C. Chen

发表

3-Phosphoinositide-Dependent Protein Kinase-1/Akt Signaling Represents a Major Cyclooxygenase-2-Independent Target for Celecoxib in Prostate Cancer Cells

S. Kulp, Y. Yang, Chin-Chun Hung, 2004, Cancer Research.

A Novel Histone Deacetylase Inhibitor Exhibits Antitumor Activity via Apoptosis Induction, F-Actin Disruption and Gene Acetylation in Lung Cancer

Jer-Wei Chang, C. Chen, Jer-Wei Chang, 2010, PloS one.

Design and synthesis of novel anti-tuberculosis agents from the celecoxib pharmacophore.

C. Chen, A. Azad, P. Pancholi, 2015, Bioorganic & medicinal chemistry.

Therapeutic Opportunities of Targeting Histone Deacetylase Isoforms to Eradicate Cancer Stem Cells

C. Chen, P. Lin, Hao-Yu Hsieh, 2018, International journal of molecular sciences.

Phase I trial of lenalidomide and CCI-779 in patients with relapsed multiple myeloma: evidence for lenalidomide-CCI-779 interaction via P-glycoprotein.

M. Grever, J. Byrd, C. Hofmeister, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Efficacy of novel histone deacetylase inhibitor, AR42, in a mouse model of, human T-lymphotropic virus type 1 adult T cell lymphoma.

C. Chen, S. Fernandez, M. Lairmore, 2011, Leukemia research.

FTY 720 Induces Apoptosis in Hepatocellular Carcinoma Cells through Activation of Protein Kinase C D Signaling

J. Byrd, S. Kulp, C. Chen, 2008 .

FTY720 induces apoptosis in hepatocellular carcinoma cells through activation of protein kinase C delta signaling.

J. Byrd, S. Kulp, C. Chen, 2008, Cancer research.

Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer – a crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activation

C. Chen, J. Guh, Wei‐Ling Chang, 2015, Oncotarget.

Papaverine and its derivatives radiosensitize solid tumors by inhibiting mitochondrial metabolism

Albert C. Koong, Quynh-Thu Le, Martin Benej, 2018, Proceedings of the National Academy of Sciences.

Higher doses of lenalidomide are associated with unacceptable toxicity including life-threatening tumor flare in patients with chronic lymphocytic leukemia.

Lisa L. Smith, J. Byrd, F. Awan, 2008, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

A Novel Mechanism by Which Thiazolidinediones Facilitate the Proteasomal Degradation of Cyclin D1 in Cancer Cells*

Pei-Jung Lu, S. Kulp, C. Chen, 2008, Journal of Biological Chemistry.

The mRNA-stabilizing Factor HuR Protein Is Targeted by β-TrCP Protein for Degradation in Response to Glycolysis Inhibition*

S. Kulp, C. Chen, Po-Chen Chu, 2012, The Journal of Biological Chemistry.

Peroxisome Proliferator-Activated Receptor γ-Independent Ablation of Cyclin D1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells

C. Shapiro, S. Kulp, Y. Yang, 2005, Molecular Pharmacology.

Peroxisome proliferator-activated receptor gamma-independent suppression of androgen receptor expression by troglitazone mechanism and pharmacologic exploitation.

C. Chen, Yu-Chieh Wang, Chih-Cheng Yang, 2007, Cancer research.

OSU‐DY7, a novel D‐tyrosinol derivative, mediates cytotoxicity in chronic lymphocytic leukaemia and Burkitt lymphoma through p38 mitogen‐activated protein kinase pathway

J. Byrd, S. Kulp, C. Chen, 2011, British journal of haematology.

Increased PTEN expression due to transcriptional activation of PPARγ by Lovastatin and Rosiglitazone

C. Chen, C. Eng, K. Waite, 2006, International journal of cancer.

Targeting integrin-linked kinase to suppress oncogenic KRAS signaling in pancreatic cancer

S. Kulp, C. Chen, T. Bekaii-Saab, 2018, Small GTPases.

Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repair.

C. Chen, J. Guh, Y. Ho, 2012, Cancer letters.

Mitochondrial Apoptosis and FAK Signaling Disruption by a Novel Histone Deacetylase Inhibitor, HTPB, in Antitumor and Antimetastatic Mouse Models

C. Chen, P. Lin, J. Shieh, 2012, PloS one.

A novel HIF-1α-integrin-linked kinase regulatory loop that facilitates hypoxia-induced HIF-1α expression and epithelial-mesenchymal transition in cancer cells

S. Kulp, C. Chen, S. Salunke, 2015, Oncotarget.

Antitumor effects of OSU‐2S, a nonimmunosuppressive analogue of FTY720, in hepatocellular carcinoma

J. Byrd, S. Kulp, C. Chen, 2011, Hepatology.

AR-42, a novel HDAC inhibitor, exhibits biologic activity against malignant mast cell lines via down-regulation of constitutively activated Kit.

S. Kulp, C. Chen, Dasheng Wang, 2010, Blood.

Minocycline, a putative neuroprotectant, co-administered with doxorubicin-cyclophosphamide chemotherapy in a xenograft model of triple-negative breast cancer.

S. Kulp, C. Chen, M. Poi, 2016, Experimental and toxicologic pathology : official journal of the Gesellschaft fur Toxikologische Pathologie.

FTY720 increases CD74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death.

J. Byrd, C. Chen, R. Baiocchi, 2011, Blood.

FTY 720 increases CD 74 expression and sensitizes mantle cell lymphoma cells to milatuzumab-mediated cell death

J. Byrd, C. Chen, M. Prætorius-Ibba, 2011 .

PERK-dependent regulation of HSP70 expression and the regulation of autophagy

P. Fisher, C. Chen, P. Dent, 2008, Autophagy.

OSU-03012 stimulates PERK-dependent increases in HSP 70 expression , attenuating its lethal actions in transformed cells

P. Fisher, S. Spiegel, C. Chen, 2007 .

AMPK as a potential anticancer target - friend or foe?

S. Kulp, C. Chen, H. Chuang, 2014, Current pharmaceutical design.

Cancer Therapy : Preclinical Synergistic Interaction between the HDAC Inhibitor , MPT 0 E 028 , and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

C. Chen, C. Teng, S. Pan, 2014 .

Cellular prostatic acid phosphatase (cPAcP) serves as a useful biomarker of histone deacetylase (HDAC) inhibitors in prostate cancer cell growth suppression

C. Chen, Y. Chou, Sakthivel Muniyan, 2015, Cell & Bioscience.

Synergistic Interaction between the HDAC Inhibitor, MPT0E028, and Sorafenib in Liver Cancer Cells In Vitro and In Vivo

C. Chen, C. Teng, S. Pan, 2014, Clinical Cancer Research.

Synergistic Interactions between Imatinib and the Novel Phosphoinositide-Dependent Kinase-1 Inhibitor OSU-03012 in Overcoming Imatinib Resistance Running title : Overcome imatinib resistance by a PDK-1 inhibitor

M. Grever, J. Byrd, E. Hade, 2005 .

Evaluation of the effects of histone deacetylase inhibitors on cells from canine cancer cell lines.

S. Kulp, C. Chen, W. Kisseberth, 2008, American journal of veterinary research.

Functional Role of mTORC2 versus Integrin-Linked Kinase in Mediating Ser473-Akt Phosphorylation in PTEN-Negative Prostate and Breast Cancer Cell Lines

J. Byrd, Su-Lin Lee, S. Kulp, 2013, PloS one.

A Review of the Existing Grading Schemes and a Proposal for a Modified Grading Scheme for Prostatic Lesions in TRAMP Mice

S. Kulp, C. Chen, T. Rosol, 2012, Toxicologic pathology.

Growth inhibitory and anti-tumour activities of OSU-03012, a novel PDK-1 inhibitor, on vestibular schwannoma and malignant schwannoma cells.

D. Welling, S. Kulp, C. Chen, 2009, European journal of cancer.

Histone deacetylase inhibitor AR-42 differentially affects cell-cycle transit in meningeal and meningioma cells, potently inhibiting NF2-deficient meningioma growth.

D. Welling, C. Chen, Sarah S. Burns, 2013, Cancer research.

Troglitazone and Δ2Troglitazone Enhance Adiponectin Expression in Monocytes/Macrophages through the AMP-Activated Protein Kinase Pathway

C. Chen, L. Chuang, Yuh-Lien Chen, 2014, Mediators of inflammation.

Multi-kinase inhibitors can associate with heat shock proteins through their NH2-termini by which they suppress chaperone function

B. Shuch, C. Chen, Dasheng Wang, 2016, Oncotarget.

2-Amino-N-{4-[5-(2-phenanthrenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]-phenyl} Acetamide (OSU-03012), a Celecoxib Derivative, Directly Targets p21-Activated Kinase

S. Kulp, C. Chen, M. Saji, 2007, Molecular Pharmacology.

Sensitive liquid chromatography/mass spectrometry methods for quantification of pomalidomide in mouse plasma and brain tissue.

J. Byrd, C. Hofmeister, C. Chen, 2014, Journal of pharmaceutical and biomedical analysis.

Development of novel adenosine monophosphate-activated protein kinase activators.

Su-Lin Lee, S. Kulp, C. Chen, 2010, Journal of medicinal chemistry.

Tetraspanin CD37 directly mediates transduction of survival and apoptotic signals.

Michael A. Freitas, Jeffrey A Jones, J. Byrd, 2012, Cancer cell.

Structure-based optimization of phenylbutyrate-derived histone deacetylase inhibitors.

C. Chen, Dasheng Wang, Ching-shih Chen, 2005, Journal of medicinal chemistry.

Clinical Implications of Using Racemic Drugs

C. Chen, W. Shieh, Ching-Yu Chen, 1992 .

FTY720 demonstrates promising preclinical activity for chronic lymphocytic leukemia and lymphoblastic leukemia/lymphoma.

J. Byrd, C. Chen, D. Jarjoura, 2008, Blood.

OSU03012, a novel PDK1 inhibitor, decreases thyroid cancer proliferation and migration via multiple downstream pathways.

S. Kulp, C. Chen, M. Saji, 2006 .

FTY720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D1 and Phospho-Akt in Mantle Cell Lymphoma

J. Byrd, C. Chen, R. Baiocchi, 2010, Clinical Cancer Research.

A 5′ AMP‐Activated Protein Kinase Enzyme Activator, Compound 59, Induces Autophagy and Apoptosis in Human Oral Squamous Cell Carcinoma

Tzong-Ming Shieh, C. Chen, L. Bai, 2018, Basic & clinical pharmacology & toxicology.

FTY 720 Shows Promising In vitro and In vivo Preclinical Activity by Downmodulating Cyclin D 1 and Phospho-Akt in Mantle Cell Lymphoma

J. Byrd, C. Chen, R. Baiocchi, 2010 .

Peroxisome Proliferator-Activated Receptor-Independent Ablation of Cyclin D 1 by Thiazolidinediones and Their Derivatives in Breast Cancer Cells

C. Shapiro, S. Kulp, Kuen-Feng Chen, 2005 .

Identification and Characterization of a Novel Integrin-Linked

Su-Lin Lee, C. Chen, L. Bai, 2012 .

Identification and characterization of a novel integrin-linked kinase inhibitor.

Su-Lin Lee, S. Kulp, C. Chen, 2011, Journal of medicinal chemistry.

Therapeutics targeting CD90-integrin-AMPK-CD133 signal axis in liver cancer

C. Chen, M. Lai, Chih-Yang Wang, 2015, Oncotarget.

The humanized CD40 antibody SGN‐40 demonstrates pre‐clinical activity that is enhanced by lenalidomide in chronic lymphocytic leukaemia

M. Caligiuri, J. Byrd, C. Chen, 2009, British journal of haematology.

Overcoming Resistance to Anabolic Selective Androgen Receptor Modulator (SARM) Therapy in Experimental Cancer Cachexia with Histone Deacetylase Inhibitor AR-42

Michael G. Sovic, S. Kulp, C. Chen, 2018, bioRxiv.

Eradication of Intracellular Salmonellaenterica Serovar Typhimurium with a Small-Molecule, Host Cell-Directed Agent

S. Kulp, C. Chen, Dasheng Wang, 2009, Antimicrobial Agents and Chemotherapy.

Lenalidomide down-regulates the CD20 antigen and antagonizes direct and antibody-dependent cellular cytotoxicity of rituximab on primary chronic lymphocytic leukemia cells.

Lisa L. Smith, J. Byrd, L. J. Lee, 2008, Blood.

Extra-prostatic Transgene-associated Neoplastic Lesions in Transgenic Adenocarcinoma of the Mouse Prostate (TRAMP) Mice

S. Kulp, C. Chen, K. L. La Perle, 2015, Toxicologic pathology.

Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na⁺/K⁺-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades.

C. Chen, J. Guh, T. Hwang, 2013, Biochemical pharmacology.

Retraction: Sensitizing Estrogen Receptor–negative Breast Cancer Cells to Tamoxifen with OSU-03012, a Novel Celecoxib-derived Phosphoinositide-dependent Protein Kinase-1/Akt Signaling Inhibitor

C. Shapiro, S. Kulp, C. Chen, 2008, Molecular Cancer Therapeutics.

Sensitizing estrogen receptor–negative breast cancer cells to tamoxifen with OSU-03012, a novel celecoxib-derived phosphoinositide-dependent protein kinase-1/Akt signaling inhibitor

C. Shapiro, S. Kulp, C. Chen, 2008, Molecular Cancer Therapeutics.

A novel liposomal formulation of FTY720 (fingolimod) for promising enhanced targeted delivery.

J. Byrd, L. J. Lee, C. Chen, 2014, Nanomedicine : nanotechnology, biology, and medicine.

Quantification of OSU-2S, a novel derivative of FTY720, in mouse plasma by liquid chromatography-tandem mass spectrometry.

J. Byrd, L. J. Lee, C. Chen, 2014, Journal of pharmaceutical and biomedical analysis.

Non-epigenetic function of HDAC8 in regulating breast cancer stem cells by maintaining Notch1 protein stability

S. Kulp, C. Chen, C. Teng, 2015, Oncotarget.

Therapeutics , Targets , and Chemical Biology Histone Deacetylase Inhibitor AR-42 Differentially Affects Cell-cycle Transit in Meningeal and Meningioma Cells , Potently Inhibiting NF 2-De fi cient Meningioma Growth

D. Welling, C. Chen, Sarah S. Burns, 2013 .

Synthesis and biological evaluation of 1-arylsulfonyl-5-(N-hydroxyacrylamide)indoles as potent histone deacetylase inhibitors with antitumor activity in vivo.

C. Chen, C. Teng, S. Pan, 2012, Journal of medicinal chemistry.

ROR1-targeted delivery of OSU-2S, a nonimmunosuppressive FTY720 derivative, exerts potent cytotoxicity in mantle-cell lymphoma in vitro and in vivo.

J. Byrd, L. J. Lee, C. Chen, 2015, Experimental Hematology.