J. Martín

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Transcriptional analysis of the F0F1 ATPase operon of Corynebacterium glutamicum ATCC 13032 reveals strong induction by alkaline pH.

Mónica Barriuso-Iglesias, C. Barreiro, F. Flechoso, 2006, Microbiology.

Two overlapping antiparallel genes encoding the iron regulator DmdR1 and the Adm proteins control sidephore and antibiotic biosynthesis in Streptomyces coelicolor A3(2)

C. Barreiro, J. Martín, S. Tunca, 2009, The FEBS journal.

Proteome Analysis of the Penicillin Producer Penicillium chrysogenum

Carlos García-Estrada, Mohammad-Saeid Jami, C. García-Estrada, 2010, Molecular & Cellular Proteomics.

Resolution of four large chromosomes in penicillin-producing filamentous fungi: the penicillin gene cluster is located on chromosome II (9.6 Mb) in Penicillium notatum and chromosome 1 (10.4 Mb) in Penicillium chrysogenum

J. Martín, B. Díez, F. Fierro, 1993, Molecular and General Genetics MGG.

Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites, Volume 2

C. García-Estrada, J. Martín, S. Zeilinger, 2015, Fungal Biology.

Fungal Transformation: From Protoplasts to Targeted Recombination Systems

J. Martín, 2015 .

Agrobacterium tumefaciens-mediated transformation of the antitumor clavaric acid-producing basidiomycete Hypholoma sublateritium

Eduardo J. Gudiña, J. Martín, J. Martín, 2004, Current Genetics.

Microarray studies reveal a 'differential response' to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum.

J. Kalinowski, A. Hüser, C. Barreiro, 2009, Microbiology.

Connecting primary and secondary metabolism: AreB, an IclR‐like protein, binds the AREccaR sequence of S. clavuligerus and modulates leucine biosynthesis and cephamycin C and clavulanic acid production

J. Martín, P. Liras, I. Santamarta, 2007, Molecular microbiology.

Transcriptional Analysis of the groES-groEL1, groEL2, and dnaK genes in Corynebacterium glutamicum: Characterization of Heat Shock-Induced Promoters

M. Pátek, C. Barreiro, J. Martín, 2013, Journal of bacteriology.

Regulation and compartmentalization of β‐lactam biosynthesis

C. García-Estrada, J. Martín, R. Ullán, 2010, Microbial biotechnology.

Evolutionary formation of gene clusters by reorganization: the meleagrin/roquefortine paradigm in different fungi

J. Martín, P. Liras, 2015, Applied Microbiology and Biotechnology.

Key role of LaeA and velvet complex proteins on expression of β-lactam and PR-toxin genes in Penicillium chrysogenum: cross-talk regulation of secondary metabolite pathways

J. Martín, 2017, Journal of Industrial Microbiology & Biotechnology.

Target genes of the Streptomyces tsukubaensis FkbN regulator include most of the tacrolimus biosynthesis genes, a phosphopantetheinyl transferase and other PKS genes

J. Martín, María Ordóñez-Robles, A. Rodríguez-García, 2016, Applied Microbiology and Biotechnology.

Transcriptomic Analysis of Streptomyces coelicolor Differentiation in Solid Sporulating Cultures: First Compartmentalized and Second Multinucleated Mycelia Have Different and Distinctive Transcriptomes

J. Martín, Á. Manteca, P. Yagüe, 2013, PloS one.

CcaR Is an Autoregulatory Protein That Binds to the ccaR and cefD-cmcI Promoters of the Cephamycin C-Clavulanic Acid Cluster in Streptomyces clavuligerus

J. Martín, P. Liras, I. Santamarta, 2002, Journal of bacteriology.

The two-component phoR-phoP system of Streptomyces natalensis: Inactivation or deletion of phoP reduces the negative phosphate regulation of pimaricin biosynthesis.

J. Martín, S. Tunca, M. V. Mendes, 2007, Metabolic engineering.

ArgR of Streptomyces coelicolor Is a Versatile Regulator

J. Martín, P. Liras, I. Santamarta, 2012, PloS one.

The dynamic architecture of the metabolic switch in Streptomyces coelicolor

Kay Nieselt, Rainer Breitling, Eriko Takano, 2010, BMC Genomics.

Genome‐wide transcriptomic and proteomic analysis of the primary response to phosphate limitation in Streptomyces coelicolor M145 and in a ΔphoP mutant

C. Barreiro, J. Martín, Fernando Santos-Beneit, 2007, Proteomics.

Cross‐talk between two global regulators in Streptomyces: PhoP and AfsR interact in the control of afsS, pstS and phoRP transcription

J. Martín, Fernando Santos-Beneit, Antonio Rodríguez-García, 2009, Molecular microbiology.

Is PhoR–PhoP partner fidelity strict? PhoR is required for the activation of the pho regulon in Streptomyces coelicolor

J. Martín, F. Santos-Beneit, L. Fernández-Martínez, 2012, Molecular Genetics and Genomics.

Biosynthesis and Molecular Genetics of Fungal Secondary Metabolites

C. García-Estrada, J. Martín, S. Zeilinger, 2014, Fungal Biology.

Transport systems, intracellular traffic of intermediates and secretion of β-lactam antibiotics in fungi

J. Martín, 2020, Fungal Biology and Biotechnology.

University of Groningen The unprocessed preprotein form IAT ( C 103 S ) of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing

C. García-Estrada, J. Martín, M. Veenhuis, 2017 .

The unprocessed preprotein form IATC103S of the isopenicillin N acyltransferase is transported inside peroxisomes and regulates its self-processing.

C. García-Estrada, J. Martín, M. Veenhuis, 2008, Fungal genetics and biology : FG & B.

Molecular characterization of a fungal gene paralogue of the penicillin penDE gene of Penicillium chrysogenum

C. García-Estrada, J. Martín, R. Bovenberg, 2009, BMC Microbiology.

Omics Approaches Applied to Penicillium chrysogenum and Penicillin Production: Revealing the Secrets of Improved Productivity

C. García-Estrada, C. Barreiro, J. Martín, 2020, Genes.

Role of peroxisomes in the biosynthesis and secretion of β-lactams and other secondary metabolites

C. García-Estrada, J. Martín, R. Ullán, 2012, Journal of Industrial Microbiology & Biotechnology.

Molecular Mechanisms of Phosphate Sensing, Transport and Signalling in Streptomyces and Related Actinobacteria

J. Martín, P. Liras, 2021, International journal of molecular sciences.

A rhodanese‐like protein is highly overrepresented in the mutant S. clavuligerus oppA2::aph: effect on holomycin and other secondary metabolites production

J. Martín, P. Liras, I. Santamarta, 2011, Microbial biotechnology.

β-Lactam Antibiotics

J. Martín, P. Liras, 2009 .

Mutants of Streptomyces clavuligerus with Disruptions in Different Genes for Clavulanic Acid Biosynthesis Produce Large Amounts of Holomycin: Possible Cross-Regulation of Two Unrelated Secondary Metabolic Pathways

J. Martín, P. Liras, Á. de la Fuente, 2002, Journal of bacteriology.

Genome-wide analysis of differentially expressed genes from Penicillium chrysogenum grown with a repressing or a non-repressing carbon source

J. Martín, F. Fierro, S. Gutiérrez, 2006, Current Genetics.

Purification and characterization of the isopenicillin N epimerase from Nocardia lactamdurans

J. Martín, J. Castro, P. Liras, 1990 .

Metabolic Engineering of the Lysine Pathway for β-Lactam Overproduction in Penicillium Chrysogenum

J. Martín, S. Gutiérrez, J. Casqueiro, 2001 .

Catabolism of phenylacetic acid in Penicillium rubens. Proteome-wide analysis in response to the benzylpenicillin side chain precursor.

C. García-Estrada, C. Barreiro, J. Martín, 2018, Journal of proteomics.

The inducers 1,3-diaminopropane and spermidine cause the reprogramming of metabolism in Penicillium chrysogenum, leading to multiple vesicles and penicillin overproduction.

C. García-Estrada, C. Barreiro, J. Martín, 2013, Journal of proteomics.

Penicillium chrysogenum var. halophenolicum, a new halotolerant strain with potential in the remediation of aromatic compounds in high salt environments.

C. García-Estrada, J. Martín, B. Mendes, 2012, Microbiological research.

Applied Microbial and Cell Physiology

J. Martín, R. Ullán, M. Fernández-Aguado, 2022 .

Penicillin production by mutants resistant to phenylacetic acid

J. Martín, J. Barrios-González, E. Montenegro, 1993 .

Elicitation of Penicillin Biosynthesis by Alginate in Penicillium chrysogenum, Exerted on pcbAB, pcbC, and penDE Genes at the Transcriptional Level

J. Martín, S. Gutiérrez, J. Casqueiro, 2001 .

Modulation of Aspergillus awamori Thaumatin Secretion by Modification of bipA Gene Expression

J. Martín, M. Lombraña, F. Moralejo, 2004, Applied and Environmental Microbiology.

Silencing of the Aspergillopepsin B (pepB) Gene of Aspergillus awamori by Antisense RNA Expression or Protease Removal by Gene Disruption Results in a Large Increase in Thaumatin Production

J. Martín, F. Fierro, S. Gutiérrez, 2002, Applied and Environmental Microbiology.

Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor

Kay Nieselt, Nigel J. Burroughs, Trond E. Ellingsen, 2012, Applied Microbiology and Biotechnology.

Regulation of Geldanamycin Biosynthesis by Cluster-Situated Transcription Factors and the Master Regulator PhoP

J. Martín, P. Liras, A. Ramos, 2019, Antibiotics.

Self-control of the PHO regulon: the PhoP-dependent protein PhoU controls negatively expression of genes of PHO regulon in Streptomyces coelicolor

J. Martín, A. Rodríguez-García, A. Sola-Landa, 2017, The Journal of Antibiotics.

Analysis of the Pho regulon in Streptomyces tsukubaensis.

J. Martín, María Ordóñez-Robles, A. Rodríguez-García, 2017, Microbiological research.

The master regulator PhoP coordinates phosphate and nitrogen metabolism, respiration, cell differentiation and antibiotic biosynthesis: comparison in Streptomyces coelicolor and Streptomyces avermitilis

J. Martín, P. Liras, A. Rodríguez-García, 2017, The Journal of Antibiotics.

Cross‐Talk of Global Regulators in Streptomyces

J. Martín, P. Liras, A. Sola-Landa, 2016 .

Transcriptional response to vancomycin in a highly vancomycin-resistant Streptomyces coelicolor mutant.

J. Martín, Á. Manteca, P. Yagüe, 2014, Future microbiology.

Vancomycin resistance in Streptomyces coelicolor is phosphate-dependent but is not mediated by the PhoP regulator.

J. Martín, F. Santos-Beneit, 2013, Journal of global antimicrobial resistance.

Dissociation of cephamycin and clavulanic acid biosynthesis in Streptomyces clavuligerus

J. Martín, J. Martín, P. Liras, 1984, Applied Microbiology and Biotechnology.

Complex Transcriptional Control of the Antibiotic Regulator afsS in Streptomyces: PhoP and AfsR Are Overlapping, Competitive Activators

J. Martín, A. Rodríguez-García, F. Santos-Beneit, 2011, Journal of bacteriology.

The RNA Polymerase Omega Factor RpoZ Is Regulated by PhoP and Has an Important Role in Antibiotic Biosynthesis and Morphological Differentiation in Streptomyces coelicolor

Mónica Barriuso-Iglesias, J. Martín, Miriam Martínez-Castro, 2011, Applied and Environmental Microbiology.

The isopenicillin N acyltransferases of Aspergillus nidulans and Penicillium chrysogenum differ in their ability to maintain the 40-kDa alphabeta heterodimer in an undissociated form.

J. Martín, F. J. Fernández, S. Gutiérrez, 2003, European journal of biochemistry.

Isolation of Penicillium nalgiovense strains impaired in penicillin production by disruption of the pcbAB gene and application as starters on cured meat products.

J. Martín, F. Fierro, F. Laich, 2003, Mycological research.

Production of Penicillin by Fungi Growing on Food Products: Identification of a Complete Penicillin Gene Cluster in Penicillium griseofulvum and a Truncated Cluster in Penicillium verrucosum

J. Martín, F. Fierro, F. Laich, 2002, Applied and Environmental Microbiology.

Genes for β-lactam antibiotic biosynthesis

J. Martín, S. Gutiérrez, 2004, Antonie van Leeuwenhoek.

Characterization of the ask–asd operon in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331

J. Martín, J. Martín, E. Recio, 2004, Applied Microbiology and Biotechnology.

Transcriptomic Analysis of Liquid Non-Sporulating Streptomyces coelicolor Cultures Demonstrates the Existence of a Complex Differentiation Comparable to That Occurring in Solid Sporulating Cultures

J. Martín, Á. Manteca, P. Yagüe, 2014, PloS one.

Cross‐talk of global nutritional regulators in the control of primary and secondary metabolism in Streptomyces

C. Prieto, J. Martín, A. Rodríguez-García, 2011, Microbial biotechnology.

Engineering of regulatory cascades and networks controlling antibiotic biosynthesis in Streptomyces.

J. Martín, P. Liras, 2010, Current opinion in microbiology.

Applied Microbial and Cell Physiology

C. Barreiro, J. Martín, Miriam Martínez-Castro, 2022 .

The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.

C. García-Estrada, J. Martín, I. Vaca, 2009, The Biochemical journal.

Biosynthetic gene clusters for relevant secondary metabolites produced by Penicillium roqueforti in blue cheeses

C. García-Estrada, J. Martín, 2016, Applied Microbiology and Biotechnology.

Two Oligopeptide-Permease-Encoding Genes in the Clavulanic Acid Cluster of Streptomyces clavuligerus Are Essential for Production of the β-Lactamase Inhibitor

J. Martín, P. Liras, I. Santamarta, 2004, Journal of bacteriology.

The PenV vacuolar membrane protein that controls penicillin biosynthesis. is a putative member of a subfamily of stress-gated transient receptor calcium channels

J. Martín, P. Liras, 2021, Current Research in Biotechnology.

Gene organization and plasticity of the β-lactam genes in different filamentous fungi

J. Martín, F. Fierro, S. Gutiérrez, 2004, Antonie van Leeuwenhoek.

Targeted Inactivation of the mecB Gene, Encoding Cystathionine-γ-Lyase, Shows that the Reverse Transsulfuration Pathway Is Required for High-Level Cephalosporin Biosynthesis inAcremonium chrysogenum C10 but Not for Methionine Induction of the Cephalosporin Genes

J. Martín, S. Gutiérrez, Gang Liu, 2001, Journal of bacteriology.

Co-transformation with autonomous replicating and integrative plasmids in Penicillium chrysogenum is highly efficient and leads in some cases to rescue of the intact integrative plasmid.

J. Martín, S. Gutiérrez, J. Casqueiro, 2003, Fungal genetics and biology : FG & B.

Biological control of mites by xerophile Eurotium species isolated from the surface of dry cured ham and dry beef cecina

J. Martín, S. Campoy, José F Ortiz-Lemus, 2020, Journal of applied microbiology.

Roquefortine C and Related Prenylated Indole Alkaloids

C. García-Estrada, J. Martín, P. Liras, 2014 .

Screening of plasmids in non-pathogenic corynebacteria

L. M. Mateos, J. Martín, H. Sandoval, 1985 .

The pga1 gene of Penicillium chrysogenum NRRL 1951 encodes a heterotrimeric G protein alpha subunit that controls growth and development.

J. Martín, F. Fierro, R. García-Rico, 2007, Research in microbiology.

Glycopeptides and bacterial cell walls

C. Barreiro, J. Martín, F. Santos-Beneit, 2014 .

Analysis of the codon usage of the cephamycin C producer Nocardia lactamdurans

M. Malumbres, J. Martín, J. Coque, 1993 .

Cloning and expression in Escherichia coli of the homoserine kinase (thrB) gene from Brevibacterium lactofermentum

L. M. Mateos, J. Martín, G. Real, 1987, Molecular and General Genetics MGG.

Penicillin-Binding Proteins, β-Lactamases, and β-Lactamase Inhibitors in β-Lactam-Producing Actinobacteria: Self-Resistance Mechanisms

J. Martín, P. Liras, R. Álvarez-Álvarez, 2022, International journal of molecular sciences.

The pcd Gene Encoding Piperideine-6-Carboxylate Dehydrogenase Involved in Biosynthesis of α-Aminoadipic Acid Is Located in the Cephamycin Cluster ofStreptomyces clavuligerus

J. Martín, F. Enguita, P. Liras, 1998, Journal of bacteriology.

Formation of bulges associated with penicillin production in high-producing strains ofPenicillium chrysogenum

A. Dominguez, J. Martín, J. Luengo, 1986, Current Microbiology.

Expression of genes and processing of enzymes for the biosynthesis of penicillins and cephalosporins

J. Martín, F. J. Fernández, F. Fierro, 2004, Antonie van Leeuwenhoek.

Nitrate regulation of α-aminoadipate reductase formation and lysine inhibition of its activity in Penicillium chrysogenum and Acremonium chrysogenum

J. Martín, J. F. Aparicio, M. J. Hijarrubia, 2002, Applied Microbiology and Biotechnology.

Cloning, sequence analysis and transcriptional study of the isopenicillin N synthase of Penicillium chrysogenum AS-P-78

J. Martín, J. Barredo, B. Díez, 1989, Molecular and General Genetics MGG.

1-Lactam Precursor oL-Aminoadipic Acid, Is Located in the Cluster of Cephamycin Biosynthetic Genes in Nocardia lactamdurans

J. Martín, J. Coque, P. Liras, 1991 .

Microbial cholesterol oxidases: bioconversion enzymes or signal proteins?

J. Martín, J. F. Aparicio, 2008, Molecular bioSystems.

Cholesterol oxidases act as signaling proteins for the biosynthesis of the polyene macrolide pimaricin.

J. Martín, Susana M. Guerra, M. V. Mendes, 2007, Chemistry & biology.

Molecular characterization of the PR-toxin gene cluster in Penicillium roqueforti and Penicillium chrysogenum: cross talk of secondary metabolite pathways.

C. García-Estrada, J. Martín, R. Ullán, 2014, Fungal genetics and biology : FG & B.

Control of antibiotic synthesis by phosphate

J. Martín, 1977 .

Evolution of fungal β-lactam biosynthesis gene clusters

C. García-Estrada, J. Martín, F. Fierro, 2011 .

A Novel Epimerization System in Fungal Secondary Metabolism Involved in the Conversion of Isopenicillin N into Penicillin N inAcremonium chrysogenum *

J. Martín, F. J. Fernández, S. Gutiérrez, 2002, The Journal of Biological Chemistry.

A single cluster of coregulated genes encodes the biosynthesis of the mycotoxins roquefortine C and meleagrin in Penicillium chrysogenum.

C. García-Estrada, J. Martín, P. Durek, 2011, Chemistry & biology.

Isolation and physical characterization of plasmid pCCl from Corynebacterium callunae and construction of hybrid derivatives

J. Martín, C. Paniagua, H. Sandoval, 1984, Applied Microbiology and Biotechnology.

Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Applied Microbiology and Biotechnology.

Yeast HXK2 gene reverts glucose regulation mutation of penicillin biosynthesis in P. chrysogenum

J. Martín, F. Fierro, F. Fernández, 2014, Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology].

Complex transcriptional control of the antibiotic regulator

J. Martín, A. Rodríguez-García, F. Santos-Beneit, 2011 .

The enigmatic lack of glucose utilization in Streptomyces clavuligerus is due to inefficient expression of the glucose permease gene.

J. Martín, P. Liras, R. Bovenberg, 2010, Microbiology.

Efficient pyramidal arrangement of an ordered cosmid library: Rapid screening of genes of the tacrolimus-producer Streptomyces sp. ATCC 55098.

C. Barreiro, J. Martín, Miriam Martínez-Castro, 2009, Journal of microbiological methods.

Transcriptional regulation of the desferrioxamine gene cluster of Streptomyces coelicolor is mediated by binding of DmdR1 to an iron box in the promoter of the desA gene

C. Barreiro, J. Martín, S. Tunca, 2007, The FEBS journal.

Expression of the Streptomyces griseus α-amylase gene in Escherichia coli

J. Martín, J. Gil, T. Vigal, 1994 .

A bifunctionalStreptomyces-E. colipromoter-probe vetor

J. Martín, P. Liras, J. Asturias, 1990 .

Molecular Control of Polyene Macrolide Biosynthesis

J. Martín, Susana M. Guerra, J. F. Aparicio, 2010, The Journal of Biological Chemistry.

Enzymology of the polyenes pimaricin and candicidin biosynthesis.

J. Martín, J. F. Aparicio, 2009, Methods in enzymology.

PimM, a PAS domain positive regulator of pimaricin biosynthesis in Streptomyces natalensis.

J. Martín, Susana M. Guerra, M. V. Mendes, 2007, Microbiology.

Penicillin and cephalosporin biosynthesis: Mechanism of carbon catabolite regulation of penicillin production

J. Martín, A. T. Marcos, J. Casqueiro, 2004, Antonie van Leeuwenhoek.

Heterotrimeric Galpha protein Pga1 of Penicillium chrysogenum controls conidiation mainly by a cAMP-independent mechanism.

J. Martín, F. Fierro, R. García-Rico, 2008, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Comparative Molecular Mechanisms of Biosynthesis of Naringenin and Related Chalcones in Actinobacteria and Plants: Relevance for the Obtention of Potent Bioactive Metabolites

J. Martín, P. Liras, 2022, Antibiotics.

The bleomycin resistance gene of transposon Tn5 is an excellent marker for transformation of corynebacteria

M. Malumbres, L. M. Mateos, J. Martín, 1992, Applied Microbiology and Biotechnology.

Characterization of an Endogenous Plasmid and Development of Cloning Vectors and a Transformation System in Brevibacterium lactofermentum

J. Martín, J. Gil, R. Santamaría, 1984 .

Vacuolal and Peroxisomal Calcium Ion Transporters in Yeasts and Fungi: Key Role in the Translocation of Intermediates in the Biosynthesis of Fungal Metabolites

J. Martín, 2022, Genes.

Efficient Transformation of the Cephamycin C Producer Nocardia lactamdurans and Development of Shuttle and Promoter-Probe Cloning Vectors

J. Martín, J. Coque, C. Kumar, 1994, Applied and environmental microbiology.

Gene Targeting in Penicillium chrysogenum: Disruption of the lys2 Gene Leads to Penicillin Overproduction

J. Martín, S. Gutiérrez, J. Casqueiro, 1999, Journal of bacteriology.

Different proteins bind to the butyrolactone receptor protein ARE sequence located upstream of the regulatory ccaR gene of Streptomyces clavuligerus

J. Martín, P. Liras, I. Santamarta, 2005, Molecular microbiology.

Cloning of genes involved in penicillin and cephalosporin biosynthesis

J. Martín, 1987 .

Characterization of the polyene macrolide P450 epoxidase from Streptomyces natalensis that converts de-epoxypimaricin into pimaricin.

J. Martín, M. V. Mendes, J. F. Aparicio, 2005, The Biochemical journal.

Genome sequencing and analysis of the filamentous fungus Penicillium chrysogenum

Andriy Kovalchuk, Kaj Albermann, Christian Wagner, 2008, Nature Biotechnology.

The inducers 1,3-diaminopropane and spermidine produce a drastic increase in the expression of the penicillin biosynthetic genes for prolonged time, mediated by the laeA regulator.

C. García-Estrada, J. Martín, R. Ullán, 2012, Fungal genetics and biology : FG & B.

Motifs in the C-terminal region of the Penicillium chrysogenum ACV synthetase are essential for valine epimerization and processivity of tripeptide formation.

C. García-Estrada, J. Martín, I. Vaca, 2012, Biochimie.

A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum

J. Martín, R. Ullán, M. Fernández-Aguado, 2012, Applied Microbiology and Biotechnology.

Amplification and disruption of the phenylacetyl-CoA ligase gene of Penicillium chrysogenum encoding an aryl-capping enzyme that supplies phenylacetic acid to the isopenicillin N-acyltransferase.

J. Martín, I. Vaca, J. Casqueiro, 2006, The Biochemical journal.

Effect of a heterotrimeric G protein alpha subunit on conidia germination, stress response, and roquefortine C production in Penicillium roqueforti.

J. Martín, R. Chávez, F. Fierro, 2009, International microbiology : the official journal of the Spanish Society for Microbiology.

Cloning and characterization of a gene ofStreptomyces griseus that increases production of extracellular enzymes in several species ofStreptomyces

J. Martín, J. Gil, A. Daza, 1990, Molecular and General Genetics MGG.

Deletion of the pyc Gene Blocks Clavulanic Acid Biosynthesis Except in Glycerol-Containing Medium: Evidence for Two Different Genes in Formation of the C3 Unit

J. Martín, P. Liras, R. Pérez-Redondo, 1999, Journal of bacteriology.

Inducing Effect of Diamines on Transcription of the Cephamycin C Genes from the lat and pcbAB Promoters inNocardia lactamdurans

J. Martín, F. Enguita, A. Leitão, 1999, Journal of bacteriology.

Improved oxygen transfer in cultures of Nocardia lactamdurans maintains the cephamycin biosynthetic proteins for prolonged time and enhances the conversion of deacetylcephalosporin into cephamycin C

J. Martín, F. Enguita, A. Leitão, 1997 .

Secondary Metabolites in Cheese Fungi

J. Martín, P. Liras, 2016 .

Biosynthesis and phosphate control of candicidin byStreptomyces acrimycini JI2236: effect of amplification of thepabAB gene

J. Martín, P. Liras, J. Asturias, 1994, Journal of Industrial Microbiology.

Silencing of a second dimethylallyltryptophan synthase of Penicillium roqueforti reveals a novel clavine alkaloid gene cluster

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Applied Microbiology and Biotechnology.

PI Factor, a Novel Type Quorum-sensing Inducer Elicits Pimaricin Production in Streptomyces natalensis*

J. Martín, E. Recio, J. F. Aparicio, 2004, Journal of Biological Chemistry.

Unsuspected control of siderophore production by N-acetylglucosamine in streptomycetes.

G. V. van Wezel, J. Martín, S. Rigali, 2012, Environmental microbiology reports.

Environmental significance of O-demethylation of chloroanisoles by soil bacterial isolates as a mechanism that improves the overall biodegradation of chlorophenols.

J. Martín, J. Coque, E. Recio, 2007, Environmental microbiology.

Characterization of an hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures

J. Martín, P. Liras, Á. Rumbero, 2006, Applied Microbiology and Biotechnology.

Analysis and validation of the pho regulon in the tacrolimus-producer strain Streptomyces tsukubaensis: differences with the model organism Streptomyces coelicolor

C. Barreiro, J. Martín, Miriam Martínez-Castro, 2018, Applied Microbiology and Biotechnology.

Proteome response of Corynebacterium glutamicum to high concentration of industrially relevant C₄ and C₅ dicarboxylic acids.

C. Barreiro, J. Martín, María F. Vasco-Cardenas, 2013, Journal of proteomics.

Transcription Factors Controlling Primary and Secondary Metabolism in Filamentous Fungi: The β-Lactam Paradigm

C. García-Estrada, J. Martín, R. Domínguez-Santos, 2018, Fermentation.

An improved HPLC assay of the substrate and products of the isopenicillin N synthase

J. Martín, J. Cortés, B. Meesschaert, 1987 .

Interconnected Set of Enzymes Provide Lysine Biosynthetic Intermediates and Ornithine Derivatives as Key Precursors for the Biosynthesis of Bioactive Secondary Metabolites

J. Martín, P. Liras, 2023, Antibiotics.

Glycopeptide resistance: Links with inorganic phosphate metabolism and cell envelope stress.

J. Martín, María Ordóñez-Robles, F. Santos-Beneit, 2017, Biochemical pharmacology.

Role of homoserine and threonine pathway intermediates as precursors for the biosynthesis of aminoethoxyvinylglycine in Streptomyces sp. NRRL 5331.

J. Martín, J. F. Aparicio, M. Fernández, 2004, Microbiology.

Characterization of the hom-thrC-thrB cluster in aminoethoxyvinylglycine-producing Streptomyces sp. NRRL 5331.

J. Martín, E. Recio, J. F. Aparicio, 2002, Microbiology.

Clusters of genes for the biosynthesis of antibiotics: Regulatory genes and overproduction of pharmaceuticals

J. Martín, 1992, Journal of Industrial Microbiology.

Evolution of the clusters of genes for β-lactam antibiotics: a model for evolutive combinatorial assembly of new β-lactams

J. Martín, P. Liras, A. Rodríguez-García, 1998 .

Characterization of the oat1 gene of Penicillium chrysogenum encoding an ω-aminotransferase: induction by L-lysine, L-ornithine and L-arginine and repression by ammonium

J. Martín, R. Ullán, J. Casqueiro, 2005, Molecular Genetics and Genomics.

Inactivation of the lys7 Gene, Encoding Saccharopine Reductase in Penicillium chrysogenum, Leads to Accumulation of the Secondary Metabolite Precursors Piperideine-6-Carboxylic Acid and Pipecolic Acid from α-Aminoadipic Acid

J. Martín, R. Ullán, J. Casqueiro, 2004, Applied and Environmental Microbiology.

Conversion of Pipecolic Acid into Lysine in Penicillium chrysogenum Requires Pipecolate Oxidase and Saccharopine Reductase: Characterization of the lys7 Gene Encoding Saccharopine Reductase

Pilar Lopez, Leopoldo Naranjo, J. Martín, 2001, Journal of bacteriology.

Blue Cheese: Microbiota and Fungal Metabolites

J. Martín, M. Coton, 2017 .

Organization of the Gene Cluster for Biosynthesis of Penicillin in Penicillium nalgiovense and Antibiotic Production in Cured Dry Sausages

J. Martín, F. Fierro, R. Cardoza, 1999, Applied and Environmental Microbiology.

Characterization of the biosynthesis in vivo of α-aminoadipyl-cysteinyl-valine inPenicillium chrysogenum

J. Martín, J. Luengo, F. Ramos, 1985, Applied Microbiology and Biotechnology.

Conversion of phenylacetyl‐cysteinyl‐valine in vitro into penicillin G by isopenicillin N synthase of Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1986 .

Phosphate Control of the Biosynthesis of Antibiotics and Other Secondary Metabolites Is Mediated by the PhoR-PhoP System: an Unfinished Story

J. Martín, Juan F. Martín, 2004, Journal of bacteriology.

Purification and Chemical Characterization of a Potent Acaricide and a Closely Related Inactive Metabolite Produced by Eurotium rubrum C47

J. Martín, P. Liras, L. Cañedo, 2020, Antibiotics.

The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control

C. Barreiro, J. Martín, G. López, 2014, Applied Microbiology and Biotechnology.

Hierarchical Control on Polyene Macrolide Biosynthesis: PimR Modulates Pimaricin Production via the PAS-LuxR Transcriptional Activator PimM

J. Martín, J. F. Aparicio, Javier Santos-Aberturas, 2012, PloS one.

Functional conservation of PAS-LuxR transcriptional regulators in polyene macrolide biosynthesis.

J. Martín, Javier Santos-Aberturas, Susana M. Guerra, 2011, Metabolic engineering.

PimT, an amino acid exporter controls polyene production via secretion of the quorum sensing pimaricin-inducer PI-factor in Streptomyces natalensis

J. Martín, Susana M. Guerra, J. F. Aparicio, 2009, Microbial cell factories.

Glycerol, ethylene glycol and propanediol elicit pimaricin biosynthesis in the PI-factor-defective strain Streptomyces natalensis npi287 and increase polyene production in several wild-type actinomycetes.

J. Martín, E. Recio, J. F. Aparicio, 2006, Microbiology.

Identification of PimR as a Positive Regulator of Pimaricin Biosynthesis in Streptomyces natalensis

J. Martín, M. V. Mendes, J. F. Aparicio, 2004, Journal of bacteriology.

Cloning and characterization of the gene cahB encoding a cephalosporin C acetylhydrolase from Acremonium chrysogenum

J. Martín, S. Gutiérrez, F. Fierro, 2001, Applied Microbiology and Biotechnology.

An efficient gene transfer system for the pimaricin producer Streptomyces natalensis.

J. Martín, S. Tunca, Susana M. Guerra, 2006, FEMS Microbiology Letters.

An e⁄cient gene transfer system for the pimaricin producer Streptomycesnatalensis

J. Martín, S. Tunca, Susana M. Guerra, 2006 .

Functional characterization of the polyketide synthase gene required for ochratoxin A biosynthesis in Penicillium verrucosum.

C. García-Estrada, J. Martín, A. Coghlan, 2013, International journal of food microbiology.

The Penicillium Chrysogenum Extracellular Proteome. Conversion from a Food-rotting Strain to a Versatile Cell Factory for White Biotechnology*

C. García-Estrada, C. Barreiro, J. Martín, 2010, Molecular & Cellular Proteomics.

Expression of the Acremonium chrysogenumcefT gene in Penicillum chrysogenum indicates that it encodes an hydrophilic β-lactam transporter

J. Martín, R. Ullán, F. Teijeira, 2008, Current Genetics.

Deacetylcephalosporin C production in Penicillium chrysogenum by expression of the isopenicillin N epimerization, ring expansion, and acetylation genes.

J. Martín, F. J. Fernández, R. Ullán, 2007, Chemistry & biology.

Unraveling the methionine-cephalosporin puzzle in Acremonium chrysogenum.

J. Martín, A. Demain, 2002, Trends in biotechnology.

Coordinate increase of isopenicillin N synthetase, isopenicillin N epimerase and deacetoxycephalosporin C synthetase in a high cephalosporin‐producing mutant of Acremonium chrysogenum and simultaneous loss of the three enzymes in a non‐producing mutant

J. Martín, F. Ramos, M. López-Nieto, 1986 .

LAL Regulators SCO0877 and SCO7173 as Pleiotropic Modulators of Phosphate Starvation Response and Actinorhodin Biosynthesis in Streptomyces coelicolor

J. Martín, A. Rodríguez-García, Susana M. Guerra, 2012, PloS one.

Molecular Control of Expression of Penicillin Biosynthesis Genes in Fungi: Regulatory Proteins Interact with a Bidirectional Promoter Region

J. Martín, 2000, Journal of bacteriology.

Characterization of an Autoinducer of Penicillin Biosynthesis in Penicillium chrysogenum

C. García-Estrada, J. Martín, R. Ullán, 2011, Applied and Environmental Microbiology.

The global regulator LaeA controls penicillin biosynthesis, pigmentation and sporulation, but not roquefortine C synthesis in Penicillium chrysogenum.

Carlos García-Estrada, Elba Mauriz, C. García-Estrada, 2009, Biochimie.

Overexpression of the Nocardia lactamduransα‐Aminoadipyl‐Cysteinyl‐Valine Synthetase in Streptomyces lividans

J. Martín, J. Coque, P. Liras, 1996 .

Streptomyces clavuligerus: The Omics Era

J. Martín, P. Liras, 2021, Journal of industrial microbiology & biotechnology.

Gene clusters for beta-lactam antibiotics and control of their expression: why have clusters evolved, and from where did they originate?

J. Martín, P. Liras, 2006, International microbiology : the official journal of the Spanish Society for Microbiology.

Clavine Alkaloids Gene Clusters of Penicillium and Related Fungi: Evolutionary Combination of Prenyltransferases, Monooxygenases and Dioxygenases

J. Martín, P. Liras, R. Álvarez-Álvarez, 2017, Genes.

A preparative method for the purification of isopenicillin N from genetically blocked Acremonium chrysogenum strain TD189: studies on the degradation kinetics and storage conditions

J. Martín, R. Chávez, I. Vaca, 2011, The Journal of Antibiotics.

Functional analysis of two divalent metal‐dependent regulatory genes dmdR1 and dmdR2 in Streptomyces coelicolor and proteome changes in deletion mutants

C. Barreiro, J. Martín, J. Coque, 2005, The FEBS journal.

RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression.

C. García-Estrada, J. Martín, I. Vaca, 2008, Journal of microbiological methods.

In vivo transport of the intermediates of the penicillin biosynthetic pathway in tailored strains of Penicillium chrysogenum

C. García-Estrada, J. Martín, I. Vaca, 2007, Applied Microbiology and Biotechnology.

Cascades and networks of regulatory genes that control antibiotic biosynthesis.

J. Martín, P. Liras, 2012, Sub-cellular biochemistry.

Control ofAntibiotic Biosynthesis

J. Martín, A. Demain, 1980 .

A squalene epoxidase is involved in biosynthesis of both the antitumor compound clavaric acid and sterols in the basidiomycete H. sublateritium.

J. Martín, R. Fouces, R. P. Godio, 2007, Chemistry & biology.

Modified oxidosqualene cyclases in the formation of bioactive secondary metabolites: biosynthesis of the antitumor clavaric acid.

J. Martín, R. P. Godio, 2009, Fungal genetics and biology : FG & B.

The crtS gene of Xanthophyllomyces dendrorhous encodes a novel cytochrome-P450 hydroxylase involved in the conversion of beta-carotene into astaxanthin and other xanthophylls.

Eduardo J. Gudiña, J. Martín, J. Barredo, 2006, Fungal genetics and biology : FG & B.

Characterization of a novel peroxisome membrane protein essential for conversion of isopenicillin N into cephalosporin C.

J. Martín, I. Vaca, R. Ullán, 2010, The Biochemical journal.

Response of the cytoplasmic and membrane proteome of Corynebacterium glutamicum ATCC 13032 to pH changes

Mónica Barriuso-Iglesias, C. Barreiro, J. Martín, 2008, BMC Microbiology.

Phosphate-dependent regulation of the low- and high-affinity transport systems in the model actinomycete Streptomyces coelicolor.

J. Martín, J. Martín, A. Rodríguez-García, 2008, Microbiology.

Secretion systems for secondary metabolites: how producer cells send out messages of intercellular communication.

J. Martín, P. Liras, J. Casqueiro, 2005, Current opinion in microbiology.

Cloning and Expression of Antibiotic Production Genes

J. Martín, J. Gil, 1984, Bio/Technology.

High transformation frequency of nonsporulating mutants of Streptomyces griseus

J. Martín, J. Gil, A. Daza, 1990 .

Calcium-containing phosphopeptides pave the secretory pathway for efficient protein traffic and secretion in fungi

J. Martín, 2014, Microbial Cell Factories.

Unraveling Nutritional Regulation of Tacrolimus Biosynthesis in Streptomyces tsukubaensis through omic Approaches

J. Martín, María Ordóñez-Robles, Fernando Santos-Beneit, 2018, Antibiotics.

Streptomyces tsukubaensis as a new model for carbon repression: transcriptomic response to tacrolimus repressing carbon sources

J. Martín, P. Liras, María Ordóñez-Robles, 2017, Applied Microbiology and Biotechnology.

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

H. Petković, C. Barreiro, J. Martín, 2012, BMC Microbiology.

Inhibition by phosphate of the activity of candicidin synthases

J. Martín, A. Demain, P. Liras, 1977 .

Allophane increases the protein levels of several cephamycin biosynthetic enzymes in Nocardia lactamdurans

J. Martín, F. Enguita, A. Leitão, 1996 .

Genome-wide transcriptome response of Streptomyces tsukubaensis to N-acetylglucosamine: effect on tacrolimus biosynthesis.

J. Martín, María Ordóñez-Robles, A. Rodríguez-García, 2018, Microbiological research.

Streptomyces clavuligerus relA-null mutants overproduce clavulanic acid and cephamycin C: negative regulation of secondary metabolism by (p)ppGpp.

M. Bibb, J. Martín, A. Hesketh, 2008, Microbiology.

An rplKΔ29‐PALG‐32 mutation leads to reduced expression of the regulatory genes ccaR and claR and very low transcription of the ceaS2 gene for clavulanic acid biosynthesis in Streptomyces clavuligerus

A. Pisabarro, J. Martín, P. Liras, 2006, Molecular microbiology.

Effects of replacement of promoters and modification of the leader peptide region of the amy gene of Streptomyces griseus on synthesis and secretion of α-amylase by Streptomyces lividans

J. Martín, J. Gil, P. Villadas, 1991, Molecular and General Genetics MGG.

Cloning, characterization and expression of an α-amylase gene from Streptomyces griseus IMRU3570

J. Martín, J. Gil, A. Daza, 1991, Molecular and General Genetics MGG.

Biosynthesis of β-lactam antibiotics: Design and construction of overproducing strains

J. Martín, P. Liras, 1985 .

REGULATION BY AROMATIC AMINO ACIDS AT THE p-AMINOBENZOIC ACID SYNTHETASE LEVEL IN S.griseus

J. Martín, J. Gil, G. Naharro, 1981 .

Transport of substrates into peroxisomes: the paradigm of β-lactam biosynthetic intermediates

C. García-Estrada, J. Martín, R. Ullán, 2013, Biomolecular concepts.

Novel genes involved in cephalosporin biosynthesis: the three-component isopenicillin N epimerase system.

J. Martín, R. Ullán, J. Casqueiro, 2004, Advances in biochemical engineering/biotechnology.

Harnessing microbiota interactions to produce bioactive metabolites: communication signals and receptor proteins.

J. Martín, P. Liras, 2019, Current opinion in pharmacology.

Molecular genetics of naringenin biosynthesis, a typical plant secondary metabolite produced by Streptomyces clavuligerus

Silvia M. Albillos, J. Martín, P. Liras, 2015, Microbial Cell Factories.

Insight into the Genome of Diverse Penicillium chrysogenum Strains: Specific Genes, Cluster Duplications and DNA Fragment Translocations

J. Martín, 2020, International journal of molecular sciences.

FK506 biosynthesis is regulated by two positive regulatory elements in Streptomyces tsukubaensis

H. Petković, C. Barreiro, J. Martín, 2012, BMC Microbiology.

Organization and Transcriptional Analysis of a Six-Gene Cluster around the rplK-rplA Operon ofCorynebacterium glutamicum Encoding the Ribosomal Proteins L11 and L1

C. Barreiro, J. Martín, Eva González-Lavado, 2001, Applied and Environmental Microbiology.

Proteomics Shows New Faces for the Old Penicillin Producer Penicillium chrysogenum

Carlos García-Estrada, C. García-Estrada, C. Barreiro, 2012, Journal of biomedicine & biotechnology.

Conversion of β-carotene into astaxanthin: Two separate enzymes or a bifunctional hydroxylase-ketolase protein?

J. Martín, J. Barredo, J. L. Barredo, 2007 .

Modulation of Gene Expression in Actinobacteria by Translational Modification of Transcriptional Factors and Secondary Metabolite Biosynthetic Enzymes

J. Martín, P. Liras, S. Sánchez, 2021, Frontiers in Microbiology.

The Balance Metabolism Safety Net: Integration of Stress Signals by Interacting Transcriptional Factors in Streptomyces and Related Actinobacteria

J. Martín, P. Liras, 2020, Frontiers in Microbiology.

Proteomics Methodology Applied to the Analysis of Filamentous Fungi - New Trends for an Impressive Diverse Group of Organisms

C. García-Estrada, C. Barreiro, J. Martín, 2012 .

A simple medium for rapid regeneration of Bacillus subtilis protoplasts transformed with plasmid DNA

J. Martín, H. Sandoval, P. López, 1987 .

Casein phosphopeptides drastically increase the secretion of extracellular proteins in Aspergillus awamori. Proteomics studies reveal changes in the secretory pathway

C. García-Estrada, C. Barreiro, J. Martín, 2012, Microbial Cell Factories.

The heterotrimeric Galpha protein pga1 regulates biosynthesis of penicillin, chrysogenin and roquefortine in Penicillium chrysogenum.

J. Martín, F. Fierro, E. Mauriz, 2008, Microbiology.

Draft Genome of Streptomyces tsukubaensis NRRL 18488, the Producer of the Clinically Important Immunosuppressant Tacrolimus (FK506)

C. Prieto, C. García-Estrada, A. Tauch, 2012, Journal of bacteriology.

Streptomyces tacrolimicus sp. nov., a low producer of the immunosuppressant tacrolimus (FK506).

C. Barreiro, J. Martín, Miriam Martínez-Castro, 2011, International journal of systematic and evolutionary microbiology.

The transport of phenylacetic acid across the peroxisomal membrane is mediated by the PaaT protein in Penicillium chrysogenum

J. Martín, R. Ullán, M. Fernández-Aguado, 2013, Applied Microbiology and Biotechnology.

A vacuolar membrane protein affects drastically the biosynthesis of the ACV tripeptide and the beta-lactam pathway of Penicillium chrysogenum

J. Martín, R. Ullán, M. Fernández-Aguado, 2012, Applied Microbiology and Biotechnology.

Fungal Secondary Metabolites in the “OMICS” Era

C. García-Estrada, J. Martín, rer. nat Susanne Zeilinger, 2015 .

Arginine boxes and the argR gene in Streptomyces clavuligerus: evidence for a clear regulation of the arginine pathway

J. Martín, P. Liras, A. Rodríguez-García, 1997, Molecular microbiology.

Metabolic Switches and Adaptations Deduced from the Proteomes of Streptomyces coelicolor Wild Type and phoP Mutant Grown in Batch Culture*

Kay Nieselt, David A. Hodgson, Nigel J. Burroughs, 2011, Molecular & Cellular Proteomics.

Competition between the GlnR and PhoP regulators for the glnA and amtB promoters in Streptomyces coelicolor

J. Martín, W. Wohlleben, A. Rodríguez-García, 2012, Nucleic acids research.

Identification of different promoters in the absA1–absA2 two-component system, a negative regulator of antibiotic production in Streptomyces coelicolor

J. Martín, A. Rodríguez-García, Fernando Santos-Beneit, 2013, Molecular Genetics and Genomics.

Phosphate control over nitrogen metabolism in Streptomyces coelicolor: direct and indirect negative control of glnR, glnA, glnII and amtB expression by the response regulator PhoP

J. Martín, Juan F. Martín, Fernando Santos-Beneit, 2009, Nucleic acids research.

Target genes and structure of the direct repeats in the DNA-binding sequences of the response regulator PhoP in Streptomyces coelicolor

J. Martín, A. Apel, A. Rodríguez-García, 2008, Nucleic acids research.

Ribosomal RNA and ribosomal proteins in corynebacteria.

C. Barreiro, J. Martín, Eva González-Lavado, 2003, Journal of biotechnology.

Changes in composition of conidia of Penicillium notatum during germination

J. Martín, P. Liras, J. R. Villanueva, 1974, Archives of Microbiology.

Binding of PhoP to promoters of phosphate‐regulated genes in Streptomyces coelicolor: identification of PHO boxes

J. Martín, A. Rodríguez-García, A. Sola-Landa, 2005, Molecular microbiology.

Streptomyces natalensis Regulator of Pimaricin Biosynthesis in Identification of PimR as a Positive

J. Martín, M. V. Mendes, J. F. Aparicio, 2004 .

Insights into the Structure and Molecular Mechanisms of β-Lactam Synthesizing Enzymes in Fungi

J. Martín, P. Liras, 2017 .

Stable transformants of the azaphilone pigment-producing Monascus purpureus obtained by protoplast transformation and Agrobacterium-mediated DNA transfer

J. Martín, S. Gutiérrez, P. Liras, 2003, Current Genetics.

Heat Shock Proteome Analysis of Wild-Type Corynebacterium glutamicum ATCC 13032 and a Spontaneous Mutant Lacking GroEL 1 , a Dispensable Chaperone

A. Tauch, C. Barreiro, J. Martín, 2005 .

Heat Shock Proteome Analysis of Wild-Type Corynebacterium glutamicum ATCC 13032 and a Spontaneous Mutant Lacking GroEL1, a Dispensable Chaperone

A. Tauch, C. Barreiro, J. Martín, 2005, Journal of bacteriology.

Retraction: Microarray studies reveal a ‘differential response’ to moderate or severe heat shock of the HrcA- and HspR-dependent systems in Corynebacterium glutamicum

J. Kalinowski, A. Hüser, C. Barreiro, 2009, Microbiology.

Expression of Streptomyces genes encoding extracellular enzymes in Brevibacterium lactofermentum: secretion proceeds by removal of the same leader peptide as in Streptomyces lividans

J. Martín, J. Gil, R. F. Cadenas, 1992, Applied Microbiology and Biotechnology.

NRPSsp: non-ribosomal peptide synthase substrate predictor

Carlos Prieto, Carlos García-Estrada, Diego Lorenzana, 2012, Bioinform..

Iron-regulatory proteins DmdR1 and DmdR2 of Streptomyces coelicolor form two different DNA-protein complexes with iron boxes.

J. Martín, Francisco J Flores, 2004, The Biochemical journal.

Phosphate control of phoA, phoC and phoD gene expression in Streptomyces coelicolor reveals significant differences in binding of PhoP to their promoter regions.

J. Martín, A. Apel, A. Rodríguez-García, 2007, Microbiology.

Phosphate and carbon source regulation of two PhoP-dependent glycerophosphodiester phosphodiesterase genes of Streptomyces coelicolor.

J. Martín, A. Apel, A. Rodríguez-García, 2009, Microbiology.

Thaumatin Production in Aspergillus awamori by Use of Expression Cassettes with Strong Fungal Promoters and High Gene Dosage

Santiago Gutierrez, J. Martín, S. Gutiérrez, 1999, Applied and Environmental Microbiology.

Characterization and nitrogen-source regulation at the transcriptional level of the gdhA gene of Aspergillus awamori encoding an NADP-dependent glutamate dehydrogenase

J. Martín, F. Fierro, S. Gutiérrez, 1998, Current Genetics.

Large amplification of a 35-kb DNA fragment carrying two penicillin biosynthetic genes in high penicillin producing strains of Penicillium chrysogenum

Emilio Alvarez, J. Martín, J. Barredo, 1989, Current Genetics.

Deoxyribonucleases of non-pathogenic corynebacteria

J. Martín, H. Sandoval, P. López, 1987 .

Characterization of the rrnB Operon of the Plant Pathogen Rhodococcus fascians and Targeted Integrations of Exogenous Genes at rrn Loci

A. Pisabarro, J. Martín, A. Correia, 1998, Applied and Environmental Microbiology.

Targeted integration of foreign genes into repetitive sequences of the Brevibacterium lactofermentum chromosome

J. Martín, J. Castro, A. Correia, 1996 .

Interaction of the Two Proteins of the Methoxylation System Involved in Cephamycin C Biosynthesis

J. Martín, J. Martín, F. Enguita, 1996, The Journal of Biological Chemistry.

Expression of the penDE gene of Penicillium chrysogenum encoding isopenicillin N acyltransferase in Cephalosporium acremonium: production of benzylpenicillin by the transformants

J. Martín, J. Barredo, B. Díez, 2004, Molecular and General Genetics MGG.

High efficiency transformation of Penicillium nalgiovense with integrative and autonomously replicating plasmids.

J. Martín, F. Fierro, F. Laich, 2004, International journal of food microbiology.

Domain structure characterization of the multifunctional alpha-aminoadipate reductase from Penicillium chrysogenum by limited proteolysis. Activation of alpha-aminoadipate does not require the peptidyl carrier protein box or the reduction domain.

J. Martín, J. F. Aparicio, M. J. Hijarrubia, 2003, The Journal of biological chemistry.

The Biosynthetic Gene Cluster for the 26-Membered Ring Polyene Macrolide Pimaricin

J. Martín, J. Martín, J F Martín, 1999, The Journal of Biological Chemistry.

Characterization of a two-gene operon epeRA involved in multidrug resistance in Streptomyces clavuligerus.

J. Martín, P. Liras, I. Santamarta, 2006, Research in microbiology.

Taxonomy and chemically semi-defined media for the analysis of the tacrolimus producer ‘Streptomyces tsukubaensis’

C. Barreiro, J. Martín, Miriam Martínez-Castro, 2013, Applied Microbiology and Biotechnology.

Biosynthetic gene clusters for relevant secondary metabolites produced by Penicillium roqueforti in blue cheeses

C. García-Estrada, J. Martín, 2016, Applied Microbiology and Biotechnology.

Evolutionary formation of gene clusters by reorganization: the meleagrin/roquefortine paradigm in different fungi

J. Martín, P. Liras, 2016, Applied Microbiology and Biotechnology.

Direct involvement of the CreA transcription factor in penicillin biosynthesis and expression of the pcbAB gene in Penicillium chrysogenum

C. García-Estrada, J. Martín, Cristina Cepeda-García, 2014, Applied Microbiology and Biotechnology.

Post-translational enzyme modification by the phosphopantetheinyl transferase is required for lysine and penicillin biosynthesis but not for roquefortine or fatty acid formation in Penicillium chrysogenum.

Carlos García-Estrada, Elba Mauriz, C. García-Estrada, 2008, The Biochemical journal.

Pulsed-Field Gel Electrophoresis Analysis of the Genome of Rhodococcus fascians: Genome Size and Linear and Circular Replicon Composition in Virulent and Avirulent Strains

A. Pisabarro, J. Martín, Antonio Correia, 1998, Current Microbiology.

Transport systems, intracellular traffic of intermediates and secretion of β-lactam antibiotics in fungi

J. Martín, 2020, Fungal Biology and Biotechnology.

Transcriptional and bioinformatic analysis of the 56.8 kb DNA region amplified in tandem repeats containing the penicillin gene cluster in Penicillium chrysogenum.

Carlos García-Estrada, Francisco Fierro, C. García-Estrada, 2006, Fungal genetics and biology : FG & B.

PcFKH1, a novel regulatory factor from the forkhead family, controls the biosynthesis of penicillin in Penicillium chrysogenum.

C. Prieto, C. García-Estrada, J. Martín, 2015, Biochimie.

Regulation of α-aminoadipyl-cysteinyl-valine, isopenicillin N synthetase, isopenicillin N isomerase and deacetoxycephalosporin C synthetase by nitrogen sources in Streptomyces lactamdurans

J. Martín, J. Cortés, J. Castro, 1985, Applied Microbiology and Biotechnology.

Transcriptomic studies of phosphate control of primary and secondary metabolism in Streptomyces coelicolor

J. Martín, N. Burroughs, K. Nieselt, 2012, Applied Microbiology and Biotechnology.

Cloning, characterization of the acyl-CoA : 6-amino penicillanic acid acyltransferase gene of Aspergillus nidulans and linkage to the isopenicillin N synthase gene

J. Martín, J. Barredo, B. Díez, 1990, Molecular and General Genetics MGG.

Casein phosphopeptides and CaCl2 increase penicillin production and cause an increment in microbody/peroxisome proteins in Penicillium chrysogenum.

C. García-Estrada, C. Barreiro, J. Martín, 2017, Journal of proteomics.

The specific transport system for lysine is fully inhibited by ammonium in Penicillium chrysogenum: An ammonium-insensitive system allows uptake in carbon-starved cells

J. Martín, S. Gutiérrez, J. Casqueiro, 2004, Antonie van Leeuwenhoek.

Isopenicillin N Synthetase of Penicillium chrysogenum, an Enzyme That Converts δ-(l-α-Aminoadipyl)-l-Cysteinyl-d-Valine to Isopenicillin N

J. Martín, F. Ramos, M. López-Nieto, 1985, Antimicrobial Agents and Chemotherapy.

Transcriptional control of the F0F1-ATP synthase operon of Corynebacterium glutamicum: SigmaH factor binds to its promoter and regulates its expression at different pH values

Mónica Barriuso-Iglesias, C. Barreiro, J. Martín, 2013, Microbial biotechnology.

The gamma-butyrolactone receptors BulR1 and BulR2 of Streptomyces tsukubaensis: tacrolimus (FK506) and butyrolactone synthetases production control

C. Barreiro, J. Martín, G. López, 2014, Applied Microbiology and Biotechnology.

Sensing and transduction of nutritional and chemical signals in filamentous fungi: Impact on cell development and secondary metabolites biosynthesis.

J. Martín, E. Ver Loren van Themaat, E. V. V. Themaat, 2019, Biotechnology advances.

Characterization and partial purification of L-asparaginase from Corynebacterium glutamicum.

J. Martín, J. Martín, J. Gil, 1990, Journal of general microbiology.

Interaction of calcium responsive proteins and transcriptional factors with the PHO regulon in yeasts and fungi

J. Martín, 2023, Frontiers in cell and developmental biology.

Cloning, expression in Streptomyces lividans and biochemical characterization of a thermostable endo-β-1,4-xylanase of Thermomonospora alba UL JB1 with cellulose-binding ability

J. Martín, J. Martín, J. Coque, 1997, Applied Microbiology and Biotechnology.

Enzymes involved in penicillin, cephalosporin and cephamycin biosynthesis.

J. Martín, J. Martín, P. Liras, 1989, Advances in biochemical engineering/biotechnology.

The NADP-dependent Glutamate Dehydrogenase Gene from the Astaxanthin Producer Xanthophyllomyces dendrorhous: Use of Its Promoter for Controlled Gene Expression

J. Martín, J. Barredo, R. P. Godio, 2009, Molecular biotechnology.

A complex multienzyme system encoded by five polyketide synthase genes is involved in the biosynthesis of the 26-membered polyene macrolide pimaricin in Streptomyces natalensis.

J. Martín, J. Martín, N. Olivera, 2000, Chemistry & biology.

Thiostrepton induced proteins in Streptomyces, Amycolatopsis and Nocardia species

J. Martín, C. Kumar, 1994 .

A Novel Heptameric Sequence (TTAGTAA) Is the Binding Site for a Protein Required for High Level Expression of pcbAB, the First Gene of the Penicillin Biosynthesis in Penicillium chrysogenum *

J. Martín, J. Martín, F. Fierro, 2000, The Journal of Biological Chemistry.

The Folate Branch of the Methionine Biosynthesis Pathway in Streptomyces lividans: Disruption of the 5,10-Methylenetetrahydrofolate Reductase Gene Leads to Methionine Auxotrophy

J. Martín, J. Coque, J. Blanco, 1998, Journal of bacteriology.

Molecular cloning of thehom—thrC—thrB cluster fromBacillus sp. ULM1: Expression of thethrC gene inEscherichia coli and corynebacteria, and evolutionary relationships of the threonine genes

M. Malumbres, L. M. Mateos, J. Martín, 2008, Folia Microbiologica.

Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.

C. García-Estrada, J. Martín, Tania Velasco-Conde, 2009, Microbiology.

STUDY OF THE MOLECULAR MECHANISM OF PHOSPHATE CONTROL OF CANDICIDIN BIOSYNTHESIS USING PHOSPHATE-DEREGULATED MUTANTS

J. Martín, J. Gil, G. Naharro, 1981 .

Transcriptional Analysis of the groES-groEL1, groEL2, and dnaK genes in Corynebacterium glutamicum: Characterization of Heat Shock-Induced Promoters

M. Pátek, C. Barreiro, J. Martín, 2004, Journal of bacteriology.

A regulatory gene (ccaR) required for cephamycin and clavulanic acid production in Streptomyces clavuligerus: amplification results in overproduction of both beta-lactam compounds

J. Martín, J. Martín, P. Liras, 1997, Journal of bacteriology.

The RNA Polymerase Omega Factor RpoZ Is Regulated by PhoP and Has an Important Role in Antibiotic Biosynthesis and Morphological Differentiation in Streptomyces coelicolor

Mónica Barriuso-Iglesias, J. Martín, Miriam Martínez-Castro, 2011, Applied and Environmental Microbiology.

NRPSsp: non-ribosomal peptide synthase substrate predictor

C. Prieto, C. García-Estrada, J. Martín, 2012, Bioinform..

Proteome Analysis of the Penicillin Producer Penicillium chrysogenum

C. García-Estrada, C. Barreiro, J. Martín, 2010, Molecular & Cellular Proteomics.

Heterotrimeric Gα protein Pga1 from Penicillium chrysogenum triggers germination in response to carbon sources and affects negatively resistance to different stress conditions.

J. Martín, F. Fierro, R. García-Rico, 2011, Fungal genetics and biology : FG & B.

RNA-silencing in Penicillium chrysogenum and Acremonium chrysogenum: validation studies using beta-lactam genes expression.

C. García-Estrada, J. Martín, R. P. Godio, 2008, Journal of Microbiological Methods.

The regulatory factor PcRFX1 controls the expression of the three genes of β-lactam biosynthesis in Penicillium chrysogenum.

C. Prieto, C. García-Estrada, J. Martín, 2012, Fungal genetics and biology : FG & B.

The transporter CefM involved in translocation of biosynthetic intermediates is essential for cephalosporin production.

C. García-Estrada, J. Martín, Susana M. Guerra, 2009, The Biochemical journal.

Characterization of the Cephalosporium acremonium pcbAB gene encoding alpha-aminoadipyl-cysteinyl-valine synthetase, a large multidomain peptide synthetase: linkage to the pcbC gene as a cluster of early cephalosporin biosynthetic genes and evidence of multiple functional domains

J. Martín, J. Martín, B. Díez, 1991, Journal of bacteriology.

Engineered biosynthesis of novel polyenes: a pimaricin derivative produced by targeted gene disruption in Streptomyces natalensis.

J. Martín, J. Martín, R. Fouces, 2001, Chemistry & biology.

Transcriptional upregulation of four genes of the lysine biosynthetic pathway by homocitrate accumulation in Penicillium chrysogenum: homocitrate as a sensor of lysine-pathway distress.

C. García-Estrada, J. Martín, Tania Velasco-Conde, 2009, Microbiology.