K. Tsukuda

发表

The relationship between epidermal growth factor receptor mutations and clinicopathologic features in non-small cell lung cancers.

S. Toyooka, A. Gazdar, Masaki Tokumo, 2005, Clinical cancer research : an official journal of the American Association for Cancer Research.

Interaction of cytokeratin 19 head domain and HER2 in the cytoplasm leads to activation of HER2-Erk pathway

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2016, Scientific Reports.

Relation of epidermal growth factor receptor, phosphorylated-Akt, and hypoxia-inducible factor-1alpha in non-small cell lung cancers.

Nobuyoshi Shimizu, Hiroshi Date, Kazunori Tsukuda, 2004, Cancer letters.

Estimation of age-related DNA degradation from formalin-fixed and paraffin-embedded tissue according to the extraction methods.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2017, Experimental and therapeutic medicine.

DNA methylation of multiple genes and clinicopathological relationship of non-small cell lung cancers.

S. Toyooka, M. Aoe, M. Yano, 2004, Oncology reports.

The proliferative effects of asbestos-exposed peripheral blood mononuclear cells on mesothelial cells

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2016, Oncology letters.

The aberrant promoter methylation of BMP3b and BMP6 in malignant pleural mesotheliomas.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2008, Oncology reports.

Non-BAC Component but not Epidermal Growth Factor Receptor Gene Mutation is Associated with Poor Outcomes in Small Adenocarcinoma of the Lung

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2008, Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer.

DNA methylation in small lung adenocarcinoma with bronchioloalveolar carcinoma components.

Hiromasa Yamamoto, S. Toyooka, K. Kiura, 2009, Lung cancer.

Distant Bystander Effect of REIC/DKK3 Gene Therapy Through Immune System Stimulation in Thoracic Malignancies.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2017, Anticancer research.

Application of amplicon-based targeted sequencing with the molecular barcoding system to detect uncommon minor EGFR mutations in patients with treatment-naïve lung adenocarcinoma

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2019, BMC Cancer.

Establishment and molecular characterization of cell lines from Japanese patients with malignant pleural mesothelioma.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2016, Oncology letters.

Detection of codon 61 point mutations of the K-ras gene in lung and colorectal cancers by enriched PCR.

J. Soh, S. Toyooka, M. Yano, 2003, Oncology Report.

DNA methylation status of REIC/Dkk-3 gene in human malignancies

N. Taira, J. Soh, S. Toyooka, 2012, Journal of Cancer Research and Clinical Oncology.

Detection of EGFR Gene Mutation in Lung Cancer by Mutant-Enriched Polymerase Chain Reaction Assay

S. Toyooka, Masaki Tokumo, K. Kiura, 2006, Clinical Cancer Research.

DNA copy number gains in malignant pleural mesothelioma.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2015, Oncology letters.

Transforming activity of the RL‐akt gene, a c‐akt gene activated by long terminal repeat insertion in murine leukemia RL♂1 cells

K. Tsukuda, M. Tanino, E. Nakayama, 1999 .

A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival

J. Soh, S. Toyooka, K. Tsukuda, 2002, American Journal of Gastroenterology.

A case of pancreatic adenocarcinoma with novel K-ras mutation and long term survival.

J. Soh, S. Toyooka, K. Tsukuda, 2002 .

Elacridar, a third-generation ABCB1 inhibitor, overcomes resistance to docetaxel in non-small cell lung cancer.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2017, Oncology letters.

Yes1 signaling mediates the resistance to Trastuzumab/Lap atinib in breast cancer

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2017, PloS one.

Aberrant promoter methylation of human DAB2 interactive protein (hDAB2IP) gene in lung cancers

S. Toyooka, A. Gazdar, M. Aoe, 2005, International journal of cancer.

Abdominal wall and thigh abscess resulting from the penetration of ascending colon cancer.

T. Nogami, K. Tsukuda, Y. Ishihara, 2005, Acta medica Okayama.

Aberrant promoter methylation of insulin‐like growth factor binding protein‐3 gene in human cancers

S. Toyooka, H. Doihara, K. Tomii, 2007, International journal of cancer.

Effects of adenoviral-mediated hepatocyte growth factor on liver regeneration after massive hepatectomy in rats.

H. Doihara, K. Tsukuda, H. Date, 2007, Acta medica Okayama.

Therapeutic potential of targeting S100A11 in malignant pleural mesothelioma

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2018, Oncogenesis.

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.

Hiromasa Yamamoto, J. Soh, S. Toyooka, 2013, Lung cancer.

Proteasome inhibitors can alter the signaling pathways and attenuate the P‐glycoprotein‐mediated multidrug resistance

T. Fujita, H. Doihara, K. Tsukuda, 2005, International journal of cancer.

Proteasome inhibitor bortezomib increases PTEN expression and enhances trastuzumab-induced growth inhibition in trastuzumab-resistant cells

T. Fujita, H. Doihara, K. Tsukuda, 2006, Anti-cancer drugs.

A case of ileal perforation of malignant lymphoma occurring after lung transplantation

S. Toyooka, T. Nogami, K. Tsukuda, 2011 .

The relationship between NY-ESO-1 mRNA expression and clinicopathological features in non-small cell lung cancer.

S. Toyooka, M. Aoe, K. Tsukuda, 2004, Oncology reports.

Human collagen XV is a prominent histopathological component of sinusoidal capillarization in hepatocellular carcinogenesis

S. Miyoshi, I. Naito, A. Ohtsuka, 2016, International Journal of Clinical Oncology.

Breast cancer with cartilaginous and/or osseous metaplasia diagnosed by lymph nodal metastasis: a case report.

K. Tsukuda, K. Aokage, H. Masuda, 2009, Acta medica Okayama.

The Outcome of Gastrointestinal Stromal Tumors (GISTs) After a Surgical Resection in Our Institute

K. Tsukuda, E. Ikeda, Shoji Takagi, 2007, Surgery Today.

A Case of Sigmoid Colon Cancer that was Unexpectedly Found during Emergency Operation of a Ruptured Abdominal Aortic Aneurysm

K. Tsukuda, E. Ikeda, S. Furutani, 2006 .

Thymidine Phosphorylase and Dihydropyrimidine Dehydrogenase Expression Levels in Tumor and Normal Tissue Specimens of T3 Human Colorectal Carcinoma

H. Doihara, K. Tsukuda, N. Shimizu, 2006, Surgery Today.

Ileal perforation induced by acute radiation injury under gefitinib treatment

S. Toyooka, S. Miyoshi, K. Tsukuda, 2011, International Journal of Clinical Oncology.

Duodenal carcinoma from a duodenal diverticulum mimicking pancreatic carcinoma.

Masaki Tokumo, K. Tsukuda, M. Furukawa, 2012, Acta medica Okayama.

Angiogenesis Inhibitor TNP-470 Can Suppress Hepatocellular Carcinoma Growth Without Retarding Liver Regeneration After Partial Hepatectomy

K. Tsukuda, N. Shimizu, Ryuji Hirai, 2003, Surgery Today.

A CASE OF TRAUMATIC SPLENIC INJURY EFFECTIVELY TREATED USING AN INTRA-AORTIC BALLOON OCCLUDER

S. Miyoshi, K. Tsukuda, Hiroaki Asano, 2010 .

Impact of endoscopic and histological evaluations of two different types of mesh plug for a groin hernia model

S. Miyoshi, K. Tsukuda, Tatsuro Hayashi, 2011, Surgery today (Print).

Hsp 90 inhibitor NVP-AUY 922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors

J. Soh, S. Toyooka, S. Miyoshi, 2015 .

A CASE OF ILEAL OBSTRUCTION CAUSED BY ENDOMETRIOSIS OF THE APPENDIX

K. Tsukuda, E. Ikeda, Keitaro Watanabe, 2008 .

Acquired resistance to EGFR inhibitors is associated with a manifestation of stem cell-like properties in cancer cells.

W. Lam, J. Soh, S. Toyooka, 2013, Cancer research.

Multiple gastrointestinal stromal tumors in neurofibromatosis type 1 treated with laparoscopic surgery.

K. Tsukuda, E. Ikeda, Keitaro Watanabe, 2007, Acta medica Okayama.

Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

J. Soh, S. Toyooka, S. Miyoshi, 2011, Clinical Cancer Research.

Targeting the miR-200c/LIN28B axis in acquired EGFR-TKI resistance non-small cell lung cancer cells harboring EMT features

J. Soh, S. Toyooka, S. Miyoshi, 2017, Scientific Reports.

Optimal method for quantitative detection of plasma EGFR T790M mutation using droplet digital PCR system.

J. Soh, S. Toyooka, S. Miyoshi, 2017, Oncology reports.

Aberrant methylation of p21 gene in lung cancer and malignant pleural mesothelioma.

Hiroaki Asano, Kazunori Tsukuda, J. Soh, 2011, Acta medica Okayama.

The allelic distribution of a single nucleotide polymorphism in the PDCD5 gene locus of Japanese non-small cell lung cancer patients.

J. Soh, S. Toyooka, K. Matsuo, 2008, Molecular medicine reports.

Downregulation of microRNA-34 induces cell proliferation and invasion of human mesothelial cells.

J. Soh, S. Toyooka, S. Miyoshi, 2013, Oncology reports.

TAE226, a Bis-Anilino Pyrimidine Compound, Inhibits the EGFR-Mutant Kinase Including T790M Mutant to Show Anti-Tumor Effect on EGFR-Mutant Non-Small Cell Lung Cancer Cells

J. Soh, S. Toyooka, S. Miyoshi, 2015, PLoS ONE.

nm23‐H1 reduces in vitro cell migration and the liver metastatic potential of colon cancer cells by regulating myosin light chain phosphorylation

Nobuyoshi Shimizu, Eiji Suzuki, Masakazu Murakami, 2004, International journal of cancer.

Dose effect of smoking on aberrant methylation in non‐small cell lung cancers

J. Minna, S. Toyooka, A. Gazdar, 2004, International journal of cancer.

Aberrant Promoter Methylation in Human DAB2 Interactive Protein (hDAB2IP) Gene in Breast Cancer

S. Toyooka, H. Doihara, A. Gazdar, 2004, Clinical Cancer Research.

Double mutation and gene copy number of EGFR in gefitinib refractory non-small-cell lung cancer.

S. Toyooka, Masaki Tokumo, K. Kiura, 2006, Lung cancer.

A CASE OF TRANSMESOCOLIC HERNIA OF ASCENDING COLON

K. Tsukuda, E. Ikeda, Shoji Takagi, 2006 .

Tumor‐specific exon creation of the HELLS/SMARCA6 gene in non‐small cell lung cancer

S. Toyooka, H. Shigematsu, M. Yano, 2004, International journal of cancer.

Strong anti-tumor effect of NVP-AUY922, a novel Hsp90 inhibitor, on non-small cell lung cancer.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Lung cancer.

Antitumor activity of pan‐HER inhibitors in HER2‐positive gastric cancer

J. Soh, S. Toyooka, K. Tsukuda, 2018, Cancer science.

Congenital Heart Disease with Hypereosinophilic Syndrome

K. Tsukuda, N. Yoshimura, Y. Ootaki, 2003, Pediatric Cardiology.

Hsp90 inhibitor NVP-AUY922 enhances the radiation sensitivity of lung cancer cell lines with acquired resistance to EGFR-tyrosine kinase inhibitors.

J. Soh, S. Toyooka, S. Miyoshi, 2015, Oncology reports.

Smoke exposure, histologic type and geography‐related differences in the methylation profiles of non‐small cell lung cancer

J. Minna, S. Toyooka, J. Roth, 2003, International journal of cancer.

Acquisition of cancer stem cell-like properties in non-small cell lung cancer with acquired resistance to afatinib

J. Soh, S. Toyooka, S. Miyoshi, 2015, Cancer science.

Silenced expression of NFKBIA in lung adenocarcinoma patients with a never-smoking history.

J. Soh, S. Toyooka, S. Miyoshi, 2013, Acta medica Okayama.

Tumor-suppressive effect of LRIG1, a negative regulator of ErbB, in non-small cell lung cancer harboring mutant EGFR

J. Soh, S. Toyooka, S. Miyoshi, 2018, Carcinogenesis.

Tumor-suppressive effect of LRIG 1 in lung cancer

J. Soh, S. Toyooka, S. Miyoshi, 2022 .

Impact of GLUT1 and Ki-67 expression on early‑stage lung adenocarcinoma diagnosed according to a new international multidisciplinary classification.

J. Soh, S. Toyooka, S. Miyoshi, 2013, Oncology reports.

Usefulness of cumulative smoking dose for identifying the EGFR mutation and patients with non‐small‐cell lung cancer for gefitinib treatment

S. Toyooka, S. Miyoshi, K. Matsuo, 2009, Cancer science.

Genetic alterations in lung adenocarcinoma with a micropapillary component.

J. Soh, S. Toyooka, S. Miyoshi, 2016, Molecular and clinical oncology.

Antitumor effect of afatinib , as a HER 2-targeted therapy , in lung cancers harboring HER 2 oncogene alterations

J. Soh, S. Toyooka, S. Miyoshi, 2015 .

Anti-Cancer Effects of REIC/Dkk-3-encoding Adenoviral Vector for the Treatment of Non-small Cell Lung Cancer

J. Soh, S. Toyooka, S. Miyoshi, 2014, PloS one.

Antitumor effect of afatinib, as a human epidermal growth factor receptor 2‐targeted therapy, in lung cancers harboring HER2 oncogene alterations

J. Soh, S. Toyooka, S. Miyoshi, 2015, Cancer Science.

Presence of the minor EGFR T790M mutation is associated with drug-sensitive EGFR mutations in lung adenocarcinoma patients.

J. Soh, S. Toyooka, S. Miyoshi, 2014, Oncology reports.

SYT-SSX fusion genes in synovial sarcoma of the thorax.

S. Toyooka, M. Aoe, K. Ichimura, 2004, Lung cancer.

Knockdown of the epidermal growth factor receptor gene to investigate its therapeutic potential for the treatment of non-small-cell lung cancers.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Clinical lung cancer.

Antitumor effect of gefitinib ('Iressa') on esophageal squamous cell carcinoma cell lines in vitro and in vivo.

N. Taira, F. Hara, S. Toyooka, 2005, Cancer letters.

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Lung cancer.

An E2F-responsive replication-selective adenovirus targeted to the defective cell cycle in cancer cells: potent antitumoral efficacy but no toxicity to normal cell.

K. Tsukuda, K. Molnar-Kimber, R. Wiewrodt, 2002, Cancer research.

Genetic alterations in the retinoblastoma protein-related p107 gene in human hematologic malignancies.

K. Tsukuda, K. Ichimura, K. Shimizu, 1998, Biochemical and biophysical research communications.

Aberrant methylation of p57KIP2 gene in lung and breast cancers and malignant mesotheliomas.

S. Toyooka, H. Doihara, M. Toyota, 2004, Oncology reports.

Predictive factors for the effectiveness of neoadjuvant chemotherapy and prognosis in triple-negative breast cancer patients

H. Doihara, S. Miyoshi, K. Tsukuda, 2011, Cancer Chemotherapy and Pharmacology.

Prognostic impact of cancer stem cell-related markers in non-small cell lung cancer patients treated with induction chemoradiotherapy.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Lung cancer.

Gefitinib decreases the synthesis of matrix metalloproteinase and the adhesion to extracellular matrix proteins of colon cancer cells.

K. Tsukuda, N. Shimizu, Keitaro Watanabe, 2006, Anticancer research.

Quantitative Analysis of Cyclin Dl Messenger RNA Expression in Head and Neck Squamous Cell Carcinomas

K. Tsukuda, N. Monden, K. Shimizu, 1997, Japanese journal of cancer research : Gann.

Novel Germline Mutation in the Transmembrane Domain of HER2 in Familial Lung Adenocarcinomas

J. Soh, S. Toyooka, S. Miyoshi, 2013, Journal of the National Cancer Institute.

A novel activating mutation of the K-ras gene in human primary colon adenocarcinoma.

K. Tsukuda, M. Tanino, K. Shimizu, 2000, Biochemical and biophysical research communications.

Totally laparoscopic colectomy with intracorporeal anastomosis for colonic liposarcoma: A case report

K. Tsukuda, Sumiharu Yamamoto, Atsushi Okita, 2022, Asian journal of endoscopic surgery.

Impact of aberrant methylation of microRNA-9 family members on non-small cell lung cancers.

J. Soh, S. Toyooka, S. Miyoshi, 2013, Molecular and clinical oncology.

Biliary reconstruction with right hepatic lobectomy due to delayed management of laparoscopic bile duct injuries: a case report.

K. Tsukuda, N. Shimizu, T. Ota, 2004, Acta medica Okayama.

HD-PTP: A novel protein tyrosine phosphatase gene on human chromosome 3p21.3.

S. Toyooka, K. Tsukuda, M. Ouchida, 2000, Biochemical and biophysical research communications.

A CASE OF AGGRESSIVE ANGIOMYXOMA GROWING INTO THE PELVIC CAVITY

K. Tsukuda, N. Shimizu, D. Takabatake, 2003 .

Therapeutic strategies for afatinib‐resistant lung cancer harboring HER2 alterations

J. Soh, S. Toyooka, S. Miyoshi, 2018, Cancer science.

The relationship between aberrant methylation and survival in non-small-cell lung cancers

S. Toyooka, A. Gazdar, M. Aoe, 2004, British Journal of Cancer.

A case of colonoscope incarceration within a left inguinal hernia

K. Tsukuda, Takafumi Kubo, 2012 .

A Case of Ischemic Proctocolitis Induced by Anaphylactic Shock Following Bee Stings

K. Tsukuda, K. Ichimura, M. Yano, 2013 .

MicroRNA miR-34b/c enhances cellular radiosensitivity of malignant pleural mesothelioma cells.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Anticancer research.

Preclinical evaluation of microRNA-34b/c delivery for malignant pleural mesothelioma.

J. Soh, S. Toyooka, S. Miyoshi, 2014, Acta medica Okayama.

Mutation analysis of the BRAF codon 599 in malignant pleural mesothelioma by enriched PCR-RFLP.

S. Toyooka, H. Pass, M. Yano, 2004, Oncology Report.

The effect of epidermal growth factor receptor antisense morpholino oligomer on non-small cell lung cancer cell line.

S. Toyooka, M. Aoe, K. Tsukuda, 2003, Oncology reports.

Abstract 724: Anti-tumor effect of Dasatinib in HER2 positive breast cancer with Trastuzumab resistance

J. Soh, S. Toyooka, S. Miyoshi, 2015 .

Abscess formation of the round ligament of the liver: report of a case.

K. Tsukuda, E. Ikeda, A. Tada, 2008, Acta medica Okayama.

Promoter methylation downregulates CDX2 expression in colorectal carcinomas.

S. Toyooka, K. Tomii, M. Yano, 2005, Oncology reports.

PTEN activity could be a predictive marker of trastuzumab efficacy in the treatment of ErbB2-overexpressing breast cancer

T. Fujita, H. Doihara, K. Tsukuda, 2006, British Journal of Cancer.

The degree of microRNA-34b/c methylation in serum-circulating DNA is associated with malignant pleural mesothelioma.

J. Soh, S. Toyooka, S. Miyoshi, 2013, Lung Cancer.

Epigenetic Silencing of MicroRNA-34b/c Plays an Important Role in the Pathogenesis of Malignant Pleural Mesothelioma

J. Soh, S. Toyooka, S. Miyoshi, 2011, Clinical Cancer Research.

Frequent methylation and oncogenic role of microRNA-34b/c in small-cell lung cancer.

J. Soh, S. Toyooka, S. Miyoshi, 2012, Lung cancer.