Wei-Chang Fu

发表

Molecular Modeling of the 3D Structure of 5-HT1AR: Discovery of Novel 5-HT1AR Agonists via Dynamic Pharmacophore-Based Virtual Screening

Bo Gao, Hualiang Jiang, Kunqian Yu, 2013, J. Chem. Inf. Model..

The Use of Computational Approaches in the Discovery and Mechanism Study of Opioid Analgesics

Wei-Chang Fu, Bangyi Zhao, Wei Li, 2020, Frontiers in Chemistry.

Discovery of aryl-piperidine derivatives as potential antipsychotic agents using molecular hybridization strategy.

Wei-Chang Fu, Bangyi Zhao, Wei Li, 2020, European journal of medicinal chemistry.

Discovery of an M-Substituted N-Cyclopropylmethyl-7α-phenyl-6,14-endoethanotetrahydronorthebaine as a Selective, Potent, and Orally Active κ-Opioid Receptor Agonist with an Improved Central Nervous System Safety Profile.

Wei-Chang Fu, Wei Li, Lin-qian Yu, 2021, Journal of medicinal chemistry.

Discovery of Potent and Selective Agonists of δ Opioid Receptor by Revisiting the "Message-Address" Concept.

Wei-Chang Fu, Wei Li, Xiaoqin Huang, 2016, ACS medicinal chemistry letters.

Role of A-kinase anchoring protein 95 in the regulation of cytochrome P450 family 19 subfamily A member 1 (CYP19A1) in human ovarian granulosa cells.

Wei-Chang Fu, Bole Zhuang, Yu Gu, 2018, Reproduction, fertility, and development.

Discovery of a highly selective and potent kappa opioid receptor agonist from N-cyclopropylmethyl-7α-phenyl-6,14-endoethano-tetrahydro- northebaines with reduced central nervous system (CNS) side effects navigated by the message-address concept.

Wei Li, Wei-Chang Fu, Deng-Qi Xue, 2019, Journal of medicinal chemistry.

Design, Synthesis and SAR Exploration of Alkyl/PhenylalkylPiperidine Analogues as Novel Highly Potent and Selective MOR Agonists.

Wei-Chang Fu, Chen Zhu, Wei Li, 2020, ACS chemical neuroscience.

The crystal structure of a complex of acetylcholinesterase with a bis-(-)-nor-meptazinol derivative reveals disruption of the catalytic triad.

Yun Tang, J. Sussman, Wei-Chang Fu, 2009, Journal of medicinal chemistry.

The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors.

Wei-Chang Fu, Zhu-Ping Xiao, Tao Ma, 2010, European journal of medicinal chemistry.

The Pharmacological Heterogeneity of Nepenthone Analogs in Conferring Highly Selective and Potent κ-Opioid Agonistic Activities.

Wei-Chang Fu, Yonghui Wang, Wei Li, 2017, ACS chemical neuroscience.

Design, synthesis and biological evaluation of N-phenylalkyl-substituted tramadol derivatives as novel μ opioid receptor ligands

Wei-Chang Fu, Wei Li, Jing-Gen Liu, 2015, Acta Pharmacologica Sinica.

Functional reversal of (−)‐Stepholidine analogues by replacement of benzazepine substructure using the ring‐expansion strategy

Lili Xu, Xuechu Zhen, Wei-Chang Fu, 2016, Chemical biology & drug design.

Design, synthesis and biological activity of novel demethylvancomycin dimers against vancomycin-resistant enterococcus faecalis

Wei-Chang Fu, Hua-Chen Lin, Xun Sun, 2018, Tetrahedron.

Muscarinic acetylcholine receptor antagonists: SAR and optimization of tyrosine ureas.

Dwight M. Morrow, Wei-Chang Fu, H. Sarau, 2008, Bioorganic & medicinal chemistry letters.

Discovery of Novel Indolealkylpiperazine Derivatives as Potent 5-HT1A Receptor Agonists for the Potential Future Treatment of Depression

Wei-Chang Fu, Chen Zhu, Xinwei Li, 2020, Molecules.

SLL-627 Is a Highly Selective and Potent κ Opioid Receptor (KOR) Agonist with an Unexpected Nonreduction in Locomotor Activity.

Wei-Chang Fu, Wei Li, Siyuan Tang, 2022, Journal of medicinal chemistry.

7β-Methyl substituent is a structural locus associated with activity cliff for nepenthone analogues.

Wei-Chang Fu, Wei Li, Deng-Qi Xue, 2018, Bioorganic & medicinal chemistry.

Discovery of a novel Aurora B inhibitor GSK650394 with potent anticancer and anti-aspergillus fumigatus dual efficacies in vitro

Wei-Chang Fu, Jinyu Li, Liyang Du, 2021, Journal of enzyme inhibition and medicinal chemistry.

N,N'-Diarylcyanoguanidines as antagonists of the CXCR2 and CXCR1 chemokine receptors.

J. D. Elliott, Wei-Chang Fu, H. Sarau, 2006, Bioorganic & medicinal chemistry letters.

Theoretical and NMR investigations on the conformations of ( − )-meptazinol hydrochloride in solution

Yun Tang, C. Lau, Lili Xu, 2013 .

Anti-tumor effects of P-LPK-CPT, a peptide-camptothecin conjugate, in colorectal cancer

Yu Wang, Y. Liang, Wei-Chang Fu, 2022, Communications Biology.

3-Arylamino-2H-1,2,4-benzothiadiazin-5-ol 1,1-dioxides as novel and selective CXCR2 antagonists.

Wei-Chang Fu, H. Sarau, J. Foley, 2007, Bioorganic & medicinal chemistry letters.

GPR91, a critical signaling mechanism in modulating pathophysiologic processes in chronic illnesses

Wei-Chang Fu, Jian Wu, B. Wu, 2020, FASEB journal : official publication of the Federation of American Societies for Experimental Biology.

Discovery of 3-((dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)-N-phenylpiperidine-1-carboxamide as novel potent analgesic.

Wei-Chang Fu, Wei Li, Chen Zhu, 2020, European journal of medicinal chemistry.

Pharmacophore-based design and discovery of (−)-meptazinol carbamates as dual modulators of cholinesterase and amyloidogenesis

Wei-Chang Fu, Hong-Zhuan Chen, Z. Xia, 2017, Journal of enzyme inhibition and medicinal chemistry.

Bis-(-)-nor-meptazinols as novel nanomolar cholinesterase inhibitors with high inhibitory potency on amyloid-beta aggregation.

Yun Tang, Wei-Chang Fu, Wei Zhou, 2008, Journal of medicinal chemistry.

Design, synthesis, and biological evaluation of deuterated C-aryl glycoside as a potent and long-acting renal sodium-dependent glucose cotransporter 2 inhibitor for the treatment of type 2 diabetes.

J. Y. Roberge, Wei-Chang Fu, Kun-Jian Peng, 2014, Journal of medicinal chemistry.

Acylphloroglucinol derivatives with ATP citrate lyase inhibitory activities from Syzygium oblatum Wall.

Wei-Chang Fu, A. Hou, Chun Lei, 2021, Phytochemistry.

4-Carbonyl-2,6-dibenzylidenecyclohexanone derivatives as small molecule inhibitors of STAT3 signaling pathway.

Wei-Chang Fu, Shuhua Ma, Chunhua Qiao, 2016, Bioorganic & medicinal chemistry.

Unprecedented citrinin trimer tricitinol B functions as a novel topoisomerase IIα inhibitor.

Wei-Chang Fu, M. Geng, T. Zhu, 2011, Journal of medicinal chemistry.

Sesquiterpenoids with Anti‐MDR Staphylococcus aureus Activities from Ferula ferulioides

Lili Xu, Wei-Chang Fu, S. Gibbons, 2015, Chemistry & biodiversity.

Sesquiterpenoids with anti-MDR Staphylococcus aureus Activities from Ferula ferulioides.

Lili Xu, Wei-Chang Fu, S. Gibbons, 2015 .

Discovery of novel and long acting muscarinic acetylcholine receptor antagonists.

Dwight M. Morrow, Wei-Chang Fu, H. Sarau, 2008, Journal of medicinal chemistry.

Synthesis and biological evaluation of 7-O-modified oroxylin A derivatives.

Wei-Chang Fu, N. Lu, Q. You, 2012, Bioorganic & medicinal chemistry letters.

Modes of action insights from the crystallographic structures of retinoic acid receptor-related orphan receptor-γt (RORγt).

Wei-Chang Fu, Xiaoqin Huang, Wuqing Wang, 2022, European journal of medicinal chemistry.

Discovery of novel N-sulfonamide-tetrahydroquinolines as potent retinoic acid receptor-related orphan receptor γt inverse agonists for the treatment of autoimmune diseases.

Wei-Chang Fu, Yonghui Wang, Chen Zhu, 2019, European journal of medicinal chemistry.

SNX10 (sorting nexin 10) inhibits colorectal cancer initiation and progression by controlling autophagic degradation of SRC

Kutty Selva Nandakumar, Hualiang Jiang, M. Zheng, 2020, Autophagy.

Discovery of carbazole carboxamides as novel RORγt inverse agonists.

Wei-Chang Fu, Yonghui Wang, Ming-cheng Yu, 2018, European journal of medicinal chemistry.

3,5-Disubstituted-indole-7-carboxamides as IKKβ Inhibitors: Optimization of Oral Activity via the C3 Substituent.

J. Boehm, P. Bamborough, Wei-Chang Fu, 2018, ACS medicinal chemistry letters.

Discovery of novel small-molecule Src kinase inhibitors via a kinase-focused druglikeness rule and structure-based virtual screening

Lili Xu, Wei-Chang Fu, Xianfeng Gu, 2014 .

Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism

Wei-Chang Fu, C. Yuan, Jun Xu, 2019, Acta Pharmacologica Sinica.

Highly selective and potent mu opioid ligands by unexpected substituent on morphine skeleton.

Yun Tang, Wei-Chang Fu, Wei Li, 2010, Bioorganic & medicinal chemistry letters.

Design, Synthesis, and Structure-Activity Relationship Studies of Novel Indolyalkylpiperazine Derivatives as Selective 5-HT1A Receptor Agonists

Chen Zhu, Weiqing Peng, Wenli Wang, 2020, J. Chem. Inf. Model..

Design, synthesis, and structure-activity relationship of tropane muscarinic acetylcholine receptor antagonists.

Zehong Wan, Wei-Chang Fu, H. Sarau, 2009, Journal of medicinal chemistry.

Reversal of subtype-selectivity and function by the introduction of a para-benzamidyl substituent to N-cyclopropylmethyl nornepenthone.

Wei-Chang Fu, Wei Li, Qiong Xie, 2023, European journal of medicinal chemistry.

Discovery, Structure-Activity Relationship, and Mechanistic Studies of 1-((3R,4S)-3-((Dimethylamino)methyl)-4-hydroxy-4-(3-methoxyphenyl)piperidin-1-yl)-2-(2,4,5-trifluorophenyl)ethan-1-one as a Novel Potent Analgesic.

Wei-Chang Fu, Wei Li, Xiangguo Meng, 2021, Journal of Medicinal Chemistry.

Design, Synthesis, and Biological Evaluation of Bipyridazine Derivatives as Stimulator of Interferon Genes (STING) Receptor Agonists.

Kaixian Chen, Hualiang Jiang, M. Zheng, 2023, Journal of medicinal chemistry.

Computational Methods for Understanding the Selectivity and Signal Transduction Mechanism of Aminomethyl Tetrahydronaphthalene to Opioid Receptors

Baiyu Chen, Wei-Chang Fu, Wei Li, 2022, Molecules.

Dopamine D1 receptor and serotonin 5-HT1A receptor agonist effects of the natural product (–)-stepholidine: molecular modelling and dynamics simulations

Kaixian Chen, Wei-Chang Fu, Y. Gong, 2012 .

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

Wei-Chang Fu, Wei Li, Peng Du, 2012, The journal of physical chemistry. B.

Exploration of the SAR Connection between Morphinan- and Arylacetamide-Based κ Opioid Receptor (κOR) Agonists Using the Strategy of Bridging.

Wei-Chang Fu, Wei Li, Li-ying Xiao, 2021, ACS chemical neuroscience.

Molecular dynamics simulations on RORγt: insights into its functional agonism and inverse agonism

Wei-Chang Fu, C. Yuan, Nan-nan Sun, 2019, Acta Pharmacologica Sinica.

Molecular insights into the D1R agonist and D2R/D3R antagonist effects of the natural product (-)-stepholidine: molecular modeling and dynamics simulations.

Wei-Chang Fu, Wei Li, Peng Du, 2012, The journal of physical chemistry. B.

Discovery of novel potent and selective ligands for 5-HT2A receptor with quinazoline scaffold.

Kunqian Yu, Lili Xu, Xuechu Zhen, 2015, Bioorganic & medicinal chemistry letters.

The synthesis, structure and activity evaluation of pyrogallol and catechol derivatives as Helicobacter pylori urease inhibitors.

Wei-Chang Fu, Zhu-Ping Xiao, Tao Ma, 2010, European journal of medicinal chemistry.