P. Groundwater

发表

The Differential Effects of Resveratrol and trans-ε-Viniferin on the GABA-Induced Current in GABAA Receptor Subtypes Expressed in Xenopus Laevis Oocytes.

P. Groundwater, K. Hamid, I. Ng, 2015, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Versatile routes to marine sponge metabolites through benzylidene rhodanines.

P. Groundwater, S. Bhakta, M. Gray, 2012, Organic letters.

Tetracyclic triterpenoids in herbal medicines and their activities in diabetes and its complications.

P. Groundwater, K. Hamid, C. Li, 2015, Current topics in medicinal chemistry.

Rifamycin Antibacterial Agents

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Identification of agents targeting FtsZ assembly.

P. Groundwater, D. Hibbs, D. Panda, 2016, Future medicinal chemistry.

3.2. Trimethoprim

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

4.1. Aminoglycoside Antibiotics

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Rational drug design — identifying and characterising a target

Rosaleen J. Anderson, P. Groundwater, Adam Todd, 2009 .

5.3. Cycloserine

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Design and synthesis of EGFR dimerization inhibitors and evaluation of their potential in the treatment of psoriasis.

Rosaleen J. Anderson, P. Groundwater, D. Hibbs, 2012, Bioorganic & medicinal chemistry.

Indolyl-3-acryloylglycine (IAG) is a putative diagnostic urinary marker for autism spectrum disorders.

P. Whiteley, P. Groundwater, P. Shattock, 2003, Medical science monitor : international medical journal of experimental and clinical research.

Experimental and theoretical charge density studies of 8-hydroxyquinoline cocrystallized with salicylic acid.

J. Platts, P. Groundwater, D. Hibbs, 2012, The journal of physical chemistry. A.

β-Alanyl aminopeptidase-activated fluorogenic probes for the rapid identification of Pseudomonas aeruginosa in clinical samples

P. Groundwater, D. Hibbs, J. Perry, 2016 .

The generation and reactivity of N-substituted, stabilised α,β:γ,δ-unsaturated azomethine ylides

Rosaleen J. Anderson, P. Groundwater, I. Fejes, 2002 .

An investigation of the effects of dithranol‐induced apoptosis in a human keratinocyte cell line

Rosaleen J. Anderson, P. Groundwater, S. E. George, 2013, The Journal of pharmacy and pharmacology.

The discovery of novel isoflavone pan peroxisome proliferator-activated receptor agonists.

P. Groundwater, D. Hibbs, M. Doddareddy, 2013, Bioorganic & medicinal chemistry.

Synthesis and biological evaluation of a series of flavones designed as inhibitors of protein tyrosine kinases.

P. Groundwater, J. Hickman, I. Dale, 1992, Anti-cancer drug design.

Stereo-specific cytotoxic effects of gossypol enantiomers and gossypolone in tumour cell lines.

P. Groundwater, J. Morgan, M. Shelley, 1999, Cancer letters.

Experimental and theoretical charge density distribution in Pigment Yellow 101.

J. Platts, P. Groundwater, D. Hibbs, 2015, Physical chemistry chemical physics : PCCP.

Answer to problems

Rosaleen J. Anderson, David J. Bendell, Paul William Groundwater, 2004 .

An experimental and theoretical charge density study of theophylline and malonic acid cocrystallization

P. A. Williams, J. Platts, P. Groundwater, 2022, RSC advances.

Understanding Hygroscopicity of Theophylline via a Novel Cocrystal Polymorph: A Charge Density Study.

J. Platts, P. Groundwater, D. Hibbs, 2021, The journal of physical chemistry. A.

Bicyclic 6-6 Systems: Four Heteroatoms 1:3

P. Groundwater, M. Nyerges, Roz J. Anderson, 2008 .

Alteration of serum and urinary lipolytic activity with weight loss in cachectic cancer patients.

I. Ferrier, P. Groundwater, M. Tisdale, 1990, British Journal of Cancer.

Tubulin-Binding 3,5-Bis(styryl)pyrazoles as Lead Compounds for the Treatment of Castration-Resistant Prostate Cancer

P. Groundwater, D. Hibbs, A. Kumari, 2020, Molecular Pharmacology.

Phytotherapies as New Drug Sources

P. Groundwater, D. Hibbs, R. Narlawar, 2015 .

Synthesis and biological evaluation of purpurealidin E-derived marine sponge metabolites: aplysamine-2, aplyzanzine A, and suberedamines A and B.

P. Groundwater, S. Bhakta, M. Gray, 2012, Journal of natural products.

The synthesis of pyranoacridinone inhibitors of protein tyrosine kinases

P. Groundwater, K. Solomons, 1994 .

The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications.

P. Groundwater, K. Hamid, K. Chan, 2013, Current medicinal chemistry.

A Simple RP-HPLC Method for the Determination of the Anti-Psoriatic Drug Dithranol and its Application in an In Vitro Cell Uptake Study

Rosaleen J. Anderson, P. Groundwater, S. George, 2012 .

Evaluation of a range of anti-proliferative assays for the preclinical screening of anti-psoriatic drugs: a comparison of colorimetric and fluorimetric assays with the thymidine incorporation assay.

Rosaleen J. Anderson, P. Groundwater, A. Cunningham, 2010, Assay and drug development technologies.

Exploring the excited-state charge transfer fluorescence profile of 7-hydroxycoumarin and 2-methylimidazole - a combined X-ray diffraction and theoretical approach.

J. Platts, P. Groundwater, D. Hibbs, 2022, Physical chemistry chemical physics : PCCP.

Synthesis of gossypol atropisomers and derivatives and evaluation of their anti-proliferative and anti-oxidant activity.

Rosaleen J. Anderson, W. J. Lough, P. Groundwater, 2005, Bioorganic & medicinal chemistry.

A new, one-step synthesis of 1-heteroaryl-2-alkylaminoethanols

Rosaleen J. Anderson, P. Groundwater, D. Hibbs, 2010 .

Discovery of 2′,6-Bis(4-hydroxybenzyl)-2-acetylcyclohexanone, a Novel FtsZ Inhibitor

P. Groundwater, D. Hibbs, M. Doddareddy, 2022, Molecules.

A Guide to In Silico Drug Design

P. Groundwater, D. Hibbs, Bryson A. Hawkins, 2022, Pharmaceutics.

Heterocycle-Fused Acridines

P. Groundwater, M. Munawar, 1997, Advances in Heterocyclic Chemistry.

Synthesis of indazole-N-oxides via the 1,7-electrocyclisation of azomethine ylides

P. Groundwater, M. Nyerges, L. Tőke, 2001 .

1.1. Microorganisms

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Current research and development into new antibacterial agents.

P. Groundwater, A. Todd, A. Worsley, 2009 .

Iminoacyl Halides and Oxy Functions

P. Groundwater, M. Nyerges, Roz J. Anderson, 2005 .

Synthesis and antimicrobial activity of quinoline-based 2-pyrazolines

P. Groundwater, M. Athar, M. Munawar, 2008 .

1,7-Electrocyclizations of Azomethine Ylides : Scope and Synthetic Aspects

P. Groundwater, J. Tóth, M. Nyerges, 2008 .

Synthesis of pyrido[2,3-c]acridines

P. Groundwater, M. Munawar, 1997 .

A novel synthesis of didehydroamino acid esters from azomethine ylides

P. Groundwater, D. Hibbs, M. Hursthouse, 1998 .

Silver Acetate Catalysed Asymmetric 1,3-Dipolar Cycloadditions of Imines and Chiral Acrylamides

P. Groundwater, D. Hibbs, S. Coles, 2003 .

Synthesis of Indazole-N-oxides via the 1,7-Electrocyclization of Azomethine Ylides.

P. Groundwater, M. Nyerges, A. Virányi, 2005 .

Synthesis of indazole-N-oxides via the 1,7-electrocyclization of azomethine ylides

P. Groundwater, M. Nyerges, L. Tőke, 2004 .

A comparison of the experimental and theoretical charge density distributions in two polymorphic modifications of piroxicam.

Peter A. Williams, J. Platts, P. Groundwater, 2016, Physical chemistry chemical physics : PCCP.

1,7-Electrocyclizations of α,β;γ,δ-Unsaturated 1,3-Dipoles

P. Groundwater, M. Nyerges, 1999 .

Electrocyclic aromatic substitution by nitrile ylides to give 3H-2-benzazepines: substituent effects and mechanism

P. Groundwater, J. Sharp, 1992 .

Synthesis and evaluation of fluorogenic 2-amino-1,8-naphthyridine derivatives for the detection of bacteria.

Rosaleen J. Anderson, P. Groundwater, M. Gray, 2012, Organic & biomolecular chemistry.

Organic Spectroscopic Analysis

Rosaleen J. Anderson, David J. Bendell, P. Groundwater, 2004 .

An Investigation of the Differential Effects of Ursane Triterpenoids from Centella asiatica, and Their Semisynthetic Analogues, on GABAA Receptors

P. Groundwater, K. Hamid, I. Ng, 2016, Chemical biology & drug design.

Sulfonamide Antibacterial Agents

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

cyp51A Mutations, Extrolite Profiles, and Antifungal Susceptibility in Clinical and Environmental Isolates of the Aspergillus viridinutans Species Complex

J. Frisvad, P. Groundwater, D. Hibbs, 2019, Antimicrobial Agents and Chemotherapy.

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Synthesis and evaluation of halogenated nitrophenoxazinones as nitroreductase substrates for the detection of pathogenic bacteria

Rosaleen J. Anderson, P. Groundwater, M. Gray, 2013 .

4.3. Tetracycline Antibiotics

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Nitroimidazole Antibacterial Agents

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Evaluation of fluorogenic aminonaphthalenesulfonamides and 6-hydrazinobenz[de]isoquinoline-1,3-diones for the detection of bacteria

P. Groundwater, D. Hibbs, J. Perry, 2016 .

A latent green fluorescent styrylcoumarin probe for the selective growth and detection of Gram negative bacteria.

P. Groundwater, D. Hibbs, J. Perry, 2018, Bioorganic & medicinal chemistry.

Synthesis and testing of chromogenic phenoxazinone substrates for beta-alanyl aminopeptidase.

Rosaleen J. Anderson, P. Groundwater, J. Perry, 2008, Organic and biomolecular chemistry.

The synthesis of spacer molecules containing an alcohol group at each terminus

P. Groundwater, D. Butler, R. Warrener, 1991 .

A Selective, Dual Emission β-Alanine Aminopeptidase Activated Fluorescent Probe for the Detection of Pseudomonas aeruginosa, Burkholderia cepacia, and Serratia marcescens

P. Groundwater, D. Hibbs, J. Perry, 2019, Molecules.

A Selective, Dual Emission β -Alanine Aminopeptidase Activated Fluorescent Probe for the Detection of Pseudomonas aeruginosa , Burkholderia , and Serratia

P. Groundwater, D. Hibbs, J. Perry, 2019 .

Methods for the detection and identification of pathogenic bacteria: past, present, and future.

Rosaleen J. Anderson, Linda Váradi, Jia Lin Luo, 2017, Chemical Society reviews.

Synthesis and Evaluation of Novel 7- and 8-Aminophenoxazinones for the Detection of β-Alanine Aminopeptidase Activity and the Reliable Identification of Pseudomonas aeruginosa in Clinical Samples.

Rosaleen J. Anderson, P. Groundwater, J. Perry, 2016, Journal of medicinal chemistry.

The photo-epimerisation of gossypol Schiff's bases

P. Groundwater, R. Fish, J. Morgan, 1995 .

Azone® induced fluidity in human stratum corneum. A fourier transform infrared spectroscopy investigation using the perdeuterated analogue

P. Groundwater, J. Hadgraft, K. Brain, 1996 .

Synthesis of diacylated γ-glutamyl-cysteamine prodrugs, and in vitro evaluation of their cytotoxicity and intracellular delivery of cysteamine.

Rosaleen J. Anderson, P. Groundwater, P. Hambleton, 2016, European journal of medicinal chemistry.

The Synthesis of Spacer Molecules Containing an Alcohol Group at Each Terminus.

P. Groundwater, D. Butler, R. Russell, 1992 .

A New and Convenient Synthesis of 1-Aryl-2-dimethylaminoethanols

P. Groundwater, I. Fejes, M. Nyerges, 2001 .

Quinolone Antibacterial Agents

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Targeting the thioredoxin system in the treatment of certain cancers

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2010 .

Structure-activity studies on gossypol in tumor cell lines

P. Groundwater, M. Shelley, R. Fish, 2000, Anti-cancer drugs.

Ultraviolet–visible (UV-Vis) spectroscopy

Rosaleen J. Anderson, P. Groundwater, D. Bendell, 2004 .

Identification of dual PPARα/γ agonists and their effects on lipid metabolism.

P. Groundwater, D. Hibbs, A. Hoy, 2015, Bioorganic & medicinal chemistry.

New Delhi metallo-β-lactamase-1: structure, inhibitors and detection of producers.

P. Groundwater, D. Hibbs, J. Perry, 2016, Future medicinal chemistry.

5.2. Glycopeptide Antibiotics

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2012 .

Drug Targets for Biologics

P. Groundwater, D. Hibbs, J. Hanrahan, 2020 .

Synthesis and biological testing ofpyrano[2,3-a]acridinones

P. Groundwater, J. Drewe, 1997 .

Chemo- and regioselectivity in the reactions of polyfunctional pyrroles

Rosaleen J. Anderson, P. Groundwater, G. Marth, 2010 .

Phytotherapy Pharmacophores for Major Cellular Drug Targets

P. Groundwater, D. Hibbs, Jennifer A. Ong, 2015 .

Two new ceramides from the fruit pulp of Acanthopanax senticosus (Rupr. et Maxim) Harms

P. Groundwater, R. Narlawar, Jinping Liu, 2014, Natural product research.

A Carbocyclic Curcumin Inhibits Proliferation of Gram-Positive Bacteria by Targeting FtsZ.

P. Groundwater, D. Hibbs, M. Doddareddy, 2017, Biochemistry.

Kavalactone pharmacophores for major cellular drug targets.

P. Groundwater, R. Narlawar, I. Ramzan, 2011, Mini reviews in medicinal chemistry.

Photolysis of fluorodiphenylamines

P. Groundwater, M. Hursthouse, David D. Hughes, 1996 .

Using Electron Density to Predict Synthon Formation in a 4-Hydroxybenzoic Acid: 4,4′-Bipyridine Cocrystal

Peter A. Williams, J. Platts, P. Groundwater, 2018 .

Exploring the Solubility of the Carbamazepine–Saccharin Cocrystal: A Charge Density Study

Peter A. Williams, J. Platts, P. Groundwater, 2018, Crystal Growth & Design.

An analysis of the experimental and theoretical charge density distributions of the piroxicam–saccharin co-crystal and its constituents

Peter A. Williams, J. Platts, P. Groundwater, 2016 .

Monoclinic Paracetamol vs. Paracetamol-4,4′-Bipyridine Co-Crystal; What Is the Difference? A Charge Density Study

Peter A. Williams, J. Platts, P. Groundwater, 2018 .

Current advances and research in the treatment of pancreatic cancer.

Rosaleen J. Anderson, P. Groundwater, A. Todd, 2010 .

An overview of cancer treatments

P. Groundwater, A. Moore, A. Todd, 2009 .

Novel diagnostics for point-of-care bacterial detection and identification

P. Groundwater, D. Hibbs, Linda Váradi, 2019, RSC advances.

Alteration ofserumandurinary lipolytic activity withweight loss in cachectic cancerpatients

I. Ferrier, P. Groundwater, M. Tisdale, 1990 .

Analyzing Hydration Differences in Cocrystal Polymorphs: High-Resolution X-ray Investigation of Caffeine–Glutaric Acid Cocrystals

J. Platts, P. Groundwater, D. Hibbs, 2021, Crystal Growth & Design.

Exploring the Binding of Barbital to a Synthetic Macrocyclic Receptor. A Charge Density Study.

Peter A. Williams, J. Platts, P. Groundwater, 2018, The journal of physical chemistry. A.

Experimental and theoretical charge density distribution in a host-guest system: synthetic terephthaloyl receptor complexed to adipic acid.

J. Platts, P. Groundwater, D. Hibbs, 2012, The journal of physical chemistry. A.

Identification of indolyl‐3‐acryloylglycine in the urine of people with autism

Rosaleen J. Anderson, W. J. Lough, P. Groundwater, 2002, The Journal of pharmacy and pharmacology.

An investigation of the scope of the 1,7-electrocyclization of α,β:γ,δ-conjugated azomethine ylides

Rosaleen J. Anderson, J. Platts, P. Groundwater, 2014 .

A one-step route to azomethine ylides via chloroiminium salts

Rosaleen J. Anderson, P. Groundwater, A. Batsanov, 2004 .

Substituent effects on the 4π + 2π cycloadditions of 4H-pyran-4-one derivatives

P. Groundwater, I. Fejes, M. Nyerges, 1999 .

A convenient regioselective synthesis of pyrano[3,2-b]acridones involving nucleophilic addition to benzyne

P. Groundwater, M. Nyerges, B. Pete, 1999 .

The design and synthesis of selective inhibitors for the insulin tyrosine kinase receptor

P. Groundwater, S. Mackay, J. McKiernan, 1998 .

Heterocycle-Fused Acridines

P. Groundwater, M. Munawar, 1997, Advances in Heterocyclic Chemistry.

The cyclisation of benzonitrile 3,3-diarylallyl ylides to give 3H-2-benzazepines: substituent directive effects and mechanism

P. Groundwater, J. Sharp, 1987 .

Correction: Experimental and theoretical charge density distribution in Pigment Yellow 101.

J. Platts, P. Groundwater, D. Hibbs, 2015, Physical chemistry chemical physics : PCCP.

The Cyclization of Benzonitrile 3,3-Diarylallyl Ylides to give 3H-2-Benzazepines: Substituent Directive Effects and Mechanism.

P. Groundwater, J. Sharp, 1987 .

The pentacyclic triterpenoids in herbal medicines and their pharmacological activities in diabetes and diabetic complications.

P. Groundwater, K. Hamid, V. Razmovski-Naumovski, 2013, Current medicinal chemistry.

1,7-Electrocyclisation of non-stabilised α,β∶γ,δ-unsaturated azomethine ylides

P. Groundwater, I. Garnett, M. Nyerges, 1999 .

Can we Predict Drug Excretion into Saliva? A Systematic Review and Analysis of Physicochemical Properties.

P. Groundwater, Bryson A. Hawkins, Thi A Nguyen, 2024, Clinical pharmacokinetics.