza-Claisen Rearrangement

M. Walters, A. B. Hoem, 1994 .

Remodelin Is a Cryptic Assay Interference Chemotype That Does Not Inhibit NAT10-Dependent Cytidine Acetylation.

Jayme L. Dahlin, M. Walters, D. Lafontaine, 2020, ACS medicinal chemistry letters.

Reduction of protein kinase A-mediated phosphorylation of ATXN1-S776 in Purkinje cells delays onset of Ataxia in a SCA1 mouse model

H. Zoghbi, H. Orr, M. Walters, 2018, Neurobiology of Disease.

The promise and peril of chemical probes (vol 11, pg 536, 2015)

John P. Overington, Jayme L. Dahlin, Christopher M. Austin, 2015 .