N. Bleehen

N. Bleehen, D. Hu, D. Honess, 1991, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

BW12C: effects on tumour hypoxia, tumour thermosensitivity and relative tumour and normal tissue perfusion in C3H mice.

N. Bleehen, D. Hu, D. Honess, 1991, British Journal of Cancer.

A phase I study of intravenous RMP-7 with carboplatin in patients with progression of malignant glioma.

N. Bleehen, T. Barton, C. Osborn, 1998, European journal of cancer.

Phase I study of BW12C in combination with mitomycin C in patients with advanced gastrointestinal cancer.

N. Bleehen, P. Workman, J. Ramsay, 1992, International journal of radiation oncology, biology, physics.

Survival, adverse reactions and quality of life during combination chemotherapy compared with selective palliative treatment for small-cell lung cancer. Report to the Medical Research Council by its Lung Cancer Working Party.

P. Fayers, D. Girling, R. Stephens, 1989, Respiratory medicine.

Controlled trial of twelve versus six courses of chemotherapy in the treatment of small-cell lung cancer. Report to the Medical Research Council by its Lung Cancer Working Party.

P. Fayers, D. Girling, R. Stephens, 1989, British Journal of Cancer.

A phase I study of the combination of benznidazole and CCNU in man.

N. Bleehen, P. Workman, M. Walton, 1984, International journal of radiation oncology, biology, physics.

Does initial haemoglobin level modify the efficacy of radiosensitizers? An analysis of the MRC misonidazole studies in head and neck cancer and cervix cancer.

N. Bleehen, G. Adams, S. Dische, 1987, International journal of radiation biology and related studies in physics, chemistry, and medicine.

Nicotinamide and pentoxifylline increase human leucocyte filterability: a possible mechanism for reduction of acute hypoxia.

N. Bleehen, D. Honess, Y. Kitamoto, 1996, The British journal of cancer. Supplement.

Measurements of resting energy expenditure and body composition before and after treatment of small cell lung cancer.

M. Elia, N. Bleehen, A. Dixon, 1994, Annals of oncology : official journal of the European Society for Medical Oncology.

The multi-dose clinical tolerance and pharmacokinetics of the combined radiosensitizers, Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).

N. Bleehen, P. Workman, R. Ward, 1988, International journal of radiation oncology, biology, physics.

The in vitro effects and cross-resistance patterns of some novel anthracyclines.

N. Bleehen, P. Workman, N. Fox, 1986, British Journal of Cancer.

Hypoxic cell radiosensitizers in the treatment of high grade gliomas: a new direction using combined Ro 03-8799 (pimonidazole) and SR 2508 (etanidazole).

N. Bleehen, P. Workman, R. Ward, 1988, International journal of radiation oncology, biology, physics.

A phase I study of the hypoxic cell radiosensitizer Ro-03-8799.

N. Bleehen, P. Workman, M. Walton, 1984, International journal of radiation oncology, biology, physics.

Stimulation by localized tumor hyperthermia of reductive bioactivation of 2-nitroimidazole benznidazole in mice.

N. Bleehen, P. Workman, M. Walton, 1989, Cancer research.

Heat-stimulated nitroreductive bioactivation of the 2-nitroimidazole benznidazole in vitro.

N. Bleehen, P. Workman, M. Walton, 1987, Biochemical pharmacology.

Oestrogen potentiates topoisomerase‐II‐mediated cytotoxicity in an activated subpopulation of human breast cancer cells: Implications for cytotoxic drug resistance in solid tumours

N. Bleehen, P. Smith, J. Watson, 1989, International journal of cancer.

A clinical phase I toxicity study of Ro 03-8799: plasma, urine, tumour and normal brain pharmacokinetics.

N. Bleehen, P. Workman, M. Walton, 1986, The British journal of radiology.

Abnormal clinical pharmacokinetics of the developmental radiosensitizers pimonidazole (Ro 03-8799) and etanidazole (SR 2508).

N. Bleehen, P. Workman, T. Maughan, 1990, International journal of radiation oncology, biology, physics.

Effects of localised tumour hyperthermia on pimonidazole (Ro 03-8799) pharmacokinetics in mice.

N. Bleehen, P. Workman, M. Walton, 1989, British Journal of Cancer.

Interactions of hyperthermia with hypoxic cell sensitisers.

N. Bleehen, P. Workman, M. Walton, 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Pharmacology of the Hypoxic cell Radiosensitizers Ro 03-8799 and SR 2508 in Human Gliomas and Brain Tissue

N. Bleehen, P. Workman, R. Ward, 1987 .

Radiosensitivity testing of human malignant gliomas.

N. Bleehen, J. Ramsay, R. Ward, 1992, International journal of radiation oncology, biology, physics.

Tumour concentrations of flavone acetic acid (FAA) in human melanoma: comparison with mouse data.

N. Bleehen, P. Workman, T. Maughan, 1992, British Journal of Cancer.

Effect of the manipulation of oxyhemoglobin status by BW12C on tumor thermosensitivity and on blood flow in tumor and normal tissues in mice.

N. Bleehen, D. Honess, R. D. White, 1989, International journal of radiation oncology, biology, physics.

Potentiation of melphalan by systemic hyperthermia in mice: therapeutic gain for mouse lung microtumours.

N. Bleehen, D. Honess, 1985, International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group.

Thermal enhancement of drug cytotoxicity in vivo and in vitro.

N. Bleehen, D. Honess, 1988, Recent results in cancer research. Fortschritte der Krebsforschung. Progres dans les recherches sur le cancer.

Effects of elevated temperature on misonidazole O-demethylation by mouse liver microsomes: kinetic and stability studies of a model mixed-function oxidase reaction

N. Bleehen, P. Workman, M. Walton, 2004, Cancer Chemotherapy and Pharmacology.

Pentoxifylline increases RIF-1 tumour pO2 in a manner compatible with its ability to increase relative tumour perfusion.

N. Bleehen, D. Honess, R. Ward, 1995, Acta oncologica.

Japan-U.S. Joint seminar on toxicity of chlorinated biphenyls, dibenzofurans, dibenzodioxins, and related compounds. April 25-28, 1983, Fukuoka, Japan.

N. Bleehen, P. Workman, M. Walton, 1985, British journal of cancer.

Mediastinal germ cell tumour associated with malignant histiocytosis and high rubella titres

N. Bleehen, R. Buchanan, M. Ashby, 1986, Hematological oncology.

Adverse reactions and quality of life during combination chemotherapy compared with selective palliative treatment for Small-cell lung cancer

P. Fayers, D. Girling, R. Stephens, 1985 .

A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC). I: Survival and prognostic factors. Medical Research Council Lung Cancer Working Party.

R. Stephens, D. Machin, N. Bleehen, 1993, British Journal of Cancer.

Clinico-pathological features of prognostic significance in operable rectal cancer in 17 centres in the U.K. (Third report of the M.R.C. Trial, on behalf of the Working Party).

Dykes, W. H. Bond, N. Bleehen, 1984, British Journal of Cancer.

A short fractionation radiotherapy treatment for poor prognosis patients with high grade glioma.

N. Bleehen, S. Stenning, D. Boote, 1997, Clinical oncology (Royal College of Radiologists (Great Britain)).

BW12C perturbs normal and tumour tissue oxygenation and blood flow in man.

A K Dixon, N. Bleehen, A. Dixon, 1994, Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology.

In vitro and in vivo studies using BW12C: toxicity, haemoglobin modification and effects on the radiosensitivity of normal marrow and RIF-1 tumours in mice.

N. Bleehen, D. Honess, A. Nethersell, 1992, International journal of radiation biology.

Multicentre CRC phase II trial of temozolomide in recurrent or progressive high-grade glioma

N. Bleehen, M. Brada, H. Calvert, 1997, Cancer Chemotherapy and Pharmacology.

The evaluation of low dose pre‐operative X‐ray therapy in the management of operable rectal cancer; results of a randomly controlled trial

W. H. Bond, N. Bleehen, L. Fielding, 1984, The British journal of surgery.

The interaction of thermal tolerance with drug cytotoxicity in vitro.

N. Bleehen, D. Honess, J. Morgan, 1979, British Journal of Cancer.

Phase I study of etoposide with SDZ PSC 833 as a modulator of multidrug resistance in patients with cancer.

N. Bleehen, R. Osborne, J. Smyth, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Sensitivity of normal mouse marrow and RIF-1 tumour to hyperthermia combined with cyclophosphamide or BCNU: a lack of therapeutic gain.

N. Bleehen, D. Honess, 1982, British Journal of Cancer.

Pentoxifylline: its pharmacokinetics and ability to improve tumour perfusion and radiosensitivity in mice.

N. Bleehen, D. Honess, I. Dennis, 1993, Radiotherapy and Oncology.

The effect of systemic hyperthermia on melphalan pharmacokinetics in mice.

N. Bleehen, P. Workman, D. Honess, 1985, British Journal of Cancer.

Thermochemotherapy with cis-platinum, CCNU, BCNU, chlorambucil and melphalan on murine marrow and two tumours: therapeutic gain for melphalan only.

N. Bleehen, D. Honess, 1985, The British journal of radiology.

Randomized trial of palliative two-fraction versus more intensive 13-fraction radiotherapy for patients with inoperable non-small cell lung cancer and good performance status. Medical Research Council Lung Cancer Working Party.

D. Girling, R. Stephens, D. Machin, 1996, Clinical oncology (Royal College of Radiologists (Great Britain)).

Effects of local hyperthermia on the pharmacokinetics of misonidazole in the anaesthetized mouse.

N. Bleehen, P. Workman, D. Honess, 1980, British Journal of Cancer.

The hyperthermic potentiation of the cytotoxic effect of misonidazole on the EMT6 mouse tumour: relevance of in vitro measurement of in vivo effect.

N. Bleehen, D. Honess, J. Morgan, 1978, The British journal of cancer. Supplement.

A randomised trial on the efficacy of radiotherapy for cerebral low-grade glioma in the adult: EORTC study 22845 with MRC study BR04: an interim analysis

D. Áfra, O. Witte, S. Schraub, 2002 .

Randomised trial of four-drug vs less intensive two-drug chemotherapy in the palliative treatment of patients with small-cell lung cancer (SCLC) and poor prognosis. Medical Research Council Lung Cancer Working Party.

D. Machin, N. Bleehen, D. Girling, 1996, British Journal of Cancer.

A randomised trial of three or six courses of etoposide cyclophosphamide methotrexate and vincristine or six courses of etoposide and ifosfamide in small cell lung cancer (SCLC). II: Quality of life. Medical Research Council Lung Cancer Working Party.

R. Stephens, D. Machin, N. Bleehen, 1993, British Journal of Cancer.

The role of post-operative radiotherapy in non-small-cell lung cancer: a multicentre randomised trial in patients with pathologically staged T1-2, N1-2, M0 disease. Medical Research Council Lung Cancer Working Party.

R. Stephens, D. Machin, N. Bleehen, 1996, British Journal of Cancer.

Radiation myelopathy: estimates of risk in 1048 patients in three randomized trials of palliative radiotherapy for non-small cell lung cancer. The Medical Research Council Lung Cancer Working Party.

D. Girling, R. Stephens, D. Machin, 1996, Clinical oncology (Royal College of Radiologists (Great Britain)).

The reversible N-oxidation of the nitroimidazole radiosensitizer Ro 03-8799.

N. Bleehen, P. Workman, M. Walton, 1985, Biochemical pharmacology.

Pharmacokinetic evaluation of N-[2-(dimethylamino)ethyl]acridine-4-carboxamide in patients by positron emission tomography.

T Jones, S Osman, A Saleem, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Effects of two tumor blood flow modifiers, hydralazine and flavone acetic acid, on KHT tumours and normal tissues in mice.

N. Bleehen, D. Honess, 1991, International journal of radiation biology.

Non-Curative Radiotherapy for Lung Cancer

N. Bleehen, D. Boote, 1998 .

Additivity of radiosensitization by the combination of SR 2508 (etanidazole) and Ro 03-8799 (pimonidazole) in a murine tumor system.

N. Bleehen, P. Workman, T. Wasserman, 1988, International Journal of Radiation Oncology, Biology, Physics.

Estimation of plasma area under the curve for etanidazole (SR 2508) in toxicity prediction and dose adjustment.

N. Bleehen, P. Workman, T. Maughan, 1989, International journal of radiation oncology, biology, physics.

Does clinical experience with a treatment regimen affect survival of lung cancer patients? An analysis based on consecutive randomized trials of the Medical Research Council in small cell and non-small cell tumours. Medical Research Council Lung Cancer Working Party.

R. Stephens, D. Machin, N. Bleehen, 1994, Clinical oncology (Royal College of Radiologists (Great Britain)).

Carbogen breathing with nicotinamide improves the oxygen status of tumours in patients.

N. Bleehen, V. M. Laurence, R. Ward, 1995, British Journal of Cancer.

CHANGES IN CELL PROLIFERATION KINETICS OCCURRING DURING THE LIFE HISTORY OF MONOLAYER CULTURES OF A MOUSE TUMOUR CELL LINE

N. Bleehen, N. Bleehen, J. Watson, 1975, Cell and tissue kinetics.

Survival in small cell lung carcinoma after surgery

N. Bleehen, D. Girling, 1986 .

The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography.

N. Bleehen, R. Ward, S. J. Falk, 1992, British Journal of Cancer.

The influence of carbogen breathing on tumour tissue oxygenation in man evaluated by computerised p02 histography.

N. Bleehen, S. Falk, R. Ward, 1992, British Journal of Cancer.

Primary lymphoma of the central nervous system: experience at Addenbrooke's Hospital, Cambridge.

C. Freer, N. Bleehen, P. Barber, 1988, Clinical radiology.

Expression of apoptosis-regulatory genes in lung tumour cell lines: relationship to p53 expression and relevance to acquired drug resistance.

N. Bleehen, N. Bleehen, J. Xiong, 1996, British Journal of Cancer.

Paraffin wax‐embedded material as a source of DNA for the detection of somatic genetic changes

P. Ganly, P. Hasleton, N. Bleehen, 1993, The Journal of pathology.

A Medical Research Council phase II trial of alternating chemotherapy and radiotherapy in small-cell lung cancer. The Medical Research Council Lung Cancer Working Party.

R. Stephens, A. Gregor, D. Machin, 1991, British Journal of Cancer.

Cancer Research Campaign phase II trial of temozolomide in metastatic melanoma.

N. Bleehen, G. Rustin, N. Bleehen, 1995, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Production of immunoreactive insulin-like growth factor-I (IGF-I) and IGF-I binding proteins by human lung tumours.

N. Bleehen, N. Bleehen, J. A. Payne, 1990, British Journal of Cancer.

Etoposide-induced cell cycle delay and arrest-dependent modulation of DNA topoisomerase II in small-cell lung cancer cells.

N. Bleehen, N. Bleehen, T. Gottlieb, 1994, British Journal of Cancer.

European School of Oncology Advisory report to the European Commission for the "Europe Against Cancer Programme" European Code Against Cancer.

F. Alexander, P. Boyle, N. Bleehen, 1995, European journal of cancer.

Medical Research Council LungCancer Working Party* Prepared onbehalf oftheworking party andits collaborators byRJStephens', DJGirling',

N. Bleehen, K. Moghissi, H. Yosef, 1996 .