S. Franchini

发表

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.

A. Prandi, S. Franchini, Leda Ivanova Manasieva, 2012, Journal of medicinal chemistry.

Investigation of the effect of different linker chemotypes on the inhibition of histone deacetylases (HDACs).

G. Rastelli, L. Altucci, S. Franchini, 2020, Bioorganic chemistry.

Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.

A. Prandi, S. Franchini, P. Fossa, 2016, European journal of medicinal chemistry.

Fluorometric detection of protein‐ligand engagement: The case of phosphodiesterase5

M. Giorgi, S. Franchini, P. Fossa, 2018, Journal of pharmaceutical and biomedical analysis.

A Novel Role of Complement: Mice Deficient in the Fifth Component of Complement (C5) Exhibit Impaired Liver Regeneration1

John D Lambris, S. Franchini, J. Lambris, 2001, The Journal of Immunology.

1,3‐Dioxolane‐Based Ligands as Rigid Analogues of Naftopidil: Structure–Affinity/Activity Relationships at α1 and 5‐HT1A Receptors

Silvia Franchini, A. Prandi, S. Franchini, 2009, ChemMedChem.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.

S. Franchini, M. Buccioni, A. Cilia, 2019, European journal of medicinal chemistry.

Novel monoclonal antibodies against mouse C3 interfering with complement activation: description of fine specificity and applications to various immunoassays.

John D Lambris, S. Franchini, J. Lambris, 2004, Molecular immunology.

A role of complement component C5 in liver regeneration

S. Franchini, J. Lambris, D. Mastellos, 2000 .

Pharmacological properties and biochemical mechanisms of μ-opioid receptor ligands might be due to different binding poses: MD Studies.

S. Franchini, L. Basile, S. Guccione, 2020, Future medicinal chemistry.

Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding.

Maria Paola Costi, R. Wade, S. Franchini, 2010, Protein engineering, design & selection : PEDS.

Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands

S. Franchini, M. Buccioni, A. Cilia, 2022, Results in Chemistry.

C3a and C3b Activation Products of the Third Component of Complement (C3) Are Critical for Normal Liver Recovery after Toxic Injury1

John D Lambris, S. Franchini, J. Lambris, 2004, The Journal of Immunology.

Toxic Injury Critical for Normal Liver Recovery after Third Component of Complement (C3) Are C3a and C3b Activation Products of the

S. Franchini, J. Lambris, D. Mastellos, 2004 .

Kinetic Analysis of the Interactions of Complement Receptor 2 (CR2, CD21) with Its Ligands C3d, iC3b, and the EBV Glycoprotein gp350/2201

W. T. Moore, S. Franchini, J. Lambris, 2001, The Journal of Immunology.

Glycoprotein gp350/220 Its Ligands C3d, iC3b, and the EBV Complement Receptor 2 (CR2, CD21) with Kinetic Analysis of the Interactions of

W. T. Moore, S. Franchini, J. Lambris, 2001 .

Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides

S. Franchini, L. Brasili, Sang Kook Lee, 2017, Archives of pharmacal research.

Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

S. Franchini, G. Marucci, M. Buccioni, 2005, Medicinal Chemistry Research.

Further Insights Into the Pharmacology of the Human Trace Amine‐Associated Receptors: Discovery of Novel Ligands for TAAR1 by a Virtual Screening Approach

R. Gainetdinov, S. Franchini, P. Fossa, 2014, Chemical biology & drug design.

Synthesis of Heteroaryl ortho-Phenoxyethylamines via Suzuki Cross-Coupling: Easy Access to New Potential Scaffolds in Medicinal Chemistry

A. Prandi, S. Franchini, Leda Ivanova Manasieva, 2015 .

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Synthesis, structural characterization and biological evaluation of 4′-C-methyl- and phenyl-dioxolane pyrimidine and purine nucleosides

S. Franchini, L. Brasili, L. Jeong, 2016, Archives of Pharmacal Research.

Diastereoselective Synthesis of (1,3‐Dioxan‐4‐yl)pyrimidine and Purin Nucleoside Analogues

S. Franchini, L. Brasili, L. Jeong, 2015 .

Transacetalization of Acetals with Butane-1,2,4-triol Using Cobalt(II) Chloride and Chlorotrimethylsilane

S. Franchini, L. Brasili, C. Sorbi, 2014, Synthesis.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1.

John D Lambris, S. Franchini, J. Lambris, 2003, Blood.

Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline.

S. Franchini, G. Marucci, L. Brasili, 2000, Bioorganic & medicinal chemistry.

Cloning and purification of the rainbow trout fifth component of complement (C5).

W. T. Moore, John D Lambris, S. Franchini, 2000, Developmental and comparative immunology.

Inhibitors of histone deacetylase 6 based on a novel 3-hydroxy-isoxazole zinc binding group

G. Rastelli, L. Altucci, S. Franchini, 2021, Journal of enzyme inhibition and medicinal chemistry.

Cell-Cycle Inhibition by Helicobacter pylori L-Asparaginase

Silvia Franchini, Andrea Casasco, Victor M. Bolanos-Garcia, 2010, PloS one.

Molecular modeling and biological studies show that some μ-opioid receptor agonists might elicit analgesia acting as MMP-9 inhibitors.

S. Franchini, A. Panico, M. Renis, 2019, Future medicinal chemistry.

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study

S. Franchini, E. Cichero, A. Cilia, 2015 .

Correction: Cell-Cycle Inhibition by Helicobacter pylori L-Asparaginase

S. Franchini, L. Chiarelli, M. Savio, 2012, PLoS ONE.

Novel S1R agonists counteracting NMDA excitotoxicity and oxidative stress: A step forward in the discovery of neuroprotective agents.

A. Tesei, S. Franchini, D. Rossi, 2023, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain.

S. Franchini, P. Fossa, E. Cichero, 2018, Future medicinal chemistry.

Discovery of a new series of 5-HT1A receptor agonists.

Silvia Franchini, Paola Fossa, A. Prandi, 2010, Bioorganic & medicinal chemistry letters.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

Identification of a Potent and Selective 5-HT1A Receptor Agonist with In Vitro and In Vivo Antinociceptive Activity

S. Franchini, P. Fossa, E. Cichero, 2020, ACS chemical neuroscience.

Insights into the Structural Conformations of the Tau Protein in Different Aggregation Status

G. Rastelli, S. Franchini, C. Sorbi, 2023, Molecules.

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.

A. Prandi, S. Franchini, P. Fossa, 2014, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.

S. Franchini, Leda Ivanova Manasieva, P. Fossa, 2017, European journal of medicinal chemistry.

1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.

S. Franchini, A. Cilia, A. Newman, 2019, ACS chemical neuroscience.

BS148 Reduces the Aggressiveness of Metastatic Melanoma via Sigma-2 Receptor Targeting

S. Franchini, L. Brasili, C. Imbriano, 2023, International journal of molecular sciences.

A homology modelling-driven study leading to the discovery of the first mouse trace amine-associated receptor 5 (TAAR5) antagonists

R. Gainetdinov, S. Franchini, P. Fossa, 2016 .

Helichrysum stoechas (L.) Moench reduces body weight gain and modulates mood disorders via inhibition of silent information regulator 1 (SIRT1) by arzanol.

S. Franchini, N. Galeotti, P. Governa, 2023, Phytotherapy research : PTR.

Destabilizers of the thymidylate synthase homodimer accelerate its proteasomal degradation and inhibit cancer growth

E. Giovannetti, G. Peters, R. Wade, 2022, eLife.

Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands.

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Discovery of potent pyrrolo-pyrimidine and purine HDAC inhibitors for the treatment of advanced prostate cancer.

G. Rastelli, S. Franchini, C. Imbriano, 2023, European journal of medicinal chemistry.

Novel Dithiolane-Based Ligands Combining Sigma and NMDA Receptor Interactions as Potential Neuroprotective Agents.

S. Franchini, L. Brasili, R. Iacobazzi, 2020, ACS medicinal chemistry letters.

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

S. Franchini, G. Marucci, M. Buccioni, 2001, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

Characterization of factor H-like molecules in rainbow trout

S. Franchini, J. Lambris, G. Sfyroera, 2000 .

Exhaustive CoMFA and CoMSIA analyses around different chemical entities: a ligand-based study exploring the affinity and selectivity profiles of 5-HT1A ligands

S. Franchini, P. Fossa, E. Cichero, 2017, Journal of enzyme inhibition and medicinal chemistry.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.