J. Katzenellenbogen

发表

Resveratrol modulates the inflammatory response via an estrogen receptor-signal integration network

J. Nwachukwu, S. Srinivasan, N. Bruno, 2014, eLife.

Steroidal bivalent ligands for the estrogen receptor: design, synthesis, characterization and binding affinities.

J. Katzenellenbogen, Andrew L. LaFrate, K. Carlson, 2009, Bioorganic & medicinal chemistry.

Bivalent ligands as probes of estrogen receptor action

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1994, The Journal of Steroid Biochemistry and Molecular Biology.

Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications.

Daniel Henrion, Pierre Chambon, Gilles Flouriot, 2017, Physiological reviews.

Metabolic flare: indicator of hormone responsiveness in advanced breast cancer.

M. Welch, K. Trinkaus, J. Katzenellenbogen, 2001, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Preparation of four fluorine- 18-labeled estrogens and their selective uptakes in target tissues of immature rats.

M. Welch, J. Katzenellenbogen, D. Kiesewetter, 1984, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

PI3K inhibition results in enhanced estrogen receptor function and dependence in hormone receptor–positive breast cancer

Michael G. Kharas, A. Bergamaschi, S. Chandarlapaty, 2015, Science Translational Medicine.

Diffusion tensor imaging identifies aspects of therapeutic estrogen receptor β ligand-induced remyelination in a mouse model of multiple sclerosis

A. Obenaus, J. Katzenellenbogen, S. Tiwari-Woodruff, 2019, Neurobiology of Disease.

VAV3 mediates resistance to breast cancer endocrine therapy

F. Climent, Yusuke Nakamura, M. Esteller, 2014, Breast Cancer Research.

The estradiol pharmacophore: Ligand structure-estrogen receptor binding affinity relationships and a model for the receptor binding site

John A. Katzenellenbogen, Kathryn E. Carlson, J. Katzenellenbogen, 1997, Steroids.

Radiochemical synthesis and tissue distribution of Tc-99m-labeled 7alpha-substituted estradiol complexes.

M. Welch, J. Katzenellenbogen, H. Spies, 2000, Nuclear medicine and biology.

Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor α coactivator binding

J. Katzenellenbogen, Alice L. Rodriguez, A. Tamrazi, 2004 .

Retardation of 17-oxidation of 16α-[18F]fluoroestradiol-17β by substitution of deuterium for hydrogen in the 17α position(6)

M. Welch, J. Katzenellenbogen, T. Bonasera, 1997 .

Nitrosourea and nitrosocarbamate derivatives of the antiestrogen tamoxifen as potential estrogen receptor-mediated cytotoxic agents in human breast cancer cells

B. Katzenellenbogen, J. Katzenellenbogen, D. Simpson, 2005, Breast Cancer Research and Treatment.

The SERM/SERD Bazedoxifene Disrupts ESR1 Helix 12 to Overcome Acquired Hormone Resistance in Breast Cancer Cells

Myles A Brown, S. Chandarlapaty, E. Tajkhorshid, 2018, bioRxiv.

Alternative inhibition of androgen receptor signaling: peptidomimetic pyrimidines as direct androgen receptor/coactivator disruptors.

A. Parent, J. Katzenellenbogen, J. R. Gunther, 2009, ACS chemical biology.

Suppression of Tumor Growth, Metastasis, and Signaling Pathways by Reducing FOXM1 Activity in Triple Negative Breast Cancer

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2020, Cancers.

Selenophenes: Introducing a New Element into the Core of Non‐Steroidal Estrogen Receptor Ligands

J. Katzenellenbogen, K. Carlson, Junjie Luo, 2017, ChemMedChem.

Triaryl-Substituted Schiff Bases Are High-Affinity Subtype-Selective Ligands for the Estrogen Receptor

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2014, Journal of medicinal chemistry.

Synthesis of a tetrafluoro-substituted aryl azide and its protio analog as photoaffinity labeling reagents for the estrogen receptor

J. Katzenellenbogen, K. Pinney, 1991 .

Efficient and selective photoaffinity labeling of the estrogen receptor using two nonsteroidal ligands that embody aryl azide or tetrafluoroaryl azide photoreactive functions.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1991, Biochemistry.

Exploration of Dimensions of Estrogen Potency

J. Katzenellenbogen, K. Carlson, J. R. Gunther, 2011, The Journal of Biological Chemistry.

Coactivator proteins as determinants of estrogen receptor structure and function: spectroscopic evidence for a novel coactivator-stabilized receptor conformation.

J. Katzenellenbogen, K. Carlson, Alice L. Rodriguez, 2005, Molecular endocrinology.

A Proteomic Microarray Approach for Exploring Ligand-initiated Nuclear Hormone Receptor Pharmacology, Receptor Selectivity, and Heterodimer Functionality*

J. Katzenellenbogen, K. Carlson, Sung Hoon Kim, 2005, Molecular & Cellular Proteomics.

Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta.

B. Katzenellenbogen, J. Katzenellenbogen, B. Fink, 1999, Endocrinology.

A novel connector linkage applicable in prodrug design.

J. Katzenellenbogen, P. Chakravarty, J A Katzenellenbogen, 1981, Journal of medicinal chemistry.

Activating ESR1 Mutations Differentially Affect the Efficacy of ER Antagonists.

S. Chandarlapaty, J. Baselga, J. Katzenellenbogen, 2017, Cancer discovery.

Allosteric control of ligand selectivity between estrogen receptors alpha and beta: implications for other nuclear receptors.

B. Katzenellenbogen, J. Katzenellenbogen, K. Nettles, 2004, Molecular cell.

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2016, Steroids.

Designer antiandrogens join the race against drug resistance

J. Katzenellenbogen, J. Josan, 2013, eLife.

a cancer drug and its receptor, it may be possible to strategically redesign existing drugs and win the race against mutations that lead to drug resistance in prostate cancer.

J. Katzenellenbogen, J. Josan, 2013 .

Comparative breast tumor imaging and comparative in vitro metabolism of 16α-[18F]Fluoroestradiol-17β and 16β-[18f]fluoromoxestrol in isolated hepatocytes

M. Welch, J. Katzenellenbogen, F. Dehdashti, 1999 .

Non-Genomic Estrogen Regulation of Ion Transport and Airway Surface Liquid Dynamics in Cystic Fibrosis Bronchial Epithelium

J. Katzenellenbogen, B. Harvey, Sung Hoon Kim, 2013, PloS one.

Synthesis and evaluation of aryl-substituted diarylpropionitriles, selective ligands for estrogen receptor beta, as positron-emission tomographic imaging agents.

G. Cheon, J. Katzenellenbogen, H. Koh, 2009, Bioorganic & medicinal chemistry.

Ring nitrogen-substituted non-steroidal estrogens: pyridine and pyrimidine analogs of the phenol in deoxyhexestrol experience resonance constraints on preferred ligand conformation.

J. Katzenellenbogen, M. De Angelis, 2004, Bioorganic & medicinal chemistry letters.

Estrogen receptor-beta potency-selective ligands: structure-activity relationship studies of diarylpropionitriles and their acetylene and polar analogues.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2001, Journal of medicinal chemistry.

Mechanisms enforcing the estrogen receptor β selectivity of botanical estrogens

B. Katzenellenbogen, J. Katzenellenbogen, I. Khan, 2013, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Estrogen Receptor-α Agonists Promote Angiogenesis in Human Myometrial Microvascular Endothelial Cells

J. Katzenellenbogen, M. Zaitseva, P. Rogers, 2004, The Journal of the Society for Gynecologic Investigation: JSGI.

A rapid and efficient method for the fluoroalkylation of amines and amides. Development of a method suitable for incorporation of the short-lived positron emitting radionuclide fluorine-18

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1987 .

Discovering Small‐Molecule Estrogen Receptor α/Coactivator Binding Inhibitors: High‐Throughput Screening, Ligand Development, and Models for Enhanced Potency

J. Snyder, J. Katzenellenbogen, H. Fu, 2011, ChemMedChem.

Amphipathic benzenes are designed inhibitors of the estrogen receptor alpha/steroid receptor coactivator interaction.

J. Katzenellenbogen, M. Collins, J. R. Gunther, 2008, ACS chemical biology.

Synthesis and biological evaluation of [18F]bicalutamide, 4-[76Br]bromobicalutamide, and 4-[76Br]bromo-thiobicalutamide as non-steroidal androgens for prostate cancer imaging.

Ephraim E. Parent, C. Dence, T. Sharp, 2007, Journal of medicinal chemistry.

Endogenous estrogen receptor β is transcriptionally active in primary ovarian cells from estrogen receptor knockout mice

J. Katzenellenbogen, S. O. Mueller, K. Korach, 2004, Steroids.

Activities of estrogen receptor alpha- and beta-selective ligands at diverse estrogen responsive gene sites mediating transactivation or transrepression

B. Katzenellenbogen, J. Katzenellenbogen, L. N. Petz, 2003, Molecular and Cellular Endocrinology.

Equol, a natural estrogenic metabolite from soy isoflavones: convenient preparation and resolution of R- and S-equols and their differing binding and biological activity through estrogen receptors alpha and beta.

B. Katzenellenbogen, J. Katzenellenbogen, Y. Ju, 2004, Bioorganic & medicinal chemistry.

7α-18F-Fluoromethyl-Dihydrotestosterone and 7α-18F-Fluoromethyl-Nortestosterone: Ligands to Determine the Role of Sex Hormone–Binding Globulin for Steroidal Radiopharmaceuticals

Ephraim E. Parent, C. Dence, T. Sharp, 2008, Journal of Nuclear Medicine.

Chiral dimethylamine flutamide derivatives--modeling, synthesis, androgen receptor affinities and carbon-11 labeling.

J. Katzenellenbogen, K. Carlson, R. Chisin, 2006, Nuclear medicine and biology.

Synthesis and biological evaluation of a fluorine-18-labeled nonsteroidal androgen receptor antagonist, N-(3-[18F]fluoro-4-nitronaphthyl)-cis-5-norbornene-endo-2,3-dicarboxylic imide.

Ephraim E. Parent, C. Dence, T. Sharp, 2006, Nuclear medicine and biology.

Synthesis and biological evaluation of a nonsteroidal bromine-76-labeled androgen receptor ligand 3-[76Br]bromo-hydroxyflutamide.

Ephraim E. Parent, T. Sharp, M. Welch, 2006, Nuclear medicine and biology.

Predominant Role of Nuclear Versus Membrane Estrogen Receptor α in Arterial Protection: Implications for Estrogen Receptor α Modulation in Cardiovascular Prevention/Safety

B. Katzenellenbogen, J. Foidart, J. Katzenellenbogen, 2018, Journal of the American Heart Association.

Estrogen receptors alpha (ERα) and beta (ERβ): Subtype-selective ligands and clinical potential

J. Katzenellenbogen, F. Minutolo, C. Granchi, 2014, Steroids.

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2004, Farmaco.

Estrogen and antiestrogen action in reproductive tissues and tumors.

B. Katzenellenbogen, J. Katzenellenbogen, N. Lan, 1979, Recent progress in hormone research.

NCA 16α-[18F]fluoroestradiol-17β: The effect of reaction vessel on fluorine-18 resolubilization, product yield, and effective specific activity

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1986 .

Synthesis and tissue distribution of fluorine-18 labeled trifluorohexadecanoic acids. Considerations in the development of metabolically blocked myocardial imaging agents.

S. Pochapsky, M. Welch, J. Katzenellenbogen, 1990, Bioconjugate chemistry.

Synthesis of high affinity fluorine-substituted ligands for the androgen receptor. Potential agents for imaging prostatic cancer by positron emission tomography.

J. Katzenellenbogen, K. Carlson, A. Liu, 1992, Journal of medicinal chemistry.

Synthesis of 11 beta-[18F]fluoro-5 alpha-dihydrotestosterone and 11 beta-[18F]fluoro-19-nor-5 alpha-dihydrotestosterone: preparation via halofluorination-reduction, receptor binding, and tissue distribution.

M. Welch, J. Katzenellenbogen, Y. Choe, 1995, Journal of medicinal chemistry.

Characterization of the uptake of 16α-([18F]fluoro)-17β-estradiol in DMBA-induced mammary tumors

M. Welch, J. Katzenellenbogen, K. Carlson, 1987 .

Determination of the absolute configuration of the nonsteroidal contraceptive agent centchroman by X-ray crystallography on its N-methyl iodide salt

Scott R. Wilson, J. Katzenellenbogen, I. Dwivedy, 1996 .

Estrogen receptors: selective ligands, partners, and distinctive pharmacology.

B. Katzenellenbogen, J. Katzenellenbogen, M. Montano, 2000, Recent progress in hormone research.

FOXM1 regulates glycolysis and energy production in multiple myeloma

B. Katzenellenbogen, F. Zhan, P. Hari, 2022, Oncogene.

Free Fatty Acids Rewire Cancer Metabolism in Obesity-Associated Breast Cancer via Estrogen Receptor and mTOR Signaling.

J. Katzenellenbogen, J. Flaws, Sung Hoon Kim, 2019, Cancer research.

William C. Eckelman: An anchor of stability with a quiet voice that nurtured a new field.

J. Katzenellenbogen, H. Coenen, M. Kilbourn, 2021, Nuclear medicine and biology.

The development of estrogen and progestin radiopharmaceuticals for imaging breast cancer.

M. Welch, J. Katzenellenbogen, F. Dehdashti, 1997, Anticancer research.

Synthesis and biological evaluation of two agents for imaging estrogen receptor β by positron emission tomography: challenges in PET imaging of a low abundance target.

C. Dence, T. Sharp, M. Welch, 2012, Nuclear medicine and biology.

Estrogenicity of the Isoflavone Metabolite Equol on Reproductive and Non-Reproductive Organs in Mice1

J. Katzenellenbogen, P. Cooke, Y. Ju, 2004, Biology of reproduction.

Estrogens and selective estrogen receptor modulators differentially antagonize Runx2 in ST2 mesenchymal progenitor cells

Dustin E. Schones, B. Frenkel, J. Katzenellenbogen, 2018, The Journal of Steroid Biochemistry and Molecular Biology.

Evaluation of a bromine-76-labeled progestin 16alpha,17alpha-dioxolane for breast tumor imaging and radiotherapy: in vivo biodistribution and metabolic stability studies.

T. Sharp, Jason S. Lewis, M. Welch, 2008, Nuclear medicine and biology.

Synthesis and binding affinities of fluoroalkylated raloxifenes.

J. Katzenellenbogen, Kyo-Chul Lee, D. Chi, 2003, Bioorganic & medicinal chemistry.

Application of robotics to radiopharmaceutical preparation: controlled synthesis of fluorine-18 16 alpha-fluoroestradiol-17 beta.

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1986, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Dual-mode fluorophore-doped nickel nitrilotriacetic acid-modified silica nanoparticles combine histidine-tagged protein purification with site-specific fluorophore labeling.

J. Katzenellenbogen, Sung Hoon Kim, M. Jeyakumar, 2007, Journal of the American Chemical Society.

16β-((18F)Fluoro)estrogens: Systematic Investigation of a New Series of Fluorine-18-Labeled Estrogens as Potential Imaging Agents for Estrogen-Receptor-Positive Breast Tumors.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993 .

Russ B. Altman, Tianyun Liu, John A. Katzenellenbogen, 2019, Nature Communications.

Structurally Novel Antiestrogens Elicit Differential Responses from Constitutively Active Mutant Estrogen Receptors in Breast Cancer Cells and Tumors.

B. Katzenellenbogen, J. Katzenellenbogen, K. Nettles, 2017, Cancer research.

Fluorine-18-labeled androgens: radiochemical synthesis and tissue distribution studies on six fluorine-substituted androgens, potential imaging agents for prostatic cancer.

C. Dence, M. Welch, J. Katzenellenbogen, 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

c-Src modulates estrogen-induced stress and apoptosis in estrogen-deprived breast cancer cells.

O. Griffith, J. Gray, J. Katzenellenbogen, 2013, Cancer research.

Nonnuclear Estrogen Receptor Activation Improves Hepatic Steatosis in Female Mice.

B. Katzenellenbogen, J. Katzenellenbogen, C. Mineo, 2016, Endocrinology.

Zearalenones: characterization of the estrogenic potencies and receptor interactions of a series of fungal beta-resorcylic acid lactones.

B. Katzenellenbogen, J. Katzenellenbogen, D. Mordecai, 1979, Endocrinology.

11β-Chloromethyl-[3H] estradiol-17β: a very high affinity, reversible ligand for the estrogen receptor

J. Katzenellenbogen, K. Carlson, G. Reiner, 1987 .

Estrogen pyrazoles: defining the pyrazole core structure and the orientation of substituents in the ligand binding pocket of the estrogen receptor.

J. Katzenellenbogen, S. Stauffer, Y. Huang, 2001, Bioorganic & medicinal chemistry.

Aromatic Fluorination by Decomposition of Triazenes in Ionic Liquids

Dong Wook Kim, J. Katzenellenbogen, Changhu Chu, 2005 .

Bibenzyl- and stilbene-core compounds with non-polar linker atom substituents as selective ligands for estrogen receptor beta.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2009, European journal of medicinal chemistry.

Characterization of the estrogen receptor and its dynamics in MCF-7 human breast cancer cells using a covalently attaching antiestrogen.

B. Katzenellenbogen, F. Monsma, J. Katzenellenbogen, 1984, Endocrinology.

CHAPTER 1 – Affinity Labeling as a Technique in Determining Hormone Mechanisms

J. Katzenellenbogen, 1977 .

Estrogen photoaffinity labels. 2. Reversible binding and covalent attachment of photosensitive hexestrol derivatives to the uterine estrogen receptor.

J. Katzenellenbogen, K. Carlson, H. J. Johnson, 1977, Biochemistry.

Ultraviolet photosensitivity of the estrogen binding protein from rat uterus. Wavelength and ligand dependence. Photocovalent attachment of estrogens to proteins.

J. Katzenellenbogen, K. Carlson, J. Gorski, 1975, Biochemistry.

Iodohexestrols. II. Characterization of the binding and estrogenic activity of iodinated hexestrol derivatives, in vitro and in vivo.

B. Katzenellenbogen, W. McGuire, J. Katzenellenbogen, 1975, Biochemistry.

Fluorine-18 labeling and biodistribution studies on peroxisome proliferator-activated receptor-gamma ligands: potential positron emission tomography imaging agents.

Ephraim E. Parent, C. Dence, M. Welch, 2009, Nuclear medicine and biology.

Fluorine-substituted ligands for the peroxisome proliferator-activated receptor gamma (PPARgamma): potential imaging agents for metastatic tumors.

M. Welch, J. Katzenellenbogen, S. Jonson, 2001, Bioconjugate chemistry.

Transcriptomic analysis identifies gene networks regulated by estrogen receptor α (ERα) and ERβ that control distinct effects of different botanical estrogens

B. Katzenellenbogen, Jianlin Cheng, J. Katzenellenbogen, 2014, Nuclear receptor signaling.

Antagonists Selective for Estrogen Receptor α.

B. Katzenellenbogen, J. Katzenellenbogen, Shubin Sheng, 2002, Endocrinology.

Estrogen Receptor Isoform‐Specific Induction of Progesterone Receptors in Human Osteoblasts

B. Katzenellenbogen, B. L. Riggs, J. Katzenellenbogen, 2002, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Estrone interaction with the rat uterus: in vitro response and nuclear uptake.

B. Katzenellenbogen, J. Katzenellenbogen, J. Gorski, 1973, Endocrinology.

Fluorine-substituted corticosteroids: synthesis and evaluation as potential receptor-based imaging agents for positron emission tomography of the brain.

M. Welch, M. Pomper, J. Katzenellenbogen, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Radiosynthesis and Evaluation of Talazoparib and Its Derivatives as PARP-1-Targeting Agents

J. Katzenellenbogen, S. Afrin, J. Garbow, 2021, Biomedicines.

Evaluation of a highly efficient aryl azide photoaffinity labeling reagent for the progesterone receptor.

J. Katzenellenbogen, K. Carlson, P. Kym, 1995, Bioconjugate chemistry.

Hexestrol diazirine photoaffinity labeling reagent for the estrogen receptor.

J. Katzenellenbogen, K. Carlson, K. Bergmann, 1994, Bioconjugate chemistry.

[3H]DU41165: a high affinity ligand and novel photoaffinity labeling reagent for the progesterone receptor.

J. Katzenellenbogen, K. Carlson, K. Pinney, 1990, Journal of steroid biochemistry.

Receptor binding of NBD-labeled fluorescent estrogens and progestins in whole cells and cell-free preparations.

J. Katzenellenbogen, K. Carlson, H. Magdelenat, 1989, Journal of steroid biochemistry.

Optimization of the preparation of fluorine-18-labeled steroid receptor ligands 16alpha-[18F]fluoroestradiol (FES), [18F]fluoro furanyl norprogesterone (FFNP), and 16beta-[18F]fluoro-5alpha-dihydrotestosterone (FDHT) as radiopharmaceuticals.

C. Dence, J. Katzenellenbogen, M. Al-Qahtani, 2014, Journal of labelled compounds & radiopharmaceuticals.

Estrogen and Progestin Radiopharmaceuticals for Imaging Breast Cancer

J. Katzenellenbogen, 1997 .

Coactivator peptides have a differential stabilizing effect on the binding of estrogens and antiestrogens with the estrogen receptor.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1999, Molecular endocrinology.

A chiral pool approach for asymmetric syntheses of both antipodes of equol and sativan

J. Katzenellenbogen, I. Khan, W. Helferich, 2018 .

Estrogen inhibition of cystic fibrosis transmembrane conductance regulator-mediated chloride secretion.

J. Katzenellenbogen, A. K. Singh, R. Bridges, 2000, The Journal of pharmacology and experimental therapeutics.

Efficient synthesis of (2R,3S)-2-amino-3-(benzyloxy)-4,4,4-trifluorobutanoic acid (4,4,4-trifluoro-OBn-d-allothreonine)

Chris P. Miller, J. Katzenellenbogen, G. Hattersley, 2010 .

Analysis of the structural core of the human estrogen receptor ligand binding domain by selective proteolysis/mass spectrometric analysis.

J. Katzenellenbogen, K. Carlson, G. Greene, 1995, Biochemistry.

Synthesis and biodistribution of fluorine-18-labeled fluorocyclofenils for imaging the estrogen receptor.

Michael J Welch, C. Dence, M. Welch, 2007, Nuclear medicine and biology.

Methodology for the synthesis and specific activity determination of 16 alpha-[77Br]-bromoestradiol-17 beta and 16 alpha-[77Br]-11 beta-methoxyestradiol-17 beta, two estrogen receptor-binding radiopharmaceuticals.

M. Welch, J. Katzenellenbogen, K. Carlson, 1982, The International journal of applied radiation and isotopes.

Bridged bicyclic cores containing a 1,1-diarylethylene motif are high-affinity subtype-selective ligands for the estrogen receptor.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2003, Journal of medicinal chemistry.

The pharmacology of steroid radiopharmaceuticals: specific and non-specific binding and uptake selectivity

J. Katzenellenbogen, 1992 .

Synthesis of an estrogen receptor beta-selective radioligand: 5-[18F]fluoro-(2R,3S)-2,3-bis(4-hydroxyphenyl)pentanenitrile and comparison of in vivo distribution with 16alpha-[18F]fluoro-17beta-estradiol.

C. Dence, T. Sharp, M. Welch, 2005, Journal of medicinal chemistry.

16α-[77Br]Bromoestradiol-17β: A High Specific-Activity, Gamma-Emitting Tracer with Uptake in Rat Uterus and Induced Mammary Tumors

M. Welch, J. Katzenellenbogen, S. G. Senderoff, 1981 .

Synthesis and biological evaluation of a novel series of furans: Ligands selective for estrogen receptor α

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2001 .

Titration of the in vivo uptake of 16 alpha-[18F]fluoroestradiol by target tissues in the rat: competition by tamoxifen, and implications for quantitating estrogen receptors in vivo and the use of animal models in receptor-binding radiopharmaceutical development.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993, Nuclear medicine and biology.

Synthesis and biological evaluation of a novel series of furans: ligands selective for estrogen receptor alpha.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2001, Journal of medicinal chemistry.

Methodology for the synthesis and specific activity determination of 16α-[77Br]-Bromoestradiol-17 β and 16α-[77Br]-11 β-methoxyestradiol-17 β, Two estrogen receptor-binding radiopharmaceuticals

M. Welch, J. Katzenellenbogen, D. Heiman, 1982 .

16 beta-([18F]fluoro)estrogens: systematic investigation of a new series of fluorine-18-labeled estrogens as potential imaging agents for estrogen-receptor-positive breast tumors.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993, Journal of medicinal chemistry.

16 alpha-[77Br]bromoestradiol: dosimetry and preliminary clinical studies.

M. Welch, J. Katzenellenbogen, B. Siegel, 1982, Journal of Nuclear Medicine.

(2R*,3S*)-1-[125I]Iodo-2,3-bis(4-hydroxyphenyl)pentane ([125I]iodonorhexestrol) and (2R*,3S*)-1-[77Br]Bromo-2,3-bis(4-hydroxyphenyl)pentane ([77Br]bromonorhexestrol), two gamma-emitting estrogens that show receptor-mediated uptake by target tissues in vivo.

M. Welch, J. Katzenellenbogen, S. Landvatter, 1982, Journal of Medicinal Chemistry.

Oxohexestrol derivatives labeled with fluorine-18. Synthesis, receptor binding and in vivo distribution of two non-steroidal estrogens as potential breast tumor imaging agents.

M. Welch, J. Katzenellenbogen, K. Bergmann, 1994, Nuclear medicine and biology.

Blocking estrogen signaling after the hormone: pyrimidine-core inhibitors of estrogen receptor-coactivator binding.

A. Parent, J. Katzenellenbogen, J. R. Gunther, 2008, Journal of medicinal chemistry.

Bromination from the macroscopic level to the tracer radiochemical level: (76)Br radiolabeling of aromatic compounds via electrophilic substitution.

Jason S. Lewis, M. Welch, J. Katzenellenbogen, 2009, Bioconjugate chemistry.

16 alpha-[77Br]bromo-11 beta-methoxyestradiol-17 beta: a gamma-emitting estrogen imaging agent with high uptake and retention by target organs.

M. Welch, J. Katzenellenbogen, K. Carlson, 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Erratum: Preparation and evaluation of 17-ethynyl-substituted 16α-[18F]fluoroestradiols: selective receptor-based PET imaging agents (Nuclear Medicine and Biology - International Journal of Radiation Applications and instrumentation Part B (Vol.nr. 19) (363-374))

M. Welch, M. Pomper, J. Katzenellenbogen, 1992 .

An Efficient Route for the Preparation of a 21-Fluoro Progestin-16α,17α-Dioxolane, a High-Affinity Ligand for PET Imaging of the Progesterone Receptor

J. Katzenellenbogen, Wang Mao, D. Vijaykumar, 2002 .

Fluorine-18-labeled progestin ketals: synthesis and target tissue uptake selectivity of potential imaging agents for receptor-positive breast tumors.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993, Journal of medicinal chemistry.

16 alpha-[77Br]bromoestradiol-17 beta: a high specific-activity, gamma-emitting tracer with uptake in rat uterus and uterus and induced mammary tumors.

M. Welch, J. Katzenellenbogen, S. G. Senderoff, 1981, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

16β-[18F]fluoromoxestrol : a potent, metabolically stable positron emission tomography imaging agent for estrogen receptor positive human breast tumors

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993 .

Fluorine-18-labeled progestin 16 alpha, 17 alpha-dioxolanes: development of high-affinity ligands for the progesterone receptor with high in vivo target site selectivity.

M. Welch, J. Katzenellenbogen, B. Buckman, 1995, Journal of medicinal chemistry.

Ligand Accessibility and Bioactivity of a Hormone-Dendrimer Conjugate Depend on pH and pH History.

B. Katzenellenbogen, J. Katzenellenbogen, S. Granick, 2015, Journal of the American Chemical Society.

Steroid Hormone Receptors as Targets for Diagnostic Imaging

M. Welch, J. Katzenellenbogen, J. B. Downer, 1996 .

Synthesis of C-6 fluoroandrogens: Evaluation of ligands for tumor receptor imaging

J. Katzenellenbogen, Y. Choe, 1995, Steroids.

20-[18F]fluoromibolerone, a positron-emitting radiotracer for androgen receptors: synthesis and tissue distribution studies.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Fluorinated androgens and progestins: molecular probes for androgen and progesterone receptors with potential use in positron emission tomography.

J. Katzenellenbogen, S. Brandes, 1987, Molecular pharmacology.

Fundamental considerations in the design of fluorine-18 labeled progestins and androgens as imaging agents for receptor-positive tumors of the breast and prostate.

J. Katzenellenbogen, S. Brandes, 1988, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

The development of gamma-emitting hormone analogs as imaging agents for receptor-positive tumors.

J. Katzenellenbogen, 1981, Progress in clinical and biological research.

Extra-nuclear effects of estrogen on cortical bone in males require ERαAF-1

J. Katzenellenbogen, M. Lagerquist, S. Windahl, 2017, Journal of molecular endocrinology.

A mutant form of ERα associated with estrogen insensitivity affects the coupling between ligand binding and coactivator recruitment

R. Houtman, J. Katzenellenbogen, K. Korach, 2020, Science Signaling.

Estrogen platinum-diamine complexes: Preparation of a non-steroidal estrogen platinum—diamine complex labeled with platinum-191 and a study of its binding to the estrogen receptor in vitro and its tissue distribution in vivo

M. Welch, J. Katzenellenbogen, K. Carlson, 1992, The Journal of Steroid Biochemistry and Molecular Biology.

Nonsteroidal estrogens bearing acyl azide functions: potential electrophilic and photoaffinity labeling agents for the estrogen receptor

J. Katzenellenbogen, K. Carlson, K. Pinney, 1992, Steroids.

Extranuclear estrogen receptor-α stimulates NeuroD1 binding to the insulin promoter and favors insulin synthesis

B. Katzenellenbogen, J. Katzenellenbogen, K. Korach, 2010, Proceedings of the National Academy of Sciences.

The estrogen receptor: a structure-based approach to the design of new specific hormone-receptor combinations.

B. Katzenellenbogen, J. Katzenellenbogen, J. A. Thomas, 2001, Chemistry & biology.

Utilizing electrostatic interactions to facilitate F-18 radiolabeling of poly(amido)amine (PAMAM) dendrimers.

C. Dence, J. Katzenellenbogen, Sung Hoon Kim, 2014, Organic & biomolecular chemistry.

Studies using fluorescent tetrahydrochrysene estrogens for in situ visualization of the estrogen receptor in living cells.

J. Katzenellenbogen, K. Carlson, K. Hwang, 1995, Molecular endocrinology.

Non-nuclear estrogen receptor alpha activation in endothelium reduces cardiac ischemia-reperfusion injury in mice.

B. Katzenellenbogen, J. Katzenellenbogen, P. Shaul, 2017, Journal of molecular and cellular cardiology.

17β-Estradiol Dysregulates Innate Immune Responses to Pseudomonas aeruginosa Respiratory Infection and Is Modulated by Estrogen Receptor Antagonism

J. Katzenellenbogen, S. Brody, D. Greenberg, 2017, Infection and Immunity.

Studies on the uterine, cytoplasmic estrogen binding protein. Thermal stability and ligand dissociation rate. An assay of empty and filled sites by exchange.

J. Katzenellenbogen, K. Carlson, H. J. Johnson, 1973, Biochemistry.

Corrigendum: NFκB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses

B. Katzenellenbogen, A. Joachimiak, J. Nowak, 2008 .

A comparative study of the selectivity and efficiency of target tissue uptake of five tritium-labeled androgens in the rat.

J. Katzenellenbogen, K. Carlson, 1990, Journal of steroid biochemistry.

FOXM1 regulates glycolysis and energy production in multiple myeloma

B. Katzenellenbogen, F. Zhan, P. Hari, 2022, Oncogene.

Characterization of the biological roles of the estrogen receptors, ERalpha and ERbeta, in estrogen target tissues in vivo through the use of an ERalpha-selective ligand.

B. Katzenellenbogen, J. Katzenellenbogen, H. Harris, 2002, Endocrinology.

Selective .gamma. alkylation of dienolate anions derived from .alpha.,.beta.-unsaturated acids. Applications to the synthesis of isoprenoid olefins

J. Katzenellenbogen, Ann L. Crumrine, 1976 .

Homodimeric and heterodimeric bis(amino thiol) oxometal complexes with rhenium(V) and technetium(V). Control of heterodimeric complex formation and an approach to metal complexes that mimic steroid hormones.

M. Welch, J. Katzenellenbogen, J. O’Neil, 1994, Journal of medicinal chemistry.

Biological activity and receptor binding of a strongly interacting estrogen in human breast cancer cells.

B. Katzenellenbogen, J. Katzenellenbogen, G. Reiner, 1984, Cancer research.

Tethered indoles as functionalizable ligands for the estrogen receptor.

Bridget G. Trogden, J. Katzenellenbogen, Sung Hoon Kim, 2009, Bioorganic & medicinal chemistry letters.

Dual-mechanism estrogen receptor inhibitors

B. Katzenellenbogen, J. Nwachukwu, S. Srinivasan, 2021, Proceedings of the National Academy of Sciences.

Design, Synthesis, and Conformational Analysis of a Proposed Type I β-Turn Mimic.

J. Katzenellenbogen, B. Fink, P. Kym, 1998 .

Directed evolution of specific receptor-ligand pairs for use in the creation of gene switches.

Huimin Zhao, Zhilei Chen, Karuppiah Chockalingam, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Selective Nonnuclear Estrogen Receptor Activation Decreases Stroke Severity and Promotes Functional Recovery in Female Mice.

Cody W. Whoolery, B. Katzenellenbogen, E. Plautz, 2018, Endocrinology.

Binding specificity of rat alpha-fetoprotein for a series of estrogen derivatives: studies using equilibrium and nonequilibrium binding techniques.

J. Katzenellenbogen, D. Payne, 1979, Endocrinology.

Genome-Wide Dynamics of Chromatin Binding of Estrogen Receptors (cid:1) and (cid:2) : Mutual Restriction and Competitive Site Selection

B. Katzenellenbogen, E. Liu, Y. Lee, 2009 .

Estrogen Receptors (cid:1) and (cid:2) as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding

B. Komm, B. Katzenellenbogen, J. Katzenellenbogen, 2008 .

Structure-guided optimization of estrogen receptor binding affinity and antagonist potency of pyrazolopyrimidines with basic side chains.

B. Katzenellenbogen, A. Joachimiak, J. Katzenellenbogen, 2007, Journal of medicinal chemistry.

NCA 16 alpha-[18F]fluoroestradiol-17 beta: the effect of reaction vessel on fluorine-18 resolubilization, product yield, and effective specific activity.

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1986, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

Dietary licorice root supplementation reduces diet-induced weight gain, lipid deposition, and hepatic steatosis in ovariectomized mice without stimulating reproductive tissues and mammary gland.

B. Katzenellenbogen, J. Katzenellenbogen, I. Khan, 2016, Molecular nutrition & food research.

Antagonists Selective for Estrogen Receptor (cid:1)

B. Katzenellenbogen, J. Katzenellenbogen, Shubin Sheng, 2002 .

Preparation of o-Fluorophenols from Nonaromatic Precursors: Mechanistic Considerations for Adaptation to Fluorine-18 Radiolabeling.

J. Katzenellenbogen, C. Mayne, N. Yasui, 2015, Organic letters.

Preliminary evaluation of a novel 18F-labeled PARP-1 ligand for PET imaging of PARP-1 expression in prostate cancer.

J. Katzenellenbogen, Sung Hoon Kim, Jinbin Xu, 2018, Nuclear medicine and biology.

Assessment of 21 8 F ] Fluoro-1 • 6 a-Ethyl-19-Norprogesterone a Positron-Emitting Radiopharmaceutical for the Detection of Progestin Receptors in Human Breast Carcinomas

M. Welch, M. Pomper, J. Katzenellenbogen, 2008 .

1,2-Diarylindano[a]indane: A molecule with skewed, cofacially disposed aromatic moieties and a long C-C single bond

Scott R. Wilson, J. Katzenellenbogen, G. Anstead, 1991 .

Imidoyl dichlorides as new reagents for the rapid formation of 2-aminobenzimidazoles and related azoles.

Julie A. Pollock, J. Katzenellenbogen, Sung Hoon Kim, 2015, Tetrahedron letters.

Extranuclear Actions of the Androgen Receptor Enhance Glucose-Stimulated Insulin Secretion in the Male.

B. Wicksteed, J. Katzenellenbogen, Hongju Wu, 2016, Cell metabolism.

Protease-activated "prodrugs" for cancer chemotherapy.

J. Katzenellenbogen, M. Weber, P. Chakravarty, 1980, Proceedings of the National Academy of Sciences of the United States of America.

Differential Actions of Estrogen Receptor α and β via Non-Genomic Signaling in Human Prostate Stem and Progenitor Cells.

J. Katzenellenbogen, G. Prins, Sung Hoon Kim, 2019, Endocrinology.

The tissue-specific effects of different 17β-estradiol doses reveal the key sensitizing role of AF1 domain in ERα activity

B. Katzenellenbogen, J. Katzenellenbogen, C. Ohlsson, 2020, Molecular and Cellular Endocrinology.

Plasmin-activated prodrugs for cancer chemotherapy. 2. Synthesis and biological activity of peptidyl derivatives of doxorubicin.

J. Katzenellenbogen, M. Weber, P. Chakravarty, 1983, Journal of medicinal chemistry.

Factors affecting the target site uptake selectivity of estrogen radiopharmaceuticals: serum binding and endogenous estrogens.

M. Welch, J. Katzenellenbogen, K. Carlson, 1983, Journal of steroid biochemistry.

Differential effects of estrogens in tissues: a comparison of estrogen receptor in rabbit uterus and vagina.

J. Katzenellenbogen, D. Payne, 1980, Endocrinology.

Synthesis and biological evaluation of guanylhydrazone coactivator binding inhibitors for the estrogen receptor.

J. Katzenellenbogen, Andrew L. LaFrate, K. Carlson, 2008, Bioorganic & Medicinal Chemistry.

21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone: synthesis and target tissue selective uptake of a progestin receptor based radiotracer for positron emission tomography.

M. Welch, M. Pomper, J. Katzenellenbogen, 1988, Journal of medicinal chemistry.

Receptor-binding radiopharmaceuticals for imaging breast tumors: estrogen-receptor interactions and selectivity of tissue uptake of halogenated estrogen analogs.

J. Katzenellenbogen, K. Carlson, D. Heiman, 1980, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

The Effects of the Phytoestrogen, Coumestrol, on Gonadotropin‐Releasing Hormone (GnRH) mRNA Expression in GT1‐7 GnRH Neurones

B. Katzenellenbogen, J. Katzenellenbogen, D. Sugden, 2003, Journal of neuroendocrinology.

International Union of Pharmacology. LXIV. Estrogen Receptors

V. Craig Jordan, John A. Katzenellenbogen, Karin Dahlman-Wright, 2006, Pharmacological Reviews.

Cyclic Ketoximes as Estrogen Receptor β Selective Agonists

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2016, ChemMedChem.

Deconstructing estradiol: removal of B-ring generates compounds which are potent and subtype-selective estrogen receptor agonists.

J. Katzenellenbogen, K. Carlson, Y. Qian, 2009, Bioorganic & medicinal chemistry letters.

Acylamino boronic acids and difluoroborane analogues of amino acids: potent inhibitors of chymotrypsin and elastase.

J. Katzenellenbogen, D. Kinder, 1985, Journal of medicinal chemistry.

Iodohexestrols. I. Synthesis and photoreactivity of iodinated hexestrol derivatives.

J. Katzenellenbogen, H. Hsiung, 1975, Biochemistry.

Reagents for photoaffinity labeling of estrogen binding proteins. Synthesis of some azide and diazo derivatives of estradiol, estrone, and hexestrol.

J. Katzenellenbogen, H. J. Johnson, H. N. Myers, 1973, The Journal of organic chemistry.

Design of pathway preferential estrogens that provide beneficial metabolic and vascular effects without stimulating reproductive tissues

B. Katzenellenbogen, J. Katzenellenbogen, K. Korach, 2016, Science Signaling.

Stereospecific total synthesis of the dl-C18 Cecropia juvenile hormone

E. Corey, B. W. Erickson, J. Katzenellenbogen, 1968 .

Multiple Beneficial Roles of Repressor of Estrogen Receptor Activity (REA) in Suppressing the Progression of Endometriosis.

Robert N. Taylor, B. Katzenellenbogen, J. Katzenellenbogen, 2016, Endocrinology.

Facile nucleophilic fluorination reactions using tert-alcohols as a reaction medium: significantly enhanced reactivity of alkali metal fluorides and improved selectivity.

J. Katzenellenbogen, Hwan-Jeong Jeong, M. Sohn, 2008, The Journal of organic chemistry.

Scope and limitations of a rapid radiobromination technique

M. Welch, J. Katzenellenbogen, S. G. Senderoff, 1981 .

Antagonists selective for estrogen receptor alpha.

B. Katzenellenbogen, J. Katzenellenbogen, Shubin Sheng, 2002, Endocrinology.

N 3 fluorine 18 fluoropropylspiperone the preferred fluorine 18 labeled spiperone analog for positron emission tomographic studies of the dopamine receptor

C. Dence, M. Welch, J. Perlmutter, 1988 .

New 1,1-diarylethylene FOXM1 inhibitors potently reduce intracellular FOXM1 and suppress high-grade serous ovarian carcinoma cell viability

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2022 .

Contrasting activities of estrogen receptor beta isoforms in triple negative breast cancer

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2020, Breast Cancer Research and Treatment.

Exploring the Structural Compliancy versus Specificity of the Estrogen Receptor Using Isomeric Three-Dimensional Ligands.

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2017, ACS chemical biology.

Tamoxifen antiestrogens. A comparison of the activity, pharmacokinetics, and metabolic activation of the cis and trans isomers of tamoxifen.

B. Katzenellenbogen, J. Katzenellenbogen, E. Rorke, 1982, Journal of steroid biochemistry.

Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling.

B. Katzenellenbogen, J. Katzenellenbogen, Micha Feigin-Almon, 2022, Science advances.

Selective Human Estrogen Receptor Partial Agonists (ShERPAs) for Tamoxifen-Resistant Breast Cancer.

J. Katzenellenbogen, G. Thatcher, D. Tonetti, 2016, Journal of medicinal chemistry.

A Set of Time-Resolved Fluorescence Resonance Energy Transfer Assays for the Discovery of Inhibitors of Estrogen Receptor-Coactivator Binding

R. Dingledine, J. Katzenellenbogen, H. Fu, 2009, Journal of biomolecular screening.

Acyclic amides as estrogen receptor ligands: synthesis, binding, activity and receptor interaction.

B. Katzenellenbogen, J. Katzenellenbogen, S. Stauffer, 2000, Bioorganic & medicinal chemistry.

The uterine and vascular actions of estetrol delineate a distinctive profile of estrogen receptor α modulation, uncoupling nuclear and membrane activation

B. Katzenellenbogen, J. Foidart, J. Katzenellenbogen, 2014, EMBO molecular medicine.

π–π Interaction Energies as Determinants of the Photodimerization of Mono-, Di-, and Triazastilbenes

A. Parent, J. Katzenellenbogen, D. Ess, 2014, The Journal of organic chemistry.

Synthesis of no-carrier-added N-([18F]fluoroalkyl)spiperone derivatives.

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1986, International journal of radiation applications and instrumentation. Part A, Applied radiation and isotopes.

Biomedicine. Defining the "S" in SERMs.

B. Katzenellenbogen, J. Katzenellenbogen, 2002, Science.

Metabolite ligands of estrogen receptor-beta reduce primate coronary hyperreactivity.

B. Katzenellenbogen, S. Oparil, J. Katzenellenbogen, 2006, American journal of physiology. Heart and circulatory physiology.

Synthesis of novel arylpyrazolo corticosteroids as potential ligands for imaging brain glucocorticoid receptors

J. Katzenellenbogen, K. Carlson, F. Wüst, 2003, Steroids.

5,6,11,12-Tetrahydrochrysenes: synthesis of rigid stilbene systems designed to be fluorescent ligands for the estrogen receptor

J. Katzenellenbogen, J. O’Neil, K. Hwang, 1992 .

Tripartite steroid hormone receptor pharmacology: interaction with multiple effector sites as a basis for the cell- and promoter-specific action of these hormones.

B. Katzenellenbogen, J. Katzenellenbogen, B. O’Malley, 1996, Molecular endocrinology.

Raloxifene and ICI182,780 increase estrogen receptor-alpha association with a nuclear compartment via overlapping sets of hydrophobic amino acids in activation function 2 helix 12.

M. Lupien, J. Katzenellenbogen, S. Mader, 2007, Molecular endocrinology.

AROMATIC FLUORINATION BY SILVER-ION PROMOTED DECOMPOSITION OF ARYL DIAZO SULFIDES : EFFICIENT UTILIZATION OF SUBSTOICHIOMETRIC LEVELS OF FLUORIDE ION

J. Katzenellenbogen, S. Haroutounian, J. P. Dizio, 1991 .

gem-Difluoro Compounds: A Convenient Preparation from Ketones and Aldehydes by Halogen Fluoride Treatment of 1,3-Dithiolanes.

J. Katzenellenbogen, Susan C. Sondej, 1987 .

gem-Difluoro compounds: a convenient preparation from ketones and aldehydes by halogen fluoride treatment of 1,3-dithiolanes

J. Katzenellenbogen, Susan C. Sondej, 1986 .

Halofluorination of olefins: elucidation of reaction characteristics and applications in labeling with the positron-emitting radionuclide fluorine-18

M. Welch, J. Katzenellenbogen, D. Kiesewetter, 1986 .

4′-Hydroxystyryldiazines: Synthesis and fluorescence properties

J. Katzenellenbogen, S. Haroutounian, 1995 .

Synthesis of 2-[18F]Fluoroestradiol, a Potential Diagnostic Imaging Agent for Breast Cancer: Strategies to Achieve Nucleophilic Substitution of an Electron-Rich Aromatic Ring with [18F]F-

M. Welch, E. Hostetler, J. Katzenellenbogen, 1999 .

Methyl hypofluorite in the synthesis of 16-methoxyestradiol stereoisomers

M. Welch, J. Katzenellenbogen, D. D'avignon, 1998, Steroids.

Synthesis of 16-fluoroestrogens by unusually facile fluoride ion displacement reactions: prospects for the preparation of fluorine-18 labeled estrogens

M. Welch, J. Katzenellenbogen, D. Kiesewetter, 1984 .

Synthesis of 16-fluoroestrogens by unusually facile fluoride ion displacement reactions: prospects for the preparation of fluorine-18 labeled estrogens

M. Welch, J. Katzenellenbogen, D. Kiesewetter, 1984 .

A convenient method for the preparation of highly substituted pyrimidines: Synthesis of tri‐ and tetra‐subsituted pyrimidines from 1,3‐dicarbonyl compounds and N,N,N‐tris‐(trimethylsilyl)amidines

J. Katzenellenbogen, Usha Ghosh, 2002 .

AROMATIC FLUORINATIONS SUITABLE FOR FLUORINE‐18 LABELING OF ESTROGENS

J. Katzenellenbogen, M. Kilbourn, J. Ng, 1981 .

Tetrabutylammonium fluoride-induced conversion of tresylates to mesylates

J. Katzenellenbogen, Seong Choe Yearn, 1993 .

Pyrazole ligands: structure-affinity/activity relationships and estrogen receptor-alpha-selective agonists.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2000, Journal of medicinal chemistry.

Regioselective synthesis of 1,3,5-triaryl-4-alkylpyrazoles: novel ligands for the estrogen receptor.

J. Katzenellenbogen, Y. Huang, Ying R. Huang, 2000, Organic letters.

Silicon-directed selective gamma substitution of an α,β-unsaturated ester

J. Katzenellenbogen, P. Albaugh-Robertson, 1982 .

Selective .gamma. alkylation of copper enolates derived from .alpha.,.beta.-unsaturated acids: factors affecting scope and regio- and stereoselectivity

J. Katzenellenbogen, Patricia M. Savu, 1981 .

Stereoselective method for the synthesis of both olefinic isomers from a single precursor. Conjugate reduction of .alpha.,.beta.-unsaturated epoxides

R. S. Lenox, J. Katzenellenbogen, 1973 .

Structural characterization of a subtype-selective ligand reveals a novel mode of estrogen receptor antagonism

David A. Agard, John A. Katzenellenbogen, Andrew K. Shiau, 2002, Nature Structural Biology.

Stereoselectivity of the rearrangement of allyl siloxyvinyl ethers. Highly stereoselective synthesis of a diol found in the pheromonal secretion of the queen butterfly

J. Katzenellenbogen, K. Christy, 1974 .

Analysis of the interaction of haloenol lactone suicide substrates with .alpha.-chymotrypsin using computer graphics and molecular mechanics

G. Marshall, J. Katzenellenbogen, S. Daniels, 1985 .

Preparation of hexahydrobenzo[f]isoquinolines using a vinylogous pictet-spengler cyclization.

J. Katzenellenbogen, R. Cesati, 2000, Organic letters.

Isocoumarins as estrogen receptor beta selective ligands: Isomers of isoflavone phytoestrogens and their metabolites.

Fabio Stossi, F. Stossi, B. Katzenellenbogen, 2005, Bioorganic & medicinal chemistry.

Synthesis of five-membered halo enol lactone analogs of .alpha.-amino acids: potential protease suicide substrates

J. Katzenellenbogen, M. Sofia, P. Chakravarty, 1983 .

Synthesis of halo enol lactones. Mechanism-based inactivators of serine proteases

J. Katzenellenbogen, G. Krafft, 1981 .

Enol lactone inhibitors of serine proteases. The effect of regiochemistry on the inactivation behavior of phenyl-substituted (halomethylene)tetra- and -dihydrofuranones and (halomethylene)tetrahydropyranones toward alpha-chymotrypsin: stable acyl enzyme intermediate.

J. Katzenellenbogen, M. Sofia, 1986, Journal of medicinal chemistry.

3-(Acylamido)-4-phenyl-6(E)-(iodomethylidene)tetrahydro-2-pyranones. Synthesis of novel amino acid analogues

J. Katzenellenbogen, M. Sofia, 1985 .

Synthesis of halo enol lactones. Mechanism-based inactivators of serine proteases

J. Katzenellenbogen, G. Krafft, 1981 .

An efficient synthesis of .gamma.-methylene-.gamma.-butyrolactone (.alpha.'-angelicalactone). Application to the synthesis of deoxyobtusilactone and deoxyisoobtusilactone

J. Katzenellenbogen, R. A. Amos, 1978 .

2,3-Diarylindenes and 2,3-diarylindenones: synthesis, molecular structure, photochemistry, estrogen receptor binding affinity, and comparisons with related triarylethylenes.

J. Katzenellenbogen, S. R. Wilson, G. Anstead, 1988, Journal of medicinal chemistry.

Stereoselective Z- and E-bromoenol lactonization of alkynoic acids

J. Katzenellenbogen, W. Dai, 1991 .

Novel structural templates for estrogen-receptor ligands and prospects for combinatorial synthesis of estrogens.

J. Katzenellenbogen, B. Fink, D. Mortensen, 1999, Chemistry & biology.

Highly Selective Salicylketoxime-Based Estrogen Receptor β Agonists Display Antiproliferative Activities in a Glioma Model

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2015, Journal of medicinal chemistry.

Estrogen receptor β ligands: Recent advances and biomedical applications

Marco Macchia, Filippo Minutolo, B. Katzenellenbogen, 2011, Medicinal research reviews.

Guanidinophenyl-substituted enol lactones as selective, mechanism-based inhibitors of trypsin-like serine proteases.

J. Katzenellenbogen, R. Rai, 1992, Journal of medicinal chemistry.

Synthesis of proline-valine pseudodipeptide enol lactones, serine protease inhibitors

J. Katzenellenbogen, P. Reed, 1991 .

Diaryl-dialkyl-substituted pyrazoles: regioselective synthesis and binding affinity for the estrogen receptor.

J. Katzenellenbogen, Alice L. Rodriguez, G. Nishiguchi, 2002, Bioorganic & medicinal chemistry letters.

Pyrazolo[1,5-a]pyrimidines: estrogen receptor ligands possessing estrogen receptor beta antagonist activity.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2004, Journal of medicinal chemistry.

Ab initio calculations on N-methylmethanesulfonamide and methyl methanesulfonate for the development of force field torsional parameters and their use in the conformational analysis of some novel estrogens

J. Katzenellenbogen, J. Golab, R. Bindal, 1990 .

Synthesis of analogs of 2-methoxyestradiol with enhanced inhibitory effects on tubulin polymerization and cancer cell growth.

Y. P. Sachdeva, J. Katzenellenbogen, M. Cushman, 1997, Journal of medicinal chemistry.

Synthesis, antitubulin and antimitotic activity, and cytotoxicity of analogs of 2-methoxyestradiol, an endogenous mammalian metabolite of estradiol that inhibits tubulin polymerization by binding to the colchicine binding site.

J. Katzenellenbogen, M. Cushman, E. Hamel, 1995, Journal of medicinal chemistry.

Thiophene-core estrogen receptor ligands having superagonist activity.

J. Nwachukwu, S. Srinivasan, J. Katzenellenbogen, 2013, Journal of medicinal chemistry.

Four-Coordinate Dimethylgallium Compounds Vary in Stability toward Hydrolysis

J. Katzenellenbogen, R. Chesnut, C. Cutler, 1998 .

Adamantyl Antiestrogens with Novel Side Chains Reveal a Spectrum of Activities in Suppressing Estrogen Receptor Mediated Activities in Breast Cancer Cells.

B. Katzenellenbogen, S. Srinivasan, J. Katzenellenbogen, 2017, Journal of medicinal chemistry.

Stereoselectivity in the reduction of aliphatic .alpha.-ketols with aluminum hydride reagents

J. Katzenellenbogen, S. Bowlus, 1973 .

Aluminum hydride reduction of .alpha.-ketols. II. Additional evidence for conformational flexibility in the transition state

J. Katzenellenbogen, S. Bowlus, 1974 .

Heterodimeric Bis(amino thiol) Complexes of Oxorhenium(V) That Mimic the Structure of Steroid Hormones. Synthesis and Stereochemical Issues.

J. Katzenellenbogen, D. Chi, R. K. Hom, 1996, The Journal of organic chemistry.

Preparation and structural characterization of monoamine-monoamide bis(thiol) oxo complexes of technetium(V) and rhenium(V)

J. Katzenellenbogen, J. O’Neil, S. R. Wilson, 1994 .

Selective formation of heterodimeric bis-bidentate aminothiol-oxometal complexes or rhenium(V)

J. Katzenellenbogen, D. Chi, 1993 .

Pyrazolo[1,5-a]pyrimidines as estrogen receptor ligands: defining the orientation of a novel heterocyclic core.

J. Katzenellenbogen, K. Carlson, Dennis R. Compton, 2004, Bioorganic & medicinal chemistry letters.

New stereospecific synthesis of trisubstituted olefins. Stereospecific synthesis of farnesol

E. Corey, J. Katzenellenbogen, G. Posner, 1967 .

Stereospecific synthesis of trisubstituted and tetrasubstituted olefins. Conjugate addition of dialkylcopper-lithium reagents to .alpha.,.beta.-acetylenic esters

E. Corey, J. Katzenellenbogen, 1969 .

Specific labeling of zinc finger proteins using noncanonical amino acids and copper-free click chemistry.

J. Katzenellenbogen, C. Schroeder, Sung Hoon Kim, 2012, Bioconjugate chemistry.

Beta-substituted beta-phenylpropionyl chymotrypsins. Structural and stereochemical features in stable acyl enzymes.

J. Katzenellenbogen, P. Reed, 1991, Journal of medicinal chemistry.

Stereoselective Z‐ and E‐Bromo Enol Lactonization of Alkynoic Acids.

J. Katzenellenbogen, W. Dai, 1992 .

Comparative QSAR analysis of estrogen receptor ligands.

C. Hansch, J. Katzenellenbogen, R. Garg, 1999, Chemical reviews.

Total synthesis of dl-sirenin

E. Corey, J. Katzenellenbogen, K. Achiwa, 1969 .

Design, Synthesis, and Conformational Analysis of a Proposed Type I β-Turn Mimic

John A. Katzenellenbogen, J. Katzenellenbogen, B. Fink, 1998 .

Ligands for the estrogen receptor, containing cyclopentadienyltricarbonylrhenium units.

J. Katzenellenbogen, T. W. Spradau, 1998, Bioorganic & medicinal chemistry letters.

2-Arylindenes and 2-arylindenones: Synthesis of probes to study the binding orientation of unsymmetrical nonsteroidal ligands to the estrogen receptor

J. Katzenellenbogen, G. Anstead, C. S. Peterson, 1989 .

Convenient one-pot synthesis of 2,2-bis-(4-hydroxyphenyl)-cyclopentanone.

J. Katzenellenbogen, J. Seo, D. Chi, 2008, The Journal of organic chemistry.

Estrogenic diazenes: heterocyclic non-steroidal estrogens of unusual structure with selectivity for estrogen receptor subtypes.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2003, Bioorganic & medicinal chemistry.

Ligand-binding dynamics rewire cellular signaling via Estrogen Receptor-α

Travis S. Hughes, Douglas J. Kojetin, John A. Katzenellenbogen, 2013, Nature chemical biology.

Coupling of Receptor Conformation and Ligand Orientation Determine Graded Activity

Min Zhao, Paul D. Adams, Pavel V. Afonine, 2010, Nature chemical biology.

NFkappaB selectivity of estrogen receptor ligands revealed by comparative crystallographic analyses.

B. Katzenellenbogen, J. Nowak, J. Katzenellenbogen, 2008, Nature chemical biology.

Indazole estrogens: highly selective ligands for the estrogen receptor beta.

Fabio Stossi, F. Stossi, B. Katzenellenbogen, 2005, Journal of medicinal chemistry.

A Polymer-Supported Phosphazine as a Stable and Practical Reagent in the Three-Component Synthesis of Substituted (Cyclopentadienyl)tricarbonylrhenium Complexes.

J. Katzenellenbogen, F. Minutolo, 1999, Angewandte Chemie.

Bicyclic core estrogens as full antagonists: synthesis, biological evaluation and structure-activity relationships of estrogen receptor ligands based on bridged oxabicyclic core arylsulfonamides.

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, Organic & biomolecular chemistry.

Generation of allyllithium reagents by lithium-tetrahydrofuran reduction of allylic mesitoates. New procedure for selective allylic cross coupling and allylcarbinol synthesis

R. S. Lenox, J. Katzenellenbogen, 1973 .

Improved synthesis of 2-methyl-6-methylene-2,7-octadien-4-ol, a pheromone of Ips paraconfusus, and an alternative synthesis of the intermediate, 2-bromomethyl-1,3-butadiene

R. S. Lenox, R. Silverstein, J. Katzenellenbogen, 1974 .

A Stereospecific Total Synthesis of α-Santalol

E. Corey, J. Katzenellenbogen, H. Kirst, 1970 .

Haloenol lactones. Potent enzyme-activated irreversible inhibitors for alpha-chymotrypsin.

J. Katzenellenbogen, S. Daniels, M. Sofia, 1983, The Journal of biological chemistry.

Novel cyclization mediated by organocopper reagents

E. Corey, J. Katzenellenbogen, 1972 .

Selective .gamma.-substitution of .alpha.,.beta.-unsaturated esters via .alpha.-trimethylsilyl .beta.,.gamma.-unsaturated esters

J. Katzenellenbogen, P. Albaugh-Robertson, 1983 .

Photosensitive Steroids as Probes of Estrogen Receptor Sites *

J. Katzenellenbogen, K. Carlson, M. Kilbourn, 1980, Annals of the New York Academy of Sciences.

CHARACTERIZATION OF THE SPECTROSCOPIC PROPERTIES OF A TETRAHYDROCHRYSENE SYSTEM CONTAINING A RIGIDIFIED HYDROXYNITROSTILBENE CHROMOPHORE: AN INHERENTLY FLUORESCENT LIGAND DESIGNED FOR THE ESTROGEN RECEPTOR

J. Katzenellenbogen, K. Hwang, Greorgy M. Anstead, 1993, Photochemistry and photobiology.

THE EFFECT OF ACCEPTOR GROUP VARIATION ON THE SOLVATOCHROMISM OF DONOR‐ACCEPTOR FLUOROPHORES

J. Katzenellenbogen, K. Carlson, K. Hwang, 1993, Photochemistry and photobiology.

Reaction of copper enolates of esters with propargylic systems. Facile preparation of 3,4-dienoic esters, stereoselective rearrangement to (2E,4Z)- and (2E,4E)-dienoic esters, and stereoselective synthesis of a fragrance from the Bartlett pear

J. Katzenellenbogen, R. A. Amos, 1978 .

11 beta-methoxy-, 11 beta-ethyl- and 17 alpha-ethynyl-substituted 16 alpha-fluoroestradiols: receptor-based imaging agents with enhanced uptake efficiency and selectivity.

M. Welch, M. Pomper, J. Katzenellenbogen, 1990, Journal of medicinal chemistry.

Nonsteroidal estrogens: synthesis and estrogen receptor binding affinity of derivatives of (3R*,4S*)-3,4-bis(4-hydroxyphenyl)hexane (hexestrol) and (2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentane (norhexestrol) functionalized on the side chain.

J. Katzenellenbogen, S. Landvatter, 1982, Journal of medicinal chemistry.

A synthesis of 7α-substituted estradiols: synthesis and biological evaluation of a 7α-pentyl-substituted BODIPY fluorescent conjugate and a fluorine-18-labeled 7α-pentylestradiol analog

Scott R. Wilson, M. Welch, J. Katzenellenbogen, 1993, Steroids.

A selective, allylic cross-coupling reaction. The generation of allyllithium reagents by reduction of allyl mesitoates.

R. S. Lenox, J. Katzenellenbogen, 1972 .

Aryl cyclopentadienyl tricarbonyl rhenium complexes: novel ligands for the estrogen receptor with potential use as estrogen radiopharmaceuticals.

J. Katzenellenbogen, Alice L. Rodriguez, E. Mull, 2002, Bioorganic & medicinal chemistry.

Silicon-mediated synthesis of bibenzyl systems: synthesis of ring and side-chain functionalized hexestrol derivatives

J. Katzenellenbogen, Raju Mohan, 1984 .

Desmethylnafoxidine aziridine: an electrophilic affinity label for the estrogen receptor with high efficiency and selectivity.

J. Katzenellenbogen, D. Simpson, J. F. Elliston, 1987, Journal of steroid biochemistry.

Trifluoromethyl-substituted Δ3-imidazolines: Synthesis and reactivity

J. Katzenellenbogen, Christopher W. Derstine, David N. Smith, 1997 .

Expeditious synthesis of steroids containing a 2-methylsulfanyl-acetyl side chain as potential glucocorticoid receptor imaging agents

F. Wuest, J. Katzenellenbogen, K. Carlson, 2008, Steroids.

Technetium-99m-labeled receptor-specific small-molecule radiopharmaceuticals: recent developments and encouraging results.

J. Katzenellenbogen, R. K. Hom, 1997, Nuclear medicine and biology.

Fluorescence-based assay of estrogen receptor using 12-oxo-9(11)-dehydroestradiol-17 beta.

J. Katzenellenbogen, K. Carlson, H. Magdelenat, 1986, Analytical biochemistry.

Exploration of the bicyclo[3.3.1]nonane system as a template for the development of new ligands for the estrogen receptor.

J. Katzenellenbogen, K. Carlson, John A Katzenellenbogen, 2003, Bioorganic & medicinal chemistry letters.

The 2010 Philip S. Portoghese Medicinal Chemistry Lectureship: addressing the "core issue" in the design of estrogen receptor ligands.

J. Katzenellenbogen, John A Katzenellenbogen, 2011, Journal of medicinal chemistry.

Synthesis and NMR spectrum of [13C18]‐meso‐hexestrol, a fully carbon‐13 substituted ligand for NMR studies of the estrogen receptor

J. Katzenellenbogen, T. Härd, M. Kochanny, 1993 .

Crystal Structure of a Bis(amido)bis(thiolato)oxorhenium(V) Complex That Forms a Methanol-Solvated Salt with Calcium Extracted from Silica Gel

Scott R. Wilson, J. Katzenellenbogen, D. Chi, 1995 .

Azophilic addition of alkyllithium reagents to fluorenimines. The synthesis of secondary amines

J. Katzenellenbogen, W. Dai, R. Srinivasan, 1989 .

Technetium- and rhenium-labeled progestins: synthesis, receptor binding and in vivo distribution of an 11 beta-substituted progestin labeled with technetium-99 and rhenium-186.

M. Welch, J. Katzenellenbogen, K. Carlson, 1992, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Synthesis of a functionalized gallium(III) tripodyl complex

J. Katzenellenbogen, L. Luyt, 2001 .

Estradiol derivatives bearing sulfur-containing substituents at the 11beta or 7alpha positions: versatile reagents for the preparation of estrogen conjugates.

J. Katzenellenbogen, K. Carlson, G. Cabrera, 2004, Bioorganic & medicinal chemistry.

11 beta-substituted estradiol derivatives. 2. Potential carbon-11- and iodine-labeled probes for the estrogen receptor.

J. Katzenellenbogen, K. Carlson, E. Napolitano, 1995, Journal of medicinal chemistry.

11 beta-Substituted estradiol derivatives, potential high-affinity carbon-11-labeled probes for the estrogen receptor: a structure-affinity relationship study.

J. Katzenellenbogen, K. Carlson, E. Napolitano, 1995, Journal of medicinal chemistry.

The synthesis of 7α-methyl-substituted estrogens labeled with fluorine-18: potential breast tumor imaging agents

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1994, Steroids.

Derivatives of 4-styrylpyridines: Synthesis, estrogen receptor binding affinity, and photophysical properties

J. Katzenellenbogen, S. Haroutounian, A. Scribner, 1995, Steroids.

HYDROXYSTILBAZOLES AND HYDROXYAZAPHENANTHRENES: PHOTOCYCLIZATION AND FLUORESCENCE STUDIES

J. Katzenellenbogen, S. Haroutounian, 1988, Photochemistry and photobiology.

Synthesis of novel progestin-rhenium conjugates as potential ligands for the progesterone receptor.

J. Katzenellenbogen, H. Spies, B. Johannsen, 1999, Bioorganic & medicinal chemistry.

Synthesis and binding affinities of new 17α-substituted estradiol-rhenium “n+1” mixed-ligand and thioether-carbonyl complexes

J. Katzenellenbogen, K. Carlson, H. Spies, 1998, Steroids.

Synthesis of tetradentate bisamino-bisthiol complexes of oxorhenium(V) as structural mimics of steroids

J. Katzenellenbogen, Y. Sugano, 1996 .

Progestin radiopharmaceuticals labeled with technetium and rhenium: synthesis, binding affinity, and in vivo distribution of a new progestin N2S2-metal conjugate.

M. Welch, J. Katzenellenbogen, J. O’Neil, 1994, Bioconjugate chemistry.

Progestin-rhenium complexes: metal-labeled steroids with high receptor binding affinity, potential receptor-directed agents for diagnostic imaging or therapy.

J. Katzenellenbogen, A. Davison, A. G. Jones, 1991, Bioconjugate chemistry.

Three-Component Synthesis of Substituted η5-Cyclopentadienyltricarbonylrhenium Complexes: Scope, Limitations, and Mechanistic Interpretations

J. Katzenellenbogen, F. Minutolo, 1999 .

Preparation of Cyclopentadienyltricarbonylrhenium Complexes Using a Double Ligand-Transfer Reaction

J. Katzenellenbogen, T. W. Spradau, 1998 .

7alpha- and 17alpha-substituted estrogens containing tridentate tricarbonyl rhenium/technetium complexes: synthesis of estrogen receptor imaging agents and evaluation using microPET with technetium-94m.

Michael J Welch, M. Welch, J. Katzenellenbogen, 2003, Bioorganic & medicinal chemistry.

Hyperconjugative effects on carbon—Carbon bond lengths in molecular mechanics (MM4)

Scott R. Wilson, Norman L. Allinger, John A. Katzenellenbogen, 1996 .

AN EXPEDITIOUS ROUTE TO 7α-SUBSTITUTED ESTRADIOL DERIVATIVES

J. Katzenellenbogen, R. Tedesco, E. Napolitano, 1997 .

A trithiolate tripodal bifunctional ligand for the radiolabeling of peptides with gallium(III).

J. Katzenellenbogen, L. Luyt, 2002, Bioconjugate chemistry.

Preparation, receptor binding, and fluorescence properties of hexestrol-fluorophore conjugates: evaluation of site of attachment, fluorophore structure, and fluorophore-ligand spacing.

J. Katzenellenbogen, J. Zablocki, T. Fevig, 1987, Journal of medicinal chemistry.

Photoaffinity labels for estrogen binding proteins of rat uterus.

J. Katzenellenbogen, J A Katzenellenbogen, H J Johnson, 1973, Biochemistry.

Pyridyl-Cyclopentadiene Re(CO)(2) Complexes as a Compact Core Systems for SPECT Ligand Development.

J. Katzenellenbogen, N. Ackroyd, 2010, Organometallics.

Proline-valine pseudo peptide enol lactones. Effective and selective inhibitors of chymotrypsin and human leukocyte elastase.

J. Katzenellenbogen, P. Reed, 1991, The Journal of biological chemistry.

Phenol red in tissue culture media is a weak estrogen: implications concerning the study of estrogen-responsive cells in culture.

B. Katzenellenbogen, J. Katzenellenbogen, Y Berthois, 1986, Proceedings of the National Academy of Sciences of the United States of America.

Molecular mechanisms of estrogen action: selective ligands and receptor pharmacology

B. Katzenellenbogen, J. Katzenellenbogen, M. Montano, 2000, The Journal of Steroid Biochemistry and Molecular Biology.

Diethylstilbestrol and tetrahydrochrysenes are calcium channel blockers in human platelets: relationship to the stilbene pharmacophore.

J. Katzenellenbogen, P. Blackmore, Y. Dobrydneva, 2003, Thrombosis research.

Non-nuclear estrogen receptor alpha signaling promotes cardiovascular protection but not uterine or breast cancer growth in mice.

B. Katzenellenbogen, J. Katzenellenbogen, K. Korach, 2010, The Journal of clinical investigation.

Ketononestrol aziridine, an agonistic estrogen receptor affinity label: study of its bioactivity and estrogen receptor covalent labeling.

B. Katzenellenbogen, J. Katzenellenbogen, J. Zablocki, 1987, Endocrinology.

Identification of cysteine 530 as the covalent attachment site of an affinity-labeling estrogen (ketononestrol aziridine) and antiestrogen (tamoxifen aziridine) in the human estrogen receptor.

B. Katzenellenbogen, J. Katzenellenbogen, G. Greene, 1989, The Journal of biological chemistry.

CHRM1 is a Druggable Melanoma Target Whose Endogenous Activity is Determined by Inherited Genetic Variation in DOPA Production

In Young Lee, B. Katzenellenbogen, J. Katzenellenbogen, 2021, bioRxiv.

Estrogen receptor based imaging agents. 2. Synthesis and receptor binding affinity of side-chain halogenated hexestrol derivatives.

J. Katzenellenbogen, D. Heiman, R. Goswami, 1980, Journal of medicinal chemistry.

Affinity labeling of receptors for steroid and thyroid hormones.

B. Katzenellenbogen, J. Katzenellenbogen, 1984, Vitamins and hormones.

Estrogenic affinity labels: synthesis, irreversible receptor binding, and bioactivity of aziridine-substituted hexestrol derivatives.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1987, Journal of medicinal chemistry.

Efficient and highly selective covalent labeling of the estrogen receptor with [3H]tamoxifen aziridine.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1983, The Journal of biological chemistry.

Tamoxifen aziridines: effective inactivators of the estrogen receptor.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1981, Endocrinology.

Improved synthesis of 2-methyl-6-methylene-2,7-octadien-4-ol, a pheromone of Ips paraconfusus, and an alternative synthesis of the intermediate, 2-bromomethyl-1,3-butadiene

R. S. Lenox, R. Silverstein, J. Katzenellenbogen, 1974 .

Insect pheromone synthesis: new methodology.

J. Katzenellenbogen, 1976, Science.

Synthesis and Binding Affinities of Novel Re-Containing 7alpha-Substituted Estradiol Complexes: Models for Breast Cancer Imaging Agents.

J. Katzenellenbogen, M. Skaddan, F. Wüst, 1999, The Journal of organic chemistry.

Photoaffinity labeling of rat alpha-fetoprotein.

J. Katzenellenbogen, K. Carlson, D. Payne, 1980, The Journal of biological chemistry.

Binding of 16α-[18F]Fluoro-17β-estradiol to alphafetoprotein in Sprague-Dawley female rats affects blood levels

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1990 .

The capacity of the antiestrogen CI-628 to activate the estrogen receptor in vitro.

B. Katzenellenbogen, J. Katzenellenbogen, A. Notides, 1981, Endocrinology.

Anti-estrogen interaction with uterine estrogen receptors. Studies with a radiolabeled anti-estrogen (CI-628).

B. Katzenellenbogen, J. Katzenellenbogen, E. Ferguson, 1978, The Journal of biological chemistry.

Characterization of trypsin-treated forms of the estrogen receptor from rat and lamb uterus.

J. Katzenellenbogen, K. Carlson, L. H. Sun, 1977, Biochemistry.

Plasmin-activated prodrugs for cancer chemotherapy. 1. Synthesis and biological activity of peptidylacivicin and peptidylphenylenediamine mustard.

J. Katzenellenbogen, M. Weber, P. Chakravarty, 1983, Journal of medicinal chemistry.

Preclinical evaluation of fluorine-18-labeled androgen receptor ligands in baboons.

P. Cutler, M. Welch, J. Katzenellenbogen, 1996, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Respective role of membrane and nuclear estrogen receptor (ER) α in the mandible of growing mice: Implications for ERα modulation

B. Katzenellenbogen, J. Katzenellenbogen, A. Berdal, 2018, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

The quest for improving the management of breast cancer by functional imaging: The discovery and development of 16α-[18F]fluoroestradiol (FES), a PET radiotracer for the estrogen receptor, a historical review.

J. Katzenellenbogen, John A Katzenellenbogen, 2020, Nuclear medicine and biology.

Photoreactivity of some light-sensitive estrogen derivatives. Use of an exchange assay to determine their photointeraction with the rat uterine estrogen binding protein.

J. Katzenellenbogen, K. Carlson, H. J. Johnson, 1974, Biochemistry.

Bis(4-hydroxyphenyl)[2-(phenoxysulfonyl)phenyl]methane: isolation and structure elucidation of a novel estrogen from commercial preparations of phenol red (phenolsulfonphthalein)

J. Katzenellenbogen, R. Bindal, R. D. Bindal, 1988, Journal of medicinal chemistry.

Trifluoromethyl-Substituted Imidazolines: Novel Precursors of Trifluoromethyl Ketones Amenable to Peptide Synthesis

J. Katzenellenbogen, Christopher W. Derstine, A. D. N. Smith, 1996 .

Design of integrated fluorescent estrogens: The second donor effect on absorption, fluorescence, and ground-state molecular orbital properties of trans-4,4′-methoxynitrostilbene systems

J. Katzenellenbogen, G. Anstead, 1990 .

Trifluoromethyl-Substituted Imidazolines: Novel Precursors of Trifluoromethyl Ketones Amenable to Peptide Synthesis.

J. Katzenellenbogen, D. N. Smith, C. W. Derstine, 1997 .

Synthesis, estrogen receptor binding, and tissue distribution of [18F]fluorodoisynolic acids.

M. Welch, J. Katzenellenbogen, S. Jonson, 1997, Nuclear medicine and biology.

Reaction of lithium dialkylcuprates with acetoxy epoxides. Assessment of a method for nucleophilic .alpha.-alkylation of ketones

J. Katzenellenbogen, R. A. Amos, 1977 .

Chapter 23. Affinity Labeling of Hormone Binding Sites

J. Katzenellenbogen, 1974 .

Design of Integrated Fluorescent Estrogens: The Second Donor Effect on Absorption, Fluorescence, and Ground-State MO Properties of trans-4,4′-Methoxynitrostilbene Systems.

J. Katzenellenbogen, G. Anstead, 1990 .

Estrogen receptor based imaging agents. 1. Synthesis and receptor binding affinity of some aromatic and D-ring halogenated estrogens.

J. Katzenellenbogen, D. Heiman, S. G. Senderoff, 1980, Journal of medicinal chemistry.

Synthesis, binding affinity, and transcriptional activity of hydroxy- and methoxy-Substituted 3,4-Diarylsalicylaldoximes on estrogen receptors α and β

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2003 .

Integrative genomics of gene and metabolic regulation by estrogen receptors a and b , and their coregulators

B. Katzenellenbogen, E. Liu, J. Katzenellenbogen, 2013 .

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

B. Katzenellenbogen, E. Liu, J. Katzenellenbogen, 2013, Molecular systems biology.

Genome-wide dynamics of chromatin binding of estrogen receptors alpha and beta: mutual restriction and competitive site selection.

B. Katzenellenbogen, E. Liu, Y. Lee, 2010, Molecular endocrinology.

Nuclear and extranuclear pathway inputs in the regulation of global gene expression by estrogen receptors.

B. Komm, B. Katzenellenbogen, J. Katzenellenbogen, 2008, Molecular endocrinology.

A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.

B. Katzenellenbogen, S. Gambhir, J. Katzenellenbogen, 2008, Molecular endocrinology.

Estrogen Receptors (cid:1) and (cid:2) as Determinants of Gene Expression: Influence of Ligand, Dose, and Chromatin Binding

Barry Komm, B. Komm, B. Katzenellenbogen, 2008 .

Nongenotropic, Sex-Nonspecific Signaling through the Estrogen or Androgen Receptors Dissociation from Transcriptional Activity

B. Katzenellenbogen, P. Roberson, J. Katzenellenbogen, 2001, Cell.

Estrogen-occupied Estrogen Receptor Represses Cyclin G2 Gene Expression and Recruits a Repressor Complex at the Cyclin G2 Promoter*

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2006, Journal of Biological Chemistry.

Increase in chemokine CXCL1 by ERβ ligand treatment is a key mediator in promoting axon myelination

J. Katzenellenbogen, S. Tiwari-Woodruff, Sung Hoon Kim, 2018, Proceedings of the National Academy of Sciences.

REGULATION OF ESTROGEN RECEPTOR-ALPHA MEDIATED GENE EXPRESSION AND ENDOCRINE RESISTANCE THROUGH ESTROGEN RECEPTOR-ALPHA PHOSPHORYLATION AND MICRO-RNA IN BREAST CANCER BY KYURI KIM DISSERTATION Submitted in partial fulfillment of the requirements for the degree of Doctor of Philosophy in Molecular an

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2011 .

An ADIOL-ERβ-CtBP Transrepression Pathway Negatively Regulates Microglia-Mediated Inflammation

Andrew C. Li, C. Glass, J. Katzenellenbogen, 2011, Cell.

Minireview: Not picking pockets: nuclear receptor alternate-site modulators (NRAMs).

J. Katzenellenbogen, C. Mayne, T. Moore, 2010, Molecular endocrinology.

Kinase-specific phosphorylation of the estrogen receptor changes receptor interactions with ligand, deoxyribonucleic acid, and coregulators associated with alterations in estrogen and tamoxifen activity.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2006, Molecular endocrinology.

Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.

J. Katzenellenbogen, R. Hanson, P. T. Weiser, 2009, Organic letters.

Bicyclo[2.2.2]octanes: close structural mimics of the nuclear receptor-binding motif of steroid receptor coactivators.

J. Katzenellenbogen, Hai-Bing Zhou, M. Collins, 2007, Bioorganic & medicinal chemistry letters.

Transcription Regulation and Genome Rewiring Governing Sensitivity and Resistance to FOXM1 Inhibition in Breast Cancer

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2021, Cancers.

Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

Sarat Chandarlapaty, Christopher G Mayne, B. Katzenellenbogen, 2018, Nature Reviews Cancer.

Structural and Molecular Mechanisms of Cytokine-Mediated Endocrine Resistance in Human Breast Cancer Cells.

Xin-Qiu Yao, Barry J. Grant, Maayan Yakir, 2017, Molecular cell.

Preparation and evaluation of 17-ethynyl-substituted 16 alpha-[18F]fluoroestradiols: selective receptor-based PET imaging agents.

M. Welch, M. Pomper, J. Katzenellenbogen, 1992, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

(2R*, 3S*)-1-[18F]fluoro-2,3-bis(4-hydroxyphenyl)pentane [( 18F]fluoronor-hexestrol), a positron-emitting estrogen that shows highly-selective, receptor-mediated uptake by target tissues in vivo.

M. Welch, J. Katzenellenbogen, D. Kiesewetter, 1983, Life sciences.

Estrogen controls lipolysis by up-regulating alpha2A-adrenergic receptors directly in human adipose tissue through the estrogen receptor alpha. Implications for the female fat distribution.

J. Katzenellenbogen, B. Richelsen, K. Kristensen, 2004, The Journal of clinical endocrinology and metabolism.

Positron tomographic assessment of estrogen receptors in breast cancer: comparison with FDG-PET and in vitro receptor assays.

J E Mortimer, M J Welch, F Dehdashti, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Estrogen receptor alpha somatic mutations Y537S and D538G confer breast cancer endocrine resistance by stabilizing the activating function-2 binding conformation

Sarat Chandarlapaty, Emad Tajkhorshid, Patrick R Griffin, 2016, eLife.

Design, Synthesis, and Preclinical Characterization of the Selective Androgen Receptor Modulator (SARM) RAD140.

Gary Hattersley, Chris P. Miller, Hillary Herendeen, 2011, ACS medicinal chemistry letters.

Antiestrogens: studies using an in vitro estrogen-responsive uterine system.

B. Katzenellenbogen, J. Katzenellenbogen, 1973, Biochemical and biophysical research communications.

Estrogen and antiestrogen action: studies in reproductive target tissues and tumors.

B. Katzenellenbogen, J. Katzenellenbogen, T. Tatee, 1979, Advances in experimental medicine and biology.

Uptake of three [3H]progestins by target tissues in vivo: implications for the design of diagnostic imaging agents.

M. Pomper, J. Katzenellenbogen, K. Carlson, 1988, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Biological potency and uterine estrogen receptor interactions of the metabolites of the antiestrogens CI628 and U23,469.

B. Katzenellenbogen, J. Katzenellenbogen, E. Rorke, 1981, Endocrinology.

Interaction of a high affinity anti-estrogen (alpha-[4-pyrrolidinoethoxy]phenyl-4-hydroxy-alpha'-nitrostilbene, CI628M) with uterine estrogen receptors.

B. Katzenellenbogen, J. Katzenellenbogen, D. Robertson, 1981, The Journal of biological chemistry.

Stilbestrols and stilbestrol derivatives: Estrogenic potency and temporal relationships between estrogen receptor binding and uterine growth

B. Katzenellenbogen, J. Katzenellenbogen, N. Lan, 1978, Molecular and Cellular Endocrinology.

Non-estrogenic Xanthohumol Derivatives Mitigate Insulin Resistance and Cognitive Impairment in High-Fat Diet-induced Obese Mice

B. Katzenellenbogen, J. Raber, J. Katzenellenbogen, 2018, Scientific Reports.

Lipophilic impurities, not phenolsulfonphthalein, account for the estrogenic activity in commercial preparations of phenol red.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1988, Journal of steroid biochemistry.

Inhibiting androgen receptor nuclear entry in castration-resistant prostate cancer

A. Parent, Julie A. Pollock, J. Katzenellenbogen, 2016, Nature chemical biology.

Publisher Correction: Structural underpinnings of oestrogen receptor mutations in endocrine therapy resistance

B. Katzenellenbogen, S. Chandarlapaty, J. Katzenellenbogen, 2018, Nature Reviews Cancer.

Activation of ERα is necessary for estradiol's anorexigenic effect in female rats

B. Katzenellenbogen, J. Katzenellenbogen, J. Santollo, 2010, Hormones and Behavior.

A peptidyl derivative of [3H]aniline as a sensitive, stable, protease substrate.

J. Katzenellenbogen, M. Weber, D. Kohn, 1979, Analytical biochemistry.

Linkage Effects on Binding Affinity and Activation of GPR30 and Estrogen Receptors ERα/β with Tridentate Pyridin-2-yl Hydrazine Tricarbonyl−Re/99mTc(I) Chelates

T. Nayak, J. Katzenellenbogen, L. Sklar, 2006 .

Hormone-PAMAM dendrimer conjugates: polymer dynamics and tether structure affect ligand access to receptors.

J. Katzenellenbogen, Sung Hoon Kim, 2006, Angewandte Chemie.

Synthesis and evaluation of hexahydrochrysene and tetrahydrobenzofluorene ligands for the estrogen receptor.

J. Katzenellenbogen, S. R. Wilson, J A Katzenellenbogen, 2001, Bioorganic & medicinal chemistry letters.

Probing conformational changes in the estrogen receptor: evidence for a partially unfolded intermediate facilitating ligand binding and release.

J. Katzenellenbogen, J A Katzenellenbogen, A C Gee, 2001, Molecular endocrinology.

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β.

B. Katzenellenbogen, J. Katzenellenbogen, B. Fink, 1999, Endocrinology.

Determinants of Ligand Specificity of Estrogen Receptor-α: Estrogen versus Androgen Discrimination*

B. Katzenellenbogen, J. Katzenellenbogen, K. Ekena, 1998, The Journal of Biological Chemistry.

7α,11β-Disubstituted estrogens: Probes for the shape of the ligand binding pocket in the estrogen receptor

J. Katzenellenbogen, R. Tedesco, E. Napolitano, 1997 .

Estrogen Receptor Imaging Using Intrinsically Fluorescent Ligands

J. Katzenellenbogen, R. Miksicek, 1996 .

Donor-acceptor tetrahydrochrysenes, inherently fluorescent, high-affinity ligands for the estrogen receptor: binding and fluorescence characteristics and fluorometric assay of receptor.

J. Katzenellenbogen, K. Carlson, K. Hwang, 1992, Biochemistry.

5,6,11,12‐Tetrahydrochrysenes: Synthesis of Rigid Stilbene Systems Designed to be Fluorescent Ligands for the Estrogen Receptor.

J. Katzenellenbogen, J. O’Neil, K. Hwang, 1992 .

Selective Delivery of an Anticancer Drug with Aptamer-Functionalized Liposomes to Breast Cancer Cells in Vitro and in Vivo.

J. Katzenellenbogen, L. Dobrucki, Yi Lu, 2013, Journal of materials chemistry. B.

MMTV-PyMT and Derived Met-1 Mouse Mammary Tumor Cells as Models for Studying the Role of the Androgen Receptor in Triple-Negative Breast Cancer Progression

B. Katzenellenbogen, Julie A. Pollock, J. Katzenellenbogen, 2017, Hormones and Cancer.

Association of PET-based estradiol-challenge test for breast cancer progesterone receptors with response to endocrine therapy

J. Katzenellenbogen, B. Siegel, M. Naughton, 2021, Nature Communications.

Tumor receptor imaging: proceedings of the National Cancer Institute workshop, review of current work, and prospective for further investigations.

C. Osborne, R. Reba, R. Coleman, 1995, Clinical cancer research : an official journal of the American Association for Cancer Research.

Molecular characterization by mass spectrometry of the human estrogen receptor ligand-binding domain expressed in Escherichia coli.

J. Katzenellenbogen, K. Carlson, G. Greene, 1995, Molecular endocrinology.

Fluorescent Nanoconjugate Derivatives with Enhanced Photostability for Single Molecule Imaging.

J. Katzenellenbogen, Sung Hoon Kim, Charles M. Schroeder, 2015, Analytical chemistry.

Dendrimer probes for enhanced photostability and localization in fluorescence imaging.

J. Katzenellenbogen, M. Tanyeri, Sung Hoon Kim, 2013, Biophysical journal.

Long-Term Administration of Conjugated Estrogen and Bazedoxifene Decreased Murine Fecal β-Glucuronidase Activity Without Impacting Overall Microbiome Community

Michael J. Miller, J. Katzenellenbogen, L. Auvil, 2018, Scientific Reports.

Estrogenic effects of extracts from cabbage, fermented cabbage, and acidified brussels sprouts on growth and gene expression of estrogen-dependent human breast cancer (MCF-7) cells.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2000, Journal of agricultural and food chemistry.

Characterization of the pharmacophore properties of novel selective estrogen receptor downregulators (SERDs).

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2010, Journal of medicinal chemistry.

Ligand-induced changes in estrogen receptor conformation as measured by site-directed spin labeling.

J. Katzenellenbogen, K. Carlson, R. Belford, 2004, Biochemistry.

Molecular sensors of estrogen receptor conformations and dynamics.

J. Katzenellenbogen, K. Carlson, A. Tamrazi, 2003, Molecular endocrinology.

Estrogen receptor dimerization: ligand binding regulates dimer affinity and dimer dissociation rate.

J. Katzenellenbogen, K. Carlson, A. Tamrazi, 2002, Molecular endocrinology.

Conformational Changes and Coactivator Recruitment by Novel Ligands for Estrogen Receptor-α and Estrogen Receptor-β: Correlations with Biological Character and Distinct Differences among SRC Coactivator Family Members.

B. Katzenellenbogen, J. Katzenellenbogen, Jun Sun, 2000, Endocrinology.

Estrogen receptor subtype-selective ligands: asymmetric synthesis and biological evaluation of cis- and trans-5,11-dialkyl- 5,6,11, 12-tetrahydrochrysenes.

K E Carlson, B. Katzenellenbogen, J. Katzenellenbogen, 1999, Journal of medicinal chemistry.

Copper-Mediated Nucleophilic Radiobromination of Aryl Boron Precursors: Convenient Preparation of a Radiobrominated PARP-1 Inhibitor.

J. Katzenellenbogen, Thomas F Voller, W. Chu, 2018, Tetrahedron letters.

Identification of Toll-like receptor signaling inhibitors based on selective activation of hierarchically acting signaling proteins

Taosheng Chen, Julie A. Pollock, J. Katzenellenbogen, 2018, Science Signaling.

Facile geometric isomerization of phenolic non-steroidal estrogens and antiestrogens: limitations to the interpretation of experiments characterizing the activity of individual isomers.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1985, Journal of steroid biochemistry.

Triaryl Pyrazole Toll‐Like Receptor Signaling Inhibitors: Structure–Activity Relationships Governing Pan‐ and Selective Signaling Inhibitors

Julie A. Pollock, J. Katzenellenbogen, H. Häcker, 2018, ChemMedChem.

ANTIESTROGEN BASICITY‐ACTIVITY RELATIONSHIPS: A COMPARISON OF THE ESTROGEN RECEPTOR BINDING AND ANTIUTEROTROPHIC POTENCIES OF SEVERAL ANALOGS OF (Z)‐1,2‐DIPHENYL‐1‐(4‐(2‐(DIMETHYLAMINO)ETHOXY)PHENYL)‐1‐BUTENE (TAMOXIFEN, NOLVADEX) HAVING ALTERED BASICITY

B. Katzenellenbogen, J. Katzenellenbogen, D. Robertson, 1982 .

The SERM/SERD bazedoxifene disrupts ESR1 helix 12 to overcome acquired hormone resistance in breast cancer cells

S. Chandarlapaty, E. Tajkhorshid, J. Nwachukwu, 2018, bioRxiv.

Hydroxylated 2,3-diarylindenes: synthesis, estrogen receptor binding affinity, and binding orientation considerations.

J. Katzenellenbogen, G. Anstead, C. S. Peterson, 1989, Journal of steroid biochemistry.

Imaging progesterone receptor in breast tumors: synthesis and receptor binding affinity of fluoroalkyl-substituted analogues of tanaproget.

Christopher G Mayne, J. Katzenellenbogen, K. Carlson, 2010, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of ellipticine-estradiol conjugates.

J F Barrett, J. Katzenellenbogen, R. Devraj, 1996, Journal of medicinal chemistry.

PET Imaging Agents (FES, FFNP, and FDHT) for Estrogen, Androgen, and Progesterone Receptors to Improve Management of Breast and Prostate Cancers by Functional Imaging

J. Katzenellenbogen, 2020, Cancers.

Characterization of the Biological Roles of the Estrogen Receptors, ERα and ERβ, in Estrogen Target Tissues in Vivo through the Use of an ERα-Selective Ligand

B. Katzenellenbogen, J. Katzenellenbogen, H. Harris, 2002 .

Imaging Diagnostic and Therapeutic Targets: Steroid Receptors in Breast Cancer

Farrokh Dehdashti, Hannah M Linden, Amy M Fowler, 2016, The Journal of Nuclear Medicine.

Positron emission tomography with 2-[18F]Fluoro-2-deoxy-D-glucose and 16alpha-[18F]fluoro-17beta-estradiol in breast cancer: correlation with estrogen receptor status and response to systemic therapy.

M. Welch, J. Katzenellenbogen, B. Siegel, 1996, Clinical cancer research : an official journal of the American Association for Cancer Research.

Estrogen dendrimer conjugates that preferentially activate extranuclear, nongenomic versus genomic pathways of estrogen action.

Cory C. Funk, B. Katzenellenbogen, R. Schiff, 2006, Molecular endocrinology.

Assessment of Progesterone Receptors in Breast Carcinoma by PET with 21-18F-Fluoro-16α,17α-[(R)-(1′-α-furylmethylidene)Dioxy]-19-Norpregn-4-Ene-3,20-Dione

R. Aft, C. Dence, M. Welch, 2012, The Journal of Nuclear Medicine.

PET-based estradiol challenge as a predictive biomarker of response to endocrine therapy in women with estrogen-receptor-positive breast cancer

Kathryn Trinkaus, Michael J. Welch, John A. Katzenellenbogen, 2009, Breast Cancer Research and Treatment.

Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer

B. Katzenellenbogen, J. Katzenellenbogen, 2000, Breast cancer research : BCR.

Mutation of the palmitoylation site of estrogen receptor α in vivo reveals tissue-specific roles for membrane versus nuclear actions

Sung Hoon Kim, Daniel Henrion, Pierre Chambon, 2013, Proceedings of the National Academy of Sciences.

Systems Structural Biology Analysis of Ligand Effects on ERα Predicts Cellular Response to Environmental Estrogens and Anti-hormone Therapies.

O. Elemento, J. Nwachukwu, S. Srinivasan, 2017, Cell chemical biology.

Positron Tomographic Assessment of 16α-[18F] Fluoro-17β-Estradiol Uptake in Metastatic Breast Carcinoma

M. Mintun, M. Welch, J. Katzenellenbogen, 1991 .

Breast cancer: PET imaging of estrogen receptors.

M. Mintun, M. Welch, J. Katzenellenbogen, 1988, Radiology.

Synthesis of an Estrogen Receptor β-Selective Radioligand: 5-[18F]Fluoro-(2R*,3S*)-2,3-bis(4-hydroxyphenyl)pentanenitrile and Comparison of in Vivo Distribution with 16α-[18F]Fluoro-17β-estradiol

Michael J. Welch, John A. Katzenellenbogen, C. Dence, 2005 .

Estrogen receptor binding tolerance of 16α-substituted estradiol derivatives

J. Katzenellenbogen, T. Fevig, M. K. Mao, 1988, Steroids.

Estrogens and androgens inhibit association of RANKL with the pre‐osteoblast membrane through post‐translational mechanisms

B. Katzenellenbogen, B. Frenkel, J. Katzenellenbogen, 2017, Journal of cellular physiology.

Non-nuclear-initiated actions of the estrogen receptor protect cortical bone mass.

B. Katzenellenbogen, P. Roberson, J. Katzenellenbogen, 2013, Molecular endocrinology.

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

B. Katzenellenbogen, B. L. Riggs, J. Katzenellenbogen, 2001, Journal of cellular biochemistry.

Analogs of methyl-piperidinopyrazole (MPP): antiestrogens with estrogen receptor alpha selective activity.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2009, Bioorganic & medicinal chemistry letters.

Defining the "S" in SERMs

B. Katzenellenbogen, J. Katzenellenbogen, 2002, Science.

Compatibility of organic solvents with the Salmonella/microsome test.

B. Ames, J. Katzenellenbogen, D. Maron, 1981, Mutation research.

Longitudinal Noninvasive Imaging of Progesterone Receptor as a Predictive Biomarker of Tumor Responsiveness to Estrogen Deprivation Therapy

John A. Katzenellenbogen, Farrokh Dehdashti, C. Dence, 2014, Clinical Cancer Research.

Improved Methods for the Synthesis of [?- 11 C]Palmitic Acid

M. Welch, E. Hostetler, J. Katzenellenbogen, 1998 .

Structure-activity study of 6-substituted 2-pyranones as inactivators of alpha-chymotrypsin.

J. Katzenellenbogen, W. Boulanger, 1986, Journal of medicinal chemistry.

Estrogen photoaffinity labels. 1. Chemical and radiochemical synthesis of hexestrol diazoketone and azide derivatives; photochemical studies in solution.

J. Katzenellenbogen, K. Carlson, H. J. Johnson, 1977, Biochemistry.

2-Arylindenes and 2-arylindenones: molecular structures and considerations in the binding orientation of unsymmetrical nonsteroidal ligands to the estrogen receptor.

J. Katzenellenbogen, S. R. Wilson, G. Anstead, 1989, Journal of medicinal chemistry.

Structure-Activity Study of 6-Substituted 2-Pyranones as Inactivators of α-Chymotrypsin.

J. Katzenellenbogen, W. Boulanger, 1986 .

New approaches to the synthesis of alkyl-substituted enol lactone systems, inhibitors of the serine protease elastase

J. Katzenellenbogen, W. Dai, 1993 .

Dual suppression of estrogenic and inflammatory activities for targeting of endometriosis

Robert N. Taylor, B. Katzenellenbogen, J. Nwachukwu, 2015, Science Translational Medicine.

Considerations in the design and evaluation of cytotoxic estrogens

B. Katzenellenbogen, J. Katzenellenbogen, 1982, Breast Cancer Research and Treatment.

Comparison of animal models for the evaluation of radiolabeled androgens.

J. Engelbach, M. Welch, J. Katzenellenbogen, 2001, Nuclear medicine and biology.

Effect of administration route on FES uptake into MCF-7 tumors.

M. Welch, J. Katzenellenbogen, L. Jones, 2001, Nuclear medicine and biology.

Bromo[18F]fluorination of cyclohexenes: a method for the preparation of [18F]fluorocyclohexanes

M. Welch, J. Katzenellenbogen, Y. Choe, 1995 .

Effects of Exposure to the Endocrine-Disrupting Chemical Bisphenol A During Critical Windows of Murine Pituitary Development

J. Katzenellenbogen, J. Flaws, Wei Wang, 2018, Endocrinology.

Protective Hematopoietic Effect of Estrogens in a Mouse Model of Thrombosis: Respective Roles of Nuclear Versus Membrane Estrogen Receptor α.

B. Katzenellenbogen, P. Chambon, J. Katzenellenbogen, 2015, Endocrinology.

Cyclin D1 integrates estrogen-mediated DNA damage repair signaling.

J. Katzenellenbogen, M. Lisanti, Ke Chen, 2014, Cancer research.

The roles of membrane estrogen receptor subtypes in modulating dopamine transporters in PC‐12 cells

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2008, Journal of neurochemistry.

Altered ligand binding properties and enhanced stability of a constitutively active estrogen receptor: evidence that an open pocket conformation is required for ligand interaction.

K E Carlson, B. Katzenellenbogen, J. Katzenellenbogen, 1997, Biochemistry.

Effective combination treatments for breast cancer inhibition by FOXM1 inhibitors with other targeted cancer drugs

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2023, Breast Cancer Research and Treatment.

Suppression of FOXM1 activities and breast cancer growth in vitro and in vivo by a new class of compounds

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2019, npj Breast Cancer.

Design , Synthesis , and Preclinical Characterization of the Selective Androgen Receptor Modulator ( SARM ) RAD 140

Gary Hattersley, John A. Katzenellenbogen, Chris P. Miller, 2010 .

Elemental isomerism: a boron-nitrogen surrogate for a carbon-carbon double bond increases the chemical diversity of estrogen receptor ligands.

F. Stossi, B. Katzenellenbogen, A. Joachimiak, 2007, Chemistry & biology.

Synthesis and biological evaluation of RGD peptides with the 99mTc/188Re chelated iminodiacetate core: highly enhanced uptake and excretion kinetics of theranostics against tumor angiogenesis

J. Katzenellenbogen, Ji Sun Kim, Sang Eun Kim, 2013 .

Activation of estrogen receptor β is a prerequisite for estrogen‐dependent upregulation of nitric oxide synthases in neonatal rat cardiac myocytes

B. Katzenellenbogen, R. Karas, J. Katzenellenbogen, 2001, FEBS letters.

Protein kinase A activation of estrogen receptor alpha transcription does not require proteasome activity and protects the receptor from ligand-mediated degradation.

B. Katzenellenbogen, J. Katzenellenbogen, M. Shupnik, 2004, Endocrinology.

Antiestrogen basicity--activity relationships: a comparison of the estrogen receptor binding and antiuterotrophic potencies of several analogues of (Z)-1,2-diphenyl-1-[4-[2-(dimethylamino)ethoxy]phenyl]-1-butene (tamoxifen, Nolvadex) having altered basicity.

B. Katzenellenbogen, J. Katzenellenbogen, D. Robertson, 1982, Journal of medicinal chemistry.

Allosteric Control of Ligand Selectivity between Estrogen Receptors α and β - Implications for Other Nuclear Receptors

John A. Katzenellenbogen, B. Katzenellenbogen, J. Katzenellenbogen, 2004 .

New Class of Selective Estrogen Receptor Degraders (SERDs): Expanding the Toolbox of PROTAC Degrons.

Jian Min, Abhishek Sharma, Sarat Chandarlapaty, 2018, ACS medicinal chemistry letters.

New approach for visualizing estrogen receptors in target cells using inherently fluorescent ligands and image intensification.

J. Katzenellenbogen, H. Magdelenat, P. Martin, 1983, Cancer research.

Tamoxifen and Raloxifene Differ in Their Functional Interactions with Aspartate 351 of Estrogen Receptor α

M. Lupien, J. Katzenellenbogen, S. Mader, 2006, Molecular Pharmacology.

Fluorine-Substituted Cyclofenil Derivatives as Estrogen Receptor Ligands: Synthesis and Structure-Affinity Relationship Study of Potential PET Agents for Imaging Estrogen Receptors in Breast Cancer

J. Katzenellenbogen, J. Seo, Dong Wook Kim, 2008 .

Fluorine-substituted cyclofenil derivatives as estrogen receptor ligands: synthesis and structure-affinity relationship study of potential positron emission tomography agents for imaging estrogen receptors in breast cancer.

Dong Wook Kim, J. Katzenellenbogen, K. Carlson, 2006, Journal of medicinal chemistry.

Site-specific fluorescent labeling of estrogen receptors and structure-activity relationships of ligands in terms of receptor dimer stability.

J. Katzenellenbogen, A. Tamrazi, 2003, Methods in enzymology.

Chapter 21 Inhibitors of Nuclear Hormone Receptor/Coactivator Interactions

J. Katzenellenbogen, T. Moore, 2009 .

Estrogen receptor alpha/co-activator interaction assay: TR-FRET.

J. Katzenellenbogen, J. R. Gunther, T. Moore, 2015, Methods in molecular biology.

Nonsteroidal bivalent estrogen ligands: an application of the bivalent concept to the estrogen receptor.

Marcus Weber, J. Katzenellenbogen, A. Bujotzek, 2013, ACS chemical biology.

Probing the topological tolerance of multimeric protein interactions: evaluation of an estrogen/synthetic ligand for FK506 binding protein conjugate.

J. Katzenellenbogen, J. R. Gunther, T. Moore, 2010, Bioconjugate chemistry.

ESTROGEN RECEPTOR-BASED IMAGING AGENTS. 1. SYNTHESIS AND RECEPTOR BINDING AFFINITY OF SOME AROMATIC AND D-RING HALOGENATED ESTROGENS

J. Katzenellenbogen, D. Heiman, S. G. Senderoff, 1981 .

Interactions of exogenous endocrine active substances with nuclear receptors

J. Katzenellenbogen, R. Muthyala, 2003 .

In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.

S. Gambhir, T. Massoud, J. Katzenellenbogen, 2011, Molecular endocrinology.

Neural-Network Scoring Functions Identify Structurally Novel Estrogen-Receptor Ligands

Rommie E. Amaro, Jacob D. Durrant, Tavina L. Offutt, 2015, J. Chem. Inf. Model..

Positron tomographic assessment of androgen receptors in prostatic carcinoma

C. Dence, M. Welch, J. Katzenellenbogen, 2005, European Journal of Nuclear Medicine and Molecular Imaging.

Assessment of 21-[18F]fluoro-16 alpha-ethyl-19-norprogesterone as a positron-emitting radiopharmaceutical for the detection of progestin receptors in human breast carcinomas.

M J Welch, F Dehdashti, M. Welch, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

The structural pervasiveness of estrogenic activity.

J. Katzenellenbogen, J A Katzenellenbogen, 1995, Environmental health perspectives.

Structure‐Function Relationships in Estrogen Receptors and the Characterization of Novel Selective Estrogen Receptor Modulators with Unique Pharmacological Profiles

B. Katzenellenbogen, J. Katzenellenbogen, Jun Sun, 2001, Annals of the New York Academy of Sciences.

Enzymatic Synthesis of Juvenile Hormone in Manduca sexta

J. Katzenellenbogen, J. H. Law, S. Bowlus, 1976 .

Pathway Preferential Estrogens Prevent Hepatosteatosis Due to Ovariectomy and High-Fat Diets

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2021, Nutrients.

Fluorine-18 labeled estrogens: Synthesis and biological evaluation of 11β and 17α substituted estradiols

M. Welch, M. Pomper, J. Katzenellenbogen, 1991 .

Synthesis of the (E) and (Z) isomers of the antiestrogen tamoxifen and its metabolite, hydroxytamoxifen, in tritium-labeled form

J. Katzenellenbogen, D. Robertson, D. W. Robertson, 1982 .

1,2‐BIS(4‐HYDROXYPHENYL)‐3,4‐DIHYDRO‐6‐HYDROXYNAPHTHALENE, A PHOTOFLUOROGENIC LIGAND FOR THE ESTROGEN RECEPTOR

J. Katzenellenbogen, R. D. Bindal, 1986, Photochemistry and Photobiology.

1,2-Diaryl-3,4-dihydronaphthalenes: photofluorogenic ligands for the estrogen receptor.

J. Katzenellenbogen, R. D. Bindal, 1985, Journal of steroid biochemistry.

Triarylethylene bisphenols with a novel cycle are ligands for the estrogen receptor.

J. Katzenellenbogen, S. H. Kim, 2000, Bioorganic & medicinal chemistry.

Comparative binding affinities of estrogen derivatives.

J. Katzenellenbogen, 1978, Cancer treatment reports.

Designing steroid receptor-based radiotracers to image breast and prostate tumors.

J. Katzenellenbogen, 1995, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

6α-[18F]Fluoroprogesterone: Synthesis via halofluorination-oxidation, receptor binding and tissue distribution

M. Welch, J. Katzenellenbogen, Y. Choe, 1995 .

Target tissue uptake selectivity of three fluorine-substituted progestins: potential imaging agents for receptor-positive breast tumors.

M. Welch, M. Pomper, J. Katzenellenbogen, 1990, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Estradiol promotes cell survival and induces Greb1 expression in granulosa cell tumors of the ovary through an ERα‐dependent mechanism

C. Genestie, J. Katzenellenbogen, I. Treilleux, 2021, The Journal of pathology.

Estrogen Receptor Beta 1: A Potential Therapeutic Target for Female Triple Negative Breast Cancer.

B. Katzenellenbogen, J. Katzenellenbogen, Sung Hoon Kim, 2022, Endocrinology.

[125I]Iododesethyl tamoxifen aziridine: Synthesis and covalent labeling of the estrogen receptor with an iodine-labeled affinity label

B. Katzenellenbogen, F. Salituro, J. Katzenellenbogen, 1986, Steroids.

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

B. Katzenellenbogen, J. Foidart, J. Katzenellenbogen, 2022 .

Facile synthesis of high affinity styrylpyridine systems as inherently fluorescent ligands for the estrogen receptor.

J. Katzenellenbogen, K. Carlson, M. Meyers, 1998, Bioorganic & medicinal chemistry letters.

Nuclear hormone receptors: ligand-activated regulators of transcription and diverse cell responses.

B. Katzenellenbogen, J. Katzenellenbogen, John A. Katzenelienbogen, 1996, Chemistry & biology.

A dual-acceptor time-resolved Föster resonance energy transfer assay for simultaneous determination of thyroid hormone regulation of corepressor and coactivator binding to the thyroid hormone receptor: Mimicking the cellular context of thyroid hormone action.

J. Katzenellenbogen, M. Jeyakumar, 2009, Analytical biochemistry.

Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.

J. Katzenellenbogen, J. Baxter, P. Webb, 2008, Biochemistry.

Diarylpropionitrile (DPN) enantiomers: synthesis and evaluation of estrogen receptor β-selective ligands.

J. Katzenellenbogen, K. Carlson, M. Jeyakumar, 2012, Journal of medicinal chemistry.

Synthesis and Evaluation of Estrogen Receptor β-Selective Ligands: Fluoroalkylated Indazole Estrogens

G. Cheon, J. Katzenellenbogen, D. Chi, 2008 .

Defining the Energetic Basis for a Conformational Switch Mediating Ligand-Independent Activation of Mutant Estrogen Receptors in Breast Cancer

B. Katzenellenbogen, S. Chandarlapaty, E. Tajkhorshid, 2021, Molecular Cancer Research.

Selective and potent agonists for estrogen receptor beta derived from molecular refinements of salicylaldoximes.

J. Katzenellenbogen, K. Carlson, T. Tuccinardi, 2011, European journal of medicinal chemistry.

Comparative QSAR Analysis of Estrogen Receptor Ligands

Rajni Garg, Corwin Hansch, John A. Katzenellenbogen, 1999 .

Directed Evolution of Human Estrogen Receptor Variants with Significantly Enhanced Androgen Specificity and Affinity*

B. Katzenellenbogen, Zhilei Chen, Huimin Zhao, 2004, Journal of Biological Chemistry.

Triarylpyrazoles with basic side chains: development of pyrazole-based estrogen receptor antagonists.

B. Katzenellenbogen, J. Katzenellenbogen, S. Stauffer, 2001, Bioorganic & medicinal chemistry.

ESR1 and ESR2 differentially regulate daily and circadian activity rhythms in female mice.

J. Katzenellenbogen, M. Mahoney, N. Yasui, 2014, Endocrinology.

Identification and structure-activity relationships of a novel series of estrogen receptor ligands based on 7-thiabicyclo[2.2.1]hept-2-ene-7-oxide.

J. Nwachukwu, Valerie Cavett, J. Katzenellenbogen, 2012, Journal of medicinal chemistry.

A new quinoline sensitizer-centered lanthanide chelate and its use for protein labling on Ni-NTA beads for TR LRET assays.

J. Katzenellenbogen, Sung Hoon Kim, Pinghua Ge, 2009, Chemical communications.

Predictive features of ligand‐specific signaling through the estrogen receptor

O. Elemento, J. Nwachukwu, S. Srinivasan, 2016, Molecular systems biology.

Synthesis and evaluation of estrogen receptor ligands with bridged oxabicyclic cores containing a diarylethylene motif: estrogen antagonists of unusual structure.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2005, Journal of medicinal chemistry.

Development of Selective Estrogen Receptor Modulator (SERM)‐Like Activity Through an Indirect Mechanism of Estrogen Receptor Antagonism: Defining the Binding Mode of 7‐Oxabicyclo[2.2.1]hept‐5‐ene Scaffold Core Ligands

J. Nwachukwu, S. Srinivasan, Valerie Cavett, 2012, ChemMedChem.

Phenethyl pyridines with non-polar internal substituents as selective ligands for estrogen receptor beta.

F. Stossi, B. Katzenellenbogen, J. Katzenellenbogen, 2009, European journal of medicinal chemistry.

Synthesis of anthranylaldoxime derivatives as estrogen receptor ligands and computational prediction of binding modes.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2006, Journal of medicinal chemistry.

Diaryl-substituted salicyl- and anthranyl-ketoximes as potential estrogen receptor ligands.

J. Katzenellenbogen, K. Carlson, S. Rapposelli, 2004, Farmaco.

Small-Animal PET of Steroid Hormone Receptors Predicts Tumor Response to Endocrine Therapy Using a Preclinical Model of Breast Cancer

C. Dence, T. Sharp, M. Welch, 2012, The Journal of Nuclear Medicine.

Estrogen Receptor-Selective Agonists Modulate Learning in Female Rats in a Dose- and Task-Specific Manner.

J. Katzenellenbogen, S. Schantz, D. Korol, 2016, Endocrinology.

Alternate substrate inhibitors of an alpha-chymotrypsin: enantioselective interaction of aryl-substituted enol lactones.

J. Katzenellenbogen, S. Daniels, P. Reed, 1990, Biochemistry.

Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyltechnetium-labeled octreotide.

M. Welch, J. Katzenellenbogen, C. Anderson, 1999, Nuclear medicine and biology.

Long-Term Follow Up and Treatment of a Female with Complete Estrogen Insensitivity.

J. Katzenellenbogen, K. Korach, Hyung-Goo Kim, 2020, The Journal of clinical endocrinology and metabolism.

Antagonists for Constitutively Active Mutant Estrogen Receptors: Insights into the Roles of Antiestrogen-Core and Side-Chain.

B. Katzenellenbogen, S. Chandarlapaty, J. Katzenellenbogen, 2018, ACS chemical biology.

Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis

J. Katzenellenbogen, S. Tiwari-Woodruff, Sung Hoon Kim, 2019, Scientific Reports.

Estrogen receptor-α and aryl hydrocarbon receptor involvement in the actions of botanical estrogens in target cells

B. Katzenellenbogen, J. Katzenellenbogen, J. Flaws, 2016, Molecular and Cellular Endocrinology.

Positron emission tomographic assessment of ”metabolic flare” to predict response of metastatic breast cancer to antiestrogen therapy

Michael J. Welch, John A. Katzenellenbogen, Barry A. Siegel, 1999, European Journal of Nuclear Medicine.

Chemical probes of estrogen action: affinity labeling.

J. Katzenellenbogen, K. Carlson, H. J. Johnson, 1976, Journal of toxicology and environmental health. Supplement.

Cyclopentadienyl Rhenium (Technetium) Tricarbonyl Complexes Integrated in Estrogen Receptor Ligands for ER+ Tumor Imaging

J. Katzenellenbogen, N. Ackroyd, 2006 .

Dual-mechanism estrogen receptor inhibitors expand the repertoire of anti-hormone therapy for breast cancer

B. Katzenellenbogen, J. Nwachukwu, S. Srinivasan, 2020, bioRxiv.

Suppression of breast cancer metastasis and extension of survival by a new antiestrogen in a preclinical model driven by mutant estrogen receptors

B. Katzenellenbogen, J. Katzenellenbogen, K. Nettles, 2020, Breast Cancer Research and Treatment.

Compounds that inhibit chymotrypsin and cell replication.

J. Katzenellenbogen, S. Wyrick, J A Katzenellenbogen, 1986, Biochemical pharmacology.

Multiple functional therapeutic effects of the estrogen receptor β agonist indazole-Cl in a mouse model of multiple sclerosis

J. Katzenellenbogen, S. Kumar, S. Moore, 2014, Proceedings of the National Academy of Sciences.

Three-dimensional model for the hormone binding domains of steroid receptors.

R A Goldstein, P. Wolynes, Z. Luthey-Schulten, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

B. Katzenellenbogen, E. Liu, J. Katzenellenbogen, 2013, Molecular systems biology.

Discovery of long-chain salicylketoxime derivatives as monoacylglycerol lipase (MAGL) inhibitors.

J. Katzenellenbogen, K. Carlson, Sung Hoon Kim, 2018, European journal of medicinal chemistry.

Estrogen receptor-alpha agonists promote angiogenesis in human myometrial microvascular endothelial cells.

J. Katzenellenbogen, M. Zaitseva, P. Rogers, 2004, Journal of the Society for Gynecologic Investigation.

Full Antagonism of the Estrogen Receptor without a Prototypical Ligand Side Chain

J. Frasor, B. Katzenellenbogen, J. Nwachukwu, 2016, Nature Chemical Biology.

ESR1 F404 mutations and acquired resistance to fulvestrant in the plasmaMATCH study.

J. Katzenellenbogen, N. Turner, A. Ring, 2022, Journal of Clinical Oncology.

Alleviation of extensive visual pathway dysfunction by a remyelinating drug in a chronic mouse model of multiple sclerosis

J. Katzenellenbogen, S. Tiwari-Woodruff, Sung Hoon Kim, 2020, Brain pathology.

Different Residues of the Human Estrogen Receptor Are Involved in the Recognition of Structurally Diverse Estrogens and Antiestrogens*

B. Katzenellenbogen, J. Katzenellenbogen, J A Katzenellenbogen, 1997, The Journal of Biological Chemistry.

Identification of Amino Acids in the Hormone Binding Domain of the Human Estrogen Receptor Important in Estrogen Binding*

B. Katzenellenbogen, J. Katzenellenbogen, K. Weis, 1996, The Journal of Biological Chemistry.

PLASMIN-ACTIVATED PRODRUGS FOR CANCER CHEMOTHERAPY. 2. SYNTHESIS AND BIOLOGICAL ACTIVITY OF PEPTIDYL DERIVATIVES OF DOXORUBICIN

J. Katzenellenbogen, P. Chakravarty, P. L. Carl, 1983 .

Synthesis and biological evaluation of a fluorine-18 labeled estrogen receptor-alpha selective ligand: [18F] propyl pyrazole triol.

M. Welch, J. Katzenellenbogen, M. Al-Qahtani, 2003, Nuclear medicine and biology.

Bromine- and iodine-substituted 16alpha,17alpha-dioxolane progestins for breast tumor imaging and radiotherapy: synthesis and receptor binding affinity.

M. Welch, J. Katzenellenbogen, K. Carlson, 2006, Journal of medicinal chemistry.

Highly stereoselective and completely regiospecific method for the dehydration of .beta.-hydroxy esters via .beta.-alanoxy enolates. Application to the synthesis of trisubstituted olefins and two ant mandibular gland secretions

J. Katzenellenbogen, T. Utawanit, 1974 .

Pharmacokinetics of the estrogen receptor subtype-selective ligands, PPT and DPN: quantification using UPLC-ES/MS/MS.

J. Katzenellenbogen, D. Korol, M. Churchwell, 2012, Journal of pharmaceutical and biomedical analysis.

A HIGHLY STEREOSELECTIVE AND COMPLETELY REGIOSPECIFIC METHOD FOR THE DEHYDRATION OF BETA-HYDROXY ESTERS VIA BETA-ALANOXY ENOLATES, APPLICATION TO THE SYNTHESIS OF TRISUBSTITUTED OLEFINS AND TWO ANT MANDIBULAR GLAND SECRETIONS

J. Katzenellenbogen, T. Utawanit, 1974 .

Haloenol lactones: enzyme-activated irreversible inactivators for serine proteases. Inactivation of alpha-chymotrypsin.

J. Katzenellenbogen, G. Krafft, P. Chakravarty, 1982, The Journal of biological chemistry.

Receptor-BindingRadiopharmaceuticalsfor ImagingBreast Tumors:Estrogen Receptor Interactionsand Selectivityof Tissue Uptakeof HalogenatedEstrogen Analogs

J. Katzenellenbogen, K. Carlson, D. Heiman, 1980 .

A new fluorescence complementation biosensor for detection of estrogenic compounds

Huimin Zhao, Huimin Zhao, J. Katzenellenbogen, 2011, Biotechnology and bioengineering.

Synthesis and tissue biodistribution of [omega-11C]palmitic acid. A novel PET imaging agent for cardiac fatty acid metabolism.

M J Welch, C. Dence, M. Welch, 1994, Journal of medicinal chemistry.

Molecular structures, conformational analysis, and preferential modes of binding of 3-aroyl-2-arylbenzo[b]thiophene estrogen receptor ligands: LY117018 and aryl azide photoaffinity labeling analogs.

J. Katzenellenbogen, S. R. Wilson, P. Kym, 1993, Journal of medicinal chemistry.

R. Altman, T. Stearns, J. Katzenellenbogen, 2019, Nature Communications.

SYNTHESIS OF THE NATURAL ISOMER OF A TETRAHOMOTERPENE ALCOHOL OBTAINED FROM THE CODLING MOTH

J. Katzenellenbogen, S. Bowlus, 1973 .

Conformational changes and coactivator recruitment by novel ligands for estrogen receptor-alpha and estrogen receptor-beta: correlations with biological character and distinct differences among SRC coactivator family members.

B. Katzenellenbogen, J. Katzenellenbogen, J. Sun, 2000, Endocrinology.

Carbon-11-labeled estrogens as potential imaging agents for breast tumors.

C. Dence, M. Welch, J. Katzenellenbogen, 1996, Nuclear medicine and biology.

11β‐Substituted Estradiol Derivatives. Part 2. Potential Carbon‐ 11‐ and Iodine‐Labeled Probes for the Estrogen Receptor.

J. Katzenellenbogen, K. Carlson, E. Napolitano, 1995 .

Targeting the oncogenic transcription factor FOXM1 to improve outcomes in all subtypes of breast cancer

B. Katzenellenbogen, J. Katzenellenbogen, V. S. Guillen, 2023, Breast Cancer Research.

Antiestrogens and antiestrogen metabolites: preparation of tritium-labeled (+/-)-cis-3-[p-(1,2,3,4-tetrahydro-6-methoxy-2-phenyl-1-naphthyl)phenoxyl]-1,2-propanediol (U-23469) and characterization and synthesis of a biologically important metabolite.

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 1979, Journal of medicinal chemistry.

A-CD estrogens. I. Substituent effects, hormone potency, and receptor subtype selectivity in a new family of flexible estrogenic compounds.

J. Katzenellenbogen, K. Carlson, R. Lau, 2011, Journal of medicinal chemistry.

Molecular basis for the subtype discrimination of the estrogen receptor-beta-selective ligand, diarylpropionitrile.

B. Katzenellenbogen, J. Katzenellenbogen, J. Baudry, 2003, Molecular endocrinology.

Furans with basic side chains: synthesis and biological evaluation of a novel series of antagonists with selectivity for the estrogen receptor alpha.

B. Katzenellenbogen, J. Katzenellenbogen, D. Mortensen, 2001, Bioorganic & medicinal chemistry letters.

In vivo comparison of 16 alpha[77Br]bromoestradiol-17 beta and 16 alpha-[125I]iodoestradiol-17 beta.

M. Welch, J. Katzenellenbogen, K. Carlson, 1982, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Positron tomographic assessment of 16 alpha-[18F] fluoro-17 beta-estradiol uptake in metastatic breast carcinoma.

M. Mintun, M. Welch, J. Katzenellenbogen, 1991, Journal of nuclear medicine : official publication, Society of Nuclear Medicine.

Progestin 16 alpha, 17 alpha-dioxolane ketals as molecular probes for the progesterone receptor: synthesis, binding affinity, and photochemical evaluation.

J. Katzenellenbogen, K. Carlson, P. Kym, 1993, Journal of medicinal chemistry.

Monitoring a coordinated exchange process in a four-component biological interaction system: development of a time-resolved terbium-based one-donor/three-acceptor multicolor FRET system.

J. Katzenellenbogen, Sung Hoon Kim, J. R. Gunther, 2010, Journal of the American Chemical Society.

64Cu Core-labeled nanoparticles with high specific activity via metal-free click chemistry.

Karen L Wooley, Michael J Welch, Dexing Zeng, 2012, ACS nano.

An efficient route for the preparation of a 21-fluoro progestin-16 alpha,17 alpha-dioxolane, a high-affinity ligand for PET imaging of the progesterone receptor.

J. Katzenellenbogen, Wang Mao, D. Vijaykumar, 2002, The Journal of organic chemistry.

New dithiocarbamato‐carboxylate chelation units for linking M(CO)3+ (M = Tc, Re) species to other molecules

J. Katzenellenbogen, L. Luyt, A. Lumpov, 2001 .

Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats

J. Katzenellenbogen, S. Schantz, D. Korol, 2010, Hormones and Behavior.

Strategies for the labeling of halogen-substituted peroxisome proliferator-activated receptor gamma ligands: potential positron emission tomography and single photon emission computed tomography imaging agents.

R. Mach, J. Katzenellenbogen, Kyo-Chul Lee, 2007, Bioconjugate chemistry.

Steroids Labeled with 18F for Imaging Tumors by Positron Emission Tomography

J. Katzenellenbogen, 2001 .

Fluorescence properties of 2,3-diarylindenes

J. Katzenellenbogen, G. Anstead, 1988 .

Designing effective hybrid toxins.

J. Katzenellenbogen, 2005, Chemistry & biology.

Design, synthesis, and in vitro biological evaluation of small molecule inhibitors of estrogen receptor alpha coactivator binding.

J. Katzenellenbogen, A. Tamrazi, Margaret L. Collins, 2004, Journal of medicinal chemistry.

Biodistribution of N-alkyl and N-fluoroalkyl derivatives of spiroperidol; radiopharmaceuticals for PET studies of dopamine receptors.

M. Welch, J. Katzenellenbogen, M. Kilbourn, 1986, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

A simple method to generate [18F]triflyl fluoride for 18F radiosynthesis

J. Katzenellenbogen, Dong Zhou, 2021, Tetrahedron Letters.

An X-ray crystallographic study of the nonsteroidal contraceptive agent centchroman.

J. Katzenellenbogen, J. O’Neil, S. R. Wilson, 1994, Journal of medicinal chemistry.

Synthesis, radiolabeling and tissue distribution of 11 beta-fluoroalkyl- and 11 beta-fluoroalkoxy-substituted estrogens: target tissue uptake selectivity and defluorination of a homologous series of fluorine-18-labeled estrogens.

M. Welch, J. Katzenellenbogen, H. VanBrocklin, 1993, Nuclear medicine and biology.

Design and synthesis of functionalized cyclopentadienyl tricarbonylmetal complexes for technetium-94m PET imaging of estrogen receptors.

Michael J Welch, Ephraim E. Parent, M. Welch, 2005, Bioconjugate chemistry.

Protein and peptide labeling with (cyclopentadienyl)tricarbonyl rhenium and technetium.

J. Katzenellenbogen, T. W. Spradau, 1998, Bioconjugate chemistry.

Salicylketoximes That Target Glucose Transporter 1 Restrict Energy Supply to Lung Cancer Cells

J. Katzenellenbogen, K. Carlson, Xiaozhuo Chen, 2015, ChemMedChem.

Commentary: The Structural Pervasiveness of Estrogenic Activity

J. Katzenellenbogen, 1995 .

Improved chemical syntheses of 5,6-dihydro-5-fluorouracil.

J. Katzenellenbogen, Andrew L. LaFrate, 2007, Journal of Organic Chemistry.

Preparation of Hexahydrobenzo[f]isoquinolines Using a Vinylogous Pictet—Spengler Cyclization.

J. Katzenellenbogen, R. Cesati, 2001 .

Estrogen regulation of human osteoblast function is determined by the stage of differentiation and the estrogen receptor isoform

B. Katzenellenbogen, J. Katzenellenbogen, S. Khosla, 2022 .

Exploration of alcohol-enhanced Cu-mediated radiofluorination towards practical labeling.

J. Katzenellenbogen, W. Chu, Dong Zhou, 2018, Journal of labelled compounds & radiopharmaceuticals.

[18F]Tosyl fluoride as a versatile [18F]fluoride source for the preparation of 18F-labeled radiopharmaceuticals

J. Katzenellenbogen, Jinbin Xu, W. Chu, 2023, Scientific Reports.

Solid phase radiosynthesis of an olaparib derivative using 4-[18F] fluorobenzoic acid and in vivo evaluation in breast and prostate cancer xenograft models for PARP-1 expression.

J. Katzenellenbogen, Jinbin Xu, B. Rogers, 2022, Nuclear Medicine and Biology.

Facile purification and click labeling with 2-[18F]fluoroethyl azide using solid phase extraction cartridges.

R. Mach, J. Katzenellenbogen, J. McConathy, 2015, Tetrahedron letters.

Determination of molar activity of [18F]fluoride by HPLC via sulfonyl derivatization.

J. Katzenellenbogen, Dong Zhou, S. Schwarz, 2021, Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine.

Evaluation of aromatic radiobromination by nucleophilic substitution using diaryliodonium salt precursors.

J. Katzenellenbogen, Sung Hoon Kim, Thomas F Voller, 2017, Journal of labelled compounds & radiopharmaceuticals.

Endothelial ERα promotes glucose tolerance by enhancing endothelial insulin transport to skeletal muscle

B. Katzenellenbogen, J. Katzenellenbogen, C. Mineo, 2023, Nature communications.

The nature of the ligand-binding pocket of estrogen receptor alpha and beta: The search for subtype-selective ligands and implications for the prediction of estrogenic activity

B. Katzenellenbogen, J. Katzenellenbogen, R. Muthyala, 2003 .

(2R*,3S*)-1-(125I)IODO-2,3-BIS(4-HYDROXYPHENYL)PENTANE ((125I)IODONORHEXESTROL), AND (2R*,3S*)-1-(77BR)BROMO-2,3-BIS(4-HYDROXYPHENYL)PENTANE ((77BR)BROMONORHEXESTROL), TWO Γ-EMITTING ESTROGENS THAT SHOW RECEPTOR-MEDIATED UPTAKE BY TAR

M. Welch, J. Katzenellenbogen, S. Landvatter, 1983 .

Direct G Protein Modulation of Cav2 Calcium Channels

B. Spiegelman, S. Kliewer, G. Eichele, 2006, Pharmacological Reviews.

N-(3-[18F]fluoropropyl)-spiperone: the preferred 18F labeled spiperone analog for positron emission tomographic studies of the dopamine receptor.

M. Raichle, C. Dence, M. Welch, 1988, International journal of radiation applications and instrumentation. Part B, Nuclear medicine and biology.

Experimental versus predicted affinities for ligand binding to estrogen receptor: iterative selection and rescoring of docked poses systematically improves the correlation

James M. Anderson, Hooman Shadnia, James S. Wright, 2013, Journal of Computer-Aided Molecular Design.

A short, stereoselective route to 16.alpha.-(substituted-alkyl)estradiol derivatives

J. Katzenellenbogen, T. Fevig, 1987 .

A Short, Stereoselective Route to 16α-(Substituted-Alkyl)estradiol Derivatives.

J. Katzenellenbogen, T. Fevig, 1987 .

Reduction of stimulated sodium iodide symporter expression by estrogen receptor ligands in breast cancer cells.

J. Katzenellenbogen, Hwan-Jeong Jeong, M. Sohn, 2011, Nuclear medicine and biology.

The Activation Function-1 of Estrogen Receptor Alpha Prevents Arterial Neointima Development Through a Direct Effect on Smooth Muscle Cells

B. Katzenellenbogen, J. Foidart, J. Katzenellenbogen, 2015, Circulation research.

Torsionally and hydrophobically modified 2,3-diarylindenes as estrogen receptor ligands.

J. Katzenellenbogen, S. R. Wilson, G. Anstead, 1990, Journal of Medicinal Chemistry.

A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes

J. Katzenellenbogen, F. Minutolo, 1998 .

Torsionally and Hydrophobically Modified 2,3‐Diarylindenes as Estrogen Receptor Ligands.

J. Katzenellenbogen, G. Anstead, K. Pinney, 1991 .

A Convenient Three-Component Synthesis of Substituted Cyclopentadienyl Tricarbonyl Rhenium Complexes.

J. Katzenellenbogen, F. Minutolo, 1998 .

Estrogen receptor transcription and transactivation Estrogen receptor alpha and estrogen receptor beta: regulation by selective estrogen receptor modulators and importance in breast cancer

B. Katzenellenbogen, J. Katzenellenbogen, 2000, Breast Cancer Research.

Corrigendum: Full antagonism of the estrogen receptor without a prototypical ligand side chain.

J. Frasor, B. Katzenellenbogen, J. Nwachukwu, 2017, Nature chemical biology.

Novel ligands that function as selective estrogens or antiestrogens for estrogen receptor-alpha or estrogen receptor-beta.

B. Katzenellenbogen, J. Katzenellenbogen, B. Fink, 1999 .

Halogen-substituted triarylpyrazoles: Potential estrogen receptor-alpha selective radiopharmaceuticals

J. Katzenellenbogen, D. Vijaykumar, 2001 .

Halo enol lactones: studies on the mechanism of inactivation of alpha-chymotrypsin.

J. Katzenellenbogen, S. Daniels, 1986, Biochemistry.

Integrative genomics of gene and metabolic regulation by estrogen receptors α and β, and their coregulators

B. Katzenellenbogen, E. Liu, J. Katzenellenbogen, 2013, Molecular systems biology.

Endogenous DOPA inhibits melanoma through suppression of CHRM1 signaling

B. Katzenellenbogen, J. Katzenellenbogen, Micha Feigin-Almon, 2022, Science advances.

Novel Ligands that Function as Selective Estrogens or Antiestrogens for Estrogen Receptor-α or Estrogen Receptor-β.

B. Katzenellenbogen, J. Katzenellenbogen, B. Fink, 1999, Endocrinology.

International Union of Pharmacology. LXIV. Estrogen Receptors

S. Fuqua, K. Dahlman-Wright, J. Gustafsson, 2006, Pharmacological Reviews.

Impact of estrogen receptor alpha and beta agonists on delayed alternation in middle-aged rats

J. Katzenellenbogen, S. Schantz, D. Korol, 2010, Hormones and Behavior.

Synthesis of 7alpha-(fluoromethyl)dihydrotestosterone and 7alpha-(fluoromethyl)nortestosterone, structurally paired androgens designed to probe the role of sex hormone binding globulin in imaging androgen receptors in prostate tumors by positron emission tomography.

Ephraim E. Parent, J. Katzenellenbogen, K. Carlson, 2007, The Journal of organic chemistry.

ESTROGEN RECEPTOR BASED IMAGING AGENTS. 2. SYNTHESIS AND RECEPTOR BINDING AFFINITY OF SIDE-CHAIN HALOGENATED HEXESTROL DERIVATIVES

J. Katzenellenbogen, D. Heiman, R. Goswamy, 1981 .

Evidence that phospholipase A2 activity is required for Golgi complex and trans Golgi network membrane tubulation.

J. Katzenellenbogen, P. de Figueiredo, W. Brown, 1998, Proceedings of the National Academy of Sciences of the United States of America.

Licorice root components in dietary supplements are selective estrogen receptor modulators with a spectrum of estrogenic and anti-estrogenic activities

B. Katzenellenbogen, J. Katzenellenbogen, K. Carlson, 2016, Steroids.

Synthesis of biphenyl proteomimetics as estrogen receptor-alpha coactivator binding inhibitors.

J. Katzenellenbogen, R. Hanson, P. T. Weiser, 2009, Organic letters.

Estrogen Receptors alpha and beta as determinants of gene expression: influence of ligand, dose, and chromatin binding.

B. Katzenellenbogen, J. Katzenellenbogen, T. Charn, 2008, Molecular endocrinology.

Monitoring a coordinated exchange process in a four-component biological interaction system: development of a time-resolved terbium-based one-donor/three-acceptor multicolor FRET system.

J. Katzenellenbogen, Sung Hoon Kim, J. R. Gunther, 2010, Journal of the American Chemical Society.

Proline-valine pseudo peptide enol lactones. Effective and selective inhibitors of chymotrypsin and human leukocyte elastase.

J. Katzenellenbogen, P E Reed, 1991, The Journal of biological chemistry.

A human estrogen receptor (ER)alpha mutation with differential responsiveness to nonsteroidal ligands: novel approaches for studying mechanism of ER action.

B. Katzenellenbogen, S. Gambhir, J. Katzenellenbogen, 2008, Molecular endocrinology.

In vitro and in vivo molecular imaging of estrogen receptor α and β homo- and heterodimerization: exploration of new modes of receptor regulation.

S. Gambhir, T. Massoud, J. Katzenellenbogen, 2011, Molecular endocrinology.

A molecular dynamics study of the stability of chymotrypsin acyl enzymes

John A. Katzenellenbogen, Guy W. Bemis, G. Bemis, 1992 .

Antagonists Selective for Estrogen Receptor α.

B. Katzenellenbogen, J. Katzenellenbogen, Shubin Sheng, 2002, Endocrinology.

Preparation of tritium-labeled 4-hydroxy-α-[p-(2-(N-pyrrolidinyl) ethoxy) phenyl]-α′-nitrostilbene (CN-928), a biologically-important metabolite of the antiestrogen CI-628

J. Katzenellenbogen, T. Tatee, D. W. Robertson, 1981 .

Anti-estrogen Interaction with Uterine Estrogen Receptors

B. Katzenellenbogen, J. Katzenellenbogen, E. Ferguson, 1979 .

Coordinated activation of c-Src and FOXM1 drives tumor cell proliferation and breast cancer progression

B. Katzenellenbogen, J. Katzenellenbogen, W. Muller, 2023, The Journal of clinical investigation.

Somatic estrogen receptor α mutations that induce dimerization promote receptor activity and breast cancer proliferation

B. Katzenellenbogen, S. Chandarlapaty, J. Reis-Filho, 2023, The Journal of clinical investigation.

Analogues of ERβ ligand chloroindazole exert immunomodulatory and remyelinating effects in a mouse model of multiple sclerosis

J. Katzenellenbogen, S. Tiwari-Woodruff, Kelley C. Atkinson, 2019, Scientific Reports.

Quantification of ligand-regulated nuclear receptor corepressor and coactivator binding, key interactions determining ligand potency and efficacy for the thyroid hormone receptor.

J. Katzenellenbogen, J. Baxter, P. Webb, 2008, Biochemistry.