G. Marucci

G. Marucci, M. Buccioni, F. Amenta, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Design, synthesis, and biological evaluation of pirenzepine analogs bearing a 1,2-cyclohexanediamine and perhydroquinoxaline units in exchange for the piperazine ring as antimuscarinics.

V. Tumiatti, A. Minarini, M. Rosini, 2008, Bioorganic & medicinal chemistry.

New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes.

G. Marucci, M. Buccioni, K. Minneman, 2006, Bioorganic & medicinal chemistry letters.

Receptor chemistry towards the third millennium : proceedings of the 12th Camerino-Noordwijkerhout Symposium Camerino, Italy, 5-9 September 1999

G. Marucci, W. Quaglia, U. Gulini, 2000 .

Endocannabinoid system in Xenopus laevis development: CB1 receptor dynamics.

G. Marucci, O. Carnevali, F. Ghelfi, 2006, FEBS letters.

Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors.

G. Marucci, M. Buccioni, R. Maggio, 2002, Life sciences.

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.

K. Klotz, G. Marucci, M. Buccioni, 2009, Journal of Medicinal Chemistry.

The possible role of the nucleoside adenosine in countering skin aging: A review

G. Marucci, M. Buccioni, R. Volpini, 2022, BioFactors.

Synthesis and antagonistic activity at muscarinic receptor subtypes of some 2-carbonyl derivatives of diphenidol.

M. Recanatini, G. Marucci, P. Angeli, 1999, Bioorganic & medicinal chemistry.

SAR Studies on the Potent and Selective Muscarinic Antagonist 2‐Ethylthio‐2,2‐diphenylacetic Acid N,N‐Diethylaminoethyl Ester

G. Marucci, C. Ghelardini, S. Dei, 1997, Archiv der Pharmazie.

Dialkylaminoalkyl esters of 2,2-diphenyl-2-alkylthioacetic acids: a new class of potent and functionally selective muscarinic antagonists.

G. Marucci, S. Dei, E. Teodori, 1994, Bioorganic & medicinal chemistry.

“Novel and Highly Selective Postsynaptic α-Adrenoreceptor Antagonists: Synthesis and Structure-Activity Relationships of Alkane-Bridged [4-(phenoxyethyl)-1-piperazinyl]-3 (2H)-pyridazinones”.

G. Marucci, G. Strappaghetti, S. Corsano, 1995 .

New pyridazinones: synthesis and correlation between structure and α-blocking activity

G. Marucci, G. Strappaghetti, S. Corsano, 1993 .

New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A 1 adenosine receptor antagonists

K. Klotz, S. Federico, G. Spalluto, 2011 .

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Pharmaceuticals.

Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

S. Franchini, G. Marucci, M. Buccioni, 2005, Medicinal Chemistry Research.

Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.

G. Marucci, M. Buccioni, M. Ferraroni, 2008, Bioorganic & medicinal chemistry.

Design, synthesis, and biological evaluation of prazosin-related derivatives as multipotent compounds.

V. Tumiatti, M. Rosini, C. Melchiorre, 2005, Journal of medicinal chemistry.

Structure-activity relationships in 1,4-benzodioxan-related compounds. 6. Role of the dioxane unit on selectivity for alpha(1)-adrenoreceptor subtypes.

C. Melchiorre, G. Marucci, M. Giannella, 1999, Journal of medicinal chemistry.

Alpha2-adrenoreceptors profile modulation and high antinociceptive activity of (S)-(-)-2-[1-(biphenyl-2-yloxy)ethyl]-4,5-dihydro-1H-imidazole.

G. Marucci, L. Brasili, M. Dontenwill, 2002, Journal of medicinal chemistry.

Structure-activity relationships among novel phenoxybenzamine-related β-chloroethylamines

C. Melchiorre, G. Marucci, M. Buccioni, 2002 .

Adenosine receptor modeling: what does the A2A crystal structure tell us?

G. Marucci, G. Cristalli, D. Dal Ben, 2010, Current topics in medicinal chemistry.

Synthesis and pharmacological characterization of enantiomerically pure muscarinic agonists: difluoromuscarines.

G. Marucci, P. Conti, M. De Amici, 1997, Journal of medicinal chemistry.

Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells.

G. Marucci, M. Buccioni, C. Ghelardini, 2019, Bioorganic chemistry.

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Combined Therapy of A1AR Agonists and A2AAR Antagonists in Neuroinflammation

G. Marucci, M. Buccioni, C. Lambertucci, 2021, Molecules.

Butter oil (ghee) enrichment with aromatic plants: Chemical characterization and effects on fibroblast migration in anin-vitro wound healing model

G. Marucci, M. Buccioni, S. Vittori, 2020 .

Adenosine Receptors as Neuroinflammation Modulators: Role of A1 Agonists and A2A Antagonists

G. Marucci, M. Buccioni, D. Dal Ben, 2020, Cells.

Synthesis and pharmacological evaluation of enantiomerically pure 4-deoxy-4-fluoromuscarines.

G. Marucci, G. Resnati, A. Arnone, 1992, Journal of medicinal chemistry.

New substituted 9-propyladenine derivatives as A2Aadenosine receptor antagonists

K. Klotz, G. Marucci, M. Buccioni, 2015 .

Synthesis and alpha-adrenoceptor blocking activity of the enantiomers of benzyl-(2-chloroethyl)-[2-(2-methoxyphenoxy)-1-methylethyl]amine hydrochloride.

C. Melchiorre, G. Marucci, L. Antolini, 1997, Bioorganic & medicinal chemistry.

Synthesis and alpha-adrenoreceptor blocking properties of phenoxybenzamine-related (2-chloroethyl)-(2,3-dihydrobenzo[1,4]dioxin- 2-ylmethyl)-(2-phenoxyethyl) amines.

C. Melchiorre, G. Marucci, D. Giardiná, 1995, Bioorganic & medicinal chemistry.

Evidence for the Existence of a Specific G Protein‐Coupled Receptor Activated by Guanosine

G. Marucci, M. Buccioni, G. Cristalli, 2011, ChemMedChem.

Antioxidant-conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.

G. Marucci, M. Buccioni, C. Ghelardini, 2019, Journal of medicinal chemistry.

Determination of muscarinic agonist potencies at M1 and M2 muscarinic receptors in a modified pithed rat preparation

G. Marucci, L. Brasili, P. Angeli, 1990, Naunyn-Schmiedeberg's Archives of Pharmacology.

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

G. Marucci, M. Buccioni, D. Dal Ben, 2015, Current medicinal chemistry.

Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.

C. Supuran, G. Marucci, M. Buccioni, 2020, European journal of medicinal chemistry.

Structure-activity relationship at alpha-adrenergic receptors within a series of imidazoline analogues of cirazoline.

S. Franchini, G. Marucci, L. Brasili, 2000, Bioorganic & medicinal chemistry.

A patent review of adenosine A2B receptor antagonists (2016-present)

G. Marucci, M. Buccioni, D. Dal Ben, 2022, Expert opinion on therapeutic patents.

A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

K. Klotz, G. Marucci, M. Buccioni, 2022, Molecules.

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression

G. Marucci, M. Buccioni, C. Ghelardini, 2021, Pharmaceuticals.

New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists.

G. Marucci, M. Buccioni, D. Dal Ben, 2020, Bioorganic & medicinal chemistry letters.

New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

K. Klotz, G. Marucci, M. Buccioni, 2019, Bioorganic chemistry.

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Bioorganic & medicinal chemistry letters.

“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

S. Moro, S. Federico, G. Spalluto, 2023, Pharmaceuticals.

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

G. Marucci, M. Buccioni, G. Santoni, 2011, Analytical biochemistry.

Choline-Containing Phospholipids: Structure-Activity Relationships Versus Therapeutic Applications.

G. Marucci, M. Buccioni, S. Tayebati, 2015, Current medicinal chemistry.

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17

G. Marucci, M. Buccioni, G. Cristalli, 2011, Purinergic Signalling.

Structure-activity relationships in 1,4-benzodioxan-related compounds. 4. Effect of aryl and alkyl substituents at position 3 on alpha-adrenoreceptor blocking activity.

C. Melchiorre, G. Marucci, S. Tayebati, 1993, Journal of medicinal chemistry.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

K. Klotz, G. Marucci, M. Buccioni, 2018, European journal of medicinal chemistry.

The Anti-Inflammatory and Pain-Relieving Effects of AR170, an Adenosine A3 Receptor Agonist, in a Rat Model of Colitis

G. Marucci, C. Ghelardini, E. Lucarini, 2020, Cells.

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

G. Marucci, M. Buccioni, G. Cristalli, 2010, Bioorganic & medicinal chemistry.

Neuropeptide S Receptor: Recent Updates on Nonpeptide Antagonist Discovery

G. Marucci, M. Buccioni, G. Cristalli, 2011, ChemMedChem.

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

C. Müller, G. Marucci, M. Buccioni, 2018, ACS medicinal chemistry letters.

Fragment optimization for GPCRs by molecular dynamics free energy calculations: Probing druggable subpockets of the A2A adenosine receptor binding site

K. Jacobson, P. Matricon, G. Marucci, 2017, Scientific Reports.

3-Arylpiperazinylethyl-1H-pyrrolo[2,3-d]pyrimidine-2,4(3H,7H)-dione derivatives as novel, high-affinity and selective alpha(1)-adrenoceptor ligands.

G. Marucci, A. Cagnotto, L. Salerno, 2006, Bioorganic & medicinal chemistry letters.

High affinity ligands and potent antagonists for the α1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.

G. Marucci, M. Buccioni, K. Minneman, 2014, European journal of medicinal chemistry.

Donepezil in the treatment of Alzheimer's disease

G. Marucci, F. Amenta, M. Moruzzi, 2020 .

Synthesis and structure-activity relationship studies in a series of 2-substituted 1,3-dioxolanes modified at the cationic head.

G. Marucci, L. Brasili, A. Piergentili, 1997, Bioorganic & medicinal chemistry.

Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice.

G. Marucci, M. Buccioni, A. Amici, 2020, Pharmacological research.

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia

K. Klotz, G. Marucci, M. Buccioni, 2019, Journal of neurochemistry.

Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens.

G. Marucci, M. Buccioni, M. Kandhavelu, 2009, European journal of pharmacology.

(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.

C. Melchiorre, G. Marucci, M. Buccioni, 2005, European journal of pharmacology.

Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.

M. Bolognesi, G. Marucci, M. Buccioni, 2016, European journal of medicinal chemistry.

Chiral analogues of (+)-cyclazosin as potent α1B-adrenoceptor selective antagonist.

G. Marucci, M. Buccioni, S. Costanzi, 2018, Bioorganic & medicinal chemistry.

Stereoselectivity at alpha-adrenoreceptor subtypes: observations with the enantiomers of WB 4101 separated through their amides of N-tosyl-(S)-proline.

V. Andrisano, V. Tumiatti, C. Melchiorre, 1992, Chirality.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

4-(4-Fluorobenzoyl)-1-[2-(4-iodo-2,5-dimethoxyphenyl)ethyl]piperidine and its derivatives: synthesis and affinity at 5-HT2A, 5-HT2B and 5-HT2C serotonin receptors

G. Marucci, S. Gessi, P. Borea, 1999 .

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.

A. Prandi, S. Franchini, P. Fossa, 2014, European journal of medicinal chemistry.

Adenosine A2A Receptor Antagonists: New 8‐Substituted 9‐Ethyladenines as Tools for in vivo Rat Models of Parkinson's Disease

K. Klotz, M. Trincavelli, C. Martini, 2009, ChemMedChem.

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.

G. Marucci, M. Buccioni, R. Matucci, 2001, Bioorganic & medicinal chemistry.

1,3-oxathiolane muscarinic ligands modified at the cationic head.

G. Marucci, R. Matucci, S. Dei, 1994, Farmaco.

[4-[[N-(3-chlorophenyl)carbamoyl]oxy]-2-butynyl]-trimethylammonium (McN-A-343)-related compounds. Effect of the butynyl chain inclusion into an aromatic unit on the potency for muscarinic receptors.

A. Cavalli, V. Andrisano, M. Recanatini, 2000, Bioorganic & medicinal chemistry.

Muscarinic subtypes profile modulation within a series of new antagonists, bridged bicyclic derivatives of 2,2-diphenyl-[1,3]-dioxolan-4-ylmethyl-dimethylamine.

G. Marucci, M. Giannella, A. Piergentili, 2003, Bioorganic & medicinal chemistry.

A3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

G. Marucci, M. Buccioni, G. Santoni, 2022, Pharmaceuticals.

Anticancer activity study of A3 adenosine receptor agonists☆

O. Yli-Harja, G. Marucci, M. Buccioni, 2018, Life sciences.

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

K. Klotz, G. Marucci, M. Buccioni, 2014, Biochemical pharmacology.

A 3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

G. Marucci, M. Buccioni, G. Santoni, 2022 .

The Length and Flexibility of the 2‐Substituent of 9‐Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

K. Klotz, G. Marucci, M. Buccioni, 2016, ChemMedChem.

Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS

G. Massolini, G. Marucci, M. Buccioni, 2012, Analytical and Bioanalytical Chemistry.

A2A adenosine receptor and its modulators: overview on a druggable GPCR and on structure-activity relationship analysis and binding requirements of agonists and antagonists.

G. Marucci, G. Cristalli, D. Dal Ben, 2008, Current pharmaceutical design.

2′,3′-O-Substituted ATP derivatives as potent antagonists of purinergic P2X3 receptors and potential analgesic agents

G. Marucci, A. Nistri, D. Dal Ben, 2017, Purinergic Signalling.

1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Frontal affinity chromatography-mass spectrometry useful for characterization of new ligands for GPR17 receptor.

G. Massolini, M. Trincavelli, C. Martini, 2010, Journal of medicinal chemistry.

Adenine-based acyclic nucleotides as novel P2X3 receptor ligands.

G. Marucci, G. Cristalli, S. Vittori, 2009, Journal of medicinal chemistry.

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Expert opinion on therapeutic patents.

14th Camerino-Noordwijkerhout Symposium - Ongoing Progress in Receptor Chemistry

G. Marucci, M. Giannella, G. Giorgioni, 2003 .

Simulation and Comparative Analysis of Different Binding Modes of Non‐nucleoside Agonists at the A2A Adenosine Receptor

G. Marucci, M. Buccioni, C. Lambertucci, 2016, Molecular informatics.

“N,N-diethylaminoethanol and N-methyl-4-piperidinol Esters of 2,2-diphenyl-2-Ethylthioacetic Acid as Potent and Selective Muscarinic Antagonist”.

G. Marucci, S. Dei, E. Teodori, 1993 .

Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands.

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Synthesis, Pharmacological Evaluation and Selectivity Profile of Isomeric 2-Phenyl-2-cyclohexyl-4-((dimethylamino)methyl)-1,3- dithiolane Methiodides as Potent Antimuscarinic Agents.

G. Marucci, L. Brasili, P. Angeli, 1992 .

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

S. Franchini, G. Marucci, M. Buccioni, 2001, Bioorganic & medicinal chemistry letters.

. “Synthesis, Pharmacological “Evaluation and Selectivity Profile of Isomeric 2-Phenyl-2-Cyclohexyl-4-[(Dimethylamino)Methyl]-1,3-Dithiolane Methiodides, as Potent Antimuscarinic Agents”.

G. Marucci, L. Brasili, P. Angeli, 1992 .

Adenosine A2A Receptor Antagonists: New 8‐Substituted 9‐Ethyladenines as Tools for in vivo Rat Models of Parkinson's Disease

K. Klotz, M. Trincavelli, C. Martini, 2009, ChemMedChem.

Levels of polychlorinated biphenyls in fish and shellfish from the Adriatic Sea

P. Conti, G. Marucci, M. Buccioni, 2008, Food additives & contaminants. Part B, Surveillance.

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

G. Marucci, M. Buccioni, D. Dal Ben, 2015, European journal of medicinal chemistry.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

G. Marucci, M. Buccioni, F. Amenta, 2020, Neuropharmacology.

Structure-activity relationships of acetylcholinesterase noncovalent inhibitors based on a polyamine backbone. 2. Role of the substituents on the phenyl ring and nitrogen atoms of caproctamine.

A. Cavalli, V. Andrisano, M. Bartolini, 2003, Journal of medicinal chemistry.