Dik‐Lung Ma

发表

A G-quadruplex-based, label-free, switch-on luminescent detection assay for Ag+ ions based on the exonuclease III-mediated digestion of C-Ag+-C DNA.

Modi Wang, Ka-Ho Leung, Sheng Lin, 2014, Journal of materials chemistry. B.

The design and development of covalent protein-protein interaction inhibitors for cancer treatment

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2020, Journal of Hematology & Oncology.

Recent advances in the discovery and development of protein- protein interaction modulators by virtual screening

Modi Wang, Sheng Lin, D. Chan, 2015 .

New perspectives on innovative drug discovery: an overview.

Yi-fan Han, Dik‐Lung Ma, S. Pan, 2010, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

G-quadruplex-selective iridium(III) complex as a novel electrochemiluminescence probe for switch-on assay of double-stranded DNA

Dik‐Lung Ma, Shujie Wu, Songen Wang, 2022, Analytical and Bioanalytical Chemistry.

Discovery of a Natural Product-Like iNOS Inhibitor by Molecular Docking with Potential Neuroprotective Effects In Vivo

Modi Wang, D. Chan, C. Leung, 2014, PloS one.

A one-step strategy for ultra-fast and low-cost mass production of plastic membrane microfluidic chips.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2016, Lab on a chip.

A metal-based inhibitor of tumor necrosis factor-α.

R. Abagyan, D. Chan, C. Leung, 2012, Angewandte Chemie.

G-quadruplexes for luminescent sensing and logic gates

D. Chan, C. Leung, Dik‐Lung Ma, 2013, Nucleic acids research.

Discovery of a Natural Product-Like c-myc G-Quadruplex DNA Groove-Binder by Molecular Docking

D. Chan, C. Leung, Dik‐Lung Ma, 2012, PloS one.

Structure-based discovery of natural-product-like TNF-α inhibitors.

R. Abagyan, D. Chan, C. Leung, 2010, Angewandte Chemie.

New Perspectives on How to Discover Drugs from Herbal Medicines: CAM's Outstanding Contribution to Modern Therapeutics

Dik-Lung Ma, Shu-Feng Zhou, Yi-fan Han, 2013, Evidence-based complementary and alternative medicine : eCAM.

Stabilization of G-quadruplex DNA and down-regulation of oncogene c-myc by quindoline derivatives.

A. Chan, Dik‐Lung Ma, J. Tang, 2007, Journal of medicinal chemistry.

In silico screening of quadruplex-binding ligands.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2012, Methods.

Comprehensive quantitative analysis of Shuang-Huang-Lian oral liquid using UHPLC–Q-TOF-MS and HPLC-ELSD

C. Leung, Dik‐Lung Ma, Zhong-Zhen Zhao, 2014, Journal of Pharmaceutical and Biomedical Analysis.

Luminescent detection of DNA-binding proteins

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2011, Nucleic acids research.

Combination of i-motif and G-quadruplex structures within the same strand: formation and application.

Jean-Louis Mergny, Dik-Lung Ma, Jun Zhou, 2013, Angewandte Chemie.

Luminescence switch-on detection of protein tyrosine kinase-7 using a G-quadruplex-selective probe† †Electronic supplementary information (ESI) available: Compound characterisation and supplementary data. See DOI: 10.1039/c5sc01320h Click here for additional data file.

W. Gao, C. Leung, Dik‐Lung Ma, 2015, Chemical science.

Conjugating a groove-binding motif to an Ir(iii) complex for the enhancement of G-quadruplex probe behavior† †Electronic supplementary information (ESI) available: Compound characterisation and supplementary data. See DOI: 10.1039/c6sc00001k

Modi Wang, C. Leung, Dik‐Lung Ma, 2016, Chemical science.

Luminescence approaches for the rapid detection of disease-related receptor proteins using transition metal-based probes.

C. Leung, Dik‐Lung Ma, Chun Wu, 2020, Journal of materials chemistry. B.

The Development of G-Quadruplex-Based Assays for the Detection of Small Molecules and Toxic Substances.

C. Leung, Dik‐Lung Ma, Chun Wu, 2017, Chemistry, an Asian journal.

A long-lived iridium(iii) chemosensor for the real-time detection of GHB.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Journal of materials chemistry. B.

Real-time detection of oxalyl chloride based on a long-lived iridium(iii) probe.

R. Pei, C. Leung, Dik‐Lung Ma, 2017, Dalton transactions.

A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2017, Biosensors & bioelectronics.

Utilization of G-Quadruplex-Forming Aptamers for the Construction of Luminescence Sensing Platforms.

Dik-Lung Ma, Chung-Hang Leung, C. Leung, 2017, ChemPlusChem.

A G-quadruplex-selective luminescent iridium(III) complex and its application by long lifetime.

C. Leung, Dik‐Lung Ma, Lihua Lu, 2017, Biochimica et biophysica acta. General subjects.

An Aldol Reaction-Based Iridium(III) Chemosensor for the Visualization of Proline in Living Cells

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2016, Scientific Reports.

Interaction of an Iridium(III) Complex with G-Quadruplex DNA and Its Application in Luminescent Switch-On Detection of Siglec-5.

C. Leung, Dik‐Lung Ma, J. Mergny, 2016, Analytical chemistry.

Application of iridium(III) complex in label-free and non-enzymatic electrochemical detection of hydrogen peroxide based on a novel “on-off-on” switch platform

Chao Yang, C. Leung, Dik‐Lung Ma, 2016, Scientific Reports.

An Ir(III) complex chemosensor for the detection of thiols

Dik-Lung Ma, Chung-Hang Leung, C. Leung, 2016, Science and technology of advanced materials.

A luminescent G-quadruplex-selective iridium(iii) complex for the label-free detection of lysozyme.

Jin-jian Lu, Modi Wang, C. Leung, 2016, Journal of materials chemistry. B.

A versatile nanomachine for the sensitive detection of platelet-derived growth factor-BB utilizing a G-quadruplex-selective iridium(III) complex.

C. Leung, Dik‐Lung Ma, Lihua Lu, 2016, Biosensors & bioelectronics.

A Luminescent Cocaine Detection Platform Using a Split G-Quadruplex-Selective Iridium(III) Complex and a Three-Way DNA Junction Architecture.

Chao Yang, Dik-Lung Ma, Chung-Hang Leung, 2015, ACS applied materials & interfaces.

Detection of nicking endonuclease activity using a G-quadruplex-selective luminescent switch-on probe

Lihua Lu, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2014 .

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe† †Electronic supplementary information (ESI) available: Compound characterisation and supplementary data. See DOI: 10.1039/c4sc03319a Click here for additional data file.

Sheng Lin, Dik-Lung Ma, Chung-Hang Leung, 2014, Chemical science.

Dual function luminescent transition metal complexes for cancer theranostics: The combination of diagnosis and therapy

C. Leung, Dik‐Lung Ma, Guodong Li, 2019, Coordination Chemistry Reviews.

Iridium(iii) complexes as reaction based chemosensors for medical diagnostics.

C. Leung, Dik‐Lung Ma, Ke‐Jia Wu, 2018, Dalton transactions.

Luminescent detection of nicking endonuclease Nb.BsmI activity by using a G-quadruplex-selective iridium(III) complex in aqueous solution

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2017 .

Luminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Scientific Reports.

A reaction-based luminescent switch-on sensor for the detection of OH- ions in simulated wastewater.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Dalton transactions.

A luminescence switch-on assay for the detection of specific gene deletion using G-quadruplex DNA and silver nanoclusters

Modi Wang, C. Leung, Dik‐Lung Ma, 2017 .

Discovery of a Drug‐Like G‐Quadruplex Binding Ligand by High‐Throughput Docking

R. Abagyan, Dik‐Lung Ma, Y. Leung, 2008, ChemMedChem.

Group 9 organometallic compounds for therapeutic and bioanalytical applications.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2014, Accounts of chemical research.

A label-free G-quadruplex-based luminescent switch-on assay for the selective detection of histidine.

Modi Wang, D. Chan, C. Leung, 2013, Methods.

A G-quadruplex-selective luminescent switch-on probe for the detection of sub-nanomolar human neutrophil elastase

Hui Yang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2013 .

A parallel G-quadruplex-selective luminescent probe for the detection of nanomolar calcium(II) ion.

Modi Wang, D. Chan, C. Leung, 2013, Methods.

Luminescent and colorimetric strategies for the label-free DNA-based detection of enzyme activity.

D. Chan, C. Leung, Dik‐Lung Ma, 2013, Briefings in functional genomics.

A suspending-droplet mode paper-based microfluidic platform for low-cost, rapid, and convenient detection of lead(II) ions in liquid solution.

Kangning Ren, Chong Hu, Dik-Lung Ma, 2018, Biosensors & bioelectronics.

Structure-Based Approaches Targeting Oncogene Promoter G-Quadruplexes

Ka-Ho Leung, D. Chan, C. Leung, 2013 .

A 7-methoxybicoumarin derivative selectively inhibits BRD4 BD2 for anti-melanoma therapy.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2020, International journal of biological macromolecules.

Luminescent detection of human serum albumin in aqueous solution using a cyclometallated iridium(III) complex

D. Chan, C. Leung, Dik‐Lung Ma, 2014 .

Pharmacophore modeling for the identification of small-molecule inhibitors of TACE.

Ka-Ho Leung, Sheng Lin, D. Chan, 2015, Methods.

Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening.

Modi Wang, Ka-Ho Leung, Sheng Lin, 2015, Methods.

Structure-based identification of a NEDD8-activating enzyme inhibitor via drug repurposing.

C. Leung, Dik‐Lung Ma, H. D. Wang, 2018, European journal of medicinal chemistry.

Oligosaccharide-marker approach for qualitative and quantitative analysis of specific polysaccharide in herb formula by ultra-high-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry: Dendrobium officinale, a case study.

C. Leung, Dik‐Lung Ma, Zhong-Zhen Zhao, 2019, Journal of chromatography. A.

Molecular modeling of drug-DNA interactions: virtual screening to structure-based design.

D. Chan, C. Leung, Dik‐Lung Ma, 2011, Biochimie.

Interfering with S100B-effector protein interactions for cancer therapy.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2020, Drug discovery today.

Mimicking Strategy for Protein–Protein Interaction Inhibitor Discovery by Virtual Screening

C. Leung, Dik‐Lung Ma, Chun Wu, 2019, Molecules.

Application of a DNA-based luminescence switch-on method for the detection of mercury(II) ions in water samples from Hong Kong

Ka-Ho Leung, D. Chan, C. Leung, 2012 .

Structure-based screening and optimization of cytisine derivatives as inhibitors of the menin-MLL interaction.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2016, Chemical communications.

An oligonucleotide-based switch-on luminescent probe for the detection of kanamycin in aqueous solution

Ka-Ho Leung, D. Chan, C. Leung, 2013 .

A natural product-like inhibitor of NEDD8-activating enzyme.

Ruben Abagyan, Hui Yang, Dik-Lung Ma, 2011, Chemical communications.

A Rhodium(III) Complex as an Inhibitor of Neural Precursor Cell Expressed, Developmentally Down-Regulated 8-Activating Enzyme with in Vivo Activity against Inflammatory Bowel Disease.

C. Leung, Dik‐Lung Ma, Yuqiang Wang, 2017, Journal of medicinal chemistry.

Rhodium complexes as therapeutic agents.

Chao Yang, Modi Wang, C. Leung, 2016, Dalton transactions.

Structure-based discovery of an immunomodulatory inhibitor of TLR1-TLR2 heterodimerization from a natural product-like database.

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Chemical communications.

In silico identification of natural product inhibitors of JAK2.

D. Chan, C. Leung, Dik‐Lung Ma, 2015, Methods.

Discovery of deoxyvasicinone derivatives as inhibitors of NEDD8-activating enzyme.

Ka-Ho Leung, Sheng Lin, D. Chan, 2015, Methods.

A Metal-Based Inhibitor of NEDD8-Activating Enzyme

D. Chan, C. Leung, Dik‐Lung Ma, 2012, PloS one.

2-Methoxy-6-acetyl-7-methyljuglone (MAM), a natural naphthoquinone, induces NO-dependent apoptosis and necroptosis by H2O2-dependent JNK activation in cancer cells.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Free radical biology & medicine.

Low toxic fluorescent nanoprobe applicable for sensing pH changes in biological environment

C. Leung, Dik‐Lung Ma, Li-Juan Liu, 2018 .

Structure Characterization and Immunomodulating Effects of Polysaccharides Isolated from Dendrobium officinale.

C. Leung, Dik‐Lung Ma, S. Nie, 2016, Journal of agricultural and food chemistry.

Inhibition of TLR1/2 dimerization by enantiomers of metal complexes.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2016, Chemical communications.

Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: luminescent probe and down-regulation of c-myc oncogene expression.

R. Abagyan, C. Leung, Dik‐Lung Ma, 2009, Chemistry.

Emerging Screening Approaches in the Development of Nrf2–Keap1 Protein–Protein Interaction Inhibitors

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2019, International journal of molecular sciences.

Biological Applications of Supramolecular Coordination Complexes

Ka-Ho Leung, C. Leung, Dik‐Lung Ma, 2017 .

Identification of an Iridium(III)-Based Inhibitor of Tumor Necrosis Factor-α.

Modi Wang, C. Leung, Dik‐Lung Ma, 2016, Journal of medicinal chemistry.

Metal complexes as potential modulators of inflammatory and autoimmune responses

Sheng Lin, C. Leung, Dik‐Lung Ma, 2014, Chemical science.

Detection of 3'→5' exonuclease activity using a metal-based luminescent switch-on probe.

Modi Wang, D. Chan, C. Leung, 2013, Methods.

A tumour microenvironment-responsive polymeric complex for targeted depletion of tumour-associated macrophages (TAMs).

C. Leung, Dik‐Lung Ma, Lei Dong, 2017, Journal of materials chemistry. B.

Future Frontiers in Diversity-Oriented Synthesis

C. Leung, Dik‐Lung Ma, 2013 .

Aminoglycosylation Can Enhance the G-Quadruplex Binding Activity of Epigallocatechin

Dik‐Lung Ma, Zhi-Hong Jiang, Li-Ping Bai, 2013, PloS one.

Stable anticancer gold(III)-porphyrin complexes: effects of porphyrin structure.

C. Leung, Dik‐Lung Ma, C. Che, 2010, Chemistry.

Iridium-based probe for luminescent nitric oxide monitoring in live cells

C. Leung, Dik‐Lung Ma, H. D. Wang, 2018, Scientific Reports.

Luminescent G-quadruplex probes.

C. Leung, Dik‐Lung Ma, Hui Yang, 2012, Current pharmaceutical design.

Glycyrrhetinic acid induces cytoprotective autophagy via the inositol-requiring enzyme 1α-c-Jun N-terminal kinase cascade in non-small cell lung cancer cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2015, Oncotarget.

Recent Progress and Development of G-Quadruplex-Based Luminescent Assays for Ochratoxin A Detection

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2020, Frontiers in Chemistry.

A dual-functional molecular strategy for in situ suppressing and visualizing of neuraminidase in aqueous solution using iridium(iii) complexes.

C. Leung, Dik‐Lung Ma, Ke‐Jia Wu, 2019, Chemical communications.

Structure-based design of platinum(II) complexes as c-myc oncogene down-regulators and luminescent probes for G-quadruplex DNA.

C. Leung, Dik‐Lung Ma, C. Che, 2010, Chemistry.

Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA.

Dik‐Lung Ma, C. Che, Siu-cheong Yan, 2009, Journal of the American Chemical Society.

Recent advances in iridium(iii) complex-assisted nanomaterials for biological applications.

C. Leung, Dik‐Lung Ma, Chun Wu, 2018, Journal of materials chemistry. B.

Synthesis and Electronic Spectroscopy of Luminescent Cyclometalated Platinum−Anthracenyl Complexes

Dik‐Lung Ma, J. Vittal, Kwok‐yin Wong, 2007 .

Monitoring of DNA-protein interaction with single gold nanoparticles by localized scattering plasmon resonance spectroscopy.

Dik‐Lung Ma, Hung-Wing Li, Ho-Man Chan, 2013, Methods.

Structure-Based Discovery of a Selective KDM5A Inhibitor that Exhibits Anti-Cancer Activity via Inducing Cell Cycle Arrest and Senescence in Breast Cancer Cell Lines

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2019, Cancers.

G-quadruplex DNA for the construction of sensing platforms

Modi Wang, D. Chan, C. Leung, 2015 .

Luminescent oligonucleotide-based detection of enzymes involved with DNA repair

D. Chan, C. Leung, Dik‐Lung Ma, 2013 .

A long-lifetime iridium(iii) complex for lysosome tracking with high specificity and a large Stokes shift.

Chao Yang, C. Leung, Dik‐Lung Ma, 2018, Journal of materials chemistry. B.

Inhibition of the Ras/Raf interaction and repression of renal cancer xenografts in vivo by an enantiomeric iridium(iii) metal-based compound† †Electronic supplementary information (ESI) available: Synthetic methods, characterization, and biological assays details. See DOI: 10.1039/c7sc00311k Click h

Sheng Lin, C. Leung, Dik‐Lung Ma, 2017, Chemical science.

Label-free luminescent detection of LMP1 gene deletion using an intermolecular G-quadruplex-based switch-on probe.

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Biosensors & bioelectronics.

UGT73F17, a new glycosyltransferase from Glycyrrhiza uralensis, catalyzes the regiospecific glycosylation of pentacyclic triterpenoids.

C. Leung, Dik‐Lung Ma, Wei Song, 2018, Chemical communications.

Small Molecule Pin1 Inhibitor Blocking NF-κB Signaling in Prostate Cancer Cells.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2018, Chemistry, an Asian journal.

Luteolin exerted less inhibitory effect on macrophage activation induced by Astragalus polysaccharide than by lipopolysaccharide

C. Leung, Dik‐Lung Ma, Z. Bian, 2017 .

Metalated Chromene and Chromone Complexes: pH Switchable Metal-Carbon Bonding Interaction, Photo-triggerable Chromone Delivery Application, and Antioxidative Activity.

C. Leung, Dik‐Lung Ma, Lai‐Hon Chung, 2018, Chemistry.

An oligonucleotide-based label-free luminescent switch-on probe for RNA detection utilizing a G-quadruplex-selective iridium(III) complex.

Ka-Ho Leung, D. Chan, C. Leung, 2014, Nanoscale.

A cyclometallated iridium(III) complex as a c-myc G-quadruplex stabilizer and down-regulator of c-myc oncogene expression.

D. Chan, C. Leung, Dik‐Lung Ma, 2013, Current medicinal chemistry.

Rebalancing metal dyshomeostasis for Alzheimer’s disease therapy

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2019, JBIC Journal of Biological Inorganic Chemistry.

Akt downstream of NFκB, MAPKs and IRF3 pathway involved in macrophage activation induced by Astragalus polysaccharide RAP

C. Leung, Dik‐Lung Ma, Z. Bian, 2017 .

A long-lived ferrocene-conjugated iridium(III) complex for sensitive turn-on luminescence detection of traces of DMSO in water and human serum.

C. Leung, Dik‐Lung Ma, Chun Wu, 2017, Analytica chimica acta.

Recent advances in the managements of type 2 diabetes mellitus and natural hypoglycemic substances

C. Leung, Dik‐Lung Ma, Chong Ning, 2022, Food Science and Human Wellness.

A simple iridium(III) dimer as a switch-on luminescent chemosensor for carbon disulfide detection in water samples.

C. Leung, Dik‐Lung Ma, Chun Wu, 2019, Analytica chimica acta.

Using two-phase solvent systems for sample pretreatment increases yield of counter-current chromatography: Anemarrhena asphodeloides saponins, a case study

C. Leung, Dik‐Lung Ma, Z. Bian, 2014 .

Switching on the Phosphorescence of Pyrene by Cycloplatination

Dik‐Lung Ma, Kwok‐yin Wong, W. Chung, 2009 .

An iridium(III) complex/G-quadruplex ensemble for detection of ochratoxin A based on long-lifetime luminescent.

R. Pei, C. Leung, Dik‐Lung Ma, 2019, Analytical biochemistry.

Specific blocking of CREB/DNA binding by cyclometalated platinum(II) complexes.

C. Leung, Dik‐Lung Ma, C. Che, 2011, Angewandte Chemie.

Application of metal–organic framework for the adsorption and detection of food contamination

C. Leung, Dik‐Lung Ma, Min Fang, 2021 .

A dicationic organoplatinum(II) complex containing a bridging 2,5-bis-(4-ethynylphenyl)-[1,3,4]oxadiazole ligand behaves as a phosphorescent gelator for organic solvents.

Dik‐Lung Ma, C. Che, S. Chui, 2008, Chemistry, an Asian journal.

Cell-derived artificial nanovesicle as a drug delivery system for malignant melanoma treatment.

C. Leung, Dik‐Lung Ma, Ying Lin, 2022, Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie.

Aurone derivatives as Vps34 inhibitors that modulate autophagy

C. Leung, Dik‐Lung Ma, J. Wan, 2019, Acta pharmaceutica Sinica. B.

A long lifetime iridium(III) complex as a sensitive luminescent probe for bisulfite detection in living zebrafish

C. Leung, Dik‐Lung Ma, Chao Yang, 2017 .

SURVEY AND SUMMARY Luminescent detection of DNA-binding proteins

D. Chan, C. Leung, Dik‐Lung Ma, 2012 .

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo.

D. Chan, C. Leung, Dik‐Lung Ma, 2014, Journal of inorganic biochemistry.

Carrageenan activates monocytes via type-specific binding with interleukin-8: an implication for design of immuno-active biomaterials.

C. Leung, Dik‐Lung Ma, Lei Dong, 2017, Biomaterials science.

A highly selective luminescent switch-on probe for histidine/histidine-rich proteins and its application in protein staining.

Dik‐Lung Ma, Y. Leung, Wing‐Leung Wong, 2008, Angewandte Chemie.

Cyclometalated platinum(II) complexes as highly sensitive luminescent switch-on probes for practical application in protein staining and cell imaging.

Dik‐Lung Ma, C. Che, K. Ng, 2009, Chemistry.

Anticancer osmium complex inhibitors of the HIF-1α and p300 protein-protein interaction

Chao Yang, C. Leung, Dik‐Lung Ma, 2017, Scientific Reports.

Discovery of a tetrahydroisoquinoline-based CDK9-cyclin T1 protein–protein interaction inhibitor as an anti-proliferative and anti-migration agent against triple-negative breast cancer cells

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2021, Genes & diseases.

Inhibition of the CDK9–cyclin T1 protein–protein interaction as a new approach against triple-negative breast cancer

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2021, Acta pharmaceutica Sinica. B.

Interference of Quercetin on Astragalus Polysaccharide-Induced Macrophage Activation

C. Leung, Dik‐Lung Ma, Z. Bian, 2018, Molecules.

Ratiometric fluorescent detection of pesticide based on split aptamer and magnetic separation

C. Leung, Dik‐Lung Ma, Lihua Lu, 2022, Sensors and Actuators B: Chemical.

Identification of an iridium(III) complex with anti-bacterial and anti-cancer activity

Jin-jian Lu, Modi Wang, C. Leung, 2015, Scientific Reports.

Chemical Structure and Immunomodulating Activities of an α-Glucan Purified from Lobelia chinensis Lour

C. Leung, Dik‐Lung Ma, Ge Zhang, 2016, Molecules.

Fluorophore-labeled beta-lactamase as a biosensor for beta-lactam antibiotics: a study of the biosensing process.

Dik‐Lung Ma, Yanxiang Zhao, Y. Leung, 2008, Journal of the American Chemical Society.

An oligosaccharide-marker approach to quantify specific polysaccharides in herbal formula by LC-qTOF-MS: Danggui Buxue Tang, a case study.

C. Leung, Dik‐Lung Ma, Ge Zhang, 2020, Journal of pharmaceutical and biomedical analysis.

Bis-intercalative dinuclear platinum(II) 6-phenyl-2,2′-bipyridine complexes exhibit enhanced DNA affinity but similar cytotoxicity compared to the mononuclear unit

Dik‐Lung Ma, C. Che, Mengsu Yang, 2003, JBIC Journal of Biological Inorganic Chemistry.

Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform

Chao Yang, C. Leung, Dik‐Lung Ma, 2017, Scientific Reports.

G-quadruplex-selective iridium(III) complex as a novel electrochemiluminescence probe for switch-on assay of double-stranded DNA

Dik‐Lung Ma, Shujie Wu, Songen Wang, 2022, Analytical and Bioanalytical Chemistry.

Luminescent Ruthenium(II) Complex Bearing Bipyridine and N-Heterocyclic Carbene-based C∧N∧C Pincer Ligand for Live-Cell Imaging of Endocytosis

Dik-Lung Ma, Chung-Hang Leung, Sung-Kay Chiu, 2015, Scientific Reports.

Silencing Stem Cell Factor Gene in Fibroblasts to Regulate Paracrine Factor Productions and Enhance c-Kit Expression in Melanocytes on Melanogenesis

C. Leung, Dik‐Lung Ma, Cheng-Chung Chang, 2018, International journal of molecular sciences.

Brønsted Base-Mediated Aziridination of 2-Alkyl-Substituted-1,3-Dicarbonyl Compounds and 2-Acyl-Substituted-1,4-Dicarbonyl Compounds by Iminoiodanes

C. Leung, Dik‐Lung Ma, P. Chan, 2017 .

Construction of a Nano Biosensor for Cyanide Anion Detection and Its Application in Environmental and Biological Systems.

C. Leung, Dik‐Lung Ma, Chao Yang, 2017, ACS sensors.

Gold-Catalyzed Cycloisomerization and Diels-Alder Reaction of 1,4,9-Dienyne Esters to 3 a,6-Methanoisoindole Esters with Pro-Inflammatory Cytokine Antagonist Activity.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2015, Chemistry.

G-quadruplex-based detection of glyphosate in complex biological systems by a time-resolved luminescent assay

C. Leung, Dik‐Lung Ma, Hao Liu, 2020 .

Characterization of His-tagged Rat Uroporphyrinogen III Synthase Wild-Type and Variant Enzymes

Dik‐Lung Ma, Xiusheng Chu, Xiaojun Liu, 2007, The protein journal.

Luminescent Iridium(III) Chemosensor for Tandem Detection of F– and Al3+

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2017, ACS omega.

Iminoiodane- and Brønsted Base-Mediated Cross Dehydrogenative Coupling of Cyclic Ethers with 1,3-Dicarbonyl Compounds

C. Leung, Dik‐Lung Ma, P. Chan, 2015, Molecules.

Synthesis and Evaluation of Dibenzothiophene Analogues as Pin1 Inhibitors for Cervical Cancer Therapy

C. Leung, Dik‐Lung Ma, Yuyang Zhou, 2019, ACS omega.

Drug screening strategies using metal-based luminescent probes

C. Leung, Dik‐Lung Ma, Chun Wu, 2021, TrAC Trends in Analytical Chemistry.

A robust photoluminescence screening assay identifies uracil-DNA glycosylase inhibitors against prostate cancer†

C. Leung, Dik‐Lung Ma, Chun Wu, 2020, Chemical science.

Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex.

Ka-Ho Leung, D. Chan, C. Leung, 2013, ACS applied materials & interfaces.

Detection of base excision repair enzyme activity using a luminescent G-quadruplex selective switch-on probe.

Ka-Ho Leung, D. Chan, C. Leung, 2013, Chemical communications.

Silver Triflate Catalyzed Cyclopropyl Carbinol Rearrangement for Benzo[b]oxepine and 2H‐Chromene Synthesis

C. Leung, Dik‐Lung Ma, P. Chan, 2015 .

Cell imaging of dopamine receptor using agonist labeling iridium(iii) complex† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c7sc04798c

W. Tan, C. Leung, Dik‐Lung Ma, 2017, Chemical science.

Aliphatic Group-Tethered Iridium Complex as a Theranostic Agent against Malignant Melanoma Metastasis

C. Leung, Dik‐Lung Ma, H. D. Wang, 2020 .

Metal-indolizine zwitterion complexes as a new class of organometallic material: A spectroscopic and theoretical investigation

C. Leung, Dik‐Lung Ma, Lai‐Hon Chung, 2014 .

DNA‐Binding Small Molecules as Inhibitors of Transcription Factors

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013, Medicinal research reviews.

Development of a NIR iridium(III) complex for self-calibrated and luminogenic detection of boron trifluoride.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2022, Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy.

Some uses of transition metal complexes as anti-cancer and anti-HIV agents.

Dik-Lung Ma, Chi-Ming Che, Dik‐Lung Ma, 2007, Dalton transactions.

Iridium(III)-based chemosensors for the detection of metal ions.

C. Leung, Dik‐Lung Ma, Q. Han, 2019, Methods.

Recent advances in luminescent heavy metal complexes for sensing

Ka-Ho Leung, D. Chan, C. Leung, 2012 .

Discovery of a natural product inhibitor targeting protein neddylation by structure-based virtual screening.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2012, Biochimie.

Cyclometalated gold(III) complexes with N-heterocyclic carbene ligands as topoisomerase I poisons.

C. Leung, Dik‐Lung Ma, C. Che, 2010, Chemical communications.

Bioactive luminescent transition-metal complexes for biomedical applications.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013, Angewandte Chemie.

Iridium(III) Complexes Targeting Apoptotic Cell Death in Cancer Cells

C. Leung, Dik‐Lung Ma, Chun Wu, 2019, Molecules.

Bioactive iridium and rhodium complexes as therapeutic agents

D. Chan, C. Leung, Dik‐Lung Ma, 2013 .

A bioactive ligand-conjugated iridium(III) metal-based complex as a Keap1–Nrf2 protein-protein interaction inhibitor against acetaminophen-induced acute liver injury

C. Leung, Dik‐Lung Ma, J. Wan, 2021, Redox biology.

Epigenetic modulation by inorganic metal complexes

Ka-Ho Leung, C. Leung, Dik‐Lung Ma, 2016 .

Label-free luminescent oligonucleotide-based probes.

Ka-Ho Leung, D. Chan, C. Leung, 2013, Chemical Society reviews.

A luminescent G-quadruplex switch-on probe for the highly selective and tunable detection of cysteine and glutathione.

Ka-Ho Leung, D. Chan, C. Leung, 2013, Chemical communications.

Recent development of transition metal complexes with in vivo antitumor activity.

C. Leung, Dik‐Lung Ma, Jiaxin Liang, 2017, Journal of inorganic biochemistry.

Synthesis of highly substituted indene derivatives by Brønsted acid catalyzed Friedel–Crafts reaction of homoallylic alcohols

C. Leung, Dik‐Lung Ma, Weidong Rao, 2014 .

Peptide-conjugated long-lived theranostic imaging toolbox for targeting GRPr in cancer and immune cells.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2020, Angewandte Chemie.

A Colorimetric and Luminescent Dual-Modal Assay for Cu(II) Ion Detection Using an Iridium(III) Complex

D. Chan, C. Leung, Dik‐Lung Ma, 2014, PLoS ONE.

A selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar silver(I) ions in aqueous solution.

D. Chan, C. Leung, Dik‐Lung Ma, 2010, Chemical communications.

Oligonucleotide-based luminescent detection of metal ions.

D. Chan, C. Leung, Dik‐Lung Ma, 2011, Chemistry, an Asian journal.

A long-lived peptide-conjugated iridium(iii) complex as a luminescent probe and inhibitor of the cell migration mediator, formyl peptide receptor 2† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c8sc02733a

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2018, Chemical science.

Antagonizing STAT5B dimerization with an osmium complex

C. Leung, Dik‐Lung Ma, Jiaxin Liang, 2016, Scientific Reports.

A dual-functional luminescent probe for imaging H2S in living zebrafish and discrimination hypoxic cells from normoxic cells

Chao Yang, C. Leung, Dik‐Lung Ma, 2018 .

Phosphorescent Imaging of Living Cells Using a Cyclometalated Iridium(III) Complex

D. Chan, C. Leung, Dik‐Lung Ma, 2013, PloS one.

Luminescent cyclometalated platinum(II) complexes with amino acid ligands for protein binding.

Dik‐Lung Ma, C. Che, Phyllis Kit-Man Siu, 2005, Chemical communications.

A gold(III) porphyrin complex with antitumor properties targets the Wnt/beta-catenin pathway.

Ruben Abagyan, Dik-Lung Ma, Yu Wang, 2010, Cancer research.

A bifunctional platinum(II) complex capable of intercalation and hydrogen-bonding interactions with DNA: binding studies and cytotoxicity.

Dik‐Lung Ma, C. Che, 2003, Chemistry.

A label-free G-quadruplex-based switch-on fluorescence assay for the selective detection of ATP.

Hui Yang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2012, The Analyst.

Luminescent chemosensors by using cyclometalated iridium(iii) complexes and their applications

Sheng Lin, C. Leung, Dik‐Lung Ma, 2016, Chemical science.

Visualization of Zn²⁺ ions in live zebrafish using a luminescent iridium(III) chemosensor.

D. Chan, C. Leung, Dik‐Lung Ma, 2014, ACS applied materials & interfaces.

A labile iridium(III) complex-based luminogenic probe for the ratiometric detection of dithiocarbamate compounds in living system

C. Leung, Dik‐Lung Ma, J. Wang, 2022, Sensors and Actuators B: Chemical.

Structure-based optimization of FDA-approved drug methylene blue as a c-myc G-quadruplex DNA stabilizer.

Hui Yang, Zhi-Hong Jiang, Dik-Lung Ma, 2011, Biochimie.

Silver nanoclusters functionalized with Ce(III) ions are a viable “turn-on-off” fluorescent probe for sulfide

C. Leung, Dik‐Lung Ma, Jinshui Liu, 2018, Microchimica Acta.

A long lifetime luminescent iridium(III) complex chemosensor for the selective switch-on detection of Al(3+) ions.

Modi Wang, C. Leung, Dik‐Lung Ma, 2016, Chemical communications.

Organoplatinum(II) complexes with nucleobase motifs as inhibitors of human topoisomerase II catalytic activity.

C. Leung, Dik‐Lung Ma, C. Che, 2010, Chemistry, an Asian journal.

A G-pentaplex-based assay for Cs(+) ions in aqueous solution using a luminescent Ir(III) complex.

C. Leung, Dik‐Lung Ma, Yitao Wang, 2016, Biosensors & bioelectronics.

Recent Developments in G-Quadruplex Probes.

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Chemistry & biology.

Development of a Long-Lived Luminescence Probe for Visualizing β-Galactosidase in Ovarian Carcinoma Cells.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2017, Analytical chemistry.

An anti-prostate cancer benzofuran-conjugated iridium(III) complex as a dual inhibitor of STAT3 and NF-κB.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2017, Cancer letters.

Synthesis and Biological Activity of a Platinum(II) 6‐Phenyl‐2,2′‐bipyridine Complex and Its Dimeric Analogue

Dik‐Lung Ma, C. Che, Mengsu Yang, 2003, Chembiochem : a European journal of chemical biology.

DNA binding and cytotoxicity of ruthenium(II) and rhenium(I) complexes of 2-amino-4-phenylamino-6-(2-pyridyl)-1,3,5-triazine.

Dik‐Lung Ma, F. Siu, C. Che, 2007, Inorganic chemistry.

Biofunctional Activities of Equisetum ramosissimum Extract: Protective Effects against Oxidation, Melanoma, and Melanogenesis

C. Leung, Dik‐Lung Ma, C. Chiu, 2016, Oxidative medicine and cellular longevity.

Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2018, Chemical communications.

Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Anti-Fatigue Effects of the Unique Polysaccharide Marker of Dendrobium officinale on BALB/c Mice

C. Leung, Dik‐Lung Ma, Q. Han, 2017, Molecules.

A small molecule HIF-1α stabilizer that accelerates diabetic wound healing

C. Di Primo, C. Leung, Dik‐Lung Ma, 2021, Nature Communications.

Transition metal complexes as imaging or therapeutic agents for neurodegenerative diseases.

C. Leung, Dik‐Lung Ma, Chun Wu, 2020, Journal of materials chemistry. B.

An iridium(iii)-based irreversible protein–protein interaction inhibitor of BRD4 as a potent anticancer agent† †Electronic supplementary information (ESI) available: Synthetic methods, characterization and biological assays details. See DOI: 10.1039/c5sc02321a Click here for additional data file.

Ka-Ho Leung, C. Leung, Dik‐Lung Ma, 2015, Chemical science.

A metal-based tumour necrosis factor-alpha converting enzyme inhibitor.

C. Leung, Dik‐Lung Ma, Chun‐Yuen Wong, 2015, Chemical communications.

Antagonizing STAT3 dimerization with a rhodium(III) complex.

Ka-Ho Leung, D. Chan, C. Leung, 2014, Angewandte Chemie.

Proteomic and transcriptomic study on the action of a cytotoxic saponin (Polyphyllin D): Induction of endoplasmic reticulum stress and mitochondria‐mediated apoptotic pathways

Mengsu Yang, Dik‐Lung Ma, Qing‐Yu He, 2008, Proteomics.

Transition metal complexes as electrocatalysts : Development and applications in electro-oxidation reactions

Dik‐Lung Ma, Wing‐Leung Wong, Kwong-chak Cheung, 2007 .

TLR-4 may mediate signaling pathways of Astragalus polysaccharide RAP induced cytokine expression of RAW264.7 cells.

C. Leung, Dik‐Lung Ma, K. Fung, 2016, Journal of ethnopharmacology.

Synergistic Effects of Linderanolide B Combined with Arbutin, PTU or Kojic Acid on Tyrosinase Inhibition.

C. Leung, Dik‐Lung Ma, Z. Wen, 2015, Current pharmaceutical biotechnology.

Long-lived iridium(III) complexes as luminescent probes for the detection of periodate in living cells

C. Leung, Dik‐Lung Ma, Chun‐Yuen Wong, 2019, Sensors and Actuators B: Chemical.

Molecular docking for virtual screening of natural product databases

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2011 .

Water soluble luminescent platinum terpyridine complexes with glycosylated acetylide and arylacetylide ligands: photoluminescent properties and cytotoxicities.

Dik‐Lung Ma, C. Che, Mengsu Yang, 2005, Chemical communications.

A novel dinuclear iridium(III) complex as a G-quadruplex-selective probe for the luminescent switch-on detection of transcription factor HIF-1α

Jin-jian Lu, Modi Wang, C. Leung, 2016, Scientific Reports.

Luminescence switch-on assay of interferon-gamma using a G-quadruplex-selective iridium(III) complex.

C. Leung, Dik‐Lung Ma, J. Mergny, 2015, Chemical communications.

Label-free sensing of pH and silver nanoparticles using an "OR" logic gate.

Ka-Ho Leung, D. Chan, C. Leung, 2012, Analytica chimica acta.

A highly selective, label-free, homogenous luminescent switch-on probe for the detection of nanomolar transcription factor NF-kappaB

D. Chan, C. Leung, Dik‐Lung Ma, 2011, Nucleic acids research.

Alkene cyclopropanation catalyzed by Halterman iron porphyrin: participation of organic bases as axial ligands.

Dik‐Lung Ma, C. Che, Kwok‐yin Wong, 2006, Dalton transactions.

Virtual screening and optimization of Type II inhibitors of JAK2 from a natural product library.

Hui Yang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2014, Chemical communications.

Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2019, International journal of molecular sciences.

A Long-Lived Phosphorescence Amplification System Integrated with Graphene Oxide and a Stable Split G-Quadruplex Protector as an Isothermal "Off-On" Biosensor for the HBV Gene.

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2020, ACS applied bio materials.

Simple DNA-based logic gates responding to biomolecules and metal ions

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013 .

Ytterbium(III) triflate catalyzed annulation of propargylic 1,4-diols with aryl sulfonamides to give highly substituted pyrrole derivatives

C. Leung, Dik‐Lung Ma, P. Chan, 2014 .

Cucurbitacin E induces caspase-dependent apoptosis and protective autophagy mediated by ROS in lung cancer cells.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Chemico-biological interactions.

Platycodin D potentiates proliferation inhibition and apoptosis induction upon AKT inhibition via feedback blockade in non-small cell lung cancer cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Scientific Reports.

Pharmacological Inhibition of LSD1 for Cancer Treatment

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2018, Molecules.

Antcamphorols A-K, Cytotoxic and ROS Scavenging Triterpenoids from Antrodia camphorata.

C. Leung, Dik‐Lung Ma, X. Qiao, 2019, Journal of natural products.

Cytotoxic triterpenoids fromAntrodia camphorataas sensitizers of paclitaxel

C. Leung, Dik‐Lung Ma, X. Qiao, 2020 .

Identification of a natural product-like STAT3 dimerization inhibitor by structure-based virtual screening

D. Chan, C. Leung, Dik‐Lung Ma, 2014, Cell Death and Disease.

First Synthesis of an Oridonin-Conjugated Iridium(III) Complex for the Intracellular Tracking of NF-κB in Living Cells.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2017, Chemistry.

Aberrant JAK/STAT Signaling Suppresses TFF1 and TFF2 through Epigenetic Silencing of GATA6 in Gastric Cancer

C. Leung, Dik‐Lung Ma, J. Chou, 2016, International journal of molecular sciences.

CTnI diagnosis in myocardial infarction using G-quadruplex selective Ir(Ⅲ) complex as effective electrochemiluminescence probe.

Dik‐Lung Ma, Seyin Zou, Shujie Wu, 2022, Talanta.

The emerging role of KDM5A in human cancer

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2021, Journal of Hematology & Oncology.

Autophagic degradation of epidermal growth factor receptor in gefitinib-resistant lung cancer by celastrol.

C. Leung, Dik‐Lung Ma, Liang Liu, 2016, International journal of oncology.

Selective Inhibition of Lysine‐Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple‐Negative Breast Cancer Therapy

C. Leung, Dik‐Lung Ma, Chun‐Yuen Wong, 2018, Angewandte Chemie.

Structure-based design of flavone derivatives as c-myc oncogene down-regulators.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A G-quadruplex-selective luminescent probe with an anchor tail for the switch-on detection of thymine DNA glycosylase activity.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2016, Biosensors & bioelectronics.

Metal complexes for the detection of disease-related protein biomarkers

Dik-Lung Ma, Chung-Hang Leung, Modi Wang, 2016 .

Metal complexes as inhibitors of transcription factor activity

Modi Wang, D. Chan, C. Leung, 2013 .

An Iridium(III) Complex Inhibits JMJD2 Activities and Acts as a Potential Epigenetic Modulator.

C. Leung, Dik‐Lung Ma, Hai‐Jing Zhong, 2015, Journal of medicinal chemistry.

Simultaneous blocking of the pan‐RAF and S100B pathways as a synergistic therapeutic strategy against malignant melanoma

C. Leung, Dik‐Lung Ma, H. D. Wang, 2020, Journal of cellular and molecular medicine.

Group 9 metal-based inhibitors of β-amyloid (1–40) fibrillation as potential therapeutic agents for Alzheimer's disease

D. Chan, C. Leung, Dik‐Lung Ma, 2011 .

A natural product-like JAK2/STAT3 inhibitor induces apoptosis of malignant melanoma cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2017, PloS one.

Title A natural product-like JAK 2 / STAT 3 inhibitor induces apoptosisof malignant melanoma cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2017 .

Comprehensive Quantitative Analysis of 32 Chemical Ingredients of a Chinese Patented Drug Sanhuang Tablet

Dik-Lung Ma, Chung-Hang Leung, C. Leung, 2017, Molecules.

5-N-methylated quindoline derivatives as telomeric g-quadruplex stabilizing ligands: effects of 5-N positive charge on quadruplex binding affinity and cell proliferation.

Dik-Lung Ma, Kwok-Yin Wong, Jin-Qiang Hou, 2008, Journal of medicinal chemistry.

Selective Inhibition of Lysine-Specific Demethylase 5A (KDM5A) Using a Rhodium(III) Complex for Triple-Negative Breast Cancer Therapy.

C. Leung, Dik‐Lung Ma, Chun‐Yuen Wong, 2018, Angewandte Chemie.

Drug repositioning by structure-based virtual screening.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013, Chemical Society reviews.

Evaluation of Cinnamomum osmophloeum Kanehira Extracts on Tyrosinase Suppressor, Wound Repair Promoter, and Antioxidant

C. Leung, Dik‐Lung Ma, Z. Wen, 2015, TheScientificWorldJournal.

A label-free triplex-to-G-qadruplex molecular switch for sensitive fluorescent detection of acetamiprid.

Lihua Lu, Dik-Lung Ma, Dik‐Lung Ma, 2018, Talanta.

Structure-based repurposing of FDA-approved drugs as inhibitors of NEDD8-activating enzyme.

D. Chan, C. Leung, Dik‐Lung Ma, 2014, Biochimie.

Simple and convenient G-quadruplex-based turn-on fluorescence assay for 3' → 5' exonuclease activity.

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2011, Analytical chemistry.

Development of a Sensitive Luminescent Probe to Uncover New BRD4 Inhibitors in Living Cells

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2023, SSRN Electronic Journal.

Development of a luminescent G-quadruplex-selective iridium(III) complex for the label-free detection of adenosine

C. Leung, Dik‐Lung Ma, Hai‐Jing Zhong, 2016, Scientific Reports.

Flavonoid Dimers as Bivalent Modulators for P‐Glycoprotein‐Based Multidrug Resistance: Structure–Activity Relationships

L. Chow, Dik‐Lung Ma, T. Chow, 2009, ChemMedChem.

A rhodium(III)-based inhibitor of autotaxin with antiproliferative activity.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2017, Biochimica et biophysica acta. General subjects.

Label-Free Luminescent Switch-On Probe for Ochratoxin A Detection Using a G-Quadruplex-Selective Iridium(III) Complex.

Lihua Lu, Dik-Lung Ma, Chung-Hang Leung, 2015, ACS applied materials & interfaces.

A Rhodium(III)-Based Inhibitor of Lysine-Specific Histone Demethylase 1 as an Epigenetic Modulator in Prostate Cancer Cells.

C. Leung, Dik‐Lung Ma, Jiaxin Liang, 2017, Journal of medicinal chemistry.

Luminescent Iridium(III) Complexes Supported by N-Heterocyclic Carbene-based C^C^C-Pincer Ligands and Aromatic Diimines

C. Leung, Dik‐Lung Ma, Lai‐Hon Chung, 2015, Scientific Reports.

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

Dik‐Lung Ma, S. Cheng, C. Che, 2010, Molecular Cancer Therapeutics.

Butyrate mediates nucleotide‐binding and oligomerisation domain (NOD) 2‐dependent mucosal immune responses against peptidoglycan

C. Leung, Dik‐Lung Ma, W. Lam, 2009, European journal of immunology.

Pathologically Activated Neuroprotection via Uncompetitive Blockade of N-Methyl-d-aspartate Receptors with Fast Off-rate by Novel Multifunctional Dimer Bis(propyl)-cognitin*

Dik‐Lung Ma, Jun Xia, Y. Pang, 2010, The Journal of Biological Chemistry.

A rapid and label-free DNA-based interference reduction nucleic acid amplification strategy for viral RNA detection.

F. Chen, C. Leung, Dik‐Lung Ma, 2021, Biosensors & bioelectronics.

A highly sensitive G-quadruplex-based luminescent switch-on probe for the detection of polymerase 3'-5' proofreading activity.

Ka-Ho Leung, D. Chan, C. Leung, 2013, Methods.

Platycodin D induces apoptosis and triggers ERK- and JNK-mediated autophagy in human hepatocellular carcinoma BEL-7402 cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2015, Acta Pharmacologica Sinica.

Isocryptotanshinone, a STAT3 inhibitor, induces apoptosis and pro-death autophagy in A549 lung cancer cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Journal of drug targeting.

Development of an Iridium(III) Complex as a G-Quadruplex Probe and Its Application for the G-Quadruplex-Based Luminescent Detection of Picomolar Insulin.

Modi Wang, C. Leung, Dik‐Lung Ma, 2016, Analytical chemistry.

Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate.

D. Chan, C. Leung, Dik‐Lung Ma, 2011, The Analyst.

Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Chemical record.

A G-triplex luminescent switch-on probe for the detection of mung bean nuclease activity.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2015, Journal of materials chemistry. B.

Discovery of a VHL and HIF1α interaction inhibitor with in vivo angiogenic activity via structure-based virtual screening.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2016, Chemical communications.

Antagonism of mTOR Activity by a Kinetically Inert Rhodium(III) Complex.

Ka-Ho Leung, D. Chan, C. Leung, 2014, ChemPlusChem.

Hit identification of IKKβ natural product inhibitor

D. Chan, C. Leung, Dik‐Lung Ma, 2013, BMC Pharmacology and Toxicology.

Hit identification of IKKβ natural product inhibitor

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2013, BMC Pharmacology and Toxicology.

Structure‐Based Repurposing of FDA‐Approved Drugs as TNF‐α Inhibitors

Dik-Lung Ma, Daniel Shiu-Hin Chan, Chung-Hang Leung, 2011, ChemMedChem.

Identification of natural product fonsecin B as a stabilizing ligand of c-myc G-quadruplex DNA by high-throughput virtual screening.

Fang Yang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2010, Chemical communications.

Identification of a New Class of FtsZ Inhibitors by Structure-Based Design and in Vitro Screening

Ning Sun, Ruben Abagyan, Dik-Lung Ma, 2013, J. Chem. Inf. Model..

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of gene deletion.

D. Chan, C. Leung, Dik‐Lung Ma, 2012, Chemical communications.

An iridium(III) complex-based chemosensor for the detection of thiourea in living cells

C. Leung, Dik‐Lung Ma, Chao Yang, 2017 .

G-quadruplex-based logic gates for HgII and AgI ions employing a luminescent iridium(iii) complex and extension of metal-mediated base pairs by polymerase.

Modi Wang, Sheng Lin, C. Leung, 2015, Journal of materials chemistry. B.

Ubiquitination Regulators Discovered by Virtual Screening for the Treatment of Cancer

C. Leung, Dik‐Lung Ma, Chun Wu, 2021, Frontiers in Cell and Developmental Biology.

A long lifetime switch-on iridium(III) chemosensor for the visualization of cysteine in live zebrafish.

Modi Wang, C. Leung, Dik‐Lung Ma, 2016, Chemical communications.

Label-free detection of sub-nanomolar lead(II) ions in aqueous solution using a metal-based luminescent switch-on probe.

Ka-Ho Leung, D. Chan, C. Leung, 2013, Biosensors & bioelectronics.

Title Luminescent detection of DNA-binding proteins

D. Chan, C. Leung, Dik‐Lung Ma, 2012 .

A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Analytica chimica acta.

Rhodium(III)-Based Inhibitor of the JMJD3-H3K27me3 Interaction and Modulator of the Inflammatory Response.

C. Leung, Dik‐Lung Ma, Chun‐Yuen Wong, 2018, Inorganic Chemistry.

The application of a G-quadruplex based assay with an iridium(iii) complex to arsenic ion detection and its utilization in a microfluidic chip.

C. Leung, Dik‐Lung Ma, K. Ren, 2017, Journal of materials chemistry. B.

Group 8–9 Metal-Based Luminescent Chemosensors for Protein Biomarker Detection

C. Leung, Dik‐Lung Ma, Chun Wu, 2018, Journal of Analysis and Testing.

Application of label-free techniques in microfluidic for biomolecules detection and circulating tumor cells analysis

Dik-Lung Ma, Chun Wu, Guodong Li, 2019, TrAC Trends in Analytical Chemistry.

PTEN Activation by DNA Damage Induces Protective Autophagy in Response to Cucurbitacin B in Hepatocellular Carcinoma Cells

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Oxidative medicine and cellular longevity.

Interference Reduction Biosensing Strategy for Highly Sensitive microRNA Detection.

C. Leung, Dik‐Lung Ma, Ling Wang, 2022, Analytical chemistry.

Inhibition of Beta-Amyloid Fibrillation by Luminescent Iridium(III) Complex Probes

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Scientific Reports.

An Individual Nanocube-Based Plasmonic Biosensor for Real-Time Monitoring the Structural Switch of the Telomeric G-Quadruplex.

C. Leung, Dik‐Lung Ma, Weibing Wu, 2016, Small.

Inhibition of the p53/hDM2 protein-protein interaction by cyclometallated iridium(III) compounds

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Oncotarget.

Determination of cell metabolite VEGF₁₆₅ and dynamic analysis of protein-DNA interactions by combination of microfluidic technique and luminescent switch-on probe.

Jin-Ming Lin, Sheng Lin, Dik-Lung Ma, 2016, Biosensors & bioelectronics.

Structure-guided discovery of a luminescent theranostic toolkit for living cancer cells and the imaging behavior effect†

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2020, Chemical science.

A Ruthenium(II) Complex Supported by Trithiacyclononane and Aromatic Diimine Ligand as Luminescent Switch-On Probe for Biomolecule Detection and Protein Staining

Sheng Lin, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2014, Scientific Reports.

Iridium(iii) complexes with 1,10-phenanthroline-based N^N ligands as highly selective luminescent G-quadruplex probes and application for switch-on ribonuclease H detection.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2016, Journal of materials chemistry. B.

A cyclometalated iridium(III) complex used as a conductor for the electrochemical sensing of IFN-γ

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Scientific Reports.

Polymerase chain reaction-based ultrasensitive detection of HBV DNA via G-quadruplex selective iridium(III) complex luminescent probe.

Dik‐Lung Ma, Shujie Wu, Seyin Zou, 2021, Talanta.

Label-Free Luminescent Oligonucleotide-Based Probes

Ka-Ho Leung, D. Chan, C. Leung, 2013 .

Ultrasensitive electrochemical detection of miRNA-21 by using an iridium(III) complex as catalyst.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2016, Biosensors & bioelectronics.

A Novel Tetradentate Ruthenium(II) Complex Containing Tris(2- Pyridylmethyl)amine (tpa) As An Inhibitor Of Beta-amyloid Fibrillation.

T. Lam, C. Leung, Dik‐Lung Ma, 2015, Current Alzheimer research.

Dual Inhibition And Monitoring Of Beta-amyloid Fibrillation By A Luminescent Iridium(III) Complex.

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Current Alzheimer research.

Current advancements in Aβ luminescent probes and inhibitors of Aβ aggregation.

Ka-Ho Leung, D. Chan, C. Leung, 2012, Current Alzheimer research.

A highly selective G-quadruplex-based luminescent switch-on probe for the detection of nanomolar strontium(II) ions in sea water

Ka-Ho Leung, D. Chan, C. Leung, 2012 .

Interference reduction isothermal nucleic acid amplification strategy for COVID-19 variant detection

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2022, Sensors and Actuators B: Chemical.

Turn-on Luminescent Probe for Hydrogen Peroxide Sensing and Imaging in Living Cells based on an Iridium(III) Complex–Silver Nanoparticle Platform

Chao Yang, C. Leung, Dik‐Lung Ma, 2017, Scientific Reports.

A selective oligonucleotide-based luminescent switch-on probe for the detection of nanomolar mercury(II) ion in aqueous solution.

D. Chan, C. Leung, Dik‐Lung Ma, 2009, Chemical communications.

Peptide‐Conjugated Long‐Lived Theranostic Imaging for Targeting GRPr in Cancer and Immune Cells

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2020, Angewandte Chemie.

Purified Astaxanthin from Haematococcus pluvialis Promotes Tissue Regeneration by Reducing Oxidative Stress and the Secretion of Collagen In Vitro and In Vivo

C. Leung, Dik‐Lung Ma, T. Hour, 2020, Oxidative medicine and cellular longevity.

Development of an Aptamer-Based Sensing Platform for Metal Ions, Proteins, and Small Molecules through Terminal Deoxynucleotidyl Transferase Induced G-Quadruplex Formation.

Chao Yang, Dik-Lung Ma, Chung-Hang Leung, 2015, ACS applied materials & interfaces.

Recent Development of G-Quadruplex Probes for Cellular Imaging.

Modi Wang, Sheng Lin, C. Leung, 2015, Current topics in medicinal chemistry.

A luminescence switch-on probe for terminal deoxynucleotidyl transferase (TdT) activity detection by using an iridium(III)-based i-motif probe.

Modi Wang, C. Leung, Dik‐Lung Ma, 2015, Chemical communications.

A MnO2 nanosheet-assisted GSH detection platform using an iridium(iii) complex as a switch-on luminescent probe.

C. Leung, Dik‐Lung Ma, C. Yang, 2017, Nanoscale.

A Highly Selective and Non-Reaction Based Chemosensor for the Detection of Hg2+ Ions Using a Luminescent Iridium(III) Complex

Modi Wang, D. Chan, C. Leung, 2013, PloS one.

A colorimetric chemosensor for Cu2+ ion detection based on an iridium(III) complex

Modi Wang, Ka-Ho Leung, Sheng Lin, 2014, Scientific Reports.

Chemoselective detection of alkyl halides via an iridium(III) luminescent probe

C. Leung, Dik‐Lung Ma, Chun Wu, 2018, Dyes and Pigments.

Inhibition of Janus kinase 2 by cyclometalated rhodium complexes

D. Chan, C. Leung, Dik‐Lung Ma, 2012 .

Iridium-based probe for luminescent nitric oxide monitoring in live cells

C. Leung, Dik‐Lung Ma, H. D. Wang, 2018, Scientific Reports.

A long-lived luminogenic iridium(III) complex for acetylacetone detection in environmental samples

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2020 .

Comprehensive quantitative analysis of Chinese patent drug YinHuang drop pill by ultra high-performance liquid chromatography quadrupole time of flight mass spectrometry.

C. Leung, Dik‐Lung Ma, Han-Dong Sun, 2016, Journal of pharmaceutical and biomedical analysis.

Astragalus Polysaccharide RAP Selectively Attenuates Paclitaxel-Induced Cytotoxicity Toward RAW 264.7 Cells by Reversing Cell Cycle Arrest and Apoptosis

C. Leung, Dik‐Lung Ma, Z. Bian, 2019, Front. Pharmacol..

A time-resolved ratiometric luminescent anthrax biomarker nanosensor based on an Ir(III) complex-doped coordination polymer network.

C. Leung, Dik‐Lung Ma, Lihua Lu, 2022, Journal of materials chemistry. B.

A label-free G-quadruplex-based mercury detection assay employing the exonuclease III-mediated cleavage of T–Hg2+–T mismatched DNA

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2015, Science and technology of advanced materials.

A G-quadruplex-based platform for the detection of Hg2+ ions using a luminescent iridium(III) complex

D. Chan, C. Leung, Dik‐Lung Ma, 2014 .

Structure Characterization and Immunomodulating Effects of Polysaccharides Isolated from Dendrobium officinale.

C. Leung, Dik‐Lung Ma, Q. Han, 2016, Journal of Agricultural and Food Chemistry.

Metal complexes as potential modulators of inflammatory and autoimmune responses

Sheng Lin, C. Leung, Dik‐Lung Ma, 2014, Chemical science.

Label-free luminescence switch-on detection of hepatitis C virus NS3 helicase activity using a G-quadruplex-selective probe

Ka-Ho Leung, Sheng Lin, C. Leung, 2014, Chemical science.

Label-free luminescence switch-on detection of T4 polynucleotide kinase activity using a G-quadruplex-selective probe.

Wei Wang, Dik-Lung Ma, Daniel Shiu-Hin Chan, 2014, Chemical communications.

Comprehensive quantitative analysis of Shuang-Huang-Lian oral liquid using UHPLC–Q-TOF-MS and HPLC-ELSD

C. Leung, Dik‐Lung Ma, Zhong-Zhen Zhao, 2014, Journal of Pharmaceutical and Biomedical Analysis.

Structure-based discovery of natural product-like protein inhibitors

C. Leung, Dik‐Lung Ma, 2014 .

Alisol B, a Novel Inhibitor of the Sarcoplasmic/Endoplasmic Reticulum Ca2+ ATPase Pump, Induces Autophagy, Endoplasmic Reticulum Stress, and Apoptosis

Dik‐Lung Ma, S. Cheng, C. Che, 2010, Molecular Cancer Therapeutics.

Stabilization of G-quadruplex DNA with platinum(II) Schiff base complexes: luminescent probe and down-regulation of c-myc oncogene expression.

C. Leung, Dik‐Lung Ma, C. Che, 2009, Chemistry.

Luminescent Strategies for Label-Free G-Quadruplex-Based Enzyme Activity Sensing.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Chemical record.

G-quadruplex-based logic gates for HgII and AgI ions employing a luminescent iridium(iii) complex and extension of metal-mediated base pairs by polymerase.

Modi Wang, Sheng Lin, C. Leung, 2015, Journal of materials chemistry. B.

Label-free luminescent switch-on detection of endonuclease IV activity using a G-quadruplex-selective iridium(III) complex.

Ka-Ho Leung, D. Chan, C. Leung, 2013, ACS applied materials & interfaces.

A Label-Free Luminescent Switch-On Assay for ATP Using a G-Quadruplex-Selective Iridium(III) Complex

Modi Wang, Ka-Ho Leung, D. Chan, 2013, PloS one.

A highly selective luminescent switch-on probe for histidine/histidine-rich proteins and its application in protein staining.

Dik‐Lung Ma, Y. Leung, Wing‐Leung Wong, 2008, Angewandte Chemie.

A metal-based inhibitor of tumor necrosis factor-α.

R. Abagyan, D. Chan, C. Leung, 2012, Angewandte Chemie.

Identification of a rhodium(iii) complex as a Wee1 inhibitor against TP53-mutated triple-negative breast cancer cells.

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2018, Chemical communications.

Development of Natural Product-Conjugated Metal Complexes as Cancer Therapies

C. Leung, Dik‐Lung Ma, Shasha Cheng, 2019, International journal of molecular sciences.

Structure‐Based Repurposing of FDA‐Approved Drugs as TNF‐α Inhibitors

D. Chan, C. Leung, Dik‐Lung Ma, 2011, ChemMedChem.

Psoralidin induced reactive oxygen species (ROS)-dependent DNA damage and protective autophagy mediated by NOX4 in breast cancer cells.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Metal complexes as potential modulators of inflammatory and autoimmune responses

Sheng Lin, C. Leung, Dik‐Lung Ma, 2014, Chemical science.

A tutorial review for employing enzymes for the construction of G-quadruplex-based sensing platforms.

Jin-jian Lu, C. Leung, Dik‐Lung Ma, 2016, Analytica chimica acta.

Discovery of a small-molecule inhibitor of STAT3 by ligand-based pharmacophore screening.

Modi Wang, Ka-Ho Leung, Sheng Lin, 2015, Methods.

First Synthesis of an Oridonin-Conjugated Iridium(III) Complex for the Intracellular Tracking of NF-κB in Living Cells.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2017, Chemistry.

Molecular modeling of drug-DNA interactions: virtual screening to structure-based design.

D. Chan, C. Leung, Dik‐Lung Ma, 2011, Biochimie.

Luminescent iridium(iii) complexes as COX-2-specific imaging agents in cancer cells.

C. Leung, Dik‐Lung Ma, Wanhe Wang, 2017, Chemical communications.

A rhodium(III) complex inhibits LPS-induced nitric oxide production and angiogenic activity in cellulo.

D. Chan, C. Leung, Dik‐Lung Ma, 2014, Journal of inorganic biochemistry.

A cell-impermeable luminogenic probe for near-infrared imaging of prostate-specific membrane antigen in prostate cancer microenvironments.

C. Leung, Dik‐Lung Ma, J. Wang, 2023, European journal of medicinal chemistry.

A long-lived phosphorescence iridium(III) complex as a switch on-off-on probe for live zebrafish monitoring of endogenous sulfide generation.

Sheng Lin, C. Leung, Dik‐Lung Ma, 2017, Biosensors & bioelectronics.

Platinum(II) complexes with dipyridophenazine ligands as human telomerase inhibitors and luminescent probes for G-quadruplex DNA.

Dik‐Lung Ma, C. Che, Siu-cheong Yan, 2009, Journal of the American Chemical Society.

Crystal violet as a fluorescent switch-on probe for i-motif: label-free DNA-based logic gate.

D. Chan, C. Leung, Dik‐Lung Ma, 2011, The Analyst.

Luminescent turn-on detection of Hg(II) via the quenching of an iridium(III) complex by Hg(II)-mediated silver nanoparticles

C. Leung, Dik‐Lung Ma, Guan-Jun Yang, 2017, Scientific Reports.