J. Javitch

发表

Beta2 adrenergic receptor activation. Modulation of the proline kink in transmembrane 6 by a rotamer toggle switch.

J. Ballesteros, Lei Shi, G. Liapakis, 2002, The Journal of biological chemistry.

J. Ballesteros, G. Liapakis, J. Javitch, 2000, The Journal of Biological Chemistry.

A cluster of aromatic residues in the sixth membrane-spanning segment of the dopamine D2 receptor is accessible in the binding-site crevice.

J. Ballesteros, H. Weinstein, J. Javitch, 1998, Biochemistry.

The second extracellular loop of the dopamine D2 receptor lines the binding-site crevice.

Lei Shi, J. Javitch, 2004, Proceedings of the National Academy of Sciences of the United States of America.

Signaling pathways in schizophrenia: emerging targets and therapeutic strategies.

J. Lieberman, J. Javitch, R. Girgis, 2010, Trends in pharmacological sciences.

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action.

J. Javitch, S. Ferrando, Z. Freyberg, 2010, The American journal of psychiatry.

Time-resolved FRET between GPCR ligands reveals oligomers in native tissues.

J. Javitch, J. Pin, I. Brabet, 2010, Nature chemical biology.

Structural Basis of Dopamine Receptor Activation

Spencer S. Ericksen, H. Weinstein, I. Moreira, 2010 .

Allosteric communication between protomers of dopamine Class A GPCR dimers modulates activation

Irina S. Moreira, Jonathan A. Javitch, Harel Weinstein, 2009, Nature chemical biology.

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

J. Rothman, J. Javitch, E. Bowton, 2011, Nature Neuroscience.

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog

Jonathan A. Javitch, Harel Weinstein, Lei Shi, 2011, Nature.

PIP2 regulates psychostimulant behaviors through its interaction with a membrane protein

H. Weinstein, H. Sitte, J. Javitch, 2014, Nature chemical biology.

Toward Understanding the Structural Basis of Partial Agonism at the Dopamine D3 Receptor.

J. Deschamps, Lei Shi, J. Javitch, 2017, Journal of medicinal chemistry.

6′-Guanidinonaltrindole (6′-GNTI) Is a G Protein-biased κ-Opioid Receptor Agonist That Inhibits Arrestin Recruitment*

J. Javitch, M. Rives, L. Liu-Chen, 2012, The Journal of Biological Chemistry.

The membrane-raft protein Flotillin-1 is essential in dopamine neurons for amphetamine-induced behavior in Drosophila

Jonathan A. Javitch, Zachary Freyberg, R. Freyberg, 2012, Molecular Psychiatry.

A pincer-like configuration of TM2 in the human dopamine transporter is responsible for indirect effects on cocaine binding

H. Weinstein, Lei Shi, J. Javitch, 2005, Neuropharmacology.

Symmetrical dimer of the human dopamine transporter revealed by cross-linking Cys-306 at the extracellular end of the sixth transmembrane segment

J. Javitch, A. Karlin, H. Hastrup, 2001, Proceedings of the National Academy of Sciences of the United States of America.

The Human Dopamine Transporter Forms a Tetramer in the Plasma Membrane

J. Javitch, N. Sen, H. Hastrup, 2003, Journal of Biological Chemistry.

The binding sites for cocaine and dopamine in the dopamine transporter overlap

H. Weinstein, Lei Shi, J. Javitch, 2008, Nature Neuroscience.

Synthesis and pharmacological evaluation of bivalent tethered ligands to target the mGlu2/4 heterodimeric receptor results in a compound with mGlu2/2 homodimer selectivity.

J. Javitch, C. Lindsley, P. Conn, 2020, Bioorganic & medicinal chemistry letters.

CODA-RET reveals functional selectivity as a result of GPCR heteromerization

J. Javitch, N. Lambert, R. Kolster, 2011, Nature chemical biology.

Development and Antiparkinsonian Activity of VU0418506, a Selective Positive Allosteric Modulator of Metabotropic Glutamate Receptor 4 Homomers without Activity at mGlu2/4 Heteromers.

Anna L. Blobaum, J. Javitch, C. Lindsley, 2016, ACS chemical neuroscience.

The binding site of aminergic G protein-coupled receptors: the transmembrane segments and second extracellular loop.

Lei Shi, Jonathan A Javitch, Lei Shi, 2002, Annual review of pharmacology and toxicology.

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

Eric Teboul, Jonathan A Javitch, Jozsef Meszaros, 2018, Nature Communications.

Reaction of oxidized dopamine with endogenous cysteine residues in the human dopamine transporter

J. B. Justice, J. Javitch, J A Javitch, 2001, Journal of neurochemistry.

Paraquat neurotoxicity is mediated by the dopamine transporter and organic cation transporter-3

J. Javitch, J. Grima, N. Sen, 2011, Proceedings of the National Academy of Sciences.

Activation of the β2-Adrenergic Receptor Involves Disruption of an Ionic Lock between the Cytoplasmic Ends of Transmembrane Segments 3 and 6*

J. Ballesteros, Lei Shi, G. Liapakis, 2001, The Journal of Biological Chemistry.

Mapping the binding-site crevice of the dopamine D2 receptor by the substituted-cysteine accessibility method

Jonathan A Javitch, J. Javitch, A. Karlin, 1995, Neuron.

Crystal structures of LeuT reveal conformational dynamics in the outward-facing states

J. Javitch, Ziyi Sun, M. Quick, 2021, The Journal of biological chemistry.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2019, bioRxiv.

The allosteric mechanism of substrate-specific transport in SLC6 is mediated by a volumetric sensor

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2019, Proceedings of the National Academy of Sciences.

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2018, Nature Communications.

Conformational Dynamics on the Extracellular Side of LeuT Controlled by Na+ and K+ Ions and the Protonation State of Glu290*

H. Weinstein, Lei Shi, J. Javitch, 2016, The Journal of Biological Chemistry.

Conformational dynamics of ligand-dependent alternating access in LeuT

Benoît Roux, Harel Weinstein, Matthias Quick, 2014, Nature Structural &Molecular Biology.

A mechanism for intracellular release of Na+ by neurotransmitter/sodium symporters

J. Javitch, J. Lyons, P. Nissen, 2014, Nature Structural &Molecular Biology.

Crystal structure of a phosphorylation-coupled saccharide transporter

Ming Zhou, Marco Punta, Hua Huang, 2011, Nature.

Binding of an octylglucoside detergent molecule in the second substrate (S2) site of LeuT establishes an inhibitor-bound conformation

Jonathan A. Javitch, Harel Weinstein, Poul Nissen, 2009, Proceedings of the National Academy of Sciences.

The mechanism of a neurotransmitter:sodium symporter--inward release of Na+ and substrate is triggered by substrate in a second binding site.

Harel Weinstein, Lei Shi, Matthias Quick, 2008, Molecular cell.

Mechanism of chloride interaction with neurotransmitter:sodium symporters

Jonathan A. Javitch, Matthias Quick, J. Javitch, 2007, Nature.

A Comprehensive Structure-Based Alignment of Prokaryotic and Eukaryotic Neurotransmitter/Na+ Symporters (NSS) Aids in the Use of the LeuT Structure to Probe NSS Structure and Function

Harel Weinstein, Thijs Beuming, Jonathan A Javitch, 2006, Molecular Pharmacology.

State-dependent Conformations of the Translocation Pathway in the Tyrosine Transporter Tyt1, a Novel Neurotransmitter:Sodium Symporter from Fusobacterium nucleatum*

Harel Weinstein, Lei Shi, Thijs Beuming, 2006, Journal of Biological Chemistry.

In vivo variation in same-day estimates of metabotropic glutamate receptor subtype 5 binding using [11C]ABP688 and [18F]FPEB

Yiyun Huang, R. Parsey, R. Carson, 2017, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Signalling profiles of a structurally diverse panel of synthetic cannabinoid receptor agonists.

M. Glass, J. Javitch, N. Grimsey, 2020, Biochemical pharmacology.

Cannabinoid CB1 and CB2 Receptor-Mediated Arrestin Translocation: Species, Subtype, and Agonist-Dependence

M. Glass, J. Javitch, N. Grimsey, 2019, Front. Pharmacol..

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

J. R. Lane, Lei Shi, J. Javitch, 2022, Communications biology.

The Fourth Transmembrane Segment Forms the Interface of the Dopamine D2 Receptor Homodimer*

Lei Shi, Jonathan A Javitch, Lei Shi, 2003, The Journal of Biological Chemistry.

Discovery and Characterization of a G Protein – Biased Agonist That Inhibits b-Arrestin Recruitment to the D 2 Dopamine Receptor s

M. Ferrer, D. Sibley, Noel Southall, 2014 .

Discovery and Characterization of a G Protein–Biased Agonist That Inhibits β-Arrestin Recruitment to the D2 Dopamine Receptor

M. Ferrer, D. Sibley, Noel Southall, 2014, Molecular Pharmacology.

Hypochondriasis and obsessive compulsive disorder: overlaps in diagnosis and treatment.

E. Hollander, M. Liebowitz, J. Javitch, 1991, The Journal of clinical psychiatry.

The differential actions of clozapine and other antipsychotic drugs on the translocation of dopamine D2 receptors to the cell surface

J. R. Lane, J. Javitch, Dean J Kareemo, 2019, The Journal of Biological Chemistry.

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

J. R. Lane, J. Javitch, S. Charlton, 2018, Nature Communications.

Dopamine Prevents Nitration of Tyrosine Hydroxylase by Peroxynitrite and Nitrogen Dioxide

J. Javitch, D. Kuhn, Samuel Park, 2003, Journal of Biological Chemistry.

Surface Targeting of the Dopamine Transporter Involves Discrete Epitopes in the Distal C Terminus But Does Not Require Canonical PDZ Domain Interactions

J. Javitch, U. Gether, C. Loland, 2004, The Journal of Neuroscience.

Residues in the fifth membrane-spanning segment of the dopamine D2 receptor exposed in the binding-site crevice.

J. Javitch, J. Chen, J A Javitch, 1995, Biochemistry.

Electrostatic and aromatic microdomains within the binding-site crevice of the D2 receptor: contributions of the second membrane-spanning segment.

J. Ballesteros, J. Javitch, J. Chen, 1999, Biochemistry.

Intramolecular cross-linking in a bacterial homolog of mammalian SLC6 neurotransmitter transporters suggests an evolutionary conserved role of transmembrane segments 7 and 8

H. Sitte, J. Javitch, M. Quick, 2005, Neuropharmacology.

Zn2+ site engineering at the oligomeric interface of the dopamine transporter

J. Javitch, U. Gether, H. Hastrup, 2002, FEBS letters.

Finding needles in haystacks

Jonathan A Javitch, J. Javitch, 2004, Nature Biotechnology.

Dual agonist occupancy of AT1-R-α2C-AR heterodimers results in atypical Gs-PKA signaling.

Céline Galés, Marie-Hélène Seguelas, J. Javitch, 2015, Nature chemical biology.

GPCR-mediated β-arrestin activation deconvoluted with single-molecule precision

Daniel S. Terry, Alessandro Borgia, Lei Shi, 2022, Cell.

[3H]MFZ 2-12: a novel radioligand for the dopamine transporter.

J. Javitch, A. Newman, M. Zou, 2001, Bioorganic & medicinal chemistry letters.

Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning

P. Balsam, J. Javitch, C. Kellendonk, 2021, Molecular Psychiatry.

Distinct inactive conformations of the dopamine D2 and D3 receptors correspond to different extents of inverse agonism

Ara M. Abramyan, J. R. Lane, Lei Shi, 2020, eLife.

Distinct antagonist-bound inactive states underlie the divergence in the structures of the dopamine D2 and D3 receptors

Ara M. Abramyan, J. R. Lane, Lei Shi, 2019, bioRxiv.

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

Min Xu, A. Bonci, A. Hoffman, 2018, Nature Communications.

Metabotropic Glutamate Receptor 5 and Glutamate Involvement in Major Depressive Disorder: A Multimodal Imaging Study.

Sophie E. Holmes, R. Carson, N. Nabulsi, 2017, Biological psychiatry. Cognitive neuroscience and neuroimaging.

Illness Phase as a Key Assessment and Intervention Window for Psychosis

Jared X. Van Snellenberg, J. Lieberman, J. Grinband, 2022, Biological psychiatry global open science.

Do toxic synthetic cannabinoid receptor agonists have signature in vitro activity profiles? A case study of AMB-FUBINACA.

M. Glass, J. Javitch, David B. Finlay, 2019, ACS chemical neuroscience.

Amphetamine-induced Dopamine Efflux

J. Javitch, A. Galli, J. Lechleiter, 2003, The Journal of Biological Chemistry.

GPCR-OKB: the G Protein Coupled Receptor Oligomer Knowledge Base

George Khelashvili, Kevin C. Dorff, Jufang Shan, 2010, Bioinform..

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Addiction States

V. Katritch, J. Javitch, J. Pintar, 2021, bioRxiv.

The organic cation transporter-3 is a pivotal modulator of neurodegeneration in the nigrostriatal dopaminergic pathway

N. Ballatori, J. Javitch, S. Przedborski, 2009, Proceedings of the National Academy of Sciences.

Structure of human GABAB receptor in an inactive state

O. Fiehn, J. Frank, V. Slavkovich, 2020, Nature.

NORMAL MPTP BINDING IN PARKINSONIAN SUBSTANTIA NIGRA: EVIDENCE FOR EXTRANEURONAL TOXIN CONVERSION IN HUMAN BRAIN

S. Snyder, G. Uhl, J. Javitch, 1985, The Lancet.

Detecting G protein-coupled receptor complexes in postmortem human brain with proximity ligation assay and a Bayesian classifier

A. Dwork, J. Javitch, Ziyi Sun, 2019, BioTechniques.

How did the neurotransmitter cross the bilayer? A closer view

J. Javitch, M. Quick, M. Sonders, 2005, Current Opinion in Neurobiology.

Dopamine-mediated autocrine inhibitory circuit regulating human insulin secretion in vitro.

J. Javitch, Z. Freyberg, M. Freeby, 2012, Molecular endocrinology.

Delineating the interactions between the cannabinoid CB2 receptor and its regulatory effectors; β‐arrestins and GPCR kinases

M. Glass, J. Javitch, N. Grimsey, 2021, British journal of pharmacology.

Phospho-specific antibodies targeting the amino terminus of the human dopamine transporter

J. Javitch, C. S. Karam, Namita Sen, 2017, Journal of Chemical Neuroanatomy.

Amphetamine-induced behavior requires CaMKII-dependent dopamine transporter phosphorylation

J. Javitch, C. Ma, C. S. Karam, 2014, Molecular Psychiatry.

Regulation of Dopamine Transporter Trafficking by Intracellular Amphetamine

J. Javitch, A. Galli, U. Gether, 2006, Molecular Pharmacology.

MOL #26351 DOPAMINE TRANSPORTER ACTIVITY MEDIATES AMPHETAMINE-INDUCED INHIBITION OF AKT THROUGH A CaMKII-DEPENDENT MECHANISM Y.Wei,

J. Javitch, A. Galli, C. Saunders, 2006 .

Assays for detecting arrestin interaction with GPCRs.

J. Javitch, Wesley B. Asher, M. Hauge Pedersen, 2021, Methods in cell biology.

Detection of antigen interactions ex vivo by proximity ligation assay: endogenous dopamine D2-adenosine A2A receptor complexes in the striatum.

J. Javitch, M. Rives, P. Trifilieff, 2011, BioTechniques.

Hetero-oligomerization of CCR2, CCR5, and CXCR4 and the Protean Effects of “Selective” Antagonists*

M. Parmentier, J. Javitch, J. Springael, 2009, The Journal of Biological Chemistry.

action illuminated through optical monitoring of synaptic vesicles in Drosophila brain.

R. Freyberg, J. Flores, D. Sulzer, 2016 .

G 12 / 13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL 3

D. McEwen, J. Javitch, N. Lambert, 2020 .

Measuring the effects of ketamine on mGluR5 using [18F]FPEB and PET

Sophie E. Holmes, J. Krystal, R. Carson, 2019, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Ribosome-associated vesicles: A dynamic subcompartment of the endoplasmic reticulum in secretory cells

Simon C Watkins, R. Freyberg, J. Frank, 2020, Science Advances.

Distinct inactive conformations of the dopamine D 2 and D 3 receptors correspond 1 to different extents of inverse agonism 2 3 4

Ara M. Abramyan, J. R. Lane, Lei Shi, 2022 .

Expression and characterization of human dopamine D2 receptor in baculovirus-infected insect cells.

J. Javitch, X. Li, J. Kaback, 1994, Journal of receptor research.

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

J. Javitch, J. Pintar, M. Ansonoff, 2020, Nature communications.

7-Hydroxymitragynine Is an Active Metabolite of Mitragynine and a Key Mediator of Its Analgesic Effects

G. Pasternak, J. Javitch, J. Pintar, 2019, ACS central science.

Yohimbine Depresses Excitatory Transmission in BNST and Impairs Extinction of Cocaine Place Preference Through Orexin-Dependent, Norepinephrine-Independent Processes

D. Sheffler, J. Javitch, Heinrich J.G. Matthies, 2012, Neuropsychopharmacology.

A novel luminescence-based β-arrestin recruitment assay for unmodified receptors

J. Javitch, A. Inoue, H. Mancebo, 2021, The Journal of biological chemistry.

A novel luminescence-based β-arrestin membrane recruitment assay for unmodified GPCRs

J. Javitch, A. Inoue, H. Mancebo, 2020, bioRxiv.

Rebuttal from Nevin A. Lambert and Jonathan A. Javitch

J. Javitch, N. Lambert, 2014, The Journal of physiology.

β2 Adrenergic Receptor Activation

J. Ballesteros, Lei Shi, G. Liapakis, 2002, The Journal of Biological Chemistry.

Structure-activity relationships for a novel series of citalopram (1-(3-(dimethylamino)propyl)-1-(4-fluorophenyl)-1,3-dihydroisobenzofuran-5-carbonitrile) analogues at monoamine transporters.

J. Javitch, A. Newman, Yongfang Zhao, 2010, Journal of medicinal chemistry.

The role of kinetic context in apparent biased agonism at GPCRs

Arthur Christopoulos, Patrick M Sexton, Jonathan A Javitch, 2016, Nature Communications.

Differential activity of mGlu7 allosteric modulators provides evidence for mGlu7/8 heterodimers at hippocampal Schaffer collateral-CA1 synapses

Z. Xiang, J. Javitch, C. Lindsley, 2022, The Journal of biological chemistry.

Sensing conformational changes in metabotropic glutamate receptors

J. Javitch, M. Rives, 2013, Proceedings of the National Academy of Sciences.

Mu opioid receptors on hippocampal GABAergic interneurons are critical for the antidepressant effects of tianeptine

R. Hen, J. Javitch, Alexander Z. Harris, 2021, Neuropsychopharmacology.

CrossTalk opposing view: Weighing the evidence for class A GPCR dimers, the jury is still out

J. Javitch, N. Lambert, 2014, The Journal of physiology.

The Forgotten Serine A CRITICAL ROLE FOR Ser-203 5.42 IN LIGAND BINDING TO AND ACTIVATION OF THE b 2 -ADRENERGIC RECEPTOR*

J. Ballesteros, G. Liapakis, J. Javitch, 2000 .

Getting to grips with ammonium

J. Javitch, Yi Wang, 2013, eLife.

has been made by using a fused green fluorescent protein to detect conformational changes in ammonium transport proteins.

J. Javitch, G. Grossmann, C. Ast, 2013 .

Disentangling autoproteolytic cleavage from tethered agonist–dependent activation of the adhesion receptor ADGRL3

Lei Shi, J. Javitch, Kuo-Hao Lee, 2022, The Journal of biological chemistry.

Context-dependent requirement of G protein coupling for Latrophilin-2 in target selection of hippocampal axons

L. Luo, J. Javitch, Huyan Meng, 2022, bioRxiv.

Functional Selectivity and Classical Concepts of Quantitative Pharmacology

Arthur Christopoulos, Jonathan A. Javitch, Bryan L. Roth, 2007, Journal of Pharmacology and Experimental Therapeutics.

Dopamine D2 receptors form higher order oligomers at physiological expression levels

Marta Filizola, Lei Shi, Juan Carlos Mobarec, 2008, The EMBO journal.

Luciferase complementation based-detection of G-protein-coupled receptor activity.

J. Javitch, S. Ferré, Hideaki Yano, 2018, BioTechniques.

Development of a rapid HTRF ® insulin assay

R. Freyberg, J. Javitch, Z. Freyberg, 2017 .

Use of the substituted cysteine accessibility method to study the structure and function of G protein-coupled receptors.

G. Liapakis, J. Javitch, Lei Shi, 2002, Methods in enzymology.

Discovery of a Novel Selective Kappa-Opioid Receptor Agonist Using Crystal Structure-Based Virtual Screening

Jonathan A. Javitch, Marta Filizola, Ana Negri, 2013, J. Chem. Inf. Model..

What Can Crystal Structures of Aminergic Receptors Tell Us about Designing Subtype-Selective Ligands?

Lei Shi, Thijs Beuming, Mayako Michino, 2015, Pharmacological Reviews.

Comparison of the amino acid residues in the sixth transmembrane domains accessible in the binding-site crevices of mu, delta, and kappa opioid receptors.

H. Weinstein, J. Javitch, W. Xu, 2001, Biochemistry.

The conserved cysteine 7.38 residue is differentially accessible in the binding-site crevices of the mu, delta, and kappa opioid receptors.

J. Javitch, W. Xu, P. Huang, 2000, Biochemistry.

The LeuT-fold neurotransmitter:sodium symporter MhsT has two substrate sites

Ara M. Abramyan, H. Weinstein, Lei Shi, 2018, Proceedings of the National Academy of Sciences.

Antipsychotic drug mechanisms: links between therapeutic effects, metabolic side effects and the insulin signaling pathway

J. Lieberman, J. Javitch, R. Girgis, 2008, Molecular Psychiatry.

Human immunodeficiency virus (HIV) infection of human macrophages is increased by dopamine: a bridge between HIV-associated neurologic disorders and drug abuse.

J. Javitch, J. Berman, T. Calderon, 2009, The American journal of pathology.

Novel Analogues of (R)-5-(Methylamino)-5,6-dihydro-4H-imidazo[4,5,1-ij]quinolin-2(1H)-one (Sumanirole) Provide Clues to Dopamine D2/D3 Receptor Agonist Selectivity

D. Sibley, A. Janowsky, Lei Shi, 2016, Journal of medicinal chemistry.

Calmodulin Kinase II Interacts with the Dopamine Transporter C Terminus to Regulate Amphetamine-Induced Reverse Transport

H. Sitte, J. Javitch, R. Colbran, 2006, Neuron.

Chloride binding site of neurotransmitter sodium symporters

H. Weinstein, Lei Shi, J. Javitch, 2013, Proceedings of the National Academy of Sciences.

A new mechanism of allostery in a G protein-coupled receptor dimer

P. Sexton, A. Christopoulos, J. R. Lane, 2014, Nature chemical biology.

International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers

Michel Bouvier, Lakshmi Devi, Jonathan A. Javitch, 2007, Pharmacological Reviews.

Mutation of a highly conserved aspartic acid in the beta2 adrenergic receptor: constitutive activation, structural instability, and conformational rearrangement of transmembrane segment 6.

P Ghanouni, G. Liapakis, J. Javitch, 1999, Molecular pharmacology.

G Protein-coupled Receptor Kinase-2 Constitutively Regulates D2 Dopamine Receptor Expression and Signaling Independently of Receptor Phosphorylation*

D. Sibley, J. Javitch, E. Urizar, 2009, The Journal of Biological Chemistry.

Cortical overgrowth in a preclinical forebrain organoid model of CNTNAP2-associated autism spectrum disorder

Bianca Migliori, Raju Tomer, S. Kushner, 2019, Nature Communications.

Experimental conditions can obscure the second high-affinity site in LeuT

Jonathan A. Javitch, Harel Weinstein, Lei Shi, 2011, Nature Structural &Molecular Biology.

PI3K signaling supports amphetamine-induced dopamine efflux.

J. Javitch, A. Galli, Brandon J. Lute, 2008, Biochemical and biophysical research communications.

PI 3‐kinase regulation of dopamine uptake

J. Javitch, A. Galli, T. Shippenberg, 2002, Journal of neurochemistry.

Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Jonathan A. Javitch, Lei Shi, Raymond C. Stevens, 2010, Science.

Building a new conceptual framework for receptor heteromers.

Michel Bouvier, Graeme Milligan, Jonathan A Javitch, 2009, Nature chemical biology.

Development of novel biosensors to study receptor-mediated activation of the G-protein α subunits Gs and Golf

J. Javitch, S. Ferré, M. Filizola, 2017, The Journal of Biological Chemistry.

Novel Gαs and Gαolf biosensors 1 Development of novel biosensors to study receptor-mediated activation of Gs and Golf

J. Javitch, S. Ferré, M. Filizola, 2017 .

Characterization of a Functional Bacterial Homologue of Sodium-dependent Neurotransmitter Transporters*

J. Javitch, G. Rudnick, T. Beppu, 2003, The Journal of Biological Chemistry.

Peroxynitrite Inactivates the Human Dopamine Transporter by Modification of Cysteine 342: Potential Mechanism of Neurotoxicity in Dopamine Neurons

J. Javitch, J. Ferrer, D. Kuhn, 2002, The Journal of Neuroscience.

The Uptake Inhibitors Cocaine and Benztropine Differentially Alter the Conformation of the Human Dopamine Transporter*

Jonathan A. Javitch, J. Javitch, M. Reith, 2001, The Journal of Biological Chemistry.

A Juxtamembrane Mutation in the N Terminus of the Dopamine Transporter Induces Preference for an Inward-Facing Conformation

R. Neubig, H. Weinstein, Lei Shi, 2009, Molecular Pharmacology.

Intracellular Ca2+ regulates amphetamine-induced dopamine efflux and currents mediated by the human dopamine transporter.

J. Javitch, A. Galli, M. Gnegy, 2004, Molecular pharmacology.

N-Terminal Phosphorylation of the Dopamine Transporter Is Required for Amphetamine-Induced Efflux

J. Javitch, A. Galli, B. Guptaroy, 2004, PLoS biology.

Syntaxin 1A Interaction with the Dopamine Transporter Promotes Amphetamine-Induced Dopamine Efflux

J. Javitch, R. Colbran, E. Bowton, 2008, Molecular Pharmacology.

Amphetamine induces dopamine efflux through a dopamine transporter channel.

Jonathan A Javitch, Randy D Blakely, R. Blakely, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Amphetamine-induced loss of human dopamine transporter activity: an internalization-dependent and cocaine-sensitive mechanism.

J. Javitch, J. Chen, A. Galli, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca2+/Calmodulin-Dependent Kinase II-Dependent Mechanism

J. Javitch, A. Galli, J. Williams, 2007, Molecular Pharmacology.

DOPAMINE TRANSPORTER ACTIVITY MEDIATES AMPHETAMINE-INDUCED INHIBITION OF AKT THROUGH A CaMKII-DEPENDENT MECHANISM

J. Javitch, A. Galli, J. Williams, 2006 .

Encephalopathy-causing mutations in Gβ1 (GNB1) alter regulation of neuronal GIRK channels

J. Javitch, N. Dascal, Sophie Colombo, 2021, iScience.

Corrigendum: Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

J. Rothman, J. Javitch, E. Bowton, 2011 .

Mitogen-Activated Protein Kinase Regulates Dopamine Transporter Surface Expression and Dopamine Transport Capacity

J. Javitch, B. Hope, A. Galli, 2003, The Journal of Neuroscience.

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain

R. Freyberg, J. Flores, D. Sulzer, 2016, Nature Communications.

Controlling opioid receptor functional selectivity by targeting distinct subpockets of the orthosteric site

Samuel T. Slocum, G. Pasternak, B. Roth, 2021, eLife.

Tianeptine, but not fluoxetine, decreases avoidant behavior in a mouse model of early developmental exposure to fluoxetine

J. Javitch, M. Ansorge, J. Gingrich, 2021, Scientific Reports.

Come Fly with Me: an overview of dopamine receptors in Drosophila melanogaster.

J. Javitch, C. S. Karam, Caline S. Karam, 2019, Basic & clinical pharmacology & toxicology.

Amphetamine and Methamphetamine Differentially Affect Dopamine Transporters in Vitro and in Vivo*

J. Javitch, N. Zahniser, Habibeh Khoshbouei, 2009, Journal of Biological Chemistry.

Tuning the Baird aromatic triplet-state energy of cyclooctatetraene to maximize the self-healing mechanism in organic fluorophores

Daniel S. Terry, S. Jockusch, Alessandro Borgia, 2020, Proceedings of the National Academy of Sciences.

Evidence against dopamine D1/D2 receptor heteromers

D. Sibley, J. Javitch, C. Kellendonk, 2014, Molecular Psychiatry.

Single-molecule analysis of ligand efficacy in β2AR-G protein activation

Jonathan A. Javitch, Brian K. Kobilka, Harel Weinstein, 2017, Nature.

Identification of Novel Functionally Selective κ-Opioid Receptor Scaffolds

B. Roth, J. Javitch, M. Rives, 2014, Molecular Pharmacology.

Structure and functional interaction of the extracellular domain of human GABAB receptor GBR2

L. Mosyak, J. Javitch, J. Pin, 2012, Nature Neuroscience.

Oligomerization Domains of G Protein-Coupled Receptors

Jonathan A. Javitch, Marta Filizola, Harel Weinstein, 2005 .

Constitutive Activation of the β2 Adrenergic Receptor Alters the Orientation of Its Sixth Membrane-spanning Segment*

J. Javitch, G Liapakis, J A Javitch, 1997, The Journal of Biological Chemistry.

Residues in the seventh membrane-spanning segment of the dopamine D2 receptor accessible in the binding-site crevice.

J. Ballesteros, H. Weinstein, J. Javitch, 1996, Biochemistry.

Novel Class of Psychedelic Iboga Alkaloids Disrupts Opioid Use

V. Katritch, J. Javitch, J. Pintar, 2021, bioRxiv.

Two allelic isoforms of the serotonin transporter from Schistosoma mansoni display electrogenic transport and high selectivity for serotonin.

Jonathan A Javitch, Vanderlei Rodrigues, S. Amara, 2009, European journal of pharmacology.

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base

Michel Bouvier, Susan R. George, Jonathan A. Javitch, 2007, BMC Bioinformatics.

Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation.

Marta Filizola, Harel Weinstein, Jonathan A Javitch, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Structural mimicry in G protein-coupled receptors: implications of the high-resolution structure of rhodopsin for structure-function analysis of rhodopsin-like receptors.

J. Ballesteros, J. Javitch, Lei Shi, 2001, Molecular pharmacology.

G12/13 is activated by acute tethered agonist exposure in the adhesion GPCR ADGRL3

D. McEwen, J. Javitch, N. Lambert, 2020, Nature Chemical Biology.

Akt-dependent and isoform-specific regulation of dopamine transporter cell surface expression.

J. Javitch, S. Russo, J. P. Kennedy, 2010, ACS chemical neuroscience.

Transport-dependent Accessibility of a Cytoplasmic Loop Cysteine in the Human Dopamine Transporter*

J. B. Justice, J. Javitch, J A Javitch, 2000, The Journal of Biological Chemistry.

Potentiating SLC transporter activity: Emerging drug discovery opportunities

J. Javitch, M. Rives, A. Wickenden, 2017, Biochemical pharmacology.

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

J. Javitch, M. Filizola, A. Váradi, 2016, Journal of the American Chemical Society.

The Tetrahydroisoquinoline Derivative SB269,652 Is an Allosteric Antagonist at Dopamine D3 and D2 Receptors

Francesca Zazzeroni, Jonathan A. Javitch, Robert R. Luedtke, 2010, Molecular Pharmacology.

The Tetrahydroisoquinoline Derivative SB 269 , 652 Is an Allosteric Antagonist at Dopamine D 3 and D 2 Receptors

M. Millan, J. Javitch, M. Rossi, 2010 .

Cholinergic agonists as novel treatments for schizophrenia: the promise of rational drug development for psychiatry.

J. Lieberman, H. Moore, J. Javitch, 2008, The American journal of psychiatry.

Arrestin recruitment to dopamine D2 receptor mediates locomotion but not incentive motivation

K. Neve, J. R. Lane, J. Javitch, 2018, Molecular Psychiatry.

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

H. Moore, J. R. Lane, J. Javitch, 2017, Nature Communications.

Discovery of β-Arrestin–Biased Dopamine D2 Ligands for Probing Signal Transduction Pathways Essential for Antipsychotic Efficacy

Maria F. Sassano, V. Setola, Xi-Ping Huang, 2011, Proceedings of the National Academy of Sciences.

Characterization of in vivo Pharmacokinetic Properties of the Dopamine D1 Receptor Agonist DAR-0100A in Nonhuman Primates Using PET with [11C] NNC112 and [11C] Raclopride

J. Lieberman, A. Abi-Dargham, M. Slifstein, 2011, Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism.

Exploring the Binding Site Crevice of a Family B G Protein-Coupled Receptor, the Type 1 Corticotropin Releasing Factor Receptor

G. Liapakis, J. Javitch, K. Gkountelias, 2010, Molecular Pharmacology.

Treatment resistant depression: A multi-scale, systems biology approach

H. Akil, R. Hen, J. Gordon, 2018, Neuroscience & Biobehavioral Reviews.

Phosphorylation of the Amino Terminus of the Dopamine Transporter: Regulatory Mechanisms and Implications for Amphetamine Action.

J. Javitch, C. S. Karam, Caline S. Karam, 2018, Advances in pharmacology.

Dysregulation of Dopamine Transporters via Dopamine D2 Autoreceptors Triggers Anomalous Dopamine Efflux Associated with Attention-Deficit Hyperactivity Disorder

R. Blakely, M. Caron, J. Javitch, 2010, The Journal of Neuroscience.

Currents in Response to Rapid Concentration Jumps of Amphetamine Uncover Novel Aspects of Human Dopamine Transporter Function

J. Javitch, A. Galli, K. Erreger, 2008, The Journal of Neuroscience.

Akt Is Essential for Insulin Modulation of Amphetamine-Induced Human Dopamine Transporter Cell-Surface Redistribution

J. Javitch, A. Galli, J. Morón, 2005, Molecular Pharmacology.

Amphetamine Regulation of Dopamine Transport

J. Javitch, A. Galli, Kristopher M. Kahlig, 2004, Journal of Biological Chemistry.

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor

R. Hen, J. Javitch, J. Pintar, 2017, Neuropsychopharmacology.

Impact of membrane lipid polyunsaturation on dopamine D2 receptor ligand binding and signaling

I. Alves, J. Javitch, S. Mongrand, 2022, bioRxiv.

Cocaine increases dopamine uptake and cell surface expression of dopamine transporters.

J. Javitch, L. Daws, A. Galli, 2002, Biochemical and biophysical research communications.

Dopamine D1R Receptor Stimulation as a Mechanistic Pro-cognitive Target for Schizophrenia.

Jared X. Van Snellenberg, J. Grinband, R. Gur, 2021, Schizophrenia bulletin.

Site selective C–H functionalization of Mitragyna alkaloids reveals a molecular switch for tuning opioid receptor signaling efficacy

J. Javitch, J. Pintar, M. Ansonoff, 2021, Nature Communications.

A novel mitragynine analog with low efficacy mu-opioid receptor agonism displays antinociception with attenuated adverse effects

Elyssa B. Margolis, B. Roth, J. Javitch, 2021, bioRxiv.

THE BINDING SITE OF AMINERGIC GP ROTEIN-COUPLED RECEPTORS:

Lei Shi, J. Javitch, 2002 .

A cysteine residue in the third membrane-spanning segment of the human D2 dopamine receptor is exposed in the binding-site crevice.

J. Javitch, X. Li, J. Kaback, 1994, Proceedings of the National Academy of Sciences of the United States of America.

OZITX, a pertussis toxin-like protein for occluding inhibitory G protein signalling including Gαz

J. R. Lane, Lei Shi, J. Javitch, 2022, Communications Biology.

Probing structure of neurotransmitter transporters by substituted-cysteine accessibility method.

J. Javitch, 1998, Methods in enzymology.

Dopamine D4/D2 receptor selectivity is determined by A divergent aromatic microdomain contained within the second, third, and seventh membrane-spanning segments.

J. Ballesteros, L. Snyder, J. Javitch, 1999, Molecular pharmacology.

Membrane composition influences the conformation and function of the dopamine transporter in vivo

J. Javitch, E. Mosharov, Ai Yamamoto, 2019, bioRxiv.

New roles for dopamine D2 and D3 receptors in pancreatic beta cell insulin secretion

D. Sibley, H. Moore, R. Freyberg, 2018, Molecular Psychiatry.

Small Flies Meet Big Data: Genetic Convergence of Neurodevelopmental Disorders Modeled in Drosophila.

J. Javitch, C. S. Karam, Lilian A Coie, 2020, The American journal of psychiatry.

The Ants Go Marching Two by Two: Oligomeric Structure of G-Protein-Coupled Receptors

Jonathan A Javitch, J. Javitch, 2004, Molecular Pharmacology.

The respiratory depressant effects of mitragynine are limited by its conversion to 7‐OH mitragynine

J. R. Lane, J. Javitch, M. Canals, 2022, British journal of pharmacology.

Single-molecule FRET imaging of GPCR dimers in living cells

Daniel S. Terry, K. Jaqaman, J. Javitch, 2021, Nature Methods.

Gs- versus Golf-dependent functional selectivity mediated by the dopamine D1 receptor

A. Bonci, A. Hoffman, Lei Shi, 2018, Nature Communications.

Agonist-induced formation of unproductive receptor-G12 complexes

J. Javitch, N. Lambert, A. Inoue, 2020, Proceedings of the National Academy of Sciences.

Presynaptic regulation of dopamine transmission in schizophrenia.

J. Lieberman, H. Moore, A. Abi-Dargham, 2011, Schizophrenia bulletin.

Cyanine fluorophore derivatives with enhanced photostability

Jonathan A Javitch, Peter Geggier, Daniel S. Terry, 2011, Nature Methods.

Single-molecule dynamics of gating in a neurotransmitter transporter homolog

Jonathan A. Javitch, Harel Weinstein, Lei Shi, 2010, Nature.

Mutation of Three Residues in the Third Intracellular Loop of the Dopamine D2 Receptor Creates an Internalization-defective Receptor*

K. Neve, J. Javitch, N. Lambert, 2014, The Journal of Biological Chemistry.

Increasing dopamine D2 receptor expression in the adult nucleus accumbens enhances motivation

Ryan D Ward, P. Balsam, H. Moore, 2013, Molecular Psychiatry.

D2 Receptors Regulate Dopamine Transporter Function via an Extracellular Signal-Regulated Kinases 1 and 2-Dependent and Phosphoinositide 3 Kinase-Independent Mechanism

J. Javitch, A. Zapata, T. Shippenberg, 2007, Molecular Pharmacology.

The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila

J. Javitch, C. S. Karam, Sandra K Jones, 2021, Neurochemical Research.

The Role of the Dopamine Transporter in the Effects of Amphetamine on Sleep and Sleep Architecture in Drosophila

J. Javitch, C. S. Karam, Caline S. Karam, 2021, Neurochemical Research.

Role of Tau Protein in Remodeling of Circadian Neuronal Circuits and Sleep

J. Javitch, C. S. Karam, I. Santa-Maria, 2019, Front. Aging Neurosci..

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT

R. Freyberg, J. Flores, D. Sulzer, 2017, Neuron.

Structure of human GABAB receptor in an inactive state

O. Fiehn, J. Frank, V. Slavkovich, 2020, Nature.

How changes in dopamine D2 receptor levels alter striatal circuit function and motivation

P. Balsam, J. Javitch, E. Simpson, 2021, Molecular Psychiatry.

Dopamine D2 Receptors in the Paraventricular Thalamus Attenuate Cocaine Locomotor Sensitization

P. Balsam, J. Javitch, C. Kellendonk, 2017, eNeuro.

Impact of D2 Receptor Internalization on Binding Affinity of Neuroimaging Radiotracers

Mark Slifstein, Marc Laruelle, Man Jiang, 2010, Neuropsychopharmacology.

Conformational Plasticity of GPCR Binding Sites

L. Pardo, J. Ballesteros, Lei Shi, 2005 .

Synergistic contributions of the functional groups of epinephrine to its affinity and efficacy at the beta2 adrenergic receptor.

G. Liapakis, J. Javitch, Wai Chi Chan, 2004, Molecular pharmacology.

Development of a Rapid Insulin Assay by Homogenous Time-Resolved Fluorescence

R. Freyberg, J. Javitch, Z. Freyberg, 2016, PloS one.

Sodium-dependent neurotransmitter transporters: oligomerization as a determinant of transporter function and trafficking.

H. Sitte, J. Javitch, H. Farhan, 2004, Molecular interventions.

Novel Fluorescent Ligands Enable Single-Molecule Localization Microscopy of the Dopamine Transporter.

J. Javitch, Brian T DeVree, J. Grimm, 2020, ACS chemical neuroscience.

Chloroethylclonidine and 2-Aminoethyl Methanethiosulfonate Recognize Two Different Conformations of the Human α2A-Adrenergic Receptor*

M. Scheinin, J. Javitch, T. Salminen, 1999, The Journal of Biological Chemistry.

Quantifying secondary transport at single-molecule resolution

Jonathan A. Javitch, Matthias Quick, Scott C. Blanchard, 2019, Nature.

Identification of Intracellular Residues in the Dopamine Transporter Critical for Regulation of Transporter Conformation and Cocaine Binding*

Jonathan A Javitch, Ulrik Gether, J. Javitch, 2004, Journal of Biological Chemistry.

Monitoring the function of membrane transport proteins in detergent-solubilized form

J. Javitch, M. Quick, 2007, Proceedings of the National Academy of Sciences.

Using Bioluminescence Resonance Energy Transfer (BRET) to Characterize Agonist‐Induced Arrestin Recruitment to Modified and Unmodified G Protein‐Coupled Receptors

J. Javitch, N. Lambert, V. Gurevich, 2015, Current protocols in pharmacology.

Dopamine D2 receptor overexpression in the nucleus accumbens core induces robust weight loss during scheduled fasting selectively in female mice

Jie Zhang, J. Javitch, C. Kellendonk, 2019, Molecular Psychiatry.

Accumbens dopamine D2 receptors increase motivation by decreasing inhibitory transmission to the ventral pallidum

H. Moore, J. Javitch, C. Kellendonk, 2018, Nature Communications.

Input-specific regulation of glutamatergic synaptic transmission in the medial prefrontal cortex by mGlu2/mGlu4 receptor heterodimers

Z. Xiang, J. Javitch, C. Lindsley, 2021, Science Signaling.

Upregulation of Dopamine D2 Receptors in the Nucleus Accumbens Indirect Pathway Increases Locomotion but Does Not Reduce Alcohol Consumption

J. Javitch, C. Kellendonk, N. Harrison, 2015, Neuropsychopharmacology.

N-terminal Truncation of the Dopamine Transporter Abolishes Phorbol Ester- and Substance P Receptor-stimulated Phosphorylation without Impairing Transporter Internalization*

J. Javitch, U. Gether, C. Loland, 2003, The Journal of Biological Chemistry.

Extrapyramidal side effects of antipsychotics are linked to their association kinetics at dopamine D2 receptors

H. Moore, J. R. Lane, J. Javitch, 2017, Nature Communications.

New phosphosite-specific antibodies to unravel the role of GRK phosphorylation in dopamine D2 receptor regulation and signaling

J. Javitch, S. Schulz, M. Canals, 2021, Scientific Reports.

Molecular determinants of the intrinsic efficacy of the antipsychotic aripiprazole.

A. Christopoulos, J. R. Lane, Lei Shi, 2019, ACS chemical biology.

A Single Glycine in Extracellular Loop 1 Is the Critical Determinant for Pharmacological Specificity of Dopamine D2 and D3 Receptors

Lei Shi, J. Javitch, M. Michino, 2013, Molecular Pharmacology.

Molecular determinants of selectivity and efficacy at the dopamine D3 receptor.

Lei Shi, J. Javitch, M. Michino, 2012, Journal of medicinal chemistry.

A non‐helical region in transmembrane helix 6 of hydrophobic amino acid transporter MhsT mediates substrate recognition

J. Javitch, J. Lyons, P. Nissen, 2020, The EMBO journal.

X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2020, Nature Communications.

Dopamine Receptor Activation Increases HIV Entry into Primary Human Macrophages

J. Javitch, J. Berman, G. Kalpana, 2014, PloS one.

The Membrane Protein LeuT in Micellar Systems: Aggregation Dynamics and Detergent Binding to the S2 Site

George Khelashvili, Jonathan A. Javitch, Harel Weinstein, 2013, Journal of the American Chemical Society.

The Substrate-Driven Transition to an Inward-Facing Conformation in the Functional Mechanism of the Dopamine Transporter

H. Weinstein, Lei Shi, J. Javitch, 2011, PloS one.

An Intracellular Interaction Network Regulates Conformational Transitions in the Dopamine Transporter*

Harel Weinstein, Lei Shi, Jonathan A Javitch, 2008, Journal of Biological Chemistry.

Cocaine alters the accessibility of endogenous cysteines in putative extracellular and intracellular loops of the human dopamine transporter.

J. Javitch, J. Ferrer, 1998, Proceedings of the National Academy of Sciences of the United States of America.

The action of a negative allosteric modulator at the dopamine D2 receptor is dependent upon sodium ions

Ara M. Abramyan, A. Christopoulos, Lei Shi, 2018, Scientific Reports.

Imaging the high-affinity state of the dopamine D2 receptor in vivo: fact or fiction?

Jonathan A Javitch, Anissa Abi-Dargham, Mette Skinbjerg, 2012, Biochemical pharmacology.

G Protein-coupled Receptor Kinase-mediated Phosphorylation Regulates Post-endocytic Trafficking of the D2 Dopamine Receptor*

Jonathan A Javitch, D. Sibley, J. Javitch, 2009, Journal of Biological Chemistry.

G Protein-coupled Receptor Kinase-mediated Phosphorylation Regulates Post-endocytic Trafficking of the D 2 Dopamine Receptor *

D. Sibley, J. Javitch, Y. Namkung, 2009 .

Extreme Vetting of Dopamine Receptor Oligomerization

J. Javitch, N. Lambert, Steven G. Grinnell, 2017 .

A Structural Context for Studying Neurotransmitter Transporter Function

H. Weinstein, J. Javitch, T. Beuming, 2004 .

Optical Control of Dopamine Receptors Using a Photoswitchable Tethered Inverse Agonist.

E. Isacoff, D. Trauner, J. Javitch, 2017, Journal of the American Chemical Society.

Functional Genomic Analysis of Amphetamine Sensitivity in Drosophila

J. Javitch, D. Goldman, C. S. Karam, 2022, Frontiers in Psychiatry.

Ion/substrate-dependent conformational dynamics of a bacterial homolog of neurotransmitter:sodium symporters

Harel Weinstein, Lei Shi, Matthias Quick, 2010, Nature Structural &Molecular Biology.

Regional Heterogeneity of D2-Receptor Signaling in the Dorsal Striatum and Nucleus Accumbens

Pamela F. Marcott, J. Javitch, L. Birnbaumer, 2018, Neuron.

Reply to ‘Antipsychotics with similar association kinetics at dopamine D2 receptors differ in extrapyramidal side-effects’

J. R. Lane, J. Javitch, S. Charlton, 2018, Nature Communications.

Making Structural Sense of Dimerization Interfaces of Delta Opioid Receptor Homodimers

Davide Provasi, Jonathan A. Javitch, Marta Filizola, 2011, Biochemistry.

Disrupting D1-NMDA or D2-NMDA receptor heteromerization prevents cocaine’s rewarding effects but preserves natural reward processing

J. Caboche, J. Javitch, A. Bemelmans, 2021, Science advances.

Mechanisms of inverse agonism of antipsychotic drugs at the D2 dopamine receptor: use of a mutant D2 dopamine receptor that adopts the activated conformation

J. Javitch, P. Strange, D. Fu, 2001, Journal of neurochemistry.

Free fatty acid receptor 1 stimulates cAMP production and gut hormone secretion through Gq-mediated activation of adenylate cyclase 2

J. Javitch, M. S. Engelstoft, T. Arora, 2023, Molecular metabolism.

The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist

J. Javitch, M. Rives, D. Sames, 2014, Translational Psychiatry.

Segregation of Family A G Protein–Coupled Receptor Protomers in the Plasma Membrane

T. Lan, J. Javitch, N. Lambert, 2013, Molecular Pharmacology.

A partially-open inward-facing intermediate conformation of LeuT is associated with Na+ release and substrate transport

Michael V. LeVine, Daniel S. Terry, H. Weinstein, 2018, Nature Communications.

Chemokine receptors hetero-oligomerization 1 Hetero-oligomerization of CCR 2 , CCR 5 and CXCR 4 and the protean effects of “ selective ”-antagonists

M. Parmentier, J. Javitch, J. Springael, 2009 .

Regulation of Dopamine Transporter Function and Cell Surface Expression by D3 Dopamine Receptors*

J. Javitch, A. Zapata, T. Shippenberg, 2007, Journal of Biological Chemistry.

Differential visualization of dopamine D2 and D3 receptors in rat brain.

J. Javitch, M. Stanley, B. Parsons, 1993, European journal of pharmacology.

Crystal structure of a potassium ion transporter TrkH

B. Rost, J. Javitch, M. Punta, 2010, Nature.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

Jonathan A. Javitch, Ravi Kumar Verma, Ara M. Abramyan, 2018, PLoS Comput. Biol..

Detection of G Protein‐Coupled Receptor Complexes in Postmortem Human Brain by Proximity Ligation Assay

A. Dwork, J. Javitch, P. Trifilieff, 2020, Current protocols in neuroscience.

Dopamine D2 receptors modulate the cholinergic pause and inhibitory learning

P. Balsam, J. Javitch, C. Kellendonk, 2020, bioRxiv.

The first transmembrane segment of the dopamine D2 receptor: accessibility in the binding-site crevice and position in the transmembrane bundle.

J. Ballesteros, J. Javitch, Lei Shi, 2000, Biochemistry.

Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse

J. Javitch, C. Kellendonk, P. Trifilieff, 2015, The Journal of comparative neurology.

Recruitment of β-arrestin2 to the dopamine D2 receptor: Insights into anti-psychotic and anti-parkinsonian drug receptor signaling

J. Javitch, U. Gether, E. Urizar, 2008, Neuropharmacology.

The E2.65A mutation disrupts dynamic binding poses of SB269652 at the dopamine D2 and D3 receptors

Ara M. Abramyan, D. Sibley, J. R. Lane, 2018, PLoS Comput. Biol..

Differentiating dopamine D2 ligands by their sensitivities to modification of the cysteine exposed in the binding-site crevice.

J. Javitch, J. Chen, J A Javitch, 1996, Molecular pharmacology.

Genetically Targeted Optical Control of an Endogenous G Protein-Coupled Receptor.

E. Isacoff, D. Trauner, J. Javitch, 2019, Journal of the American Chemical Society.

Role of Annular Lipids in the Functional Properties of Leucine Transporter LeuT Proteomicelles

Michael V. LeVine, H. Weinstein, Lei Shi, 2016, Biochemistry.

CHAPTER 26 – The Binding Pocket of G-Protein-Coupled Receptors for Biogenic Amines, Retinal, and Other Ligands

Lei Shi, J. Javitch, 2003 .

Tianeptine promotes lasting antiallodynic effects in a mouse model of neuropathic pain

J. Javitch, Li Shen, V. Zachariou, 2023, Neuropsychopharmacology.

Disrupting D2-NMDA receptor heteromerization blocks the rewarding effects of cocaine but preserves natural reward processing

J. Caboche, J. Javitch, A. Bemelmans, 2021, bioRxiv.

Parkinsonism-inducing neurotoxin, N-methyl-4-phenyl-1,2,3,6 -tetrahydropyridine: uptake of the metabolite N-methyl-4-phenylpyridine by dopamine neurons explains selective toxicity.

S. Snyder, R. D'Amato, S. Strittmatter, 1985, Proceedings of the National Academy of Sciences of the United States of America.

Uptake of MPP(+) by dopamine neurons explains selectivity of parkinsonism-inducing neurotoxin, MPTP.

S. Snyder, J. Javitch, J. Javitch, 1984, European journal of pharmacology.

Role of transmembrane helix 6 in substrate recognition of the amino acid transporter MhsT

J. Javitch, J. Lyons, P. Nissen, 2020, bioRxiv.

The role of transmembrane segment 5 (TM5) in Na2 release and the conformational transition of neurotransmitter:sodium symporters toward the inward-open state

H. Weinstein, Lei Shi, J. Javitch, 2017, The Journal of Biological Chemistry.

Mechanism of the Association between Na+ Binding and Conformations at the Intracellular Gate in Neurotransmitter:Sodium Symporters*

George Khelashvili, Jonathan A. Javitch, Harel Weinstein, 2015, The Journal of Biological Chemistry.

Substrate-dependent proton antiport in neurotransmitter:sodium symporters

H. Weinstein, Lei Shi, J. Javitch, 2009, Nature chemical biology.

Substrate-modulated Gating Dynamics in a Na + -coupled Neurotransmitter Transporter Homolog Nih Public Access

J. Javitch, S. Blanchard, Harel Weinstein, 2022 .

Probing conformational changes in neurotransmitter transporters: a structural context.

Orkun S. Soyer, Harel Weinstein, Thijs Beuming, 2003, European journal of pharmacology.

Recognition sites for norepinephrine uptake: regulation by neurotransmitter.

J. Javitch, S. Snyder, C. Lee, 1983, Science.

[3H]mazindol binding associated with neuronal dopamine and norepinephrine uptake sites.

S. Snyder, J. Javitch, R. Blaustein, 1984, Molecular pharmacology.

Autoradiographic visualization of angiotensin-converting enzyme in rat brain with [3H]captopril: localization to a striatonigral pathway.

S. Snyder, S. Strittmatter, J. Javitch, 1984, Proceedings of the National Academy of Sciences of the United States of America.

High Affinity Dopamine D3 Receptor (D3R)-Selective Antagonists Attenuate Heroin Self-Administration in Wild-Type but not D3R Knockout Mice

Z. Xi, J. Javitch, A. Newman, 2015, Journal of medicinal chemistry.

Dopaminergic D2 receptor modulation of striatal cholinergic interneurons contributes to sequence learning

D. Lovinger, J. Javitch, C. Kellendonk, 2023, bioRxiv.

Dopamine Transporter Activity Mediates Amphetamine-Induced Inhibition of Akt through a Ca2+/Calmodulin-Dependent Kinase II-Dependent Mechanism

J. Javitch, A. Galli, C. Saunders, 2007, Molecular Pharmacology.

TRAC: A Platform for Structure-Function Studies of NSS-Proteins Integrates Information from Bioinformatics and Biomedical Literature

Jonathan A. Javitch, Marko Srdanovic, Lucy Skrabanek, 2010, 2010 IEEE International Conference on BioInformatics and BioEngineering.

The structural determinants of the bitopic binding mode of a negative allosteric modulator of the dopamine D2 receptor

A. Christopoulos, Lei Shi, J. Javitch, 2018, Biochemical pharmacology.

Detecting GPCR Complexes in Postmortem Human Brain with Proximity Ligation Assay and A Bayesian Classifier

A. Dwork, J. Javitch, Ziyi Sun, 2019, bioRxiv.

Cholinergic agonists as novel treatments for schizophrenia: the promise of rational drug development for psychiatry.

J. Lieberman, H. Moore, J. Javitch, 2008, The American journal of psychiatry.

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

J. Javitch, M. Filizola, A. Váradi, 2016, Journal of the American Chemical Society.

In‐Cell Arrestin‐Receptor Interaction Assays

J. Javitch, N. Lambert, V. Gurevich, 2023, Current protocols.

Evidence for limited D1 and D2 receptor coexpression and colocalization within the dorsal striatum of the neonatal mouse

J. Javitch, C. Kellendonk, P. Trifilieff, 2015, The Journal of comparative neurology.

Roles of the Akt/GSK-3 and Wnt signaling pathways in schizophrenia and antipsychotic drug action.

J. Javitch, S. Ferrando, Z. Freyberg, 2010, The American journal of psychiatry.

A Novel "Activation Switch" Motif Common to All Aminergic Receptors

J. Javitch, Lei Shi, Kuo-Hao Lee, 2023, J. Chem. Inf. Model..

A Novel Mitragynine Analog with Low-Efficacy Mu Opioid Receptor Agonism Displays Antinociception with Attenuated Adverse Effects.

Elyssa B. Margolis, B. Roth, J. Javitch, 2021, Journal of medicinal chemistry.

Flotillin-1 is essential for PKC-triggered endocytosis and membrane microdomain localization of DAT

J. Javitch, R. Vaughan, Nicole K. Speed, 2011, Nature Neuroscience.

Substrate-modulated gating dynamics in a Na+-coupled neurotransmitter transporter homolog

Daniel S. Terry, H. Weinstein, Lei Shi, 2011, Nature.

Electronic tuning of self-healing fluorophores for live-cell and single-molecule imaging

J. Javitch, Hong Zhao, Zhou Zhou, 2016, Chemical Science.