S. Brem

V. Mathura, S. Brem, V. Laporte, 2008, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis.

The prevention of oxyhemoglobin-induced endothelial and smooth muscle cytoskeletal injury by deferoxamine.

S. Brem, H. Schipper, Y. Comair, 1993, Neurosurgery.

Vascular complications after radiosurgery for meningiomas.

A. Sloan, S. Brem, K. Barami, 2007, Neurosurgical focus.

Angiogenesis and blood-brain barrier breakdown modulate CT contrast enhancement: an experimental study in a rabbit brain-tumor model.

S. Brem, D. Zagzag, M. Goldenberg, 1989, AJR. American journal of roentgenology.

Angiogenesis: a marker for neoplastic transformation of mammary papillary hyperplasia.

S. Brem, P. Gullino, D. Medina, 1977, Science.

Angiogenic activity of the atherosclerotic carotid artery plaque.

S. Brem, N. Kalant, F. Robert, 1989, Journal of neurosurgery.

Quantitative Methods to Evaluate Angiogenesis and Angiosuppression: A Rapid Immunocytochemical Cytokinetic Brain Tumor Assay

S. Brem, S. Brien, 1992 .

Neovascularization and tumor growth in the rabbit brain. A model for experimental studies of angiogenesis and the blood-brain barrier.

S. Brem, D. Zagzag, F. Robert, 1988, The American journal of pathology.

Rapid in situ cellular kinetics of intracerebral tumor angiogenesis using a monoclonal antibody to bromodeoxyuridine.

S. Brem, D. Zagzag, S. Brien, 1989, Neurosurgery.

Artificial intelligence-based locoregional markers of brain peritumoral microenvironment

Z. R. Samani, S. Bakas, D. Parker, 2022, Scientific Reports.

The University of Pennsylvania glioblastoma (UPenn-GBM) cohort: advanced MRI, clinical, genomics, & radiomics

Zev A. Binder, William A. Parker, S. Bakas, 2022, Scientific Data.

AI-based Prognostic Imaging Biomarkers for Precision Neurooncology: the ReSPOND Consortium.

Christos Davatzikos, Spyridon Bakas, Adam P Dicker, 2020, Neuro-oncology.

Assessing variability in surgical decision making among attending neurosurgeons at an academic center.

Zarina S Ali, S. Brem, M. Grady, 2020, Journal of neurosurgery.

Suramin, an anticancer and angiosuppressive agent, inhibits endothelial cell binding of basic fibroblast growth factor, migration, proliferation, and induction of urokinase-type plasminogen activator.

H. Engelhard, S. Brem, S. Gately, 1994, Cancer research.

Anticopper treatment inhibits pseudopodial protrusion and the invasive spread of 9L gliosarcoma cells in the rat brain.

S. Brem, D. Zagzag, A. Tsanaclis, 1990, Neurosurgery.

Terson's syndrome: a reversible cause of blindness following subarachnoid hemorrhage.

D. Nicolle, S. Brem, I. Danys, 1992, Journal of neurosurgery.

MR susceptibility imaging for detection of tumor-associated macrophages in glioblastoma

Srikanth K. Iyer, S. Brem, W. Witschey, 2021, Journal of Neuro-Oncology.

An inflatable balloon catheter and liquid 125I radiation source (GliaSite Radiation Therapy System) for treatment of recurrent malignant glioma: multicenter safety and feasibility trial.

J. Olson, E. Shaw, S. Brem, 2003, Journal of neurosurgery.

NABTT 0306: A randomized phase II trial of EMD 121974 in conjunction with concomitant and adjuvant temozolomide with radiation therapy in patients with newly diagnosed glioblastoma multiforme (GBM).

J. Olson, T. Mikkelsen, S. Piantadosi, 2009, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Distinct tumor signatures using deep learning-based characterization of the peritumoral microenvironment in glioblastomas and brain metastases

Zahra Riahi Samani, Z. R. Samani, D. Parker, 2021, Scientific Reports.

Spinal subarachnoid hematoma: a hazard of lumbar puncture resulting in reversible paraplegia.

R. V. Van Uitert, D. Hafler, S. Brem, 1981, The New England journal of medicine.

Neovascularization Induced by the Cellular Component of Atherosclerotic Plaque

S. Brem, N. Kalant, G. Hoover, 1987 .

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases

John Y. K. Lee, S. Brem, D. O’Rourke, 2015, Radiation oncology.

NIMG-18. [18F]FLUCICLOVINE PET TO DISTINGUISH PSEUDOPROGRESSION FROM TUMOR PROGRESSION IN POST-TREATMENT GLIOBLASTOMA

John Y. K. Lee, S. Brem, D. O’Rourke, 2021, Neuro-Oncology.

Multiparametric MRI assessment of response to convection-enhanced intratumoral delivery of MDNA55, an interleukin-4 receptor targeted immunotherapy, for recurrent glioblastoma

Sumei Wang, S. Brem, S. Chawla, 2021, Surgical neurology international.

Tumor angiogenesis: a quantitative method for histologic grading.

J. Folkman, S. Brem, R. Cotran, 1972, Journal of the National Cancer Institute.

Statin immunolocalization in human brain tumors. Detection of noncycling cells using a novel marker of cell quiescence

S. Brem, S. Gately, H. Schipper, 1991, Cancer.

ProlongedTumorDormancyby Preventionof Neovascularization in the Vitreous1

A. Patz, J. Folkman, S. Brem, 1976 .

Identification and Characterization of Putative Tumor Suppressor NGB, a GTP-Binding Protein That Interacts with the Neurofibromatosis 2 Protein

D. Coppola, S. Nicosia, J. Cheng, 2007, Molecular and Cellular Biology.

Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma

Sumei Wang, S. Brem, S. Chawla, 2018, British Journal of Cancer.

Immunotherapy Multiparametric magnetic resonance imaging in the assessment of anti-EGFRvIII chimeric antigen receptor T cell therapy in patients with recurrent glioblastoma

Sumei Wang, S. Brem, S. Chawla, 2018 .

Association of Autologous Tumor Lysate-Loaded Dendritic Cell Vaccination With Extension of Survival Among Patients With Newly Diagnosed and Recurrent Glioblastoma

Steven R. Abram, T. Mikkelsen, S. Toms, 2022, JAMA oncology.

Subcellular Genomics: Pervasive within-mitochondrion SNV heteroplasmy revealed by single mitochondrion sequencing

J. Eberwine, G. Baltuch, S. Brem, 2018 .

Utilization of the HTSCA and CFU-C assay to identify two new 2-chloroethylnitrosourea congeners of amino acid amides with increased in vitro activity against human glioma compared with BCNU

S. Brem, W. Feindel, L. Panasci, 2004, Cancer Chemotherapy and Pharmacology.

Factors Associated with Increased Survival after Surgical Resection of Glioblastoma in Octogenarians

S. Brem, D. O’Rourke, M. Martinez-Lage, 2015, PloS one.

Role of Race in Short-Term Outcomes for 1700 Consecutive Patients Undergoing Brain Tumor Resection.

S. Brem, N. Malhotra, J. Schuster, 2020, Journal for healthcare quality : official publication of the National Association for Healthcare Quality.

Acknowledgement of Reviewers 2012

Steven D Chang, A. Friedman, D. Brat, 2013, Dysphagia (New York. Print).

Cells transfected with the basic fibroblast growth factor gene fused to a signal sequence are invasive in vitro and in situ in the brain.

S. Brem, M. Klagsbrun, S. Gately, 1995, Neurosurgery.

Three‐dimensional echo planar spectroscopic imaging for differentiation of true progression from pseudoprogression in patients with glioblastoma

Sanjeev Chawla, Suyash Mohan, Andrew A Maudsley, 2018, NMR in biomedicine.

Blocking Angiogenesis and Tumorigenesis with GFA-116, a Synthetic Molecule that Inhibits Binding of Vascular Endothelial Growth Factor to its Receptor

D. Coppola, S. Brem, S. Sebti, 2004, Cancer Research.

The Cycling Pool of Cells within Human Brain Tumors: In Situ Cytokinetics Using the Monoclonal Antibody Ki-67

S. Brem, J. Michaud, A. Tsanaclis, 1991, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Angiogenesis as a marker of preneoplastic lesions of the human breast

S. Brem, P. Gullino, H. Jensen, 1978, Cancer.

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Lin Zhang, S. Brem, D. O’Rourke, 2018, Nature Communications.

Inhibition of Angiogenesis by Aβ Peptides

D. Coppola, S. Brem, S. Sebti, 2004, Angiogenesis.

Intracranial Spread of Merkel Cell Carcinoma to the Cerebellopontine Angle

S. Brem, Surbhi Jain, T. McCardle, 2012, Journal of cutaneous medicine and surgery.

Phase 2 trial of copper depletion and penicillamine as antiangiogenesis therapy of glioblastoma.

T. Mikkelsen, S. Brem, S. Phuphanich, 2005, Neuro-oncology.

Phase 2 trial of copper depletion and penicillamine as antiangiogenesis

T. Mikkelsen, S. Brem, K. Carson, 2005 .

Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

S. Brem, S. Gately, A. Tsanaclis, 1992, Cancer.

A single dose of peripherally infused EGFRvIII-directed CAR T cells mediates antigen loss and induces adaptive resistance in patients with recurrent glioblastoma

K. Mansfield, S. Brem, D. O’Rourke, 2017, Science Translational Medicine.

A Patient-Derived Glioblastoma Organoid Model and Biobank Recapitulates Inter- and Intra-tumoral Heterogeneity

Zev A. Binder, D. Petrov, T. Lucas, 2019, Cell.

Local treatment of malignant brain tumors using implantable chemotherapeutic polymers.

G. Gallia, S. Brem, H. Brem, 2005, Journal of the National Comprehensive Cancer Network : JNCCN.

Central Nervous System Cancers, Version 3.2020, NCCN Clinical Practice Guidelines in Oncology.

P. Wen, N. Butowski, M. Mrugala, 2020, Journal of the National Comprehensive Cancer Network : JNCCN.

Synergistic immunotherapy of glioblastoma by dual targeting of IL-6 and CD40

Lin Zhang, S. Brem, Zhenqiang He, 2021, Nature Communications.

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Lin Zhang, S. Brem, D. O’Rourke, 2018, Nature Communications.

Chapter 1 – The Story of Glioblastoma: History and Modern Correlates

S. Brem, Jayesh P. Thawani, 2016 .

Senescence-associated-gene signature identifies genes linked to age, prognosis, and progression of human gliomas.

T. Yeatman, D. Coppola, S. Brem, 2014, Journal of geriatric oncology.

Association of plasma cell-free DNA with survival in patients with IDH wild-type glioblastoma

Zev A. Binder, Qi Long, S. Brem, 2021, Neuro-oncology advances.

Effect of Tumor-Treating Fields Plus Maintenance Temozolomide vs Maintenance Temozolomide Alone on Survival in Patients With Glioblastoma

Eilon D. Kirson, Yoram Palti, Steven A. Toms, 2017 .

NCCN Guidelines® Insights: Central Nervous System Cancers, Version 2.2022.

P. Wen, N. Butowski, M. Mrugala, 2023, Journal of the National Comprehensive Cancer Network : JNCCN.

A phase I/II trial of hydroxychloroquine in conjunction with radiation therapy and concurrent and adjuvant temozolomide in patients with newly diagnosed glioblastoma multiforme

A. Troxel, D. Heitjan, S. Brem, 2014, Autophagy.

Clinical Utility of Plasma Cell-Free DNA in Adult Patients with Newly Diagnosed Glioblastoma: A Pilot Prospective Study

Zev A. Binder, S. Brem, D. O’Rourke, 2019, Clinical Cancer Research.

Molecular Mechanisms of Central Nervous System Metastasis

S. Brem, A. Rojiani, M. Rojiani, 2010 .

Molecular Correlates of Long Survival in IDH-Wildtype Glioblastoma Cohorts.

L. Chin, S. Brem, M. Snuderl, 2020, Journal of neuropathology and experimental neurology.

Wnt-mediated endothelial transformation into mesenchymal stem cell–like cells induces chemoresistance in glioblastoma

Zev A. Binder, Lin Zhang, S. Brem, 2020, Science Translational Medicine.

In vitro Drug Response and Molecular Markers Associated with Drug Resistance in Malignant Gliomas

G. Barger, A. Sloan, S. Brem, 2006, Clinical Cancer Research.

A safety run‐in and randomized phase 2 study of cilengitide combined with chemoradiation for newly diagnosed glioblastoma (NABTT 0306)

M. Hegi, S. Brem, T. Batchelor, 2012, Cancer.

Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing.

J. Eberwine, S. Brem, M. Nasrallah, 2021, Neurosurgery.

Clinical activity of the EGFR tyrosine kinase inhibitor osimertinib in EGFR-mutant glioblastoma

Zev A. Binder, Hongjun Song, S. Brem, 2019, CNS oncology.

PDGF-mediated mesenchymal transformation renders endothelial resistance to anti-VEGF treatment in glioblastoma

Lin Zhang, S. Brem, D. O’Rourke, 2018, Nature Communications.

Vascular niche IL-6 induces alternative macrophage activation in glioblastoma through HIF-2α

Lin Zhang, S. Brem, D. O’Rourke, 2018, Nature Communications.

First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Steven R. Abram, T. Mikkelsen, S. Toms, 2018, Journal of Translational Medicine.

Commentary: "Zooming in" on Glioblastoma: Understanding Tumor Heterogeneity and Its Clinical Implications in the Era of Single-Cell Ribonucleic Acid Sequencing.

J. Eberwine, S. Brem, M. Nasrallah, 2021, Neurosurgery.

NCCN CLINICAL PRACTICE GUIDELINES IN ONCOLOGY Central Nervous System Cancers, Version 3.2020

er, P. Wen, N. Butowski, 2020 .

Chapter 3 – The Molecular Pathogenesis of Glioblastoma

S. Brem, K. Abdullah, C. Adamson, 2016 .

What is the etiology of human brain tumors?. A report on the first lebow conference

S. Brem, J. Moskal, J. Rozental, 1995, Cancer.

Molecular Neuropathology in Practice: Clinical Profiling and Integrative Analysis of Molecular Alterations in Glioblastoma

Zev A. Binder, S. Brem, D. O’Rourke, 2019, Academic pathology.

Relationship of gliomas to the ventricular walls

Andrew E. Sloan, Michael J. Schell, Steven Brem, 2009, Journal of Clinical Neuroscience.

Cancer susceptibility variants and the risk of adult glioma in a US case–control study

D. Brat, J. Olson, K. Egan, 2011, Journal of Neuro-Oncology.

Negative prognostic impact of epidermal growth factor receptor copy number gain in young adults with isocitrate dehydrogenase wild-type glioblastoma

Zev A. Binder, S. Brem, D. O’Rourke, 2019, Journal of Neuro-Oncology.

The potential role of basic fibroblast growth factor in the transformation of cultured primary human fetal astrocytes and the proliferation of human glioma (U-87) cells.

S. Brem, S. Gately, G. Soff, 1995, Neurosurgery.

Antiangiogenesis treatment for glioblastoma multiforme: challenges and opportunities.

E. Wong, S. Brem, 2008, Journal of the National Comprehensive Cancer Network : JNCCN.

Commentary: Complementary and Alternative Medicine for Gliomas: Systematic Review and Critical Appraisal of Current Literature.

S. Brem, F. Henderson, S. Bagley, 2023, Neurosurgery.

RNA-seq for identification of therapeutically targetable determinants of immune activation in human glioblastoma

G. Linette, S. Brem, D. O’Rourke, 2018, Journal of Neuro-Oncology.

Chapter 11 – Recurrent Glioblastoma

S. Brem, K. Abdullah, C. Adamson, 2016 .

Phase I trial of vorinostat combined with bevacizumab and CPT-11 in recurrent glioblastoma.

R. Murtagh, S. Brem, A. Rojiani, 2012, Neuro-oncology.

Angiogenesis antagonists: current clinical trials

S. Brem, 2004, Angiogenesis.

Angiogenesis and Brain Tumors

E. Wong, S. Brem, 2011 .

Advanced magnetic resonance imaging and spectroscopy in a case of neurocysticercosis from North America

S. Brem, S. Chawla, P. Gupta, 2021, The neuroradiology journal.

Brain network mapping and glioma pathophysiology

J. Suckling, S. Brem, A. Mandal, 2023, Brain communications.

Overview Oncologic, Endocrine & Metabolic: Recent advances in angiogenesis inhibitors

S. Brem, T. Fan, J. Gross, 1994 .

2 Variants Are Associatedwith Survival in Glioblastoma Patients

Susan M. Chang, M. Berger, J. Olson, 2012 .

Word Count : 3425 Number of Tables : 3 Number of Figures : 3 Statement of Translational Relevance : Glioblastoma

Susan M. Chang, M. Berger, J. Olson, 2012 .

Imaging and histopathologic correlates of plasma cell-free DNA concentration and circulating tumor DNA in adult patients with newly diagnosed glioblastoma

Zev A. Binder, S. Brem, R. Wolf, 2020, Neuro-oncology advances.

Histopathologic quantification of viable tumor versus treatment effect in surgically resected recurrent glioblastoma

Zev A. Binder, Angela N. Viaene, S. Brem, 2018, Journal of Neuro-Oncology.

Central nervous system cancers.

Henry Brem, Alessandro Olivi, Mark R Gilbert, 2011, Journal of the National Comprehensive Cancer Network : JNCCN.

Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases

John Y. K. Lee, S. Brem, D. O’Rourke, 2015, Radiation oncology.

Guidelines for the initial management of metastatic brain tumors: role of surgery, radiosurgery, and radiation therapy.

L. Carey, S. Brem, M. Ewend, 2008, Journal of the National Comprehensive Cancer Network : JNCCN.

Angiosuppressive and Antiproliferative Actions of Suramin: A Growth Factor Antagonist

H. Engelhard, S. Brem, S. Gately, 1993 .

A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting.

J. Olson, T. Mikkelsen, D. Louis, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Intracranial control after Cyberknife radiosurgery to the resection bed for large brain metastases

John Y. K. Lee, S. Brem, D. O’Rourke, 2015, Radiation oncology.

Spontaneous Temporary Remission in Primary CNS Lymphoma

S. Brem, Michael Rubin, M. Brisson, 1987, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

An era of rapid advancement: diagnosis and treatment of metastatic brain cancer.

S. Brem, J. G. Panattil, 2005, Neurosurgery.

Preservation of neurocognitive function and local control of 1 to 3 brain metastases treated with surgery and carmustine wafers

S. Brem, M. Ewend, C. Meyers, 2013, Cancer.

Central nervous system cancers: Clinical Practice Guidelines in Oncology.

Henry Brem, Alessandro Olivi, Deborah T Blumenthal, 2005, Journal of the National Comprehensive Cancer Network : JNCCN.

Overall and progression-free survival in metastatic melanoma: analysis of a single-institution database.

V. Sondak, S. Brem, D. Reintgen, 2006, Cancer control : journal of the Moffitt Cancer Center.

A rapid and modifiable technique for regional exposure in cerebral surgery. Technical note.

K. Elisevich, S. Brem, Y. Comair, 1987, Journal of neurosurgery.

Safety and Efficacy of Fractionated Stereotactic Radiotherapy in the Treatment of Skull Base Tumors: An Evidence-Based Approach

S. Brem, F. Vrionis, P. Chinnaiyan, 2010 .

Endoscopic fenestration of a giant frontal arachnoid cyst: Operative technique and anatomical nuances

S. Brem, O. Choudhri, A. Borja, 2022, Clinical case reports.

Demonstration of cell-mediated immunity to a human brain tumor: use of an in vitro microcytotoxicity assay.

S. Brem, N. de Tribolet, P. Kornblith, 1972, Surgical forum.

Treatment of Single Brain Metastasis with Resection, Intracavity Carmustine Polymer Wafers, and Radiation Therapy Is Safe and Provides Excellent Local Control

M. Gilbert, L. Carey, S. Brem, 2007, Clinical Cancer Research.

Vessel morphometric parameters-correlation with histologic grade and VEGF expression in oligodendroglioma.

S. Brem, A. Rojiani, Leah B. Strickland-Marmol, 2017, American journal of cancer research.

IMCT-15PILOT STUDY OF T CELLS REDIRECTED TO EGFRvIII WITH A CHIMERIC ANTIGEN RECEPTOR IN PATIENTS WITH EGFRvIII+ GLIOBLASTOMA

Donald M. O'Rourke, Suyash Mohan, Eileen Maloney, 2015 .

Differentiating Tumor Progression from Pseudoprogression in Patients with Glioblastomas Using Diffusion Tensor Imaging and Dynamic Susceptibility Contrast MRI

S. Brem, R. Wolf, M. Martinez-Lage, 2015, American Journal of Neuroradiology.

An Integrated Stress Response Agent that Modulates DR5-Dependent TRAIL Synergy Reduces Patient-Derived Glioma Stem Cell Viability

S. Brem, X. Tian, A. Tsourkas, 2019, Molecular Cancer Research.

Initial evidence that blood-borne microvesicles are biomarkers for recurrence and survival in newly diagnosed glioblastoma patients

S. Brem, R. Wolf, M. Putt, 2016, Journal of Neuro-Oncology.

Recent updates in the treatment of glioblastoma: introduction.

S. Brem, Minesh Mehta, 2014, Seminars in oncology.

Taming glioblastoma by targeting angiogenesis: 3 years later.

E. Wong, S. Brem, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Chapter 18 – Anaplastic Astrocytoma

S. Brem, S. Schold, A. Rojiani, 2005 .

Case Report: Prolonged Survival Following EGFRvIII CAR T Cell Treatment for Recurrent Glioblastoma

John Y. K. Lee, Zev A. Binder, Sumei Wang, 2021, Frontiers in Oncology.

Atherosclerosis as an Angiogenic Disease: Implications for the Pathogenesis and Therapy of Symptomatic Carotid Arterial Stenosis

S. Brem, 1992 .

Neovascularization and the atherosclerotic plaque.

S. Brem, 1990, CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne.

Second window ICG predicts gross-total resection and progression-free survival during brain metastasis surgery.

John Y. K. Lee, S. Singhal, S. Brem, 2020, Journal of neurosurgery.

Primary Cell Culture of Live Neurosurgically Resected Aged Adult Human Brain Cells and Single Cell Transcriptomics.

Timothy H Lucas, Gordon H Baltuch, John A Wolf, 2017, Cell reports.

Myiatic Scalp and Skull Infection with Diptera Sarcophaga: Case Report

S. Brem, E. Arbit, R. E. Varon, 1986 .

Impaired Orthotopic Glioma Growth and Vascularization in Transgenic Mouse Models of Alzheimer's Disease

V. Mathura, S. Brem, V. Laporte, 2010, The Journal of Neuroscience.

Ligation and Litigation

S. Brem, 1986, Canadian Journal of Neurological Sciences / Journal Canadien des Sciences Neurologiques.

Near-Infrared Imaging with Second-Window Indocyanine Green in Newly Diagnosed High-Grade Gliomas Predicts Gadolinium Enhancement on Postoperative Magnetic Resonance Imaging

John Y. K. Lee, S. Singhal, S. Brem, 2019, Molecular Imaging and Biology.

Quantification of tumor microenvironment acidity in glioblastoma using principal component analysis of dynamic susceptibility contrast enhanced MR imaging

C. Davatzikos, H. Akbari, S. Brem, 2021, Scientific Reports.

Subcellular omics: a new frontier pushing the limits of resolution, complexity and throughput

M. Bucan, Junhyong Kim, James Zou, 2023, Nature Methods.

Complete Response of a Recurrent, Multicentric Malignant Glioma in a Patient Treated with Phenylbutyrate

S. Brem, S. Phuphanich, S. Daniels, 2004, Journal of Neuro-Oncology.

A new approach to the problem of retinal neovascularization.

A. Patz, S. Brem, G. Lutty, 1978, Ophthalmology.

Taming glioblastoma: targeting angiogenesis.

E. Wong, S. Brem, 2007, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Microscopic paraseptal sphenoidotomy approach for pituitary tumors.

S. Brem, F. Vrionis, J. Sorenson, 2002, Cancer control : journal of the Moffitt Cancer Center.

Three-Dimensional Printed Modeling of Diffuse Low-Grade Gliomas and Associated White Matter Tract Anatomy

B. Pukenas, D. Parker, R. Verma, 2017, Neurosurgery.

Commentary: 5-Aminolevulinic Acid and Contrast-Enhanced Ultrasound: The Combination of the 2 Techniques to Optimize the Extent of Resection in Glioblastoma Surgery.

S. Brem, F. Henderson, 2020, Neurosurgery.

Effect of Vocimagene Amiretrorepvec in Combination With Flucytosine vs Standard of Care on Survival Following Tumor Resection in Patients With Recurrent High-Grade Glioma: A Randomized Clinical Trial.

Aliz R. Rao, William P. Accomando, C. Bettegowda, 2020, JAMA oncology.

Assessment of treatment response to dendritic cell vaccine in patients with glioblastoma using a multiparametric MRI-based prediction model

L. Liau, Sumei Wang, S. Brem, 2023, Journal of Neuro-Oncology.

Correction to: First results on survival from a large Phase 3 clinical trial of an autologous dendritic cell vaccine in newly diagnosed glioblastoma

Steven R. Abram, T. Mikkelsen, S. Toms, 2018, Journal of Translational Medicine.

Tumor growth regulation by modulation of basic fibroblast growth factor.

S. Brem, R. Horlick, K. Eidsvoog, 1992, EXS.

CTIM-13. PHASE 1 CLINICAL TRIAL OF ONCOLYTIC VIRAL IMMUNOTHERAPY WITH CAN-2409 + VALACYCLOVIR IN COMBINATION WITH NIVOLUMAB AND STANDARD OF CARE (SOC) IN NEWLY DIAGNOSED HIGH-GRADE GLIOMA (HGG)

F. Lieberman, P. Wen, R. Strowd, 2021, Neuro-Oncology.

CTIM-13. CLINICAL EFFICACY OF MDNA55, AN INTERLEUKIN-4 RECEPTOR TARGETED IMMUNOTHERAPY, IN RECURRENT GBM DELIVERED BY CONVECTION ENHANCED DELIVERY (CED)

N. Butowski, S. Kesari, S. Brem, 2020 .

A phase I trial of vorinostat in combination with bevacizumab and irinotecan in recurrent glioblastoma.

R. Murtagh, S. Brem, A. Rojiani, 2010 .

LTBK-01. INO-5401 AND INO-9012 DELIVERED INTRAMUSCULARLY (IM) WITH ELECTROPORATION (EP) IN COMBINATION WITH CEMIPLIMAB (REGN2810) IN NEWLY DIAGNOSED GLIOBLASTOMA

F. Lieberman, D. Weiner, S. Brem, 2020 .

INO-5401 and INO-9012 delivered intramuscularly (IM) with electroporation (EP) in combination with cemiplimab (REGN2810) in newly diagnosed glioblastoma (GBM): Interim results.

D. Weiner, S. Brem, I. Lowy, 2020 .

Differentiation of brain infection from necrotic glioblastoma using combined analysis of diffusion and perfusion MRI

Sumei Wang, S. Brem, S. Chawla, 2019, Journal of magnetic resonance imaging : JMRI.

CrOssing fiber Modeling in the Peritumoral Area using dMRI (COMPARI)

D. Parker, R. Verma, S. Brem, 2023, bioRxiv.

Freewater estimatoR using iNtErpolated iniTialization (FERNET): Characterizing peritumoral edema using clinically feasible diffusion MRI data

Ragini Verma, Drew Parker, Ofer Pasternak, 2020, PloS one.

Edema-Informed Anatomically Constrained Particle Filter Tractography

Rachid Deriche, Maxime Descoteaux, Ragini Verma, 2018, MICCAI.

Central nervous system cancers.

L. Recht, A. Friedman, P. Bierman, 2011, Journal of the National Comprehensive Cancer Network : JNCCN.

Targeting the IL4 receptor with MDNA55 in patients with recurrent glioblastoma: Results of a phase IIb trial

N. Butowski, S. Kesari, S. Brem, 2023, Neuro-oncology.

Intramuscular (IM) INO-5401 + INO-9012 with electroporation (EP) in combination with cemiplimab (REGN2810) in newly diagnosed glioblastoma.

F. Lieberman, S. Brem, I. Lowy, 2022, Journal of Clinical Oncology.

Modified RANO, Immunotherapy RANO, and Standard RANO Response to Convection-Enhanced Delivery of IL4R-Targeted Immunotoxin MDNA55 in Recurrent Glioblastoma

N. Butowski, S. Kesari, S. Brem, 2021, Clinical Cancer Research.

MDNA55: A locally administered IL4 guided toxin as a targeted treatment for recurrent glioblastoma.

N. Butowski, S. Kesari, S. Brem, 2019, Journal of Clinical Oncology.

Malignant brain tumors in the elderly.

S. Brem, P. M. Fernández, 1997, Clinics in geriatric medicine.

Arterial Spin Labeling and Dynamic Susceptibility Contrast-enhanced MR Imaging for evaluation of arteriovenous shunting and tumor hypoxia in glioblastoma

C. Davatzikos, J. Detre, H. Akbari, 2019, Scientific Reports.

Resecting the dominant lesion: Patient outcomes after surgery and radiosurgery vs stand-alone radiosurgery in the setting of multiple brain metastases

John Y. K. Lee, S. Brem, D. O’Rourke, 2021, Clinical Neurology and Neurosurgery.

An Era of Rapid Advancement: Diagnosis and Treatment of Metastatic Brain Cancer

S. Brem, J. G. Panattil, 2005 .

Pharmacokinetic analysis and pharmacodynamic evidence of autophagy inhibition in patients with newly diagnosed glioblastoma treated on a phase I trial of hydroxychloroquine in combination with adjuvant temozolomide and radiation (ABTC 0603).

T. Mikkelsen, S. Brem, P. O'dwyer, 2010 .

Immunolocalization of basic fibroblast growth factor to the micro vasculature of human brain tumors

S. Brem, S. Gately, A. Tsanaclis, 1992, Cancer.

An additive score optimized by a genetic learning algorithm predicts readmission risk after glioblastoma resection

S. Brem, D. O’Rourke, K. Abdullah, 2020, Journal of Clinical Neuroscience.

Addressing the Challenge of Edema in Fiber Tracking

Luke Macyszyn, Ragini Verma, Mark A. Elliott, 2014 .

Optic nerve meningioma: A case for expectant therapy

S. Brem, E. Arbit, Jack Wise And, 1986 .

Effects of surgery with BCNU wafer placement on neurocognitive function in patients with one to three brain metastases.

S. Brem, M. Ewend, C. Meyers, 2011, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Distinguishing Progression from Pseudoprogression in Glioblastoma Using 18F-Fluciclovine PET

John Y. K. Lee, S. Brem, D. O’Rourke, 2022, The Journal of Nuclear Medicine.

18F-Fluciclovine PET to distinguish treatment-related effects from disease progression in recurrent glioblastoma: PET fusion with MRI guides neurosurgical sampling

Vivek P. Buch, S. Brem, D. O’Rourke, 2019, Neuro-oncology practice.

Enhanced Fiber Tractography Using Edema Correction: Application and Evaluation in High-Grade Gliomas

T. Lucas, D. Parker, R. Verma, 2021, Neurosurgery.

Single Cell Spatial Chromatin Analysis of Fixed Immunocytochemically Identified Neuronal Cells

S. Anderson, Junhyong Kim, J. Eberwine, 2019, bioRxiv.

Mismatch repair protein mutations in isocitrate dehydrogenase (IDH)-mutant astrocytoma and IDH-wild-type glioblastoma

S. Brem, M. Snuderl, K. Hatanpaa, 2023, Neuro-oncology advances.

Association of partial T2-FLAIR mismatch sign and isocitrate dehydrogenase mutation in WHO grade 4 gliomas: results from the ReSPOND consortium

Zev A. Binder, Peter I. Kamel, Susan M. Chang, 2023, Neuroradiology.

Placebo-controlled trial of safety and efficacy of intraoperative controlled delivery by biodegradable polymers of chemotherapy for recurrent gliomas

S. Piantadosi, S. Brem, P. Burger, 1995, The Lancet.

Novel risk scores for survival and intracranial failure in patients treated with radiosurgery alone to melanoma brain metastases

John Y. K. Lee, S. Brem, D. O’Rourke, 2015, Radiation Oncology.

Gastroparesis Secondary to a Medulloblastoma of the Posterior Fossa

S. Brem, J. Stern, A. Szilágyi, 1987, Clinical Nuclear Medicine.

Necrotizing neurosarcoidosis masquerading as a left optic nerve meningioma: case report.

S. Brem, A. Rojiani, F. Murtagh, 2002, AJNR. American journal of neuroradiology.

Angiogenesis in brain tumors: a quantitative histologic study.

S. Brem, M. J. Folkman, S S Brem, 1974, Surgical forum.

Angiosuppression of Brain Tumors by Depletion of Copper and Penicillamine

S. Brem, D. Zagzag, S. Gately, 1992 .

Can calcium antagonists affect the hemostatic mechanism and promote rebleeding? An experimental study.

S. Brem, E. Arbit, M. Hier, 1987, Neurosurgery.

Commentary: The Role of Laser Interstitial Thermal Therapy in Surgical Neuro-Oncology: Series of 100 Consecutive Patients.

S. Brem, F. Henderson, 2019, Neurosurgery.

S. Brem, F. Davis, S. Freels, 1998, Journal of neurosurgery.

Use of diffusion tensor imaging in glioma resection.

S. Brem, K. Abdullah, D. Lubelski, 2013, Neurosurgical focus.

Abstract LB-083: Phase I study of T cells redirected to EGFRvIII with a chimeric antigen receptor in patients with EGFRvIII+ glioblastoma

K. Mansfield, Sumei Wang, S. Brem, 2016 .

Taming Glioblastoma in 'Real Time': Integrating Multimodal Advanced Neuroimaging/AI Tools Towards Creating a Robust and Therapy Agnostic Model for Response Assessment in Neuro-Oncology".

S. Brem, S. Chawla, S. Mohan, 2023, Clinical Cancer Research.