A. Breeze

发表

Structure of an SH2 domain of the p85 alpha subunit of phosphatidylinositol-3-OH kinase.

I. Campbell, G. Booker, A. Breeze, 1992, Nature.

Isotope-filtered NMR methods for the study of biomolecular structure and interactions

A. Breeze, 2000 .

Landscape of activating cancer mutations in FGFR kinases and their differential responses to inhibitors in clinical use

C. Orengo, A. Breeze, P. Ashford, 2016, Oncotarget.

An integrated approach to fragment-based lead generation: philosophy, strategy and case studies from AstraZeneca's drug discovery programmes.

N. Blomberg, A. Breeze, S. Geschwindner, 2007, Current topics in medicinal chemistry.

Fragment‐Based Discovery of Inhibitors of Lactate Dehydrogenase A

A. Breeze, R. Ward, J. Winter, 2016 .

Design and synthesis of novel lactate dehydrogenase A inhibitors by fragment-based lead generation.

Jon Winter, David Whittaker, Gareth Davies, 2012, Journal of medicinal chemistry.

Pyrrolamide DNA Gyrase Inhibitors: Fragment-Based Nuclear Magnetic Resonance Screening To Identify Antibacterial Agents

Ning Gao, Haihong Ni, Oluyinka Green, 2011, Antimicrobial Agents and Chemotherapy.

Small molecule binding sites on the Ras:SOS complex can be exploited for inhibition of Ras activation.

Malcolm Anderson, Jason G Kettle, Alexander L Breeze, 2015, Journal of medicinal chemistry.

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR 1 kinase

A. Breeze, J. Tucker, R. A. Norman, 2015 .

Structural and dynamic insights into the energetics of activation loop rearrangement in FGFR1 kinase

A. Breeze, J. Tucker, R. A. Norman, 2015, Nature Communications.

Towards “bionic” proteins: replacement of continuous sequences from HIF-1α with proteomimetics to create functional p300 binding HIF-1α mimics† †Electronic supplementary information (ESI) available: Detailed experimental procedures and characterisation; additional biophysical data. See DOI: 10.1039/

A. Breeze, S. Warriner, A. Nelson, 2016, Chemical communications.

“Ligandability” of Drug Targets: Assessment of Chemical Tractability via Experimental and In Silico Approaches

A. Breeze, U. Bauer, 2016 .

Interactions between discrete neuronal membrane binding sites for the putative K+-channel ligands beta-bungarotoxin, dendrotoxin and mast-cell-degranulating peptide.

A. Breeze, J. Dolly, 1989, European journal of biochemistry.

Identification by cross‐linking of a neuronal acceptor protein for dendrotoxin, a convulsant polypeptide

A. Breeze, J. Dolly, F. Mehraban, 1984, FEBS letters.

Botulinum neurotoxin and dendrotoxin as probes for studies on transmitter release.

R. S. Williams, A. Breeze, J. Halliwell, 1984, Journal de physiologie.

A functional membranous acceptor for dendrotoxin in rat brain: solubilization of the binding component

A. Breeze, A. Black, J. Dolly, 1985 .

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

A. Breeze, M. Pons, S. Skinner, 2018, Journal of Biomolecular NMR.

The Leishmania PABP1–eIF4E4 interface: a novel 5′–3′ interaction architecture for trans-spliced mRNAs

A. Breeze, N. Zanchin, M. Walko, 2018, Nucleic acids research.

Dimers of D76N-β2-microglobulin display potent antiamyloid aggregation activity

A. Breeze, F. Sobott, M. Walko, 2022, The Journal of biological chemistry.

Structure of an SH2 domain of the p85α subunit of phosphatidylinositol-3-OH kinase

I. Campbell, G. Booker, A. Breeze, 1994, Nature.

Involvement of neuronal acceptors for dendrotoxin in its convulsive action in rat brain.

A. Breeze, A. Black, J. Dolly, 1986, The Biochemical journal.

Structural insights into FGFR kinase isoform selectivity: diverse binding modes of AZD4547 and ponatinib in complex with FGFR1 and FGFR4.

A. Breeze, J. Breed, J. Tucker, 2014, Structure.

Synthesis of highly functionalized oligobenzamide proteomimetic foldamers by late stage introduction of sensitive groups† †Electronic supplementary information (ESI) available. See DOI: 10.1039/c6ob00078a Click here for additional data file.

A. Breeze, S. Warriner, A. Nelson, 2016, Organic & biomolecular chemistry.

Exploration of the HIF-1α/p300 interface using peptide and Adhiron phage display technologies.

A. Breeze, S. Warriner, A. Nelson, 2015, Molecular bioSystems.

Small-Molecule Proteomimetic Inhibitors of the HIF-1α–p300 Protein–Protein Interaction

A. Breeze, S. Warriner, A. Nelson, 2014, Chembiochem : a European journal of chemical biology.

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074

A. Breeze, M. Katan, G. Thompson, 2018, Biomolecular NMR Assignments.

Refolding, purification, and characterization of a loop deletion mutant of human Bcl-2 from bacterial inclusion bodies.

I. Taylor, A. Breeze, M Anderson, 1999, Protein expression and purification.

Structure, activation and dysregulation of fibroblast growth factor receptor kinases: perspectives for clinical targeting

A. Breeze, B. Farrell, 2018, Biochemical Society transactions.

EFCAB4B (CRACR2A) genetic variants associated with COVID-19 fatality

A. Breeze, D. Wang, K. Simmons, 2022, medRxiv.

1H, 13C and 15N resonance assignment for the human K-Ras at physiological pH

A. Breeze, A. Golovanov, K. Embrey, 2012, Biomolecular NMR Assignments.

Structure-based design of protein tyrosine phosphatase-1B inhibitors.

Jon Read, Alexander L Breeze, A. Breeze, 2005, Bioorganic & medicinal chemistry letters.

Structure of a specific peptide complex of the carboxy‐terminal SH2 domain from the p85 alpha subunit of phosphatidylinositol 3‐kinase.

A. Breeze, J. Smith, S. Cartlidge, 1996, The EMBO journal.

Prevention of MKK6-dependent activation by binding to p38alpha MAP kinase.

Jon Read, Alexander L Breeze, Richard A Norman, 2005, Biochemistry.

Fragment screening to predict druggability (ligandability) and lead discovery success.

Rutger H A Folmer, Fredrik N B Edfeldt, Alexander L Breeze, 2011, Drug discovery today.

The role of the IT-state in D76N β2-microglobulin amyloid assembly: A crucial intermediate or an innocuous bystander?

S. Radford, A. Breeze, Hugh I. Smith, 2020, The Journal of Biological Chemistry.

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

M. McPherson, A. Breeze, T. Edwards, 2020, bioRxiv.

Solution structure of human calcitonin gene-related peptide by 1H NMR and distance geometry with restrained molecular dynamics.

I. Campbell, A. Breeze, R. Bazzo, 1991, Biochemistry.

Monitoring Ras Interactions with the Nucleotide Exchange Factor Son of Sevenless (Sos) Using Site-specific NMR Reporter Signals and Intrinsic Fluorescence*

A. Breeze, A. Golovanov, N. Vajpai, 2015, The Journal of Biological Chemistry.

Monitoring Ras : Sos interactions 1 Monitoring Ras Interactions with the Nucleotide Exchange Factor Sos using Site-specific NMR Reporter Signals and Intrinsic Fluorescence

A. Breeze, A. Golovanov, N. Vajpai, 2015 .

1H, 13C and 15N resonance assignment for the human K-Ras at physiological pH

A. Breeze, A. Golovanov, K. Embrey, 2013, Biomolecular NMR assignments.

FGFR1 Kinase Inhibitors: Close Regioisomers Adopt Divergent Binding Modes and Display Distinct Biophysical Signatures.

A. Breeze, J. Tucker, R. A. Norman, 2014, ACS medicinal chemistry letters.

Disease Variants of FGFR3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc37 in Hsp90 Chaperone System

Roger L. Williams, A. Breeze, D. Svergun, 2018, Structure.

Disease Variants of FGFR 3 Reveal Molecular Basis for the Recognition and Additional Roles for Cdc 37 in Hsp 90 Chaperone System

Roger L. Williams, A. Breeze, D. Svergun, 2022 .

Secondary structure and backbone dynamics of human granulocyte colony-stimulating factor in solution.

I. Campbell, A. Breeze, J. Boyd, 1994, Biochemistry.

Antibacterial Design Based on the Structures of Gyrase-Inhibitor Complexes

A. Breeze, D. Derbyshire, R. Pauptit, 1998 .

The high‐resolution crystal structure of a 24‐kDa gyrase B fragment from E. coli complexed with one of the most potent coumarin inhibitors, clorobiocin

A. Breeze, D. Wigley, J. Ladbury, 1997, Proteins.

Biophysical methods in drug discovery from small molecule to pharmaceutical.

Gareth Davies, Stefan Geschwindner, Nicola Colclough, 2013, Methods in molecular biology.

Target-Based Whole-Cell Screening by 1H NMR Spectroscopy**

Qing Cao, A. Breeze, S. McLeod, 2015, Angewandte Chemie.

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1

A. Breeze, N. Vajpai, M. Vogtherr, 2014, Biomolecular NMR assignments.

NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 1

A. Breeze, N. Vajpai, M. Vogtherr, 2013, Biomolecular NMR Assignments.

NMR trial models: experiences with the colicin immunity protein Im7 and the p85alpha C-terminal SH2-peptide complex.

A. Breeze, G. Murshudov, D. Derbyshire, 2001, Acta crystallographica. Section D, Biological crystallography.

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

A. Breeze, F. Sobott, I. Manfield, 2022, Nature Communications.

Tuning the rate of aggregation of hIAPP into amyloid using small-molecule modulators of assembly

S. Radford, A. Breeze, F. Sobott, 2022, Nature communications.

Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

H. Schwalbe, A. Breeze, B. Fürtig, 2017, Journal of biomolecular NMR.

Evaluation of 15N-detected H–N correlation experiments on increasingly large RNAs

H. Schwalbe, A. Breeze, B. Fürtig, 2017, Journal of Biomolecular NMR.

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy**

A. Breeze, S. McLeod, Ning Gao, 2014, Angewandte Chemie.

Farseer-NMR: automatic treatment, analysis and plotting of large, multi-variable NMR data

A. Breeze, S. Skinner, Miquel Pons, 2018, Journal of Biomolecular NMR.

NMR trial models : experiences with the colicin immunity protein Im 7 and the p 85 a C-terminal SH 2 ± peptide complex

A. Breeze, D. Derbyshire, R. Pauptit, 2001 .

Real-Time Monitoring of New Delhi Metallo-β-Lactamase Activity in Living Bacterial Cells by 1H NMR Spectroscopy**

A. Breeze, S. McLeod, Ning Gao, 2014, Angewandte Chemie.

RAS-inhibiting biologics identify and probe druggable pockets including an SII-α3 allosteric site

A. Breeze, H. Martin, D. Tomlinson, 2021, Nature Communications.