H. Ceulemans

发表

Structure-Based Assembly of Protein Complexes in Yeast

P. Bork, A. Gavin, C. Leutwein, 2004, Science.

Repurposing High-Throughput Image Assays Enables Biological Activity Prediction for Drug Discovery.

Anne E Carpenter, Yolanda T. Chong, S. Hochreiter, 2018, Cell chemical biology.

The relationship between sequence and interaction divergence in proteins.

R. Russell, P. Aloy, A. Stark, 2003, Journal of molecular biology.

Fast fitting of atomic structures to low-resolution electron density maps by surface overlap maximization.

R. Russell, H. Ceulemans, R. Russell, 2004, Journal of molecular biology.

Multi-Task Deep Networks for Drug Target Prediction

Thomas Unterthiner, J. Wegner, G. Klambauer, 2015 .

Aiding Drug Design with Deep Neural Networks

Thomas Unterthiner, J. Wegner, G. Klambauer, 2015 .

Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

S. Aerts, H. Ceulemans, V. Christiaens, 2017, Genome Medicine.

Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

S. Aerts, H. Ceulemans, V. Christiaens, 2017, bioRxiv.

Determinants of the nucleolar targeting of protein phosphatase‐1

M. Bollen, Bart Lesage, H. Ceulemans, 2005, FEBS letters.

High-resolution profiling of the LEDGF/p75 chromatin interaction in the ENCODE region

H. Ceulemans, R. Gijsbers, Z. Debyser, 2009, Nucleic acids research.

A novel glycogen‐targeting subunit of protein phosphatase 1 that is regulated by insulin and shows differential tissue distribution in humans and rodents

M. Bollen, H. Ceulemans, S. Munro, 2005, The FEBS journal.

Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

Hinrich W. H. Göhlmann, Jean-Marc Neefs, Yolanda T. Chong, 2020, Scientific Reports.

Tales of 1,008 small molecules: phenomic profiling through live-cell imaging in a panel of reporter cell lines

Yolanda T. Chong, J. Neefs, Michael J. Cox, 2020, Scientific Reports.

Binding of the Concave Surface of the Sds22 Superhelix to the α4/α5/α6-Triangle of Protein Phosphatase-1*

M. Bollen, H. Ceulemans, M. de Maeyer, 2002, The Journal of Biological Chemistry.

Glypican-6, a New Member of the Glypican Family of Cell Surface Heparan Sulfate Proteoglycans*

P. Marynen, J. Vermeesch, H. Ceulemans, 1999, The Journal of Biological Chemistry.

Virology analyses of HCV isolates from genotype 1-infected patients treated with simeprevir plus peginterferon/ribavirin in Phase IIb/III studies.

H. Ceulemans, M. Peeters, O. Lenz, 2015, Journal of hepatology.

Atom‐to‐atom Mapping: A Benchmarking Study of Popular Mapping Algorithms and Consensus Strategies

Arkadii I. Lin, H. Ceulemans, A. Varnek, 2020, Molecular informatics.

The translation initiation factor eIF2β is an interactor of protein phosphatase-1

M. Bollen, H. Ceulemans, M. Beullens, 2006 .

Industry-Scale Orchestrated Federated Learning for Drug Discovery

Lewis H. Mervin, Adam Arany, Y. Moreau, 2022, ArXiv.

Binding of the concave surface of the Sds22 superhelix to the alpha 4/alpha 5/alpha 6-triangle of protein phosphatase-1.

M. Bollen, H. Ceulemans, M. de Maeyer, 2002, The Journal of biological chemistry.

Molecular Polymorphism of the Syndecans

H. Ceulemans, S. Vekemans, G. David, 1999, The Journal of Biological Chemistry.

Industry-Scale Orchestrated Federated Learning for Drug Discovery

Lewis H. Mervin, Y. Moreau, A. Schuffenhauer, 2022, AAAI.

Fast semi-supervised discriminant analysis for binary classification of large data-sets

Yves Moreau, Jörg K. Wegner, Karl Meerbergen, 2017, Pattern Recognit..

Nucleotide Pyrophosphatases/Phosphodiesterases on the Move

M. Bollen, H. Ceulemans, R. Gijsbers, 2000, Critical reviews in biochemistry and molecular biology.

Structural and Catalytic Similarities between Nucleotide Pyrophosphatases/Phosphodiesterases and Alkaline Phosphatases*

M. Bollen, H. Ceulemans, R. Gijsbers, 2001, The Journal of Biological Chemistry.

Replication capacity of minority variants in viral populations can affect the assessment of resistance in HCV chimeric replicon phenotyping assays.

H. Ceulemans, J. Neyts, O. Lenz, 2012, The Journal of antimicrobial chemotherapy.

Structural basis for the high Ca2+ affinity of the ubiquitous SERCA2b Ca2+ pump

H. Ceulemans, M. de Maeyer, P. Vangheluwe, 2009, Proceedings of the National Academy of Sciences.

Functional diversity of protein phosphatase-1, a cellular economizer and reset button.

M. Bollen, H. Ceulemans, 2004, Physiological reviews.

Structure and splice products of the human gene encoding sds22, a putative mitotic regulator of protein phosphatase-1.

M. Bollen, H. Ceulemans, M. Beullens, 1999, European journal of biochemistry.

The transcriptional repressor NIPP1 is an essential player in EZH2-mediated gene silencing

M. Bollen, H. Ceulemans, P. Hummelen, 2008, Oncogene.

Industry-scale application and evaluation of deep learning for drug target prediction

Thomas J. Ashby, Nina Jeliazkova, Ola Engkvist, 2020, Journal of Cheminformatics.

Large-scale comparison of machine learning methods for drug target prediction on ChEMBL† †Electronic supplementary information (ESI) available: Overview, Data Collection and Clustering, Methods, Results, Appendix. See DOI: 10.1039/c8sc00148k

Hugo Ceulemans, Sepp Hochreiter, Günter Klambauer, 2018, Chemical science.

The guanine-nucleotide-exchange factor P-Rex1 is activated by protein phosphatase 1α.

M. Bollen, H. Ceulemans, D. Oxley, 2012, The Biochemical journal.

Human UBN1 Is an Ortholog of Yeast Hpc2p and Has an Essential Role in the HIRA/ASF1a Chromatin-Remodeling Pathway in Senescent Cells

H. Ceulemans, Rugang Zhang, David Schultz, 2008, Molecular and Cellular Biology.

Macau: Scalable Bayesian factorization with high-dimensional side information using MCMC

Yves Moreau, Jörg K. Wegner, Vladimir I. Chupakhin, 2017, 2017 IEEE 27th International Workshop on Machine Learning for Signal Processing (MLSP).

Image-based profiling for drug discovery: due for a machine-learning upgrade?

Anne E Carpenter, H. Ceulemans, S. Chandrasekaran, 2020, Nature reviews. Drug discovery.

Functional characterization of the non-catalytic ectodomains of the nucleotide pyrophosphatase/phosphodiesterase NPP1.

M. Bollen, H. Ceulemans, R. Gijsbers, 2003, The Biochemical journal.

ExCAPE-DB: an integrated large scale dataset facilitating Big Data analysis in chemogenomics

Lars Carlsson, Jörg K. Wegner, Thomas J. Ashby, 2017, Journal of Cheminformatics.

Identification of cis-regulatory mutations generating de novo edges in personalized cancer gene regulatory networks

S. Aerts, H. Ceulemans, V. Christiaens, 2017, bioRxiv.

Regulator-driven functional diversification of protein phosphatase-1 in eukaryotic evolution.

M. Bollen, H. Ceulemans, W. Stalmans, 2002, BioEssays : news and reviews in molecular, cellular and developmental biology.

A Yeast Exosome Cofactor, Mpp6, Functions in RNA Surveillance and in the Degradation of Noncoding RNA Transcripts

D. Tollervey, H. Ceulemans, J. Rappsilber, 2008, Molecular and Cellular Biology.

Geminate Structures of African Cassava Mosaic Virus

R. Russell, B. Böttcher, H. Ceulemans, 2004, Journal of Virology.

Docking motif-guided mapping of the interactome of protein phosphatase-1.

M. Bollen, Bart Lesage, H. Ceulemans, 2009, Chemistry & biology.

High‐Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action

S. Lonial, G. Vanhoof, H. Ceulemans, 2018, Cytometry. Part A : the journal of the International Society for Analytical Cytology.

Syddansk Universitet High-Parameter Mass Cytometry Evaluation of Relapsed / Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action

S. Lonial, G. Vanhoof, H. Ceulemans, 2019 .

Substrate Specificity and Activity Regulation of Protein Kinase MELK*

M. Bollen, H. Ceulemans, N. Morrice, 2005, Journal of Biological Chemistry.

A capping domain for LRR protein interaction modules

M. Bollen, H. Ceulemans, M. de Maeyer, 1999, FEBS letters.

Deep immune profiling of patients treated with lenalidomide and dexamethasone with or without daratumumab

G. Vanhoof, H. Ceulemans, T. Plesner, 2020, Leukemia.

Approaches to defining the ancestral eukaryotic protein complexome.

M. Bollen, H. Ceulemans, L. Beke, 2006, BioEssays : news and reviews in molecular, cellular and developmental biology.

A tighter RVxF motif makes a finer Sift.

M. Bollen, H. Ceulemans, 2006, Chemistry & biology.

Degeneracy and Function of the Ubiquitous RVXF Motif That Mediates Binding to Protein Phosphatase-1*

M. Bollen, H. Ceulemans, M. Beullens, 2003, Journal of Biological Chemistry.

The translation initiation factor eIF2beta is an interactor of protein phosphatase-1.

M. Bollen, H. Ceulemans, M. Beullens, 2006, The Biochemical journal.

Repurposed high-throughput images enable biological activity prediction for drug discovery

Anne E Carpenter, Yves Moreau, Anne E. Carpenter, 2017, bioRxiv.

Development and implementation of an enterprise-wide predictive model for early absorption, distribution, metabolism and excretion properties.

R. DesJarlais, H. Ceulemans, V. Chupakhin, 2021, Future medicinal chemistry.

BIGL: Biochemically Intuitive Generalized Loewe null model for prediction of the expected combined effect compatible with partial agonism and antagonism

Olivier Thas, Bie Verbist, Bie M. P. Verbist, 2017, Scientific Reports.

An Essential Oligomannosidic Glycan Chain in the Catalytic Domain of Autotaxin, a Secreted Lysophospholipase-D*

M. Bollen, N. Callewaert, H. Ceulemans, 2007, Journal of Biological Chemistry.

High-Throughput Gene Expression Profiles to Define Drug Similarity and Predict Compound Activity.

Hugo Ceulemans, Hinrich Göhlmann, Hans De Wolf, 2018, Assay and drug development technologies.

University of Southern Denmark High-Parameter Mass Cytometry Evaluation of Relapsed/Refractory Multiple Myeloma Patients Treated with Daratumumab Demonstrates Immune Modulation as a Novel Mechanism of Action

S. Lonial, G. Vanhoof, H. Ceulemans, 2019 .

Highly Scalable Tensor Factorization for Prediction of Drug-Protein Interaction Type

Yves Moreau, Hugo Ceulemans, Jaak Simm, 2015, NIPS 2015.

Macau: Scalable Bayesian Multi-relational Factorization with Side Information using MCMC

Yves Moreau, Hugo Ceulemans, Jaak Simm, 2015, 1509.04610.

JUMP Cell Painting dataset: morphological impact of 136,000 chemical and genetic perturbations

Anne E Carpenter, Lewis H. Mervin, Patrick W. Faloon, 2023, bioRxiv.

Abstract LB-329: Identification of alternative mechanisms of resistance to FGFR inhibitor treatment in FGFR1-amplified large cell compared to FGFR1-amplified small cell lung cancer models

H. Ceulemans, J. Vialard, T. Perera, 2014 .

Large-scale comparison of machine learning methods for drug target prediction on ChEMBL

S. Hochreiter, Thomas Unterthiner, Djork-Arné Clevert, 2018, Chemical science.

Docking motif-guided mapping of the interactome of protein phosphatase-1.

M. Bollen, Bart Lesage, H. Ceulemans, 2009, Chemistry & biology.

Image-based profiling for drug discovery: due for a machine-learning upgrade?

Anne E Carpenter, H. Ceulemans, S. Chandrasekaran, 2020, Nature Reviews Drug Discovery.

Analysis of genotype 2 and 3 hepatitis C virus variants in patients treated with telaprevir demonstrates a consistent resistance profile across genotypes

H. Ceulemans, G. Foster, M. Beumont, 2013, Journal of viral hepatitis.

High-Parameter Mass Cytometry (CyTOF) Evaluation of Relapsed/Refractory Multiple Myeloma (MM) Pts (Pts) Treated with Daratumumab Supports Immune Modulation As a Novel Mechanism of Action

S. Lonial, G. Vanhoof, H. Ceulemans, 2016 .

Reaction Data Curation I: Chemical Structures and Transformations Standardization

Arkadii I. Lin, H. Ceulemans, A. Varnek, 2021, Molecular informatics.