P. Casarosa

发表

Structure of a nanobody-stabilized active state of the β2 adrenoceptor

S. Rasmussen, Brian T DeVree, T. S. Kobilka, 2010, Nature.

Kaposi's Sarcoma-Associated Herpesvirus-Encoded G Protein-Coupled Receptor ORF74 Constitutively Activates p44/p42 MAPK and Akt via Gi and Phospholipase C-Dependent Signaling Pathways

R. Leurs, P. Casarosa, M. Smit, 2002, Journal of Virology.

The human cytomegalovirus‐encoded chemokine receptor US28 induces caspase‐dependent apoptosis

R. Leurs, P. Casarosa, P. Schneider, 2005, The FEBS journal.

Receptor US 28 Cytomegalovirus-Encoded Chemokine Receptors CCR 1 and CCR 5 and the Human CCL 14 a to Activity on the Chemokine Significance of N-Terminal Proteolysis of

R. Leurs, M. Parmentier, P. Casarosa, 2009 .

In VitroCharacterization of BI 1744 CL, a Novel Long Acting ß2 Agonist: Investigations To Understand Its Long Duration of Action.

P. Casarosa, A. Schnapp, F. Gantner, 2009, ATS 2009.

Synergistic bronchoprotective activity of the long-acting beta 2-agonist olodaterol with tiotropium (long-acting M3 antagonist) and ciclesonide (inhaled steroid) on the ovalbumin-induced bronchoconstriction in anaesthetized guinea pigs

P. Casarosa, A. Schnapp, F. Gantner, 2011 .

ß2 Agonist Intrinsic Activity: Comparison Of BI 1744 And Formoterol In Different Functional Settings

P. Devillier, P. Casarosa, E. Naline, 2010, ATS 2010.

β2 long-acting and anticholinergic drugs synergistically control TGFβ1-mediated neutrophilic inflammation in COPD: An “in vitro” model

P. Casarosa, M. Profita, L. Siena, 2011 .

Addition Of The New Once-daily LABA BI 1744 To Tiotropium Results In Superior Bronchoprotection In Pre-clinical Models

P. Casarosa, A. Schnapp, T. Bouyssou, 2010, ATS 2010.

Constitutively active Gq/11-coupled Receptors Enable Signaling by Co-expressed Gi/o-coupled Receptors*

R. Leurs, P. Casarosa, M. Smit, 2004, Journal of Biological Chemistry.

Human Cytomegalovirus Chemokine Receptor US28 Induced SMC Migration is Mediated by Focal Adhesion Kinase and Src

P. Casarosa, D. Schlaepfer, M. Smit, 2003 .

Differential inverse agonism at the human muscarinic M₃ receptor.

P. Casarosa, R. Bakker, T. Kiechle, 2010, Methods in enzymology.

Smoke, Choline Acetyltransferase, Muscarinic Receptors, and Fibroblast Proliferation in Chronic Obstructive Pulmonary Disease

P. Casarosa, M. Profita, L. Siena, 2009, Journal of Pharmacology and Experimental Therapeutics.

The Constitutive Activity of the Human Muscarinic M3 Receptor Unmasks Differences in the Pharmacology of Anticholinergics

P. Casarosa, F. Gantner, P. Sieger, 2010, Journal of Pharmacology and Experimental Therapeutics.

Identification of the First Nonpeptidergic Inverse Agonist for a Constitutively Active Viral-encoded G Protein-coupled Receptor*

R. Leurs, F. Kirchhoff, P. Casarosa, 2003, The Journal of Biological Chemistry.

β₂ long-acting and anticholinergic drugs control TGF-β1-mediated neutrophilic inflammation in COPD.

P. Casarosa, M. Profita, L. Siena, 2012, Biochimica et biophysica acta.

In vitro anticholinergic drugs affect CD8+ peripheral blood T-cells apoptosis in COPD.

P. Casarosa, M. Profita, A. Bonanno, 2012, Immunobiology.

Synthesis and structure-activity relationship of the first nonpeptidergic inverse agonists for the human cytomegalovirus encoded chemokine receptor US28.

I. D. de Esch, R. Leurs, P. Casarosa, 2005, Journal of medicinal chemistry.

Virally encoded G protein-coupled receptors: targets for potentially innovative anti-viral drug development.

R. Leurs, P. Casarosa, M. Smit, 2003, Current drug targets.

The Rat Cytomegalovirus R33-Encoded G Protein-Coupled Receptor Signals in a Constitutive Fashion

R. Leurs, P. Casarosa, M. Smit, 2002, Journal of Virology.

Constitutive Fashion Protein-Coupled Receptor Signals in a The Rat Cytomegalovirus R 33-Encoded G

R. Leurs, P. Casarosa, M. Smit, 2001 .

Modulation of constitutive GPCR activity: a way of life?

R. Leurs, P. Casarosa, M. Smit, 2003 .

Understanding the Mechanism of Long Duration of Action of Tiotropium: Insight into Its Interaction with the Human M3 Receptor.

P. Casarosa, C. Tautermann, F. Gantner, 2009, ATS 2009.

Human Cytomegalovirus Chemokine Receptor US28-induced Smooth Muscle Cell Migration Is Mediated by Focal Adhesion Kinase and Src*

P. Casarosa, D. Schlaepfer, M. Smit, 2003, Journal of Biological Chemistry.

The Carboxyl Terminus of Human Cytomegalovirus-encoded 7 Transmembrane Receptor US28 Camouflages Agonism by Mediating Constitutive Endocytosis*

R. Leurs, T. Schwartz, M. Rosenkilde, 2003, Journal of Biological Chemistry.

Constitutive Signaling of the Human Cytomegalovirus-encoded Chemokine Receptor US28*

Rob Leurs, Martine J. Smit, Henk Timmerman, 2001, The Journal of Biological Chemistry.

CC and CX3C Chemokines Differentially Interact with the N Terminus of the Human Cytomegalovirus-encoded US28 Receptor*

R. Leurs, T. Schwartz, P. Casarosa, 2005, Journal of Biological Chemistry.

Muscarinic Receptor Antagonists in the Treatment of COPD

P. Casarosa, M. Pieper, M. Grauert, 2010 .

Cigarette smoke extract activates human bronchial epithelial cells affecting non-neuronal cholinergic system signalling in vitro.

P. Casarosa, M. Profita, L. Siena, 2011, Life sciences.

Significance of N-Terminal Proteolysis of CCL14a to Activity on the Chemokine Receptors CCR1 and CCR5 and the Human Cytomegalovirus-Encoded Chemokine Receptor US281

R. Leurs, M. Parmentier, P. Casarosa, 2009, The Journal of Immunology.

Constitutive Signaling of the Human Cytomegalovirus-encoded Receptor UL33 Differs from That of Its Rat Cytomegalovirus Homolog R33 by Promiscuous Activation of G Proteins of the Gq, Gi, and Gs Classes*

R. Leurs, P. Casarosa, M. Smit, 2003, Journal of Biological Chemistry.

Preclinical Evaluation of Long-Acting Muscarinic Antagonists: Comparison of Tiotropium and Investigational Drugs

P. Casarosa, A. Schnapp, F. Gantner, 2009, Journal of Pharmacology and Experimental Therapeutics.

Identifying Functional Hotspot Residues for Biased Ligand Design in G-Protein-Coupled Receptors

N. Vaidehi, P. Casarosa, C. Tautermann, 2018, Molecular Pharmacology.

Molecular basis for the long duration of action and kinetic selectivity of tiotropium for the muscarinic M3 receptor.

P. Casarosa, C. Tautermann, F. Gantner, 2013, Journal of medicinal chemistry.

Pharmacological Characterization of Olodaterol, a Novel Inhaled β2-Adrenoceptor Agonist Exerting a 24-Hour-Long Duration of Action in Preclinical Models

P. Devillier, P. Casarosa, A. Schnapp, 2010, Journal of Pharmacology and Experimental Therapeutics.

Functional and Biochemical Rationales for the 24-Hour-Long Duration of Action of Olodaterol

P. Casarosa, A. Schnapp, F. Gantner, 2011, Journal of Pharmacology and Experimental Therapeutics.