Xuechu Zhen

发表

Molecular Modeling of the 3D Structure of 5-HT1AR: Discovery of Novel 5-HT1AR Agonists via Dynamic Pharmacophore-Based Virtual Screening

Bo Gao, Hualiang Jiang, Kunqian Yu, 2013, J. Chem. Inf. Model..

Identification of N-propylnoraporphin-11-yl 5-(1,2-dithiolan-3-yl)pentanoate as a new anti-Parkinson's agent possessing a dopamine D2 and serotonin 5-HT1A dual-agonist profile.

Shanglin Zhou, Bo Gao, Xuechu Zhen, 2011, Journal of medicinal chemistry.

Asymmetric total synthesis and identification of tetrahydroprotoberberine derivatives as new antipsychotic agents possessing a dopamine D(1), D(2) and serotonin 5-HT(1A) multi-action profile.

Kaixian Chen, Hualiang Jiang, Hong Liu, 2013, Bioorganic & Medicinal Chemistry.

FoxO3a suppresses neuropeptide W expression in neuronal cells and in rat hypothalamus and its implication in hypothalamic-pituitary-adrenal (HPA) axis

Xuechu Zhen, P. Lazarovici, Fengxia Yan, 2020, International journal of biological sciences.

Discovery of novel inhibitors targeting the macrophage migration inhibitory factor via structure-based virtual screening and bioassays.

Youyong Li, Xuechu Zhen, L. Zheng, 2014, Journal of medicinal chemistry.

Discovery of Novel and Selective Adenosine A2A Receptor Antagonists for Treating Parkinson's Disease through Comparative Structure-Based Virtual Screening

Youyong Li, T. Hou, Xuechu Zhen, 2017, J. Chem. Inf. Model..

Absorption, Distribution, Metabolism, Excretion, and Toxicity Evaluation in Drug Discovery. 14. Prediction of Human Pregnane X Receptor Activators by Using Naive Bayesian Classification Technique.

Dan Li, Sheng Tian, Huidong Yu, 2015, Chemical research in toxicology.

Prediction of chemical biodegradability using computational methods

Sheng Tian, Xuechu Zhen, Zhixiong Zhan, 2017 .

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

J. Waddington, Xuechu Zhen, P. Moran, 2017, British journal of pharmacology.

Estrogen-modulated frontal cortical CaMKII activity and behavioral supersensitization induced by prolonged cocaine treatment in female rats

Xuechu Zhen, M. Frankfurt, E. Friedman, 2007, Psychopharmacology.

Distinctive nicotinic acetylcholine receptor functional phenotypes of rat ventral tegmental area dopaminergic neurons

Xuechu Zhen, R. Lukas, Qiang Liu, 2009, The Journal of physiology.

Update 1 of: Recent progress in development of dopamine receptor subtype-selective agents: potential therapeutics for neurological and psychiatric disorders.

R. Baldessarini, Xuechu Zhen, Na Ye, 2013, Chemical reviews.

Naja naja atra venom ameliorates pulmonary fibrosis by inhibiting inflammatory response and oxidative stress

Xuechu Zhen, Guanghui Wang, Z. Qin, 2014, BMC Complementary and Alternative Medicine.

Early glycolytic reprogramming controls microglial inflammatory activation

Xuechu Zhen, L. Zheng, Huicui Yang, 2021, Journal of neuroinflammation.

Early glycolytic reprogramming controls microglial inflammatory activation

Xuechu Zhen, L. Zheng, Huicui Yang, 2020, Journal of Neuroinflammation.

Lithium regulates protein tyrosine phosphatase activity in vitro and in vivo

Xuechu Zhen, E. Friedman, C. Torres, 2002, Psychopharmacology.

Dopamine D 1 Receptor Ligands: Where AreWe Now and Where AreWe Going

Xuechu Zhen, A. Zhang, B. Xiong, 2009 .

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

Xuechu Zhen, H. Ren, Guanghui Wang, 2012, Molecular Neurodegeneration.

The Extracellular Î±-Synuclein and its Biological Significance

Xuechu Zhen, Lin Guo, 2013 .

Sigma-1 receptor regulates mitophagy in dopaminergic neurons and contributes to dopaminergic protection

J. Waddington, Xuechu Zhen, T. He, 2020, Neuropharmacology.

Clk1 deficiency promotes neuroinflammation and subsequent dopaminergic cell death through regulation of microglial metabolic reprogramming

J. Waddington, Xuechu Zhen, L. Zheng, 2017, Brain, Behavior, and Immunity.

Allosteric modulation of sigma‐1 receptors elicits anti‐seizure activities

Xuechu Zhen, Lin Guo, A. Zhang, 2015, British journal of pharmacology.

SKF83959 Is a Potent Allosteric Modulator of Sigma-1 Receptor

Xuechu Zhen, Lin Guo, A. Zhang, 2013, Molecular Pharmacology.

Antiinflammatory effects of orientin-2"-O-galactopyranoside on lipopolysaccharide-stimulated microglia.

Bo Gao, Xuechu Zhen, L. Zheng, 2014, Biological & pharmaceutical bulletin.

Functional reversal of (−)‐Stepholidine analogues by replacement of benzazepine substructure using the ring‐expansion strategy

Lili Xu, Xuechu Zhen, Wei-Chang Fu, 2016, Chemical biology & drug design.

Dopamine D1 receptor ligands: Where are we now and where are we going

Xuechu Zhen, A. Zhang, B. Xiong, 2009, Medicinal research reviews.

PSD-95 regulates D1 dopamine receptor resensitization, but not receptor-mediated Gs-protein activation

Wei Cheng, Xuechu Zhen, Jie Zheng, 2009, Cell Research.

C9orf72 associates with inactive Rag GTPases and regulates mTORC1‐mediated autophagosomal and lysosomal biogenesis

Xuechu Zhen, J. Prehn, Guanghui Wang, 2020, Aging cell.

Allosteric modulation of sigma‐1 receptors by SKF83959 inhibits microglia‐mediated inflammation

Xuechu Zhen, Lin Guo, L. Zheng, 2015, Journal of neurochemistry.

Mitogen-activated Protein Kinase p38 Mediates Regulation of Chondrocyte Differentiation by Parathyroid Hormone*

Xuechu Zhen, Qiuqian Wu, Qian Chen, 2001, The Journal of Biological Chemistry.

Knockdown of milk‐fat globule EGF factor‐8 suppresses glioma progression in GL261 glioma cells by repressing microglial M2 polarization

Xuechu Zhen, L. Zheng, Huicui Yang, 2020, Journal of cellular physiology.

CMYA5: a new potential substrate of Kcna3 in human heart.

Xuechu Zhen, H. Fan, Zhongmin Liu, 2013, Acta biochimica et biophysica Sinica.

A small molecule antagonist of SMN disrupts the interaction between SMN and RNAP II

Xinghua Guo, J. Greenblatt, J. Min, 2022, Nature Communications.

Inhibition of macrophage migration inhibitory factor (MIF) tautomerase activity suppresses microglia‐mediated inflammatory responses

Xuechu Zhen, L. Zheng, Tingjun Hou, 2016, Clinical and experimental pharmacology & physiology.

D 1 Dopamine Receptor Agonists Mediate Activation of p38 Mitogen-Activated Protein Kinase and c-Jun Amino-Terminal Kinase by a Protein Kinase A-Dependent Mechanism in SK-N-MC Human Neuroblastoma Cells

Xuechu Zhen, K. Uryu, Hoau Yan Wang, 1998 .

Inhibition of Neuroinflammation by Synthetic Androstene Derivatives Incorporating Amino Acid Methyl Esters on Activated BV‐2 Microglia

Xuechu Zhen, L. Zheng, B. Jiang, 2015, ChemMedChem.

miRNA-3473b contributes to neuroinflammation following cerebral ischemia

Xuechu Zhen, Jian Cheng, J. Jia, 2018, Cell Death & Disease.

The role of the phosphatidyinositol-linked D1 dopamine receptor in the pharmacology of SKF83959

Xuechu Zhen, E. Friedman, S. Goswami, 2005, Pharmacology Biochemistry and Behavior.

Dopamine D1 receptors mediate methamphetamine-induced dopaminergic damage: involvement of autophagy regulation via the AMPK/FOXO3A pathway

J. Waddington, Xuechu Zhen, L. Zheng, 2022, Psychopharmacology.

Synthesis and pharmacological investigation of novel 2-aminothiazole-privileged aporphines.

Xuechu Zhen, Xuechu Zhen, Zhili Liu, 2008, Bioorganic & medicinal chemistry.

The Retardation of Myometrial Infiltration, Reduction of Uterine Contractility, and Alleviation of Generalized Hyperalgesia in Mice With Induced Adenomyosis by Levo-Tetrahydropalmatine (l-THP) and Andrographolide

Andrew V. Carter, Yuedong Wang, Xuechu Zhen, 2011, Reproductive Sciences.

Synthesis of dihydrofuroaporphine derivatives: identification of a potent and selective serotonin 5-HT 1A receptor agonist.

Xuechu Zhen, Hai Zhang, Na Ye, 2010, Journal of medicinal chemistry.

CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation.

Xuechu Zhen, N. Alkayed, Jian Cheng, 2014, Antioxidants & redox signaling.

Activation of AMPK/mTORC1-Mediated Autophagy by Metformin Reverses Clk1 Deficiency-Sensitized Dopaminergic Neuronal Death

J. Waddington, Xuechu Zhen, L. Zheng, 2017, Molecular Pharmacology.

Protective Effect of Metformin against Hydrogen Peroxide-Induced Oxidative Damage in Human Retinal Pigment Epithelial (RPE) Cells by Enhancing Autophagy through Activation of AMPK Pathway

Xuechu Zhen, Xia Zhao, Yizhou Jiang, 2020, Oxidative medicine and cellular longevity.

Anti-inflammatory effects of glaucocalyxin B in microglia cells.

Fali Zhang, Ping Gan, Jian Zhang, 2015, Journal of pharmacological sciences.

Design, synthesis and evaluation of a series of non-steroidal anti-inflammatory drug conjugates as novel neuroinflammatory inhibitors.

Xuechu Zhen, Xuechu Zhen, L. Zheng, 2015, International immunopharmacology.

Evaluation of the antipsychotic effect of bi-acetylated l-stepholidine (l-SPD-A), a novel dopamine and serotonin receptor dual ligand

Xuechu Zhen, Hai Zhang, Jianjun Cheng, 2009, Schizophrenia Research.

L166P mutant DJ-1 promotes cell death by dissociating Bax from mitochondrial Bcl-XL

Xuechu Zhen, H. Ren, Guanghui Wang, 2012, Molecular Neurodegeneration.

Current developments of macrophage migration inhibitory factor (MIF) inhibitors.

Huiyong Sun, Sheng Tian, Xuechu Zhen, 2013, Drug discovery today.

Sigma-1 Receptor-Modulated Neuroinflammation in Neurological Diseases

Xuechu Zhen, Jian Cheng, J. Jia, 2018, Front. Cell. Neurosci..

Levo-Tetrahydropalmatine Retards the Growth of Ectopic Endometrial Implants and Alleviates Generalized Hyperalgesia in Experimentally Induced Endometriosis in Rats

Xuechu Zhen, Xi-shi Liu, Ting Zhao, 2011, Reproductive Sciences.

Developmental Genes and Regulatory Proteins, Domains of Cognitive Impairment in Schizophrenia Spectrum Psychosis and Implications for Antipsychotic Drug Discovery: The Example of Dysbindin-1 Isoforms and Beyond

J. Waddington, Xuechu Zhen, C. O’Tuathaigh, 2020, Frontiers in Pharmacology.

Development of Adenosine A2A Receptor Antagonists for the Treatment of Parkinson's Disease: A Recent Update and Challenge.

Xuechu Zhen, Xiaohu Zhang, Jiyue Zheng, 2018, ACS chemical neuroscience.

Robo3.1A suppresses Slit‐mediated repulsion by triggering degradation of Robo2

Xuechu Zhen, Lingyong Li, Shengbing Liu, 2014, Journal of neuroscience research.

Estrogen regulates responses of dopamine neurons in the ventral tegmental area to cocaine

Xuechu Zhen, Die Zhang, Shen Yang, 2008, Psychopharmacology.

Sigma-2 receptor ligands: neurobiological effects.

Xuechu Zhen, Lin Guo, 2015, Current medicinal chemistry.

1-O-tigloyl-1-O-deacetyl-nimbolinin B inhibits LPS-stimulated inflammatory responses by suppressing NF-κB and JNK activation in microglia cells.

Fali Zhang, Jing Wu, Xuechu Zhen, 2014, Journal of pharmacological sciences.

SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor‐independent mechanism

G. Hu, Shanglin Zhou, Xuechu Zhen, 2011, Journal of neuroscience research.

GABA Neurons in the Ventral Tegmental Area Responding to Peripheral Sensory Input

Xuechu Zhen, M. Gao, G. Jin, 2012, PloS one.

D2 receptor-mediated miRNA-143 expression is associated with the effects of antipsychotic drugs on phencyclidine-induced schizophrenia-related locomotor hyperactivity and with Neuregulin-1 expression in mice

J. Waddington, Xuechu Zhen, Yiguo Jiang, 2019, Neuropharmacology.

Higher-Affinity Agonists of 5-HT1AR Discovered through Tuning the Binding-Site Flexibility

Peng Lian, Wei Fu, LinLang Li, 2015, J. Chem. Inf. Model..

Development and Evaluation of Novel Metformin Derivative Metformin Threonate for Brain Ischemia Treatment

Xuechu Zhen, Weipeng Wang, Hongjian Zhang, 2022, Frontiers in Pharmacology.

(6aR)-11-Amino-N-propyl-noraporphine, a new dopamine D2 and serotonin 5-HT1A dual agonist, elicits potent antiparkinsonian action and attenuates levodopa-induced dyskinesia in a 6-OHDA-lesioned rat model of Parkinson's disease

Xuechu Zhen, Lin Guo, L. Zheng, 2014, Pharmacology Biochemistry and Behavior.

Further SAR study on 11-O-substituted aporphine analogues: identification of highly potent dopamine D3 receptor ligands.

Bo Gao, Xuechu Zhen, Na Ye, 2011, Bioorganic & medicinal chemistry.

Prefrontal cortex gates acute morphine action on dopamine neurons in the ventral tegmental area

Xuechu Zhen, Qianqian Wu, Chang-liang Liu, 2015, Neuropharmacology.

Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

J. Waddington, Xuechu Zhen, Huicui Yang, 2017, Psychopharmacology.

Phosphodiesterase 10A inhibition attenuates sleep deprivation-induced deficits in long-term fear memory

Xuechu Zhen, H. Ren, Zhuangli Guo, 2016, Neuroscience Letters.

SKF83959 selectively regulates phosphatidylinositol‐linked D1 dopamine receptors in rat brain

Xuechu Zhen, G. Cai, E. Friedman, 2003, Journal of neurochemistry.

PHLDA1 promotes microglia-mediated neuroinflammation via regulating K63-linked ubiquitination of TRAF6

Xuechu Zhen, L. Zheng, Wenhua Zheng, 2020, Brain, Behavior, and Immunity.

Neuropharmacological Actions of Metformin in Stroke

Xuechu Zhen, Jian Cheng, J. Jia, 2015, Current neuropharmacology.

Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke

Xuechu Zhen, Huicui Yang, Qi Li, 2023, Theranostics.

Recent Development in Studies of Tetrahydroprotoberberines: Mechanism in Antinociception and Drug Addiction

Xuechu Zhen, E. Friedman, Guozhang Jin, 2008, Cellular and Molecular Neurobiology.

Structure-Activity Relationships and Anti-inflammatory Activities of N-Carbamothioylformamide Analogues as MIF Tautomerase Inhibitors

Yu Zhang, Feng Liu, Zhiqiang Zhang, 2015, J. Chem. Inf. Model..

Osteopontin Gene Regulation by Oscillatory Fluid Flow via Intracellular Calcium Mobilization and Activation of Mitogen-activated Protein Kinase in MC3T3–E1 Osteoblasts*

H J Donahue, C R Jacobs, C. Jacobs, 2001, The Journal of Biological Chemistry.

DH5α Outer Membrane-Coated Biomimetic Nanocapsules Deliver Drugs to Brain Metastases but not Normal Brain Cells via Targeting GRP94.

Xuechu Zhen, Lin Wei, Yanming Chen, 2023, Small.

Regulation of Cyclin-Dependent Kinase 5 and Calcium/Calmodulin-Dependent Protein Kinase II by Phosphatidylinositol-Linked Dopamine Receptor in Rat Brain

Xuechu Zhen, K. Bakshi, E. Friedman, 2004, Molecular Pharmacology.

The p38 Mitogen-Activated Protein Kinase Is Involved in Associative Learning in Rabbits

A. Romano, J. Harvey, Xuechu Zhen, 2001, The Journal of Neuroscience.

Modulation of Ca2+ signals by phosphatidylinositol‐linked novel D1 dopamine receptor in hippocampal neurons

Fang Wang, Xuechu Zhen, Jian-Guo Chen, 2006, Journal of neurochemistry.

Chronic SKF83959 induced less severe dyskinesia and attenuated L-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

Xuechu Zhen, Liqun Ma, Jian-Guo Chen, 2007, Neuropharmacology.

l-Stepholidine reduced l-DOPA-induced dyskinesia in 6-OHDA-lesioned rat model of Parkinson's disease

Xuechu Zhen, Hai Zhang, Lei-Ping Yu, 2010, Neurobiology of Aging.

Neuroprotective effects of atypical D1 receptor agonist SKF83959 are mediated via D1 receptor‐dependent inhibition of glycogen synthase kinase‐3β and a receptor‐independent anti‐oxidative action

Xuechu Zhen, Zhang-Jin Zhang, G. Jin, 2008, Journal of neurochemistry.

Single dose of morphine produced a prolonged effect on dopamine neuron activities

Xuechu Zhen, Hai Zhang, Die Zhang, 2008, Molecular pain.

Dihydromyricetin exerts a rapid antidepressant-like effect in association with enhancement of BDNF expression and inhibition of neuroinflammation

J. Waddington, Xuechu Zhen, Huicui Yang, 2017, Psychopharmacology.

Macrophage migration inhibitory factor (MIF) inhibitor, Z-590 suppresses cartilage destruction in adjuvant-induced arthritis via inhibition of macrophage inflammatory activation

Xuechu Zhen, L. Zheng, Huicui Yang, 2018, Immunopharmacology and immunotoxicology.

Structural manipulation on the catecholic fragment of dopamine D(1) receptor agonist 1-phenyl-N-methyl-benzazepines.

Xuechu Zhen, Lin Guo, A. Zhang, 2014, European journal of medicinal chemistry.

Sigma-1 receptor-regulated efferocytosis by infiltrating circulating macrophages/microglial cells protects against neuronal impairments and promotes functional recovery in cerebral ischemic stroke

Xuechu Zhen, Huicui Yang, Qi Li, 2023, Theranostics.

Assessing an Ensemble Docking-Based Virtual Screening Strategy for Kinase Targets by Considering Protein Flexibility

Tingjun Hou, Peichen Pan, Huiyong Sun, 2014, J. Chem. Inf. Model..

GSK‐3β inhibitors reverse cocaine‐induced synaptic transmission dysfunction in the nucleus accumbens

Xuechu Zhen, Hui Shen, Zhaoxiang Ren, 2016, Synapse.

Activation of Extracellular Signal-Regulated Protein Kinases Is Associated with a Sensitized Locomotor Response to D2Dopamine Receptor Stimulation in Unilateral 6-Hydroxydopamine-Lesioned Rats

Xuechu Zhen, K. Uryu, G. Cai, 2000, The Journal of Neuroscience.

Morphine‐induced inhibition of Ca2+‐dependent d‐serine release from astrocytes suppresses excitability of GABAergic neurons in the nucleus accumbens

Xuechu Zhen, Lin Guo, Rui Zhao, 2017, Addiction biology.

'Click' D(1) receptor agonists with a 5-HT(1A) receptor pharmacophore producing D(2) receptor activity.

Xuechu Zhen, Hai Zhang, A. Zhang, 2009, Bioorganic & medicinal chemistry.

PSD-95 Interacts with Dopamine D1-Receptor: Functional Implication

Xuechu Zhen, Lingyong Li, Peihua Sun, 2011 .

Activation of phosphatidylinositol-linked D1-like receptors increases spontaneous glutamate release in rat somatosensory cortical neurons in vitro

Xuechu Zhen, Guo-Yuan Hu, G. Hu, 2010, Brain Research.

Prenatal cocaine exposure alters glycogen synthase kinase-3β (GSK3β) pathway in select rabbit brain areas

Xuechu Zhen, E. Friedman, M. Gil, 2003, Neuroscience Letters.

Prenatal Exposure to Cocaine Disrupts D1A Dopamine Receptor Function Via Selective Inhibition of Protein Phosphatase 1 Pathway in Rabbit Frontal Cortex

Xuechu Zhen, Hoau Yan Wang, E. Friedman, 2001, The Journal of Neuroscience.

Inhibition of neuroinflammation by MIF inhibitor 3-({[4-(4-methoxyphenyl)-6-methyl-2-pyrimidinyl]thio}1methyl)benzoic acid (Z-312).

Xuechu Zhen, L. Zheng, Tingjun Hou, 2021, International immunopharmacology.

Design, synthesis, and pharmacological evaluation of novel tetrahydroprotoberberine derivatives: selective inhibitors of dopamine D₁ receptor.

Hualiang Jiang, Hong Liu, Xuechu Zhen, 2012, Bioorganic & medicinal chemistry.

Synthesis of 6-substituted 1-phenylbenzazepines and their dopamine D(1) receptor activities.

Xuechu Zhen, A. Zhang, Jing Zhang, 2008, Bioorganic & medicinal chemistry.

Discovery of 4-benzoylpiperidine and 3-(piperidin-4-yl)benzo[d]isoxazole derivatives as potential and selective GlyT1 inhibitors

Jianhua Shen, Xuechu Zhen, G. Lin, 2015 .

Targeted to neuronal organelles for CNS drug development.

Xuechu Zhen, Z. Ying, Ningning Li, 2023, Advanced drug delivery reviews.

D4 Dopamine Receptor Differentially Regulates Akt/Nuclear Factor-κB and Extracellular Signal-Regulated Kinase Pathways in D4MN9D Cells

Xuechu Zhen, E. Friedman, Jie Zhang, 2001 .

Identifying the core concepts of pharmacology education: A global initiative

Mark J. Hernandez, J. Goldfarb, Xuechu Zhen, 2022, British journal of pharmacology.

Optimization of 6-heterocyclic-2-(1H-pyrazol-1-yl)-N-(pyridin-2-yl)pyrimidin-4-amine as potent adenosine A2A receptor antagonists for the treatment of Parkinson's disease.

Xuechu Zhen, LinLang Li, Xiaohu Zhang, 2014, ACS chemical neuroscience.

Replacement of amide with bioisosteres led to a new series of potent adenosine A2A receptor antagonists.

Xuechu Zhen, Xiaohu Zhang, Haikuo Ma, 2014, Bioorganic & medicinal chemistry letters.

Inhibition of protein tyrosine/mitogen-activated protein kinase phosphatase activity is associated with D2 dopamine receptor supersensitivity in a rat model of Parkinson's disease.

Xuechu Zhen, G. Cai, E. Friedman, 2002, Molecular pharmacology.

Dihydromyricetin protects against cerebral ischemia/reperfusion injury via suppressing microglia-mediated neuroinflammation and activation of ERK1/2-CREB signaling pathway

Xuechu Zhen, L. Zheng, J. Jia, 2017 .

N-Propylnoraporphin-11-O-yl carboxylic esters as potent dopamine D(2) and serotonin 5-HT(1A) receptor dual ligands.

Xuechu Zhen, Zhili Liu, A. Zhang, 2008, Bioorganic & medicinal chemistry.

D1 dopamine receptor agonists mediate activation of p38 mitogen-activated protein kinase and c-Jun amino-terminal kinase by a protein kinase A-dependent mechanism in SK-N-MC human neuroblastoma cells.

Xuechu Zhen, K. Uryu, Hoau Yan Wang, 1998, Molecular pharmacology.

Design, synthesis and evaluation of benzo[a]thieno[3,2-g]quinolizines as novel l-SPD derivatives possessing dopamine D1, D2 and serotonin 5-HT1A multiple action profiles.

Xuechu Zhen, Lin Guo, Haifeng Sun, 2014, Bioorganic & medicinal chemistry.

LLDT-8 protects against cerebral ischemia/reperfusion injury by suppressing post-stroke inflammation.

Xuechu Zhen, Jian Cheng, J. Jia, 2016, Journal of pharmacological sciences.

Recent developments in studies of l-stepholidine and its analogs: chemistry, pharmacology and clinical implications.

Xuechu Zhen, G. Jin, Yushe Yang, 2007, Current medicinal chemistry.

Tetrahydroberberine blocks ATP-sensitive potassium channels in dopamine neurons acutely-dissociated from rat substantia nigra pars compacta

Xuechu Zhen, Qiang Liu, Jie Wu, 2010, Neuropharmacology.

A small molecule antagonist for the Tudor domain of SMN disrupts the interaction between SMN and RNAP II

Xinghua Guo, J. Greenblatt, J. Min, 2022, bioRxiv.

Design and optimization of purine derivatives as in vivo active PDE10A inhibitors.

Xuechu Zhen, Haibin Luo, Yu-Chih Liu, 2017, Bioorganic & medicinal chemistry.

Activation of Phosphatidylinositol-Linked D1-Like Receptor Modulates FGF-2 Expression in Astrocytes via IP3-Dependent Ca2+ Signaling

Xuechu Zhen, F. Ding, X. Gu, 2009, The Journal of Neuroscience.

CaMKKβ-dependent activation of AMP-activated protein kinase is critical to suppressive effects of hydrogen sulfide on neuroinflammation.

Xuechu Zhen, N. Alkayed, Jian Cheng, 2014, Antioxidants & redox signaling.

Translating advances in the molecular basis of schizophrenia into novel cognitive treatment strategies

J. Waddington, Xuechu Zhen, P. Moran, 2017, British journal of pharmacology.

Electrophysiological Effects of SKF83959 on Hippocampal CA1 Pyramidal Neurons: Potential Mechanisms for the Drug's Neuroprotective Effects

G. Hu, Xuechu Zhen, G. Jin, 2010, PloS one.

Inhibition of phosphodiesterase10A attenuates morphine-induced conditioned place preference

Bo Gao, Xuechu Zhen, L. Zheng, 2014, Molecular Brain.

Inhibition of phosphodiesterase 10 A attenuates morphine-induced conditioned place preference

Bo Gao, Xuechu Zhen, L. Zheng, 2016 .

Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.

Kunqian Yu, Lili Xu, Xuechu Zhen, 2015, Bioorganic & medicinal chemistry letters.

SKF83959 suppresses excitatory synaptic transmission in rat hippocampus via a dopamine receptor‐independent mechanism

G. Hu, Shanglin Zhou, Xuechu Zhen, 2011, Journal of neuroscience research.

Arylbenzazepines Are Potent Modulators for the Delayed Rectifier K+ Channel: A Potential Mechanism for Their Neuroprotective Effects

G. Hu, Xuechu Zhen, A. Zhang, 2009, PloS one.