B. Aggarwal

B. Aggarwal, M. Chaturvedi, S. Singh, 1998, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Effect of cell cycle on the regulation of the cell surface and secreted forms of type I and type II human tumor necrosis factor receptors

B. Aggarwal, H. Loetscher, H. Gallati, 1995, Journal of cellular biochemistry.

Characterization of the apoptotic effects of human tumor necrosis factor: development of highly rapid and specific bioassay for human tumor necrosis factor and lymphotoxin using human target cells.

B. Aggarwal, M. Higuchi, S. Singh, 1995, Journal of immunological methods.

Leukemia inhibitory factor binds to human breast cancer cells and stimulates their proliferation.

Z. Estrov, B. Aggarwal, A. Sahin, 1995, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

and differentiation induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, Protease inhibitors differentially regulate tumor necrosis factor-

B. Aggarwal, Sanjaya Singh, M. Higuchi, 2011 .

Protease inhibitors differentially regulate tumor necrosis factor-induced apoptosis, nuclear factor-kappa B activation, cytotoxicity, and differentiation.

B. Aggarwal, M. Higuchi, S. Singh, 1995, Blood.

P80 form of the human tumor necrosis factor receptor is involved in DNA fragmentation

B. Aggarwal, M. Higuchi, 1993, FEBS letters.

Interferon‐γ induces cell surface expression for both types of tumor necrosis factor receptors

B. Aggarwal, R. Pandita, É. Pócsik, 1992 .

Increased lymphotoxin in human malarial serum, and the ability of this cytokine to increase plasma interleukin-6 and cause hypoglycaemia in mice: implications for malarial pathology.

B. Aggarwal, A. Ferrante, I. Clark, 1992, Transactions of the Royal Society of Tropical Medicine and Hygiene.

Cyclodextrin-complexed curcumin exhibits anti-inflammatory and antiproliferative activities superior to those of curcumin through higher cellular uptake.

B. Aggarwal, R. Kannappan, S. Prasad, 2010, Biochemical pharmacology.

1′-Acetoxychavicol Acetate Inhibits RANKL–Induced Osteoclastic Differentiation of RAW 264.7 Monocytic Cells by Suppressing Nuclear Factor-κB Activation

B. Aggarwal, A. Murakami, H. Ichikawa, 2006, Molecular Cancer Research.

belin Suppresses Osteoclastogenesis Induced by Receptor ivator of NF-κB Ligand and Tumor Cells In vitro through

B. Aggarwal, R. Yadav, R. Kannappan, 2010 .

Evidence that activation of nuclear factor-kappaB is essential for the cytotoxic effects of doxorubicin and its analogues.

B. Aggarwal, S. Shishodia, W. Priebe, 2004, Biochemical pharmacology.

Cytotoxins and immunotoxins for cancer therapy

R. Puri, B. Aggarwal, K. Kawakami, 2015 .

Cytotoxins and Immunotoxins for Cancer Therapy : Clinical Applications

R. Puri, B. Aggarwal, K. Kawakami, 2004 .

IFN-alpha suppresses activation of nuclear transcription factors NF-kappa B and activator protein 1 and potentiates TNF-induced apoptosis.

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, Journal of immunology.

Curcumin induces the degradation of cyclin E expression through ubiquitin-dependent pathway and up-regulates cyclin-dependent kinase inhibitors p21 and p27 in multiple human tumor cell lines.

Sanjeev Banerjee, B. Aggarwal, G. Sethi, 2007, Biochemical pharmacology.

γ-Tocotrienol Promotes TRAIL-Induced Apoptosis through Reactive Oxygen Species/Extracellular Signal-Regulated Kinase/p53–Mediated Upregulation of Death Receptors

B. Aggarwal, R. Kannappan, S. Prasad, 2010, Molecular Cancer Therapeutics.

Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.

B. Aggarwal, R. Kannappan, C. Sundaram, 2010, Biochemical pharmacology.

Curcumin downregulates cell survival mechanisms in human prostate cancer cell lines

B. Aggarwal, P. Pantazis, C. Bueso-Ramos, 2001, Oncogene.

Sesamin Manifests Chemopreventive Effects through the Suppression of NF-κB–Regulated Cell Survival, Proliferation, Invasion, and Angiogenic Gene Products

B. Aggarwal, K. Harikumar, B. Sung, 2010, Molecular Cancer Research.

Interrelationships of human interferon-gamma with lymphotoxin and monocyte cytotoxin

B. Aggarwal, J. Vilček, D. Henriksen-DeStefano, 1984, The Journal of experimental medicine.

Characterization of human tumor necrosis factor produced by peripheral blood monocytes and its separation from lymphotoxin

B. Aggarwal, J. Vilček, D. Henriksen-DeStefano, 1985, International journal of cancer.

Curcumin (Diferuloylmethane) inhibition of tumor necrosis factor (TNF)-mediated adhesion of monocytes to endothelial cells by suppression of cell surface expression of adhesion molecules and of nuclear factor-kappaB activation.

B. Aggarwal, Ashok J. Kumar, S. Dhawan, 1998, Biochemical pharmacology.

Suppression of antiproliferative effects of tumor necrosis factor by transfection of cells with human platelet‐derived growth factor B/c‐sis gene

B. Aggarwal, F. Ali-Osman, K. Totpal, 1995, FEBS letters.

Mechanisms of Regulation of Cell Growth by Cytokines of the Immune System

B. Aggarwal, K. Totpal, 1994 .

Phosphatase inhibitors modulate the growth-regulatory effects of human tumor necrosis factor on tumor and normal cells.

B. Aggarwal, K. Totpal, S. Agarwal, 1992, Cancer research.

Curcumin is a non‐competitive and selective inhibitor of phosphorylase kinase

B. Aggarwal, S. Reddy, 1994, FEBS letters.

Inhibition by all‐trans‐retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages

B. Aggarwal, T. McQueen, K. Mehta, 1994, Journal of leukocyte biology.

Multitargeting by turmeric, the golden spice: From kitchen to clinic.

B. Aggarwal, J. Kim, S. Prasad, 2013, Molecular nutrition & food research.

Down-regulation of Integrin αvβ3 Expression and Integrin-mediated Signaling in Glioma Cells by Adenovirus-mediated Transfer of Antisense Urokinase-type Plasminogen Activator Receptor (uPAR) and Sense p16 Genes*

G. Kouraklis, B. Aggarwal, C. Gondi, 2001, The Journal of Biological Chemistry.

Downregulation of integrin α v β 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense uPAR and sense p 16 genes

T. Tamiya, B. Aggarwal, C. Gondi, 2001 .

Zerumbone enhances TRAIL-induced apoptosis through the induction of death receptors in human colon cancer cells: Evidence for an essential role of reactive oxygen species.

B. Aggarwal, B. Sung, P. Limtrakul, 2009, Cancer research.

Recombinant DNA-derived methionyl human growth hormone is similar in membrane binding properties to human pituitary growth hormone.

B. Aggarwal, R. Hintz, R. Rosenfeld, 1982, Biochemical and biophysical research communications.

Retinoids downregulate both p60 and p80 forms of tumor necrosis factor receptors in human histiocytic lymphoma U-937 cells.

B. Aggarwal, R. Lapushin, K. Totpal, 1995, Blood.

Alpha-lipoic acid is a potent inhibitor of NF-kappa B activation in human T cells.

B. Aggarwal, L. Packer, Y. Suzuki, 1992, Biochemical and biophysical research communications.

Tumor necrosis factors. Structure, function, and mechanism of action.

B. Aggarwal, J. Vilček, 1992, Immunology series.

Suramin inhibits tumor cell cytotoxicity mediated through natural killer cells, lymphokine-activated killer cells, monocytes, and tumor necrosis factor

B. Aggarwal, R. Lapushin, K. Totpal, 2005, Journal of Clinical Immunology.

Role of Curcumin, the Golden Spice, in Obesity and Associated Chronic Diseases

B. Aggarwal, S. Prasad, Sridevi Patchva, 2012 .

Effect of phorbol esters on down-regulation and redistribution of cell surface receptors for tumor necrosis factor-alpha.

B. Aggarwal, T. Eessalu, 1987, The Journal of biological chemistry.

Curcumin selectively induces apoptosis in cutaneous T-cell lymphoma cell lines and patients' PBMCs: potential role for STAT-3 and NF-kappaB signaling.

B. Aggarwal, X. Zhang, M. Duvic, 2010, The Journal of investigative dermatology.

HIV-1 tat gene induces tumor necrosis factor-beta (lymphotoxin) in a human B-lymphoblastoid cell line.

B. Aggarwal, R. Pandita, K. Totpal, 1990, The Journal of biological chemistry.

1 Resveratrol: A Polyphenol for All Seasons

B. Aggarwal, S. Shishodia, 2006 .

Human tumour necrosis factor: precursor structure, expression and homology to lymphotoxin

Bharat B. Aggarwal, Peter H. Seeburg, P. Seeburg, 1984, Nature.

Balancing TNFR 1 and TNFR 2 Jointly for Joint Inflammation

B. Aggarwal, 2014 .

Editorial: Balancing Tumor Necrosis Factor Receptor I and Tumor Necrosis Factor Receptor II Jointly for Joint Inflammation

B. Aggarwal, 2014, Arthritis & rheumatology.

TNF-alpha-induced mitochondrial alterations in human T cells requires FADD and caspase-8 activation but not RIP and caspase-3 activation.

M. Shakibaei, B. Aggarwal, G. Sethi, 2010, Antioxidants & redox signaling.

TNF- a -Induced Mitochondrial Alterations in Human T Cells Requires FADD and Caspase-8 Activation but Not RIP and Caspase-3 Activation

M. Shakibaei, B. Aggarwal, G. Sethi, 2010 .

Autocrine lymphotoxin production in Epstein–Barr virus-immortalized B cells: induction via NF-κB activation mediated by EBV-derived latent membrane protein 1

Z. Estrov, B. Aggarwal, R. Kurzrock, 2003, Leukemia.

Transfection of cells with transforming growth factor‐α leads to cellular resistance to the antiproliferative effects of tumor necrosis factor

B. Aggarwal, F. Ali-Osman, K. Totpal, 1994, FEBS letters.

pp60ν‐src kinase overexpression leads to cellular resistance to the antiproliferative effects of tumor necrosis factor

B. Aggarwal, F. Ali-Osman, K. Totpal, 1994 .

Microtiter plate radioreceptor assay for tumor necrosis factor and its receptors in large numbers of samples.

B. Aggarwal, M. Higuchi, 1992, Analytical biochemistry.

Tumor necrosis factor-alpha exhibits greater proinflammatory activity than lymphotoxin in vitro.

C. Desch, B. Aggarwal, J. Harlan, 1990, Blood.

Characterization of recombinant human lymphotoxin (tumor necrosis factor-beta) produced by a mammalian cell line.

B. Aggarwal, J. Hains, 1989, Archives of biochemistry and biophysics.

Receptor Binding and Activation of Polymorphonuclear Neutrophils by Tumor Necrosis Factor‐Alpha

B. Aggarwal, M. Palladino, M. Shalaby, 1987, Journal of leukocyte biology.

Modulation of the Growth of Transformed Cells by Human Tumor Necrosis Factor-α and Interferon-γ

B. Aggarwal, H. Shepard, B. Sugarman, 1987 .

Human lymphotoxin. Production by a lymphoblastoid cell line, purification, and initial characterization.

B. Aggarwal, R. Harkins, B. Moffat, 1984, The Journal of biological chemistry.

Genetic Deletion of the Tumor Necrosis Factor Receptor p60 or p80 Abrogates Ligand-mediated Activation of Nuclear Factor-κB and of Mitogen-activated Protein Kinases in Macrophages*

J. Suttles, B. Aggarwal, A. Mukhopadhyay, 2001, The Journal of Biological Chemistry.

Editor's Note: γ-Tocotrienol Inhibits Pancreatic Tumors and Sensitizes Them to Gemcitabine Treatment by Modulating the Inflammatory Microenvironment.

B. Aggarwal, B. Sung, A. Kunnumakkara, 2018, Cancer research.

ocotrienol Inhibits Pancreatic Tumors and Sensitizes m to Gemcitabine Treatment by Modulating the R mmatory Microenvironment

B. Aggarwal, Z. Tong, B. Sung, 2010 .

Protein-tyrosine Phosphatase Inhibitors Block Tumor Necrosis Factor-dependent Activation of the Nuclear Transcription Factor NF-B (*)

B. Aggarwal, Sanjaya Singh, 1995, The Journal of Biological Chemistry.

Pervanadate-induced Nuclear Factor-κB Activation Requires Tyrosine Phosphorylation and Degradation of IκBα

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of Biological Chemistry.

Human immunodeficiency virus‐1‐tat induces matrix metalloproteinase‐9 in monocytes through protein tyrosine phosphatase‐mediated activation of nuclear transcription factor NF‐κB

B. Aggarwal, A. Mukhopadhyay, Ashok J. Kumar, 1999 .

VEGI, a new member of the TNF family activates Nuclear Factor-κB and c-Jun N-terminal kinase and modulates cell growth

B. Aggarwal, R. Gentz, S. Ruben, 1999, Oncogene.

Suppression of tumor necrosis factor-activated nuclear transcription factor-κB, activator protein-1, c-Jun N-terminal kinase, and apoptosis by β-lapachone

S. Manna, B. Aggarwal, A. Mukhopadhyay, 1999 .

Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-κB, degradation of IκBα, nuclear translocation of p65, and subsequent gene expression

S. Manna, B. Aggarwal, M. Chaturvedi, 1998 .

Inhibition of protein tyrosine phosphatases causes phosphorylation of tyrosine‐331 in the p60 TNF receptor and inactivates the receptor‐associated kinase

B. Aggarwal, B. Darnay, Bryant G Darnay, 1997, FEBS letters.

Effect of tumor necrosis factors, interferons, interleukins, and growth factors on the activation of NF-kappa B: evidence for lack of correlation with cell proliferation.

B. Aggarwal, M. Chaturvedi, M. Higuchi, 1994, Lymphokine and cytokine research.

Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-kappaB (NF-kappaB) activation and NF-kappaB-regulated gene expression.

B. Jayaprakasam, M. Nair, B. Aggarwal, 2006, Molecular cancer therapeutics.

Thiocolchicoside Exhibits Anticancer Effects through Downregulation of NF-κB Pathway and Its Regulated Gene Products Linked to Inflammation and Cancer

B. Aggarwal, R. Kannappan, S. Prasad, 2010, Cancer Prevention Research.

colchicoside Exhibits Anticancer Effects through nregulation of NF-κB Pathway and Its Regulated Gene

B. Aggarwal, S. Prasad, B. Sung, 2010 .

Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates TNF-induced NF-kappa B activation through inhibition of activation of I kappa B alpha kinase and Akt in human non-small cell lung carcinoma: correlation with suppression of COX-2 synthesis.

B. Aggarwal, S. Shishodia, D. Koul, 2004, Journal of immunology.

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-kappaB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation.

B. Aggarwal, A. Bhardwaj, Y. Takada, 2004, Oncogene.

Bcl-2 overexpression protects photooxidative stress-induced apoptosis of photoreceptor cells via NF-kappaB preservation.

B. Aggarwal, M. Al-Ubaidi, R. Collier, 2001, Biochemical and biophysical research communications.

Ectopic expression of protein-tyrosine kinase Bcr-Abl suppresses tumor necrosis factor (TNF)-induced NF-kappa B activation and IkappaBalpha phosphorylation. Relationship with down-regulation of TNF receptors.

J. Suttles, B. Aggarwal, K. Bhalla, 2002, The Journal of biological chemistry.

Myeloma Cells Phosphorylation in Human Multiple Constitutive and IL-6-Inducible STAT3 Curcumin (Diferuloylmethane) Inhibits

B. Aggarwal, N. Donato, A. Bharti, 2003 .

TNF induces internalization of the p60 receptor and shedding of the p80 receptor.

B. Aggarwal, M. Higuchi, 1994, Journal of immunology.

Regulation of two forms of the TNF receptors by phorbol ester and dibutyryl cyclic adenosine 3',5'-monophosphate in human histiocytic lymphoma cell line U-937.

W. Liao, B. Aggarwal, M. Higuchi, 1993, Lymphokine and cytokine research.

Role of Protein Kinases and Phosphatases in Receptor Biosynthesis, Shedding and Mediation of Cellular Responses to Tumor Necrosis Factor

W. Liao, B. Aggarwal, K. Totpal, 1993 .

A Novel Pentamethoxyflavone Down-Regulates Tumor Cell Survival and Proliferative and Angiogenic Gene Products through Inhibition of I (cid:1) B Kinase Activation and Sensitizes Tumor Cells to Apoptosis by Cytokines and Chemotherapeutic Agents

B. Aggarwal, R. Kannappan, S. Prasad, 2011 .

Genetic deletion of PKR abrogates TNF-induced activation of IkappaBalpha kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation.

S. Swisher, B. Aggarwal, Y. Takada, 2007, Oncogene.

Wortmannin inhibits activation of nuclear transcription factors NF‐κB and activated protein‐1 induced by lipopolysaccharide and phorbol ester

S. Manna, B. Aggarwal, 2000, FEBS letters.

Curcumin and colorectal cancer: Add spice to your life

B. Aggarwal, A. Kunnumakkara, S. Guha, 2009 .

Curcumin downregulates human tumor necrosis factor-α levels: A systematic review and meta-analysis ofrandomized controlled trials.

A. Sahebkar, B. Aggarwal, Subash C. Gupta, 2016, Pharmacological research.

Erratum: Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-κB signalling (International Journal of Cancer (2004) 111 (679-692))

Sujay K. Singh, B. Aggarwal, J. Myers, 2004 .

Genetic deletion of glycogen synthase kinase-3beta abrogates activation of IkappaBalpha kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by tumor necrosis factor.

B. Aggarwal, Y. Takada, X. Fang, 2004, The Journal of biological chemistry.

Googling the Guggul (Commiphora and Boswellia) for Prevention of Chronic Diseases

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2018, Front. Pharmacol..

Osteoclast Precursors and Suppresses B Activation in κ Ligand-Induced NF- B κ Receptor Activator of NF- Curcumin (Diferuloylmethane) Inhibits

B. Aggarwal, Y. Takada, A. Bharti, 2013 .

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

Gamma tocotrienol and prostate cancer: The regulation of two independent pathways to potentiate cell growth inhibition and apoptosis

B. Aggarwal, L. Leesnitzer, S. Blanchard, 2008 .

Cancer is a Preventable Disease that Requires Major Lifestyle Changes

B. Aggarwal, K. Harikumar, B. Sung, 2008, Pharmaceutical Research.

Site-specific tyrosine phosphorylation of IkappaBalpha negatively regulates its inducible phosphorylation and degradation.

B. Aggarwal, B. Darnay, S. Singh, 1996, The Journal of biological chemistry.

Altered actin cytoskeleton and inhibition of matrix metalloproteinase expression by vanadate and phenylarsine oxide, inhibitors of phosphotyrosine phosphatases: Modulation of migration and invasion of human malignant glioma cells

W. Yung, J. Uhm, Raymond Sawaya, 1999, Molecular carcinogenesis.

Functional expression of receptor activator of nuclear factor kappaB in Hodgkin disease cell lines.

B. Aggarwal, A. Gillenwater, F. Cabanillas, 2001, Blood.

Activation of NF-κB by RANK Requires Tumor Necrosis Factor Receptor-associated Factor (TRAF) 6 and NF-κB-inducing Kinase

B. Aggarwal, P. Moore, J. Ni, 1999, The Journal of Biological Chemistry.

Characterization of the Intracellular Domain of Receptor Activator of NF-κB (RANK)

B. Aggarwal, P. Moore, J. Ni, 1998, The Journal of Biological Chemistry.

Characterization of the intracellular domain of receptor activator of NF-kappaB (RANK). Interaction with tumor necrosis factor receptor-associated factors and activation of NF-kappab and c-Jun N-terminal kinase.

B. Aggarwal, P. Moore, Jian Ni, 1998, The Journal of biological chemistry.

Multifunctionality of Calebin A in inflammation, chronic diseases and cancer

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2022, Frontiers in Oncology.

Boswellic acid inhibits growth and metastasis of human colorectal cancer in orthotopic mouse model by downregulating inflammatory, proliferative, invasive and angiogenic biomarkers

B. Aggarwal, S. Prasad, B. Sung, 2012, International journal of cancer.

Acetyl-11-Keto- B -Boswellic Acid Inhibits Prostate Tumor Growth by Suppressing Vascular Endothelial Growth Factor Receptor 2–Mediated Angiogenesis Experimental Therapeutics, Molecular Targets, and Chemical Biology

Mingyao Liu, Xiufeng Pang, Z. Yi, 2009 .

Apoptosis and nuclear factor-kappa B: a tale of association and dissociation.

B. Aggarwal, 2000, Biochemical pharmacology.

Methotrexate suppresses NF-kappaB activation through inhibition of IkappaBalpha phosphorylation and degradation.

B. Aggarwal, S. Majumdar, 2001, Journal of immunology.

Mending the bones with natural products.

B. Aggarwal, G. Sethi, 2007, Chemistry & biology.

Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2

M. Shakibaei, B. Aggarwal, B. Popper, 2020, Cell and Tissue Research.

Leading to TNF-Induced MAPK Activation, TNF Activates Syk Protein Tyrosine Kinase

B. Aggarwal, Y. Takada, 2004 .

Cigarette smoke condensate activates nuclear transcription factor-κB through phosphorylation and degradation of IκBα: correlation with induction of cyclooxygenase-2

B. Aggarwal, S. Shishodia, A. Mukhopadhyay, 2002 .

Modification of cysteine residue in p65 subunit of nuclear factor-kappaB (NF-kappaB) by picroliv suppresses NF-kappaB-regulated gene products and potentiates apoptosis.

B. Aggarwal, K. Ahn, K. Harikumar, 2008, Cancer research.

Modulation of receptors and cytotoxic response of tumor necrosis factor-alpha by various lectins.

B. Aggarwal, T. Eessalu, P. Traquina, 1986, The Journal of biological chemistry.

Natural killer-sensitive targets stimulate production of TNF-alpha but not TNF-beta (lymphotoxin) by highly purified human peripheral blood large granular lymphocytes.

D. Goeddel, B. Aggarwal, P. Hass, 1986, Journal of immunology.

Modification of the cysteine residues in I B kinase and NF-B ( p 65 ) by xanthohumol leads to suppression of NF-B – regulated gene products and potentiation of apoptosis in leukemia cells

B. Aggarwal, K. Ahn, K. Harikumar, 2009 .

Informetric Analysis on the International Retracted Publication Based on the Web of Science Database

B. Aggarwal, S. Radhakrishnan, R. Slutsky, 2019 .

Overexpression of tissue transglutaminase leads to constitutive activation of nuclear factor-kappaB in cancer cells: delineation of a novel pathway.

B. Aggarwal, G. Sethi, Huamin Wang, 2006, Cancer research.

The Potential Role of Curcumin for Treatment of Pancreatic Cancer

B. Aggarwal, S. Guha, M. Kanai, 2012 .

Serendipity in Cancer Drug Discovery: Rational or Coincidence?

Sahdeo Prasad, B. Aggarwal, S. Prasad, 2016, Trends in pharmacological sciences.

The therapeutic effects of rGel/BLyS fusion toxin in in vitro and in vivo models of mantle cell lymphoma.

B. Aggarwal, K. Ahn, W. Hittelman, 2012, Biochemical pharmacology.

Butein Suppresses Constitutive and Inducible Signal Transducer and Activator of Transcription (STAT) 3 Activation and STAT3-Regulated Gene Products through the Induction of a Protein Tyrosine Phosphatase SHP-1

B. Aggarwal, K. Ahn, B. Sung, 2009, Molecular Pharmacology.

Curcumin improves the therapeutic efficacy of Listeriaat-Mage-b vaccine in correlation with improved T-cell responses in blood of a triple-negative breast cancer model 4T1

B. Aggarwal, D. Chandra, X. Zang, 2013, Cancer medicine.

Induction of Cell Cycle Arrest and Apoptosis by the Proteasome Inhibitor PS-341 in Hodgkin Disease Cell Lines Is Independent of Inhibitor of Nuclear Factor-κB Mutations or Activation of the CD30, CD40, and RANK Receptors

B. Aggarwal, D. McConkey, G. Georgakis, 2004, Clinical Cancer Research.

Cooperation of imipramine blue and tyrosine kinase blockade demonstrates activity against chronic myeloid leukemia

B. Aggarwal, J. Arbiser, T. Holyoake, 2016, Oncotarget.

Curcumin glucuronides: assessing the proliferative activity against human cell lines.

B. Aggarwal, W. Bornmann, S. Prasad, 2014, Bioorganic & medicinal chemistry.

Turmeric, the Golden Spice

B. Aggarwal, S. Prasad, 2011 .

Curcumin Derived from Turmeric ( Curcuma longa ): a Spice for All Seasons

B. Aggarwal, S. Shishodia, M. Aggarwal, 2005 .

Tumor necrosis factors α and β differ in their capacities to generate interleukin 1 release from human endothelial cells

R. Locksley, B. Aggarwal, H. Shepard, 1987 .

Suppression of pro-inflammatory and proliferative pathways by diferuloylmethane (curcumin) and its analogues dibenzoylmethane, dibenzoylpropane, and dibenzylideneacetone: role of Michael acceptors and Michael donors.

B. Aggarwal, B. Sung, A. Kunnumakkara, 2011, Biochemical pharmacology.

Noscapine, a benzylisoquinoline alkaloid, sensitizes leukemic cells to chemotherapeutic agents and cytokines by modulating the NF-kappaB signaling pathway.

B. Aggarwal, K. Ahn, B. Sung, 2010, Cancer research.

Kinase and Activator Protein-1 HIV-Tat Protein Activates c-Jun N-Terminal

S. Manna, B. Aggarwal, S. Dhawan, 1998 .

WITHDRAWN: Evidence for the critical roles of NF-κB p65 and specificity proteins in the apoptosis-inducing activity of proteasome inhibitors in leukemia cells.

B. Aggarwal, R. Kannappan, Subash C. Gupta, 2012, Biochimica et biophysica acta.

Nuclear factor– (cid:1) B and STAT3 are constitutively active in CD138 (cid:2) cells derived from multiple myeloma patients, and suppression of these transcription factors leads to apoptosis

Z. Estrov, B. Aggarwal, S. Shishodia, 2022 .

Curcumin hormesis mediates a cross-talk between autophagy and cell death

L. Motte, B. Aggarwal, P. Petit, 2015, Cell Death and Disease.

Differential roles of two types of the TNF receptor in TNF-induced cytotoxicity, DNA fragmentation, and differentiation.

B. Aggarwal, M. Higuchi, Masahiro Higuchi, 1994, Journal of immunology.

multiple myeloma cells B-regulated antiapoptotic and cell survival gene products in human κ chemoresistance through downregulation of STAT3 and nuclear factor- Resveratrol inhibits proliferation, induces apoptosis and overcomes

B. Aggarwal, G. Sethi, S. Shishodia, 2013 .

Caffeic acid phenethyl ester is a potent and specific inhibitor of activation of nuclear transcription factor NF-kappa B.

B. Aggarwal, T. Burke, Sanjaya Singh, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Berberine modifies cysteine 179 of IkappaBalpha kinase, suppresses nuclear factor-kappaB-regulated antiapoptotic gene products, and potentiates apoptosis.

B. Aggarwal, G. Sethi, B. Sung, 2008, Cancer research.

Assay for redox-sensitive kinases.

B. Aggarwal, A. Kumar, 1999, Methods in enzymology.

Multitargeting by Curcumin as Revealed by Molecular Interaction Studies

B. Aggarwal, J. Kim, S. Prasad, 2012 .

Differential Requirement for p56lck in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis1

S. Manna, B. Aggarwal, 2000, The Journal of Immunology.

Differential Requirement for p56 in HIV-tat Versus TNF-Induced Cellular Responses: Effects on NF- kB, Activator Protein-1, c-Jun N-Terminal Kinase, and Apoptosis

S. Manna, B. Aggarwal, 2000 .

Fas antigen signals proliferation of normal human diploid fibroblast and its mechanism is different from tumor necrosis factor receptor

B. Aggarwal, R. Lapushin, Sanjaya Singh, 1995, FEBS letters.

TNF and its receptor antibody agonist differ in mediation of cellular responses.

B. Aggarwal, R. Lapushin, T. Kohno, 1994, Journal of immunology.

Zerumbone abolishes NF-kappaB and IkappaBalpha kinase activation leading to suppression of antiapoptotic and metastatic gene expression, upregulation of apoptosis, and downregulation of invasion.

B. Aggarwal, Y. Takada, A. Murakami, 2005, Oncogene.

Identification of a novel blocker of I kappa B alpha kinase that enhances cellular apoptosis and inhibits cellular invasion through suppression of NF-kappa B-regulated gene products.

B. Aggarwal, Y. Takada, A. Murakami, 2005, Journal of immunology.

Serum cytokine levels in infectious mononucleosis at diagnosis and convalescence.

P. Thall, Z. Estrov, M. Jenkins, 1998, Leukemia & lymphoma.

Effects of histidine modification on the biological and immunological activities of equine chorionic gonadotropin.

B. Aggarwal, H. Papkoff, 1980, Archives of biochemistry and biophysics.

Role of histidine residues in ovine lutropin: effects on steroidogenic activity.

B. Aggarwal, H. Papkoff, 1979, Biochemical and biophysical research communications.

Evodiamine abolishes constitutive and inducible NF-kappaB activation by inhibiting IkappaBalpha kinase activation, thereby suppressing NF-kappaB-regulated antiapoptotic and metastatic gene expression, up-regulating apoptosis, and inhibiting invasion.

B. Aggarwal, Y. Takada, Yoshinori Kobayashi, 2005, The Journal of biological chemistry.

All-trans-retinoic acid upregulates TNF receptors and potentiates TNF-induced activation of nuclear factors-κB, activated protein-1 and apoptosis in human lung cancer cells

S. Manna, B. Aggarwal, 2000, Oncogene.

Inhibition of ligand binding and antiproliferative effects of tumor necrosis factor and lymphotoxin by soluble forms of recombinant P60 and P80 receptors.

B. Aggarwal, M. Higuchi, 1992, Biochemical and biophysical research communications.

Human immunodeficiency virus-1-tat induces matrix metalloproteinase-9 in monocytes through protein tyrosine phosphatase-mediated activation of nuclear transcription factor NF-kappaB.

B. Aggarwal, A. Mukhopadhyay, S. Dhawan, 1999, FEBS letters.

Chapter 5 – Chemosensitization by Ursolic Acid: A New Avenue for Cancer Therapy

B. Aggarwal, S. Prasad, A. Tyagi, 2018 .

Pervanadate-induced nuclear factor-kappaB activation requires tyrosine phosphorylation and degradation of IkappaBalpha. Comparison with tumor necrosis factor-alpha.

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of biological chemistry.

Bcl-x(L) suppresses TNF-mediated apoptosis and activation of nuclear factor-kappaB, activation protein-1, and c-Jun N-terminal kinase.

S. Manna, B. Aggarwal, V. Haridas, 2000, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Physical and functional association of a serine-threonine protein kinase to the cytoplasmic domain of the p80 form of the human tumor necrosis factor receptor in human histiocytic lymphoma U-937 cells.

B. Aggarwal, B. Darnay, S. Reddy, 1994, The Journal of biological chemistry.

Nonsteroidal anti-inflammatory agents differ in their ability to suppress NF-κB activation, inhibition of expression of cyclooxygenase-2 and cyclin D1, and abrogation of tumor cell proliferation

B. Aggarwal, A. Bhardwaj, Y. Takada, 2004, Oncogene.

The synergistic anti-proliferative effect of gamma-interferon and human lymphotoxin.

B. Aggarwal, S. Lee, E. Rinderknecht, 1984, Journal of immunology.

Constitutive Activation of NF-κB Causes Resistance to Apoptosis in Human Cutaneous T Cell Lymphoma HuT-78 Cells

B. Aggarwal, D. Giri, 1998, The Journal of Biological Chemistry.

Differential activation of the nuclear factor-kappa B by TNF muteins specific for the p60 and p80 TNF receptors.

B. Aggarwal, U. Raju, G. Chainy, 1996, Journal of immunology.

Determination and regulation of nitric oxide production from macrophages by lipopolysaccharides, cytokines, and retinoids.

B. Aggarwal, K. Mehta, 1996, Methods in enzymology.

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

B. Aggarwal, S. Prasad, L. Deb, 2014, Molecules.

Rese Thio Dow Pro Simon Rama Abst Intro

B. Aggarwal, S. Prasad, B. Sung, 2010 .

Tumor necrosis factor alpha induces gamma-glutamyltransferase expression via nuclear factor-kappaB in cooperation with Sp1.

Serge Eifes, B. Aggarwal, M. Diederich, 2009, Biochemical pharmacology.

Editor's Note: Curcumin Potentiates the Antitumor Effects of Bacillus Calmette-Guerin against Bladder Cancer through the Downregulation of NF-κB and Upregulation of TRAIL Receptors.

B. Aggarwal, B. Sung, A. Kamat, 2018, Cancer research.

Characterization and affinity cross-linking of receptors for human recombinant lymphotoxin (tumor necrosis factor-beta) on a human histiocytic lymphoma cell line, U-937.

B. Aggarwal, G. Stauber, 1989, The Journal of biological chemistry.

Enzyme levels of normal human cells: aging in culture.

B. Aggarwal, L. Packer, A. S. Sun, 1975, Archives of biochemistry and biophysics.

Alpha-melanocyte-stimulating hormone inhibits the nuclear transcription factor NF-kappa B activation induced by various inflammatory agents.

S. Manna, B. Aggarwal, 1998, Journal of immunology.

leading to suppression of proliferation and induction of apoptosis kinase in human multiple myeloma cells α B κ B and I κ nuclear factor Curcumin (Diferuloylmethane) downregulates the constitutive activation of

Sujay K. Singh, B. Aggarwal, N. Donato, 2013 .

Inhibition of IkB kinase and NF-kappaB by a novel synthetic compound SK 2009.

B. Aggarwal, K. Harikumar, Saeed R. Khan, 2010, Bioorganic & medicinal chemistry.

Historical perspectives on tumor necrosis factor and its superfamily: 25 years later, a golden journey.

B. Aggarwal, J. Kim, Subash C. Gupta, 2012, Blood.

Plumbagin (5-hydroxy-2-methyl-1,4-naphthoquinone) suppresses NF-kappaB activation and NF-kappaB-regulated gene products through modulation of p65 and IkappaBalpha kinase activation, leading to potentiation of apoptosis induced by cytokine and chemotherapeutic agents.

B. Aggarwal, G. Sethi, K. Ahn, 2006, The Journal of biological chemistry.

Anticancer potential of curcumin: preclinical and clinical studies.

B. Aggarwal, A. Bharti, Anushree Kumar, 2003, Anticancer research.

Activation of human polymorphonuclear neutrophil functions by interferon-gamma and tumor necrosis factors.

B. Aggarwal, M. Palladino, B. Finkle, 1985, Journal of immunology.

Cancer prevention with natural compounds.

F. Khuri, J. Pezzuto, D. Shin, 2010, Seminars in oncology.

Piperlongumine Chemosensitizes Tumor Cells through Interaction with Cysteine 179 of IκBα Kinase, Leading to Suppression of NF-κB–Regulated Gene Products

B. Aggarwal, S. Prasad, Subash C. Gupta, 2014, Molecular Cancer Therapeutics.

Hydrogen Peroxide Activates NF-κB through Tyrosine Phosphorylation of IκBα and Serine Phosphorylation of p65

Sujay K. Singh, B. Aggarwal, Y. Takada, 2003, Journal of Biological Chemistry.

Hydrogen peroxide activates NF-kappa B through tyrosine phosphorylation of I kappa B alpha and serine phosphorylation of p65: evidence for the involvement of I kappa B alpha kinase and Syk protein-tyrosine kinase.

Sujay K. Singh, B. Aggarwal, Y. Takada, 2003, The Journal of biological chemistry.

Targeting cell signaling pathways for drug discovery: An old lock needs a new key

V. Baladandayuthapani, B. Aggarwal, G. Sethi, 2007, Journal of cellular biochemistry.

TR1, a new member of the tumor necrosis factor receptor superfamily, induces fibroblast proliferation and inhibits osteoclastogenesis and bone resorption

B. Kwon, B. Aggarwal, J. Greene, 1998, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.

Sanjeev Banerjee, B. Aggarwal, C. Bueso-Ramos, 2002, Cancer research.

Design of curcumin-loaded PLGA nanoparticles formulation with enhanced cellular uptake, and increased bioactivity in vitro and superior bioavailability in vivo.

B. Aggarwal, B. Sung, A. Kunnumakkara, 2010, Biochemical pharmacology.

Crotepoxide Chemosensitizes Tumor Cells through Inhibition of Expression of Proliferation, Invasion, and Angiogenic Proteins Linked to Proinflammatory Pathway*

B. Aggarwal, S. Prasad, M. Chaturvedi, 2010, The Journal of Biological Chemistry.

Bioavailability of curcumin: problems and promises.

Robert A Newman, B. Aggarwal, A. Kunnumakkara, 2007, Molecular pharmaceutics.

ROS and CHOP are critical for dibenzylideneacetone to sensitize tumor cells to TRAIL through induction of death receptors and downregulation of cell survival proteins.

B. Aggarwal, S. Prasad, Jayaraj Ravindran, 2011, Cancer research.

Chemosensitization of tumors by resveratrol

B. Aggarwal, J. Kim, R. Kannappan, 2011, Annals of the New York Academy of Sciences.

Biological activities of curcumin and its analogues (Congeners) made by man and Mother Nature.

B. Aggarwal, K. Harikumar, B. Sung, 2008, Biochemical pharmacology.

Curcumin: the Indian solid gold.

B. Aggarwal, C. Sundaram, Bharat B Aggarwal, 2007, Advances in experimental medicine and biology.

C5-curcuminoid-dithiocarbamate based molecular hybrids: synthesis and anti-inflammatory and anti-cancer activity evaluation

B. Aggarwal, A. Tyagi, D. Rawat, 2014 .

Curcumin and Cancer Cells: How Many Ways Can Curry Kill Tumor Cells Selectively?

B. Aggarwal, S. Prasad, Jayaraj Ravindran, 2009, The AAPS Journal.

The role of chalcones in suppression of NF-κB-mediated inflammation and cancer.

B. Aggarwal, S. Prasad, B. Sung, 2011, International immunopharmacology.

TNF blockade: an inflammatory issue.

B. Aggarwal, G. Sethi, S. Shishodia, 2006, Ernst Schering Research Foundation workshop.

10 TNF Blockade : An Inflammatory Issue

B. Aggarwal, G. Sethi, S. Shishodia, 2005 .

Upsides and downsides of reactive oxygen species for cancer: the roles of reactive oxygen species in tumorigenesis, prevention, and therapy.

B. Aggarwal, Subash C. Gupta, Byoungduck Park, 2012, Antioxidants & redox signaling.

Curcumin and cancer: an "old-age" disease with an "age-old" solution.

B. Aggarwal, A. Kunnumakkara, P. Anand, 2008, Cancer letters.

Recombinant human tumor necrosis factor-alpha: effects on proliferation of normal and transformed cells in vitro.

B. Aggarwal, P. Hass, H. Shepard, 1985, Science.

Pharmacological basis for the role of curcumin in chronic diseases: an age-old spice with modern targets.

B. Aggarwal, B. Sung, Bokyung Sung, 2009, Trends in pharmacological sciences.

Epigenetic changes induced by curcumin and other natural compounds

Bharat B. Aggarwal, Ajay Goel, B. Aggarwal, 2011, Genes & Nutrition.

Anacardic acid (6-nonadecyl salicylic acid), an inhibitor of histone acetyltransferase, suppresses expression of nuclear factor-kappaB-regulated gene products involved in cell survival, proliferation, invasion, and inflammation through inhibition of the inhibitory subunit of nuclear factor-kappaBalp

B. Aggarwal, K. Ahn, Mingyao Liu, 2008, Blood.

Phenylarsine oxide blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, and induces apoptosis of acute myelogenous leukemia cells.

E. Estey, Z. Estrov, D. Harris, 1999, Blood.

“Spicing Up” of the Immune System by Curcumin

Bharat B. Aggarwal, B. Aggarwal, G. Jagetia, 2007, Journal of Clinical Immunology.

Transcription Factor NF‐κB: A Sensor for Smoke and Stress Signals

B. Aggarwal, K. Ahn, KWANG SEOK AHN, 2005 .

Nuclear factor-kappaB activation mediates cellular transformation, proliferation, invasion angiogenesis and metastasis of cancer.

B. Aggarwal, S. Shishodia, 2004, Cancer treatment and research.

Models for prevention and treatment of cancer: problems vs promises.

B. Aggarwal, Bharat B Aggarwal, P. Gehlot, 2009, Biochemical pharmacology.

Neem (Azadirachta indica): An indian traditional panacea with modern molecular basis.

B. Aggarwal, S. Prasad, Subash C. Gupta, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

COVID-19, cytokines, inflammation, and spices: How are they related?

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2021, Life Sciences.

Cancer drug development: The missing links

M. Shakibaei, B. Aggarwal, Subash C. Gupta, 2019, Experimental biology and medicine.

Nimbolide, a Limonoid Triterpene, Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proinflammatory Microenvironment

Y. Mo, B. Aggarwal, S. Prasad, 2013, Clinical Cancer Research.

Modification of Cysteine 179 of IκBα Kinase by Nimbolide Leads to Down-regulation of NF-κB-regulated Cell Survival and Proliferative Proteins and Sensitization of Tumor Cells to Chemotherapeutic Agents*

B. Aggarwal, R. Kannappan, S. Prasad, 2010, The Journal of Biological Chemistry.

Coronarin D, a labdane diterpene, inhibits both constitutive and inducible nuclear factor-κB pathway activation, leading to potentiation of apoptosis, inhibition of invasion, and suppression of osteoclastogenesis

B. Aggarwal, A. Kunnumakkara, P. Anand, 2008, Molecular Cancer Therapeutics.

Butein, a Tetrahydroxychalcone, Inhibits Nuclear Factor (NF)-κB and NF-κB-regulated Gene Expression through Direct Inhibition of IκBα Kinase β on Cysteine 179 Residue*

B. Aggarwal, G. Sethi, B. Sung, 2007, Journal of Biological Chemistry.

The molecular targets and therapeutic uses of curcumin in health and disease

B. Aggarwal, S. Shishodia, Y. Surh, 2007 .

Betulinic Acid Suppresses Carcinogen-Induced NF-κB Activation Through Inhibition of IκBα Kinase and p65 Phosphorylation: Abrogation of Cyclooxygenase-2 and Matrix Metalloprotease-9

B. Aggarwal, Y. Takada, 2003, The Journal of Immunology.

Multitargeting by curcumin as revealed by molecular interaction studies.

B. Aggarwal, J. Kim, S. Prasad, 2011, Natural product reports.

Natural products as a gold mine for arthritis treatment.

B. Aggarwal, G. Sethi, K. Ahn, 2007, Current opinion in pharmacology.

Therapeutic Roles of Curcumin: Lessons Learned from Clinical Trials

B. Aggarwal, Subash C. Gupta, Sridevi Patchva, 2012, The AAPS Journal.

A Dihydroxy-pentamethoxyflavone from Gardenia obtusifolia suppresses proliferation and promotes apoptosis of tumor cells through modulation of multiple cell signaling pathways.

B. Aggarwal, B. Sung, Simone Reuter, 2010, Anticancer research.

Plumbagin (5-Hydroxy-2-methyl-1,4-naphthoquinone) Suppresses NF-κB Activation and NF-κB-regulated Gene Products Through Modulation of p65 and IκBα Kinase Activation, Leading to Potentiation of Apoptosis Induced by Cytokine and Chemotherapeutic Agents*

B. Aggarwal, G. Sethi, K. Ahn, 2006, Journal of Biological Chemistry.

Role of resveratrol in prevention and therapy of cancer: preclinical and clinical studies.

N. Seeram, B. Aggarwal, S. Shishodia, 2004, Anticancer research.

Regulation of Inflammation-Mediated Chronic Diseases by Botanicals

B. Aggarwal, S. Prasad, Subash C. Gupta, 2012 .

Resveratrol Suppresses TNF-Induced Activation of Nuclear Transcription Factors NF-κB, Activator Protein-1, and Apoptosis: Potential Role of Reactive Oxygen Intermediates and Lipid Peroxidation1

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of Immunology.

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.

B. Aggarwal, Subash C. Gupta, Shiyou Li, 2013, Molecular nutrition & food research.

Curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ROS-independent mechanism.

B. Aggarwal, G. Sethi, K. Ahn, 2007, Carcinogenesis.

Curcumin as "Curecumin": from kitchen to clinic.

B. Aggarwal, A. Kunnumakkara, A. Goel, 2008, Biochemical pharmacology.

From chemoprevention to chemotherapy: common targets and common goals

B. Aggarwal, Y. Takada, O. Oommen, 2004, Expert opinion on investigational drugs.

Chronic diseases caused by chronic inflammation require chronic treatment: The anti-inflammatory lifestyle

B. Aggarwal, J. Kim, R. Kannappan, 2016 .

Targeting Inflammatory Pathways for Prevention and Therapy of Cancer: Short-Term Friend, Long-Term Foe

B. Aggarwal, B. Sung, R. Vijayalekshmi, 2009, Clinical Cancer Research.

From ancient medicine to modern medicine: ayurvedic concepts of health and their role in inflammation and cancer.

B. Aggarwal, G. Sethi, H. Ichikawa, 2007, Journal of the Society for Integrative Oncology.

Identification of a novel compound (β-sesquiphellandrene) from turmeric (Curcuma longa) with anticancer potential: comparison with curcumin

B. Aggarwal, S. Prasad, Shiyou Li, 2015, Investigational New Drugs.

From traditional Ayurvedic medicine to modern medicine: identification of therapeutic targets for suppression of inflammation and cancer

M. Nair, B. Aggarwal, G. Sethi, 2006, Expert opinion on therapeutic targets.

Potential of Spice-Derived Phytochemicals for Cancer Prevention

B. Aggarwal, K. Harikumar, B. Sung, 2008, Planta medica.

Thymoquinone inhibits tumor angiogenesis and tumor growth through suppressing AKT and extracellular signal-regulated kinase signaling pathways

Mingyao Liu, Xiufeng Pang, Z. Yi, 2008, Molecular Cancer Therapeutics.

Targeting Nuclear Factor-κB Activation Pathway by Thymoquinone: Role in Suppression of Antiapoptotic Gene Products and Enhancement of Apoptosis

B. Aggarwal, G. Sethi, K. Ahn, 2008, Molecular Cancer Research.

Curcumin suppresses proliferation and induces apoptosis in human biliary cancer cells through modulation of multiple cell signaling pathways.

B. Aggarwal, J. Kim, Subash C. Gupta, 2011, Carcinogenesis.

Cancer Cell Signaling Pathways Targeted by Spice-Derived Nutraceuticals

B. Aggarwal, S. Prasad, B. Sung, 2012, Nutrition and cancer.

21 Preventive and Therapeutic Effects of Plant Polyphenols through Suppression of Nuclear Factor-Kappa B

N. Seeram, B. Aggarwal, S. Shishodia, 2005 .

Withanolide sulfoxide from Aswagandha roots inhibits nuclear transcription factor‐kappa‐B, cyclooxygenase and tumor cell proliferation

M. Nair, B. Aggarwal, B. Sung, 2009, Phytotherapy research : PTR.

Withanolides potentiate apoptosis, inhibit invasion, and abolish osteoclastogenesis through suppression of nuclear factor-κB (NF-κB) activation and NF-κB–regulated gene expression

B. Jayaprakasam, M. Nair, B. Aggarwal, 2006, Molecular Cancer Therapeutics.

Targeting TNF for Treatment of Cancer and Autoimmunity.

B. Aggarwal, G. Sethi, B. Sung, 2009, Advances in experimental medicine and biology.

Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor–κB and IκBα kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis

Sujay K. Singh, B. Aggarwal, N. Donato, 2003 .

Inhibiting NF-κB activation by small molecules as a therapeutic strategy.

B. Aggarwal, Subash C. Gupta, Simone Reuter, 2010, Biochimica et biophysica acta.

Nuclear factor-κB: its role in health and disease

Bharat B. Aggarwal, B. Aggarwal, Ashok Kumar, 2004, Journal of Molecular Medicine.

Discovery of curcumin, a component of golden spice, and its miraculous biological activities

B. Aggarwal, Subash C. Gupta, Wonil Koh, 2012, Clinical and experimental pharmacology & physiology.

Molecular Targets of Nutraceuticals Derived from Dietary Spices: Potential Role in Suppression of Inflammation and Tumorigenesis

B. Aggarwal, K. Harikumar, B. Sung, 2009, Experimental biology and medicine.

Curcumin potentiates antitumor activity of gemcitabine in an orthotopic model of pancreatic cancer through suppression of proliferation, angiogenesis, and inhibition of nuclear factor-kappaB-regulated gene products.

B. Aggarwal, A. Kunnumakkara, S. Guha, 2007, Cancer research.

Cancer Prevention and Therapy

B. Aggarwal, J. Kim, S. Yoon, 2014, Integrative cancer therapies.

Curcumin‐induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IκB kinase and nuclear factor κB activity and are independent of the B‐Raf/mitogen‐activated/extracellular signal‐regulated protein kinase pathway and the Akt pathway

B. Aggarwal, R. Kurzrock, S. Shishodia, 2005, Cancer.

Potent Anti-Inflammatory Activity of Ursolic Acid, a Triterpenoid Antioxidant, Is Mediated through Suppression of NF-κB, AP-1 and NF-AT

B. Aggarwal, G. Sethi, K. Sainis, 2012, PloS one.

Vesnarinone Suppresses TNF-Induced Activation of NF-κB, c-Jun Kinase, and Apoptosis1

S. Manna, B. Aggarwal, 2000, The Journal of Immunology.

Targeting inflammation-induced obesity and metabolic diseases by curcumin and other nutraceuticals.

B. Aggarwal, 2010, Annual review of nutrition.

Curcumin: Getting Back to the Roots

B. Aggarwal, G. Sethi, S. Shishodia, 2005, Annals of the New York Academy of Sciences.

Curcumin (diferuloylmethane) induces apoptosis through activation of caspase-8, BID cleavage and cytochrome c release: its suppression by ectopic expression of Bcl-2 and Bcl-xl.

B. Aggarwal, A. Mukhopadhyay, R. J. Anto, 2002, Carcinogenesis.

Targeting Inflammatory Pathways by Triterpenoids for Prevention and Treatment of Cancer

B. Aggarwal, R. Kannappan, S. Prasad, 2010, Toxins.

Recombinant proteins and genomics in cancer therapy

B. Aggarwal, K. Gohil, B. Ozpolat, 2009 .

Bisdemethylcurcumin and structurally related hispolon analogues of curcumin exhibit enhanced prooxidant, anti-proliferative and anti-inflammatory activities in vitro.

B. Aggarwal, B. Sung, Jayaraj Ravindran, 2010, Biochemical pharmacology.

Curcumin inhibits proliferation, invasion, angiogenesis and metastasis of different cancers through interaction with multiple cell signaling proteins.

B. Aggarwal, A. Kunnumakkara, P. Anand, 2008, Cancer letters.

Aldose Reductase Mediates Mitogenic Signaling in Vascular Smooth Muscle Cells*

B. Aggarwal, K. Ramana, S. Srivastava, 2002, The Journal of Biological Chemistry.

Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.

B. Aggarwal, S. Shishodia, 2004, The Journal of biological chemistry.

Role of nuclear factor-κB-mediated inflammatory pathways in cancer-related symptoms and their regulation by nutritional agents

B. Aggarwal, J. Kim, P. Dougherty, 2011, Experimental biology and medicine.

Role of curcumin in cancer therapy.

B. Aggarwal, S. Shishodia, M. Chaturvedi, 2007, Current problems in cancer.

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX‐2, MMP‐9, VEGF and CXCR4 expression in an orthotopic mouse model

B. Aggarwal, K. Harikumar, A. Kunnumakkara, 2009, International journal of cancer.

Curcumin down regulates smokeless tobacco-induced NF-kappaB activation and COX-2 expression in human oral premalignant and cancer cells.

B. Aggarwal, S. Shishodia, R. Ralhan, 2006, Toxicology.

Embelin, an Inhibitor of X Chromosome-Linked Inhibitor-of-Apoptosis Protein, Blocks Nuclear Factor-κB (NF-κB) Signaling Pathway Leading to Suppression of NF-κB-Regulated Antiapoptotic and Metastatic Gene Products

B. Aggarwal, G. Sethi, K. Ahn, 2007, Molecular Pharmacology.

Curcumin, a component of turmeric: From farm to pharmacy

B. Aggarwal, Subash C. Gupta, G. Kismali, 2013, BioFactors.

Boswellic acid exerts antitumor effects in colorectal cancer cells by modulating expression of the let-7 and miR-200 microRNA family.

B. Aggarwal, B. Sung, A. Goel, 2012, Carcinogenesis.

Acetyl‐11‐keto‐β‐boswellic acid suppresses invasion of pancreatic cancer cells through the downregulation of CXCR4 chemokine receptor expression

Mingyao Liu, B. Aggarwal, Byoungduck Park, 2011, International journal of cancer.

Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.

Mingyao Liu, Xiufeng Pang, Z. Yi, 2009, Cancer research.

Phase II Trial of Curcumin in Patients with Advanced Pancreatic Cancer

Razelle Kurzrock, Bharat B. Aggarwal, Chaan S. Ng, 2008, Clinical Cancer Research.

Turmeric, the golden spice: From traditional medicine to modern medicine

Sahdeo Prasad, Bharat B. Aggarwal, B. Aggarwal, 2011 .

Molecular Targets and Therapeutic Uses of Spices: Modern Uses for Ancient Medicine

Bharat B. Aggarwal, Ajaikumar B. Kunnumakkara, B. Aggarwal, 2009 .

Receptor-Mediated Choreography of Life and Death

B. Aggarwal, A. Bhardwaj, 2003, Journal of Clinical Immunology.

Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Fabrication and Characterization of Silk Fibroin-derived Curcumin Nanoparticles for Cancer Therapy

A. Mathur, B. Aggarwal, Vishal K. Gupta, 2022 .

Curcumin Inhibits Tumor Growth and Angiogenesis in Ovarian Carcinoma by Targeting the Nuclear Factor-κB Pathway

Liz Y. Han, B. Aggarwal, A. Sood, 2007, Clinical Cancer Research.

Inflammation, NF-κB, and Chronic Diseases: How are They Linked?

B. Aggarwal, A. Kunnumakkara, K. Thakur, 2020, Critical reviews in immunology.

Overexpression of γ-glutamylcysteine synthetase suppresses tumor necrosis factor-induced apoptosis and activation of nuclear transcription factor-kappa B and activator protein-1

S. Manna, B. Aggarwal, M. Kuo, 1999, Oncogene.

Plasma clearance and tissue uptake of native and desialylated equine gonadotropins

B. Aggarwal, H. Papkoff, B. B. Aggarwal, 1985 .

Biological and binding activities of equine pituitary gonadotrophins and pregnant mare serum gonadotrophin.

B. Aggarwal, P. Licht, S. Farmer, 1979, The Journal of endocrinology.

Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention

K. Griffiths, H. Buttar, B. Aggarwal, 2016, Diseases.

Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals

B. Aggarwal, J. Kim, S. Prasad, 2010, Cancer and Metastasis Reviews.

Targeting Cell Survival Proteins for Cancer Cell Death

B. Aggarwal, S. Amin, S. Prasad, 2016, Pharmaceuticals.

Inflammation, a Double-Edge Sword for Cancer and Other Age-Related Diseases

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2018, Front. Immunol..

Curcumin, the Golden Spice From Indian Saffron, Is a Chemosensitizer and Radiosensitizer for Tumors and Chemoprotector and Radioprotector for Normal Organs

Bharat B. Aggarwal, Ajay Goel, B. Aggarwal, 2010, Nutrition and cancer.

Activation of Transcription Factor NF-κB Is Suppressed by Curcumin (Diferuloylmethane) (*)

B. Aggarwal, Sanjaya Singh, 1995, The Journal of Biological Chemistry.

Activation of transcription factor NF-kappa B is suppressed by curcumin (diferuloylmethane) [corrected].

B. Aggarwal, S. Singh, 1995, The Journal of biological chemistry.

Multi-targeted therapy by curcumin: how spicy is it?

Ajay Goel, B. Aggarwal, A. Goel, 2008, Molecular nutrition & food research.

NF-κB addiction and its role in cancer: ‘one size does not fit all’

B. Aggarwal, R. Kannappan, B. Sung, 2011, Oncogene.

Gossypol Induces Death Receptor-5 through Activation of the ROS-ERK-CHOP Pathway and Sensitizes Colon Cancer Cells to TRAIL*

B. Aggarwal, S. Prasad, B. Sung, 2010, The Journal of Biological Chemistry.

Gambogic acid, a novel ligand for transferrin receptor, potentiates TNF-induced apoptosis through modulation of the nuclear factor-kappaB signaling pathway.

B. Aggarwal, K. Ahn, B. Sung, 2007, Blood.

γ-Tocotrienol induces growth arrest through a novel pathway with TGFβ2 in prostate cancer.

B. Aggarwal, R. Newman, Peiying Yang, 2011, Free radical biology & medicine.

Relationship of sialic acid residues to in vitro biological and immunological activities of equine gonadotropins.

B. Aggarwal, H. Papkoff, 1981, Biology of reproduction.

Subunits of an avian (ostrich) follicle-stimulating hormone and their hybridization with subunits of mammalian gonadotropins.

B. Aggarwal, P. Licht, H. Papkoff, 1983, General and comparative endocrinology.

Role of pro-oxidants and antioxidants in the anti-inflammatory and apoptotic effects of curcumin (diferuloylmethane).

B. Aggarwal, G. Sethi, B. Sung, 2007, Free radical biology & medicine.

Pathways Linked to Cancer Chemoresistance and Their Targeting by Nutraceuticals

B. Aggarwal, Sukhmahendra Singh, A. Bharti, 2018 .

Resveratrol: A multitargeted agent for age-associated chronic diseases

B. Aggarwal, K. Harikumar, 2008, Cell cycle.

Calagualine inhibits nuclear transcription factors-kappaB activated by various inflammatory and tumor promoting agents.

S. Manna, B. Aggarwal, C. Bueso-Ramos, 2003, Cancer letters.

Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy

B. Aggarwal, G. Sethi, A. Nair, 2006 .

Methotrexate Suppresses NF-κB Activation Through Inhibition of IκBα Phosphorylation and Degradation1

B. Aggarwal, S. Majumdar, 2001, The Journal of Immunology.

Expert opinion : food for thought Back to basics : how natural products can provide the basis for new therapeutics

B. Aggarwal, G. Sethi, Sunil Krishnan, 2007 .

Effect of visible light on the mitochondrial inner membrane.

B. Aggarwal, L. Packer, Y. Avi-Dor, 1976, Biochemical and biophysical research communications.

Studies on the disappearance of equine chorionic gonadotropin from the circulation in the rat: tissue uptake and degradation.

B. Aggarwal, H. Papkoff, 1981, Endocrinology.

Interaction of equine luteinizing hormone with binding sites for follicle-stimulating hormone in the rat seminiferous tubule.

B. Aggarwal, H. Papkoff, A. Bona‐Gallo, 1980, Endocrinology.

Role of Cytokines and Proto‐oncogenes in Sperm Cell Function: Relevance to Immunologic Infertility

B. Aggarwal, M. Chaturvedi, R. Naz, 1994, American journal of reproductive immunology.

Characterization of the in vitro and in vivo species preference of human and murine tumor necrosis factor-alpha.

B. Aggarwal, I. Figari, M. Palladino, 1988, Cancer research.

Probiotic Lactobacillus reuteri promotes TNF‐induced apoptosis in human myeloid leukemia‐derived cells by modulation of NF‐κB and MAPK signalling

B. Aggarwal, G. Sethi, J. Versalovic, 2008, Cellular microbiology.

Purification and characterization of donkey chorionic gonadotrophin.

B. Aggarwal, S. Farmer, W. Allen, 1980, The Journal of endocrinology.

Curcumin (diferuloylmethane) inhibits constitutive NF-kappaB activation, induces G1/S arrest, suppresses proliferation, and induces apoptosis in mantle cell lymphoma.

B. Aggarwal, S. Shishodia, R. Lai, 2005, Biochemical pharmacology.

Effect of the alpha subunit of equine LH on the FSH induced cAMP production in rat seminiferous tubule cells.

B. Aggarwal, P. Licht, H. Papkoff, 1981, Endocrinology.

Overexpression of Manganese Superoxide Dismutase Suppresses Tumor Necrosis Factor-induced Apoptosis and Activation of Nuclear Transcription Factor-κB and Activated Protein-1*

Tao Yan, Bharat B. Aggarwal, S. Manna, 1998, The Journal of Biological Chemistry.

Role of genitourinary inflammation in infertility: synergistic effect of lipopolysaccharide and interferon-gamma on human spermatozoa.

B. Aggarwal, S. Sikka, T. Bivalacqua, 2001, International journal of andrology.

Xanthohumol, a prenylated chalcone derived from hops, suppresses cancer cell invasion through inhibiting the expression of CXCR4 chemokine receptor.

B. Aggarwal, Y. Wang, Y. Chen, 2012, Current molecular medicine.

The past, present and future of multi-targeted cancer treatment "naturally": food for thought.

B. Aggarwal, 2008, Cancer letters.

Genetic Deletion of NAD(P)H:Quinone Oxidoreductase 1 Abrogates Activation of Nuclear Factor-κB, IκBα Kinase, c-Jun N-terminal Kinase, Akt, p38, and p44/42 Mitogen-activated Protein Kinases and Potentiates Apoptosis*

Bharat B. Aggarwal, Anil K. Jaiswal, Gautam Sethi, 2006, Journal of Biological Chemistry.

Genetic deletion of NAD(P)H:quinone oxidoreductase 1 abrogates activation of nuclear factor-kappaB, IkappaBalpha kinase, c-Jun N-terminal kinase, Akt, p38, and p44/42 mitogen-activated protein kinases and potentiates apoptosis.

Gautam Sethi, B. Aggarwal, G. Sethi, 2006, The Journal of biological chemistry.

Experimental Biology and Medicine

Bharat B. Aggarwal, Gautam Sethi, B. Aggarwal, 2007 .

Ursolic Acid Inhibits STAT3 Activation Pathway Leading to Suppression of Proliferation and Chemosensitization of Human Multiple Myeloma Cells

B. Aggarwal, G. Sethi, K. Ahn, 2007, Molecular Cancer Research.

Human Chorionic Gonadotropin Suppresses Activation of Nuclear Transcription Factor-κB and Activator Protein-1 Induced by Tumor Necrosis Factor*

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of Biological Chemistry.

Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor.

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of biological chemistry.

Purification and characterization of the gonadotropin secreted by cultured horse trophoblast cells.

B. Aggarwal, S. Farmer, H Papkoff, 1980, Endocrinology.

Guggulsterone Inhibits NF-κB and IκBα Kinase Activation, Suppresses Expression of Anti-apoptotic Gene Products, and Enhances Apoptosis*

B. Aggarwal, S. Shishodia, 2004, Journal of Biological Chemistry.

The guggul for chronic diseases: ancient medicine, modern targets.

B. Aggarwal, S. Shishodia, K. Harikumar, 2008, Anticancer research.

Ectopic Expression of Hepatitis C Virus Core Protein Differentially Regulates Nuclear Transcription Factors

S. Manna, B. Aggarwal, R. Ray, 1998, Journal of Virology.

Inhibition of Tumor Necrosis Factor (TNF-α)-mediated Apoptosis by Hepatitis C Virus Core Protein*

B. Aggarwal, K. Meyer, R. Ray, 1998, The Journal of Biological Chemistry.

Tumor necrosis factors: gene structure and biological activities.

D. Goeddel, B. Aggarwal, H. Shepard, 1986, Cold Spring Harbor symposia on quantitative biology.

Chemosensitization and radiosensitization of tumors by plant polyphenols.

A. Garg, T. Buchholz, B. Aggarwal, 2005, Antioxidants & redox signaling.

Leflunomide Suppresses TNF-Induced Cellular Responses: Effects on NF-κB, Activator Protein-1, c-Jun N-Terminal Protein Kinase, and Apoptosis1

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of Immunology.

Guggulsterone inhibits tumor cell proliferation, induces S-phase arrest, and promotes apoptosis through activation of c-Jun N-terminal kinase, suppression of Akt pathway, and downregulation of antiapoptotic gene products.

B. Aggarwal, G. Sethi, S. Shishodia, 2007, Biochemical pharmacology.

Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1.

B. Aggarwal, G. Sethi, K. Ahn, 2008, Cancer research.

Synthesis, Characterization and In Vitro Anticancer Activity of C-5 Curcumin Analogues with Potential to Inhibit TNF-α-Induced NF-κB Activation

B. Aggarwal, A. Tyagi, D. Rawat, 2014, BioMed research international.

Triple helix-forming oligodeoxyribonucleotides targeted to the human tumor necrosis factor (TNF) gene inhibit TNF production and block the TNF-dependent growth of human glioblastoma tumor cells.

B. Aggarwal, M. Hogan, R. Rando, 1996, Cancer research.

Antiproliferative Effects of IFN-α Correlate with the Downregulation of Nuclear Factor-κB in Human Burkitt Lymphoma Daudi Cells

B. Aggarwal, P. Rath, 2001 .

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

S. Manna, B. Aggarwal, A. Mukhopadhyay, 1999, Journal of immunology.

TNF: a master switch for inflammation to cancer.

B. Aggarwal, G. Sethi, B. Sung, 2008, Frontiers in bioscience : a journal and virtual library.

Transfection of cells with basic fibroblast growth factor and Kaposi fibroblast growth factor genes induce resistance to and receptor modulation of tumor necrosis factor

B. Aggarwal, K. Totpal, É. Pócsik, 1995, FEBS letters.

Cytokines: from clone to clinic.

Bharat B. Aggarwal, B. Aggarwal, É. Pócsik, 1992, Archives of biochemistry and biophysics.

Targeting Inflammatory Pathways by Flavonoids for Prevention and Treatment of Cancer

B. Aggarwal, S. Prasad, M. Chaturvedi, 2010, Planta medica.

Honokiol Potentiates Apoptosis, Suppresses Osteoclastogenesis, and Inhibits Invasion through Modulation of Nuclear Factor-κB Activation Pathway

B. Aggarwal, G. Sethi, J. Arbiser, 2006, Molecular Cancer Research.

Identification of a novel blocker of IκBα kinase activation that enhances apoptosis and inhibits proliferation and invasion by suppressing nuclear factor-κB

B. Aggarwal, B. Sung, M. Chaturvedi, 2008, Molecular Cancer Therapeutics.

Nuclear factor-κ B : The enemy within

B. Aggarwal, 2004 .

1'-Acetoxychavicol acetate suppresses angiogenesis-mediated human prostate tumor growth by targeting VEGF-mediated Src-FAK-Rho GTPase-signaling pathway.

Mingyao Liu, Xiufeng Pang, Z. Yi, 2011, Carcinogenesis.

Evolution of Innate and Adaptive Immunity

B. Aggarwal, D. Heber, 2014 .

Identification of human uromodulin as the Tamm-Horsfall urinary glycoprotein.

E. Chen, D. Goeddel, W. Kohr, 1987, Science.

Curcumin decreases cholangiocarcinogenesis in hamsters by suppressing inflammation‐mediated molecular events related to multistep carcinogenesis

B. Aggarwal, C. Pairojkul, Y. Hiraku, 2011, International journal of cancer.

Role of chemopreventive agents in cancer therapy.

B. Aggarwal, T. Dorai, 2004, Cancer letters.

Resveratrol Chemosensitizes TNF-β-Induced Survival of 5-FU-Treated Colorectal Cancer Cells

M. Shakibaei, B. Aggarwal, A. Goel, 2018, Nutrients.

Regulation of TRAIL-induced apoptosis by ectopic expression of antiapoptotic factors.

B. Aggarwal, Y. Takada, Uddalak Bhardwaj, 2004, Vitamins and hormones.

Natural Agents That Can Sensitize Tumor Cells to Chemotherapy and Radiation Therapy

B. Aggarwal, G. Jagetia, Sunil Krishnan, 2008 .

Tocotrienols, inflammation, and cancer: How are they linked?

B. Aggarwal, S. Prasad, Subash C. Gupta, 2012 .

Cancer and diet: How are they related?

B. Aggarwal, S. Prasad, B. Sung, 2011, Free radical research.

PTEN enhances TNF-induced apoptosis through modulation of nuclear factor-kappaB signaling pathway in human glioma cells.

B. Aggarwal, W. Yung, Y. Takada, 2006, Biochemical and biophysical research communications.

Human tumor necrosis factor. Production, purification, and characterization.

D. Goeddel, W. Kohr, B. Aggarwal, 1985, The Journal of biological chemistry.

Genome-Based Multi-targeting of Cancer: Hype or Hope?

B. Aggarwal, Lixing Yang, S. Prasad, 2015 .

Progress in Chemoprevention Drug Development: The Promise of Molecular Biomarkers for Prevention of Intraepithelial Neoplasia and Cancer—A Plan to Move Forward

G. Mills, S. Lam, M. Spitz, 2006, Clinical Cancer Research.

Antitumor activity of the novel human breast cancer growth inhibitor, mammary-derived growth inhibitor-related gene, MRG.

B. Aggarwal, J. Ni, R. Gentz, 1997, Cancer research.

B κ invasion by suppressing nuclear factor-that enhances apoptosis and inhibits proliferation and kinase activation α B κ Identification of a novel blocker of I Updated

B. Aggarwal, B. Sung, M. Chaturvedi, 2008 .

Curcumin Sensitizes Human Colorectal Cancer Xenografts in Nude Mice to γ-Radiation by Targeting Nuclear Factor-κB–Regulated Gene Products

B. Aggarwal, A. Kunnumakkara, S. Guha, 2008, Clinical Cancer Research.

Glioma cells deficient in urokinase plaminogen activator receptor expression are susceptible to tumor necrosis factor-alpha-related apoptosis-inducing ligand-induced apoptosis.

G. Kouraklis, B. Aggarwal, D. Dinh, 2001, Clinical cancer research : an official journal of the American Association for Cancer Research.

Constitutive activation of NF-kappaB causes resistance to apoptosis in human cutaneous T cell lymphoma HuT-78 cells. Autocrine role of tumor necrosis factor and reactive oxygen intermediates.

B. Aggarwal, D. Giri, 1998, The Journal of biological chemistry.

Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor

Mingyao Liu, B. Aggarwal, R. Kannappan, 2010, Journal of Molecular Medicine.

Celastrol, a Triterpene, Enhances TRAIL-induced Apoptosis through the Down-regulation of Cell Survival Proteins and Up-regulation of Death Receptors*

B. Aggarwal, Byoungduck Park, B. Sung, 2010, The Journal of Biological Chemistry.

Cloning and expression of cDNA for human lymphotoxin, a lymphokine with tumour necrosis activity

B. Aggarwal, M. Palladino, T. Bringman, 1984, Nature.

Tumor necrosis factors: developments during the last decade.

B. Aggarwal, B B Aggarwal, K. Natarajan, 1996, European cytokine network.

Identification of a p65 Peptide That Selectively Inhibits NF-κ B Activation Induced by Various Inflammatory Stimuli and Its Role in Down-regulation of NF-κB-mediated Gene Expression and Up-regulation of Apoptosis*

Sujay K. Singh, B. Aggarwal, Y. Takada, 2004, Journal of Biological Chemistry.

Interferon-gamma induces cell surface expression for both types of tumor necrosis factor receptors.

B. Aggarwal, R. Pandita, É. Pócsik, 1992, FEBS letters.

γ-Tocotrienol suppresses growth and sensitises human colorectal tumours to capecitabine in a nude mouse xenograft model by down-regulating multiple molecules

B. Aggarwal, S. Prasad, Subash C. Gupta, 2016, British Journal of Cancer.

Tocotrienols fight cancer by targeting multiple cell signaling pathways

B. Aggarwal, J. Kim, R. Kannappan, 2011, Genes & Nutrition.

Tumour necrosis factors receptor associated signalling molecules and their role in activation of apoptosis, JNK and NF-κB

B. Aggarwal, B B Aggarwal, 2000, Annals of the rheumatic diseases.

Signal transduction by tumour necrosis factor and tumour necrosis factor related ligands and their receptors

B. Aggarwal, B. Darnay, Bryant G Darnay, 1999, Annals of the rheumatic diseases.

Identification and functional characterization of DR6, a novel death domain‐containing TNF receptor

B. Aggarwal, V. Dixit, Guo-liang Yu, 1998, FEBS letters.

Death domain receptors and their role in cell demise.

B. Aggarwal, J. Ni, A. Singh, 1998, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Overexpression of the p80 TNF receptor leads to TNF-dependent apoptosis, nuclear factor-kappa B activation, and c-Jun kinase activation.

R. Heller, B. Aggarwal, R. Heller, 1998, Journal of immunology.

Early events in TNF signaling: a story of associations and dissociations

B. Aggarwal, B. Darnay, 1997, Journal of leukocyte biology.

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2017, Clinical science.

Morin inhibits STAT3 tyrosine 705 phosphorylation in tumor cells through activation of protein tyrosine phosphatase SHP1.

B. Aggarwal, Subash C. Gupta, Kanokkarn Phromnoi, 2013, Biochemical pharmacology.

Capsaicin Is a Novel Blocker of Constitutive and Interleukin-6–Inducible STAT3 Activation

B. Aggarwal, G. Sethi, A. Kunnumakkara, 2007, Clinical Cancer Research.

Targeting Signal‐Transducer‐and‐Activator‐of‐Transcription‐3 for Prevention and Therapy of Cancer

B. Aggarwal, G. Sethi, K. Ahn, 2006, Annals of the New York Academy of Sciences.

Targeting constitutive and interleukin‐6‐inducible signal transducers and activators of transcription 3 pathway in head and neck squamous cell carcinoma cells by curcumin (diferuloylmethane)

B. Aggarwal, J. Myers, N. Chakravarti, 2006, International journal of cancer.

Capsaicin induces G1/S cell cycle arrest leading to apoptosis of multiple myeloma cells through suppression of STAT3 activation and STAT3-regulated gene products.

B. Aggarwal, G. Sethi, M. Bhutani, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor‐κB signaling

Sujay K. Singh, B. Aggarwal, J. Myers, 2004 .

Curcumin (Diferuloylmethane) Downregulates the Constitutive Activation of Nuclear Factor κB and IκBα Kinase in Human Multiple Myeloma Cells Leading to Suppression of Proliferation and Induction of Apoptosis

Sujay K. Singh, B. Aggarwal, N. Donato, 2002 .

Curcumin potentiates the antitumor effects of gemcitabine in an orthotopic model of human bladder cancer through suppression of proliferative and angiogenic biomarkers.

B. Aggarwal, B. Sung, A. Kamat, 2010, Biochemical pharmacology.

Curcumin potentiates the antitumor effects of Bacillus Calmette-Guerin against bladder cancer through the downregulation of NF-kappaB and upregulation of TRAIL receptors.

B. Aggarwal, B. Sung, A. Kamat, 2009, Cancer research.

Curcumin (Diferuloylmethane) Down-Regulates Expression of Cell Proliferation and Antiapoptotic and Metastatic Gene Products through Suppression of IκBα Kinase and Akt Activation

B. Aggarwal, S. Shishodia, Y. Takada, 2006, Molecular Pharmacology.

Aeromonas hydrophila Cytotoxic Enterotoxin Activates Mitogen-activated Protein Kinases and Induces Apoptosis in Murine Macrophages and Human Intestinal Epithelial Cells*

B. Aggarwal, J. Sha, I. Boldogh, 2004, Journal of Biological Chemistry.

Redox regulation of apoptosis by members of the TNF superfamily.

G. Schulze-Tanzil, M. Shakibaei, B. Aggarwal, 2005, Antioxidants & redox signaling.

Recombinant Organisms as Source of Cancer Biotherapeutics

B. Aggarwal, K. Mehta, 1998 .

Lymphotoxin: Developments during the last decade

B. Aggarwal, Sanjaya Singh, 1997 .

Qualitative and quantitative differences in the cellular responses mediated through Fas antigen and tumor necrosis factor receptor.

B. Aggarwal, R. Lapushin, K. Totpal, 1996, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Evidence that TNF-TNFR1-TRADD-TRAF2-RIP-TAK1-IKK pathway mediates constitutive NF-κB activation and proliferation in human head and neck squamous cell carcinoma

B. Aggarwal, J. Myers, Y. Takada, 2007, Oncogene.

K-Ras Promotes Angiogenesis Mediated by Immortalized Human Pancreatic Epithelial Cells through Mitogen-Activated Protein Kinase Signaling Pathways

P. M. Campbell, C. Der, B. Aggarwal, 2009, Molecular Cancer Research.

Resveratrol blocks interleukin-1beta-induced activation of the nuclear transcription factor NF-kappaB, inhibits proliferation, causes S-phase arrest, and induces apoptosis of acute myeloid leukemia cells.

Z. Estrov, D. Harris, B. Aggarwal, 2003, Blood.

Evidence That Tumor Microenvironment Initiates Epithelial-To-Mesenchymal Transition and Calebin A can Suppress it in Colorectal Cancer Cells

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2021, Frontiers in Pharmacology.

3-Formylchromone Interacts with Cysteine 38 in p65 Protein and with Cysteine 179 in IκBα Kinase, Leading to Down-regulation of Nuclear Factor-κB (NF-κB)-regulated Gene Products and Sensitization of Tumor Cells*

Sharangdhar S. Phatak, B. Aggarwal, Shuxing Zhang, 2011, The Journal of Biological Chemistry.

The rGel/BLyS fusion toxin inhibits diffuse large B-cell lymphoma growth in vitro and in vivo.

R. Aguiar, B. Aggarwal, K. Ahn, 2010, Neoplasia.

Nuclear Factor-κB Activation: From Bench to Bedside

B. Aggarwal, G. Sethi, B. Sung, 2008 .

Genetic deletion of PKR abrogates TNF-induced activation of IκBα kinase, JNK, Akt and cell proliferation but potentiates p44/p42 MAPK and p38 MAPK activation

S. Swisher, B. Aggarwal, Y. Takada, 2007, Oncogene.

Simvastatin Potentiates TNF-α-Induced Apoptosis through the Down-Regulation of NF-κB-Dependent Antiapoptotic Gene Products: Role of IκBα Kinase and TGF-β-Activated Kinase-11

Bharat B. Aggarwal, Gautam Sethi, B. Aggarwal, 2007, The Journal of Immunology.

γ-Tocotrienol Inhibits Nuclear Factor-κB Signaling Pathway through Inhibition of Receptor-interacting Protein and TAK1 Leading to Suppression of Antiapoptotic Gene Products and Potentiation of Apoptosis*

B. Aggarwal, G. Sethi, K. Ahn, 2007, Journal of Biological Chemistry.

apoptosis through modulation of the nuclear factor-κB signaling pathway

B. Aggarwal, K. Ahn, B. Sung, 2007 .

Activated Kinase-1 β Kinase and TGF-α B κ Products : Role of I B-Dependent Antiapoptotic Gene κ NF-Apoptosis through the Down-Regulation of-Induced α Simvastatin Potentiates TNF -

B. Aggarwal, G. Sethi, K. Ahn, 2007 .

Isodeoxyelephantopin, a Novel Sesquiterpene Lactone, Potentiates Apoptosis, Inhibits Invasion, and Abolishes Osteoclastogenesis through Suppression of Nuclear Factor-κB (NF-κB) Activation and NF-κB-Regulated Gene Expression

B. Aggarwal, Y. Takada, O. Oommen, 2006, Clinical Cancer Research.

Indirubin Enhances Tumor Necrosis Factor-induced Apoptosis through Modulation of Nuclear Factor-κB Signaling Pathway*

B. Aggarwal, G. Sethi, K. Ahn, 2006, Journal of Biological Chemistry.

Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, IκB kinase activation and NF-κB-regulated gene expression

B. Aggarwal, S. Shishodia, B B Aggarwal, 2006, Oncogene.

Cells : Delineation of a Novel Pathway B in Cancer κ Constitutive Activation of Nuclear Factor-Overexpression of Tissue Transglutaminase Leads to Updated

B. Aggarwal, G. Sethi, Huamin Wang, 2006 .

Indole-3-carbinol suppresses NF-κB and IκBα kinase activation, causing inhibition of expression of NF-κB-regulated antiapoptotic and metastatic gene products and enhancement of apoptosis in myeloid and leukemia cells

M. Andreeff, B. Aggarwal, Y. Takada, 2005 .

Identification of a Novel Blocker of IκBα Kinase That Enhances Cellular Apoptosis and Inhibits Cellular Invasion through Suppression of NF-κB-Regulated Gene Products1

B. Aggarwal, Y. Takada, A. Murakami, 2005, The Journal of Immunology.

Evodiamine Abolishes Constitutive and Inducible NF-κB Activation by Inhibiting IκBα Kinase Activation, Thereby Suppressing NF-κB-regulated Antiapoptotic and Metastatic Gene Expression, Up-regulating Apoptosis, and Inhibiting Invasion*

B. Aggarwal, Y. Takada, Yoshinori Kobayashi, 2005, Journal of Biological Chemistry.

Suppression of NF-and Inhibits Cellular Invasion through Kinase That Enhances Cellular Apoptosis α B κ Identification of a Novel Blocker of

B. Aggarwal, Y. Takada, A. Murakami, 2005 .

Pro-apototic and anti-apoptotic effects of tumor necrosis factor in tumor cells. Role of nuclear transcription factor NF-kappaB.

B. Aggarwal, Y. Takada, 2005, Cancer treatment and research.

Nuclear factor-kappaB: a friend or a foe in cancer?

B. Aggarwal, S. Shishodia, 2004, Biochemical pharmacology.

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates TNF-Induced NF-κB Activation through Inhibition of Activation of IκBα Kinase and Akt in Human Non-Small Cell Lung Carcinoma: Correlation with Suppression of COX-2 Synthesis1

B. Aggarwal, S. Shishodia, D. Koul, 2004, The Journal of Immunology.

Cyclooxygenase (COX)-2 Inhibitor Celecoxib Abrogates Activation of Cigarette Smoke-Induced Nuclear Factor (NF)-κB by Suppressing Activation of I-κB α Kinase in Human Non-Small Cell Lung Carcinoma

B. Aggarwal, S. Shishodia, 2004, Cancer Research.

Cyclooxygenase (COX)-2 inhibitor celecoxib abrogates activation of cigarette smoke-induced nuclear factor (NF)-kappaB by suppressing activation of IkappaBalpha kinase in human non-small cell lung carcinoma: correlation with suppression of cyclin D1, COX-2, and matrix metalloproteinase-9.

B. Aggarwal, S. Shishodia, 2004, Cancer research.

Genetic Deletion of Glycogen Synthase Kinase-3β Abrogates Activation of IκBα Kinase, JNK, Akt, and p44/p42 MAPK but Potentiates Apoptosis Induced by Tumor Necrosis Factor*

B. Aggarwal, Y. Takada, X. Fang, 2004, Journal of Biological Chemistry.

Protein Farnesyltransferase Inhibitor (SCH 66336) Abolishes NF-κB Activation Induced by Various Carcinogens and Inflammatory Stimuli Leading to Suppression of NF-κB-regulated Gene Expression and Up-regulation of Apoptosis*

F. Khuri, B. Aggarwal, Y. Takada, 2004, Journal of Biological Chemistry.

Nuclear transcription factor NF-kappa B: role in biology and medicine.

B. Aggarwal, S. Shishodia, Ashok Kumar, 2004, Indian journal of experimental biology.

Suppression of COX-2 Synthesis Lung Carcinoma : Correlation with Kinase and Akt in Human Non-Small Cell α B κ through Inhibition of Activation of I B Activation κ Abrogates TNF-Induced NF-Cyclooxygenase ( COX )-2 Inhibitor Celecoxib

B. Aggarwal, S. Shishodia, D. Koul, 2004 .

Curcumin (diferuloylmethane) down-regulates cigarette smoke-induced NF-κB activation through inhibition of IκBα kinase in human lung epithelial cells: correlation with suppression of COX-2, MMP-9 and cyclin D1

B. Aggarwal, S. Shishodia, C. Gairola, 2003 .

Metalloproteinase 9 , and Cyclin D 1 Down-Regulation of Cyclooxygenase 2 , Matrix Kinase and p 65 Phosphorylation : Correlation with α B κ by Carcinogenic Agents through Suppression of I B Activation Induced κ Ursolic Acid Inhibits Nuclear Factor-Updated

Sanjeev Banerjee, B. Aggarwal, S. Shishodia, 2003 .

Nuclear Factor-κB Activation: A Question of Life or Death

Bharat B. Aggarwal, Shishir Shishodia, B. Aggarwal, 2002 .

Lymphotoxin is an autocrine growth factor for Epstein-Barr virus- infected B cell lines

Z. Estrov, D. Harris, B. Aggarwal, 1993, The Journal of experimental medicine.

Recent developments in the chemistry and biology of human lymphotoxin

B. Aggarwal, 1985 .

[33] Human lymphotoxin

B. Aggarwal, 1985 .

Chemical and Biological Properties of Human Lymphotoxin

B. Aggarwal, R. Harkins, B. Moffat, 1984 .

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-κB and nuclear factor-κB–regulated gene products in IFN-α–sensitive and IFN-α–resistant human bladder cancer cells

B. Aggarwal, G. Sethi, A. Kamat, 2007, Molecular Cancer Therapeutics.

HIV-Tat protein activates c-Jun N-terminal kinase and activator protein-1.

S. Manna, B. Aggarwal, Anil Kumar, 1998, Journal of immunology.

Bcl-xL Suppresses TNF-Mediated Apoptosis and Activation of Nuclear Factor-κB, Activation Protein-1, and c-Jun N-Terminal Kinase

S. Manna, B. Aggarwal, V. Haridas, 2000 .

Regulation of cell signaling pathways by dietary agents for cancer prevention and treatment.

B. Aggarwal, Subash C. Gupta, M. Pandey, 2017, Seminars in cancer biology.

Necrosis and Glioblastoma: A Friend or a Foe? A Review and a Hypothesis

Raymond Sawaya, G. Fuller, B. Aggarwal, 2002, Neurosurgery.

Cellular Mechanisms of Cytokine Activation

B. Aggarwal, D. Heber, 2014 .

The role of TNF and its family members in inflammation and cancer: lessons from gene deletion.

Shishir Shishodia, B. Aggarwal, S. Shishodia, 2002, Current drug targets. Inflammation and allergy.

Mcl-1 Inhibition: Managing Malignancy in Multiple Myeloma

B. Aggarwal, M. Pandey, Robert Chitren, 2021, Frontiers in Pharmacology.

The rGel/BLyS fusion toxin inhibits STAT3 signaling via down-regulation of interleukin-6 receptor in diffuse large B-cell lymphoma.

R. Aguiar, B. Aggarwal, B. Sung, 2010, Biochemical pharmacology.

Association of activated transcription factor nuclear factor kappab with chemoradiation resistance and poor outcome in esophageal carcinoma.

J. Ajani, S. Swisher, Tsung-Teh Wu, 2006, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Exogenous Nef Protein Activates NF-κB, AP-1, and c-Jun N-Terminal Kinase and Stimulates HIV Transcription in Promonocytic Cells

Bharat B. Aggarwal, C. Van Lint, S. Manna, 2003, The Journal of Biological Chemistry.

Photo-oxidative Stress Down-modulates the Activity of Nuclear Factor-κB via Involvement of Caspase-1, Leading to Apoptosis of Photoreceptor Cells*

Bharat B. Aggarwal, B. Aggarwal, M. Al-Ubaidi, 1999, The Journal of Biological Chemistry.

Ectopic expression of Bcl-2 and Bcl-xL inhibits apoptosis induced by TNF-related apoptosis-inducing ligand (TRAIL) through suppression of caspases-8, 7, and 3 and BID cleavage in human acute myelogenous leukemia cell line HL-60.

B. Aggarwal, B. Lamothe, 2002, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

Nuclear factor-kappaB activation: a question of life or death.

Shishir Shishodia, B. Aggarwal, S. Shishodia, 2002, Journal of biochemistry and molecular biology.

Molecular mechanisms in Barrett's metaplasia and its progression.

J. Ajani, M. Hung, B. Aggarwal, 2007, Seminars in oncology.

Resveratrol, a popular dietary supplement for human and animal health: Quantitative research literature analysis - a review

Hari Prasad Devkota, A. Sureda, V. Gupta, 2019 .

Boswellic Acid Blocks Signal Transducers and Activators of Transcription 3 Signaling, Proliferation, and Survival of Multiple Myeloma via the Protein Tyrosine Phosphatase SHP-1

B. Aggarwal, B. Sung, A. Kunnumakkara, 2009, Molecular Cancer Research.

Dihydroxypentamethoxyflavone Down-Regulates Constitutive and Inducible Signal Transducers and Activators of Transcription-3 through the Induction of Tyrosine Phosphatase SHP-1

B. Aggarwal, R. Kannappan, S. Prasad, 2011, Molecular Pharmacology.

Gambogic Acid Inhibits STAT3 Phosphorylation through Activation of Protein Tyrosine Phosphatase SHP-1: Potential Role in Proliferation and Apoptosis

B. Aggarwal, S. Prasad, M. Pandey, 2011, Cancer Prevention Research.

Betulinic acid suppresses STAT3 activation pathway through induction of protein tyrosine phosphatase SHP‐1 in human multiple myeloma cells

B. Aggarwal, B. Sung, M. Pandey, 2010, International journal of cancer.

Signal Transducer and Activator of Transcription‐3, Inflammation, and Cancer

B. Aggarwal, K. Harikumar, B. Sung, 2009, Annals of the New York Academy of Sciences.

Nuclear factor-kappa B links carcinogenic and chemopreventive agents.

B. Aggarwal, R. Ralhan, M. Pandey, 2009, Frontiers in bioscience.

Curcumin circumvents chemoresistance in vitro and potentiates the effect of thalidomide and bortezomib against human multiple myeloma in nude mice model (Molecular Cancer Therapeutics (2009) 8, (959-970))

B. Aggarwal, G. Sethi, B. Sung, 2009 .

Nuclear factor-kappa B: from clone to clinic.

Gautam Sethi, B. Aggarwal, G. Sethi, 2007, Current molecular medicine.

Butein, a tetrahydroxychalcone, suppresses cancer‐induced osteoclastogenesis through inhibition of receptor activator of nuclear factor‐kappaB ligand signaling

B. Aggarwal, Mingyao Liu, B. Sung, 2011, International journal of cancer.

Triptolide, histone acetyltransferase inhibitor, suppresses growth and chemosensitizes leukemic cells through inhibition of gene expression regulated by TNF-TNFR1-TRADD-TRAF2-NIK-TAK1-IKK pathway.

B. Aggarwal, Byoungduck Park, B. Sung, 2011, Biochemical pharmacology.

Fisetin, an Inhibitor of Cyclin-Dependent Kinase 6, Down-Regulates Nuclear Factor-κB-Regulated Cell Proliferation, Antiapoptotic and Metastatic Gene Products through the Suppression of TAK-1 and Receptor-Interacting Protein-Regulated IκBα Kinase Activation

B. Aggarwal, B. Sung, M. Pandey, 2007, Molecular Pharmacology.

Nuclear factor‐κB (nf‐κB) is frequently expressed in lung cancer and preneoplastic lesions

Bharat B. Aggarwal, Ignacio I. Wistuba, Shishir Shishodia, 2006 .

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

B. Aggarwal, H. Shepard, B. Sugarman, 1987, Cancer research.

Neutrophil gelatinase-associated lipocalin: a novel suppressor of invasion and angiogenesis in pancreatic cancer.

B. Aggarwal, Huamin Wang, K. Harikumar, 2008, Cancer research.

Modulation of Proteasome Pathways by Nutraceuticals

B. Aggarwal, S. Prasad, Subash C. Gupta, 2013 .

RKIP Sensitizes Prostate and Breast Cancer Cells to Drug-induced Apoptosis*

B. Aggarwal, J. Sedivy, P. Pantazis, 2004, Journal of Biological Chemistry.

Cancer drug discovery by repurposing: teaching new tricks to old dogs.

Sahdeo Prasad, Lauren J Webb, B. Aggarwal, 2013, Trends in pharmacological sciences.

Ursolic Acid Inhibits Growth and Metastasis of Human Colorectal Cancer in an Orthotopic Nude Mouse Model by Targeting Multiple Cell Signaling Pathways: Chemosensitization with Capecitabine

V. Baladandayuthapani, B. Aggarwal, Caimiao Wei, 2012, Clinical Cancer Research.

Pretherapy nuclear factor-κB status, chemoradiation resistance, and metastatic progression in esophageal carcinoma

J. Ajani, Tsung-Teh Wu, Z. Liao, 2006, Molecular Cancer Therapeutics.

Biochemical properties of equine chorionic gonadotrophin from two different pools of pregnant mare sera.

B. Aggarwal, S. Farmer, G. Seidel, 1980, Biology of reproduction.

Celastrol inhibits Tat-mediated human immunodeficiency virus (HIV) transcription and replication.

B. Aggarwal, K. S. Prabhu, V. Narayan, 2011, Journal of molecular biology.

Effect of tumour necrosis factor‐α (TNF‐α) and interferon‐γ (IFN‐γ) on human sperm motility, viability and motion parameters

B. Aggarwal, S. Sikka, H. Champion, 1997 .

Curcumin modulates the radiosensitivity of colorectal cancer cells by suppressing constitutive and inducible NF-kappaB activity.

Sushovan Guha, Sunil Krishnan, Shujun Shentu, 2009, International journal of radiation oncology, biology, physics.

Effect of tumour necrosis factor-alpha (TNF-alpha) and interferon-gamma (IFN-gamma) on human sperm motility, viability and motion parameters.

B. Aggarwal, M. Rajasekaran, R. Wang, 1997, International journal of andrology.

Curcumin: A component of the golden spice, targets multiple angiogenic pathways

B. Aggarwal, V. Yadav, 2011, Cancer biology & therapy.

Characterization of the antitumor activities of human tumor necrosis factor-alpha and the comparison with other cytokines: induction of tumor-specific immunity.

B. Aggarwal, A. Deleo, I. Figari, 1987, Journal of immunology.

Thalidomide Suppresses NF-κB Activation Induced by TNF and H2O2, But Not That Activated by Ceramide, Lipopolysaccharides, or Phorbol Ester1

B. Aggarwal, S. Majumdar, B. Lamothe, 2002, The Journal of Immunology.

Evidence that TNF-β induces proliferation in colorectal cancer cells and resveratrol can down-modulate it

M. Shakibaei, B. Aggarwal, A. Goel, 2019, Experimental biology and medicine.

Downregulation of tumor necrosis factor and other proinflammatory biomarkers by polyphenols.

B. Aggarwal, S. Prasad, Subash C. Gupta, 2014, Archives of biochemistry and biophysics.

Chronic Inflammation and Cancer: A Matter of Lifestyle

B. Aggarwal, S. Prasad, Subash C. Gupta, 2012 .

Flavopiridol Inhibits NF-κB Activation Induced by Various Carcinogens and Inflammatory Agents through Inhibition of IκBα Kinase and p65 Phosphorylation

B. Aggarwal, Y. Takada, 2004, Journal of Biological Chemistry.

Adenosine suppresses activation of nuclear factor-κB selectively induced by tumor necrosis factor in different cell types

B. Aggarwal, S. Majumdar, 2003, Oncogene.

Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells

B. Aggarwal, Dihua Yu, B. Sung, 2012, Breast Cancer Research.

Deguelin, an Akt Inhibitor, Suppresses IκBα Kinase Activation Leading to Suppression of NF-κB-Regulated Gene Expression, Potentiation of Apoptosis, and Inhibition of Cellular Invasion1

B. Aggarwal, G. Sethi, S. Shishodia, 2006, The Journal of Immunology.

Ursolic acid inhibits the growth of human pancreatic cancer and enhances the antitumor potential of gemcitabine in an orthotopic mouse model through suppression of the inflammatory microenvironment

B. Aggarwal, S. Prasad, Subash C. Gupta, 2016, Oncotarget.

Prevention and Treatment of Colorectal Cancer by Natural Agents from Mother Nature

B. Aggarwal, S. Prasad, B. Sung, 2013, Current Colorectal Cancer Reports.

Calebin A Potentiates the Effect of 5-FU and TNF-β (Lymphotoxin α) against Human Colorectal Cancer Cells: Potential Role of NF-κB †

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2020, International journal of molecular sciences.

Evidence That Calebin A, a Component of Curcuma Longa Suppresses NF-κB Mediated Proliferation, Invasion and Metastasis of Human Colorectal Cancer Induced by TNF-β (Lymphotoxin)

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2019, Nutrients.

Induction of the Epithelial-to-Mesenchymal Transition of Human Colorectal Cancer by Human TNF-β (Lymphotoxin) and its Reversal by Resveratrol

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2019, Nutrients.

Zyflamend suppresses growth and sensitizes human pancreatic tumors to gemcitabine in an orthotopic mouse model through modulation of multiple targets

B. Aggarwal, Z. Tong, B. Sung, 2012, International journal of cancer.

Silymarin suppresses TNF-induced activation of NF-kappa B, c-Jun N-terminal kinase, and apoptosis.

S. Manna, B. Aggarwal, A. Mukhopadhyay, 1999, Journal of immunology.

Chemopreventive Agents Induce Suppression of Nuclear Factor‐κB Leading to Chemosensitization

B. Aggarwal, A. Bharti, 2002, Annals of the New York Academy of Sciences.

Immunosuppressive leflunomide metabolite (A77 1726) blocks TNF-dependent nuclear factor-kappa B activation and gene expression.

S. Manna, B. Aggarwal, 1999, Journal of immunology.

The p60 Tumor Necrosis Factor (TNF) Receptor-associated Kinase (TRAK) Binds Residues 344–397 within the Cytoplasmic Domain Involved in TNF Signaling (*)

B. Aggarwal, M. Chaturvedi, Sanjaya Singh, 1995, The Journal of Biological Chemistry.

Regulation of proliferation, survival and apoptosis by members of the TNF superfamily.

B. Aggarwal, Upasna Gaur, Bharat B Aggarwal, 2003, Biochemical pharmacology.

Tumor necrosis factor and lymphotoxin. Qualitative and quantitative differences in the mediation of early and late cellular response.

B. Aggarwal, M. Chaturvedi, R. Lapushin, 1994, The Journal of biological chemistry.

Oleandrin suppresses activation of nuclear transcription factor-kappaB, activator protein-1, and c-Jun NH2-terminal kinase.

N. K. Sah, S. Manna, B. Aggarwal, 2000, Cancer research.

Cancer-linked targets modulated by curcumin.

B. Aggarwal, N. Hasima, 2012, International journal of biochemistry and molecular biology.

Nuclear factor-kappaB activation: from bench to bedside.

Gautam Sethi, B. Aggarwal, G. Sethi, 2008, Experimental biology and medicine.

Cellular resistance to vincristine suppresses NF-kappa B activation and apoptosis but enhances c-Jun-NH2-terminal protein kinase activation by tumor necrosis.

B. Aggarwal, P. Pantazis, D. Giri, 1999, Apoptosis : an international journal on programmed cell death.

Nuclear factor-kappaB: its role in health and disease.

B. Aggarwal, Ashok Kumar, Y. Takada, 2004, Journal of molecular medicine.

Curcumin and liver cancer: a review.

B. Aggarwal, A. Bishayee, A. Darvesh, 2012, Current pharmaceutical biotechnology.

Activation of NF-kappaB by RANK requires tumor necrosis factor receptor-associated factor (TRAF) 6 and NF-kappaB-inducing kinase. Identification of a novel TRAF6 interaction motif.

B. Aggarwal, P. Moore, J. Ni, 1999, The Journal of biological chemistry.

Synthetic Vpr Protein Activates Activator Protein-1, c-Jun N-terminal Kinase, and NF-κB and Stimulates HIV-1 Transcription in Promonocytic Cells and Primary Macrophages*

C. Van Lint, B. Aggarwal, B. Roques, 2005, Journal of Biological Chemistry.

Review Article Cancer-linked targets modulated by curcumin

B. Aggarwal, N. Hasima, 2012 .

Expression of nuclear transcription factor kappa B in locally advanced human cervical cancer treated with definitive chemoradiation.

T. Buchholz, B. Aggarwal, A. Kunnumakkara, 2010, International journal of radiation oncology, biology, physics.

Delivery of antiinflammatory nutraceuticals by nanoparticles for the prevention and treatment of cancer.

B. Aggarwal, R. Kannappan, B. Sung, 2010, Biochemical pharmacology.

Damage to mitochondrial electron transport and energy coupling by visible light.

B. Aggarwal, L. Packer, A. Quintanilha, 1978, Biochimica et biophysica acta.

Gambogic acid inhibits angiogenesis and prostate tumor growth by suppressing vascular endothelial growth factor receptor 2 signaling.

Mingyao Liu, Z. Yi, Jian Luo, 2008, Cancer research.

Correction: Boswellic Acid Suppresses Growth and Metastasis of Human Pancreatic Tumors in an Orthotopic Nude Mouse Model through Modulation of Multiple Targets

B. Aggarwal, S. Prasad, Byoungduck Park, 2012, PloS one.

Evidence that genetic deletion of the TNF receptor p60 or p80 in macrophages modulates RANKL-induced signaling.

B. Aggarwal, Y. Takada, 2004, Blood.

Genetic Deletion of the TNF Receptor p 60 or p 80 in Macrophages Modulates RANKL-Induced Signaling

B. Aggarwal, Y. Takada, 2004 .

Dietary nutraceuticals as backbone for bone health.

M. Shakibaei, B. Aggarwal, Subash C. Gupta, 2018, Biotechnology advances.

Ursolic Acid, a Pentacyclin Triterpene, Potentiates TRAIL-induced Apoptosis through p53-independent Up-regulation of Death Receptors

B. Aggarwal, R. Kannappan, S. Prasad, 2010, The Journal of Biological Chemistry.

TRANK, a novel cytokine that activates NF-kappa B and c-Jun N-terminal kinase.

B. Aggarwal, Y. Zhai, L. V. Van Eldik, 1998, Journal of immunology.

Nuclear transcription factor-kappaB as a target for cancer drug development.

B. Aggarwal, B B Aggarwal, A Garg, 2002, Leukemia.

IFN-α Suppresses Activation of Nuclear Transcription Factors NF-κB and Activator Protein 1 and Potentiates TNF-Induced Apoptosis1

S. Manna, B. Aggarwal, A. Mukhopadhyay, 2000, The Journal of Immunology.

Protein kinase D1 promotes anchorage‐independent growth, invasion, and angiogenesis by human pancreatic cancer cells

B. Aggarwal, Z. Tong, B. Sung, 2011, Journal of cellular physiology.

Characterization of specific high affinity receptors for human tumor necrosis factor on mouse fibroblasts.

B. Aggarwal, P. Hass, M. Mohler, 1985, The Journal of biological chemistry.

Cutting Edge: TRANK, a Novel Cytokine That Activates NF-κB and c-Jun N-Terminal Kinase

B. Aggarwal, Y. Zhai, Guo-liang Yu, 1998, The Journal of Immunology.

A novel homologous recombination system to study 92 kDa type IV collagenase transcription demonstrates that the NFκB motif drives the transition from a repressed to an activated state of gene expression

B. Aggarwal, D. Boyd, Chunhong Yan, 2004, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Advances in Experimental Medicine and Biology

B. Aggarwal, M. Elias, E. Chabrière, 2014 .

PTEN down regulates AP-1 and targets c-fos in human glioma cells Via PI3-kinase/Akt pathway

B. Aggarwal, W. Yung, K. Bhat, 2007, Molecular and Cellular Biochemistry.

A Synthetic Triterpenoid, CDDO-Me, Inhibits IκBα Kinase and Enhances Apoptosis Induced by TNF and Chemotherapeutic Agents through Down-Regulation of Expression of Nuclear Factor κB–Regulated Gene Products in Human Leukemic Cells

M. Konopleva, M. Andreeff, B. Aggarwal, 2006, Clinical Cancer Research.

Nuclear Transcription Factor-κB: A Drug Target for all Seasons

B. Aggarwal, A. Garg, 2005 .

N-(4-Hydroxyphenyl)Retinamide Inhibits Invasion, Suppresses Osteoclastogenesis, and Potentiates Apoptosis through Down-regulation of IκBα Kinase and Nuclear Factor-κB–Regulated Gene Products

R. Lotan, B. Aggarwal, S. Shishodia, 2005 .

Melanoma Differentiation-Associated Gene-7/IL-24 Gene Enhances NF-κB Activation and Suppresses Apoptosis Induced by TNF

B. Aggarwal, A. Mhashilkar, S. Chada, 2004, The Journal of Immunology.

Nuclear factor-&kgr;B as a predictor of treatment response in breast cancer

Bharat B. Aggarwal, A. Garg, G. Hortobagyi, 2003 .

Transcription factors as targets for drug development

B. Aggarwal, D. Karunagaran, 2002 .

Apoptosis and nuclear factor-κb: a tale of association and dissociation

B. Aggarwal, 2000 .

IL-13 Suppresses TNF-Induced Activation of Nuclear Factor-κB, Activation Protein-1, and Apoptosis

S. Manna, B. Aggarwal, 1998, The Journal of Immunology.

Human immunodeficiency virus-1-tat protein induces the cell surface expression of endothelial leukocyte adhesion molecule-1, vascular cell adhesion molecule-1, and intercellular adhesion molecule-1 in human endothelial cells.

R. Puri, B. Aggarwal, J. Masson, 1997, Blood.

Garcinol Potentiates TRAIL-Induced Apoptosis through Modulation of Death Receptors and Antiapoptotic Proteins

B. Aggarwal, S. Prasad, B. Sung, 2010, Molecular Cancer Therapeutics.

Ursolic acid, a pentacyclin triterpene, potentiates TRAIL-induced apoptosis through p53-independent up-regulation of death receptors. EVIDENCE FOR THE ROLE OF REACTIVE OXYGEN SPECIES AND JNK.

B. Aggarwal, R. Kannappan, S. Prasad, 2016, The Journal of Biological Chemistry.

Nimbolide Sensitizes Human Colon Cancer Cells to TRAIL through Reactive Oxygen Species- and ERK-dependent Up-regulation of Death Receptors, p53, and Bax*

B. Aggarwal, Subash C. Gupta, Byoungduck Park, 2010, The Journal of Biological Chemistry.

Ranking the role of RANK ligand in apoptosis

B. Aggarwal, A. Bharti, 2004, Apoptosis.

Induction of endothelial cell surface adhesion molecules by tumor necrosis factor is blocked by protein tyrosine phosphatase inhibitors: Role of the nuclear transcription factor NF‐xB

B. Aggarwal, Sanjaya Singh, S. Dhawan, 1997, European journal of immunology.

α-Lipoic acid is a potent inhibitor of NF-κB activation in human T cells

B. Aggarwal, L. Packer, Yuichiro J. Suzuki, 1992 .

Nuclear factor-κB: The enemy within

B. Aggarwal, 2004 .

Inflammation, Lifestyle and Chronic Diseases : The Silent Link

B. Aggarwal, S. Guha, S. Krishnan, 2011 .

Azadirone, a Limonoid Tetranortriterpene, Induces Death Receptors and Sensitizes Human Cancer Cells to Tumor Necrosis Factor-related Apoptosis-inducing Ligand (TRAIL) through a p53 Protein-independent Mechanism

Y. Mo, B. Aggarwal, Subash C. Gupta, 2013, The Journal of Biological Chemistry.

Emerging molecular targets in esophageal cancers.

J. Ajani, Tsung-Teh Wu, M. Hung, 2007, Gastrointestinal cancer research : GCR.

Multitargeting Effects of Calebin A on Malignancy of CRC Cells in Multicellular Tumor Microenvironment

M. Shakibaei, B. Aggarwal, A. Kunnumakkara, 2021, Frontiers in Oncology.

Human Cytokines: Handbook for Basic and Clinical Research

B. Aggarwal, J. Gutterman, 1996 .

Assay for redox-sensitive transcription factor.

B. Aggarwal, A. Mukhopadhyay, M. Chaturvedi, 2000, Methods in enzymology.

Zerumbone down-regulates chemokine receptor CXCR4 expression leading to inhibition of CXCL12-induced invasion of breast and pancreatic tumor cells.

Mingyao Liu, B. Aggarwal, K. Ahn, 2008, Cancer research.

Modulation of the growth of transformed cells by human tumor necrosis factor-alpha and interferon-gamma.

B. Aggarwal, H. Shepard, B. Sugarman, 1987, Cancer research.

The p80 TNF receptor‐associated kinase (p80TRAK) associates with residues 354–397 of the p80 cytoplasmic domain: similarity to casein kinase

B. Aggarwal, Sanjaya Singh, B. Darnay, 1997, FEBS letters.

Induction of interleukin-2 receptor by tumor necrosis factor α on cultured ovarian tumor-associated lymphocytes

B. Aggarwal, R. Pandita, R. Freedman, 1992, Cancer Immunology, Immunotherapy.

Capsazepine, a TRPV1 antagonist, sensitizes colorectal cancer cells to apoptosis by TRAIL through ROS-JNK-CHOP-mediated upregulation of death receptors.

B. Aggarwal, S. Prasad, B. Sung, 2012, Free radical biology & medicine.

Induction of Matrix Metalloproteinase-9 Requires a Polymerized Actin Cytoskeleton in Human Malignant Glioma Cells*

Raymond Sawaya, Z. Gokaslan, B. Aggarwal, 1998, The Journal of Biological Chemistry.

Okadaic acid induces down-modulation and shedding of tumor necrosis factor receptors. Comparison with another tumor promoter, phorbol ester.

B. Aggarwal, M. Higuchi, 1993, The Journal of biological chemistry.

Piceatannol Inhibits TNF-Induced NF-κB Activation and NF-κB-Mediated Gene Expression Through Suppression of IκBα Kinase and p65 Phosphorylation1

Sanjeev Banerjee, B. Aggarwal, S. Shishodia, 2002, The Journal of Immunology.

Piceatannol inhibits TNF-induced NF-kappaB activation and NF-kappaB-mediated gene expression through suppression of IkappaBalpha kinase and p65 phosphorylation.

Sanjeev Banerjee, B. Aggarwal, S. Shishodia, 2002, Journal of immunology.

In vivo induction of nitrite and nitrate by tumor necrosis factor, lymphotoxin, and interleukin-1: possible roles in malaria

B. Aggarwal, I. Clark, K. Rockett, 1992, Infection and immunity.

Both type I and type II interferons down‐regulate human tumor necrosis factor receptors in human hepatocellular carcinoma cell line Hep G2

B. Aggarwal, R. Pandita, 1994, FEBS letters.

Inhibition of Radiation-Induced DNA Repair and Prosurvival Pathways Contributes to Vorinostat-Mediated Radiosensitization of Pancreatic Cancer Cells

B. Aggarwal, V. Puduvalli, S. Guha, 2010, Pancreas.

VEGI, a novel cytokine of the tumor necrosis factor family, is an angiogenesis inhibitor that suppresses the growth of colon carcinomas in vivo

B. Aggarwal, R. Gentz, S. Ruben, 1999, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Gossypin, a pentahydroxy glucosyl flavone, inhibits the transforming growth factor beta-activated kinase-1-mediated NF-kappaB activation pathway, leading to potentiation of apoptosis, suppression of invasion, and abrogation of osteoclastogenesis.

Z. Yi, B. Aggarwal, K. Ahn, 2007, Blood.

Transcriptional up-regulation of interleukin 4 receptors by human immunodeficiency virus type 1 tat gene.

R. Puri, B. Aggarwal, P. Leland, 1996, AIDS research and human retroviruses.

Resveratrol, a multitargeted agent, can enhance antitumor activity of gemcitabine in vitro and in orthotopic mouse model of human pancreatic cancer

B. Aggarwal, G. Sethi, K. Harikumar, 2010, International journal of cancer.

Curcumin Downregulates NF-kB and Related Genes in Patients with Multiple Myeloma: Results of a Phase I/II Study.

Michael L. Wang, B. Aggarwal, C. Bueso-Ramos, 2007 .

B. Aggarwal, R. Kannappan, S. Prasad, 2010, The Journal of Biological Chemistry.

Cancer Therapy : Preclinical Nimbolide , a Limonoid Triterpene , Inhibits Growth of Human Colorectal Cancer Xenografts by Suppressing the Proin fl ammatory Microenvironment

Y. Mo, B. Aggarwal, S. Prasad, 2013 .

Tocotrienols fight cancer by targeting multiple cell signaling pathways

Bharat B. Aggarwal, Ji Hye Kim, Ramaswamy Kannappan, 2011, Genes & Nutrition.

Lead exposure activates nuclear factor kappa B, activator protein-1, c-Jun N-terminal kinase and caspases in the rat brain.

S. Manna, B. Aggarwal, G. Ramesh, 2001, Toxicology letters.

Chapter 9 Human cytokines

B. Aggarwal, B. Darnay, 1996 .

Primary structure of human lymphotoxin derived from 1788 lymphoblastoid cell line.

W. Kohr, B. Aggarwal, W. Henzel, 1985, The Journal of biological chemistry.

Emodin (3-methyl-1,6,8-trihydroxyanthraquinone) inhibits TNF-induced NF-κB activation, IκB degradation, and expression of cell surface adhesion proteins in human vascular endothelial cells

B. Aggarwal, Ashok J. Kumar, S. Dhawan, 1998, Oncogene.

Muramyl dipeptide induces production of hemopoietic growth factors in vivo by a mechanism independent of tumor necrosis factor.

J. Adamson, B. Aggarwal, V. Broudy, 1990, Journal of Immunology.

Curcumin potentiates the apoptotic effects of chemotherapeutic agents and cytokines through down-regulation of nuclear factor-kappaB and nuclear factor-kappaB-regulated gene products in IFN-alpha-sensitive and IFN-alpha-resistant human bladder cancer cells.

B. Aggarwal, G. Sethi, A. Kamat, 2007, Molecular cancer therapeutics.

Inhibition of growth and survival of human head and neck squamous cell carcinoma cells by curcumin via modulation of nuclear factor-kappaB signaling.

Sujay K. Singh, B. Aggarwal, J. Myers, 2004, International journal of cancer.

Simvastatin potentiates TNF-alpha-induced apoptosis through the down-regulation of NF-kappaB-dependent antiapoptotic gene products: role of IkappaBalpha kinase and TGF-beta-activated kinase-1.

B. Aggarwal, G. Sethi, K. Ahn, 2007, Journal of immunology.

Suppression of the Nuclear Factor‐κB Activation Pathway by Spice‐Derived Phytochemicals: Reasoning for Seasoning

B. Aggarwal, S. Shishodia, 2004, Annals of the New York Academy of Sciences.

Therapeutic Significance of Elevated Tissue Transglutaminase Expression in Pancreatic Cancer

B. Aggarwal, A. Sood, A. Verma, 2008, Clinical Cancer Research.

PARP cleavage and caspase activity to assess chemosensitivity.

B. Aggarwal, Y. Takada, A. Bharti, 2005, Methods in molecular medicine.

A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease

Diane D. Liu, W. Hong, I. Wistuba, 2013 .

Purification and characterization of early pregnancy factor from human pregnancy sera.

B. Aggarwal, T. Eessalu, A. R. Mehta, 1989, The Journal of biological chemistry.

Reconstitution of nuclear factor kappa B activation induced by tumor necrosis factor requires membrane-associated components. Comparison with pathway activated by ceramide.

B. Aggarwal, M. Chaturvedi, B. Darnay, 1994, The Journal of biological chemistry.

{Gamma}-tocotrienol inhibits pancreatic tumors and sensitizes them to gemcitabine treatment by modulating the inflammatory microenvironment.

B. Aggarwal, Z. Tong, B. Sung, 2010, Cancer research.

Anticancer drugs designed by mother nature: ancient drugs but modern targets.

B. Aggarwal, Y. Kashiwada, H. Ichikawa, 2007, Current pharmaceutical design.

Pinitol targets nuclear factor-κB activation pathway leading to inhibition of gene products associated with proliferation, apoptosis, invasion, and angiogenesis

Bharat B. Aggarwal, Gautam Sethi, B. Aggarwal, 2008, Molecular Cancer Therapeutics.

Role of tumor necrosis factor receptors in the activation of nuclear factor kappa B in human histiocytic lymphoma U-937 cells.

B. Aggarwal, B B Aggarwal, H Chan, 1994, The Journal of biological chemistry.

Phase I study of tumor necrosis factor plus actinomycin D in patients with androgen-independent prostate cancer.

A Sella, B. Aggarwal, B B Aggarwal, 1995, Cancer biotherapy.

γ-Tocotrienol but Not γ-Tocopherol Blocks STAT3 Cell Signaling Pathway through Induction of Protein-tyrosine Phosphatase SHP-1 and Sensitizes Tumor Cells to Chemotherapeutic Agents*

B. Aggarwal, R. Kannappan, V. Yadav, 2010, The Journal of Biological Chemistry.

5-Hydroxy-2-Methyl-1,4-Naphthoquinone, a Vitamin K3 Analogue, Suppresses STAT3 Activation Pathway through Induction of Protein Tyrosine Phosphatase, SHP-1: Potential Role in Chemosensitization

B. Aggarwal, B. Sung, S. Sandur, 2010, Molecular Cancer Research.

Proceedings of the Indo-U.S. bilateral workshop on accelerating botanicals/biologics agent development research for cancer chemoprevention, treatment, and survival

F. Sarkar, E. Hawk, B. Aggarwal, 2013, Cancer medicine.

Chemopreventive and chemotherapeutic potential of curcumin in breast cancer.

B. Aggarwal, A. Bishayee, B. Sung, 2012, Current drug targets.

Curcumin, the Holistic Avant-Garde

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2017 .

Nuclear factor‐κB and IκB kinase are constitutively active in human pancreatic cells, and their down‐regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis

B. Aggarwal, R. Kurzrock, S. Shishodia, 2004, Cancer.

Expression of NF‐κB parallels COX‐2 expression in oral precancer and cancer: Association with smokeless tobacco

B. Aggarwal, G. Sethi, S. Shishodia, 2007, International journal of cancer.

Modulation of two forms of tumor necrosis factor receptors and their cellular response by soluble receptors and their monoclonal antibodies.

B. Aggarwal, M. Higuchi, 1992, The Journal of biological chemistry.

Forecasting Nutrition Research in 2020

B. Aggarwal, R. deVere White, D. Heber, 2014, Journal of the American College of Nutrition.

Nuclear Factor-κB and Chemoresistance: How Intertwined Are They?

B. Aggarwal, A. Kunnumakkara, P. Anand, 2009 .

Anti-inflammatory Nutraceuticals and Chronic Diseases

B. Aggarwal, S. Prasad, Subash C. Gupta, 2016, Advances in Experimental Medicine and Biology.

Zyflamend sensitizes tumor cells to TRAIL-induced apoptosis through up-regulation of death receptors and down-regulation of survival proteins: role of ROS-dependent CCAAT/enhancer-binding protein-homologous protein pathway.

B. Aggarwal, J. Kim, R. Kannappan, 2012, Antioxidants & redox signaling.

Zyflamend, a polyherbal preparation, inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of NF-kappa B activation and NF-kappa B-regulated gene products.

B. Aggarwal, G. Sethi, S. Shishodia, 2007, Nutrition and cancer.

116. Curcumin inhibits tumor growth and angiogenesis in ovarian carcinoma by targeting the nuclear factor-κB pathway

B. Aggarwal, A. Sood, S. Lutgendorf, 2009, Brain, Behavior, and Immunity.

Nuclear factor-kappa B as a predictor of treatment response in breast cancer.

A. Garg, G. Hortobagyi, T. Buchholz, 2003, Current opinion in oncology.

Diosgenin inhibits osteoclastogenesis, invasion, and proliferation through the downregulation of Akt, I kappa B kinase activation and NF-kappa B-regulated gene expression.

B. Aggarwal, S. Shishodia, 2006, Oncogene.

Betulinic acid suppresses carcinogen-induced NF-kappa B activation through inhibition of I kappa B alpha kinase and p65 phosphorylation: abrogation of cyclooxygenase-2 and matrix metalloprotease-9.

B. Aggarwal, Y. Takada, 2003, Journal of immunology.

Therapeutic Potential of Curcumin Derived from Turmeric (Curcuma longa)

B. Aggarwal, A. Bharti, Anushree Kumar, 2004 .

Epidermal growth factor down‐regulates the expression of neutrophil gelatinase‐associated lipocalin (NGAL) through E‐cadherin in pancreatic cancer cells

S. Batra, B. Aggarwal, Sendurai A Mani, 2011, Cancer.

Sethi G, Ahn KS, Pandey MK, Aggarwal BB. Celastrol, a novel triterpene, potentiates TNF-induced apoptosis and suppresses invasion of tumor cells by inhibiting NF-κB-regulated gene products and TAK1-mediated NF-κB activation. Blood. 2007;109(7):2727-2735.

B. Aggarwal, G. Sethi, K. Ahn, 2013, Blood.

Role of anti-inflammatory agents in the treatment of lymphoma

B. Aggarwal, M. Pandey, 2015 .

Effect of Low-Fat Diets on Plasma Levels of NF-κB–Regulated Inflammatory Cytokines and Angiogenic Factors in Men with Prostate Cancer

M. Dewhirst, K. Do, B. Aggarwal, 2011, Cancer Prevention Research.

Calebin A, a novel component of turmeric, suppresses NF-κB regulated cell survival and inflammatory gene products leading to inhibition of cell growth and chemosensitization.

B. Aggarwal, S. Prasad, A. Tyagi, 2017, Phytomedicine : international journal of phytotherapy and phytopharmacology.

Evidence that TNF-β suppresses osteoblast differentiation of mesenchymal stem cells and resveratrol reverses it through modulation of NF-κB, Sirt1 and Runx2

M. Shakibaei, B. Aggarwal, B. Constanze, 2020, Cell and Tissue Research.

Evidence that GTP-binding domain but not catalytic domain of transglutaminase 2 is essential for epithelial-to-mesenchymal transition in mammary epithelial cells

B. Aggarwal, Dihua Yu, B. Sung, 2012, Breast Cancer Research.

Nuclear factor-κB: a transcription factor for all seasons

B. Aggarwal, 2007 .

Nuclear factor-kappa B: a transcription factor for all seasons.

B. Aggarwal, 2007, Expert opinion on therapeutic targets.

Upside and Downside of Tumor Necrosis Factor Blockers for Treatment of Immune/Inflammatory Diseases.

B. Aggarwal, A. Kunnumakkara, K. Thakur, 2019, Critical reviews in immunology.

Curcumin sensitizes human colorectal cancer to capecitabine by modulation of cyclin D1, COX-2, MMP-9, VEGF and CXCR4 expression in an orthotopic mouse model (International Journal of Cancer (2009) 125, (2187-2197))

B. Aggarwal, A. Kunnumakkara, S. Guha, 2010 .

2607 : Curcumin Enhances Colorectal Cancer Cell Radiosensitivity by Suppressing the Radiation-Induced Nuclear Factor-kappaB (NF-kB) Pathway

B. Aggarwal, Sunil Krishnan, S. Sandur, 2006 .

Erratum: Celastrol suppresses invasion of colon and pancreatic cancer cells through the downregulation of expression of CXCR4 chemokine receptor (Journal of Molecular Medicine (2010) 88: 12 (1243-1253) DOI: 10.1007/s00109-010-0669-3)

Mingyao Liu, B. Aggarwal, R. Kannappan, 2013 .

Acetyl-11-keto-beta-boswellic acid potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis by suppressing NF-kappa B and NF-kappa B-regulated gene expression.

B. Aggarwal, Y. Takada, V. Badmaev, 2006, Journal of immunology.

Curcumin: The Biochemistry Behind Its Anticancer Effects

B. Aggarwal, A. Kunnumakkara, P. Anand, 2009 .

The Double-Stranded RNA-Activated Protein Kinase Mediates Radiation Resistance in Mouse Embryo Fibroblasts through Nuclear Factor κB and Akt Activation

K. Hunt, J. Roth, S. Swisher, 2007, Clinical Cancer Research.

Epidermal growth factor (EGF) activates nuclear factor-κB through IκBα kinase-independent but EGF receptor-kinase dependent tyrosine 42 phosphorylation of IκBα

B. Aggarwal, G. Sethi, K. Ahn, 2015, Oncogene.

Nuclear Transcription Factor-kappaB in Hodgkin's Disease

B. Aggarwal, A. Younes, A. Garg, 2003, Leukemia & lymphoma.

Protein tyrosine kinase inhibitors block tumor necrosis factor-induced activation of nuclear factor-kappaB, degradation of IkappaBalpha, nuclear translocation of p65, and subsequent gene expression.

S. Manna, B. Aggarwal, M. Chaturvedi, 1998, Archives of biochemistry and biophysics.

Isodeoxyelephantopin, a novel sesquiterpene lactone, potentiates apoptosis, inhibits invasion, and abolishes osteoclastogenesis through suppression of nuclear factor-kappaB (nf-kappaB) activation and nf-kappaB-regulated gene expression.

B. Aggarwal, Y. Takada, O. Oommen, 2006, Clinical cancer research : an official journal of the American Association for Cancer Research.

Cell density‐dependent regulation of cell surface expression of two types of human tumor necrosis factor receptors and its effect on cellular response

B. Aggarwal, F. Ali-Osman, Eva Pocsik, 1994, Journal of cellular biochemistry.

Induction of receptors for tumor necrosis factor-alpha by interferons is not a major mechanism for their synergistic cytotoxic response.

B. Aggarwal, T. Eessalu, 1987, The Journal of biological chemistry.

Targeted deletion of MKK4 gene potentiates TNF-induced apoptosis through the down-regulation of NF-kappa B activation and NF-kappa B-regulated antiapoptotic gene products.

B. Aggarwal, G. Sethi, J. Kurie, 2007, Journal of Immunology.

Response to Kurien and Scofield: Solubility and bioavailability of curcumin

B. Aggarwal, 2009 .

Amplified expression of the HER2/ERBB2 oncogene induces resistance to tumor necrosis factor a in NIH 3T3 cells (gene amplification/receptor transmodulation/tumorigenesis)

A. Ullrich, B. Aggarwal, T. Eessalu, 2022 .

Down-modulation of cell surface expression of p80 form of the tumor necrosis factor receptor by human immunodeficiency virus-1 tat gene.

B. Aggarwal, M. Higuchi, É. Pócsik, 1992, Lymphokine and cytokine research.

Characterization and mechanistic studies of a novel melanoma-targeting construct containing IκBa for specific inhibition of nuclear factor-κB activity.

B. Aggarwal, W. Hittelman, M. Rosenblum, 2010, Neoplasia.

Lead activates nuclear transcription factor-kappaB, activator protein-1, and amino-terminal c-Jun kinase in pheochromocytoma cells.

S. Manna, B. Aggarwal, G. Ramesh, 1999, Toxicology and applied pharmacology.

Acidic sphingomyelinase-generated ceramide is needed but not sufficient for TNF-induced apoptosis and nuclear factor-kappa B activation.

B. Aggarwal, J. Jaffrezou, M. Higuchi, 1996, Journal of immunology.

B. Aggarwal, R. Kannappan, S. Prasad, 2011 .

EFFECTS OF VISIBLE LIGHT EXPOSURE ON MITOCHONDRIAL STRUCTURE AND FUNCTION

B. Aggarwal, 1977 .

γ-Tocotrienol but not γ-tocopherol blocks STAT3 cell signaling pathway through induction of protein-tyrosine phosphatase SHP-1 and sensitizes tumor cells to chemotherapeutic agents.

B. Aggarwal, R. Kannappan, V. Yadav, 2016, The Journal of Biological Chemistry.

Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL.

B. Aggarwal, S. Prasad, B. Sung, 2016, The Journal of Biological Chemistry.

Crotepoxide chemosensitizes tumor cells through inhibition of expression of proliferation, invasion, and angiogenic proteins linked to proinflammatory pathway.

B. Aggarwal, S. Prasad, M. Chaturvedi, 2016, The Journal of Biological Chemistry.

Nimbolide sensitizes human colon cancer cells to TRAIL through reactive oxygen species- and ERK-dependent up-regulation of death receptors, p53, and Bax.

B. Aggarwal, Subash C. Gupta, Byoungduck Park, 2016, The Journal of Biological Chemistry.

Correction: Gossypol induces death receptor-5 through activation of ROS-ERK-CHOP pathway and sensitizes colon cancer cells to TRAIL (Journal of Biological Chemistry (2010) 285 (35418-35427))

B. Aggarwal, S. Prasad, B. Sung, 2016 .

Correction: Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors (Journal of Biological Chemistry (2010) 285, (11498-11507))

B. Aggarwal, Byoungduck Park, B. Sung, 2016 .

Celastrol, a triterpene, enhances TRAIL-induced apoptosis through the down-regulation of cell survival proteins and up-regulation of death receptors.

B. Aggarwal, Byoungduck Park, B. Sung, 2016, The Journal of Biological Chemistry.

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of NF-κ B Signaling Pathway

B. Aggarwal, K. Harikumar, S. Guha, 2010 .

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor- (cid:1) B Signaling Pathway

B. Aggarwal, K. Harikumar, S. Guha, 2010 .

Escin, a Pentacyclic Triterpene, Chemosensitizes Human Tumor Cells through Inhibition of Nuclear Factor- (cid:1) B Signaling Pathway

B. Aggarwal, K. Harikumar, S. Guha, 2010 .

The Multifaceted Role of Curcumin in Cancer Prevention and Treatment

B. Aggarwal, G. Sethi, F. Arfuso, 2015, Molecules.

Dovepress Open Access to Scientific and Medical Research Open Access Full Text Article Fabrication and Characterization of Silk Fibroin-derived Curcumin Nanoparticles for Cancer Therapy

A. Mathur, B. Aggarwal, Vishal K. Gupta, 2022 .

Advances in Brief Human Immunodeficiency Virus Type 1 tat Gene Upregulates Interleukin 4 Receptors on a Human B-Lymphoblastoid Cell Line

R. Puri, B. Aggarwal, 2006 .

Reversal of Chemoresistance and Enhancement of Apoptosis by Statins Through Downegulation of the NF- κ B pathway

B. Aggarwal, G. Sethi, K. Ahn, 2009 .

Inhibitory Effects of Black Pepper (Piper Nigrum) Extracts and Compounds on Human Tumor Cell Proliferation, Cyclooxygenase Enzymes, Lipid Peroxidation and Nuclear Transcription Factor-kappa-B

M. Nair, B. Aggarwal, Yunbao Liu, 2010, Natural product communications.

Multi-targeted approach to cancer treatment: an international translational cancer research symposium.

B. Aggarwal, S. Pathak, V. Gandhi, 2014, Anticancer Research.

Prevention and Treatment of Cancer: Hypes and Hopes 6th International Translational Cancer Research Conference.

B. Aggarwal, S. Pathak, V. Gandhi, 2016, Anticancer research.

Leaders in Translational Cancer Research Meet in Udaipur, a Historical Town of India: An International Symposium on Translational Cancer Research: Cancer Prevention. Udaipur, Rajasthan, India, December 16-19, 2011

B. Aggarwal, S. Pathak, V. Gandhi, 2013 .

City of temples discusses signaling templates in cancer cells. Third International Symposium on Translational Cancer Research: Cell Signaling & Cancer Therapy. Bhubaneswar, Orissa, India, December 18th through 21st, 2009.

Sandip K. Mishra, B. Aggarwal, S. Pathak, 2010, Anticancer research.

All pathways to cancer apoptosis meeting in Thiruvananthapuram (India)

B. Aggarwal, V. Gandhi, K. Mehta, 2006, Cell Death and Differentiation.

Human immunodeficiency virus type 1 tat gene up-regulates interleukin 4 receptors on a human B-lymphoblastoid cell line.

R. Puri, B. Aggarwal, 1992, Cancer research.

N-(4-hydroxyphenyl)retinamide inhibits invasion, suppresses osteoclastogenesis, and potentiates apoptosis through down-regulation of I(kappa)B(alpha) kinase and nuclear factor-kappaB-regulated gene products.

R. Lotan, B. Aggarwal, S. Shishodia, 2005, Cancer research.

Role of sulfhydryl groups in induction of cell surface down-modulation and shedding of extracellular domain of human TNF receptors in human histiocytic lymphoma U937 cells.

B. Aggarwal, L. Zhang, L. Zhang, 1994, Journal of immunology.

Tumor necrosis factors alpha and beta differ in their capacities to generate interleukin 1 release from human endothelial cells.

R. Locksley, B. Aggarwal, H. Shepard, 1987, Journal of immunology.

Acetyl-11-keto-beta-boswellic acid inhibits prostate tumor growth by suppressing vascular endothelial growth factor receptor 2-mediated angiogenesis.

Mingyao Liu, Xiufeng Pang, Z. Yi, 2009, Cancer research.

Aggarwal leukemia cells andmetastatic gene products and enhancement of apoptosis in myeloid B-regulated antiapoptotic and κ inhibition of expression of NF-kinase activation , causing α B κ B and I κ Indole-3-carbinol suppresses

M. Andreeff, B. Aggarwal, Y. Takada, 2005 .

Nuclear factor-kappaB: the enemy within.

B. Aggarwal, 2004, Cancer cell.

Thymoquinone poly (lactide-co-glycolide) nanoparticles exhibit enhanced anti-proliferative, anti-inflammatory, and chemosensitization potential.

B. Aggarwal, S. Prasad, R. Tekmal, 2010, Biochemical pharmacology.

Multitargeting by curcumin as revealed by molecular interaction studies.

B. Aggarwal, J. Kim, S. Prasad, 2011, Natural product reports.

Suppression of 7,12-dimethylbenz(a)anthracene-induced mammary carcinogenesis in rats by resveratrol: role of nuclear factor-kappaB, cyclooxygenase 2, and matrix metalloprotease 9.

Sanjeev Banerjee, B. Aggarwal, C. Bueso-Ramos, 2002, Cancer research.

Flavopiridol Suppresses TNF-Induced Activation of AP-1, JNK, p38 MAPK, p44/p42 MAPK and Akt, Inhibits Expression of Antiapoptotic Gene Products, and Enhances Apoptosis Through Cytochrome c Release and Caspase Activation in Human Myeloid Cells

B. Aggarwal, Y. Takada, Bokyung Sung, 2008 .

Curcumin-Free Turmeric Exhibits Activity against Human HCT-116 Colon Tumor Xenograft: Comparison with Curcumin and Whole Turmeric

B. Aggarwal, Z. Siddik, S. Prasad, 2017, Frontiers in Pharmacology.

Curcumin-free turmeric exhibits anti-inflammatory and anticancer activities: Identification of novel components of turmeric.

B. Aggarwal, Subash C. Gupta, Shiyou Li, 2013, Molecular nutrition & food research.

Multitargeting by turmeric, the golden spice: From kitchen to clinic.

B. Aggarwal, J. Kim, S. Prasad, 2013, Molecular nutrition & food research.

Curcumin mediates anticancer effects by modulating multiple cell signaling pathways.

B. Aggarwal, Subash C. Gupta, A. Kunnumakkara, 2017, Clinical science.

Lymphotoxin: Developments during the last decade

B. Aggarwal, Sanjaya Singh, 1997 .

Tumor necrosis factors - TNF-α and TNF-β: Their structure and pleiotropic biological effects

B. Aggarwal, 1987 .

Inhibition by all‐trans‐retinoic acid of tumor necrosis factor and nitric oxide production by peritoneal macrophages

B. Aggarwal, T. McQueen, K. Mehta, 1994, Journal of leukocyte biology.

Human lymphotoxin.

B. Aggarwal, 1985, Methods in enzymology.

R. Puri, B. Aggarwal, J. Masson, 1997, Blood.

Targeting TNF for Treatment of Cancer and Autoimmunity.

B. Aggarwal, G. Sethi, A. Kunnumakkara, 2009, Advances in experimental medicine and biology.

A pilot double-blind, randomized, placebo-controlled trial of curcumin/bioperine for lung cancer chemoprevention in patients with chronic obstructive pulmonary disease

Diane D. Liu, I. Wistuba, A. Sharafkhaneh, 2013 .

Curcumin Differs from Tetrahydrocurcumin for Molecular Targets, Signaling Pathways and Cellular Responses

B. Aggarwal, S. Prasad, L. Deb, 2014, Molecules.

Acquisition of cellular resistance to 9-nitro-camptothecin correlates with suppression of transcription factor NF-kappa B activation and potentiation of cytotoxicity by tumor necrosis factor in human histiocytic lymphoma U-937 cells.

B. Aggarwal, P. Pantazis, U. Raju, 1998, Anti-cancer drugs.

Tocotrienols, the vitamin E of the 21st century: its potential against cancer and other chronic diseases.

B. Aggarwal, R. Kannappan, C. Sundaram, 2010, Biochemical pharmacology.

Plumbagin Inhibits Osteoclastogenesis and Reduces Human Breast Cancer-Induced Osteolytic Bone Metastasis in Mice through Suppression of RANKL Signaling

B. Aggarwal, B. Oyajobi, Bokyung Sung, 2011, Molecular Cancer Therapeutics.

Upside and Downside of Tumor Necrosis Factor Blockers for Treatment of Immune/Inflammatory Diseases.

B. Aggarwal, A. Kunnumakkara, K. Thakur, 2019, Critical reviews in immunology.

Diminished responsiveness of senescent normal human fibroblasts to TNF-dependent proliferation and interleukin production is not due to its effect on the receptors or on the activation of a nuclear factor NF-kappa B.

J. R. Smith, B. Aggarwal, R. Lapushin, 1995, Experimental cell research.

Nuclear factor-κB: a friend or a foe in cancer?

B. Aggarwal, S. Shishodia, 2004 .

Nuclear Factor-κB: A Holy Grail in Cancer Prevention and Therapy

B. Aggarwal, G. Sethi, A. Nair, 2006 .

B. Aggarwal, A. Kunnumakkara, P. Anand, 2008, Molecular Cancer Therapeutics.

Guggulsterone inhibits NF-kappaB and IkappaBalpha kinase activation, suppresses expression of anti-apoptotic gene products, and enhances apoptosis.

B. Aggarwal, S. Shishodia, 2004, The Journal of biological chemistry.