L. Pirona

发表

Synthesis, biological evaluation, and docking studies of tetrahydrofuran- cyclopentanone- and cyclopentanol-based ligands acting at adrenergic α₁- and serotonine 5-HT1A receptors.

A. Prandi, S. Franchini, Leda Ivanova Manasieva, 2012, Journal of medicinal chemistry.

Seizure susceptibility and epileptogenesis are decreased in transgenic rats overexpressing neuropeptide Y

G. Sperk, L. Pirona, C. Schwarzer, 2002, Neuroscience.

1,3‐Dioxolane‐Based Ligands as Rigid Analogues of Naftopidil: Structure–Affinity/Activity Relationships at α1 and 5‐HT1A Receptors

Silvia Franchini, A. Prandi, S. Franchini, 2009, ChemMedChem.

1,3-Dioxane as a scaffold for potent and selective 5-HT1AR agonist with in-vivo anxiolytic, anti-depressant and anti-nociceptive activity.

S. Franchini, M. Buccioni, A. Cilia, 2019, European journal of medicinal chemistry.

Effect of the replacement of the o-methoxyphenyl moiety with nitrogen-containing aromatic rings within N-phenyl-piperazine and phenoxy-ethylamine-based 1,3-dioxo/oxathio/dithiolanes as α1 and 5-HT1A receptor ligands

S. Franchini, M. Buccioni, A. Cilia, 2022, Results in Chemistry.

Chronic treatment with desipramine facilitates its effect on extracellular noradrenaline in the rat hippocampus: studies on the role of presynaptic α2-adrenoceptors

M. Gobbi, L. Pirona, R. Samanin, 2000, Naunyn-Schmiedeberg's Archives of Pharmacology.

In vitro binding studies with two hypericum perforatum extracts--hyperforin, hypericin and biapigenin--on 5-HT6, 5-HT7, GABA(A)/benzodiazepine, sigma, NPY-Y1/Y2 receptors and dopamine transporters.

M. Gobbi, L. Pirona, P. Morazzoni, 2001, Pharmacopsychiatry.

Polyamine oxidase activity in lymphoid tissues of glucocorticoid-treated rats.

L. Pirona, M. Ferioli, O. Pinotti, 1999, Biochemical pharmacology.

1,3-Dioxolane-based ligands incorporating a lactam or imide moiety: structure-affinity/activity relationship at alpha1-adrenoceptor subtypes and at 5-HT1A receptors.

Silvia Franchini, Paola Fossa, Elena Cichero, 2010, European journal of medicinal chemistry.

Gender-related differences in polyamine oxidase activity in rat tissues

L. Pirona, O. Pinotti, M. E. Ferioli, 1999, Amino Acids.

p‐Methylthioamphetamine and 1‐(m‐chlorophenyl)piperazine, two non‐neurotoxic 5‐HT releasers in vivo, differ from neurotoxic amphetamine derivatives in their mode of action at 5‐HT nerve endings in vitro

M. Gobbi, L. Pirona, M. Reyes-Parada, 2002, Journal of neurochemistry.

Prolactin and polyamine catabolism: specific effect on polyamine oxidase activity in rat thymus

L. Pirona, O. Pinotti, M. E. Ferioli, 2000, Molecular and Cellular Endocrinology.

Evaluation of Amides, Carbamates, Sulfonamides, and Ureas of 4-Prop-2-ynylidenecycloalkylamine as Potent, Selective, and Bioavailable Negative Allosteric Modulators of Metabotropic Glutamate Receptor 5.

G. Rastelli, L. Pirona, G. Vistoli, 2019, Journal of medicinal chemistry.

Synthesis and biological evaluation of 1,3-dioxolane-based 5-HT1A receptor agonists for CNS disorders and neuropathic pain.

S. Franchini, P. Fossa, E. Cichero, 2018, Future medicinal chemistry.

Potential antidepressant properties of IDN 5491 (hyperforin-trimethoxybenzoate), a semisynthetic ester of hyperforin

M. Gobbi, L. Pirona, A. Riva, 2005, European Neuropsychopharmacology.

Insights into the interaction of negative allosteric modulators with the metabotropic glutamate receptor 5: discovery and computational modeling of a new series of ligands with nanomolar affinity.

G. Rastelli, A. Anighoro, A. Cilia, 2015, Bioorganic & medicinal chemistry.

Structure-affinity/activity relationships of 1,4-dioxa-spiro[4.5]decane based ligands at α1 and 5-HT1A receptors.

A. Prandi, S. Franchini, P. Fossa, 2014, European journal of medicinal chemistry.

Synthesis, biological evaluation and molecular modeling of 1-oxa-4-thiaspiro- and 1,4-dithiaspiro[4.5]decane derivatives as potent and selective 5-HT1A receptor agonists.

S. Franchini, Leda Ivanova Manasieva, P. Fossa, 2017, European journal of medicinal chemistry.