A. Murchie

发表

Structure-based drug design targeting an inactive RNA conformation: exploiting the flexibility of HIV-1 TAR RNA.

J. Karn, P. Vaglio, A. Murchie, 2004, Journal of molecular biology.

Global structure of four-way RNA junctions studied using fluorescence resonance energy transfer.

D. Lilley, A. Murchie, F. Walter, 1998, RNA.

Fluorescence energy transfer shows that the four-way DNA junction is a right-handed cross of antiparallel molecules

D. Lilley, A. Murchie, R. Clegg, 1989, Nature.

Integron-Derived Aminoglycoside-Sensing Riboswitches Control Aminoglycoside Acetyltransferase Resistance Gene Expression

Dongrong Chen, A. Murchie, Shasha Wang, 2019, Antimicrobial Agents and Chemotherapy.

The structure of the holliday junction, and its resolution

D. Lilley, A. Murchie, S. Diekmann, 1988, Cell.

Rational design of inhibitors of HIV-1 TAR RNA through the stabilisation of electrostatic "hot spots".

Gabriele Varani, Mohammad Afshar, Ben Davis, 2004, Journal of molecular biology.

Human MutSalpha recognizes damaged DNA base pairs containing O6-methylguanine, O4-methylthymine, or the cisplatin-d(GpG) adduct.

D. Lilley, A. Murchie, D. R. Duckett, 1996, Proceedings of the National Academy of Sciences of the United States of America.

The bacterial ribosome, a promising focus for structure-based drug design.

A. Murchie, N. Foloppe, N. Matassova, 2002, Current opinion in pharmacology.

Solution structure of a parallel-stranded tetraplex formed by d(TG4T) in the presence of sodium ions by nuclear magnetic resonance spectroscopy.

D. Lilley, A. Murchie, F. Aboul-Ela, 1994, Journal of molecular biology.

Mutational analysis of the DNA binding domain A of chromosomal protein HMG1.

D. Lilley, A. Murchie, M. Bianchi, 1994, Nucleic acids research.

Human MutScv recognizes damaged DNA base pairs containing 06-methylguanine, 04-methylthymine, or the cisplatin-d(GpG) adduct

D. Lilley, A. Murchie, D. R. Duckett, 2005 .

Supercoiled DNA and cruciform structures.

D. Lilley, A. Murchie, 1992, Methods in enzymology.

Transcriptome Profiling of Cellular Response to Kanamycin B in E.coli

Dongrong Chen, A. Murchie, Ya-Lan Chang, 2021 .

Cruciform Extrusion in Supercoiled DNA — Mechanisms and Contextual Influence

D. Lilley, A. Murchie, K. Sullivan, 1988 .

The Extrusion of Cruciform Structures in Supercoiled DNA — Kinetics and Mechanisms

D. Lilley, A. Murchie, K. Sullivan, 1987 .

Folding of the four-way RNA junction of the hairpin ribozyme.

D. Lilley, A. Murchie, F. Walter, 1998, Biochemistry.

Transcriptome profiling in response to Kanamycin B reveals its wider non-antibiotic cellular function in Escherichia coli

Dongrong Chen, A. Murchie, Yaowen Chang, 2022, Frontiers in Microbiology.

Aminoglycoside riboswitch control of the expression of integron associated aminoglycoside resistance adenyltransferases

Dongrong Chen, A. Murchie, Shasha Wang, 2020, Virulence.

Nuclear magnetic resonance study of a deoxyoligonucleotide duplex containing a three base bulge.

D. Lilley, A. Murchie, S. Homans, 1993, Journal of molecular biology.

Identification and characterization of the mitochondrial RNA polymerase and transcription factor in the fission yeast Schizosaccharomyces pombe

Dongrong Chen, A. Murchie, Zhe Wang, 2011, Nucleic acids research.

Structure-based design of agents targeting the bacterial ribosome.

A. Murchie, M. Drysdale, J. Bower, 2003, Bioorganic & medicinal chemistry letters.

Structural basis for contrasting activities of ribosome binding thiazole antibiotics.

A. Murchie, R. Klinck, G. Lentzen, 2003, Chemistry & biology.

The high-resolution crystal structure of a parallel-stranded guanine tetraplex.

P C Moody, D. Lilley, A. Murchie, 1994, Science.

Crystal structure of the nosiheptide-resistance methyltransferase of Streptomyces actuosus.

Pei Zhou, Xu Jia, Ze Li, 2010, Biochemistry.

The crystal structure of a parallel-stranded guanine tetraplex at 0.95 A resolution.

D. Lilley, Z. Dauter, A. Murchie, 1997, Journal of molecular biology.

A novel function of the mitochondrial transcription factor Mtf1 in fission yeast; Mtf1 regulates the nuclear transcription of srk1

Dongrong Chen, J. Bähler, A. Murchie, 2010, Nucleic acids research.

Folding of the hairpin ribozyme in its natural conformation achieves close physical proximity of the loops.

D. Lilley, A. Murchie, F. Walter, 1998, Molecular cell.

Structure and activity of the hairpin ribozyme in its natural junction conformation: effect of metal ions.

D. Lilley, A. Murchie, F. Walter, 1998, Biochemistry.

Nucleic acid structure and recognition.

D. Lilley, A. Murchie, R. Clegg, 1997, Biophysical chemistry.

Ionic interactions and the global conformations of the hammerhead ribozyme

D. Lilley, A. Murchie, David M.J. Lilley, 1995, Nature Structural Biology.

Structure of Parallel-Stranded Guanine Tetraplexes

D. Lilley, A. Murchie, B. Luisi, 1995 .

NMR study of parallel-stranded tetraplex formation by the hexadeoxynucleotide d(TG4T)

D. Lilley, A. Murchie, F. Aboul-ela, 1992, Nature.

Uranyl photoprobing of a four‐way DNA junction: evidence for specific metal ion binding.

D. Lilley, A. Murchie, P. Nielsen, 1994, The EMBO journal.

The mechanism of cruciform formation in supercoiled DNA: initial opening of central basepairs in salt-dependent extrusion.

D. Lilley, A. Murchie, 1987, Nucleic acids research.

The function of twister ribozyme variants in non-LTR retrotransposition in Schistosoma mansoni

Dongrong Chen, A. Murchie, Wenxia Sun, 2021, Nucleic acids research.

RNA as a drug target.

Mohammad Afshar, Fareed Aboul-Ela, A. Murchie, 2002, Progress in medicinal chemistry.

Ion‐induced folding of the hammerhead ribozyme: a fluorescence resonance energy transfer study

D. Lilley, A. Murchie, R. Clegg, 1997, The EMBO journal.

Riboswitch Control of Aminoglycoside Antibiotic Resistance

Dongrong Chen, A. Murchie, Weizhi He, 2013, Cell.

Base methylation and local DNA helix stability. Effect on the kinetics of cruciform extrusion.

D. Lilley, A. Murchie, A I Murchie, 1989, Journal of molecular biology.

Fluorescence resonance energy transfer analysis of the structure of the four-way DNA junction.

D. Lilley, A. Murchie, R. Clegg, 1992, Biochemistry.

The Global Transcriptional Response of Fission Yeast to Hydrogen Sulfide

Dongrong Chen, A. Murchie, Weizhi He, 2011, PloS one.

Interactions between the 5′ UTR mRNA of the spe2 gene and spermidine regulate translation in S. pombe

Dongrong Chen, A. Murchie, Wenxia Sun, 2019, RNA.

RNA bulges and the helical periodicity of double-stranded RNA

D. Lilley, A. Murchie, A. Bhattacharyya, 1990, Nature.

Interactions between SAM and the 5′ UTR mRNA of the sam1 gene regulate translation in S. pombe

Dongrong Chen, A. Murchie, Wenxia Sun, 2019, RNA.

Severe axial bending of RNA induced by the U1A binding element present in the 3' untranslated region of the U1A mRNA.

D. Lilley, A. Murchie, D. Norman, 1997, Journal of molecular biology.

Model for the interaction of DNA junctions and resolving enzymes.

D. Lilley, A. Murchie, S. Diekmann, 1991, Journal of molecular biology.

Targeting mitochondrial transcription in fission yeast with ETB, an inhibitor of HSP60, the chaperone that binds to the mitochondrial transcription factor Mtf1

Dongrong Chen, A. Murchie, Wenxia Sun, 2012, Genes to Cells.

Helix opening transitions in supercoiled DNA.

D. Lilley, A. Murchie, R. Bowater, 1992, Biochimica et biophysica acta.

An aminoglycoside sensing riboswitch controls the expression of aminoglycoside resistance acetyltransferase and adenyltransferases.

Dongrong Chen, A. Murchie, 2014, Biochimica et biophysica acta.

Riboswitch control of induction of aminoglycoside resistance acetyl and adenyl-transferases

Dongrong Chen, A. Murchie, Weizhi He, 2013, RNA biology.

Tetraplex folding of telomere sequences and the inclusion of adenine bases.

D. Lilley, A. Murchie, A.I. Murchie, 1994, The EMBO journal.

The structure of DNA junctions and their interaction with enzymes.

D. Lilley, A. Murchie, R. Clegg, 1992, European journal of biochemistry.

The solution structure of the four-way DNA junction at low-salt conditions: a fluorescence resonance energy transfer analysis.

D. Lilley, A. Murchie, R. Clegg, 1994, Biophysical journal.

Structure of the four-way DNA junction and its interaction with proteins.

D. Lilley, A. Murchie, D. R. Duckett, 1995, Philosophical transactions of the Royal Society of London. Series B, Biological sciences.

The role of metal ions in the conformation of the four‐way DNA junction.

D. Lilley, A. Murchie, D. R. Duckett, 1990, The EMBO journal.

Exchange between stacking conformers in a four-Way DNA junction.

D. Lilley, A. Murchie, R. J. Grainger, 1998, Biochemistry.

T4 endonuclease VII cleaves DNA containing a cisplatin adduct.

D. Lilley, A. Murchie, 1993, Journal of molecular biology.

Resolution of model Holliday junctions by yeast endonuclease: effect of DNA structure and sequence.

D. Lilley, A. Murchie, S. C. West, 1989, The EMBO journal.

The global folding of four-way helical junctions in RNA, including that in U1 snRNA

D. Lilley, A. Murchie, D. R. Duckett, 1995, Cell.

The tertiary structure of the four-way DNA junction affords protection against DNase I cleavage.

D. Lilley, A. Murchie, J. Portugal, 1990, Nucleic acids research.

Observing the helical geometry of double-stranded DNA in solution by fluorescence resonance energy transfer.

D. Lilley, A. Murchie, R. Clegg, 1993, Proceedings of the National Academy of Sciences of the United States of America.

Genome-wide identification of Kanamycin B binding RNA in Escherichia coli

Dongrong Chen, A. Murchie, Wenxia Sun, 2023, BMC Genomics.

Substrate Recognition and Modification by the Nosiheptide Resistance Methyltransferase

Dongrong Chen, A. Murchie, Sitao Yin, 2015, PloS one.

The Effects of Aminoglycoside Antibiotics on Twister Ribozyme Cleavage.

Dongrong Chen, A. Murchie, Wenxia Sun, 2020, The FEBS Journal.

Kinking of DNA and RNA helices by bulged nucleotides observed by fluorescence resonance energy transfer.

D. Lilley, A. Murchie, R. Clegg, 1994, Proceedings of the National Academy of Sciences of the United States of America.

The identification and characterization of a selected SAM-dependent methyltransferase ribozyme that is present in natural sequences

Dongrong Chen, A. Murchie, J. Gan, 2021, Nature Catalysis.

Retinoblastoma susceptibility genes contain 5' sequences with a high propensity to form guanine-tetrad structures

Alastair I.H. Murchie, David M.J. Lilley, D. Lilley, 1992, Nucleic Acids Res..

Global structure of three-way DNA junctions with and without additional unpaired bases: a fluorescence resonance energy transfer analysis.

D. Lilley, A. Murchie, R. Clegg, 1997, Biochemistry.

RNA folding and misfolding of the hammerhead ribozyme.

D. Lilley, A. Murchie, N. Møllegaard, 1999, Biochemistry.

The ion-induced folding of the hammerhead ribozyme: core sequence changes that perturb folding into the active conformation.

D. Lilley, A. Murchie, G. Bassi, 1996, RNA.

Osmium tetroxide as a probe of RNA structure.

Dongrong Chen, A. Murchie, Jun Zhang, 2017, RNA.

Localized chemical hyperreactivity in supercoiled DNA: evidence for base unpairing in sequences that induce low-salt cruciform extrusion.

D. Lilley, A. Murchie, K. Sullivan, 1989, Biochemistry.

Identification of Hammerhead-variant ribozyme sequences in SARS-CoV-2

Dongrong Chen, A. Murchie, Getong Liu, 2024, Nucleic acids research.

The four-way DNA junction: a fluorescence resonance energy transfer study.

D. Lilley, A. Murchie, R. Clegg, 1993, Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas.