G. Liapakis

发表

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch.

J. Ballesteros, Lei Shi, G. Liapakis, 2002, The Journal of biological chemistry.

J. Ballesteros, G. Liapakis, J. Javitch, 2000, The Journal of Biological Chemistry.

Selective antagonism of CRF1 receptor by a substituted pyrimidine

G. Liapakis, H. Fahmy, A. Margioris, 2019, Hormones.

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6*

J. Ballesteros, Lei Shi, G. Liapakis, 2001, The Journal of Biological Chemistry.

Template-constrained cyclic peptide analogues of somatostatin: subtype-selective binding to somatostatin receptors and antiangiogenic activity.

W. DeGrado, S. Mousa, G. Liapakis, 2000, Bioorganic & medicinal chemistry.

Integration of multi-scale molecular modeling approaches with experiments for the in silico guided design and discovery of novel hERG-Neutral antihypertensive oxazalone and imidazolone derivatives and analysis of their potential restrictive effects on cell proliferation.

G. Liapakis, Y. Ergun, Ismail Erol, 2018, European journal of medicinal chemistry.

Pharmaceutical compositions for antihypertensive treatments: a patent review

G. Liapakis, T. Mavromoustakos, A. Tzakos, 2015, Expert opinion on therapeutic patents.

Rationally designed cyclic analogues of luteinizing hormone-releasing hormone: enhanced enzymatic stability and biological properties.

Theodore V. Tselios, G. Liapakis, T. Katsila, 2012, European journal of medicinal chemistry.

Synthesis of substituted pyrimidines as corticotropin releasing factor (CRF) receptor ligands.

G. Liapakis, H. Fahmy, Bhimanna Kuppast, 2014, European journal of medicinal chemistry.

The “homeostasis hormone” and its CRF1 receptor. From structure to function

G. Liapakis, H. Fahmy, Bhimanna Kuppast, 2012, Hormones.

Drug-Membrane Interactions in the Renin Angiotensin System

Tahsin F. Kellici, G. Liapakis, Z. Cournia, 2019, Series in BioEngineering.

The dynamic properties of angiotensin II type 1 receptor inverse agonists in solution and in the receptor site

Tahsin F. Kellici, G. Liapakis, T. Mavromoustakos, 2016 .

GnRH-Gemcitabine conjugates for the treatment of androgen-independent prostate cancer: pharmacokinetic enhancements combined with targeted drug delivery.

G. Liapakis, K. Morgan, O. Argyros, 2014, Bioconjugate chemistry.

Molecular and Functional Properties of Somatostatin Receptor Subtypes

G. Liapakis, T. Reisine, M. Tallent, 1996 .

Effects of acute and chronic desipramine treatment on somatostatin receptors in brain

G. Liapakis, C. Spyraki, K. Thermos, 2005, Psychopharmacology.

Structural and compositional determinants of cortistatin activity

S. Henriksen, G. Koob, J. Sutcliffe, 1999, Journal of neuroscience research.

Solubilization of active somatostatin receptors from rabbit retina.

G. Liapakis, K. Thermos, E. Politou, 1993, Biochemical pharmacology.

Characterization of [125I]Tyr11-Somatostatin binding sites in the rabbit retina

G. Liapakis, K. Thermos, 1992, Neuropeptides.

G protein-coupled receptor signaling to Kir channels in Xenopus oocytes.

G. Liapakis, J. González-Maeso, D. Logothetis, 2014, Current pharmaceutical biotechnology.

Evidence for downregulation of erythropoietin receptor in bone marrow erythroid cells of patients with chronic idiopathic neutropenia.

G. Liapakis, H. Papadaki, G. Eliopoulos, 2006, Experimental hematology.

Somatostatin receptor subtypes SSTR2 and SSTR5 couple negatively to an L-type Ca2+ current in the pituitary cell line AtT-20

M. Dichter, G. Liapakis, T. Reisine, 1996, Neuroscience.

Obtaining structural and functional information for GPCRs using the substituted-cysteine accessibility method (SCAM).

G. Liapakis, 2014, Current pharmaceutical biotechnology.

Molecular biology of peptide receptors

G. Liapakis, T. Reisine, 1996 .

Exploring new scaffolds for angiotensin II receptor antagonism.

G. Liapakis, A. Detsi, C. Potamitis, 2016, Bioorganic & medicinal chemistry.

Novel long-acting somatostatin analog with endocrine selectivity: potent suppression of growth hormone but not of insulin.

A. Hoffman, O. Ziv, G. Liapakis, 2001, Endocrinology.

Evaluation of a Stable Gonadotropin-Releasing Hormone Analog in Mice for the Treatment of Endocrine Disorders and Prostate Cancer

Theodore V. Tselios, G. Liapakis, N. Kostomitsopoulos, 2011, Journal of Pharmacology and Experimental Therapeutics.

Urocortin III, A Brain Neuropeptide of the Corticotropin‐Releasing Hormone Family: Modulation by Stress and Attenuation of Some Anxiety‐Like Behaviours

T. Graf, G. Liapakis, M. Venihaki, 2004, Journal of neuroendocrinology.

β2 Adrenergic Receptor Activation

J. Ballesteros, Lei Shi, G. Liapakis, 2002, The Journal of Biological Chemistry.

Identification of Ligand Binding Determinants in the Somatostatin Receptor Subtypes 1 and 2*

G. Liapakis, J. Rivier, T. Reisine, 1996, The Journal of Biological Chemistry.

Somatostatin Receptor Subtypes and Regulation of GH Secretion

G. Liapakis, T. Reisine, Gurkeerat Singh, 2000 .

Synthesis of 2-imino and 2-hydrazono thiazolo[4,5-d]pyrimidines as corticotropin releasing factor (CRF) antagonists.

G. Liapakis, H. Fahmy, Bhimanna Kuppast, 2017, European journal of medicinal chemistry.

The Forgotten Serine A CRITICAL ROLE FOR Ser-203 5.42 IN LIGAND BINDING TO AND ACTIVATION OF THE b 2 -ADRENERGIC RECEPTOR*

J. Ballesteros, G. Liapakis, J. Javitch, 2000 .

Lanthionine-somatostatin analogs: synthesis, characterization, biological activity, and enzymatic stability studies.

G. Liapakis, G. Melacini, L. Prokai, 1997, Journal of medicinal chemistry.

Rational design, efficient syntheses and biological evaluation of N,N'-symmetrically bis-substituted butylimidazole analogs as a new class of potent Angiotensin II receptor blockers.

G. Melagraki, A. Afantitis, G. Liapakis, 2013, European journal of medicinal chemistry.

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

G. Liapakis, J. Javitch, Lei Shi, 2002, Methods in enzymology.

Development of bioactive gemcitabine-D-Lys6-GnRH prodrugs with linker-controllable drug release rate and enhanced biopharmaceutical profile.

G. Liapakis, T. Karampelas, C. Tamvakopoulos, 2019, European journal of medicinal chemistry.

Synthesis of New Thiazolo[4,5-d]pyrimidines as Corticotropin Releasing Factor Modulators

G. Liapakis, G. Davies, H. Fahmy, 2015, Medicinal chemistry (Shariqah (United Arab Emirates)).

Corticotrophin-Releasing Factor (CRF) and the Urocortins Are Potent Regulators of the Inflammatory Phenotype of Human and Mouse White Adipocytes and the Differentiation of Mouse 3T3L1 Pre-Adipocytes

G. Liapakis, C. Tsatsanis, E. Dermitzaki, 2014, PloS one.

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

P Ghanouni, G. Liapakis, J. Javitch, 1999, Molecular pharmacology.

Design, Synthesis, Structural Optimization, SAR, in silico Prediction of Physicochemical Properties and Pharmacological Evaluation of Novel & Potent Thiazolo[4,5-d]pyrimidine Corticotropin Releasing Factor (CRF) Receptor Antagonists

G. Liapakis, H. Fahmy, F. Fronczek, 2021, European Journal of Pharmaceutical Sciences.

Alanine Scanning Mutagenesis of the Second Extracellular Loop of Type 1 Corticotropin-Releasing Factor Receptor Revealed Residues Critical for Peptide Binding

G. Liapakis, M. Venihaki, George Deraos, 2009, Molecular Pharmacology.

A Novel Role of Peripheral Corticotropin-Releasing Hormone (CRH) on Dermal Fibroblasts

G. Liapakis, K. Karalis, A. Margioris, 2011, PloS one.

The G-protein coupled receptor family: actors with many faces.

Arnau Cordomí, Leonardo Pardo, George Liapakis, 2012, Current pharmaceutical design.

Current understanding of the structure and function of family B GPCRs to design novel drugs

G. Liapakis, M. Venihaki, G. Kontakis, 2018, Hormones.

Exploring the Binding Site Crevice of a Family B G Protein-Coupled Receptor, the Type 1 Corticotropin Releasing Factor Receptor

G. Liapakis, J. Javitch, K. Gkountelias, 2010, Molecular Pharmacology.

Members of CRF family and their receptors: from past to future.

G. Liapakis, D. Grigoriadis, A. Margioris, 2011, Current medicinal chemistry.

Development of a selective agonist at the somatostatin receptor subtype sstr1.

G. Liapakis, J. Rivier, T. Reisine, 1996, The Journal of pharmacology and experimental therapeutics.

Molecular and functional properties of somatostain receptor subtypes.

G. Liapakis, T. Reisine, M. Tallent, 1996, Metabolism: clinical and experimental.

Analgesic and Anti-Inflammatory Effects of the Synthetic Neurosteroid Analogue BNN27 during CFA-Induced Hyperalgesia

G. Liapakis, M. Venihaki, Smaragda Poulaki, 2021, Biomedicines.

Effects of Cholesterol on GPCR Function: Insights from Computational and Experimental Studies.

G. Liapakis, S. Durdağı, T. Mavromoustakos, 2019, Advances in experimental medicine and biology.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

G. Liapakis, O. Chepurny, G. Holz, 2019, The Journal of Biological Chemistry.

Role of Central and Peripheral CRH in Skin.

G. Liapakis, M. Venihaki, O. Rassouli, 2018, Current molecular pharmacology.

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

G. Liapakis, J. Javitch, Wai Chi Chan, 2004, Molecular pharmacology.

Novel peptidomimetics related to gonadotropin-releasing hormone (GnRH)

L. Rizzi, G. Liapakis, S. Villa, 2015 .

The discovery of new potent non-peptide Angiotensin II AT1 receptor blockers: a concise synthesis, molecular docking studies and biological evaluation of N-substituted 5-butylimidazole derivatives.

G. Liapakis, S. Durdağı, J. Matsoukas, 2012, European journal of medicinal chemistry.

Host-Guest Interactions between Candesartan and Its Prodrug Candesartan Cilexetil in Complex with 2-Hydroxypropyl-β-cyclodextrin: On the Biological Potency for Angiotensin II Antagonism.

G. Liapakis, N. Thomaidis, J. Plavec, 2019, Molecular pharmaceutics.

Synthesis, in vitro biological investigation, and molecular dynamics simulations of thiazolopyrimidine based compounds as corticotrophin releasing factor receptor-1 antagonists.

G. Liapakis, K. Abouzid, O. Chepurny, 2021, Bioorganic chemistry.

Family B G Protein-coupled Receptors and their Ligands: From Structure to Function.

G. Liapakis, T. Mavromoustakos, M. Venihaki, 2017, Current medicinal chemistry.

Structural-Functional Analysis of the Third Transmembrane Domain of the Corticotropin-releasing Factor Type 1 Receptor

L. Pardo, G. Liapakis, D. Logothetis, 2014, The Journal of Biological Chemistry.

Mapping Structural Determinants within Third Intracellular Loop That Direct Signaling Specificity of Type 1 Corticotropin-releasing Hormone Receptor*

G. Liapakis, H. Lehnert, Jiyou Tang, 2012, The Journal of Biological Chemistry.

Discovery of a stable tripeptide targeting the N-domain of CRF1 receptor

Golfo G. Kordopati, G. Liapakis, T. Mavromoustakos, 2020, Amino Acids.

Nonconventional glucagon and GLP-1 receptor agonist and antagonist interplay at the GLP-1 receptor revealed in high-throughput FRET assays for cAMP

G. Liapakis, O. Chepurny, G. Holz, 2019, The Journal of Biological Chemistry.

Novel stable analogues of the neurotensin C-terminal hexapeptide containing unnatural amino acids

G. Liapakis, E. Dermitzaki, A. Margioris, 2019, Amino Acids.