J. Taylor

发表

Axonal Transport of TDP-43 mRNA Granules Is Impaired by ALS-Causing Mutations

K. Eggan, T. Maniatis, C. Shaw, 2014, Neuron.

Interactome Mapping Provides a Network of Neurodegenerative Disease Proteins and Uncovers Widespread Protein Aggregation in Affected Brains.

Martin H. Schaefer, R. Sharan, Martina Zenkner, 2020, Cell reports.

Pediatric Cancer Variant Pathogenicity Information Exchange (PeCanPIE): a cloud-based platform for curating and classifying germline variants

Aman N. Patel, J. Downing, M. Edmonson, 2018, bioRxiv.

CREB-binding protein sequestration by expanded polyglutamine.

K. Fischbeck, H. Paulson, G. Sobue, 2000, Human molecular genetics.

Toxic Proteins in Neurodegenerative Disease

K. Fischbeck, J. Hardy, J. Taylor, 2002, Science.

VCP/p97 is essential for maturation of ubiquitin-containing autophagosomes and this function is impaired by mutations that cause IBMPFD

J. Taylor, V. Kimonis, T. Yao, 2010, Autophagy.

CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

Peter K. Todd, Ryan E. Mills, Venkatesha Basrur, 2013, Neuron.

Aggresomes protect cells by enhancing the degradation of toxic polyglutamine-containing protein.

Fumiaki Tanaka, K. Fischbeck, J. Taylor, 2003, Human molecular genetics.

hnRNPDL Phase Separation Is Regulated by Alternative Splicing and Disease-Causing Mutations Accelerate Its Aggregation

X. Salvatella, J. Taylor, S. Ventura, 2020, Cell reports.

Decoding ALS: from genes to mechanism

Robert H. Brown, J. Taylor, D. Cleveland, 2016, Nature.

Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes

John L Cleveland, Masaaki Komatsu, Katsuhiko Kitamoto, 2008, Autophagy.

RNA That Gets RAN in Neurodegeneration

J. Taylor, 2013, Science.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Autophagy and the ubiquitin-proteasome system: collaborators in neuroprotection.

J. Taylor, P. Todd, Natalia B. Nedelsky, 2008, Biochimica et biophysica acta.

HDAC6 rescues neurodegeneration and provides an essential link between autophagy and the UPS

Dan Garza, Zhiping Nie, Eric H. Baehrecke, 2007, Nature.

Archetypal and new families with Alexander disease and novel mutations in GFAP.

J. Taylor, S. Naidu, A. Messing, 2012, Archives of neurology.

Axonal transport of TDP-43 mRNA granules in neurons is impaired by ALS-causing mutations

K. Eggan, T. Maniatis, C. Shaw, 2014 .

Revealing the Mutational Spectrum in Southern Africans With Amyotrophic Lateral Sclerosis

N. Mulder, E. Rampersaud, M. Benatar, 2022, Neurology: Genetics.

Machine learning suggests polygenic contribution to cognitive dysfunction in amyotrophic lateral sclerosis

J. Gee, J. Trojanowski, M. Grossman, 2020 .

HDAC6 controls autophagosome maturation essential for ubiquitin‐selective quality‐control autophagy

J. Taylor, Joo-Yong Lee, T. Yao, 2010, The EMBO journal.

Specific heterozygous frameshift variants in hnRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy

Courtney E. French, F. Muntoni, M. Tarnopolsky, 2021, medRxiv.

The Role of Autophagy in Age-Related Neurodegeneration

J. Taylor, Brett A. McCray, J. Taylor, 2007, Neurosignals.

Ubiquitination is essential for recovery of cellular activities following heat shock

Brian A. Maxwell, J. Taylor, Hongjoo Kim, 2021, bioRxiv.

A Novel Conserved Isoform of the Ubiquitin Ligase UFD2a/UBE4B Is Expressed Exclusively in Mature Striated Muscle Cells

A. Mammen, Nisha M. Badders, J. Taylor, 2011, PloS one.

Rare Inherited forms of Paget’s Disease and Related Syndromes

J. Taylor, S. Ralston, 2019, Calcified Tissue International.

Network Analyses Reveal Novel Aspects of ALS Pathogenesis

J. Taylor, Andrea Chai, G. Pennetta, 2015, PLoS genetics.

G3BP1 Is a Tunable Switch that Triggers Phase Separation to Assemble Stress Granules

Hong Joo Kim, J. Taylor, T. Mittag, 2020, Cell.

Drosophila and Mouse Models of Hereditary Myopathy Caused by Mutations in VCP/p97

Nisha M. Badders, J. Taylor, J. Taylor, 2011 .

Convergence of Parkin, PINK1, and α-Synuclein on Stress-induced Mitochondrial Morphological Remodeling*

K. Lim, J. Taylor, Chun‐Hsiang Lai, 2015, The Journal of Biological Chemistry.

ULK1/2 Regulates Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97

Brian A. Maxwell, Shondra M. Pruett-Miller, J. Taylor, 2019 .

ULK1 and ULK2 Regulate Stress Granule Disassembly Through Phosphorylation and Activation of VCP/p97.

Brian A. Maxwell, Shondra M. Pruett-Miller, J. Taylor, 2019, Molecular cell.

Identification of compound heterozygous variants in OPTN in an ALS-FTD patient from the CReATe consortium: a case report

E. Rampersaud, M. Benatar, J. Wuu, 2018, Amyotrophic lateral sclerosis & frontotemporal degeneration.

Multisystem proteinopathy

J. Taylor, J. Taylor, 2015, Neurology.

The Aetiologic Spectrum of Cerebellar Ataxia: Acquired Causes of Ataxia

J. Taylor, P. Todd, 2009 .

Transgenic mice expressing mutant forms VCP/p97 recapitulate the full spectrum of IBMPFD including degeneration in muscle, brain and bone.

A. Wright, J. Taylor, Hongbo Lu, 2010, Human molecular genetics.

Ubiquitination of G3BP1 mediates stress granule disassembly in a context-specific manner

Brian A. Maxwell, J. Taylor, Hongjoo Kim, 2021, Science.

proteinopathy for ALS

M. Benatar, H. Katzen, J. Taylor, 2013 .

Motor neuron involvement in multisystem proteinopathy

M. Benatar, J. Wuu, H. Katzen, 2013, Neurology.

Pathological phase transitions in ALS-FTD impair dynamic RNA–protein granules

J. Taylor, Natalia B. Nedelsky, J. Taylor, 2021, RNA.

Enhanced stress tolerance through reduction of G3BP and suppression of stress granules

Shondra M. Pruett-Miller, J. Taylor, T. Lord, 2020, bioRxiv.

Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS

Emily A. Scarborough, J. Trojanowski, A. Pestronk, 2013 .

Altered “ Ribostasis ” : RNA-protein granule formation or persistence in the development of degenerative disorders

M. Ramaswami, R. Parker, J. Taylor, 2013 .

Chronic optogenetic induction of stress granules is cytotoxic and reveals the evolution of ALS-FTD pathology

J. Taylor, Hongjoo Kim, J. Temirov, 2019, eLife.

Stress Granule Assembly Disrupts Nucleocytoplasmic Transport

J. Rothstein, A. Gitler, J. Taylor, 2018, Cell.

Clinical and neuropathological features of ALS/FTD with TIA1 mutations

M. Mesulam, D. Dickson, E. Bigio, 2017, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Ubiquitination of G3BP1 mediates stress granule disassembly in a stress-specific manner

Brian A. Maxwell, J. Taylor, Hongjoo Kim, 2021, bioRxiv.

Abnormal distribution of heterogeneous nuclear ribonucleoproteins in sporadic inclusion body myositis

S. Greenberg, J. Taylor, A. Amato, 2014, Neuromuscular Disorders.

Genetic interaction of hnRNPA2B1 and DNAJB6 in a Drosophila model of multisystem proteinopathy.

Brian D. Freibaum, A. Kanagaraj, J. Taylor, 2016, Human molecular genetics.

Dominant toxicity of ALS–FTD-associated CHCHD10S59L is mediated by TDP-43 and PINK1

G. Dorn, J. Taylor, Nam Chul Kim, 2019, bioRxiv.

Neurodegenerative diseases: G-quadruplex poses quadruple threat

J. Taylor, 2014, Nature.

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Sonja W. Scholz, Janel O. Johnson, D. Hernandez, 2010, Neuron.

A case of familial ALS due to multi-system proteinopathy 1 and Huntington disease

M. Benatar, J. Taylor, V. Wheelock, 2015, Amyotrophic lateral sclerosis & frontotemporal degeneration.

No mutations in hnRNPA1 and hnRNPA2B1 in Dutch patients with amyotrophic lateral sclerosis, frontotemporal dementia, and inclusion body myopathy

P. Scheltens, F. Baas, J. Veldink, 2014, Neurobiology of Aging.

TDP-43 Mediates Degeneration in a Novel Drosophila Model of Disease Caused by Mutations in VCP/p97

J. Trojanowski, V. Lee, Brian D. Freibaum, 2010, The Journal of Neuroscience.

Genome-wide Analyses Identify KIF5A as a Novel ALS Gene in and for Therapeutic

Timothy A. Miller, Denis C. Bauer, Shankaracharya, 2018 .

transactivation by Tat. vitro and facilitates TAR-independent immunodeficiency virus type 1 transcription in kappa B-binding activity that enhances human Central nervous system-derived cells express a

F. Kashanchi, J. Taylor, J. Brady, 2013 .

Regulation of the human neurotropic virus promoter by JCV-T antigen and HIV-1 tat protein.

J. Taylor, K. Khalili, S. Amini, 1990, Oncogene.

Translational Repression of G3BP in Cancer and Germ Cells Suppresses Stress Granules and Enhances Stress Tolerance.

Shondra M. Pruett-Miller, J. Taylor, T. Lord, 2020, Molecular cell.

High-fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

Brian D. Freibaum, J. Taylor, Hongjoo Kim, 2021, The Journal of cell biology.

High fidelity reconstitution of stress granules and nucleoli in mammalian cellular lysate

Brian D. Freibaum, J. Taylor, Hongjoo Kim, 2020, bioRxiv.

Rare Inherited forms of Paget’s Disease and Related Syndromes

J. Taylor, S. Ralston, J. Taylor, 2019, Calcified Tissue International.

OptoGranules reveal the evolution of stress granules to ALS-FTD pathology

J. Taylor, Hongjoo Kim, J. Temirov, 2018, bioRxiv.

Jcb: Report

K. Lim, J. Taylor, Joo-Yong Lee, 2022 .

Evidence of activity-dependent withdrawal of corticospinal projections during human development

S. Miller, John-Paul Taylor, J. Taylor, 2001, Neurology.

A screen for drugs that protect against the cytotoxicity of polyglutamine-expanded androgen receptor.

K. Fischbeck, J. Taylor, F. Piccioni, 2003, Human molecular genetics.

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Michelle K. Cahill, Robert V Farese, W. Seeley, 2020, Nature.

Novel mutations expand the clinical spectrum of DYNC1H1-associated spinal muscular atrophy

F. Baas, E. Mercuri, F. Muntoni, 2019 .

Higher‐order oligomerization promotes localization of SPOP to liquid nuclear speckles

J. Taylor, Jihun Lee, M. Sharon, 2016, The EMBO journal.

A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43.

Ji Han Kim, Rebecca B. Smith, J. Taylor, 2011, Human molecular genetics.

Safety, tolerability, and pharmacokinetics of high-dose idebenone in patients with Friedreich ataxia.

K. Fischbeck, B. Ravina, J. Taylor, 2007, Archives of neurology.

Rescue of polyglutamine-mediated cytotoxicity by double-stranded RNA-mediated RNA interference.

A. Fire, N. Caplen, J. Taylor, 2002, Human molecular genetics.

FOXO3a Is Broadly Neuroprotective In Vitro and In Vivo against Insults Implicated in Motor Neuron Diseases

R. Kalb, M. Driscoll, R. Neve, 2009, The Journal of Neuroscience.

Molecular heterogeneity and CXorf67 alterations in posterior fossa group A (PFA) ependymomas

David T. W. Jones, M. Roussel, M. Kool, 2018, Acta Neuropathologica.

Activation of expression of genes coding for extracellular matrix proteins in Tat-producing glioblastoma cells.

S. Jimenez, J. Taylor, K. Khalili, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Dynamic mapping of proteome trafficking within and between living cells by TransitID

Brian D. Freibaum, J. Taylor, A. Ting, 2023, bioRxiv.

Exome sequencing in amyotrophic lateral sclerosis implicates a novel gene, DNAJC7, encoding a heat-shock protein

Ahmad Al Khleifat, M. Nalls, M. Daly, 2019, Nature Neuroscience.

Overexpression of IGF-1 in Muscle Attenuates Disease in a Mouse Model of Spinal and Bulbar Muscular Atrophy

K. Fischbeck, A. Musarò, G. Sobue, 2009, Neuron.

C9orf72 Dipeptide Repeats Impair the Assembly, Dynamics, and Function of Membrane-Less Organelles

Diana M. Mitrea, Brian A. Maxwell, Brian D. Freibaum, 2016, Cell.

Disease mutations in Rab7 result in unregulated nucleotide exchange and inappropriate activation

E. Skordalakes, J. Taylor, Brett A. McCray, 2009, Human molecular genetics.

Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic mice

David I. Bass, G. Schellenberg, M. Farrer, 2010, Neurobiology of Disease.

Genome-wide Analyses Id entify KIF 5 A as a Novel ALS Gene Highlights

Sonja W. Scholz, Janel O. Johnson, D. Hernandez, 2018 .

Repeat expansion disease: progress and puzzles in disease pathogenesis

J. Taylor, A. Spada, J. Paul Taylor, 2010, Nature Reviews Genetics.

Global analysis of TDP-43 interacting proteins reveals strong association with RNA splicing and translation machinery.

R. Chitta, Brian D. Freibaum, J. Taylor, 2010, Journal of proteome research.

Altered Ribostasis: RNA-Protein Granules in Degenerative Disorders

Mani Ramaswami, Roy Parker, M. Ramaswami, 2013, Cell.

A murine model of hnRNPH2-related neurodevelopmental disorder recapitulates clinical features of human disease and reveals a mechanism for genetic compensation of HNRNPH2

J. Taylor, Y. Chook, K. O’Donovan, 2022, bioRxiv.

Characterization of HNRNPA1 mutations defines diversity in pathogenic mechanisms and clinical presentation

M. Wheeler, J. Taylor, Lin Guo, 2021, JCI insight.

DEFINING THE DIVERSITY OF HNRNPA1 MUTATIONS IN CLINICAL PHENOTYPE AND PATHOMECHANISM

H. J. Kim, M. Wheeler, J. Taylor, 2021, medRxiv.

Prion-like domain mutations in hnRNPs cause multisystem proteinopathy and ALS

Michael Benatar, Steven A Greenberg, Aaron D Gitler, 2013, Nature.

Heterozygous frameshift variants in HNRNPA2B1 cause early-onset oculopharyngeal muscular dystrophy

Courtney E. French, F. Muntoni, M. Tarnopolsky, 2022, Nature Communications.

Beyond aggregation: Pathological phase transitions in neurodegenerative disease

R. Pappu, J. Taylor, Cécile Mathieu, 2020, Science.

Bridging biophysics and neurology: aberrant phase transitions in neurodegenerative disease

J. Taylor, Natalia B. Nedelsky, J. Taylor, 2019, Nature Reviews Neurology.

Linking hnRNP Function to ALS and FTD Pathology

J. Taylor, M. Purice, J. Taylor, 2018, Front. Neurosci..

Nuclear-Import Receptors Reverse Aberrant Phase Transitions of RNA-Binding Proteins with Prion-like Domains

Julie C. Sung, O. King, A. Gitler, 2018, Cell.

Effects of Mutations on the Aggregation Propensity of the Human Prion-Like Protein hnRNPA2B1

J. Taylor, S. Cascarina, E. Ross, 2017, Molecular and Cellular Biology.

Protein-RNA Networks Regulated by Normal and ALS-Associated Mutant HNRNPA2B1 in the Nervous System

Christopher B. Burge, Steven Finkbeiner, Gene W. Yeo, 2016, Neuron.

Protein-RNA Networks Re gulated by Normal and ALS-Associated Mutant HNRNPA 2 B 1 in the Nervous System Highlights

Gene W. Yeo, M. Ares, C. Burge, 2016 .

TDP-43 suppresses CGG repeat-induced neurotoxicity through interactions with HnRNP A2/B1.

Brian D. Freibaum, J. Taylor, P. Todd, 2014, Human molecular genetics.

Exome Sequencing Reveals VCP Mutations as a Cause of Familial ALS

Patrizia Sola, Joanne Wuu, Michael Benatar, 2011, Neuron.

Flightless flies: Drosophila models of neuromuscular disease

J. Taylor, T. Lloyd, J. Taylor, 2010, Annals of the New York Academy of Sciences.

Neurotoxic microglia promote TDP-43 proteinopathy in progranulin deficiency

Michelle K. Cahill, Kevin W. Kelley, A. Kriegstein, 2020, Nature.

TDP-43 and RNA form amyloid-like myo-granules in regenerating muscle

Aaron M. Johnson, D. Eisenberg, R. Parker, 2018, Nature.

Regulatory Role of RNA Chaperone TDP-43 for RNA Misfolding and Repeat-Associated Translation in SCA31

J. Taylor, K. Wada, C. E. Pearson, 2017, Neuron.

Ubiquitination is essential for recovery of cellular activities after heat shock

Brian A. Maxwell, J. Taylor, Junmin Peng, 2021, Science.

GGGGCC repeat expansion in C9orf72 compromises nucleocytoplasmic transport

Bruce L. Miller, Leonard Petrucelli, L. Petrucelli, 2015, Nature.

Transcription of Human Immunodeficiency Virus Promoter in CNS-Derived Cells: Effect of TAT on Expression of Viral and Cellular Genes

J. Taylor, K. Khalili, S. Amini, 1995 .

Evidence that a sequence similar to TAR is important for induction of the JC virus late promoter by human immunodeficiency virus type 1 Tat

J. Taylor, K. Khalili, J. Rappaport, 1992, Journal of virology.

The tumor suppressor protein p53 strongly alters human immunodeficiency virus type 1 replication

J. Taylor, K. Khalili, R. Pomerantz, 1994, Journal of virology.

TAR-independent replication of human immunodeficiency virus type 1 in glial cells

O. Bagasra, J. Taylor, K. Khalili, 1992, Journal of virology.

Central nervous system-derived cells express a kappa B-binding activity that enhances human immunodeficiency virus type 1 transcription in vitro and facilitates TAR-independent transactivation by Tat

F. Kashanchi, J. Taylor, J. Brady, 1994, Journal of virology.

Activation of HIV-1 transcription by Tat in cells derived from the CNS: evidence for the participation of NF-kappa B--a review.

J. Taylor, K. Khalili, J. Taylor, 1994, Advances in neuroimmunology.

Ubiquitin Modulates Liquid-Liquid Phase Separation of UBQLN2 via Disruption of Multivalent Interactions.

J. Taylor, C. Castañeda, H. Hehnly, 2018, Molecular cell.

A comparative analysis of leucine-rich repeat kinase 2 (Lrrk2) expression in mouse brain and Lewy body disease

David I. Bass, M. Farrer, S. Lincoln, 2007, Neuroscience.

TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics

M. Mesulam, L. Petrucelli, R. Petersen, 2017, Neuron.

CGG Repeat-Associated Translation Mediates Neurodegeneration in Fragile X Tremor Ataxia Syndrome

Peter K. Todd, Ryan E. Mills, R. Mills, 2013, Neuron.

Tau protein liquid–liquid phase separation can initiate tau aggregation

Daniel J. Muller, Anthony A Hyman, A. Hyman, 2018, The EMBO journal.

Phase Separation by Low Complexity Domains Promotes Stress Granule Assembly and Drives Pathological Fibrillization

A. Kanagaraj, J. Taylor, Jihun Lee, 2015, Cell.

Valproic acid increases SMN levels in spinal muscular atrophy patient cells

K. Fischbeck, B. Hill, J. Taylor, 2003, Annals of neurology.

Cancer-associated DDX3X mutations drive stress granule assembly and impair global translation

Michael C. Rusch, A. Kanagaraj, J. Taylor, 2016, Scientific Reports.

A murine model of hnRNPH2-related neurodevelopmental disorder recapitulates clinical features of human disease and reveals a mechanism for genetic compensation of HNRNPH2

Stanislav S Zakharenko, J. Taylor, Y. Chook, 2023, bioRxiv.

TDP-43 and PINK1 mediate CHCHD10S59L mutation–induced defects in Drosophila and in vitro

G. Dorn, J. Taylor, S. Bannwarth, 2021, Nature Communications.

The Role of Dipeptide Repeats in C9ORF72-Related ALS-FTD

Brian D. Freibaum, J. Taylor, A. Poletti, 2017, Front. Mol. Neurosci..

RAN translation at CGG repeats induces ubiquitin proteasome system impairment in models of fragile X-associated tremor ataxia syndrome.

H. Paulson, J. Taylor, P. Todd, 2015, Human molecular genetics.

Protein Arginine Methyltransferase 6 Enhances Polyglutamine-Expanded Androgen Receptor Function and Toxicity in Spinal and Bulbar Muscular Atrophy

F. Sambataro, Nisha M. Badders, J. Taylor, 2015, Neuron.

Valosin-containing protein and the pathogenesis of frontotemporal dementia associated with inclusion body myopathy

J. Taylor, M. Forman, G. P. Ritson, 2007, Acta Neuropathologica.

TIA1 variant drives myodegeneration in multisystem proteinopathy with SQSTM1 mutations

J. Taylor, H. Goebel, P. Chinnery, 2018, The Journal of clinical investigation.

Native Functions of the Androgen Receptor Are Essential to Pathogenesis in a Drosophila Model of Spinobulbar Muscular Atrophy

Rebecca B. Smith, J. Taylor, M. Pennuto, 2010, Neuron.

Characterization of the role of a Class III Pi 3-kinase complex in induction of autophagy

J. Taylor, E. Baehrecke, O. Schuldiner, 2006 .

Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis

Lorne Zinman, Adriano Chiò, Richard W. Orrell, 2014, Nature Neuroscience.

Eukaryotic Stress Granules Are Cleared by Autophagy and Cdc48/VCP Function

R. Parker, J. Taylor, J. Buchan, 2013, Cell.

B2 attenuates polyglutamine‐expanded androgen receptor toxicity in cell and fly models of spinal and bulbar muscular atrophy

K. Fischbeck, J. Taylor, M. Pennuto, 2010, Journal of neuroscience research.

HDAC6 at the Intersection of Autophagy, the Ubiquitin-proteasome System, and Neurodegeneration

J. Taylor, E. Baehrecke, U. Pandey, 2007, Autophagy.

Motor neuron disease-associated loss of nuclear TDP-43 is linked to DNA double-strand break repair defects

J. Taylor, Nicole F. Liachko, B. Kraemer, 2019, Proceedings of the National Academy of Sciences.

Impairments to the lateral geniculate nucleus in Alzheimer ’ s disease but not dementia with Lewy bodies

I. McKeith, A. Khundakar, D. Erskine, 2018 .

Aberrant histone acetylation, altered transcription, and retinal degeneration in a Drosophila model of polyglutamine disease are rescued by CREB-binding protein.

K. Fischbeck, J. Taylor, A. Taye, 2003, Genes & development.

Altered acetylation in polyglutamine disease: an opportunity for therapeutic intervention?

K. Fischbeck, J. Taylor, J. Taylor, 2002, Trends in molecular medicine.

Lost in Transportation: Nucleocytoplasmic Transport Defects in ALS and Other Neurodegenerative Diseases

J. Taylor, Hong-Joo Kim, J. Taylor, 2017, Neuron.

Targeting protein homeostasis in sporadic inclusion body myositis

B. Kalmar, L. Greensmith, J. Taylor, 2016, Science Translational Medicine.

CHAPTER 37 – Drosophila Models of Polyglutamine Disorders

J. Taylor, G. Jackson, Tzu-Kang Sang, 2006 .

Histone Deacetylases Suppress CGG Repeat–Induced Neurodegeneration Via Transcriptional Silencing in Models of Fragile X Tremor Ataxia Syndrome

Peter K. Todd, H. Paulson, J. Taylor, 2010, PLoS genetics.

Selective Modulation of the Androgen Receptor Activation Function-2 Domain Rescues Degeneration in Spinal Bulbar Muscular Atrophy

Albert R La Spada, Yimei Li, Rebecca B. Smith, 2018, Nature Medicine.

Hemolytic anemia presenting as idiopathic intracranial hypertension.

S. Galetta, J. Taylor, N. Volpe, 2002, Neurology.

Therapeutic reduction of ataxin 2 extends lifespan and reduces pathology in TDP-43 mice

David A. Knowles, S. Pulst, Gregor Bieri, 2017, Nature.

Disease mutations in the prion-like domains of hnRNPA1 and hnRNPA2/B1 introduce potent steric zippers that drive excess RNP granule assembly

J. Taylor, J. Shorter, J. Taylor, 2013, Rare diseases.

Selective Accumulation of Aggregation-Prone Proteasome Substrates in Response to Proteotoxic Stress

J. Taylor, N. Dantuma, F. Salomons, 2009, Molecular and Cellular Biology.

Visual Hallucinations in PD and Lewy Body Dementias: Old and New Hypotheses

John-Paul Taylor, M. Onofrj, A. Thomas, 2013, Behavioural neurology.

Fragile X protein mitigates TDP-43 toxicity by remodeling RNA granules and restoring translation.

Daniela C. Zarnescu, D. Zarnescu, A. Gitler, 2015, Human molecular genetics.

TIA 1 variant drives myodegeneration in multisystem proteinopathy with SQSTM 1 mutations

J. Taylor, H. Goebel, P. Chinnery, 2018 .

C9orf72 Poly(PR) Dipeptide Repeats Disturb Biomolecular Phase Separation and Disrupt Nucleolar Function.

Christopher B. Stanley, Diana M. Mitrea, J. Taylor, 2019, Molecular cell.

Profilin 1 Associates with Stress Granules and ALS-Linked Mutations Alter Stress Granule Dynamics

Gregor Bieri, A. Gitler, J. Taylor, 2014, The Journal of Neuroscience.

Ascertainment bias in dementias: a secondary to tertiary centre analysis in Central Italy and conceptual review

John-Paul Taylor, M. Onofrj, A. Thomas, 2013, Aging Clinical and Experimental Research.

Huntingtin Fragments and SOD1 Mutants Form Soluble Oligomers in the Cell

J. Taylor, E. Eisenberg, L. Greene, 2012, PloS one.

Valosin-containing protein (VCP) mutations in sporadic amyotrophic lateral sclerosis

Sonja W. Scholz, Janel O. Johnson, A. Chiò, 2012, Neurobiology of Aging.

MFN1 deacetylation activates adaptive mitochondrial fusion and protects metabolically challenged mitochondria

Sujin Choi, J. Taylor, Joo-Yong Lee, 2014, Journal of Cell Science.

Mutational analysis of the VCP gene in Parkinson's disease

A. Singleton, A. Chiò, B. Traynor, 2012, Neurobiology of Aging.

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

Ruth E. Thomas, L. Pallanck, Rebecca B. Smith, 2013, Neuron.

Deficiency of ATP13A2 Leads to Lysosomal Dysfunction, α-Synuclein Accumulation, and Neurotoxicity

D. Krainc, J. Taylor, E. Tresse, 2012, The Journal of Neuroscience.

Dynein light chain 1 is required for autophagy, protein clearance, and cell death in Drosophila

J. Taylor, E. Baehrecke, U. Pandey, 2009, Proceedings of the National Academy of Sciences.

A small-molecule Nrf1 and Nrf2 activator mitigates polyglutamine toxicity in spinal and bulbar muscular atrophy.

K. Fischbeck, G. Sobue, Nisha M. Badders, 2016, Human molecular genetics.

MAP4K3 inhibits Sirtuin-1 to repress the LKB1–AMPK pathway to promote amino acid-dependent activation of the mTORC1 complex

T. Hunter, B. Winborn, J. Taylor, 2021, Life Science Alliance.

VCP Is Essential for Mitochondrial Quality Control by PINK1/Parkin and this Function Is Impaired by VCP Mutations

Ruth E. Thomas, L. Pallanck, Rebecca B. Smith, 2013, Neuron.

Improved reproducibility of magnetic stimulation-evoked motor potentials in the human masseter by a new method for locating stimulation sites on the scalp.

J. Taylor, D. Walshaw, C. Watson, 1998, Archives of oral biology.

Sarcoplasmic redistribution of nuclear TDP‐43 in inclusion body myositis

Steven A Greenberg, Anthony A Amato, S. Greenberg, 2009, Muscle & nerve.