D. V. van Aalten

发表

PRODRG: a tool for high-throughput crystallography of protein-ligand complexes.

A. W. Schüttelkopf, D. V. van Aalten, 2004, Acta crystallographica. Section D, Biological crystallography.

Domain motions in bacteriophage T4 lysozyme: A comparison between molecular dynamics and crystallographic data

H. Berendsen, B. L. de Groot, S. Hayward, 1998, Proteins.

An efficient method for sampling the essential subspace of proteins.

H J Berendsen, H. Berendsen, B. L. de Groot, 1996, Journal of biomolecular structure & dynamics.

A comparison of techniques for calculating protein essential dynamics

H. Berendsen, B. L. de Groot, D. V. van Aalten, 1997 .

Prediction of protein conformational freedom from distance constraints

G. Vriend, H. Berendsen, B. L. de Groot, 1997, Proteins.

Interactions of LY333531 and other bisindolyl maleimide inhibitors with PDK1.

A. W. Schüttelkopf, D. V. van Aalten, D. Alessi, 2004, Structure.

The consistency of large concerted motions in proteins in molecular dynamics simulations.

H. Berendsen, B. L. de Groot, D. V. van Aalten, 1996, Biophysical journal.

High resolution crystal structure of the human PDK1 catalytic domain defines the regulatory phosphopeptide docking site

David Komander, Ricardo M Biondi, Maria Deak, 2002, The EMBO journal.

Structure of a two-domain chitotriosidase from Serratia marcescens at 1.9-A resolution.

B. Synstad, D. V. van Aalten, R. Wierenga, 2000, Proceedings of the National Academy of Sciences of the United States of America.

Structure-Based Dissection of the Natural Product Cyclopentapeptide Chitinase Inhibitor Argifin

Ian M. Eggleston, D. V. van Aalten, Amit Nathubhai, 2008, Chemistry & biology.

Inhibitors against Fungal Cell Wall Remodeling Enzymes

D. V. van Aalten, I. Navratilova, P. Merino, 2018, ChemMedChem.

Targeting a critical step in fungal hexosamine biosynthesis

D. V. van Aalten, D. Robinson, O. Raimi, 2020, The Journal of Biological Chemistry.

Structural basis for UCN-01 (7-hydroxystaurosporine) specificity and PDK1 (3-phosphoinositide-dependent protein kinase-1) inhibition.

David Komander, Dario R Alessi, D. V. van Aalten, 2003, The Biochemical journal.

Dynamic properties of the guanine nucleotide binding protein alpha subunit and comparison of its guanosine triphosphate hydrolase domain with that of ras p21.

D. V. van Aalten, L. Mello, J. Findlay, 1998, Biochemistry.

Crystal structure of the liganded SCP-2-like domain of human peroxisomal multifunctional enzyme type 2 at 1.75 A resolution.

J. Hiltunen, D. V. van Aalten, R. Wierenga, 2001, Journal of molecular biology.

Genetic validation of Aspergillus fumigatus phosphoglucomutase as a viable therapeutic target in invasive aspergillosis

D. V. van Aalten, O. Raimi, W. Fang, 2022, The Journal of biological chemistry.

Engineering Photocycle Dynamics

K. Hellingwerf, L. Joshua-Tor, D. V. van Aalten, 2002, The Journal of Biological Chemistry.

Sequence, chromophore extraction and 3-D model of the photoactive yellow protein from Rhodobacter sphaeroides.

K. Hellingwerf, S. M. Hoffer, D. V. van Aalten, 1998, Biochimica et biophysica acta.

The Non-catalytic Chitin-binding Protein CBP21 from Serratia marcescens Is Essential for Chitin Degradation*♦

B. Synstad, D. V. van Aalten, V. Eijsink, 2005, Journal of Biological Chemistry.

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

D. V. van Aalten, M. Gundogdu, S. Joss, 2019, Proceedings of the National Academy of Sciences.

O-GlcNAc transferase inhibitors: current tools and future challenges.

D. V. van Aalten, K. Rafie, Riccardo Trapannone, 2016, Biochemical Society transactions.

Direct Monitoring of Protein O-GlcNAcylation by High-Resolution Native Mass Spectrometry

A. Heck, D. V. van Aalten, Aneika C. Leney, 2017, ACS chemical biology.

O-GlcNAcase contributes to cognitive function in Drosophila

D. V. van Aalten, A. Schenck, Michaela Fenckova, 2020, The Journal of Biological Chemistry.

Chemical Dissection of the Link between Streptozotocin, O-glcnac, and Pancreatic Cell Death

D. V. van Aalten, V. Borodkin, Shalini Pathak, 2022 .

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Bin Wang, D. V. van Aalten, A. Sanz, 2019, Nature Communications.

A mutant O-GlcNAcase enriches Drosophila developmental regulators.

D. V. van Aalten, D. Campbell, R. Gourlay, 2017, Nature chemical biology.

The Vibrio cholerae Colonization Factor GbpA Possesses a Modular Structure that Governs Binding to Different Host Surfaces

D. V. van Aalten, D. Svergun, P. Konarev, 2012, PLoS pathogens.

Molecular recognition: O-GlcNAc transfer: size matters.

D. V. van Aalten, L. M. Gay, Xiaowei Zheng, 2011, Nature chemical biology.

Protein O-GlcNAcylation Is Required for Fibroblast Growth Factor Signaling in Drosophila

M. Ferguson, D. V. van Aalten, K. Mariño, 2011, Science Signaling.

Binding to serine 65-phosphorylated ubiquitin primes Parkin for optimal PINK1-dependent phosphorylation and activation

A. Prescott, D. V. van Aalten, D. Alessi, 2015, EMBO reports.

Discovery of catalytically active orthologues of the Parkinson's disease kinase PINK1: analysis of substrate specificity and impact of mutations

A. Whitworth, L. Cantley, D. V. van Aalten, 2011, Open Biology.

Molecular mechanisms of O-GlcNAcylation.

D. V. van Aalten, R. Hurtado-Guerrero, H. Dorfmueller, 2008, Current opinion in structural biology.

Intellectual disability-associated disruption of O-GlcNAc cycling impairs habituation learning in Drosophila

D. V. van Aalten, A. Schenck, Michaela Fenckova, 2022, PLoS genetics.

Mutational and computational analysis of the role of conserved residues in the active site of a family 18 chitinase.

S. Gåseidnes, B. Synstad, G. Vriend, 2004, European journal of biochemistry.

UDP-GlcNAc Analogues as Inhibitors of O-GlcNAc Transferase (OGT): Spectroscopic, Computational, and Biological Studies.

D. V. van Aalten, P. Merino, D. Perrone, 2018, Chemistry.

Solid-phase synthesis of cyclic peptide chitinase inhibitors: SAR of the argifin scaffold

D. V. van Aalten, Amit Nathubhai, I. Eggleston, 2008, Organic & biomolecular chemistry.

An efficient synthesis of argifin: a natural product chitinase inhibitor with chemotherapeutic potential.

D. V. van Aalten, I. Eggleston, Mark J. Dixon, 2005, Bioorganic & medicinal chemistry letters.

Glucose and glutamine fuel protein O-GlcNAcylation to control T cell self-renewal and malignancy

Linda V. Sinclair, D. V. van Aalten, K. Grzes, 2016, Nature Immunology.

Acta Crystallographica Section D Biological

D. V. van Aalten, D. Komander, N. Morrice, 2003 .

Bioinformatic prediction of putative conveyers of O-GlcNAc transferase intellectual disability

D. V. van Aalten, Ignacy Czajewski, Conor W. Mitchell, 2022, The Journal of biological chemistry.

The Early Metazoan Trichoplax adhaerens Possesses a Functional O-GlcNAc System

Henk W. P. van den Toorn, A. Heck, D. V. van Aalten, 2015, The Journal of Biological Chemistry.

The conserved threonine-rich region of the HCF-1PRO repeat activates promiscuous OGT:UDP-GlcNAc glycosylation and proteolysis activities

W. Herr, D. V. van Aalten, V. Zoete, 2018, The Journal of Biological Chemistry.

Highly specific inhibition of leukaemia virus membrane fusion by interaction of peptide antagonists with a conserved region of the coiled coil of envelope

A. W. Schüttelkopf, D. V. van Aalten, D. W. Brighty, 2008, Retrovirology.

Phosphoglucose Isomerase Is Important for Aspergillus fumigatus Cell Wall Biogenesis

D. V. van Aalten, Cheng Jin, O. Raimi, 2022, mBio.

Proteolysis of HCF-1 by Ser/Thr glycosylation-incompetent O-GlcNAc transferase:UDP-GlcNAc complexes

W. Herr, D. V. van Aalten, V. Zoete, 2016, Genes & development.

O-GlcNAcase: Promiscuous Hexosaminidase or Key Regulator of O-GlcNAc Signaling?

D. V. van Aalten, J. Alonso, M. Schimpl, 2014, The Journal of Biological Chemistry.

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

D. V. van Aalten, I. Eggleston, A. Recklies, 2012, The Biochemical journal.

GacA is essential for Group A S treptococcus and defines a new class of monomeric dTDP‐4‐dehydrorhamnose reductases (RmlD)

Samantha L. van der Beek, D. V. van Aalten, Y. Le Breton, 2015, Molecular microbiology.

O-GlcNAcylation enhances CPS1 catalytic efficiency for ammonia and promotes ureagenesis

N. Brunetti‐Pierri, D. V. van Aalten, E. Richard, 2022, Nature Communications.

An efficient and versatile synthesis of GlcNAcstatins—potent and selective O-GlcNAcase inhibitors built on the tetrahydroimidazo[1,2-a]pyridine scaffold

D. V. van Aalten, V. Borodkin, 2010, Tetrahedron.

A mutant bacterial O-GlcNAcase visualizes a progressive decline of protein O-GlcNAcylation in early Drosophila embryos critical for neurodevelopment

D. V. van Aalten, Zhuohua Zhang, Hai-Na Yu, 2022, bioRxiv.

A sweet TET‐à‐tête‐synergy of TET proteins and O‐GlcNAc transferase in transcription

D. V. van Aalten, Shalini Pathak, D. Mariappa, 2013, The EMBO journal.

Evolution of the Aldose Reductase-Related Gecko Eye Lens Protein ρB-Crystallin: A Sheep in Wolf's Clothing

D. V. van Aalten, W. D. de Jong, M. V. van Boekel, 2001, Journal of Molecular Evolution.

Natural product family 18 chitinase inhibitors.

D. V. van Aalten, I. Eggleston, Mark J. Dixon, 2005, Natural product reports.

Crystal structure of carboxypeptidase A complexed with D-cysteine at 1.75 A - inhibitor-induced conformational changes.

L. Joshua-Tor, C. Chong, D. V. van Aalten, 2000, Biochemistry.

Essential dynamics of lipase binding sites: the effect of inhibitors of different chain length.

D. V. van Aalten, R. Bywater, G. Peters, 1997, Protein engineering.

Acetazolamide-based fungal chitinase inhibitors

Ian H. Gilbert, I. Gilbert, A. W. Schüttelkopf, 2010, Bioorganic & medicinal chemistry.

Structure-based exploration of cyclic dipeptide chitinase inhibitors.

B. Synstad, D. V. van Aalten, V. Eijsink, 2004, Journal of medicinal chemistry.

Structural insights into mechanism and specificity of O-GlcNAc transferase

A. W. Schüttelkopf, D. V. van Aalten, V. Borodkin, 2008, The EMBO journal.

Substrate and product analogues as human O-GlcNAc transferase inhibitors

D. V. van Aalten, I. Navratilova, V. Borodkin, 2010, Amino Acids.

Bisdionin C-a rationally designed, submicromolar inhibitor of family 18 chitinases.

A. W. Schüttelkopf, D. V. van Aalten, Francesco V Rao, 2011, ACS medicinal chemistry letters.

Screening-based Discovery and Structural Dissection of a Novel Family 18 Chitinase Inhibitor*

Clare Lloyd, A. W. Schüttelkopf, D. V. van Aalten, 2006, Journal of Biological Chemistry.

Methylxanthine drugs are chitinase inhibitors: investigation of inhibition and binding modes.

D. V. van Aalten, K. Vora, J. Demartino, 2005, Chemistry & biology.

Specificity and affinity of natural product cyclopentapeptide inhibitors against A. fumigatus, human, and bacterial chitinases.

S. Ōmura, D. V. van Aalten, David John Adams, 2004, Chemistry & biology.

Crystal Structures of Allosamidin Derivatives in Complex with Human Macrophage Chitinase*

D. V. van Aalten, S. Sakuda, R. Boot, 2003, Journal of Biological Chemistry.

The cyclic dipeptide CI-4 [cyclo-(l-Arg-d-Pro)] inhibits family 18 chitinases by structural mimicry of a reaction intermediate.

B. Synstad, D. V. van Aalten, V. Eijsink, 2002, The Biochemical journal.

Structure of Human Chitotriosidase

D. V. van Aalten, B. Dijkstra, H. Rozeboom, 2002, The Journal of Biological Chemistry.

High-resolution structures of a chitinase complexed with natural product cyclopentapeptide inhibitors: Mimicry of carbohydrate substrate

S. Ōmura, B. Synstad, D. V. van Aalten, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax.

B. Synstad, D. V. van Aalten, D. Komander, 2002, Bioorganic & medicinal chemistry.

The structure of siglec-7 in complex with sialosides: leads for rational structure-based inhibitor design.

D. V. van Aalten, T. Ando, H. Attrill, 2006, The Biochemical journal.

Structure of the OSR1 kinase, a hypertension drug target

D. V. van Aalten, D. Alessi, M. Deák, 2008, Proteins.

Structure of the LKB1-STRAD-MO25 Complex Reveals an Allosteric Mechanism of Kinase Activation

Maria Deak, Dario R Alessi, D. V. van Aalten, 2009, Science.

The N-Acetyl-D-glucosaminylphosphatidylinositol De-N-acetylase of Glycosylphosphatidylinositol Biosynthesis Is a Zinc Metalloenzyme*

Terry K. Smith, Terry K Smith, Michael D. Urbaniak, 2005, Journal of Biological Chemistry.

The citron homology domain as a scaffold for Rho1 signaling

D. V. van Aalten, Wenfan Wei, S. G. Bartual, 2021, Proceedings of the National Academy of Sciences.

Genetic and structural validation of phosphomannomutase as a cell wall target in Aspergillus fumigatus

D. V. van Aalten, Ling Lu, O. Raimi, 2021, Molecular microbiology.

Structure and mechanism of chitin deacetylase from the fungal pathogen Colletotrichum lindemuthianum.

S. Withers, A. W. Schüttelkopf, D. V. van Aalten, 2006, Biochemistry.

Charge-Surrounded Pockets and Electrostatic Interactions with Small Ions Modulate the Activity of Retroviral Fusion Proteins

A. W. Schüttelkopf, D. V. van Aalten, D. W. Brighty, 2011, PLoS pathogens.

Structural and functional characterization of a putative polysaccharide deacetylase of the human parasite Encephalitozoon cuniculi

D. V. van Aalten, V. Eijsink, C. Texier, 2009, Protein science : a publication of the Protein Society.

Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4

D. V. van Aalten, G. Mathiesen, V. Eijsink, 2017, Scientific Reports.

Structures of Bacillus subtilis PdaA, a family 4 carbohydrate esterase, and a complex with N‐acetyl‐glucosamine

D. V. van Aalten, D. Blair, 2004, FEBS letters.

Gecko iota-crystallin: how cellular retinol-binding protein became an eye lens ultraviolet filter.

D. V. van Aalten, W. D. de Jong, P. Werten, 2000, Proceedings of the National Academy of Sciences of the United States of America.

High resolution crystal structures of unliganded and liganded human liver ACBP reveal a new mode of binding for the acyl‐CoA ligand

D. V. van Aalten, R. Wierenga, J. Knudsen, 2006, Proteins.

Binding site differences revealed by crystal structures of Plasmodium falciparum and bovine acyl-CoA binding protein.

G J Kleywegt, T A Jones, G. Kleywegt, 2001, Journal of molecular biology.

GlcNAcstatin: a picomolar, selective O-GlcNAcase inhibitor that modulates intracellular O-glcNAcylation levels.

D. V. van Aalten, N. Shpiro, V. Borodkin, 2006, Journal of the American Chemical Society.

Structural insights into the mechanism and inhibition of eukaryotic O‐GlcNAc hydrolysis

D. V. van Aalten, F. Villa, I. Eggleston, 2006, The EMBO journal.

Screening-based discovery of drug-like O-GlcNAcase inhibitor scaffolds

D. V. van Aalten, Helge C. Dorfmueller, Daan M.F. van Aalten, 2010, FEBS letters.

GlcNAcstatins are nanomolar inhibitors of human O-GlcNAcase inducing cellular hyper-O-GlcNAcylation

D. V. van Aalten, V. Borodkin, M. Schimpl, 2009, The Biochemical journal.

The transfer of transthyretin and receptor-binding properties from the plasma retinol-binding protein to the epididymal retinoic acid-binding protein.

D. V. van Aalten, J. Findlay, A. Sivaprasadarao, 2002, The Biochemical journal.

N-Myristoyltransferase inhibitors as new leads to treat sleeping sickness

Ian H. Gilbert, Chidochangu P. Mpamhanga, Michael Hodgkinson, 2010, Nature.

Natural product-guided discovery of a fungal chitinase inhibitor.

A. W. Schüttelkopf, D. V. van Aalten, I. Eggleston, 2010, Chemistry & biology.

Streptococcus mutans SMU.623c Codes for a Functional, Metal-Dependent Polysaccharide Deacetylase That Modulates Interactions with Salivary Agglutinin

D. V. van Aalten, W. Crielaard, D. Deng, 2008, Journal of bacteriology.

Structural and kinetic differences between human and Aspergillus fumigatus D-glucosamine-6-phosphate N-acetyltransferase.

J. Min, D. V. van Aalten, A. Plotnikov, 2008, The Biochemical journal.

Glucose‐6‐phosphate as a probe for the glucosamine‐6‐phosphate N‐acetyltransferase Michaelis complex

D. V. van Aalten, O. Raimi, S. Shepherd, 2007, FEBS letters.

Structure and metal-dependent mechanism of peptidoglycan deacetylase, a streptococcal virulence factor

A. W. Schüttelkopf, D. V. van Aalten, J. MacRae, 2005, Proceedings of the National Academy of Sciences of the United States of America.

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

A. Prescott, D. V. van Aalten, D. Alessi, 2004, The EMBO journal.

PDK1, the master regulator of AGC kinase signal transduction.

D. V. van Aalten, D. Alessi, D. Komander, 2004, Seminars in cell & developmental biology.

Catalytic deficiency of O-GlcNAc transferase leads to X-linked intellectual disability

D. V. van Aalten, M. Gundogdu, S. Joss, 2019, Proceedings of the National Academy of Sciences.

Elevated O‐GlcNAc Levels Activate Epigenetically Repressed Genes and Delay Mouse ESC Differentiation Without Affecting Naïve to Primed Cell Transition

G. Barton, D. V. van Aalten, M. Mudaliar, 2014, Stem cells.

Conformational substates in different crystal forms of the photoactive yellow protein—Correlation with theoretical and experimental flexibility

K. Hellingwerf, L. Joshua-Tor, D. V. van Aalten, 2008, Protein science : a publication of the Protein Society.

Tyrosine glycosylation of Rho by Yersinia toxin impairs blastomere cell behaviour in zebrafish embryos

W. Driever, D. V. van Aalten, S. Wiese, 2015, Nature Communications.

Engineering protein mechanics: inhibition of concerted motions of the cellular retinol binding protein by site-directed mutagenesis.

D. V. van Aalten, J. Findlay, P. Jones, 1997, Protein engineering.

Intellectual disability-associated disruption of O-GlcNAcylation impairs neuronal development and cognitive function in Drosophila

D. V. van Aalten, A. Schenck, Michaela Fenckova, 2022, bioRxiv.

Crystal structure of the phosphatidylinositol 3,4-bisphosphate-binding pleckstrin homology (PH) domain of tandem PH-domain-containing protein 1 (TAPP1): molecular basis of lipid specificity.

S. Dowler, D. V. van Aalten, D. Alessi, 2001, The Biochemical journal.

Proteome Wide Purification and Identification of O‑glcnac-modified Proteins Using Click Chemistry and Mass Spectrometry

B. Kuster, Hannes Hahne, D. Helm, 2022 .

Mutations in N-acetylglucosamine (O-GlcNAc) transferase in patients with X-linked intellectual disability

R. Pfundt, D. V. van Aalten, M. Kempers, 2017, The Journal of Biological Chemistry.

Protein dynamics derived from clusters of crystal structures.

J B Findlay, H J Berendsen, H. Berendsen, 1997, Biophysical journal.

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

D. V. van Aalten, D. Alessi, J. Boudeau, 2009, PLoS biology.

TAK1-binding protein 1 is a pseudophosphatase.

P. Cohen, A. W. Schüttelkopf, D. V. van Aalten, 2006, The Biochemical journal.

The active site of O-GlcNAc transferase imposes constraints on substrate sequence

A. W. Schüttelkopf, D. V. van Aalten, J. Alonso, 2015, Nature Structural &Molecular Biology.

Structure of PINK1 and mechanisms of Parkinson's disease-associated mutations

D. V. van Aalten, M. Peggie, M. Muqit, 2017, eLife.

Pseudokinases-remnants of evolution or key allosteric regulators?

D. V. van Aalten, E. Zeqiraj, Elton Zeqiraj, 2010, Current opinion in structural biology.

Analysis of the LKB1-STRAD-MO25 complex

A. Prescott, D. V. van Aalten, D. Hardie, 2004, Journal of Cell Science.

Role of T-loop Phosphorylation in PDK1 Activation, Stability, and Substrate Binding*

Dario R. Alessi, David Komander, Maria Deak, 2005, Journal of Biological Chemistry.

Molecular mechanism of elongation factor 1A inhibition by a Legionella pneumophila glycosyltransferase.

A. Prescott, D. V. van Aalten, T. Zusman, 2010, The Biochemical journal.

THE CRYSTAL STRUCTURE

J. Hiltunen, D. V. van Aalten, R. Wierenga, 2010 .

Loss of O-GlcNAcase catalytic activity leads to defects in mouse embryogenesis

D. V. van Aalten, L. Teboul, J. Gallagher, 2021, The Journal of biological chemistry.

A missense mutation in a patient with developmental delay affects the activity and structure of the hexosamine biosynthetic pathway enzyme AGX1

D. V. van Aalten, O. Raimi, A. Ferenbach, 2020, FEBS letters.

Tools for functional dissection of site-specific O-GlcNAcylation

D. V. van Aalten, A. Gorelik, 2020, RSC chemical biology.

An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase

J. Gécz, C. Schwartz, D. V. van Aalten, 2020, European Journal of Human Genetics.

Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice

K. Read, A. Heck, D. V. van Aalten, 2019, Open Biology.

Thio-Linked UDP–Peptide Conjugates as O-GlcNAc Transferase Inhibitors

D. V. van Aalten, V. Borodkin, K. Rafie, 2018, Bioconjugate chemistry.

Structure of a bacterial putative acetyltransferase defines the fold of the human O-GlcNAcase C-terminal domain

A. W. Schüttelkopf, D. V. van Aalten, I. Navratilova, 2013, Open Biology.

Lead Optimization of a Pyrazole Sulfonamide Series of Trypanosoma bruceiN-Myristoyltransferase Inhibitors: Identification and Evaluation of CNS Penetrant Compounds as Potential Treatments for Stage 2 Human African Trypanosomiasis

Stuart P. McElroy, S. Norval, Frederick R. C. Simeons, 2014, Journal of medicinal chemistry.

Mutation of the PDK1 PH Domain Inhibits Protein Kinase B/Akt, Leading to Small Size and Insulin Resistance

D. V. van Aalten, F. Lang, D. Alessi, 2008, Molecular and Cellular Biology.

Crystal Structure and Binding Properties of the Serratia marcescens Chitin-binding Protein CBP21*

D. V. van Aalten, V. Eijsink, G. Vaaje-Kolstad, 2005, Journal of Biological Chemistry.

Genetic recoding to dissect the roles of site-specific protein O-GlcNAcylation

D. V. van Aalten, S. G. Bartual, V. Borodkin, 2019, Nature Structural & Molecular Biology.

Structure and Ligand-induced Conformational Change of the 39-kDa Glycoprotein from Human Articular Chondrocytes*

D. V. van Aalten, J. Krupa, Daan M F van Aalten, 2003, Journal of Biological Chemistry.

Structural insights into the catalytic mechanism of a family 18 exo-chitinase

S. Gåseidnes, B. Synstad, D. V. van Aalten, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Kinetic, inhibition and structural studies on 3-oxoacyl-ACP reductase from Plasmodium falciparum, a key enzyme in fatty acid biosynthesis.

A. Fairlamb, S. Müller, D. V. van Aalten, 2006, The Biochemical journal.

Structure and function of a broad-specificity chitin deacetylase from Aspergillus nidulans FGSC A4

D. V. van Aalten, G. Mathiesen, V. Eijsink, 2017, Scientific Reports.

Evidence for a Functional O-Linked N-Acetylglucosamine (O-GlcNAc) System in the Thermophilic Bacterium Thermobaculum terrenum

D. V. van Aalten, A. Lebedev, M. Gundogdu, 2015, The Journal of Biological Chemistry.

Structural Basis of Reduction-dependent Activation of Human Cystatin F*

A. W. Schüttelkopf, D. V. van Aalten, C. Watts, 2006, Journal of Biological Chemistry.

The ubiquitin-associated domain of AMPK-related kinases regulates conformation and LKB1-mediated phosphorylation and activation.

A. Prescott, D. V. van Aalten, D. Alessi, 2006, The Biochemical journal.

Yeast Mnn9 is both a priming glycosyltransferase and an allosteric activator of mannan biosynthesis

A. W. Schüttelkopf, D. V. van Aalten, D. Robinson, 2013, Open Biology.

N-Myristoyltransferase Is a Cell Wall Target in Aspergillus fumigatus

G. F. Ruda, I. Gilbert, D. V. van Aalten, 2015, ACS chemical biology.

The role of O-GlcNAcylation in development.

D. V. van Aalten, Ignacy Czajewski, 2023, Development.

Crystal structure of FadR, a fatty acid‐responsive transcription factor with a novel acyl coenzyme A‐binding fold

D. V. van Aalten, R. Wierenga, J. Knudsen, 2000, The EMBO journal.

The essential dynamics of thermolysin: Confirmation of the hinge‐bending motion and comparison of simulations in vacuum and water

G Vriend, H J Berendsen, G. Vriend, 1995, Proteins.

A Novel Allosteric Inhibitor of the Uridine Diphosphate N-Acetylglucosamine Pyrophosphorylase from Trypanosoma brucei

Michael D. Urbaniak, M. Ferguson, D. V. van Aalten, 2013, ACS chemical biology.

Chemical tools to probe cellular O-GlcNAc signalling.

D. V. van Aalten, A. Ostrowski, 2013, The Biochemical journal.

Dual functionality of O-GlcNAc transferase is required for Drosophila development

D. V. van Aalten, H. Müller, O. Raimi, 2015, Open Biology.

O-GlcNAc transferase invokes nucleotide sugar pyrophosphate participation in catalysis

A. W. Schüttelkopf, D. V. van Aalten, D. Robinson, 2012, Nature chemical biology.

BslA is a self-assembling bacterial hydrophobin that coats the Bacillus subtilis biofilm

C. MacPhee, A. Prescott, D. V. van Aalten, 2013, Proceedings of the National Academy of Sciences.

IQGAP Proteins Reveal an Atypical Phosphoinositide (aPI) Binding Domain with a Pseudo C2 Domain Fold*

D. V. van Aalten, I. Batty, C. Downes, 2012, The Journal of Biological Chemistry.

A structural snapshot of base-pair opening in DNA.

L. Joshua-Tor, D. V. van Aalten, G. Verdine, 1999, Proceedings of the National Academy of Sciences of the United States of America.

Siglec-7 Undergoes a Major Conformational Change When Complexed with the α(2,8)-Disialylganglioside GT1b*

D. V. van Aalten, H. Attrill, M. Kiso, 2006, Journal of Biological Chemistry.

A mouse model for functional dissection of TAB1 O-GlcNAcylation.

D. V. van Aalten, Villő Muha, Florence Authier, 2019, Wellcome open research.

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

D. V. van Aalten, D. Campbell, V. Borodkin, 2010, The EMBO journal.

Novel inositol phospholipid headgroup surrogate crystallized in the pleckstrin homology domain of protein kinase Balpha.

D. V. van Aalten, D. Komander, B. Potter, 2007, ACS chemical biology.

A Trapped Covalent Intermediate of a Glycoside Hydrolase on the Pathway to Transglycosylation. Insights from Experiments and Quantum Mechanics/Molecular Mechanics Simulations.

D. V. van Aalten, C. Rovira, J. Castro-López, 2016, Journal of the American Chemical Society.

A mechanism-inspired UDP-N-acetylglucosamine pyrophosphorylase inhibitor

Michael D. Urbaniak, M. Ferguson, D. V. van Aalten, 2020, RSC chemical biology.

Screening-based discovery of Aspergillus fumigatus plant-type chitinase inhibitors

D. V. van Aalten, D. Lockhart, A. Schuettelkopf, 2014, FEBS letters.

Analyzing Airway Inflammation with Chemical Biology: Dissection of Acidic Mammalian Chitinase Function with a Selective Drug-like Inhibitor

R. Maizels, D. V. van Aalten, T. Sutherland, 2011, Chemistry & biology.

Structure of Saccharomyces cerevisiae chitinase 1 and screening-based discovery of potent inhibitors.

D. V. van Aalten, R. Hurtado‐Guerrero, 2007, Chemistry & biology.

Essential dynamics from NMR clusters: dynamic properties of the Myb DNA-binding domain and a hinge-bending enhancing variant.

L. Joshua-Tor, E. Grotewold, D. V. van Aalten, 1998, Methods.

Dynamics of proteins in different solvent systems: analysis of essential motion in lipases.

D. V. van Aalten, O. Edholm, R. Bywater, 1996, Biophysical journal.

A comparison of structural and dynamic properties of different simulation methods applied to SH3.

C. Sander, H. Berendsen, D. V. van Aalten, 1996, Biophysical journal.

Pound-wise but penny-foolish: How well do micromolecules fare in macromolecular refinement?

Gerard J Kleywegt, G. Kleywegt, K. Henrick, 2003, Structure.

Crystal Structure of the PTPL1/FAP-1 Human Tyrosine Phosphatase Mutated in Colorectal Cancer

Maria Deak, Dario R Alessi, D. V. van Aalten, 2004, Journal of Biological Chemistry.

Comparison of ras-p21 bound to GDP and GTP: differences in protein and ligand dynamics.

D. V. van Aalten, L. Mello, J. Findlay, 1997, Protein Engineering.

An O-GlcNAc transferase pathogenic variant that affects pluripotent stem cell self-renewal

D. V. van Aalten, A. Bayat, M. Stavridis, 2023, bioRxiv.

Effects of hypo-O-GlcNAcylation on Drosophila development

D. V. van Aalten, A. Ferenbach, D. Mariappa, 2018, The Journal of Biological Chemistry.

Synergy of Peptide and Sugar in O-GlcNAcase Substrate Recognition

D. V. van Aalten, V. Borodkin, M. Schimpl, 2012, Chemistry & biology.

Human OGA binds substrates in a conserved peptide recognition groove

A. W. Schüttelkopf, D. V. van Aalten, V. Borodkin, 2010, The Biochemical journal.

Recognition of a glycosylation substrate by the O-GlcNAc transferase TPR repeats

D. V. van Aalten, V. Borodkin, O. Raimi, 2017, Open Biology.

Structure of the D142N mutant of the family 18 chitinase ChiB from Serratia marcescens and its complex with allosamidin.

B. Synstad, D. V. van Aalten, V. Eijsink, 2004, Biochimica et biophysica acta.

Toward an exhaustive sampling of the configurational spaces of the two forms of the peptide hormone guanylin.

H J Berendsen, H. Berendsen, B. L. de Groot, 1996, Journal of biomolecular structure & dynamics.

Essential dynamics of the cellular retinol-binding protein--evidence for ligand-induced conformational changes.

H. Berendsen, D. V. van Aalten, A. Amadei, 1995, Protein engineering.

Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.

N. C. Price, D. V. van Aalten, D. Alessi, 2003, The Biochemical journal.

Interactions of a Family 18 Chitinase with the Designed Inhibitor HM508 and Its Degradation Product, Chitobiono-δ-lactone*

B. Synstad, D. V. van Aalten, A. Vasella, 2004, Journal of Biological Chemistry.

O-GlcNAcase Fragment Discovery with Fluorescence Polarimetry.

D. V. van Aalten, I. Navratilova, V. Borodkin, 2018, ACS chemical biology.

Cell-Penetrant, Nanomolar O-GlcNAcase Inhibitors Selective against Lysosomal Hexosaminidases

K. Read, D. V. van Aalten, V. Borodkin, 2010, Chemistry & biology.

A Structural and Biochemical Model of Processive Chitin Synthesis

D. V. van Aalten, V. Borodkin, A. Ferenbach, 2014, The Journal of Biological Chemistry.

Structural insights into the recognition of substrates and activators by the OSR1 kinase

D. V. van Aalten, D. Alessi, M. Deák, 2007, EMBO reports.

Genetic and structural validation of Aspergillus fumigatus N-acetylphosphoglucosamine mutase as an antifungal target

M. Ferguson, D. V. van Aalten, Cheng Jin, 2013, Bioscience reports.

Mechanisms of redundancy and specificity of the Aspergillus fumigatus Crh transglycosylases

Bin Wang, D. V. van Aalten, A. Sanz, 2019, Nature Communications.

Phosphorylation of Synaptic Vesicle Protein 2A at Thr84 by Casein Kinase 1 Family Kinases Controls the Specific Retrieval of Synaptotagmin-1

D. V. van Aalten, D. Alessi, D. Campbell, 2015, The Journal of Neuroscience.

A mouse model for functional dissection of TAB1 O-GlcNAcylation

D. V. van Aalten, Villő Muha, Florence Authier, 2019, Wellcome open research.

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution.

K. Hellingwerf, L. Joshua-Tor, D. V. van Aalten, 2002, Acta crystallographica. Section D, Biological crystallography.

Structural and biochemical characterization of a trapped coenzyme A adduct of Caenorhabditis elegans glucosamine-6-phosphate N-acetyltransferase 1

Helen Attrill, D. V. van Aalten, H. Attrill, 2012, Acta crystallographica. Section D, Biological crystallography.

Molecular Mechanisms of Yeast Cell Wall Glucan Remodeling*

J. Latgé, A. W. Schüttelkopf, D. V. van Aalten, 2009, Journal of Biological Chemistry.

The structural basis of acyl coenzyme A‐dependent regulation of the transcription factor FadR

D. V. van Aalten, J. Knudsen, C. DiRusso, 2001, The EMBO journal.

An O-GlcNAc transferase pathogenic variant linked to intellectual disability affects pluripotent stem cell self-renewal

D. V. van Aalten, A. Bayat, M. Stavridis, 2023, Disease models & mechanisms.

Rescuable sleep and synaptogenesis phenotypes in a Drosophila model of O-GlcNAc transferase intellectual disability

D. V. van Aalten, A. Ferenbach, Laurin McDowall, 2023, bioRxiv.

Structural insights into the regulation of PDK1 by phosphoinositides and inositol phosphates

A. Prescott, D. V. van Aalten, D. Alessi, 2004 .

Purification, crystallization and preliminary X-ray diffraction of a proteolytic fragment of PDK1 containing the pleckstrin homology domain.

D. V. van Aalten, D. Komander, N. Morrice, 2004, Acta crystallographica. Section D, Biological crystallography.

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

D. V. van Aalten, D. Campbell, V. Borodkin, 2012, The EMBO Journal.

Structure of the photoactive yellow protein reconstituted with caffeic acid at 1.16 A resolution.

K. Hellingwerf, L. Joshua-Tor, D. V. van Aalten, 2002, Acta Crystallographica Section D: Biological Crystallography.

Concerted motions in the photoactive yellow protein.

K. Hellingwerf, D. V. van Aalten, J. Findlay, 1998, Protein engineering.

ATP and MO25α Regulate the Conformational State of the STRADα Pseudokinase and Activation of the LKB1 Tumour Suppressor

D. V. van Aalten, D. Alessi, J. Boudeau, 2009, PLoS Biology.

Neurodevelopmental defects in a mouse model of O-GlcNAc transferase intellectual disability

D. V. van Aalten, A. McNeilly, N. Ondrušková, 2023, bioRxiv.

An intellectual disability syndrome with single-nucleotide variants in O-GlcNAc transferase

J. Gécz, C. Schwartz, D. V. van Aalten, 2020, European Journal of Human Genetics.

Elevated O-GlcNAc levels activate epigenetically repressed genes and delay mouse ES cell differentiation without affecting naive to primed cell transition

Geoffrey, Tanja, Daan, 2014 .

Activity-based E3 ligase profiling uncovers an E3 ligase with esterification activity

D. V. van Aalten, K. Hofmann, A. Knebel, 2018, Nature.

O-GlcNAcylation of TAB1 modulates TAK1-mediated cytokine release

D. V. van Aalten, D. Campbell, V. Borodkin, 2012, The EMBO journal.

Native detection of protein O-GlcNAcylation by gel electrophoresis.

D. V. van Aalten, C. Fu, 2020, The Analyst.

Proteome wide purification and identification of O-GlcNAc-modified proteins using click chemistry and mass spectrometry.

Hannes Hahne, D. V. van Aalten, V. Borodkin, 2013, Journal of proteome research.

Human OGA binds substrates in a conserved peptide recognition groove

A. W. Schüttelkopf, D. V. van Aalten, V. Borodkin, 2010, The Biochemical journal.

Olfactory learning in Drosophila requires O-GlcNAcylation of mushroom body ribosomal subunits

D. V. van Aalten, Yaowen Zhang, Kai Yuan, 2023, bioRxiv.

Protein O-GlcNAcylation homeostasis regulates facultative heterochromatin to fine-tune sog-Dpp signaling during Drosophila early embryogenesis.

D. V. van Aalten, Zhuohua Zhang, Yaowen Zhang, 2023, Journal of genetics and genomics = Yi chuan xue bao.

Structural insights into the mechanism and inhibition of eukaryotic O‐GlcNAc hydrolysis

D. V. van Aalten, F. Villa, I. Eggleston, 2006, The EMBO journal.

A mutant O-GlcNAcase enriches Drosophila developmental regulators.

D. V. van Aalten, D. Campbell, M. Trost, 2017, Nature chemical biology.

Chemical Dissection of the Link between Streptozotocin, O-GlcNAc, and Pancreatic Cell Death

D. V. van Aalten, V. Borodkin, Shalini Pathak, 2008, Chemistry & biology.

Microsoft Word-taog_v9_all.docx

Henk W. P. van den Toorn, A. Heck, D. V. van Aalten, 2015 .

Human YKL-39 is a pseudo-chitinase with retained chitooligosaccharide-binding properties.

D. V. van Aalten, I. Eggleston, A. Recklies, 2012, The Biochemical journal.

Exploiting O-GlcNAc transferase promiscuity to dissect site-specific O-GlcNAcylation

D. V. van Aalten, S. G. Bartual, A. Ferenbach, 2023, bioRxiv.

O-GlcNAcylation of the intellectual disability protein DDX3X exerts proteostatic cell cycle control

D. V. van Aalten, A. Ferenbach, Florence Authier, 2024, bioRxiv.

Neuroectoderm phenotypes in a human stem cell model of O-GlcNAc transferase associated with intellectual disability.

D. V. van Aalten, A. Ferenbach, Marta Murray, 2024, Molecular genetics and metabolism.

Neuroectoderm phenotypes in a human stem cell model of O-GlcNAc transferase intellectual disability

D. V. van Aalten, A. Ferenbach, Marta Murray, 2023, bioRxiv.