G. Waksman

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Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

D. Baltimore, J. Kuriyan, M. Overduin, 1993, Nature.

Binding of a high affinity phosphotyrosyl peptide to the Src SH2 domain: Crystal structures of the complexed and peptide-free forms

J. Kuriyan, D. Cowburn, G. Waksman, 1993, Cell.

Structural basis of chaperone function and pilus biogenesis.

G. Waksman, J. Pinkner, S. Hultgren, 1999, Science.

Allosteric signalling in the outer membrane translocation domain of PapC usher

M. Topf, G. Waksman, Irene Farabella, 2014, eLife.

Structure of the outer membrane complex of a type IV secretion system

Gabriel Waksman, Jorge Navaza, J. Navaza, 2009, Nature.

Structure of the outer membrane translocator domain of the Haemophilus influenzae Hia trimeric autotransporter

Gabriel Waksman, G. Waksman, G. Meng, 2006, The EMBO journal.

Protein oligomerization in the bacterial outer membrane (Review)

Gabriel Waksman, Han Remaut, G. Waksman, 2009, Molecular membrane biology.

Secretion systems in Gram-negative bacteria: structural and mechanistic insights

Gabriel Waksman, G. Waksman, Tiago R D Costa, 2015, Nature Reviews Microbiology.

Protein-Injection Machines in Bacteria

G. Waksman, J. Galán, 2018, Cell.

Type IV secretion in Gram‐negative and Gram‐positive bacteria

Gabriel Waksman, Elisabeth Grohmann, Steffen Backert, 2018, Current Topics in Microbiology and Immunology.

Structural and Molecular Biology of Type IV Secretion Systems.

G. Waksman, L. Terradot, C. Bergé, 2017, Current topics in microbiology and immunology.

Structural Biology of Bacterial Type IV Secretion Systems.

G. Waksman, Vidya Chandran Darbari, 2015, Annual review of biochemistry.

Recent advances in the structural and molecular biology of type IV secretion systems

Gabriel Waksman, G. Waksman, P. Christie, 2014, Current opinion in structural biology.

Structures of two core subunits of the bacterial type IV secretion system, VirB8 from Brucella suis and ComB10 from Helicobacter pylori.

Gabriel Waksman, Gordon A Leonard, Richard Bayliss, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Dimerization and interactions of Brucella suis VirB8 with VirB4 and VirB10 are required for its biological activity.

G. Waksman, C. Baron, R. Bayliss, 2006, Proceedings of the National Academy of Sciences of the United States of America.

Structural insights into the membrane-extracted dimeric form of the ATPase TraB from the Escherichia coli pKM101 conjugation system

G. Waksman, V. Receveur-Bréchot, E. Durand, 2011, BMC Structural Biology.

Biochemical Dissection of the ATPase TraB, the VirB4 Homologue of the Escherichia coli pKM101 Conjugation Machinery

G. Waksman, E. Durand, C. Oomen, 2010, Journal of bacteriology.

An Agrobacterium VirB10 Mutation Conferring a Type IV Secretion System Gating Defect

G. Waksman, E. Cascales, V. Chandran, 2011, Journal of bacteriology.

Rationally designed small compounds inhibit pilus biogenesis in uropathogenic bacteria

G. Waksman, J. Pinkner, S. Hultgren, 2006, Proceedings of the National Academy of Sciences.

The biology and enzymology of protein N-myristoylation.

G Waksman, J. Gordon, G. Waksman, 2001, The Journal of biological chemistry.

The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod

R. Glockshuber, G. Waksman, Tiago R D Costa, 2017, Structure.

Biochemical Characterization of Protein Complexes from the Helicobacter pylori Protein Interaction Map

Pierre Legrain, Gabriel Waksman, P. Legrain, 2004, Molecular & Cellular Proteomics.

Rapid and accurate calculation of relative binding affinities for the SH 2 domain using a computational grid

Shantenu Jha, Peter V. Coveney, Gabriel Waksman, 2006 .

Crystal Structure of Escherichia coli Thioredoxin Reductase Refined at 2 Å Resolution

J Kuriyan, G Waksman, J. Kuriyan, 1994 .

Cryo-EM Structure of a Relaxase Reveals the Molecular Basis of DNA Unwinding during Bacterial Conjugation

G. Waksman, G. Zanetti, Sandro Roier, 2017, Cell.

Bromopyridazinedione-mediated protein and peptide bioconjugationw

James R. Baker, Gabriel Waksman, Vijay Chudasama, 2011 .

The Biology and Enzymology of ProteinN-Myristoylation* 210

J. Gordon, G. Waksman, T. Farazi, 2001, The Journal of Biological Chemistry.

Structure of N-myristoyltransferase with bound myristoylCoA and peptide substrate analogs

G. Gokel, J. Gordon, G. Waksman, 1998, Nature Structural Biology.

Probing the "two-pronged plug two-holed socket" model for the mechanism of binding of the Src SH2 domain to phosphotyrosyl peptides: a thermodynamic study.

J. M. Bradshaw, G. Waksman, R. Grucza, 1998, Biochemistry.

Reconstitution of a minimal machinery capable of assembling periplasmic type IV pili

G. Waksman, A. Busch, K. Forest, 2017, Proceedings of the National Academy of Sciences.

Crystal structure of a vFlip-IKKgamma complex: insights into viral activation of the IKK signalosome.

C. Boshoff, G. Waksman, B. Wallace, 2008, Molecular cell.

The VirE1VirE2 complex of Agrobacterium tumefaciens interacts with single‐stranded DNA and forms channels

A. Engel, G. Waksman, P. van Gelder, 2005, Molecular microbiology.

New insights into heparin-induced FGF oligomerization

G. Waksman, A. Herr, 1998, Nature Structural Biology.

Design and synthesis of C-2 substituted thiazolo and dihydrothiazolo ring-fused 2-pyridones: pilicides with increased antivirulence activity.

G. Waksman, J. Pinkner, S. Hultgren, 2010, Journal of medicinal chemistry.

Crystal structure of the Legionella pneumophila Lpg2936 in complex with the cofactor S‐adenosyl‐L‐methionine reveals novel insights into the mechanism of RsmE family methyltransferases

G. Waksman, N. Pinotsis, 2017, Protein science : a publication of the Protein Society.

From conjugation to T4S systems in Gram‐negative bacteria: a mechanistic biology perspective

G. Waksman, 2019, EMBO reports.

Mutagenesis of the BH3 Domain of BAX Identifies Residues Critical for Dimerization and Killing

S. Korsmeyer, G. Waksman, A. Gross, 1998, Molecular and Cellular Biology.

A comparison of the biochemical and physiological properties of a polygalacturonase from two races of

G. Waksman, J. A. Bailey, J. Keon, 1990 .

Cryo-EM structure of a type IV secretion system

E. Orlova, Q. Cong, G. Waksman, 2022, Nature.

Preferential self-association of basic fibroblast growth factor is stabilized by heparin during receptor dimerization and activation.

R. Langer, C. Cooney, G. Waksman, 1996, Proceedings of the National Academy of Sciences of the United States of America.

Molecular cloning of a beta-glucosidase-encoding gene from Sclerotinia sclerotiorum by expression in Escherichia coli

G. Waksman, 1989, Current Genetics.

BIROn - Birkbeck Institutional Research Online

G. Waksman, N. Pinotsis, 2021 .

Cryo-EM structure of the bacteria-killing type IV secretion system core complex from Xanthomonas citri

G. Waksman, Tiago R D Costa, C. Farah, 2018 .

Bromopyridazinedione-mediated protein and peptide bioconjugation† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc12807h Click here for additional data file.

Mark E. B. Smith, G. Waksman, S. Caddick, 2011, Chemical communications.

Structural and energetic basis of folded protein transport by the FimD usher

D. Baker, G. Waksman, S. Hultgren, 2013, Nature.

The structure of myristoyl-CoA:protein N-myristoyltransferase.

J. Gordon, G. Waksman, K. Fütterer, 1999, Biochimica et biophysica acta.

VirB2 and VirB5 proteins: specialized adhesins in bacterial type-IV secretion systems?

G. Waksman, R. Fronzes, S. Backert, 2008, Trends in microbiology.

Suppression of type 1 pilus assembly in uropathogenic Escherichia coli by chemical inhibition of subunit polymerization

G. Waksman, P. Gane, A. Lo, 2013, The Journal of antimicrobial chemotherapy.

Crystal structure of the phosphotyrosine recognition domain SH2 of the Src oncogene product complexed with tyrosine-phosphorylated peptides.

G. Waksman, 1994, Cellular and molecular biology.

Structure–function analysis reveals that the Pseudomonas aeruginosa Tps4 two-partner secretion system is involved in CupB5 translocation

P. Simpson, G. Waksman, A. Busch, 2015, Protein science : a publication of the Protein Society.

Pre-steady-state kinetic studies of Saccharomyces cerevisiae myristoylCoA:protein N-myristoyltransferase mutants identify residues involved in catalysis.

J. Gordon, G. Waksman, T. Farazi, 2001, Biochemistry.

Type IV secretion systems: versatility and diversity in function

K. Walldén, G. Waksman, Á. Rivera-Calzada, 2010, Cellular microbiology.

Pili and flagella biology, structure, and biotechnological applications.

G. Waksman, H. Remaut, Nani van Gerven, 2011, Progress in molecular biology and translational science.

Effective assembly of fimbriae in Escherichia coli depends on the translocation assembly module nanomachine

G. Waksman, T. Lithgow, A. Lo, 2016, Nature Microbiology.

Structural Basis for the Differential Binding Affinities of the HsfBD1 and HsfBD2 Domains in the Haemophilus influenzae Hsf Adhesin

G. Waksman, G. Meng, J. S. St. Geme, 2009, Journal of bacteriology.

The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation

P. Cossart, G. Waksman, A. Williams, 2019, Nature Communications.

Reconstitution of a minimal machinery capable of assembling type IV pili 1 2

G. Waksman, A. Busch, K. Forest, 2017 .

Structures of Saccharomyces cerevisiae N-myristoyltransferase with bound myristoylCoA and peptide provide insights about substrate recognition and catalysis.

G. Waksman, T. Farazi, J. Gordon, 2001, Biochemistry.

The crystal structure of a partial mouse Notch‐1 ankyrin domain: Repeats 4 through 7 preserve an ankyrin fold

G. Waksman, Raphael Kopan, O. Lubman, 2005, Protein science : a publication of the Protein Society.

Purification of the beta-glucosidase from Sclerotinia sclerotiorum.

G. Waksman, 1988, Biochimica et biophysica acta.

SnapShot: Bacterial Appendages II

A. T. Rêgo, G. Waksman, R. Fronzes, 2010, Cell.

CRYSTAL-STRUCTURE OF THE PHOSPHOTYROSINE RECOGNITION DOMAIN (SH2) OF THE V-SRC TYROSINE KINASE COMPLEXED WITH TYROSINE PHOSPHORYLATED PEPTIDES

J. Kuriyan, G. Waksman, D. Kominos, 1993 .

Common amino acid domain among endopolygalacturonases of ascomycete fungi

G. Waksman, J. Keon, 1990, Applied and environmental microbiology.

The Cryoelectron Microscopy Structure of the Type 1 Chaperone-Usher Pilus Rod

R. Glockshuber, G. Waksman, Tiago R D Costa, 2017, bioRxiv.

Comparison of the ion channel characteristics of proapoptotic BAX and antiapoptotic BCL-2.

G Waksman, S. Korsmeyer, G. Waksman, 1997, Proceedings of the National Academy of Sciences of the United States of America.

Crystal structure of the MrkD1P receptor binding domain of Klebsiella pneumoniae and identification of the human collagen V binding interface

A. T. Rêgo, G. Waksman, S. Geibel, 2012, Molecular microbiology.

Structural biology of protein complexes

G. Waksman, 2005 .

Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis.

J. Kuriyan, G. Waksman, C. Williams, 1994, Journal of molecular biology.

Bacterial DNA Polymerase I

G. Waksman, W. Allen, Ying Li, 2010 .

Purification and characterization of two endopolygalacturonases from Sclerotinia sclerotiorum.

G. Waksman, G. Turner, J. Keon, 1991, Biochimica et biophysica acta.

Tunable reagents for multi-functional bioconjugation: reversible or permanent chemical modification of proteins and peptides by control of maleimide hydrolysis† †Electronic supplementary information (ESI) available: Full experimental details and characterisation. See DOI: 10.1039/c1cc11114k Click he

James R. Baker, Gabriel Waksman, Finn Werner, 2011, Chemical communications.

Protein Modification, Bioconjugation, and Disulfide Bridging Using Bromomaleimides

James R. Baker, Gabriel Waksman, Mark E. B. Smith, 2010, Journal of the American Chemical Society.

Crystal structures of open and closed forms of binary and ternary complexes of the large fragment of Thermus aquaticus DNA polymerase I: structural basis for nucleotide incorporation

Gabriel Waksman, Ying Li, G. Waksman, 1998, The EMBO journal.

Investigation of phosphotyrosine recognition by the SH2 domain of the Src kinase.

J. M. Bradshaw, G Waksman, G. Waksman, 1999, Journal of molecular biology.

Virulence‐targeted Antibacterials: Concept, Promise, and Susceptibility to Resistance Mechanisms

G. Waksman, D. Steadman, H. Remaut, 2015, Chemical biology & drug design.

Chaperone–usher pathways: diversity and pilus assembly mechanism

G. Waksman, A. Busch, 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

Proteomics and Protein-Protein Interactions

Gabriel Waksman, G. Waksman, 2005 .

Introduction: Proteomics and Protein-Protein Interactions: Biology, Chemistry, Bioinformatics, and Drug Design

Gabriel Waksman, Clare Sansom, G. Waksman, 2005 .

Crystal structures of the Klenow fragment of Thermus aquaticus DNA polymerase I complexed with deoxyribonucleoside triphosphates

G. Waksman, S. Korolev, Ying Li, 1998, Protein science : a publication of the Protein Society.

Hemibiotrophic infection of Pisum sativum by Colletotrichum truncatum

G. Waksman, R. O’Connell, J. A. Bailey, 1993 .

Two-step and one-step secretion mechanisms in Gram-negative bacteria: contrasting the type IV secretion system and the chaperone-usher pathway of pilus biogenesis.

A. T. Rêgo, G. Waksman, V. Chandran, 2010, The Biochemical journal.

Supraomohyoid neck dissection in the treatment of head and neck tumors. Survival results in 212 cases.

G. Waksman, L. Kowalski, H. Torloni, 1993, Archives of otolaryngology--head & neck surgery.

The structural biology of type IV secretion systems

G. Waksman, R. Fronzes, P. Christie, 2009, Nature Reviews Microbiology.

Type IV secretion machinery

G. Schröder, S. Savvides, G. Waksman, 2005 .

FGF binding and FGF receptor activation by synthetic heparan-derived di- and trisaccharides.

G. Waksman, A. Herr, D. Ornitz, 1995, Science.

Motions of the fingers subdomain of klentaq1 are fast and not rate limiting: implications for the molecular basis of fidelity in DNA polymerases.

G. Waksman, P. Rothwell, V. Mitaksov, 2005, Molecular cell.

Crystal structure of the FimD usher bound to its cognate FimC:FimH substrate

Gabriel Waksman, Tao Wang, Huilin Li, 2011, Nature.

Structural basis for host recognition by the Haemophilus influenzae Hia autotransporter

G. Waksman, J. S. St. Geme, T. Juehne, 2004, The EMBO journal.

Phage P4 origin‐binding domain structure reveals a mechanism for regulation of DNA‐binding activity by homo‐ and heterodimerization of winged helix proteins

G. Waksman, S. Korolev, E. Lanka, 2002, Molecular microbiology.

Supplemental Data Crystal Structure of a vFlip-IKK γ Complex : Insights into Viral Activation of the IKK Signalosome

Gabriel Waksman, Claire Bagnéris, C. Boshoff, 2008 .

Molecular recognition by SH2 domains.

Gabriel Waksman, J. M. Bradshaw, G. Waksman, 2002, Advances in protein chemistry.

SH2 domains: From structure to energetics, a dual approach to the study of structure–function relationships

J. M. Bradshaw, J. Bradshaw, G. Waksman, 1999, Medicinal research reviews.

Structure of the DNA binding domain of E. coli SSB bound to ssDNA

G. Waksman, A. Kozlov, T. Lohman, 2000, Nature Structural Biology.

Architecture of the Helicobacter pylori Cag‐type IV secretion system

G. Waksman, L. Terradot, 2011, The FEBS journal.

Structural basis of tropism of Escherichia coli to the bladder during urinary tract infection

G. Waksman, S. Langermann, J. Pinkner, 2002, Molecular microbiology.

Protein–protein interaction through β-strand addition

Gabriel Waksman, Han Remaut, G. Waksman, 2006 .

BH3 Domain of BAD Is Required for Heterodimerization with BCL-XL and Pro-apoptotic Activity*

S. Korsmeyer, G. Waksman, J. Zha, 1997, The Journal of Biological Chemistry.

Hematopoietic malignancies demonstrate loss-of-function mutations of BAX.

S. Korsmeyer, G. Waksman, J. Meijerink, 1998, Blood.

Rotations of the 2B sub-domain of E. coli UvrD helicase/translocase coupled to nucleotide and DNA binding.

T. Ha, G. Waksman, T. Lohman, 2011, Journal of molecular biology.

Rotations of the 2 B Subdomain of E . coli UvrD Helicase / Translocase Coupled to Nucleotide and DNA Binding

T. Ha, G. Waksman, T. Lohman, 2011 .

DNA helicases, motors that move along nucleic acids: Lessons from the SF1 helicase superfamily

G. Waksman, T. Lohman, C. J. Fischer, 2003 .

The 2B domain of the Escherichia coli Rep protein is not required for DNA helicase activity

G. Waksman, T. Lohman, S. Korolev, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Helicases as nucleic acid unwinding machines

G. Waksman, J. Carazo, E. Lanka, 2000, Nature Structural Biology.

Major Domain Swiveling Revealed by the Crystal Structures of Complexes of E. coli Rep Helicase Bound to Single-Stranded DNA and ADP

Gabriel Waksman, G. Waksman, T. Lohman, 1997, Cell.

Use of chimeric type IV secretion systems to define contributions of outer membrane subassemblies for contact‐dependent translocation

E. Orlova, Christian González-Rivera, G. Waksman, 2017, Molecular microbiology.

Structure of a type IV secretion system

E. Orlova, G. Waksman, R. Fronzes, 2014, Nature.

TraG-Like Proteins of DNA Transfer Systems and of the Helicobacter pylori Type IV Secretion System: Inner Membrane Gate for Exported Substrates?

Gabriel Waksman, Rudi Lurz, G. Schröder, 2002, Journal of bacteriology.

Crystal structure of the homo-tetrameric DNA binding domain of Escherichia coli single-stranded DNA-binding protein determined by multiwavelength x-ray diffraction on the selenomethionyl protein at 2.9-A resolution.

G. Waksman, T. Lohman, C. S. Ricard, 1997, Proceedings of the National Academy of Sciences of the United States of America.

VirB11 ATPases are dynamic hexameric assemblies: new insights into bacterial type IV secretion

S. Savvides, G. Waksman, R. Lurz, 2003, The EMBO journal.

Loss of fibroblast growth factor receptor 2 ligand-binding specificity in Apert syndrome.

G. Waksman, A. Herr, D. Ornitz, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structure of a Type IV Secretion System Core Complex

E. Orlova, H. Saibil, G. Waksman, 2009, Science.

Regulation of antigen receptor function by protein tyrosine kinases.

G. Waksman, K. Fütterer, A. Chan, 1999, Progress in biophysics and molecular biology.

Mutational investigation of the specificity determining region of the Src SH2 domain.

J. M. Bradshaw, G Waksman, G. Waksman, 2000, Journal of molecular biology.

Semisynthetic Src SH2 domains demonstrate altered phosphopeptide specificity induced by incorporation of unnatural lysine derivatives.

G. Waksman, D. Macmillan, S. Virdee, 2010, Chemistry & biology.

Structure of the Bacterial Sex F Pilus Reveals an Assembly of a Stoichiometric Protein-Phospholipid Complex

Terry K. Smith, G. Waksman, E. Egelman, 2016, Cell.

Structure of a VirD4 coupling protein bound to a VirB type IV secretion machinery

E. Orlova, G. Waksman, K. Thalassinos, 2017, The EMBO journal.

A comprehensive guide to pilus biogenesis in Gram-negative bacteria

G. Waksman, M. Hospenthal, Tiago R. D. Costa, 2017, Nature Reviews Microbiology.

Crystal structure of the Haemophilus influenzae Hap adhesin reveals an intercellular oligomerization mechanism for bacterial aggregation

G. Waksman, G. Meng, J. S. St. Geme, 2011, The EMBO journal.

Repetitive Architecture of the Haemophilus influenzae Hia Trimeric Autotransporter

G. Waksman, G. Meng, J. S. St. Geme, 2008, Journal of molecular biology.

Structural biology of the Gram-negative bacterial conjugation systems.

G. Waksman, A. Ilangovan, S. Connery, 2015, Trends in microbiology.

Structure of a Chaperone-Usher Pilus Reveals the Molecular Basis of Rod Uncoiling

G. Waksman, E. Egelman, S. Hultgren, 2016, Cell.

Structure of a bacterial type IV secretion core complex at subnanometre resolution

E. Orlova, G. Waksman, E. Pardon, 2013, The EMBO journal.

Structural analysis of the Saf pilus by electron microscopy and image processing.

E. Orlova, G. Waksman, H. Remaut, 2008, Journal of Molecular Biology.

Structural and functional characterization of the VirB5 protein from the type IV secretion system encoded by the conjugative plasmid pKM101

G. Waksman, C. Baron, Q. Yuan, 2003, Proceedings of the National Academy of Sciences of the United States of America.

The C‐terminal domain of full‐length E. coli SSB is disordered even when bound to DNA

S. Savvides, G. Waksman, A. Kozlov, 2004, Protein science : a publication of the Protein Society.

Molecular cloning of genes expressed specifically during induction of cell wall degrading enzymes from Sclerotinia sclerotiorum and preliminary identification of a fungal beta-galactosidase encoding gene by expression in Escherichia coli

G. Waksman, 1988, Current Genetics.

Crystal structure of enteropeptidase light chain complexed with an analog of the trypsinogen activation peptide.

G Waksman, G. Waksman, K. Fütterer, 1999, Journal of molecular biology.

Probing a cell-embedded megadalton protein complex by DNP-supported solid-state NMR

G. Waksman, G. Folkers, A. Bonvin, 2015, Nature Methods.

Structure and mechanism of DNA polymerases.

Gabriel Waksman, Paul J Rothwell, G. Waksman, 2005, Advances in protein chemistry.

THE Ion GENE AND PHOTOPROTECTION IN Escherichia coli K‐12

G. Waksman, A. Favre, G. Thomas, 1984, Photochemistry and photobiology.

Molecular architecture of bacterial type IV secretion systems.

G. Waksman, R. Fronzes, 2010, Trends in biochemical sciences.

Identification, structure and mode of action of a new regulator of the Helicobacter pylori HP0525 ATPase

G. Waksman, R. Bayliss, R. Haas, 2007, The EMBO journal.

Unveiling Molecular Scaffolds of the Type IV Secretion System

G. Waksman, H. Yeo, 2004, Journal of bacteriology.

Unveiling molecular scaffold s of the type IV secretion system

G. Waksman, H. Yeo, 2004 .

Crystal structure of the hexameric traffic ATPase of the Helicobacter pylori type IV secretion system.

S. Savvides, G. Waksman, A. Herr, 2000, Molecular cell.

Agrobacterium VirB10 domain requirements for type IV secretion and T pilus biogenesis

G. Waksman, R. Bayliss, P. Christie, 2009, Molecular microbiology.

Chaperone-assisted pilus assembly and bacterial attachment.

G Waksman, G. Waksman, D. Choudhury, 2000, Current opinion in structural biology.

Structural basis for Syk tyrosine kinase ubiquity in signal transduction pathways revealed by the crystal structure of its regulatory SH2 domains bound to a dually phosphorylated ITAM peptide.

G Waksman, G. Waksman, R. Grucza, 1998, Journal of molecular biology.

Structure of the VirB4 ATPase, alone and bound to the core complex of a type IV secretion system

K. Walldén, E. Orlova, G. Waksman, 2012, Proceedings of the National Academy of Sciences.

Structural Determinants of Autoproteolysis of the Haemophilus influenzae Hap Autotransporter

G. Waksman, H. Erickson, D. Fink, 2009, Infection and Immunity.

Effective assembly of bacterial fimbriae depends on the TAM nanomachine

G. Waksman, T. Lithgow, A. Lo, 2017 .

PapD-like chaperones provide the missing information for folding of pilin proteins.

G. Waksman, S. Langermann, J. Pinkner, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Biogenesis and adhesion of type 1 and P pili.

G. Waksman, S. Geibel, James Lillington, 2014, Biochimica et biophysica acta.

Comparisons between the structures of HCV and Rep helicases reveal structural similarities between SF1 and SF2 super‐families of helicases

G. Waksman, P. Weber, T. Lohman, 1998, Protein science : a publication of the Protein Society.

helicases ofreveal structural similarities between SF 1 and SF 2 superfamilies Comparisons between the structures of HCV and Rep helicases

G. Waksman, P. Weber, T. Lohman, 1997 .

Crystal structure of the large fragment of Thermus aquaticus DNA polymerase I at 2.5-A resolution: structural basis for thermostability.

M. Nayal, G. Waksman, E. Di Cera, 1995, Proceedings of the National Academy of Sciences of the United States of America.

2- and 3-substituted imidazo[1,2-a]pyrazines as inhibitors of bacterial type IV secretion

K. Walldén, G. Waksman, P. Gane, 2014, Bioorganic & medicinal chemistry.

Crystal structure of the Legionella effector WipA

G. Waksman, N. Pinotsis, 2017 .

Structure of the WipA protein reveals a novel tyrosine protein phosphatase effector from Legionella pneumophila

G. Waksman, N. Pinotsis, 2017, The Journal of Biological Chemistry.

Structural biology of bacterial secretion systems in gram-negative pathogens--potential for new drug targets.

A. T. Rêgo, G Waksman, G. Waksman, 2009, Infectious disorders drug targets.

Molecular basis of usher pore gating in Escherichia coli pilus biogenesis

G. Waksman, J. Pinkner, S. Hultgren, 2013, Proceedings of the National Academy of Sciences.

Structural biology of the chaperone–usher pathway of pilus biogenesis

G. Waksman, S. Hultgren, 2009, Nature Reviews Microbiology.

An intramolecular FRET system monitors fingers subdomain opening in Klentaq1

G. Waksman, P. Rothwell, W. Allen, 2008, Protein science : a publication of the Protein Society.

Crystal structures of a ddATP‐, ddTTP‐, ddCTP, and ddGTP‐ trapped ternary complex of Klentaq1: Insights into nucleotide incorporation and selectivity

G. Waksman, Ying Li, 2001, Protein science : a publication of the Protein Society.

Structural and biophysical investigation of the interaction of a mutant Grb2 SH2 domain (W121G) with its cognate phosphopeptide

G. Waksman, S. Geibel, M. Kunze, 2016, Protein science : a publication of the Protein Society.

The Role of Water in Computational and Experimental Derivation of Binding Thermodynamics in SH2 Domains

G. Waksman, S. Geroult, S. Virdee, 2006, Chemical biology & drug design.

Structure and specificity of the SH2 domain

J. Kuriyan, G. Waksman, 2004, Cell.

Structural and thermodynamic basis for the interaction of the Src SH2 domain with the activated form of the PDGF beta-receptor.

Gabriel Waksman, G. Waksman, O. Lubman, 2003, Journal of molecular biology.

Dissection of the energetic coupling across the Src SH2 domain-tyrosyl phosphopeptide interface.

G. Waksman, O. Lubman, 2002, Journal of molecular biology.

pH‐Dependent self‐association of the Src homology 2 (SH2) domain of the Src homologous and collagen‐like (SHC) protein

G. Waksman, R. Grucza, K. Fütterer, 1996, Protein science : a publication of the Protein Society.

Calorimetric examination of high-affinity Src SH2 domain-tyrosyl phosphopeptide binding: dissection of the phosphopeptide sequence specificity and coupling energetics.

J. M. Bradshaw, G Waksman, G. Waksman, 1999, Biochemistry.

Donor-strand exchange in chaperone-assisted pilus assembly revealed in atomic detail by molecular dynamics.

S. Radford, E. Paci, G. Waksman, 2008, Journal of molecular biology.

Donor-strand exchange in chaperone-assisted pilus assembly proceeds through a concerted beta strand displacement mechanism.

S. Radford, G. Waksman, S. Hultgren, 2006, Molecular cell.

Structure-based design of Taq DNA polymerases with improved properties of dideoxynucleotide incorporation.

G. Waksman, Y. Li, V. Mitaxov, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Chaperone Priming of Pilus Subunits Facilitates a Topological Transition that Drives Fiber Formation

G. Waksman, J. Pinkner, S. Hultgren, 2002, Cell.

Structural biology of periplasmic chaperones.

G. Waksman, G. Phan, W. Allen, 2009, Advances in protein chemistry and structural biology.

Crystallographic phasing of myristoyl-CoA-protein N-myristoyltransferase using an iodinated analog of myristoyl-CoA.

G. Gokel, J. Gordon, G. Waksman, 2001, Acta crystallographica. Section D, Biological crystallography.

Bacterial secretion comes of age

G. Waksman, 2012, Philosophical Transactions of the Royal Society B: Biological Sciences.

Fiber assembly by the chaperone-usher pathway.

G. Waksman, S. Hultgren, F. G. Sauer, 2004, Biochimica et biophysica acta.

Pilus biogenesis at the inner and outer membranes of Gram-negative bacteria

G. Waksman, M. Hospenthal, Tiago R. D. Costa, 2017 .

Cryo-EM structure of the bacteria killing type IV secretion system core complex from Xanthomonas citri

G. Waksman, R. Portugal, A. Cassago, 2018, Nature Microbiology.

Structural Determinants of Haemophilus influenzae Adherence to Host Epithelia: Variations on Type V Secretion

G. Waksman, J. W. Geme, H. Yeo, 2005 .

Architectures and biogenesis of non-flagellar protein appendages in Gram-negative bacteria

G. Waksman, R. Fronzes, H. Remaut, 2008, The EMBO journal.

Mechanism of effector capture and delivery by the type IV secretion system from Legionella pneumophila

G. Waksman, C. Roy, A. Meir, 2020, Nature Communications.

A large domain swap in the VirB11 ATPase of Brucella suis leaves the hexameric assembly intact.

G. Waksman, C. Baron, R. Bayliss, 2006, Journal of molecular biology.

Pilus biogenesis at the outer membrane of Gram-negative bacterial pathogens.

G. Waksman, G. Phan, W. Allen, 2012, Current opinion in structural biology.

Structural biology of bacterial pathogenesis.

G. Waksman, H. Remaut, 2004, Current Opinion in Structural Biology.

Crystal Structure of the Anticoagulant Slow Form of Thrombin*

S. Savvides, G. Waksman, E. Di Cera, 2002, The Journal of Biological Chemistry.

Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug

A. T. Rêgo, G. Waksman, J. Pinkner, 2010, Journal of bacteriology.

Role of electrostatic interactions in SH2 domain recognition: salt-dependence of tyrosyl-phosphorylated peptide binding to the tandem SH2 domain of the Syk kinase and the single SH2 domain of the Src kinase.

J. M. Bradshaw, G. Waksman, R. Grucza, 2000, Biochemistry.

Structural and Functional Characterization of Pseudomonas aeruginosa CupB Chaperones

G. Waksman, A. Filloux, G. Meng, 2011, PloS one.

Ordered and Ushered; the Assembly and Translocation of the Adhesive Type I and P Pili

G. Waksman, James Lillington, 2013, Biology.

Heparin-induced Self-association of Fibroblast Growth Factor-2

G. Waksman, R. Sasisekharan, A. Herr, 1997, The Journal of Biological Chemistry.

Synthetic protein transduction domains: enhanced transduction potential in vitro and in vivo.

G. Waksman, S. Schwarze, A. Ho, 2001, Cancer research.

Structural Basis of the Interaction of the Pyelonephritic E. coli Adhesin to Its Human Kidney Receptor

G. Waksman, J. Pinkner, S. Hultgren, 2001, Cell.

Proteins DotY and DotZ modulate the dynamics and localization of the type IVB coupling complex of Legionella pneumophila

G. Waksman, C. Roy, A. Meir, 2021, Molecular microbiology.

Translocation through the Conjugative Type IV Secretion System Requires Unfolding of Its Protein Substrate

G. Waksman, Martina Trokter, 2018, Journal of bacteriology.

Structural studies of T4S systems by electron microscopy

E. Orlova, G. Waksman, Adam Redzej, 2015 .

Structural organisation of the type IV secretion systems☆

E. Orlova, G. Waksman, 2014, Current opinion in microbiology.

Mass spectrometric and thermodynamic studies reveal the role of water molecules in complexes formed between SH2 domains and tyrosyl phosphopeptides.

J. M. Bradshaw, G Waksman, M. Zvelebil, 1998, Structure.

The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation

P. Cossart, G. Waksman, A. Williams, 2019, Nature Communications.

Calorimetric and structural studies of 1,2,3-trisubstituted cyclopropanes as conformationally constrained peptide inhibitors of Src SH2 domain binding.

Gabriel Waksman, G. Waksman, O. Lubman, 2002, Journal of the American Chemical Society.

The Remarkable Biomechanical Properties of the Type 1 Chaperone-Usher Pilus: A Structural and Molecular Perspective

G. Waksman, M. Hospenthal, 2019, Microbiology spectrum.

Unexpected crucial role of residue 225 in serine proteases.

G Waksman, G. Waksman, E. Di Cera, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Structural and Molecular Biology of a Protein-Polymerizing Nanomachine for Pilus Biogenesis.

G. Waksman, 2017, Journal of molecular biology.

dNTP-dependent Conformational Transitions in the Fingers Subdomain of Klentaq1 DNA Polymerase

C. Seidel, G. Waksman, E. Sisamakis, 2013, The Journal of Biological Chemistry.

A Pre-equilibrium before Nucleotide Binding Limits Fingers Subdomain Closure by Klentaq1*♦

G. Waksman, P. Rothwell, 2007, Journal of Biological Chemistry.

Structural Studies of the Klentaq1 DNA Polymerase

G. Waksman, Ying Li, 2001 .

The tandem Src homology 2 domain of the Syk kinase: A molecular device that adapts to interphosphotyrosine distances

G. Waksman, R. Grucza, S. Kumaran, 2003, Proceedings of the National Academy of Sciences of the United States of America.

Going round in circles: the structural biology of type III secretion systems

G. Waksman, 2009, Nature Structural &Molecular Biology.

The Structure of the PapD-PapGII Pilin Complex Reveals an Open and Flexible P5 Pocket

G. Waksman, J. Pinkner, S. Hultgren, 2012, Journal of bacteriology.

Protein-protein interaction through beta-strand addition.

Gabriel Waksman, Han Remaut, G. Waksman, 2006, Trends in biochemical sciences.

Fiber Formation across the Bacterial Outer Membrane by the Chaperone/Usher Pathway

Tao Wang, Gabriel Waksman, Huilin Li, 2008, Cell.

Design, synthesis, and evaluation of peptide‐imidazo[1,2‐a]pyrazine bioconjugates as potential bivalent inhibitors of the VirB11 ATPase HP0525

K. Walldén, G. Waksman, P. Gane, 2021, Journal of peptide science : an official publication of the European Peptide Society.

Thermodynamic study of the binding of the tandem-SH2 domain of the Syk kinase to a dually phosphorylated ITAM peptide: evidence for two conformers.

G. Waksman, R. Grucza, K. Fütterer, 1999, Biochemistry.

Substrate recruitment mechanism by gram-negative type III, IV, and VI bacterial injectisomes.

G. Waksman, A. Meir, K. Macé, 2023, Trends in microbiology.

Structure of a translocation signal domain mediating conjugative transfer by type IV secretion systems

M. Topf, G. Waksman, K. Zangger, 2013, Molecular microbiology.

BIROn - Birkbeck Institutional Research Online Translocation through the conjugative Type system requires of its protein

G. Waksman, Martina Trokter, 2021 .

Calorimetric investigation of proton linkage by monitoring both the enthalpy and association constant of binding: application to the interaction of the Src SH2 domain with a high-affinity tyrosyl phosphopeptide.

J. M. Bradshaw, G Waksman, G. Waksman, 1998, Biochemistry.

X‐ray crystal structures of the type IVb secretion system DotB ATPases

G. Waksman, M. Prevost, 2018, Protein science : a publication of the Protein Society.

Molecular mechanism of bacterial type 1 and P pili assembly

G. Waksman, G. Phan, A. Busch, 2015, Philosophical Transactions of the Royal Society A: Mathematical, Physical and Engineering Sciences.

The Role of Chaperone-subunit Usher Domain Interactions in the Mechanism of Bacterial Pilus Biogenesis Revealed by ESI-MS*

S. Radford, G. Waksman, G. Phan, 2012, Molecular & Cellular Proteomics.

CRYSTAL-STRUCTURES OF PEPTIDE COMPLEXES OF SH2 DOMAINS

Gabriel Waksman, John Kuriyan, Ch Lee, 1994 .

Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

G. Waksman, C. Roy, A. Meir, 2018, Nature Communications.

The Legionella effector WipB is a translocated Ser/Thr phosphatase that targets the host lysosomal nutrient sensing machinery

G. Waksman, N. Pinotsis, M. Prevost, 2017, Scientific Reports.

Bacterial surface appendages as targets for novel antibacterial therapeutics.

G. Waksman, A. Lo, D. Steadman, 2014, Future microbiology.

The Anticoagulant Thrombin Mutant W215A/E217A Has a Collapsed Primary Specificity Pocket*

S. Savvides, G. Waksman, E. Di Cera, 2004, Journal of Biological Chemistry.

SH2 Domains: From Structure to Energetics, a Dual Approach to the Study of Structure—Function Relationships

J. M. Bradshaw, G. Waksman, R. Grucza, 1999 .

Dissection of Pilus Tip Assembly by the FimD Usher Monomer

G. Waksman, S. Hultgren, G. Phan, 2013, Journal of molecular biology.

Crystal Structure of the P Pilus Rod Subunit PapA

G. Waksman, S. Hultgren, E. Bullitt, 2007, PLoS pathogens.

Molecular mechanism of P pilus termination in uropathogenic Escherichia coli

G. Waksman, S. Hultgren, H. Remaut, 2006, EMBO reports.

Drosophila rab GDI mutants disrupt development but have normal rab membrane extraction

G. Waksman, P. Stahl, M. Barbieri, 2001, Genesis.

SH2 domains: role, structure and implications for molecular medicine

Gabriel Waksman, G. Waksman, S. Kumaran, 2004, Expert Reviews in Molecular Medicine.

Type IV secretion systems: versatility and diversity in function

K. Walldén, G. Waksman, Á. Rivera-Calzada, 2010, Cellular microbiology.

Structured and disordered facets of the GPCR fold.

Tilman Flock, Julian Gough, Matt E. Oates, 2014, Current opinion in structural biology.

Reprint of "Biogenesis and adhesion of type 1 and P pili".

G. Waksman, S. Geibel, James Lillington, 2015, Biochimica et biophysica acta.

Legionella DotM structure reveals a role in effector recruiting to the Type 4B secretion system

G. Waksman, C. Roy, A. Meir, 2018, Nature Communications.

Domain activities of PapC usher reveal the mechanism of action of an Escherichia coli molecular machine

G. Waksman, J. Pinkner, S. Hultgren, 2012, Proceedings of the National Academy of Sciences.

NMR structure of a complex between the VirB9/VirB7 interaction domains of the pKM101 type IV secretion system

G. Waksman, P. Driscoll, R. Bayliss, 2007, Proceedings of the National Academy of Sciences.

Correction: Allosteric signalling in the outer membrane translocation domain of PapC usher

M. Topf, G. Waksman, Irene Farabella, 2016, eLife.

Protein-Injection Machines in Bacteria

G. Waksman, J. Galán, 2018, Cell.

Allosteric signalling in the outer membrane translocation domain of PapC usher

M. Topf, G. Waksman, Irene Farabella, 2014, eLife.

Structural and functional diversity of type IV secretion systems.

G. Waksman, P. Christie, K. Macé, 2023, Nature reviews. Microbiology.

Resonance Assignments of the Complex between TraN and the C-terminal Domain of TraO from the Conjugative Plasmid pKM101

G. Waksman, P. Driscoll, R. Bayliss, 2006, Journal of biomolecular NMR.

Bacterial surface appendages as targets for novel antibacterial therapeutics.

G. Waksman, A. Lo, D. Steadman, 2014, Future microbiology.

Second Order Rate Constants of Donor-Strand Exchange Reveal Individual Amino Acid Residues Important in Determining the Subunit Specificity of Pilus Biogenesis

S. Radford, G. Waksman, G. Phan, 2011, Journal of the American Society for Mass Spectrometry.

The molecular dissection of the chaperone-usher pathway.

G. Waksman, S. Geibel, 2014, Biochimica et biophysica acta.

Structural Homology between the C-Terminal Domain of the PapC Usher and Its Plug

A. T. Rêgo, G. Waksman, J. Pinkner, 2010, Journal of bacteriology.

Pocket Complex Reveals an Open and Flexible P 5 The Structure of the PapD-PapGII Pilin

G. Waksman, J. Pinkner, K. Dodson, 2012 .

Crystallography and electron microscopy of chaperone/usher pilus systems.

G. Waksman, S. Geibel, 2011, Advances in experimental medicine and biology.

Sugar Recognition and Bacterial Attachment

G. Waksman, S. Hultgren, K. Dodson, 2005 .

The Chaperone-Usher Pathway of Pilus Fiber Biogenesis

G. Waksman, S. Hultgren, F. G. Sauer, 2005 .

Rapid, Accurate, and Precise Calculation of Relative Binding Affinities for the SH2 Domain Using a Computational Grid.

Shantenu Jha, Peter V Coveney, Gabriel Waksman, 2007, Journal of chemical theory and computation.

Gate for Exported Substrates ? Type IV Secretion System : Inner Membrane Helicobacter pylori Systems and of the TraG-Like Proteins of DNA Transfer

G. Schröder, G. Waksman, R. Lurz, 2002 .

Prediction of Solvation Sites at the Interface of Src SH2 Domain Complexes Using Molecular Dynamics Simulations

Gabriel Waksman, Satpal Virdee, Manisha Hooda, 2007, Chemical biology & drug design.