M. Buccioni

发表

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.

A. Prandi, S. Franchini, Leda Ivanova Manasieva, 2012, Journal of medicinal chemistry.

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

G. Marucci, M. Buccioni, D. Dal Ben, 2015, European journal of medicinal chemistry.

Muscarinic subtype affinity and functional activity profile of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)pyrrolidine and 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine derivatives.

G. Marucci, M. Buccioni, R. Matucci, 2005, Biochemical pharmacology.

Molecular Modeling Studies on the Human Neuropeptide S Receptor and Its Antagonists

G. Marucci, M. Buccioni, G. Cristalli, 2010, ChemMedChem.

New sensible method to quantize the intestinal absorption of receptor ligands.

G. Marucci, M. Buccioni, M. Ricciutelli, 2019, Bioorganic & medicinal chemistry.

P2X3 Receptor Ligands: Structural Features and Potential Therapeutic Applications

G. Marucci, M. Buccioni, D. Dal Ben, 2021, Frontiers in Pharmacology.

Levels of polychlorinated biphenyls in fish and shellfish from the Adriatic Sea

P. Conti, G. Marucci, M. Buccioni, 2008, Food additives & contaminants. Part B, Surveillance.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.

S. Franchini, M. Buccioni, A. Cilia, 2019, European journal of medicinal chemistry.

GPR17 receptor modulators and their therapeutic implications: review of recent patents

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Expert opinion on therapeutic patents.

Highly chiral muscarinic ligands: the discovery of (2S,2'R,3'S,5'R)-1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine 3-sulfoxide methyl iodide, a potent, functionally selective, M2 partial agonist.

G. Marucci, M. Buccioni, R. Matucci, 2006, Journal of medicinal chemistry.

Synthesis and cholinergic affinity of diastereomeric and enantiomeric isomers of 1-methyl-2-(2-methyl-1,3-dioxolan-4-yl)- pyrrolidine, 1-methyl-2-(2-methyl-1,3-oxathiolan-5-yl)pyrrolidine and of Their iodomethylates.

M. Buccioni, M. Ferraroni, R. Matucci, 2003, Bioorganic & medicinal chemistry.

The 1,2,4-Triazolo[4,3-a]pyrazin-3-one as a Versatile Scaffold for the Design of Potent Adenosine Human Receptor Antagonists. Structural Investigations to Target the A2A Receptor Subtype.

A. Cavalli, G. Marucci, M. Buccioni, 2017, Journal of medicinal chemistry.

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor

M. Buccioni, D. Dal Ben, C. Lambertucci, 2013, In Silico Pharmacology.

Antiproliferative Evaluation of Isofuranodiene on Breast and Prostate Cancer Cell Lines

G. Marucci, M. Buccioni, F. Maggi, 2014, TheScientificWorldJournal.

Evaluation of adenine as scaffold for the development of novel P2X3 receptor antagonists.

G. Marucci, M. Buccioni, G. Cristalli, 2013, European journal of medicinal chemistry.

Overview on Radiolabel-Free in vitro Assays for GPCRs.

G. Marucci, M. Buccioni, D. Dal Ben, 2016, Mini reviews in medicinal chemistry.

Rapid novel divergent synthesis and muscarinic agonist profile of all four optical isomers of N,N,N-trimethyl(6-methyl-1,4-dioxan-2-yl)methanaminium iodide.

M. Buccioni, R. Matucci, F. Del Bello, 2008, Bioorganic & medicinal chemistry letters.

Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties.

V. Tumiatti, A. Milelli, A. Minarini, 2007, Bioorganic & medicinal chemistry.

Molecular modulation of muscarinic antagonists. Synthesis and affinity profile of 2,2-diphenyl-2-ethylthio-acetic acid esters designed to probe the binding site cavity.

G. Marucci, M. Buccioni, R. Matucci, 2004, Il Farmaco.

Synthesis and antagonistic activity at muscarinic receptor subtypes of some derivatives of diphenidol.

A. Cavalli, M. Recanatini, G. Marucci, 2003, Farmaco.

The G Protein‐Coupled Receptor GPR17: Overview and Update

G. Marucci, M. Buccioni, D. Dal Ben, 2016, ChemMedChem.

Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands

S. Franchini, M. Buccioni, A. Cilia, 2022, Results in Chemistry.

Synthesis and α1-adrenoceptor antagonist activity of tamsulosin analogues.

C. Melchiorre, G. Marucci, M. Buccioni, 2010, European journal of medicinal chemistry.

Synthesis and alpha(1)-adrenoceptor antagonist activity of derivatives and isosters of the furan portion of (+)-cyclazosin.

C. Melchiorre, G. Marucci, M. Buccioni, 2007, Bioorganic & medicinal chemistry.

Efficacy of acetylcholinesterase inhibitors in Alzheimer's disease

G. Marucci, M. Buccioni, F. Amenta, 2020, Neuropharmacology.

Ex‐vivo absorption study of lysine R‐lipoate salt, a new pharmaceutical form of R‐ALA

G. Marucci, M. Buccioni, F. Amenta, 2018, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

New pyrimido[5,4-b]indoles and [1]benzothieno[3,2-d]pyrimidines: high affinity ligands for the alpha(1)-adrenoceptor subtypes.

G. Marucci, M. Buccioni, K. Minneman, 2006, Bioorganic & medicinal chemistry letters.

Deoxamuscaroneoxime derivatives as useful muscarinic agonists to explore the muscarinic subsite: demox, a modulator of orthosteric and allosteric sites at cardiac muscarinic M2 receptors.

G. Marucci, M. Buccioni, R. Maggio, 2002, Life sciences.

Synthesis and biological evaluation of 2-alkynyl-N6-methyl-5'-N-methylcarboxamidoadenosine derivatives as potent and highly selective agonists for the human adenosine A3 receptor.

K. Klotz, G. Marucci, M. Buccioni, 2009, Journal of Medicinal Chemistry.

The possible role of the nucleoside adenosine in countering skin aging: A review

G. Marucci, M. Buccioni, R. Volpini, 2022, BioFactors.

New 9-methyl-8-(4-hydroxyphenyl)adenine derivatives as A 1 adenosine receptor antagonists

K. Klotz, S. Federico, G. Spalluto, 2011 .

Non-Nucleoside Agonists of the Adenosine Receptors: An Overview

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Pharmaceuticals.

Synthesis and Antimuscarinic Activity of Derivatives of 2-Substituted-1,3-Dioxolanes

S. Franchini, G. Marucci, M. Buccioni, 2005, Medicinal Chemistry Research.

Dioxane and oxathiane nuclei: suitable substructures for muscarinic agonists.

M. Buccioni, F. Del Bello, M. Giannella, 2007, Bioorganic & medicinal chemistry.

Muscarinic antagonists with multiple stereocenters: Synthesis, affinity profile and functional activity of isomeric 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine sulfoxide derivatives.

G. Marucci, M. Buccioni, M. Ferraroni, 2008, Bioorganic & medicinal chemistry.

Structure-activity relationships among novel phenoxybenzamine-related β-chloroethylamines

C. Melchiorre, G. Marucci, M. Buccioni, 2002 .

Outstanding insecticidal activity and sublethal effects of Carlina acaulis root essential oil on the housefly, Musca domestica, with insights on its toxicity on human cells.

M. Buccioni, G. Benelli, A. Canale, 2019, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Novel 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives as potent human adenosine A1 and A2A receptor antagonists. Evaluation of their protective effect against β-amyloid-induced neurotoxicity in SH-SY5Y cells.

G. Marucci, M. Buccioni, C. Ghelardini, 2019, Bioorganic chemistry.

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Polar extracts from the berry-like fruits of Hypericum androsaemum L. as a promising ingredient in skin care formulations.

M. Buccioni, E. Damiani, G. Lupidi, 2017, Journal of ethnopharmacology.

Combined Therapy of A1AR Agonists and A2AAR Antagonists in Neuroinflammation

G. Marucci, M. Buccioni, C. Lambertucci, 2021, Molecules.

Butter oil (ghee) enrichment with aromatic plants: Chemical characterization and effects on fibroblast migration in anin-vitro wound healing model

G. Marucci, M. Buccioni, S. Vittori, 2020 .

Adenosine Receptors as Neuroinflammation Modulators: Role of A1 Agonists and A2A Antagonists

G. Marucci, M. Buccioni, D. Dal Ben, 2020, Cells.

Blue honeysuckle fruit (Lonicera caerulea L.) from eastern Russia: phenolic composition, nutritional value and biological activities of its polar extracts.

M. Buccioni, A. Trivisonno, S. Vittori, 2016, Food & function.

8-Bromo-9-alkyl adenine derivatives as tools for developing new adenosine A2A and A2B receptors ligands.

K. Klotz, M. Buccioni, G. Cristalli, 2009, Bioorganic & medicinal chemistry.

New substituted 9-propyladenine derivatives as A2Aadenosine receptor antagonists

K. Klotz, G. Marucci, M. Buccioni, 2015 .

Evidence for the Existence of a Specific G Protein‐Coupled Receptor Activated by Guanosine

G. Marucci, M. Buccioni, G. Cristalli, 2011, ChemMedChem.

Antioxidant-conjugated 1,2,4-Triazolo[4,3-a]pyrazin-3-one Derivatives: Highly Potent and Selective Human A2A Adenosine Receptor Antagonists Possessing Protective Efficacy in Neuropathic Pain.

G. Marucci, M. Buccioni, C. Ghelardini, 2019, Journal of medicinal chemistry.

Medicinal chemistry of P2X receptors: agonists and orthosteric antagonists.

G. Marucci, M. Buccioni, D. Dal Ben, 2015, Current medicinal chemistry.

Discovery of first-in-class multi-target adenosine A2A receptor antagonists-carbonic anhydrase IX and XII inhibitors. 8-Amino-6-aryl-2-phenyl-1,2,4-triazolo [4,3-a]pyrazin-3-one derivatives as new potential antitumor agents.

C. Supuran, G. Marucci, M. Buccioni, 2020, European journal of medicinal chemistry.

A patent review of adenosine A2B receptor antagonists (2016-present)

G. Marucci, M. Buccioni, D. Dal Ben, 2022, Expert opinion on therapeutic patents.

A2A Adenosine Receptor Antagonists: Are Triazolotriazine and Purine Scaffolds Interchangeable?

K. Klotz, G. Marucci, M. Buccioni, 2022, Molecules.

Design and Synthesis of Novel Thiazolo[5,4-d]pyrimidine Derivatives with High Affinity for Both the Adenosine A1 and A2A Receptors, and Efficacy in Animal Models of Depression

G. Marucci, M. Buccioni, C. Ghelardini, 2021, Pharmaceuticals.

New 8-amino-1,2,4-triazolo[4,3-a]pyrazin-3-one derivatives. Evaluation of different moieties on the 6-aryl ring to obtain potent and selective human A2A adenosine receptor antagonists.

G. Marucci, M. Buccioni, D. Dal Ben, 2020, Bioorganic & medicinal chemistry letters.

New A2A adenosine receptor antagonists: a structure-based upside-down interaction in the receptor cavity.

K. Klotz, G. Marucci, M. Buccioni, 2019, Bioorganic chemistry.

Novel human adenosine receptor antagonists based on the 7-amino-thiazolo[5,4-d]pyrimidine scaffold. Structural investigations at the 2-, 5- and 7-positions to enhance affinity and tune selectivity.

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Bioorganic & medicinal chemistry letters.

“Dual Anta-Inhibitors” of the A2A Adenosine Receptor and Casein Kinase CK1delta: Synthesis, Biological Evaluation, and Molecular Modeling Studies

S. Moro, S. Federico, G. Spalluto, 2023, Pharmaceuticals.

Comparison and optimization of transient transfection methods at human astrocytoma cell line 1321N1.

G. Marucci, M. Buccioni, G. Santoni, 2011, Analytical biochemistry.

Choline-Containing Phospholipids: Structure-Activity Relationships Versus Therapeutic Applications.

G. Marucci, M. Buccioni, S. Tayebati, 2015, Current medicinal chemistry.

Innovative functional cAMP assay for studying G protein-coupled receptors: application to the pharmacological characterization of GPR17

G. Marucci, M. Buccioni, G. Cristalli, 2011, Purinergic Signalling.

Structure-activity relationships in 1,4-benzodioxan-related compounds. 8.(1) {2-[2-(4-chlorobenzyloxy)phenoxy]ethyl}-[2-(2,6-dimethoxyphenoxy)ethyl]amine (clopenphendioxan) as a tool to highlight the involvement of alpha1D- and alpha1B-adrenoreceptor subtypes in the regulation of human PC-3 prostate

Mario Giannella, Alessandro Piergentili, Wilma Quaglia, 2005, Journal of medicinal chemistry.

Simulation and comparative analysis of binding modes of nucleoside and non-nucleoside agonists at the A2B adenosine receptor

M. Buccioni, D. Dal Ben, C. Lambertucci, 2013, In Silico Pharmacology.

New potent and selective A1 adenosine receptor antagonists as potential tools for the treatment of gastrointestinal diseases.

K. Klotz, G. Marucci, M. Buccioni, 2018, European journal of medicinal chemistry.

Molecular modeling study on potent and selective adenosine A(3) receptor agonists.

G. Marucci, M. Buccioni, G. Cristalli, 2010, Bioorganic & medicinal chemistry.

Neuropeptide S Receptor: Recent Updates on Nonpeptide Antagonist Discovery

G. Marucci, M. Buccioni, G. Cristalli, 2011, ChemMedChem.

Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.

C. Müller, G. Marucci, M. Buccioni, 2018, ACS medicinal chemistry letters.

High affinity ligands and potent antagonists for the α1D-adrenergic receptor. Novel 3,8-disubstituted [1]benzothieno[3,2-d]pyrimidine derivatives.

G. Marucci, M. Buccioni, K. Minneman, 2014, European journal of medicinal chemistry.

Acetylshikonin isolated from Lithospermum erythrorhizon roots inhibits dihydrofolate reductase and hampers autochthonous mammary carcinogenesis in Δ16HER2 transgenic mice.

G. Marucci, M. Buccioni, A. Amici, 2020, Pharmacological research.

Neuroprotective potential of adenosine A1 receptor partial agonists in experimental models of cerebral ischemia

K. Klotz, G. Marucci, M. Buccioni, 2019, Journal of neurochemistry.

Identification of alpha1-adrenoceptor subtypes involved in contraction of young CD rat epididymal vas deferens.

G. Marucci, M. Buccioni, M. Kandhavelu, 2009, European journal of pharmacology.

(+)-Cyclazosin, a selective alpha1B-adrenoceptor antagonist: functional evaluation in rat and rabbit tissues.

C. Melchiorre, G. Marucci, M. Buccioni, 2005, European journal of pharmacology.

Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.

M. Bolognesi, G. Marucci, M. Buccioni, 2016, European journal of medicinal chemistry.

Chiral analogues of (+)-cyclazosin as potent α1B-adrenoceptor selective antagonist.

G. Marucci, M. Buccioni, S. Costanzi, 2018, Bioorganic & medicinal chemistry.

Discovery of a new series of 5-HT1A receptor agonists.

Silvia Franchini, Paola Fossa, A. Prandi, 2010, Bioorganic & medicinal chemistry letters.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

Structure-based optimization of coumarin hA3 adenosine receptor antagonists.

S. Vilar, L. Santana, E. Uriarte, 2019, Journal of medicinal chemistry.

Structure-activity relationships in 2,2-diphenyl-2-ethylthioacetic acid esters: unexpected agonistic activity in a series of muscarinic antagonists.

G. Marucci, M. Buccioni, R. Matucci, 2001, Bioorganic & medicinal chemistry.

A3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

G. Marucci, M. Buccioni, G. Santoni, 2022, Pharmaceuticals.

Anticancer activity study of A3 adenosine receptor agonists☆

O. Yli-Harja, G. Marucci, M. Buccioni, 2018, Life sciences.

Different efficacy of adenosine and NECA derivatives at the human A3 adenosine receptor: insight into the receptor activation switch.

K. Klotz, G. Marucci, M. Buccioni, 2014, Biochemical pharmacology.

A 3 Adenosine Receptor Antagonists with Nucleoside Structures and Their Anticancer Activity

G. Marucci, M. Buccioni, G. Santoni, 2022 .

The Length and Flexibility of the 2‐Substituent of 9‐Ethyladenine Derivatives Modulate Affinity and Selectivity for the Human A2A Adenosine Receptor

K. Klotz, G. Marucci, M. Buccioni, 2016, ChemMedChem.

8-(2-Furyl)adenine derivatives as A₂A adenosine receptor ligands.

K. Klotz, S. Federico, G. Spalluto, 2013, European journal of medicinal chemistry.

Development of new chromatographic tools based on A2A adenosine receptor subtype for ligand characterization and screening by FAC-MS

G. Massolini, G. Marucci, M. Buccioni, 2012, Analytical and Bioanalytical Chemistry.

1,2,4-Benzothiadiazine derivatives as α1 and 5-HT1A receptor ligands

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Update on novel purinergic P2X3 and P2X2/3 receptor antagonists and their potential therapeutic applications

G. Marucci, M. Buccioni, D. Dal Ben, 2019, Expert opinion on therapeutic patents.

Simulation and Comparative Analysis of Different Binding Modes of Non‐nucleoside Agonists at the A2A Adenosine Receptor

G. Marucci, M. Buccioni, C. Lambertucci, 2016, Molecular informatics.

Benzothiadiazine derivatives as 1 and 5-HT1A receptor ligands.

S. Franchini, G. Marucci, M. Buccioni, 2005 .

Synthesis, absolute configuration and antimuscarinic activity of the enantiomers of [1-(2,2-diphenyl-[1,3]dioxolan-4-yl)-ethyl]-dimethyl-amine.

S. Franchini, G. Marucci, M. Buccioni, 2001, Bioorganic & medicinal chemistry letters.

Purinergic P2X receptors: structural models and analysis of ligand-target interaction.

G. Marucci, M. Buccioni, D. Dal Ben, 2015, European journal of medicinal chemistry.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.