A. Cilia

发表

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.

A. Prandi, S. Franchini, Leda Ivanova Manasieva, 2012, Journal of medicinal chemistry.

The replacement of the 2-methoxy substituent of N-((6,6-diphenyl-1,4-dioxan-2-yl)methyl)-2-(2-methoxyphenoxy)ethan-1-amine improves the selectivity for 5-HT1A receptor over α1-adrenoceptor and D2-like receptor subtypes.

A. Cilia, R. Matucci, G. Vistoli, 2017, European journal of medicinal chemistry.

Effect of different 5‐hydroxytryptamine receptor subtype antagonists on the micturition reflex in rats

A. Cilia, E. Poggesi, A. Leonardi, 2001, BJU international.

N-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) Cyclohexanecarboxamide: A Novel Pre- and Postsynaptic 5-Hydroxytryptamine1A Receptor Antagonist Active on the Lower Urinary Tract

A. Cilia, E. Poggesi, A. Leonardi, 2001 .

N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-(2-nitrophenyl) cyclohexanecarboxamide: a novel pre- and postsynaptic 5-hydroxytryptamine(1A) receptor antagonist active on the lower urinary tract.

A. Cilia, E. Poggesi, A. Leonardi, 2001, The Journal of pharmacology and experimental therapeutics.

Scouting new sigma receptor ligands: Synthesis, pharmacological evaluation and molecular modeling of 1,3-dioxolane-based structures and derivatives.

A. Prandi, S. Franchini, P. Fossa, 2016, European journal of medicinal chemistry.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.

S. Franchini, M. Buccioni, A. Cilia, 2019, European journal of medicinal chemistry.

Differential Effects of the 5-Hydroxytryptamine (5-HT)1A Receptor Inverse Agonists Rec 27/0224 and Rec 27/0074 on Electrophysiological Responses to 5-HT1A Receptor Activation in Rat Dorsal Raphe Nucleus and Hippocampus in Vitro

R. Corradetti, A. Cilia, B. Mlinar, 2005, Journal of Pharmacology and Experimental Therapeutics.

Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands

S. Franchini, M. Buccioni, A. Cilia, 2022, Results in Chemistry.

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

Effect of several 5-hydroxytryptamine(1A) receptor ligands on the micturition reflex in rats: comparison with WAY 100635.

A. Cilia, E. Poggesi, A. Leonardi, 1999, The Journal of pharmacology and experimental therapeutics.

The Versatile 2‐Substituted Imidazoline Nucleus as a Structural Motif of Ligands Directed to the Serotonin 5‐HT1A Receptor

A. Cilia, C. Ghelardini, L. Micheli, 2016, ChemMedChem.

Enantiomeric resolution of [(2,2-diphenyl-1,3-dioxolan-4-yl)methyl](2-phenoxyethyl)amine, a potent α1 and 5-HT1A receptor ligand: an in vitro and computational study

S. Franchini, E. Cichero, A. Cilia, 2015 .

Chemical manipulations on the 1,4-dioxane ring of 5-HT1A receptor agonists lead to antagonists endowed with antitumor activity in prostate cancer cells.

A. Cilia, G. Vistoli, G. Santoni, 2019, European journal of medicinal chemistry.

Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain.

S. Franchini, P. Fossa, E. Cichero, 2018, Future medicinal chemistry.

Synthesis and structure-activity relationships of novel arylpiperazines as potent antagonists of α1-adrenoceptor.

M. Bolognesi, G. Marucci, M. Buccioni, 2016, European journal of medicinal chemistry.

Synthesis and α4β2 nicotinic affinity of unichiral 5-(2-pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes

A. Cilia, M. Pallavicini, G. Vistoli, 2006 .

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.

G. Rastelli, A. Anighoro, A. Cilia, 2015, Bioorganic & medicinal chemistry.

Discovery of a new series of 5-HT1A receptor agonists.

Silvia Franchini, Paola Fossa, A. Prandi, 2010, Bioorganic & medicinal chemistry letters.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.

Quinazoline based α1-adrenoreceptor antagonists with potent antiproliferative activity in human prostate cancer cell lines.

A. Minarini, M. Rosini, M. Naldi, 2017, European journal of medicinal chemistry.

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.

A. Prandi, S. Franchini, P. Fossa, 2014, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.

S. Franchini, Leda Ivanova Manasieva, P. Fossa, 2017, European journal of medicinal chemistry.

Multitarget 1,4-Dioxane Compounds Combining Favorable D2-like and 5-HT1A Receptor Interactions with Potential for the Treatment of Parkinson's Disease or Schizophrenia.

S. Franchini, A. Cilia, A. Newman, 2019, ACS chemical neuroscience.

5-(2-Pyrrolidinyl)oxazolidinones and 2-(2-pyrrolidinyl)benzodioxanes: synthesis of all the stereoisomers and alpha4beta2 nicotinic affinity.

A. Cilia, M. Pallavicini, G. Vistoli, 2009, Bioorganic & medicinal chemistry letters.

Structure–Activity Relationships within a Series of σ1 and σ2 Receptor Ligands: Identification of a σ2 Receptor Agonist (BS148) with Selective Toxicity against Metastatic Melanoma

S. Franchini, P. Fossa, E. Cichero, 2017, ChemMedChem.

(2,2‐Diphenyl‐[1,3]oxathiolan‐5‐ylmethyl)‐(3‐phenyl‐propyl)‐amine: a Potent and Selective 5‐HT1A Receptor Agonist

A. Prandi, S. Franchini, G. Marucci, 2009, ChemMedChem.