D. Julius

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Identification of a cold receptor reveals a general role for TRP channels in thermosensation

D. McKemy, W. M. Neuhausser, D. Julius, 2002, Nature.

The Cloned Capsaicin Receptor Integrates Multiple Pain-Producing Stimuli

A. Basbaum, D. Julius, M. Tominaga, 1998, Neuron.

Lessons from peppers and peppermint: the molecular logic of thermosensation

D. McKemy, D. Julius, S. Jordt, 2003, Current Opinion in Neurobiology.

The capsaicin receptor: a heat-activated ion channel in the pain pathway

D. Julius, M. Tominaga, M. Caterina, 1997, Nature.

A capsaicin-receptor homologue with a high threshold for noxious heat

D. Julius, M. Tominaga, M. Caterina, 1999, Nature.

Sense and specificity: a molecular identity for nociceptors

D. Julius, M. Caterina, 1999, Current Opinion in Neurobiology.

Molecular mechanisms of nociception

A. Basbaum, D. Julius, 2001, Nature.

Structure of the TRPA1 ion channel suggests regulatory mechanisms

D. Julius, Yifan Cheng, J. Armache, 2015, Nature.

Structure of the TRPV1 ion channel determined by electron cryo-microscopy

D. Julius, Yifan Cheng, M. Liao, 2013, Nature.

Signaling by sensory receptors.

J. Nathans, D. Julius, 2012, Cold Spring Harbor perspectives in biology.

Vanilloid receptors on sensory nerves mediate the vasodilator action of anandamide

D. Julius, D. Andersson, V. Marzo, 1999, Nature.

New structural motif for ligand-gated ion channels defined by an ionotropic ATP receptor

D. Julius, A. Brake, M. Wagenbach, 1994, Nature.

Substitution of three amino acids switches receptor specificity of Gqα to that of Giα

B. Conklin, H. Bourne, D. Julius, 1993, Nature.

Substitution of three amino acids switches receptor specificity of Gq alpha to that of Gi alpha.

B. Conklin, H. Bourne, D. Julius, 1993, Nature.

TRPV1 structures in distinct conformations reveal mechanisms of activation

D. Julius, Yifan Cheng, M. Liao, 2013, Nature.

TRPV1 structures in nanodiscs reveal mechanisms of ligand and lipid action

D. Julius, Yifan Cheng, Yuan Gao, 2016, Nature.

TRPA1 Mediates the Inflammatory Actions of Environmental Irritants and Proalgesic Agents

David Julius, Allan I. Basbaum, Diana M. Bautista, 2006, Cell.

TRPA1 mediates formalin-induced pain

Michael Zhao, David Julius, Diana M. Bautista, 2007, Proceedings of the National Academy of Sciences.

The menthol receptor TRPM8 is the principal detector of environmental cold

David Julius, Allan I. Basbaum, Diana M. Bautista, 2007, Nature.

Eating disorder and epilepsy in mice lacking 5-HT2C serotonin receptors

David Julius, Laurence H. Tecott, Daniel H. Lowenstein, 1995, Nature.

The 5-HT3 Subtype of Serotonin Receptor Contributes to Nociceptive Processing via a Novel Subset of Myelinated and Unmyelinated Nociceptors

A. Basbaum, D. Julius, A. Malmberg, 2002, The Journal of Neuroscience.

Molecular Basis of Infrared Detection by Snakes

Jonathan S. Weissman, David Julius, J. Weissman, 2010, Nature.

Yeast α factor is processed from a larger precursor polypeptide: The essential role of a membrane-bound dipeptidyl aminopeptidase

J. Thorner, G. Sprague,, D. Julius, 1983, Cell.

Impaired nociception and pain sensation in mice lacking the capsaicin receptor.

A I Basbaum, A. Basbaum, D. Julius, 2000, Science.

Transient Receptor Potential channels (TRP) in GtoPdb v.2022.1

D. Clapham, C. Grimm, D. McKemy, 2022, IUPHAR/BPS Guide to Pharmacology CITE.

International Union of Pharmacology. XLIX. Nomenclature and Structure-Function Relationships of Transient Receptor Potential Channels

Craig Montell, David E. Clapham, David Julius, 2005, Pharmacological Reviews.

International Union of Pharmacology. XLIII. Compendium of Voltage-Gated Ion Channels: Transient Receptor Potential Channels

Craig Montell, David E. Clapham, David Julius, 2003, Pharmacological Reviews.

A unified nomenclature for the superfamily of TRP cation channels.

Craig Montell, Michael J Caterina, Stefan Heller, 2002, Molecular cell.

Pharmacology of the Nav1.1 domain IV voltage sensor reveals coupling between inactivation gating processes

D. Julius, Jeremiah D. Osteen, K. Sampson, 2017, Proceedings of the National Academy of Sciences.

The vanilloid receptor: a molecular gateway to the pain pathway.

D. Julius, M. Caterina, M J Caterina, 2001, Annual review of neuroscience.

Neuroanatomical evidence for segregation of nerve fibers conveying light touch and pain sensation in Eimer's organ of the mole.

P. Marasco, D. Julius, K. Catania, 2006, Proceedings of the National Academy of Sciences of the United States of America.

A Bivalent Tarantula Toxin Activates the Capsaicin Receptor, TRPV1, by Targeting the Outer Pore Domain

D. Julius, Christopher J. Bohlen, J. Siemens, 2010, Cell.

Mechanisms governing irritant-evoked activation and calcium modulation of TRPA1

D. Julius, Yifan Cheng, C. E. Paulsen, 2019, bioRxiv.

Expression cloning of an ATP receptor from mouse neuroblastoma cells.

D. Julius, A. Brake, A. Shiau, 1993, Proceedings of the National Academy of Sciences of the United States of America.

ATP receptors in sickness, pain and death.

D. Julius, M. Schumacher, A. Brake, 1996, Chemistry & biology.

TRP channel activation by reversible covalent modification

D. Julius, H. Chuang, D. Bautista, 2006, Proceedings of the National Academy of Sciences.

Neuronal Expression of the 5HT3 Serotonin Receptor Gene Requires Nuclear Factor 1 Complexes

D. Julius, H. Ingraham, F. K. Bedford, 1998, The Journal of Neuroscience.

Structural insight into TRPV5 channel function and modulation

D. Julius, Yifan Cheng, J. van der Wijst, 2018, Proceedings of the National Academy of Sciences.

Electrosensory Transduction: Comparisons Across Structure, Afferent Response Properties, and Cellular Physiology

D. B. Leitch, D. Julius, D. Leitch, 2019, Electroreception: Fundamental Insights from Comparative Approaches.

TRPV1 drugs alter core body temperature via central projections of primary afferent sensory neurons

A. Basbaum, D. Julius, J. Braz, 2022, bioRxiv.

A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence

J. Thorner, D. Julius, A. Brake, 1983, Molecular and cellular biology.

A heteromeric Texas coral snake toxin targets acid-sensing ion channels to produce pain

A. Burlingame, A. Basbaum, K. Medzihradszky, 2011, Nature.

Uropathic Observations in Mice Expressing a Constitutively Active Point Mutation in the 5-HT3A Receptor Subunit

H. Lester, D. Cockayne, A. Ford, 2004, The Journal of Neuroscience.

Molecular biology of serotonin receptors.

D. Julius, 1991, Annual review of neuroscience.

Molecular basis of ancestral vertebrate electroreception

D. B. Leitch, D. Julius, Nicholas W. Bellono, 2017, Nature.

Serotonin receptor 1c gene assigned to X chromosome in human (band q24) and mouse (bands D-F4).

L. Tecott, U. Francke, D. Julius, 1992, Human molecular genetics.

Expression of a Serotonin-Gated Ion Channel in Embryonic Neural and Nonneural Tissues

L. Tecott, D. Julius, S. Shtrom, 1995, Molecular and Cellular Neuroscience.

Toward better pain control.

A. Basbaum, D. Julius, 2006, Scientific American.

Another opiate for the masses?

D. Julius, 1997, Nature.

Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway.

R. Schekman, J. Thorner, D. Julius, 1984, Cell.

Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function

Benjamin R. Myers, A. Hudspeth, A. Schier, 2008, The Journal of Neuroscience.

The P2Y12 receptor regulates microglial activation by extracellular nucleotides

W. Gan, Guang Yang, D. Julius, 2006, Nature Neuroscience.

Home for an orphan endorphin

D. Julius, 1995, Nature.

Identification of the platelet ADP receptor targeted by antithrombotic drugs

David Julius, Paquita Nurden, P. Nurden, 2001, Nature.

The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors.

T. Jessell, R. Axel, D. Julius, 1990, Proceedings of the National Academy of Sciences of the United States of America.

Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-α-factor

J. Thorner, D. Julius, A. Brake, 1984, Cell.

Spider toxins activate the capsaicin receptor to produce inflammatory pain

Ellen A. Lumpkin, David Julius, Allan I. Basbaum, 2006, Nature.

Cellular and Molecular Mechanisms of Pain

David Julius, Allan I. Basbaum, Diana M. Bautista, 2009, Cell.

Selective Blockade of the Capsaicin Receptor TRPV1 Attenuates Bone Cancer Pain

N. Carruthers, P. Mantyh, M. Kuskowski, 2005, The Journal of Neuroscience.

Primary structure and functional expression of the 5HT3 receptor, a serotonin-gated ion channel.

R. Myers, D. Julius, A. V. Maricq, 1991, Science.

Ganglion-specific splicing of TRPV1 underlies infrared sensation in vampire bats

Nicholas T. Ingolia, J. Weissman, D. Julius, 2011, Nature.

Mustard oils and cannabinoids excite sensory nerve fibres through the TRP channel ANKTM1

D. McKemy, D. Julius, S. Jordt, 2004, Nature.

Bradykinin and nerve growth factor release the capsaicin receptor from PtdIns(4,5)P2-mediated inhibition

A. Basbaum, D. Julius, S. Jordt, 2001, Nature.

TRP channels and pain.

D. Julius, 2013, Annual review of cell and developmental biology.

Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels

Yaron M Sigal, R. Nicoll, Aaron D. Milstein, 2008, Nature Neuroscience.

Pungent products from garlic activate the sensory ion channel TRPA1.

Olov Sterner, David Julius, D. Julius, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Cytoplasmic ankyrin repeats of transient receptor potential A1 (TRPA1) dictate sensitivity to thermal and chemical stimuli

D. Julius, Elena O. Gracheva, J. Cordero-Morales, 2011, Proceedings of the National Academy of Sciences.

Membrane mimetic systems in CryoEM: keeping membrane proteins in their native environment.

D. Julius, Yifan Cheng, H. Autzen, 2019, Current opinion in structural biology.

4-Hydroxynonenal, an endogenous aldehyde, causes pain and neurogenic inflammation through activation of the irritant receptor TRPA1

A. Basbaum, D. Julius, G. Cottrell, 2007, Proceedings of the National Academy of Sciences.

Trpv1 Reporter Mice Reveal Highly Restricted Brain Distribution and Functional Expression in Arteriolar Smooth Muscle Cells

D. J. Cavanaugh, Yaron M Sigal, R. Nicoll, 2011, The Journal of Neuroscience.

Molecular characterization of a functional cDNA encoding the serotonin 1c receptor.

T. Jessell, R. Axel, D. Julius, 1988, Science.

Molecular Basis for Species-Specific Sensitivity to “Hot” Chili Peppers

David Julius, D. Julius, S. Jordt, 2002, Cell.

The Super-Cooling Agent Icilin Reveals a Mechanism of Coincidence Detection by a Temperature-Sensitive TRP Channel

D. Julius, H. Chuang, W. Neuhausser, 2004, Neuron.

Selective spider toxins reveal a role for Nav1.1 channel in mechanical pain

A. Basbaum, D. Julius, C. Stucky, 2016, Nature.

A Nobel for Smell

L. C. Katz, D. Julius, 2004, Cell.

Enterochromaffin Cells Are Gut Chemosensors that Couple to Sensory Neural Pathways

David Julius, D. Julius, S. Brierley, 2017, Cell.

Signaling Mechanisms Controlling Cell Fate and Embryonic Patterning Subject Collection Signal Transduction The Hippo Pathway

J. Nathans, P. Ingham, D. Sabatini, 2012 .

Glycosylation and processing of prepro-α-factor through the yeast secretory pathway

R. Schekman, J. Thorner, D. Julius, 1984, Cell.

Restriction of Transient Receptor Potential Vanilloid-1 to the Peptidergic Subset of Primary Afferent Neurons Follows Its Developmental Downregulation in Nonpeptidergic Neurons

D. J. Cavanaugh, A. Basbaum, D. Julius, 2011, The Journal of Neuroscience.

Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation.

T. Jessell, R. Axel, D. Julius, 1989, Science.

Effects of 5-HT1C-receptor expression on cell proliferation control in hamster fibroblasts: serotonin fails to induce a transformed phenotype.

D. Julius, J. Pouysségur, K. Seuwen, 1992, Experimental cell research.

ATP transduces signals from ASGM1, a glycolipid that functions as a bacterial receptor

David Julius, D. McKemy, D. Julius, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Acid potentiation of the capsaicin receptor determined by a key extracellular site.

D. Julius, M. Tominaga, S. Jordt, 2000, Proceedings of the National Academy of Sciences of the United States of America.

A new wave of serotonin receptors

L. Tecott, D. Julius, 1993, Current Opinion in Neurobiology.

Single particle electron cryo-microscopy of a mammalian ion channel.

Yifan Cheng, David Julius, Maofu Liao, 2014, Current opinion in structural biology.

The serotonin receptor subtype 2 locusHTR2 is on human chromosome 13 near genes for esterase D and retinoblastoma-1 and on mouse chromosome 14

L. Cavalli-Sforza, A. Bowcock, L. Farrer, 1990, Somatic cell and molecular genetics.

Gut Enterochromaffin Cells are Critical Drivers of Visceral Pain and Anxiety

Ryan D Morrie, A. Venkataraman, D. Julius, 2022, bioRxiv.

Nervous system distribution of the serotonin 5-HT3 receptor mRNA.

L. Tecott, D. Julius, A. V. Maricq, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Irritant-evoked activation and calcium modulation of the TRPA1 receptor

D. Julius, Yifan Cheng, C. E. Paulsen, 2020, Nature.

Irritant-evoked activation and calcium modulation of the TRPA1 receptor

D. Julius, Yifan Cheng, C. E. Paulsen, 2020, Nature.

A Cell-Penetrating Scorpion Toxin Enables Mode-Specific Modulation of TRPA1 and Pain

K. Medzihradszky, D. Julius, G. King, 2019, Cell.

Tissue-specific contributions of Tmem79 to atopic dermatitis and mast cell-mediated histaminergic itch

D. Julius, M. Rosenblum, K. Gronert, 2018, Proceedings of the National Academy of Sciences.

Evolution of Thermal Response Properties in a Cold-Activated TRP Channel

Benjamin R. Myers, Yaron M Sigal, D. Julius, 2009, PloS one.

TRPV1 Channels Are Intrinsically Heat Sensitive and Negatively Regulated by Phosphoinositide Lipids

D. Julius, Beiying Liu, F. Qin, 2013, Neuron.

Structural insights into TRPM8 inhibition and desensitization

D. Julius, Yifan Cheng, M. Diver, 2019, Science.

Structure of the human TRPM4 ion channel in a lipid nanodisc

Daniel Asarnow, Yifan Cheng, Alexander G Myasnikov, 2018, Science.

Sensory TRP Channels in Three Dimensions.

D. Julius, Yifan Cheng, M. Diver, 2022, Annual review of biochemistry.

A Yeast Genetic Screen Reveals a Critical Role for the Pore Helix Domain in TRP Channel Gating

Benjamin R. Myers, D. Julius, Christopher J. Bohlen, 2008, Neuron.

Differential contribution of TRPV1 to thermal responses and tissue injury-induced sensitization of dorsal horn neurons in laminae I and V in the mouse

A. Basbaum, D. Julius, W. Eckert, 2006, Pain.

Structural snapshots of TRPV1 reveal mechanism of polymodal functionality

D. Julius, Yifan Cheng, Kaihua Zhang, 2021, Cell.

A Modular PIP2 Binding Site as a Determinant of Capsaicin Receptor Sensitivity

D. Julius, E. D. Prescott, 2003, Science.

5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.

T. Jessell, R. Axel, D. Julius, 1989, Proceedings of the National Academy of Sciences of the United States of America.

Capsaicin receptor in the pain pathway.

D. Julius, M. Tominaga, David Julius, 2000, Japanese journal of pharmacology.

Trpv 1 reporter mice reveal highly restricted brain distribution and functional expression in arteriolar smooth muscle cells

D. J. Cavanaugh, Yaron M Sigal, R. Nicoll, 2015 .

TRP'S Sensational Pathways: Unlocking Mysteries of Pain & Temperature

D. Julius, Jonathan Flaksman, 2011 .

TRP Channel Structural Biology: New Roles for an Old Fold

D. Julius, B. Myers, 2007, Neuron.

Cellular and molecular properties of primary afferent neurons

D. Julius, E. Mccleskey, E. McCleskey, 2006 .

Transient Receptor Potential channels (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

D. Clapham, D. McKemy, D. Julius, 2019, IUPHAR/BPS Guide to Pharmacology CITE.

Coiled Coils Direct Assembly of a Cold-Activated TRP Channel

D. Julius, D. Minor, Pamela R. Tsuruda, 2006, Neuron.

From peppers to peppermints: natural products as probes of the pain pathway.

D. Julius, 2005, Harvey lectures.

X-Ray Structure of Acid-Sensing Ion Channel 1–Snake Toxin Complex Reveals Open State of a Na+-Selective Channel

E. Gouaux, D. Julius, A. Goehring, 2014, Cell.

Structure of acid-sensing ion channel in complex with snake toxin

E. Gouaux, D. Julius, A. Goehring, 2014 .

Receptor-targeting mechanisms of pain-causing toxins: How ow?

D. Julius, Christopher J. Bohlen, 2012, Toxicon : official journal of the International Society on Toxinology.

Gut enterochromaffin cells drive visceral pain and anxiety

Ryan D Morrie, D. Julius, S. Brierley, 2023, Nature.

Co‐localization of endomorphin‐2 and substance P in primary afferent nociceptors and effects of injury: a light and electron microscopic study in the rat

A. Basbaum, D. Julius, K. Skinner, 2004, The European journal of neuroscience.

Transient Receptor Potential channels (TRP) in GtoPdb v.2023.1

D. Clapham, C. Grimm, D. McKemy, 2023, IUPHAR/BPS Guide to Pharmacology CITE.

Molecular tuning of electroreception in sharks and skates

D. Julius, Nicholas W. Bellono, D. Leitch, 2018, Nature.

Radial stretch reveals distinct populations of mechanosensitive mammalian somatosensory neurons

David Julius, Ellen A Lumpkin, D. Julius, 2008, Proceedings of the National Academy of Sciences.

A step-by-step protocol for capturing conformational snapshots of ligand gated ion channels by single-particle cryo-EM

D. Julius, Yifan Cheng, Kaihua Zhang, 2022, STAR protocols.

Lys49 myotoxin from the Brazilian lancehead pit viper elicits pain through regulated ATP release

A. Basbaum, K. Medzihradszky, D. Julius, 2017, Proceedings of the National Academy of Sciences.

Multiple Unbiased Prospective Screens Identify TRP Channels and Their Conserved Gating Elements

Benjamin R. Myers, C. Kung, D. Julius, 2008, The Journal of general physiology.

カプサイシン受容体：熱・プロトンで活性化されるイオンチャネル

D. Julius, M. Caterina, Tobias A. Rosen, 1999 .

Mechanical, thermal and formalin-induced nociception is differentially altered in 5-HT1A−/−, 5-HT1B−/−, 5-HT2A−/−, 5-HT3A−/− and 5-HTT−/− knock-out male mice

D. Julius, M. Hamon, J. Gingrich, 2007, PAIN.

Inactivation of a serotonin-gated ion channel by a polypeptide toxin from marine snails.

D. Julius, J. Rivier, B. Olivera, 1998, Science.

ContributionofthePutativeInner-PoreRegiontotheGating oftheTransientReceptorPotentialVanilloidSubtype1 Channel(TRPV1)

D. Julius, 2007 .

Immunoreactive TRPV‐2 (VRL‐1), a capsaicin receptor homolog, in the spinal cord of the rat

A. Basbaum, D. Julius, K. Skinner, 2004, The Journal of comparative neurology.

Structure of the TRPA1 ion channel suggests regulatory mechanisms

D. Julius, Yifan Cheng, J. Armache, 2015, Nature.

Allosteric regulation of TRPV1 by the inflammatory lipid LPA

D. Julius, Yifan Cheng, William R. Arnold, 2023, bioRxiv.

A Neuropeptide Courier for δ-Opioid Receptors?

A. Basbaum, D. Julius, 2005, Cell.

Fire in the hole: pore dilation of the capsaicin receptor TRPV1

D. Julius, D. Bautista, 2008, Nature Neuroscience.

Motion-corrected Fourier ptychography

Bian, Ang, Eng, 2016 .

Signaling by sensory receptors.

J. Nathans, D. Julius, 2012, Cold Spring Harbor perspectives in biology.

Zebrafish TRPA1 Channels Are Required for Chemosensation But Not for Thermosensation or Mechanosensory Hair Cell Function

Benjamin R. Myers, A. Hudspeth, A. Schier, 2008, The Journal of Neuroscience.

Neurobiology 5-HT 1 c receptor is a prominent serotonin receptor subtype in the central nervous system ( 5-HTlc receptor / serotonin / in situ hybridizadon / central nervous system / neurotransmission )

T. Jessell, R. Axel, D. Julius, 2022 .

Receptor-targeting mechanisms of pain-causing toxins: How ow?

D. Julius, Christopher J. Bohlen, 2012, Toxicon.

Anandamide - the other side of the coin.

D. Julius, V. Marzo, P. Zygmunt, 2000, Trends in pharmacological sciences.