Z. Ni

发表

A high-density screening format for encoded combinatorial libraries: assay miniaturization and its application to enzymatic reactions.

J. Schullek, J. H. Butler, Z. Ni, 1997, Analytical biochemistry.

Versatile approach to encoding combinatorial organic syntheses using chemically robust secondary amine tags.

C. Holmes, Z. Ni, E. Gordon, 1996, Journal of medicinal chemistry.

Encoded combinatorial chemistry: synthesis and screening of a library of highly functionalized pyrrolidines.

J. Schullek, Z. Ni, E. Gordon, 1997, Proceedings of the National Academy of Sciences of the United States of America.

4-(Aminoalkylamino)-3-benzimidazole-quinolinones as potent CHK-1 inhibitors.

Z. Ni, D. Bussiere, S. Ramurthy, 2006, Bioorganic & medicinal chemistry letters.

Imidazo[1,2-a]pyridin-6-yl-benzamide analogs as potent RAF inhibitors.

K. Shoemaker, Z. Ni, S. Cowan-Jacob, 2017, Bioorganic & medicinal chemistry letters.

Synthesis, Binding Mode, and Antihyperglycemic Activity of Potent and Selective (5-Imidazol-2-yl-4-phenylpyrimidin-2-yl)[2-(2-pyridylamino)ethyl]amine Inhibitors of Glycogen Synthase Kinase 3.

Sean P. Brown, Kirk W. Johnson, Z. Ni, 2017, Journal of medicinal chemistry.

Synthesis of new acylsulfamoyl benzoxaboroles as potent inhibitors of HCV NS3 protease.

Z. Ni, Suoming Zhang, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and evaluation of novel alpha-amino cyclic boronates as inhibitors of HCV NS3 protease.

Z. Ni, P. Rowland, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

Synthesis and biological evaluations of P4-benzoxaborole-substituted macrocyclic inhibitors of HCV NS3 protease.

Z. Ni, Suoming Zhang, S. Baker, 2010, Bioorganic & medicinal chemistry letters.

The discovery of tetrahydro-beta-carbolines as inhibitors of the kinesin Eg5.

Z. Ni, E. Martin, D. Bussiere, 2012, Bioorganic & medicinal chemistry letters.

Progress and development of small molecule HCV antivirals.

Z. Ni, A. Wagman, 2004, Current opinion in drug discovery & development.

Toward Orally Absorbed Prodrugs of the Antibiotic Aztreonam. Design of Novel Prodrugs of Sulfate Containing Drugs. Part 2.

Z. Ni, E. Gordon, M. Duncton, 2020, ACS medicinal chemistry letters.

Carbene-Catalyzed Formal [3+3] Cycloaddition Reaction for Access to Substituted 2-Phenylbenzothiazoles

Z. Ni, Song Yang, Zhichao Jin, 2020 .

Identification of NVP-BKM120 as a Potent, Selective, Orally Bioavailable Class I PI3 Kinase Inhibitor for Treating Cancer.

Simon Ng, Yanchen Zhang, Kenneth Crawford, 2011, ACS medicinal chemistry letters.

Transition-Metal-Mediated C-S Bond Cleavage Reactions

Z. Ni, T. Luh, 1990 .

Nickel‐Catalyzed Silylolefination of Allylic Dithioacetals: (E,E)‐Trimethyl(4‐Phenyl‐1,3‐Butadienyl)Silane

Z. Ni, T. Luh, 2003 .

Transition metal promoted reaction. 34. Unified synthesis of vinylsilanes and silylated butadienes. Nickel-catalyzed olefination and silylolefination of dithioacetals

Z. Ni, Y. Tzeng, T. Luh, 1990 .

Actinonin, a naturally occurring antibacterial agent, is a potent deformylase inhibitor.

Z. Ni, D. Chen, Z. Yuan, 2000, Biochemistry.

Glycopeptides semi-synthetiques a base de desmethyle-vancomycine a action antibiotique

Z. Ni, Yaohui Lei, John Jian-Xin Wang, 2006 .

The effect of the ring size of the dithiolato leaving group on the orientation of β-elimination in the nickel-catalysed alkenation of cyclic dithioacetals with Me2SiCH2MgCl

Z. Ni, Ken‐Tsung Wong, T. Luh, 1991 .

Transition-metal-promoted reactions. 25. Regioselective silylolefination of allylic dithioacetals. Stereoselective synthesis of 1-(trimethylsilyl)butadienes

Z. Ni, T. Luh, 1988 .

Encoded combinatorial chemistry: binary coding using chemically robust secondary amine tags.

C. Holmes, Z. Ni, M. Gallop, 1996, Methods in enzymology.

Synthesis and SAR of acyclic HCV NS3 protease inhibitors with novel P4-benzoxaborole moieties.

Z. Ni, Suoming Zhang, S. Baker, 2011, Bioorganic & medicinal chemistry letters.

Anti‐HCV therapies in chimeric scid‐Alb/uPA mice parallel outcomes in human clinical application

Z. Ni, D. Tyrrell, A. Weiner, 2006, Hepatology.

Discovery of imidazo[1,2-a]-pyridine inhibitors of pan-PI3 kinases that are efficacious in a mouse xenograft model.

Yongjin Xu, Z. Ni, C. Voliva, 2016, Bioorganic & medicinal chemistry letters.

Structure guided optimization of a fragment hit to imidazopyridine inhibitors of PI3K.

Z. Ni, M. Wiesmann, C. Voliva, 2013, Bioorganic & medicinal chemistry letters.

Discovery of Investigational Drug CT1812, an Antagonist of the Sigma-2 Receptor Complex for Alzheimer's Disease.

G. Rishton, Z. Ni, Jason Zhang, 2021, ACS medicinal chemistry letters.

Peptide Deformylase Inhibitors as Antibacterial Agents: Identification of VRC3375, a Proline-3-Alkylsuccinyl Hydroxamate Derivative, by Using an Integrated Combinatorial and Medicinal Chemistry Approach

Z. Ni, D. Chen, Z. Yuan, 2004, Antimicrobial Agents and Chemotherapy.

A Maltose-Binding Protein Fusion Construct Yields a Robust Crystallography Platform for MCL1

T. Golub, G. Wei, Z. Ni, 2015, PloS one.

Encoded Combinatorial Chemistry: Binary Coding Using Chemically Robust Secondary Amine Tags

C. Holmes, Z. Ni, M. Gallop, 1997 .

Synthesis and in Vitro and in Vivo Evaluation of Phosphoinositide-3-kinase Inhibitors.

E. Iwanowicz, Z. Ni, T. Hendrickson, 2011, ACS medicinal chemistry letters.

Novel macrocyclic HCV NS3 protease inhibitors derived from α-amino cyclic boronates.

William McDowell, Yang Liu, Dazhong Fan, 2010, Bioorganic & medicinal chemistry letters.