C. Koboldt

发表

Kinetic basis for selective inhibition of cyclo-oxygenases.

J. Gierse, C. Koboldt, M. C. Walker, 1999, The Biochemical journal.

1,2‐Diarylpyrroles as Potent and Selective Inhibitors of Cyclooxygenase‐2.

C. Koboldt, K. Seibert, P. Isakson, 1997 .

1,2-Diarylimidazoles as potent, cyclooxygenase-2 selective, and orally active antiinflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 1997, Journal of medicinal chemistry.

Synthesis and biological evaluation of the 1,5-diarylpyrazole class of cyclooxygenase-2 inhibitors: identification of 4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyrazol-1-yl]benze nesulfonamide (SC-58635, celecoxib).

R. S. Rogers, C. Koboldt, K. Seibert, 1997, Journal of medicinal chemistry.

1,2‐Diarylcyclopentenes as Selective Cyclooxygenase‐2 Inhibitors and Orally Active anti‐Inflammatory Agents.

C. Koboldt, K. Seibert, P. Isakson, 1996 .

Expression and selective inhibition of the constitutive and inducible forms of human cyclo-oxygenase.

J. Gierse, C. Koboldt, K. Seibert, 1995, The Biochemical journal.

Selective cyclooxygenase-2 inhibitors: heteroaryl modified 1,2-diarylimidazoles are potent, orally active antiinflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 2000, Journal of medicinal chemistry.

Novel terphenyls as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.

C. Koboldt, K. Seibert, P. Isakson, 1996, Journal of medicinal chemistry.

Characterization of the Recombinant IKK1/IKK2 Heterodimer

C. Koboldt, S. Hauser, T. Hall, 2000, The Journal of Biological Chemistry.

3,4-diarylthiophenes are selective COX-2 inhibitors

R. S. Rogers, C. Koboldt, A. W. Veenhuizen, 1995 .

4,5‐Diaryloxazole inhibitors of cyclooxygenase‐2 (COX‐2)

C. Koboldt, K. Seibert, J. Masferrer, 1999, Medicinal research reviews.

Thiol and hydroxamic acid containing inhibitors of endothelin converting enzyme

C. Koboldt, J. Talley, W. M. Moore, 1993 .

Conformationally restricted 1,5-diarylpyrazoles are selective COX-2 inhibitors

C. Koboldt, J. Talley, S. Bertenshaw, 1996 .

Expression and selective inhibition of constitutive and inducible forms of cyclooxygenase.

J. Gierse, C. Koboldt, K. Seibert, 1995, Advances in prostaglandin, thromboxane, and leukotriene research.

Inhibitory effects of caffeic acid phenethyl ester on the activity and expression of cyclooxygenase-2 in human oral epithelial cells and in a rat model of inflammation.

C. Koboldt, J. Masferrer, K. Subbaramaiah, 1999, Cancer research.

N-[[(5-methyl-3-phenylisoxazol-4-yl)-phenyl]sulfonyl]propanamide, sodium salt, parecoxib sodium: A potent and selective inhibitor of COX-2 for parenteral administration.

C. Koboldt, K. Seibert, Y. Zhang, 2000, Journal of medicinal chemistry.

4-[5-Methyl-3-phenylisoxazol-4-yl]- benzenesulfonamide, valdecoxib: a potent and selective inhibitor of COX-2.

R. S. Rogers, C. Koboldt, K. Seibert, 2000, Journal of medicinal chemistry.

Synthesis and activity of sulfonamide-substituted 4,5-diaryl thiazoles as selective cyclooxygenase-2 inhibitors.

C. Koboldt, K. Seibert, P. Collins, 1999, Bioorganic & medicinal chemistry letters.

1,2-Diarylpyrroles as potent and selective inhibitors of cyclooxygenase-2.

C. Koboldt, K. Seibert, P. Isakson, 1997, Journal of medicinal chemistry.

1,2‐Diarylimidazoles as Potent, Cyclooxygenase‐2 Selective, and Orally Active Antiinflammatory Agents.

C. Koboldt, K. Seibert, P. Isakson, 2010 .

Diaryl indenes and benzofurans: Novel classes of potent and selective cyclooxygenase-2 inhibitors

C. Koboldt, P. Isakson, D. Reitz, 1995 .

Design and synthesis of sulfonyl-substituted 4,5-diarylthiazoles as selective cyclooxygenase-2 inhibitors.

C. Koboldt, K. Seibert, Y. Zhang, 1999, Bioorganic & medicinal chemistry letters.

1,2-Diarylcyclopentenes as selective cyclooxygenase-2 inhibitors and orally active anti-inflammatory agents.

C. Koboldt, P. Isakson, S. Gregory, 1995, Journal of medicinal chemistry.

Synthesis and Activity of Sulfonamide‐Substituted 4,5‐Diaryl Thiazoles as Selective Cyclooxygenase‐2 Inhibitors.

C. Koboldt, K. Seibert, P. Collins, 2010 .

Pharmacological analysis of cyclooxygenase-1 in inflammation.

C. Koboldt, K. Seibert, P. Isakson, 1998, Proceedings of the National Academy of Sciences of the United States of America.

A Single Amino Acid Difference between Cyclooxygenase-1 (COX-1) and −2 (COX-2) Reverses the Selectivity of COX-2 Specific Inhibitors*

J. Gierse, C. Koboldt, K. Seibert, 1996, The Journal of Biological Chemistry.

3,4-diarylpyrazoles: Potent and selective inhibitors of cyclooxygenase-2

C. Koboldt, K. Seibert, P. Isakson, 1997 .

Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity

J. Gierse, C. Koboldt, K. Seibert, 2005, Journal of Pharmacology and Experimental Therapeutics.

Diarylspiro[2.4]heptenes as orally active, highly selective cyclooxygenase-2 inhibitors: synthesis and structure-activity relationships.

C. Koboldt, K. Seibert, P. Isakson, 1996, Journal of medicinal chemistry.

Specific COX-2 inhibitors: from bench to bedside

C. Koboldt, K. Seibert, P. Isakson, 1998 .

Mechanism of inhibition of novel COX-2 inhibitors.

R. Kurumbail, L. Marnett, J. Gierse, 2002, Advances in experimental medicine and biology.

A structural feature of N-[2-(cyclohexyloxy)-4-nitrophenyl] methanesulfonamide (NS-398) that governs its selectivity and affinity for cyclooxygenase 2 (COX2)

C. Koboldt, K. Seibert, P. Isakson, 1995, Inflammation Research.

Epithelial Cells and in a Rat Model of Inflammation Activity and Expression of Cyclooxygenase-2 in Human Oral Inhibitory Effects of Caffeic Acid Phenethyl Ester on the Updated Version

C. Koboldt, J. Masferrer, K. Subbaramaiah, 1999 .

Selective cyclooxygenase inhibitors: novel 1,2-diarylcyclopentenes are potent and orally active COX-2 inhibitors.

C. Koboldt, K. Seibert, W. Perkins, 1994, Journal of medicinal chemistry.

Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.

J. Gierse, C. Koboldt, K. Seibert, 2005, Journal of Pharmacology and Experimental Therapeutics.

A three-step kinetic mechanism for selective inhibition of cyclo-oxygenase-2 by diarylheterocyclic inhibitors.

R. Kurumbail, J. Gierse, C. Koboldt, 2001, The Biochemical journal.

3,4-Diarylthiophenes Are Selective COX-2 Inhibitors.

C. Koboldt, A. W. Veenhuizen, W. Perkins, 1996 .

Valdecoxib: assessment of cyclooxygenase-2 potency and selectivity.

J. Gierse, C. Koboldt, K. Seibert, 2005, The Journal of pharmacology and experimental therapeutics.

Valdecoxib: Assessment of Cyclooxygenase-2 Potency and Selectivity

J. Gierse, C. Koboldt, K. Seibert, 2005, Journal of Pharmacology and Experimental Therapeutics.

SELECTIVE CYCLOOXYGENASE INHIBITORS : NOVEL 4-SPIRO 1,2-DIARYLCYCLOPENTENES ARE POTENT AND ORALLY ACTIVE COX-2 INHIBITORS

C. Koboldt, K. Seibert, P. Isakson, 1995 .