P. Vaupel

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Current status of knowledge and critical issues in tumor oxygenation. Results from 25 years research in tumor pathophysiology.

P. Vaupel, O. Thews, D. Kelleher, 1998, Advances in experimental medicine and biology.

Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review.

P. Okunieff, P. Vaupel, F. Kallinowski, 1989, Cancer research.

Enhanced effects of aminolaevulinic acid-based photodynamic therapy through local hyperthermia in rat tumours

P. Vaupel, O. Thews, D. Kelleher, 2003, British Journal of Cancer.

Tumor hypoxia: causative factors, compensatory mechanisms, and cellular response.

P. Vaupel, L. Harrison, 2004, The oncologist.

Pathophysiology of Solid Tumors

P. Vaupel, 2009 .

Factors governing hyperthermia-induced pH changes in Yoshida sarcomas.

P. Vaupel, F. Kallinowski, 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

TISSUE pH-DISTRIBUTION WITHIN MALIGNANT TUMORS AS MEASURED WITH ANTIMONY MICROELECTRODES

P. Vaupel, W. Müller-Klieser, J. Busse, 1981 .

Tumor hypoxia: definitions and current clinical, biologic, and molecular aspects.

P. Vaupel, M. Höckel, Michael Höckel, 2001, Journal of the National Cancer Institute.

Hypoxia in cancer: significance and impact on clinical outcome

P. Vaupel, A. Mayer, 2007, Cancer and Metastasis Reviews.

Detection and characterization of tumor hypoxia using pO2 histography.

Michael Höckel, Peter Vaupel, P. Vaupel, 2007, Antioxidants & redox signaling.

Hypoxia and aggressive tumor phenotype: implications for therapy and prognosis.

Peter Vaupel, P. Vaupel, 2008, The oncologist.

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

P Vaupel, P. Vaupel, M. Höckel, 1991, Cancer research.

Hypoxia-Driven Adenosine Accumulation: A Crucial Microenvironmental Factor Promoting Tumor Progression.

P. Vaupel, A. Mayer, 2016, Advances in experimental medicine and biology.

Metabolic microenvironment of tumor cells: a key factor in malignant progression.

P Vaupel, P. Vaupel, 2010, Experimental oncology.

Association between tumor hypoxia and malignant progression in advanced cancer of the uterine cervix.

P Vaupel, P. Vaupel, M. Mitze, 1996, Cancer research.

Divergent changes of flow through individual blood vessels upon localized heating.

M. Suntharalingam, P. Vaupel, J. Rhee, 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Intracapillary oxyhemoglobin saturation of malignant tumors in humans.

P Vaupel, P. Vaupel, W. Mueller‐Klieser, 1981, International journal of radiation oncology, biology, physics.

Intracapillary oxyhemoglobin saturation in malignant tumours with central or peripheral blood supply.

P. Vaupel, W. Müller-Klieser, W. Grunewald, 1980, European journal of cancer.

Intracapillary HbO2 saturation in tumor tissue of DS-carcinosarcoma during normoxia.

P. Vaupel, W. Grunewald, R. Manz, 1977, Advances in experimental medicine and biology.

Multipotent mesenchymal stromal cells are sensitive to thermic stress – potential implications for therapeutic hyperthermia

P. Vaupel, A. Grosu, N. Nicolay, 2020, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Hypofractionated re-irradiation of large-sized recurrent breast cancer with thermography-controlled, contact-free water-filtered infra-red-A hyperthermia: a retrospective study of 73 patients

P. Vaupel, H. Piazena, M. Notter, 2017, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[Hypoxia in cervical cancer: pathogenesis, characterization, and biological/clinical consequences].

P. Vaupel, M. Höckel, 2001, Zentralblatt fur Gynakologie.

Oxygen status of malignant tumors: pathogenesis of hypoxia and significance for tumor therapy.

P Vaupel, P. Vaupel, D. Kelleher, 2001, Seminars in oncology.

Intra- and intertumor heterogeneities in total, chronic, and acute hypoxia in xenografted squamous cell carcinomas

P. Vaupel, Constantin Maftei, C. Bayer, 2012, Strahlentherapie und Onkologie.

Oxygen Transport to Tissue XV

Duane F. Bruley, Peter Vaupel, P. Vaupel, 1994, Advances in Experimental Medicine and Biology.

Is the division of heated tissue into temperature equivalent zones suitable for estimation of tumor blood flow from thermal clearance curves?

P. Vaupel, F. Kallinowski, K. Groebe, 1987, International journal of radiation oncology, biology, physics.

Angiogenic activity of cervical carcinoma: assessment by functional magnetic resonance imaging-based parameters and a histomorphological approach in correlation with disease outcome.

M V Knopp, P Vaupel, G van Kaick, 1998, Clinical cancer research : an official journal of the American Association for Cancer Research.

Hypoxia-/HIF-1α-Driven Factors of the Tumor Microenvironment Impeding Antitumor Immune Responses and Promoting Malignant Progression.

P. Vaupel, G. Multhoff, 2018, Advances in experimental medicine and biology.

Accomplices of the Hypoxic Tumor Microenvironment Compromising Antitumor Immunity: Adenosine, Lactate, Acidosis, Vascular Endothelial Growth Factor, Potassium Ions, and Phosphatidylserine

P. Vaupel, G. Multhoff, 2017, Front. Immunol..

Commentary: A Metabolic Immune Checkpoint: Adenosine in Tumor Microenvironment

P. Vaupel, G. Multhoff, 2016, Front. Immunol..

Therapeutic Angiogenesis in Surgery and Oncology

P. Vaupel, M. Höckel, K. Schlenger, 1994 .

In vivo targets of recombinant human tumour necrosis factor-alpha: blood flow, oxygen consumption and growth of isotransplanted rat tumours.

P. Vaupel, F. Kallinowski, C. Schaefer, 1989, British Journal of Cancer.

Correlations between 31P-NMR spectroscopy and tissue O2 tension measurements in a murine fibrosarcoma.

P Okunieff, P Vaupel, P. Okunieff, 1989, Radiation research.

Tumor oxygenation: an appraisal of past and present concepts and a look into the future : Arisztid G. B. Kovách Lecture.

P. Vaupel, 2013, Advances in experimental medicine and biology.

Laser Doppler flux and tissue oxygenation of experimental tumours upon local hyperthermia and/or hyperglycaemia

P. Vaupel, M. Stohrer, W. K. Mayer, 2005, Journal of Cancer Research and Clinical Oncology.

The Role of the Microcirculation in the Treatment of Malignant Tumors: Facts and Fiction

P. Vaupel, B. Endrich, 2000 .

Acute effects of tumor necrosis factor-alpha or lymphotoxin on oxygenation and bioenergetic status in experimental tumors.

P. Vaupel, T. Engel, 1994, Advances in experimental medicine and biology.

Do changes in tumor blood flow necessarily lead to changes in tissue oxygenation and in bioenergetic status?

P. Vaupel, D. Kelleher, T. Engel, 1994, Advances in experimental medicine and biology.

Stable bioenergetic status despite substantial changes in blood flow and tissue oxygenation in a rat tumour.

P. Vaupel, D. Kelleher, T. Engel, 1994, British Journal of Cancer.

Oxygenation of mammary tumors: from isotransplanted rodent tumors to primary malignancies in patients.

P. Okunieff, P. Vaupel, M. Hoeckel, 1992, Advances in experimental medicine and biology.

Tumors growing in irradiated tissue: oxygenation, metabolic state, and pH.

P. Okunieff, P. Vaupel, F. Kallinowski, 1991, International journal of radiation oncology, biology, physics.

Oxygenation of tumors derived from ras transformed cells.

P. Vaupel, F. van Roy, F. Kallinowski, 1990, Advances in experimental medicine and biology.

Effects of pentobarbital anesthesia on the energy metabolism of murine tumors studied by in vivo 31P nuclear magnetic resonance spectroscopy.

P. Okunieff, S. Skates, E. Rummeny, 1988, Radiation research.

Effects of hydralazine-induced vasodilation on the energy metabolism of murine tumors studied by in vivo 31P-nuclear magnetic resonance spectroscopy.

P. Okunieff, P. Vaupel, F. Kallinowski, 1988, Journal of the National Cancer Institute.

31P nuclear magnetic resonance measurements of ATPase kinetics in malignant tumors.

P. Okunieff, P. Vaupel, L. Neuringer, 1989, Advances in experimental medicine and biology.

Radiation-induced changes in microcirculation and interstitial fluid pressure affecting the delivery of macromolecules and nanotherapeutics to tumors

P. Vaupel, G. Multhoff, 2012, Front. Oncol..

Hypoxia-Associated Marker CA IX Does Not Predict the Response of Locally Advanced Rectal Cancers to Neoadjuvant Chemoradiotherapy.

P. Vaupel, W. Mueller‐Klieser, A. Mayer, 2016, Advances in experimental medicine and biology.

Oxygen diffusivity in tumor tissue (DS-carcinosarcoma) under temperature conditions within the range of 20--40 degrees C.

P Vaupel, P. Vaupel, J. Grote, 1977, Pflugers Archiv : European journal of physiology.

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

P. Vaupel, M. Höckel, K. Schlenger, 1991, Cancer research.

Severe hypoxia is a typical characteristic of human hepatocellular carcinoma: Scientific fact or fallacy?

P. Vaupel, T. Cramer, 2022, Journal of hepatology.

Oxygenation status of urogenital tumors.

P. Vaupel, M. Hoeckel, A. Mayer, 2011, Advances in experimental medicine and biology.

HIF-mediated hypoxic response is missing in severely hypoxic uterine leiomyomas.

A. Wree, P. Vaupel, M. Hoeckel, 2010, Advances in experimental medicine and biology.

Carbonic Anhydrase IX Expression and Tumor Oxygenation Status Do Not Correlate at the Microregional Level in Locally Advanced Cancers of the Uterine Cervix

P. Vaupel, M. Höckel, A. Mayer, 2005, Clinical Cancer Research.

Microregional Expression of Glucose Transporter-1 and Oxygenation Status: Lack of Correlation in Locally Advanced Cervical Cancers

A. Wree, P. Vaupel, M. Höckel, 2005, Clinical Cancer Research.

Lack of Correlation between Expression of HIF-1α Protein and Oxygenation Status in Identical Tissue Areas of Squamous Cell Carcinomas of the Uterine Cervix

A. Wree, P. Vaupel, H. Pilch, 2004, Cancer Research.

Oxygenation Status of Cervical Carcinomas Before and During Spinal Anesthesia for Application of Brachytherapy

R. Pötter, P. Vaupel, B. Gustorff, 2003, Strahlentherapie und Onkologie.

Oxygenation of cervix cancers: impact of clinical and pathological parameters.

P. Vaupel, M. Höckel, 2003, Advances in experimental medicine and biology.

Evidence for and against hypoxia as the primary cause of tumor aggressiveness.

P. Okunieff, P. Vaupel, M. Höckel, 2003, Advances in experimental medicine and biology.

Pancreatic tumors show high levels of hypoxia: regarding Koong et al. IJROBP 2000;48:919-922.

P. Vaupel, O. Thews, D. Kelleher, 2001, International journal of radiation oncology, biology, physics.

Quantitative assessment of hypoxia kinetic models by a cross-study of dynamic 18F-FAZA and 15O-H2O in head and neck tumors

S. Ziegler, P. Vaupel, J. Wilkens, 2009, 2009 IEEE Nuclear Science Symposium Conference Record (NSS/MIC).

Enhancement of oxidative cell injury and antitumor effects of localized 44 degrees C hyperthermia upon combination with respiratory hyperoxia and xanthine oxidase.

P. Vaupel, O. Thews, D. Kelleher, 1998, Cancer research.

Relationship between hemoglobin levels and tumor oxygenation

P. Vaupel, M. Höckel, A. Mayer, 2008 .

Hyperoxia-induced improvement of the in vitro response to gemcitabine in transitional cell carcinoma.

P. Albers, P. Vaupel, D. Schmidt, 2005, Anticancer research.

What Is the Meaning of an Oxygen Measurement? : Analysis of Methods Purporting to Measure Oxygen in Targeted Tissues.

B. Pogue, A. Flood, P. Vaupel, 2021, Advances in experimental medicine and biology.

Adenosine can thwart antitumor immune responses elicited by radiotherapy

P. Vaupel, G. Multhoff, 2016, Strahlentherapie und Onkologie.

Can respiratory hyperoxia mitigate adenosine-driven suppression of antitumor immunity?

P. Vaupel, A. Mayer, 2015, Annals of translational medicine.

Erythropoiesis-Stimulating Agents: Favorable Safety Profile When Used as Indicated

P. Vaupel, J. Dunst, M. Nowrousian, 2008, Strahlentherapie und Onkologie.

wIRA: hyperthermia as a treatment option for intracellular bacteria, with special focus on Chlamydiae and Mycobacteria

P. Vaupel, G. Pluschke, N. Borel, 2020, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Adjuvant temozolomide-based chemoradiotherapy versus radiotherapy alone in patients with WHO III astrocytoma

C. Sommer, P. Vaupel, A. Giese, 2015, Strahlentherapie und Onkologie.

Oxygenation of human tumors: the Mainz experience.

P. Vaupel, O. Thews, D. Kelleher, 1998, Strahlentherapie und Onkologie (Print).

Possible mechanisms involved in tumor radiosensitization following nicotinamide administration.

P. Vaupel, D. Kelleher, 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

A new photometric method for oxygen consumption measurements in cell suspensions.

P. Vaupel, W. Mueller‐Klieser, R. Zander, 1986, Journal of applied physiology.

Experimental evidence for a hyperthermia-induced breakdown of tumor blood flow during normoglycemia

P. Vaupel, W. Müller-Klieser, H. Gabbert, 2004, Journal of Cancer Research and Clinical Oncology.

Therapeutic angiogenesis.

P. Vaupel, W. Frishman, T. Kissel, 1993, Archives of surgery.

Textural features of hypoxia PET predict survival in head and neck cancer during chemoradiotherapy

P. Vaupel, M. Mix, P. Meyer, 2019, European Journal of Nuclear Medicine and Molecular Imaging.

Tumor Blood Flow

P. Vaupel, 2000 .

The clinical importance of assessing tumor hypoxia: relationship of tumor hypoxia to prognosis and therapeutic opportunities.

P. Vaupel, A. Mayer, 2015, Antioxidants & redox signaling.

Blood flow and oxygenation status of gastrointestinal tumors.

P. Vaupel, D. Kelleher, 2012, Advances in experimental medicine and biology.

Prognostic potential of the pre-therapeutic tumor oxygenation status.

P. Vaupel, 2009, Advances in experimental medicine and biology.

Role of the tumor microenvironment in the activity and expression of the p-glycoprotein in human colon carcinoma cells.

P. Vaupel, O. Thews, D. Kelleher, 2007, Oncology reports.

Beyond Anaemia Management: Evolving Role of Erythropoietin Therapy in Neurological Disorders, Multiple Myeloma and Tumour Hypoxia Models

P. Vaupel, M. Boogaerts, M. Mittelman, 2005, Oncology.

P. Johnston, P. Vaupel, D. Khayat, 2005, Oncology.

Summary: Of oxygen, hemoglobin, and tumor treatment

P. Vaupel, R. Bugat, 2004 .

Lack of association between tumor hypoxia, GLUT-1 expression and glucose uptake in experimental sarcomas.

P. Vaupel, O. Thews, D. Kelleher, 2003, Advances in experimental medicine and biology.

Impact of Anemia Prevention by Recombinant Human Erythropoietin on the Sensitivity of Xenografted Glioblastomas to Fractionated Irradiation

H. Sack, P. Vaupel, O. Thews, 2003, Strahlentherapie und Onkologie.

Oxygenation of carcinomas of the uterine cervix: evaluation by computerized O2 tension measurements.

P. Vaupel, M. Höckel, K. Schlenger, 1991, Cancer research.

No improvement in perfusion and oxygenation of experimental tumors upon application of vasodilator drugs.

P. Vaupel, O. Thews, D. Kelleher, 2001, International journal of oncology.

[Tumoral vascular density in breast tumors and their effect on recurrence-free survival].

P. Vaupel, B. Endrich, 1995, Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen.

Tumor oxygenation under normobaric and hyperbaric hyperoxia. Impact of various inspiratory CO2 concentrations.

P. Vaupel, O. Thews, D. Kelleher, 1997, Advances in experimental medicine and biology.

Tumor Oxygenation Under Normobaric and Hyperbaric Hyperoxia

P. Vaupel, O. Thews, D. Kelleher, 1997 .

Angiogenesis determines blood flow, metabolism, growth rate, and ATPase kinetics of tumors growing in an irradiated bed: 31P and 2H nuclear magnetic resonance studies.

P. Okunieff, P. Vaupel, K. Beshah, 1991, Cancer research.

Interaction of oxygen partial pressure and energy metabolism with the relaxation rate of inorganic phosphate: a 31P NMR study.

P. Okunieff, P. Vaupel, L. Neuringer, 1990, Advances in experimental medicine and biology.

Effects of hydralazine on in vivo tumor energy metabolism, hematopoietic radiation sensitivity, and cardiovascular parameters.

P. Okunieff, P. Vaupel, H. Suit, 1989, International journal of radiation oncology, biology, physics.

Evaluation of tumor energy metabolism and microvascular blood flow after glucose or mannitol administration using 31P nuclear magnetic resonance spectroscopy and laser Doppler flowmetry.

P. Okunieff, P. Vaupel, L. Neuringer, 1989, International journal of radiation oncology, biology, physics.

Blood flow, tissue oxygenation, pH distribution, and energy metabolism of murine mammary adenocarcinomas during growth.

P. Okunieff, P. Vaupel, L. Neuringer, 1989, Advances in experimental medicine and biology.

Blood flow, tissue oxygenation, and pH-distribution in malignant tumors upon localized hyperthermia. Basic pathophysiological aspects and the role of various thermal doses.

P. Vaupel, F. Kallinowski, W. Müller-Klieser, 1983, Strahlentherapie.

FSaII mouse tumor metabolic changes with different doses of glucose measured by 31P nuclear magnetic resonance.

P. Vaupel, J. Koutcher, L. Gerweck, 1988, Cancer research.

Role of hypovolemic hemoconcentration in dose-dependent flow decline observed in murine tumors after intraperitoneal administration of glucose or mannitol.

P. Okunieff, P. Vaupel, 1988, Cancer research.

Strong adverse prognostic impact of hyperglycemic episodes during adjuvant chemoradiotherapy of glioblastoma multiforme

P. Vaupel, A. Giese, A. Mayer, 2014, Strahlentherapie und Onkologie.

Tumor hypoxia as a function of hemoglobin concentration and tumor perfusion.

P. Vaupel, D. Kelleher, M. Hoeckel, 2010, International journal of radiation oncology, biology, physics.

Imaging of tumor physiology: impacts on clinical radiation oncology.

P. Vaupel, M. Molls, S. Astner, 2010, Experimental oncology.

Hypoxic Tumor Microenvironments Suppress Anti-Tumor Immunity: The Role of Adenosine, Lactate, Acidosis, VEGF, Potassium Ions, and Phosphatidylserine

P. Vaupel, G. Multhoff, 2010 .

Solid tumours arising from differently pre-oxygenated cells: Comparable growth rates despite dissimilar tissue oxygenation

A. Wree, P. Vaupel, D. Kelleher, 2009, International journal of radiation biology.

Carcinomas of the Uterine Cervix : Evaluation by Computerized O 2 Tension Measurements

P. Vaupel, K. Schlenger, C. Knoop, 2006 .

Acute changes of systemic parameters in tumour-bearing rats, and of tumour glucose, lactate, and ATP levels upon local hyperthermia and/or hyperglycaemia

P. Vaupel, M. Stohrer, C. Schaefer, 2005, Journal of Cancer Research and Clinical Oncology.

Microregional distributions of glucose, lactate, ATP and tissue pH in experimental tumours upon local hyperthermia and/or hyperglycaemia

P. Vaupel, C. Schaefer, W. K. Mayer, 2005, Journal of Cancer Research and Clinical Oncology.

Energy Status of Malignant Tumors in Patients and Experimental Animals

C. Streffer, P. Vaupel, W. Mueller‐Klieser, 2000 .

Enhanced radiosensitivity in experimental tumours following erythropoietin treatment of chemotherapy-induced anaemia.

P. Vaupel, O. Thews, D. Kelleher, 1998, British Journal of Cancer.

Hypoxyradiotherapy: lack of experimental evidence for a preferential radioprotective effect on normal versus tumor tissue as shown by direct oxygenation measurements in experimental sarcomas.

P. Vaupel, O. Thews, D. Kelleher, 1997, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Blood flow, oxygenation, and bioenergetic status of tumors after erythropoietin treatment in normal and anemic rats.

P. Vaupel, O. Thews, D. Kelleher, 1996, Cancer research.

OXYGENATION AND BIOENERGETIC STATUS OF HUMAN TUMORS

P. Vaupel, W. Mueller‐Klieser, 1992 .

Impact of localized microwave hyperthermia on the oxygenation status of malignant tumors.

P. Vaupel, G. Thews, R. Manz, 1982, Advances in experimental medicine and biology.

Autonomic Functions in Human Physiology

P. Vaupel, G. Thews, 1984 .

Evidence for and against a tumor type-specific vascularity.

P. Vaupel, H. Gabbert, 1986, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

Cell line and growth site as relevant parameters governing tumor tissue oxygenation.

P. Vaupel, W. Mueller‐Klieser, 1986, Advances in experimental medicine and biology.

Tumour-growth inhibition by induced hyperglycaemia/hyperlactacidaemia and localized hyperthermia.

P. Vaupel, D. Kelleher, S. Walenta, 1996, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Strikingly high respiratory quotients: a further characteristic of the tumor pathophysiome.

P. Vaupel, 2008, Advances in experimental medicine and biology.

Basal HIF-1α expression levels are not predictive for radiosensitivity of human cancer cell lines

M. Molls, P. Vaupel, G. Multhoff, 2012, Strahlentherapie und Onkologie.

Microregional Expression of GlucoseTransporter-1 and Oxygenation Status : Lackof Correlation in LocallyAdvanced Cervical Cancers

A. Wree, P. Vaupel, A. Mayer, 2005 .

Inclusion of PET-CT into planning of primary or neoadjuvant chemoradiotherapy of esophageal cancer improves prognosis

P. Vaupel, M. Miederer, D. Wollschläger, 2017, Strahlentherapie und Onkologie.

Adipokine expression in brown and white adipocytes in response to hypoxia

A. Wree, G. Gerken, A. Canbay, 2011, Journal of Endocrinological Investigation.

Malignant Tumors and the Microcirculation

P. Vaupel, B. Endrich, 2019, Clinically Applied Microcirculation Research.

Laser Doppler flowmetry in subepidermal tumours and in normal skin of rats during localized ultrasound hyperthermia.

P. Vaupel, M. Kluge, M. Ambrož, 1988, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Cervical carcinoma: standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival

M. Knopp, P. Vaupel, H. Hawighorst, 1999, Magnetic Resonance Materials in Physics, Biology and Medicine.

Response to commentary by Champ and Klement

P. Vaupel, A. Giese, A. Mayer, 2015, Strahlentherapie und Onkologie.

Blood flow, vascular resistance and oxygen availability in malignant tumours upon intravenous flunarizine.

P. Vaupel, H. Menke, 1987, Advances in experimental medicine and biology.

The Impact of Tumor Biology on Cancer Treatment and Multidisciplinary Strategies

P. Vaupel, M. Anscher, M. Molls, 2009 .

Role of Hypoxia and the Adenosine System in Immune Evasion and Prognosis of Patients with Brain Metastases of Melanoma: A Multiplex Whole Slide Immunofluorescence Study

P. Vaupel, W. Roth, C. Loquai, 2020, Cancers.

Erythropoietin restores the anemia-induced reduction in radiosensitivity of experimental human tumors in nude mice.

P. Vaupel, O. Thews, M. Stuschke, 2003, International journal of radiation oncology, biology, physics.

The impact of treatment for genital cancer on quality of life and body image--results of a prospective longitudinal 10-year study.

P. Vaupel, D. Kelleher, Marcus Schmidt, 2004, Gynecologic oncology.

The physician-patient relationship before cancer treatment: a prospective longitudinal study.

P. Vaupel, D. Kelleher, R. Seufert, 2004, Gynecologic oncology.

Imaging tumor hypoxia: Blood-borne delivery of imaging agents is fundamentally different in hypoxia subtypes

P. Vaupel, A. Mayer, 2014 .

Verapamil inhibits the respiration rate of cancer cells.

P. Vaupel, W. Mueller‐Klieser, 1986, Advances in experimental medicine and biology.

Can erythropoietin improve tumor oxygenation?

P. Vaupel, O. Thews, D. Kelleher, 1998, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

Effect of intraperitoneal versus intravenous glucose administration on laser Doppler flow in murine FSaII tumors and normal skin.

P. Okunieff, P. Vaupel, J. Kalmus, 1989, Cancer Research.

Response of tumour red blood cell flux to hyperthermia and/or hyperglycaemia.

P. Okunieff, P. Vaupel, M. Kluge, 1989, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

How to improve the uterotomy healing. I. Effects of fibrin and tumor necrosis factor-alpha in the rat uterotomy model.

P. Vaupel, M. Höckel, R. Schwab, 1994, The Journal of surgical research.

PO2 distribution in tumor tissue of DS-carcinosarcoma.

P. Vaupel, G. Thews, 1974, Oncology.

Tumor blood flow and O2 availability during hemodilution.

P. Vaupel, W. Müller-Klieser, C. Jung, 1984, Advances in experimental medicine and biology.

Blood flow and oxygenation status of head and neck carcinomas.

P. Vaupel, 1997, Advances in experimental medicine and biology.

Abnormal Microvasculature and Defective Microcirculatory Function in Solid Tumors

P. Vaupel, 2006 .

Effectiveness of respiratory hyperoxia, of normobaric and of hyperbaric oxygen atmospheres in improving tumor oxygenation.

P. Vaupel, W. Mueller‐Klieser, R. Manz, 1984, Advances in experimental medicine and biology.

Oxygen diffusion constants D and K of tumor tissue (DS-carcinosarcoma) and their temperature dependence.

P. Vaupel, J. Grote, R. Süsskind, 1977, Advances in experimental medicine and biology.

Blood flow, oxygenation, metabolic and energetic status in different clonal subpopulations of a rat rhabdomyosarcoma.

P. Vaupel, O. Thews, D. Kelleher, 1998, International journal of oncology.

Heterogeneous oxygen partial pressure and pH distribution in C3H mouse mammary adenocarcinoma.

P. Vaupel, S. Frinak, H. Bicher, 1981, Cancer research.

l-glutamine: a major substrate for tumor cells in vivo?

P. Vaupel, F. Kallinowski, H. Fortmeyer, 2004, Journal of Cancer Research and Clinical Oncology.

Action of the antileukemic and anti‐HTLV‐III (anti‐HIV) agent avarol on the levels of superoxide dismutases and glutathione peroxidase activities in L5178y mouse lymphoma cells

P. Vaupel, F. Kallinowski, M. Gašić, 1988, Cell biochemistry and function.

Blood flow and oxygen supply to human mammary carcinomas transplanted into nude rats.

P. Vaupel, F. Kallinowski, S. Dave, 1985, Advances in experimental medicine and biology.

Effect of Localized Hyperthermia on Tumor Blood Flow and Oxygenation

P. Vaupel, W. Mueller‐Klieser, R. Manz, 1984 .

Tumour oxygenation under normobaric and hyperbaric conditions.

P. Vaupel, W. Mueller‐Klieser, R. Manz, 1983, The British journal of radiology.

Relationship between size and oxygenation status of malignant tumors.

P. Vaupel, G. Thews, R. Manz, 1983, Advances in experimental medicine and biology.

Evaluation of hypoxia-mediated growth factors in a novel bladder cancer animal model.

P. Vaupel, D. Schmidt, S. Müller, 2007, Anticancer research.

Effect of hyperthermia on tumor blood flow.

P. Vaupel, W. Müller-Klieser, 1984, Biorheology.

Physiological responses of intratumour pO2 and pH to hyperthermia and radiation treatment.

P. Vaupel, H. Bicher, 1980 .

Radiation-Associated Angiosarcoma of the Breast and Chest Wall Treated with Thermography-Controlled, Contactless wIRA-Hyperthermia and Hypofractionated Re-Irradiation

P. Vaupel, A. Thomsen, M. Notter, 2021, Cancers.

Relevant parameters for describing the oxygenation status of solid tumors.

P. Vaupel, O. Thews, 1996, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

Acute effects of tumor necrosis factor alpha or lymphotoxin on global blood flow, laser Doppler flux, and bioenergetic status of subcutaneous rodent tumors.

P. Vaupel, C. Schaefer, T. Engel, 1992, Cancer research.

Association between host tissue vascularity and the prognostically relevant tumor vascularity in human cervical cancer.

P. Vaupel, M. Höckel, K. Schlenger, 2001, International journal of oncology.

The effect of erythropoietin on tumor oxygenation in normal and anemic rats.

P. Vaupel, D. Kelleher, E. Friedrich, 1994, Advances in experimental medicine and biology.

Microcirculatory and pH alterations in isotransplanted rat and xenotransplanted human tumors associated with hyperthermia.

P. Vaupel, F. Kallinowski, H. Fortmeyer, 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Hemodilution in isolated tumor perfusion.

P. Vaupel, W. Müller-Klieser, 1984, Biorheology.

ESPEN expert group recommendations for action against cancer-related malnutrition.

D. Lobo, P. Calder, P. Vaupel, 2017, Clinical nutrition.

Pathophysiological Mechanisms of Hyperthermia in Cancer Therapy

P. Vaupel, 1990 .

Physiological effects of hyperthermia.

P. Vaupel, F. Kallinowski, 1987, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Blood perfusion and microenvironment of human tumors : implications for clinical radiooncology

Michael Molls, Peter Vaupel, P. Vaupel, 1998 .

Intratumoral pO2 predicts survival in advanced cancer of the uterine cervix.

P Vaupel, P. Vaupel, M. Mitze, 1993, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Correction to: Oxygenation Status of Malignant Tumors vs. Normal Tissues: Critical Evaluation and Updated Data Source Based on Direct Measurements with pO2 Microsensors

A. Flood, P. Vaupel, H. Swartz, 2021, Applied Magnetic Resonance.

Revisiting the Warburg effect: historical dogma versus current understanding

P. Vaupel, G. Multhoff, 2020, The Journal of physiology.

Effect of CO2 and lactic acid on intracellular pH of ascites tumor cells.

P. Vaupel, W. Müller-Klieser, C. Albers, 1981, Respiration physiology.

Modulation of tumor oxygenation.

P Vaupel, O Thews, P. Vaupel, 1998, International journal of radiation oncology, biology, physics.

Blood flow and oxygenation status of human tumors

P. Vaupel, H. Feldmann, M. Molls, 1999, Strahlentherapie und Onkologie.

Effect of percentual water content in tissues and liquids on the diffusion coefficients of O2, CO2, N2, and H2

P. Vaupel, 1976, Pflügers Archiv.

Non-bicarbonate buffering of ascites tumor cells in the rat as titrated by strong acids.

P. Vaupel, C. Albers, 1981, Respiration physiology.

Evaluation of oxygen diffusion distances in human breast cancer xenografts using tumor-specific in vivo data: role of various mechanisms in the development of tumor hypoxia.

P Vaupel, K Groebe, P. Vaupel, 1988, International journal of radiation oncology, biology, physics.

NK cell-based therapeutics for lung cancer

P. Vaupel, G. Multhoff, A. Pockley, 2019, Expert opinion on biological therapy.

Blood flow, metabolism, cellular microenvironment, and growth rate of human tumor xenografts.

P. Okunieff, P. Vaupel, F. Kallinowski, 1989, Cancer research.

Pyruvate kinase type M2: a crossroad in the tumor metabolome

P. Vaupel, C. Boschek, H. Grimm, 2002, British Journal of Nutrition.

Glucose uptake, lactate release, ketone body turnover, metabolic micromilieu, and pH distributions in human breast cancer xenografts in nude rats.

P. Vaupel, F. Kallinowski, S. Walenta, 1988, Cancer research.

Splenic blood flow and intrasplenic flow distribution in rats

P. Vaupel, H. Hutten, H. Ruppert, 1977, Pflügers Archiv.

Accumulation of purine catabolites in solid tumors exposed to therapeutic hyperthermia

P. Vaupel, M. Busse, 1996, Experientia.

Effects of hyperthermia on normal and tumor microenvironment.

P Vaupel, H I Bicher, F. Hetzel, 1980, Radiology.

pH distributions in spontaneous and isotransplanted rat tumours.

P. Vaupel, F. Kallinowski, 1988, British Journal of Cancer.

Hypoxia in neoplastic tissue.

P. Vaupel, 1977, Microvascular research.

Tumor microenvironmental physiology and its implications for radiation oncology.

Peter Vaupel, P. Vaupel, 2004, Seminars in radiation oncology.

Availability, not respiratory capacity governs oxygen consumption of solid tumors.

P. Vaupel, A. Mayer, 2012, The international journal of biochemistry & cell biology.

Stress Response Leading to Resistance in Glioblastoma—The Need for Innovative Radiotherapy (iRT) Concepts

P. Vaupel, S. Combs, G. Multhoff, 2016, Cancers.

Blood flow and metabolic microenvironment of brain tumors

P. Vaupel, P. Vaupel, 2005, Journal of Neuro-Oncology.

Lack of hypoxic response in uterine leiomyomas despite severe tissue hypoxia.

A. Wree, P. Vaupel, L. Horn, 2008, Cancer research.

Acute versus chronic hypoxia in tumors

P. Vaupel, P. Vaupel, C. Bayer, 2012, Strahlentherapie und Onkologie.

The role of hypoxia-induced factors in tumor progression.

Peter Vaupel, P. Vaupel, 2004, The oncologist.

Differential expression of HIF-1 in glioblastoma multiforme and anaplastic astrocytoma

C. Sommer, P. Vaupel, A. Mayer, 2012, International journal of oncology.

Heterogeneity in tissue oxygenation: from physiological variability in normal tissues to pathophysiological chaos in malignant tumours.

David K Harrison, Peter Vaupel, P. Vaupel, 2014, Advances in experimental medicine and biology.

Radiochemotherapy combined with NK cell transfer followed by second-line PD-1 inhibition in a patient with NSCLC stage IIIb inducing long-term tumor control: a case study

P. Vaupel, G. Multhoff, S. Stangl, 2019, Strahlentherapie und Onkologie.

GLUT-1 expression is largely unrelated to both hypoxia and the Warburg phenotype in squamous cell carcinomas of the vulva

P. Vaupel, Marcus Schmidt, A. Mayer, 2014, BMC Cancer.

Hypoxia Compromises Anti-Cancer Immune Responses.

P. Vaupel, G. Multhoff, 2020, Advances in experimental medicine and biology.

Tumor hypoxia and malignant progression.

P. Vaupel, M. Höckel, A. Mayer, 2009, Methods in enzymology.

Hypoxia in breast cancer: pathogenesis, characterization and biological/therapeutic implications.

P. Vaupel, S. Briest, M. Höckel, 2002, Wiener medizinische Wochenschrift.

Biological consequences of tumor hypoxia.

P Vaupel, P. Vaupel, M. Höckel, 2001, Seminars in oncology.

Hypoxia and anemia: effects on tumor biology and treatment resistance.

P. Vaupel, A. Mayer, 2005, Transfusion clinique et biologique : journal de la Societe francaise de transfusion sanguine.

Treatment resistance of solid tumors

Oliver Thews, Peter Vaupel, P. Vaupel, 2001 .

Blood Perfusion and Microenvironment of Human Tumors

Peter Vaupel, M. Molls, P. Vaupel, 2000 .

Endogenous hypoxia markers: case not proven!

Michael Höckel, Peter Vaupel, P. Vaupel, 2008, Advances in experimental medicine and biology.

Endogenous Hypoxia Markers in Locally Advanced Cancers of the Uterine Cervix: Reality or Wishful Thinking?

P. Vaupel, M. Höckel, A. Mayer, 2006, Strahlentherapie und Onkologie.

Heterogeneous oxygenation of rectal carcinomas in humans: a critical parameter for preoperative irradiation?

P. Vaupel, G. Thews, R. Manz, 1984, Advances in experimental medicine and biology.

The Impact of the Tumor Microenvironment on Experimental and Clinical Radiation Oncology and Other Therapeutic Modalities

M. Molls, P. Vaupel, M. Molls, 2000 .

Lacking hypoxia-mediated downregulation of E-cadherin in cancers of the uterine cervix

P. Vaupel, L. Horn, M. Höckel, 2013, British Journal of Cancer.

Hypoxia in breast cancer: role of blood flow, oxygen diffusion distances, and anemia in the development of oxygen depletion.

Michael Höckel, Susanne Briest, Peter Vaupel, 2005, Advances in experimental medicine and biology.

Angiogenesis of uterine cervical carcinoma: characterization by pharmacokinetic magnetic resonance parameters and histological microvessel density with correlation to lymphatic involvement.

G Brix, M V Knopp, P Vaupel, 1997, Cancer research.

Microenvironmental adaptation of experimental tumours to chronic vs acute hypoxia

P. Vaupel, O. Thews, D. Kelleher, 2004, British Journal of Cancer.

Cervical carcinoma: standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival.

M. Knopp, P. Vaupel, H. Hawighorst, 1999 .

Oxygenation Status of Gynecologic Tumors: What is the Optimal Hemoglobin Level?

Oliver Thews, Michael Höckel, Peter Vaupel, 2002, Strahlentherapie und Onkologie.

Impact of Hemoglobin Levels on Tumor Oxygenation: the Higher, the Better?

Michael Höckel, Peter Vaupel, P. Vaupel, 2006, Strahlentherapie und Onkologie.

The Warburg effect: essential part of metabolic reprogramming and central contributor to cancer progression

Peter Vaupel, P. Vaupel, A. Mayer, 2019, International journal of radiation biology.

Effect of injectable or inhalational anesthetics and of neuroleptic, neuroleptanalgesic, and sedative agents on tumor blood flow.

P. Vaupel, H. Menke, 1988, Radiation research.

Circulatory and metabolic responses of malignant tumors during localized hyperthermia

P. Vaupel, W. Müller-Klieser, K. Ostheimer, 2004, Journal of Cancer Research and Clinical Oncology.

Tumor tissue oxygenation as evaluated by computerized-pO2-histography.

P. Vaupel, M. Hoeckel, F. Kallinowski, 1990, International journal of radiation oncology, biology, physics.

Blood flow, oxygen consumption, and tissue oxygenation of human breast cancer xenografts in nude rats.

P Vaupel, P. Vaupel, F. Kallinowski, 1987, Cancer research.

Nifedipine improves blood flow and oxygen supply, but not steady-state oxygenation of tumours in perfusion pressure-controlled isolated limb perfusion

P. Vaupel, O. Thews, D. Kelleher, 2002, British Journal of Cancer.

Disparate responses of tumour vessels to angiotensin II: tumour volume-dependent effects on perfusion and oxygenation

P. Vaupel, O. Thews, D. Kelleher, 2000, British Journal of Cancer.

Clinical Investigations on Blood Perfusion in Human Tumors

P. Vaupel, H. Feldmann, M. Molls, 2000 .

Improvement of tumor spheroid oxygenation by tetrachlorodecaoxide.

P. Vaupel, W. Mueller‐Klieser, 1987, International journal of radiation oncology, biology, physics.

Tetrachlorodecaoxide improves the oxygenation status of multicellular tumor spheroids.

P. Vaupel, W. Mueller‐Klieser, 1986, Advances in experimental medicine and biology.

Is tissue hypoxia the principle mechanism for immune evasion and malignant progression in Hepatocellular Carcinoma?

P. Vaupel, T. Cramer, 2021, Journal of hepatology.

Hypoxic cervical cancers with low apoptotic index are highly aggressive.

P. Vaupel, M. Höckel, K. Schlenger, 1999, Cancer research.

Advances in Brief In Vivo Oxygen Consumption Rate of DS Sarcoma Cells on Inhibition of DNA Synthesis 1

P. Vaupel, O. Thews, D. Kelleher, 2006 .

In vivo oxygen consumption rate of DS sarcoma cells on inhibition of DNA synthesis.

P. Vaupel, O. Thews, D. Kelleher, 1996, Cancer research.

Tumor oxygenation and its relevance to tumor physiology and treatment.

Michael Höckel, Peter Vaupel, P. Vaupel, 2003, Advances in experimental medicine and biology.

Pathophysiological and Vascular Characteristics of Solid Tumors in Relation to Drug Delivery

P. Vaupel, 2011 .

Physiological Mechanisms of Treatment Resistance

P. Vaupel, 2009 .

Tumor hypoxia and therapeutic resistance

P. Vaupel, M. Höckel, 2008 .

Oxygen Deprivation Modulates EGFR and PD-L1 in Squamous Cell Carcinomas of the Head and Neck

P. Vaupel, G. Multhoff, A. Mayer, 2021, Frontiers in Oncology.

Biophysical and photobiological basics of water-filtered infrared-A hyperthermia of superficial tumors

P. Vaupel, H. Piazena, M. Notter, 2018, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Critical Role of Aberrant Angiogenesis in the Development of Tumor Hypoxia and Associated Radioresistance

P. Vaupel, G. Multhoff, J. Radons, 2014, Cancers.

Impact of therapeutically induced reactive oxygen species and radical scavenging by alpha-tocopherol on tumor cell adhesion.

P. Vaupel, O. Thews, D. Kelleher, 2007, Oncology reports.

Comment on Kronenfeld et al. Clinical Outcomes for Primary and Radiation-Associated Angiosarcoma of the Breast with Multimodal Treatment: Long-Term Survival Is Achievable. Cancers 2021, 13, 3814

P. Vaupel, A. Kollár, A. Thomsen, 2021, Cancers.

Treatment resistance of solid tumors: role of hypoxia and anemia.

P. Vaupel, O. Thews, M. Hoeckel, 2001, Medical oncology.

Intratumoral pO2 histography as predictive assay in advanced cancer of the uterine cervix.

P Vaupel, P. Vaupel, M. Höckel, 1994, Advances in experimental medicine and biology.

Integrating Hyperthermia into Modern Radiation Oncology: What Evidence Is Necessary?

P. Vaupel, S. Combs, J. Peeken, 2017, Front. Oncol..

Enhancement of Oxidative Cell Injury and Antitumor Effects of Localized 44Â°C Hyperthermia upon Combination with Respiratory Hyperoxia and

P. Vaupel, O. Thews, D. Kelleher, 1998 .

Erythropoietin restores the anemia-induced reduction in cyclophosphamide cytotoxicity in rat tumors.

P Vaupel, O Thews, P. Vaupel, 2001, Cancer research.

Recombinant human erythropoietin increases the radiosensitivity of xenografted human tumours in anaemic nude mice

P. Vaupel, O. Thews, M. Stuschke, 2001, Journal of Cancer Research and Clinical Oncology.

Pathophysiological and vascular characteristics of tumours and their importance for hyperthermia: Heterogeneity is the key issue

P. Vaupel, D. Kelleher, 2010, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Metabolic Status and Reaction to Heat of Normal and Tumor Tissue

P. Vaupel, D. Kelleher, 1995 .

Physiological properties of malignant tumours

P. Vaupel, 1992, NMR in biomedicine.

Temporal changes in tumor oxygenation and perfusion upon normo- and hyperbaric inspiratory hyperoxia

P. Vaupel, O. Thews, 2016, Strahlentherapie und Onkologie.

Evaluation of oxygen diffusion distances in human breast cancer using cell line specific in vivo data: role of various pathogenetic mechanisms in the development of tumor hypoxia.

P. Vaupel, F. Kallinowski, K. Groebe, 1988, Advances in experimental medicine and biology.

Hyperthermia and hyperglycemia for manipulated inhibition of tumor microcirculation

P. Vaupel, W. Müller-Klieser, H. Gabbert, 2004, Journal of Cancer Research and Clinical Oncology.

Pathophysiology of tumors in hyperthermia.

P. Vaupel, F. Kallinowski, M. Kluge, 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Modern Radiation Oncology: what evidence is Necessary?

P. Vaupel, S. Combs, J. Peeken, 2017 .

Isolated Hyperthermic Limb Perfusion

P. Vaupel, C. Alexander, G. Omlor, 1995 .

Fatal Alliance of Hypoxia-/HIF-1α-Driven Microenvironmental Traits Promoting Cancer Progression.

P. Vaupel, G. Multhoff, 2020, Advances in experimental medicine and biology.

TISSUE OXYGENATION AND NORMAL AND HYPERTHERMIC CONDITIONS

P. Vaupel, H. Bicher, M. O'Hara, 1981 .

Human Tumor Xenografts in Nude Rats: A New Model for the Study of Tumor Pathophysiology

P. Vaupel, F. Kallinowski, G. Bastert, 1987 .

Induction of dormancy in hypoxic human papillomavirus-positive cancer cells

P. Vaupel, F. Rösl, F. Hoppe-Seyler, 2017, Proceedings of the National Academy of Sciences.

Hypoxia, lactate accumulation, and acidosis: siblings or accomplices driving tumor progression and resistance to therapy?

Peter Vaupel, P. Vaupel, A. Mayer, 2013, Advances in experimental medicine and biology.

Blood flow and tissue oxygenation of human tumors: an update.

P Vaupel, P. Vaupel, M. Hoeckel, 1992, Advances in experimental medicine and biology.

Vascularity, perfusion rate and local tissue oxygenation of tumors derived from rus‐transformed fibroblasts

P. Vaupel, W. Strauss, R. Moore, 2007, International journal of cancer.

Combined tissue oxygen tension measurement and positron emission tomography studies on glucose utilization in oncogene-transformed cell line tumour xenografts in nude mice.

P. Vaupel, G. Brownell, A. Brownell, 1991, The British journal of radiology.

Lack of association between tumor oxygenation and cell cycle distribution or proliferation kinetics in experimental sarcomas.

P. Vaupel, O. Thews, D. Kelleher, 2003, Advances in experimental medicine and biology.

[Influence of increased arterial CO2 pressures on oxygen and glucose uptake of DS-carcinosarcoma in vivo].

P. Vaupel, J. Grote, H. Günther, 1971, Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.

Pathophysiological Basis for the Formation of the Tumor Microenvironment

P. Vaupel, M. Horsman, 2016, Front. Oncol..

Purified monocyte-derived angiogenic substance (angiotropin) induces controlled angiogenesis associated with regulated tissue proliferation in rabbit skin.

P. Vaupel, W. Jung, H. Rabes, 1988, The Journal of clinical investigation.

Vascularization, blood flow, oxygenation, tissue pH, and bioenergetic status of human breast cancer.

P Vaupel, P. Vaupel, 1997, Advances in experimental medicine and biology.

Tumor hypoxia in pelvic recurrences of cervical cancer

P. Vaupel, M. Höckel, K. Schlenger, 1998, International journal of cancer.

Oxygenation gain factor: a novel parameter characterizing the association between hemoglobin level and the oxygenation status of breast cancers.

Michael Höckel, Susanne Briest, Peter Vaupel, 2003, Cancer research.

Localized hypothermia: impact on oxygenation, microregional perfusion, metabolic and bioenergetic status of subcutaneous rat tumours.

P. Vaupel, O. Thews, D. Kelleher, 1998, British Journal of Cancer.

Erythropoietin: effects on life expectancy in patients with cancer-related anaemia

P. Vaupel, M. Aapro, 2006 .

P. Vaupel, F. Kallinowski, W. Mueller‐Klieser, 1989, Journal of cellular physiology.

[Respiratory gas exchange and glucose uptake by the human spleen in situ (author's transl)].

P. Vaupel, P. Wendling, H. Thome, 1977, Klinische Wochenschrift.

Hypoxia in tumors: pathogenesis-related classification, characterization of hypoxia subtypes, and associated biological and clinical implications.

Peter Vaupel, P. Vaupel, A. Mayer, 2014, Advances in experimental medicine and biology.

Oxygen tension distributions are sufficient to explain the local response of human breast tumors treated with radiation alone.

P Okunieff, P Vaupel, P. Okunieff, 1993, International journal of radiation oncology, biology, physics.

Human anatomy, physiology, and pathophysiology

Ernst Mutschler, G. Thews, P. Vaupel, 1985 .

Glucose metabolism of malignant cells is not regulated by transketolase-like (TKTL)-1.

P. Vaupel, A. von Wallbrunn, A. Mayer, 2010, International journal of oncology.

Splenic respiratory gas exchange and glucose uptake in patients with splenomegaly in hypersplenism and hodgkin's disease

P. Vaupel, P. Wendling, P. Wendling, 1977, Klinische Wochenschrift.

Intratumoral pO 2 predicts survival in advanced cancer of the uterine cervix

P. Vaupel, M. Mitze, M. Hockel, 2003 .

Pathophysiological Barriers Impeding the Delivery of Heat Shock Protein (HSP)-Based Macromolecules and Nanotherapeutics to Solid Tumors

P. Vaupel, G. Multhoff, 2012 .

Biological validation of electron paramagnetic resonance (EPR) image oxygen thresholds in tissue

P. Vaupel, H. Halpern, M. Giurcanu, 2020, The Journal of Physiology.

Intensified oxidative and nitrosative stress following combined ALA‐based photodynamic therapy and local hyperthermia in rat tumors

P. Vaupel, O. Thews, D. Kelleher, 2003, International journal of cancer.

Impact of oxygenation status and patient age on DNA content in cancers of the uterine cervix.

P. Vaupel, O. Thews, M. Höckel, 2003, International journal of radiation oncology, biology, physics.

Blood flow and associated pathophysiology of uterine cervix cancers: Characterisation and relevance for localised hyperthermia

P. Vaupel, D. Kelleher, 2012, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Expression pattern of the urokinase-plasminogen activator system in rat DS-sarcoma: Role of oxygenation status and tumour size

P. Vaupel, O. Thews, M. Weinmann, 2002, British Journal of Cancer.

Nicotinamide exerts different acute effects on microcirculatory function and tissue oxygenation in rat tumors.

P. Vaupel, D. Kelleher, D K Kelleher, 1993, International journal of radiation oncology, biology, physics.

Dose-dependent effects of hydralazine on microcirculatory function and hyperthermic response of murine FSall tumors.

P. Okunieff, P. Vaupel, J. Kalmus, 1990, Cancer research.

Effect of Various Calcium Antagonists on Blood Flow and Red Blood Cell Flux in Malignant Tumors

P. Vaupel, H. Menke, 1988 .

TNF alpha primes polymorphonuclear leukocytes for an enhanced respiratory burst to a similar extent as bacterial lipopolysaccharide.

P. Vaupel, F. Kallinowski, R. Schopf, 1990, The Journal of investigative dermatology.

Metabolic imaging in microregions of tumors and normal tissues with bioluminescence and photon counting.

W. Paschen, P. Vaupel, F. Kallinowski, 1988, Journal of the National Cancer Institute.

The role of tumor volume in 'reoxygenation' upon cyclophosphamide treatment.

P. Vaupel, M. Busse, 1995, Acta oncologica.

Uterine cervical carcinoma: comparison of standard and pharmacokinetic analysis of time-intensity curves for assessment of tumor angiogenesis and patient survival.

G Brix, M V Knopp, P Vaupel, 1998, Cancer research.

Measurements of tumor blood flow using intraperitoneal deuterium and 2H-NMR spectroscopy.

P. Okunieff, P. Vaupel, J. Lee, 1992, Advances in experimental medicine and biology.

Lactate-avid regulatory T cells: metabolic plasticity controls immunosuppression in tumour microenvironment

P. Vaupel, G. Multhoff, 2021, Signal Transduction and Targeted Therapy.

'Oxygen Level in a Tissue' - What Do Available Measurements Really Report?

P Vaupel, A. Flood, P. Vaupel, 2020, Advances in experimental medicine and biology.

The Warburg Effect: Historical Dogma Versus Current Rationale.

P. Vaupel, G. Multhoff, 2021, Advances in experimental medicine and biology.

Oxygen transport in tumors: characteristics and clinical implications.

P. Vaupel, 1996, Advances in Experimental Medicine and Biology.

Tumor Hypoxia: Causative Mechanisms, Microregional Heterogeneities, and the Role of Tissue-Based Hypoxia Markers.

Peter Vaupel, P. Vaupel, A. Mayer, 2016, Advances in experimental medicine and biology.

Red Cell Interactions with the Microcirculation

S. Chien, J. Whaun, P. Gaehtgens, 1976 .

Pyruvate kinase and the interaction of amino acid and carbohydrate metabolism in solid tumors.

M. Ott, P. Vaupel, F. Kallinowski, 1998, Anticancer research.

Tumor blood flow: The principal modulator of oxidative and glycolytic metabolism, and of the metabolic micromilieu of human tumor xenografts in vivo

P. Vaupel, F. Kallinowski, M. Stohrer, 1989, International journal of cancer.

Oxygen diffusivity in tumor tissue (DS-Carcinosarcoma) under temperature conditions within the range of 20–40°C

P. Vaupel, J. Grote, J. Grote, 1977, Pflügers Archiv.

The influence of tumor blood flow and microenvironmental factors on the efficacy of radiation, drugs and localized hyperthermia

P. Vaupel, P W Vaupel, 1997, Klinische Padiatrie.

Effects of Recombinant Human Erythropoietin (rHuEPO) on Tumor Control in Patients with Cancer-Induced Anemia

P. Vaupel, J. Dunst, W. Jelkmann, 2005, Oncology Research and Treatment.

Blood supply, oxygenation status and metabolic micromilieu of breast cancers: characterization and therapeutic relevance.

P. Vaupel, M. Hockel, M. Höckel, 2000, International journal of oncology.

Tumor oxygenation in anemic rats: effects of erythropoietin treatment versus red blood cell transfusion.

P. Vaupel, O. Thews, D. Kelleher, 1995, Acta oncologica.

Oxygenation of human tumors.

P Vaupel, P. Vaupel, 1990, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

Tumour tissue monitoring during photodynamic and hyperthermic treatment using bioimpedance spectroscopy.

P. Vaupel, D. Kelleher, E. Gersing, 2003, Physiological measurement.

Hypoxia-stimulated expression of angiogenic growth factors in cervical cancer cells and cervical cancer-derived fibroblasts

P. Vaupel, E. Steiner, H. Pilch, 2001, International Journal of Gynecologic Cancer.

Clinical and Statistical Considerations when Assessing Oxygen Levels in Tumors: Illustrative Results from Clinical EPR Oximetry Studies.

P Vaupel, T Liu, A. Flood, 2020, Advances in experimental medicine and biology.

Hyperthermia Plus Re-Irradiation in the Management of Unresectable Locoregional Recurrence of Breast Cancer in Previously Irradiated Sites.

P. Vaupel, A. Grosu, A. Thomsen, 2020, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Blood flow and oxygenation status of prostate cancers.

Peter Vaupel, P. Vaupel, D. Kelleher, 2013, Advances in experimental medicine and biology.

Downregulation of EGFR in hypoxic, diffusion-limited areas of squamous cell carcinomas of the head and neck

P. Vaupel, J. Brieger, A. Mayer, 2016, British Journal of Cancer.

2-Methoxyestradiol enhances reactive oxygen species formation and increases the efficacy of oxygen radical generating tumor treatment.

P. Vaupel, O. Thews, D. Kelleher, 2002, European journal of medical research.

In vivo 31P-NMR spectroscopy of murine tumours before and after localized hyperthermia.

P. Okunieff, P. Vaupel, L. Neuringer, 1990, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Combined wIRA-Hyperthermia and Hypofractionated Re-Irradiation in the Treatment of Locally Recurrent Breast Cancer: Evaluation of Therapeutic Outcome Based on a Novel Size Classification

P. Vaupel, A. Grosu, R. Hermann, 2020, Cancers.

Spatial oxygenation profiles in tumors during normo- and hyperbaric hyperoxia

P. Vaupel, O. Thews, 2015, Strahlentherapie und Onkologie (Print).

Blood flow, oxygen consumption and tissue oxygenation of human tumors.

P Okunieff, P Vaupel, P. Okunieff, 1990, Advances in experimental medicine and biology.

How best to interpret measures of levels of oxygen in tissues to make them effective clinical tools for care of patients with cancer and other oxygen‐dependent pathologies

Harold M. Swartz, Howard Halpern, Brian W. Pogue, 2020, Physiological reports.

The effect of nicotinamide on microcirculatory function, tissue oxygenation and bioenergetic status in rat tumors.

P. Vaupel, D. Kelleher, 1994, Advances in experimental medicine and biology.

Intracapillary HbO2 saturation in malignant tumors during normoxia and hyperoxia.

P. Vaupel, W. Müller-Klieser, W. Grunewald, 1979, Microvascular research.

Proposal for using a standardized terminology on oxygen transport to tissue.

R Zander, P Vaupel, P. Vaupel, 1985, Advances in experimental medicine and biology.

Vascular Meets of Localized Hyperthermia

P. Vaupel, D. Kelleher, 2006 .

Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists

Stephanie E. Combs, Gabriele Multhoff, Jan J. Wilkens, 2017, Front. Oncol..

Blood flow and oxygenation status of human tumors

P. Vaupel, H. Feldmann, M. Molls, 1999, Coloproctology.

Predictive power of the tumor oxygenation status.

P. Vaupel, M. Hoeckel, 1999, Advances in experimental medicine and biology.

Radiosensitization of Normoxic and Hypoxic H1339 Lung Tumor Cells by Heat Shock Protein 90 Inhibition Is Independent of Hypoxia Inducible Factor-1α

M. Molls, P. Vaupel, Wei Li, 2012, PloS one.

Grußwort / Abstracts

P. Vaupel, M. Höckel, K. Haake, 2001, Oncology Research and Treatment.

Oxygenation of malignant tumors after localized microwave hyperthermia

P. Vaupel, Johannes Otte, Rolf Manz, 1982, Radiation and environmental biophysics.

Computer-assisted interpretation of flow cytometry data in hematology.

P Vaupel, O Thews, P. Vaupel, 1996, Cytometry.

Oxygen Transport to Tissue XVIII

Chris E. Cooper, David F. Wilson, Thomas K. Hunt, 2012, Advances in Experimental Medicine and Biology.

Is there a critical tissue oxygen tension for bioenergetic status and cellular pH regulation in solid tumors?

P. Vaupel, 1996, Experientia.

Intracellular acidosis in murine fibrosarcomas coincides with ATP depletion, hypoxia, and high levels of lactate and total Pi

P. Okunieff, P. Vaupel, C. Schaefer, 1994, NMR in biomedicine.

Oxygenation and bioenergetic status of murine fibrosarcomas.

P. Okunieff, P. Vaupel, C. Schaefer, 1992, Advances in experimental medicine and biology.

Pathophysiological approaches to identifying tumor hypoxia in patients.

P Vaupel, P. Vaupel, M. Hoeckel, 1991, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Impact of reactive oxygen species on the expression of adhesion molecules in vivo.

P. Vaupel, O. Thews, D. Kelleher, 2009, Advances in experimental medicine and biology.

Concurrent measurements of O2 partial pressures and pH values in human mammary carcinoma xenotransplants.

P. Vaupel, F. Kallinowski, 1986, Advances in experimental medicine and biology.

Human mammary carcinomas in nude rats--a new approach for investigating oxygen transport and substrate utilization in tumor tissues.

P. Vaupel, F. Kallinowski, H. Gabbert, 1985, Advances in experimental medicine and biology.

Direct measurement of reoxygenation in malignant mammary tumors after a single large dose of irradiation.

P. Vaupel, S. Frinak, M. O'Hara, 1984, Advances in experimental medicine and biology.

Changes in microregional perfusion, oxygenation, ATP and lactate distribution in subcutaneous rat tumours upon water-filtered IR-A hyperthermia.

P. Vaupel, D. Kelleher, D K Kelleher, 1995, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Can tumor oxygenation be improved by reducing cellular oxygen consumption.

P. Vaupel, O. Thews, D. Kelleher, 1999, Advances in experimental medicine and biology.

Effect of cell line and differentiation on the oxygenation status of experimental sarcomas.

P Vaupel, O Thews, P. Vaupel, 1997, Advances in experimental medicine and biology.

Measurement of human tumor blood flow: a positron technique using an artifact of high energy radiation therapy.

P. Okunieff, P. Vaupel, P. Okunieff, 1992, Advances in experimental medicine and biology.

From Localized Mild Hyperthermia to Improved Tumor Oxygenation: Physiological Mechanisms Critically Involved in Oncologic Thermo-Radio-Immunotherapy

F. Scholkmann, P. Vaupel, A. Grosu, 2023, Cancers.

Quantitative changes of metabolic and bioenergetic parameters in experimental tumors during fractionated irradiation.

P Vaupel, O Thews, P. Vaupel, 1999, International journal of radiation oncology, biology, physics.

GLUT-1 staining of squamous cell carcinomas of the uterine cervix identifies a novel element of invasion.

P. Vaupel, L. Horn, M. Höckel, 2010, International journal of oncology.

Perfusion, oxygenation status and growth of experimental tumors upon photodynamic therapy with Pd-bacteriopheophorbide.

A. Scherz, P. Vaupel, O. Thews, 2004, International journal of oncology.

Combined hyperthermia and chlorophyll-based photodynamic therapy: tumour growth and metabolic microenvironment

A. Scherz, P. Vaupel, O. Thews, 2003, British Journal of Cancer.

Changes in perfusion pattern of experimental tumors due to reduction in arterial oxygen partial pressure.

P. Vaupel, O. Thews, D. Kelleher, 2006, Advances in experimental medicine and biology.

Microcirculatory function, tissue oxygenation, microregional redox status and ATP distribution in tumors upon localized infrared-A-hyperthermia at 42 degrees C.

B. Chance, P. Vaupel, O. Thews, 2003, Advances in experimental medicine and biology.

Dynamics of tumor oxygenation and red blood cell flux in response to inspiratory hyperoxia combined with different levels of inspiratory hypercapnia.

P. Vaupel, O. Thews, D. Kelleher, 2002, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

Water-filtered infrared-A radiation: a novel technique for localized hyperthermia in combination with bacteriochlorophyll-based photodynamic therapy.

A. Scherz, P. Vaupel, O. Thews, 1999, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[Respiratory gas exchange and glucose metabolism of tumors (DS-carcinosarcoma) in vivo. I. Experimental investigations of the parameters determining the supply conditions].

P. Vaupel, J. Grote, G. Aumüller, 1971, Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimentelle Chirurgie.

Respiratory Gas Transport in Brain under Normal and Pathological Conditions

P. Vaupel, H. Reulen, J. Grote, 1973 .

[PO-2-PCO-2-pH-nomograms for rat blood at 37 degrees C (author's transl)].

P. Vaupel, G. Thews, R. Bork, 1975, Der Anaesthesist.

[Effect of hyperglycemia on oxygen and glucose uptake of implanted tumors (DS-carcinosarcoma) in vivo].

P. Vaupel, J. Grote, H. Günther, 1972, Zeitschrift fur Krebsforschung und klinische Onkologie. Cancer research and clinical oncology.

Respiratory gas exchange in the rat spleen in situ and intrasplenic oxyhemoglobin saturation

P. Vaupel, W. Müller-Klieser, R. Manz, 1979, Pflügers Archiv.

O2 supply conditions in tumor tissue in vivo.

P. Vaupel, G. Thews, 1976, Advances in experimental medicine and biology.

wIRA-heating of piglet skin and subcutis in vivo: proof of accordance with ESHO criteria for superficial hyperthermia

P. Vaupel, H. Piazena, Werner Müller, 2020, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Thermal field formation during wIRA-hyperthermia: temperature measurements in skin and subcutis of piglets as a basis for thermotherapy of superficial tumors and local skin infections caused by thermosensitive microbial pathogens

P. Vaupel, G. Pluschke, H. Piazena, 2019, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

[Water-filtered infrared-A-hyperthermia combined with radiotherapy in advanced and recurrent tumors. Initial results of a multicenter phase I-II study].

P. Vaupel, H. Feldmann, M. Stuschke, 1996, Strahlentherapie und Onkologie (Print).

Water-filtered infrared-A radiation: a novel technique to heat superficial tumors.

P. Vaupel, D. Kelleher, W. Krüger, 1992, Strahlentherapie und Onkologie : Organ der Deutschen Rontgengesellschaft ... [et al].

Problems involved in temperature measurements using EIT.

E Gersing, P Vaupel, P. Vaupel, 1995, Physiological measurement.

O2 extraction is a key parameter determining the oxygenation status of malignant tumors and normal tissues

P. Vaupel, O. Thews, D. Kelleher, 2003 .

Oxygenation status of primary and recurrent squamous cell carcinomas of the vulva.

P Vaupel, P. Vaupel, M. Höckel, 2006, European journal of gynaecological oncology.

Lactate-induced inhibition of tumor cell proliferation.

P Vaupel, P. Vaupel, W. Mueller‐Klieser, 1988, International journal of radiation oncology, biology, physics.

Oxygen Transport in Tumors

P. Vaupel, 1996 .

Multiparametric Analysis of the Tumor Microenvironment: Hypoxia Markers and Beyond.

P. Vaupel, A. Mayer, 2017, Advances in experimental medicine and biology.

Critical O2 and glucose supply and microcirculation in tumor tissue.

P. Vaupel, G. Thews, V. Schulz, 1973, Bibliotheca anatomica.

Hypoxia and Radiation Response in Human Tumors.

P. Vaupel, M. Mitze, K. Schlenger, 1996, Seminars in radiation oncology.

Dose-dependent Effects of Hydralazine on Microcirculatory Function and Hyperthermic Response of Murine FSall Tumors1

P. Okunieff, P. Vaupel, Kalmus, 2006 .

Regional perfusion and oxygenation of tumors upon methylxanthine derivative administration.

P Vaupel, O Thews, P. Vaupel, 1998, International journal of radiation oncology, biology, physics.

The Splanchnic Circulation

C. Zarins, P. Vaupel, H. Hutten, 1976 .

Pyruvate kinase type M2: a crossroad in the tumor metabolome

P. Vaupel, C. Boschek, S. Mazurek, 2002, British Journal of Nutrition.

Oxygenation of human tumors: evaluation of tissue oxygen distribution in breast cancers by computerized O2 tension measurements.

P. Vaupel, K. Schlenger, C. Knoop, 1991, Cancer research.

Erythropoiesis-Stimulating Agents: Favorable Safety Profile When Used as Indicated

P. Vaupel, J. Dunst, M. Nowrousian, 2008, Strahlentherapie und Onkologie.

Pathophysiological aspects of hyperthermia

P. Vaupel, 1992, Acta Chirurgica Austriaca.

[Impact of localized microwave hyperthermia on the pH-distribution in malignant tumors (author's transl)].

P. Vaupel, 1982, Strahlentherapie.

Recommendations for using the standardized terminology of respiratory physiology in radiation research.

P. Vaupel, R. Sutherland, W. Mueller‐Klieser, 1983, Radiation research.

Flow — Resistance Relationship for the Cerebrovascular System of Rabbits under Normal and Pathophysiological Conditions

P. Vaupel, H. Hutten, 1980 .

[Effect of bencyclane on the cerebral vascular resistance in normal and impaired acid-base status].

P. Vaupel, H. Hutten, 1977, Die Medizinische Welt.

In vivo investigations on microcirculatory disturbances induced by crenated erythrocytes following norepinephrine application

P. Vaupel, P. Wendling, 1974, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

[Critical oxygen and glucose supply of malignant tumors].

P. Vaupel, G. Thews, P. Wendling, 1976, Deutsche medizinische Wochenschrift.

[The oxygen supply of the kidney. I. Distribution of O2 partial pressures in the rat kidney under normal conditions (author's transl)].

P. Vaupel, G. Aumüller, G. Thews, 1974, Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie.

Erythropoietin to treat anaemia in patients with head and neck cancer

P. Vaupel, A. Mayer, 2004, The Lancet.

MICROCIRCULATION MODIFICATIONS BY LOCALIZED MICROWAVE HYPERTHERMIA AND HEMATOPORPHYRIN PHOTOTHERAPY

F. Hetzel, P. Vaupel, H. Bicher, 2015 .

Availability, not respiratory capacity governs oxygen consumption of solid tumors.

P. Vaupel, A. Mayer, 2012, The international journal of biochemistry & cell biology.