J. Wikel

发表

Three- and four-dimensional quantitative structure activity relationship analyses of cytochrome P-450 3A4 inhibitors.

S. Ekins, G. Bravi, S. Binkley, 1999, The Journal of pharmacology and experimental therapeutics.

Three-dimensional quantitative structure-activity relationship for inhibition of human ether-a-go-go-related gene potassium channel.

W. Crumb, S. Ekins, J. Wikel, 2002, The Journal of pharmacology and experimental therapeutics.

Three-dimensional quantitative structure-activity relationships of inhibitors of P-glycoprotein.

S. Ekins, R. Kim, J. Wikel, 2002, Molecular pharmacology.

Application of three-dimensional quantitative structure-activity relationships of P-glycoprotein inhibitors and substrates.

S. Ekins, R. Kim, J. Wikel, 2002, Molecular pharmacology.

Three-dimensional-quantitative structure activity relationship analysis of cytochrome P-450 3A4 substrates.

S. Ekins, G. Bravi, J. Wikel, 1999, The Journal of pharmacology and experimental therapeutics.

Three- and four-dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2C9 inhibitors.

S. Ekins, G. Bravi, S. Binkley, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Depletion of cardiac norepinephrine in rats and mice by 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP).

J. Wikel, R. Fuller, H. Snoddy, 1984, Biochemical pharmacology.

QSAR study of ortho-phenylphenol leukotriene B4 receptor antagonists

J. Wikel, K. Bemis, M. Sofia, 1994 .

1,2-Dibenzamidobenzene inhibitors of human factor Xa.

J. A. Kyle, J. Wikel, B. Eastwood, 2000, Journal of medicinal chemistry.

1,2-Dibenzamidobenzene inhibitors of human factor Xa.

J. A. Kyle, J. Wikel, B. Eastwood, 2000, Journal of medicinal chemistry.

Acyl sulfonamide anti-proliferatives: benzene substituent structure-activity relationships for a novel class of antitumor agents.

G. Durst, P. Hipskind, B. Teicher, 2004, Journal of medicinal chemistry.

Synthesis of syn and anti isomers of 6-[[(hydroxyimino)phenyl]methyl]-1-[(1-methylethyl)sulfonyl]-1H-benzimidazol-2-amine. Inhibitors of rhinovirus multiplication.

J. Wikel, A. Dinner, N. D. Jones, 1980, Journal of medicinal chemistry.

Development of dual-acting agents for thromboxane receptor antagonism and thromboxane synthase inhibition. 3. Synthesis and biological activities of oxazolecarboxamide-substituted omega-phenyl-omega-(3-pyridyl)alkenoic acid derivatives and related compounds.

J. Wikel, K. Takeuchi, J. A. Jakubowski, 1998, Journal of medicinal chemistry.

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.

J. Wikel, J. Morin, J. Mccowan, 1997, Journal of medicinal chemistry.

3-Phenyl-4-hydroxyquinolin-2(1H)-ones: potent and selective antagonists at the strychnine-insensitive glycine site on the N-methyl-D-aspartate receptor complex.

D. Lodge, E. Pralong, J. Wikel, 1992, Journal of medicinal chemistry.

Dibasic benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors. 2. Exploring interactions at the proximal (S2) binding site.

J. Wikel, N. Chirgadze, S. Briggs, 1998, Bioorganic & medicinal chemistry letters.

LY249933: A Cardioselective 1,4‐Dihydropyridine with Positive Inotropic Activity

J. Wikel, J. K. Smallwood, R. Kauffman, 1989, Journal of cardiovascular pharmacology.

A convenient synthesis of the thieno[3,2‐c]pyridine nucleus

J. Wikel, R. Vasileff, M. L. Denney, 1993 .

Identification and Characterization of New Chemical Entities Targeting Apurinic/Apyrimidinic Endonuclease 1 for the Prevention of Chemotherapy-Induced Peripheral Neuropathy

J. Wikel, K. Pollok, M. Kelley, 2016, The Journal of Pharmacology and Experimental Therapeutics.

Identification of new chemical entities targeting APE1 for the prevention of chemotherapy-induced peripheral neuropathy (CIPN)

J. Wikel, K. Pollok, M. Kelley, 2016 .

Influence of molecular structure on substrate binding to the human organic cation transporter, hOCT1.

S. Ekins, S. Wright, J. Wikel, 2003, Molecular pharmacology.

The use of neural networks for variable selection in QSAR

James H. Wikel, J. Wikel, E. Dow, 1993 .

Effects of Antipsychotic Drugs on Ito, INa, Isus, IK1, and hERG: QT Prolongation, Structure Activity Relationship, and Network Analysis

Sean Ekins, R. Dustan Sarazan, Charles M. Beasley, 2006, Pharmaceutical Research.

Experimental Designs for Selecting Molecules from Large Chemical Databases

Ian A. Watson, James H. Wikel, Richard E. Higgs, 1997, J. Chem. Inf. Comput. Sci..

Progress in predicting human ADME parameters in silico.

S. Ekins, P. Swaan, J. Wikel, 2000, Journal of pharmacological and toxicological methods.

Three and four dimensional-quantitative structure activity relationship (3D/4D-QSAR) analyses of CYP2D6 inhibitors.

S. Ekins, G. Bravi, S. Binkley, 1999, Pharmacogenetics.

Ref-1/APE1 Inhibition with Novel Small Molecules Blocks Ocular Neovascularization

T. Corson, J. Wikel, M. Kelley, 2018, The Journal of Pharmacology and Experimental Therapeutics.

Identification and characterization of new chemical entities targeting APE 1 for the prevention of chemotherapy-induced peripheral neuropathy ( CIPN )

Randy, J. Wikel, K. Pollok, 2016 .

A Drug Candidate Design Environment Using Evolutionary Computation

Eric Bonabeau, M. Ihsan Ecemis, J. Wikel, 2008, IEEE Transactions on Evolutionary Computation.

Three-Dimensional-Quantitative Structure Activity Relationship Analysis of Cytochrome P-450 3 A 4 Substrates

S. Ekins, G. Bravi, J. Wikel, 1999 .

Three-dimensional quantitative structure activity relationship analyses of substrates for CYP2B6.

S. Ekins, G. Bravi, J. Gillespie, 1999, The Journal of pharmacology and experimental therapeutics.

Three-Dimensional Quantitative Structure Activity Relationship Analyses of Substrates for CYP 2 B 6

S. Ekins, G. Bravi, J. Gillespie, 1998 .

QSAR study of benzoquinolinones as inhibitors of human type 1 5-α-reductase.

Charles David Jones, James H. Wikel, Kerry G. Bemis, 1993 .

Synthesis of s-triazole[3,4-b]benzothiazoles

J. Wikel, C. Paget, 1974 .

SYNTHESIS OF S-TRIAZOLO(3,4-B)BENZOTHIAZOLES

J. Wikel, C. Paget, 1975 .

Diamino benzo[b]thiophene derivatives as a novel class of active site directed thrombin inhibitors: 3. Enhancing activity by imposing conformational restriction in the C-4" side chain.

J. Wikel, N. Chirgadze, D. Gifford-Moore, 1999, Bioorganic & medicinal chemistry letters.

Three-Dimensional Quantitative Structure-Permeability Relationship Analysis for a Series of Inhibitors of Rhinovirus Replication

Sean Ekins, David A. Thorner, Richard A. Lewis, 2001, J. Chem. Inf. Comput. Sci..