D. Liggitt

发表

Recognition of the Peripheral Self by Naturally

A. Rudensky, S. Self, C. Hsieh, 2004 .

Recognition of the peripheral self by naturally arising CD25+ CD4+ T cell receptors.

A. Rudensky, S. Self, C. Hsieh, 2004, Immunity.

Membrane-permeant, DNA-binding agents alter intracellular trafficking and increase the transfection efficiency of complexed plasmid DNA.

Y. Liu, D. Liggitt, R. Debs, 2004, Molecular therapy : the journal of the American Society of Gene Therapy.

Non-replicating Epstein-Barr Virus-based Plasmids Extend Gene Expression and Can Improve Gene Therapy in Vivo *

D. Liggitt, S. Liu, A. Thor, 2000, The Journal of Biological Chemistry.

In vivo studies of gene expression via transient transgenesis using lipid-DNA delivery.

D. Liggitt, V. Watral, C. Bullock, 1999, DNA and cell biology.

Systemic gene expression after intravenous DNA delivery into adult mice.

D. Liggitt, R. Debs, Y. Liu, 1993, Science.

Tomographic magnetic particle imaging of cancer targeted nanoparticles.

Sanjiv Sam Gambhir, Katayoun Saatchi, Hamed Arami, 2017, Nanoscale.

In vivo delivery, pharmacokinetics, biodistribution and toxicity of iron oxide nanoparticles.

Kannan M. Krishnan, Hamed Arami, D. Liggitt, 2015, Chemical Society reviews.

Evaluation of vascular delivery methodologies to enhance rAAV6-mediated gene transfer to canine striated musculature.

James M. Allen, D. Liggitt, J. Chamberlain, 2009, Molecular therapy : the journal of the American Society of Gene Therapy.

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

C. Alpers, D. Liggitt, D. Rawlings, 2011 .

Opposing Impact of B Cell–Intrinsic TLR7 and TLR9 Signals on Autoantibody Repertoire and Systemic Inflammation

C. Alpers, D. Liggitt, Quanzhen Li, 2014, The Journal of Immunology.

Myelin-specific CD8 T cells exacerbate brain inflammation in CNS autoimmunity.

J. Goverman, D. Liggitt, C. A. Wagner, 2019, The Journal of clinical investigation.

Vaccinia Virus Infection of Mice Cellular and Humoral Immunity against Bevan

Aaron J. Johnson, D. Liggitt, M. Bevan, 2004 .

Local Blockade of Allergic Airway Hyperreactivity and Inflammation by the Poxvirus-Derived Pan-CC-Chemokine Inhibitor vCCI1

D. Liggitt, K. Dabbagh, D. Lewis, 2000, The Journal of Immunology.

Local Role for Tumor Necrosis Factor Alpha in the Pulmonary Inflammatory Response to Mycobacterium tuberculosis Infection

D. Liggitt, Christopher B Wilson, S. Skerrett, 2002, Infection and Immunity.

Trypanosoma cruzi trans-sialidase initiates a program independent of the transcription factors RORγt and Ahr that leads to IL-17 production by activated B cells

D. Liggitt, D. Rawlings, M. Oukka, 2013, Nature Immunology.

An evaluation of the functions of the 22-kilodalton (kDa), the 20-kDa, and the N-terminal polypeptide forms of human growth hormone using transgenic mice.

D. Liggitt, L. Martin, H. Oakley, 1992, Endocrinology.

Preclinical safety and effectiveness studies of ultrasonic propulsion of kidney stones.

Julianna C. Simon, Mathew D. Sorensen, F. Starr, 2014, Urology.

Trypanosoma cruzi trans-sialidase initiates an ROR-γt–AHR-independent program leading to IL-17 production by activated B cells

D. Liggitt, D. Rawlings, M. Oukka, 2013, Nature immunology.

Therapeutic and toxic activity of tumor necrosis factor is synergistic with gamma interferon.

D. Liggitt, J. Talmadge, O. Bowersox, 1989, Pathology and immunopathology research.

Development of partial tolerance to the gastrointestinal effects of high doses of recombinant tumor necrosis factor-alpha in rodents.

D. Liggitt, J. Patton, J. Mccabe, 1987, The Journal of clinical investigation.

Logic-Gated ROR1 Chimeric Antigen Receptor Expression Rescues T Cell-Mediated Toxicity to Normal Tissues and Enables Selective Tumor Targeting.

Shivani Srivastava, Robert H Pierce, Kimberly S Smythe, 2019, Cancer cell.

Viral-induced T helper type 1 responses enhance allergic disease by effects on lung dendritic cells

D. Liggitt, K. Dabbagh, D. Lewis, 2004, Nature Immunology.

ST-11: A New Brain-Penetrant Microtubule-Destabilizing Agent with Therapeutic Potential for Glioblastoma Multiforme

D. Liggitt, John D. Scott, Eric A. Horne, 2016, Molecular Cancer Therapeutics.

Characterization of vascular leak syndrome induced by the toxin component of Pseudomonas exotoxin-based immunotoxins and its potential inhibition with nonsteroidal anti-inflammatory drugs.

D. Liggitt, M. Steinitz, D. Chace, 1997, Clinical cancer research : an official journal of the American Association for Cancer Research.

Prevention of immunotoxin-mediated vascular leak syndrome in rats with retention of antitumor activity.

H. P. Fell, D. Liggitt, D. Chace, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Immunomodulatory and Toxic Effects of Free and Liposome-encapsulated Tumor Necrosis Factor α in Rats

D. Liggitt, J. Shellito, H. Fuchs, 1990 .

Inflammatory Destruction of Pancreatic Islets in Interferon Gamma Transgenic Mice

N. Sarvetnick, D. Liggitt, T. Stewart, 1989 .

Toxicity of tumor necrosis factor is synergistic with gamma-interferon and can be reduced with cyclooxygenase inhibitors.

D. Liggitt, J. Talmadge, H. Shepard, 1987, The American journal of pathology.

Histochemical Discrimination of Endogenous Mammalian β-galactosidase Activity from that Resulting from lac-Z Gene Expression

D. Liggitt, D. Weiss, Joan G. Clark, 1999, The Histochemical Journal.

In situ histochemical detection of beta-galactosidase activity in lung: assessment of X-Gal reagent in distinguishing lacZ gene expression and endogenous beta-galactosidase activity.

D. Liggitt, J. Clark, D. Weiss, 1997, Human gene therapy.

CD8+ T Cells Accumulate in the Lungs of Mycobacterium tuberculosis-Infected Kb−/−Db−/− Mice, But Provide Minimal Protection 1

D. Liggitt, M. Bevan, K. Urdahl, 2003, The Journal of Immunology.

Identification of gene function and functional pathways by systemic plasmid-based ribozyme targeting in adult mice

Yong Liu, D. Liggitt, A. Thor, 2002, Proceedings of the National Academy of Sciences of the United States of America.

Interleukin 4 expressed in situ selectively alters thymocyte development

R. Perlmutter, D. Liggitt, D. Lewis, 1991, The Journal of experimental medicine.

Pharmacokinetic parameters of recombinant mast cell growth factor (rMGF).

D. Williams, D. Liggitt, D. Lynch, 1992, Lymphokine and cytokine research.

Response to paper by Singh et al. "Hyperinsulinemia adversely affects lung structure and function".

D. Liggitt, J. Brain, R. Wolff, 2016, American journal of physiology. Lung cellular and molecular physiology.

Loss of pancreatic islet tolerance induced by β-cell expression of interferon-γ

N. Sarvetnick, D. Liggitt, T. Parslow, 1990, Nature.

Gene expression along the cerebral-spinal axis after regional gene delivery.

D. Liggitt, R. Debs, C. Meuli‐Simmen, 1999, Human gene therapy.

Gαq-containing G proteins regulate B cell selection and survival and are required to prevent B cell–dependent autoimmunity

Ravi S. Misra, M. Simon, C. Alpers, 2010, The Journal of experimental medicine.

Increased Ribonuclease Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

C. Alpers, D. Liggitt, K. Elkon, 2013, The Journal of Immunology.

Increased RNase Expression Reduces Inflammation and Prolongs Survival in TLR7 Transgenic Mice

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Inflammation and Prolongs Survival in Increased Ribonuclease Expression Reduces

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Transgenic TLR7 Inflammation and Prolongs Survival in Increased RNase Expression Reduces

C. Alpers, D. Liggitt, K. Elkon, 2013 .

Antitumor Activity When Administered Activation of Innate Immune Responses and Lipid-DNA Complexes Induce Potent

D. Liggitt, T. Potter, T. Heath, 2013 .

Type I interferons potently suppress gene expression following gene delivery using liposome(-)DNA complexes.

D. Liggitt, L. Fradkin, S. Dow, 2005, Molecular therapy : the journal of the American Society of Gene Therapy.

Phase I study of liposome-DNA complexes encoding the interleukin-2 gene in dogs with osteosarcoma lung metastases.

D. Liggitt, S. Dow, F. Pericle, 2005, Human gene therapy.

Fetal gene transfer by transuterine injection of cationic liposome–DNA complexes

D. Liggitt, R. Debs, T. Heath, 1999, Nature Biotechnology.

Intravenously Antitumor Activity When Administered Activation of Innate Immune Responses and Lipid-DNA Complexes Induce Potent Willson

D. Liggitt, T. Potter, T. Heath, 1999 .

In vivo gene delivery. Efficient transfection of T lymphocytes in adult mice.

D. Liggitt, R. Debs, P. Dazin, 1993, The Journal of biological chemistry.

Aerosol gene delivery in vivo.

D. Liggitt, R. Debs, E. Brunette, 1992, Proceedings of the National Academy of Sciences of the United States of America.

Ultraviolet B Irradiation Causes Stimulator of Interferon Genes–Dependent Production of Protective Type I Interferon in Mouse Skin by Recruited Inflammatory Monocytes

D. Liggitt, K. Elkon, C. Sontheimer, 2017, Arthritis & rheumatology.

WASp-deficient B cells play a critical, cell-intrinsic role in triggering autoimmunity

C. Alpers, D. Liggitt, D. Rawlings, 2011, The Journal of experimental medicine.

Loss of pancreatic islet tolerance induced by beta-cell expression of interferon-gamma.

N. Sarvetnick, D. Liggitt, T. Parslow, 1990, Nature.

Durable multitransgene expression in vivo using systemic, nonviral DNA delivery

Y. Liu, D. Liggitt, D. Lewis, 2019, Science Advances.

Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance

J. Goverman, D. Liggitt, E. Huseby, 2006 .

, Xiaoxia Infection Mycobacterium tuberculosis toin the Pulmonary Inflammatory Response Local Role for Tumor Necrosis Factor Alpha

D. Liggitt, Christopher B Wilson, S. Skerrett, 2002 .

Lung-specific delivery of cytokines induces sustained pulmonary and systemic immunomodulation in rats.

D. Liggitt, J. Shellito, H. Fuchs, 1988, Journal of immunology.

Developmental pattern of the expression of malonyl-CoA decarboxylase gene and the production of unique lipids in the goose uropygial glands.

D. Liggitt, L. Rogers, P. Kolattukudy, 1987, Archives of biochemistry and biophysics.

Efficient gene expression in skin wound sites following local plasmid injection.

D. Liggitt, M. Kashani-Sabet, R. Debs, 2001, The Journal of investigative dermatology.

Pancreatic islet-specific engineered Tregs exhibit robust antigen-specific and bystander immune suppression in type 1 diabetes models

P. Linsley, D. Liggitt, D. Rawlings, 2022, Science Translational Medicine.

Suppressor of cytokine signaling expression with increasing severity of murine hepatic ischemia-reperfusion injury.

D. Liggitt, Jean S. Campbell, N. Fausto, 2008, Journal of hepatology.

The Geropathology Research Network: An Interdisciplinary Approach for Integrating Pathology Into Research on Aging.

D. Liggitt, M. Ciol, R. McIndoe, 2016, The journals of gerontology. Series A, Biological sciences and medical sciences.

Pathology is a critical aspect of preclinical aging studies

D. Liggitt, P. Treuting, W. Ladiges, 2013, Pathobiology of aging & age related diseases.

Use of perfluorochemical liquid allows earlier detection of gene expression and use of less vector in normal lung and enhances gene expression in acutely injured lung.

D. Liggitt, D. Weiss, L. Bonneau, 2001, Molecular therapy : the journal of the American Society of Gene Therapy.

Testing drug combinations to slow aging

D. Liggitt, W. Ladiges, 2017, Pathobiology of aging & age related diseases.

Cytokine-Regulated Neutrophil Recruitment Is Required for Brain but Not Spinal Cord Inflammation during Experimental Autoimmune Encephalomyelitis

J. Goverman, D. Liggitt, Sarah B. Simmons, 2014, The Journal of Immunology.

Perflubron enhances adenovirus-mediated gene expression in lungs of transgenic mice with chronic alveolar filling.

D. Liggitt, J. Clark, T. Strandjord, 1999, Human gene therapy.

Insulin-dependent diabetes mellitus induced in transgenic mice by ectopic expression of class II MHC and interferon-gamma

N. Sarvetnick, D. Liggitt, S. L. Pitts, 1988, Cell.

A phase I study of concurrent chemotherapy (paclitaxel and carboplatin) and thoracic radiotherapy with swallowed manganese superoxide dismutase plasmid liposome protection in patients with locally advanced stage III non-small-cell lung cancer.

J. Luketich, D. Liggitt, S. Ramalingam, 2010, Human gene therapy.

Inhalation of nebulized perfluorochemical enhances recombinant adenovirus and adeno-associated virus-mediated gene expression in lung epithelium.

Lili Wang, A. Howard, J. Blanchard, 2012, Human gene therapy methods.

Plasmid/liposome transfer of the human manganese superoxide dismutase transgene prevents ionizing irradiation‐induced apoptosis in human esophagus organ explant culture

J. Luketich, D. Liggitt, J. Greenberger, 2000, International journal of cancer.

Hepatocellular Heme Oxygenase-1: A Potential Mechanism of Erythropoietin-Mediated Protection After Liver Ischemia-Reperfusion Injury

D. Liggitt, Jean S. Campbell, K. Riehle, 2014, Shock.

A non-coding cationic lipid DNA complex produces lasting anti-leukemic effects

D. Liggitt, Zachary Herse, D. Claxton, 2010, Cancer biology & therapy.

Plasma Proteome Profiles Associated with Inflammation, Angiogenesis, and Cancer

Jacob Kennedy, Hong Wang, Christopher J. Kemp, 2011, PloS one.

A New Preclinical Paradigm for Testing Anti-Aging Therapeutics

D. Liggitt, M. Ciol, D. Imai, 2017, The journals of gerontology. Series A, Biological sciences and medical sciences.

A Pathogenic Role for Myelin-Specific Cd8+ T Cells in a Model for Multiple Sclerosis

J. Goverman, D. Liggitt, E. Huseby, 2001, The Journal of experimental medicine.

Safe and Effective Gene Therapy for Murine Wiskott-Aldrich Syndrome Using an Insulated Lentiviral Vector

D. Liggitt, A. Nienhuis, D. Rawlings, 2016, Molecular therapy. Methods & clinical development.

Focused ultrasound to displace renal calculi: threshold for tissue injury

F. Starr, A. Evan, J. Mcateer, 2014, Journal of therapeutic ultrasound.

B cell-specific lentiviral gene therapy leads to sustained B-cell functional recovery in a murine model of X-linked agammaglobulinemia.

D. Liggitt, B. Ryu, D. Rawlings, 2010, Blood.

Interleukin-7 improves reconstitution of antiviral CD4 T cells.

T. Kalina, D. Maloney, D. Liggitt, 2005, Clinical immunology.

Liposome–DNA complexes infused intravenously inhibit tumor angiogenesis and elicit antitumor activity in dogs with soft tissue sarcoma

D. Liggitt, S. Dow, A. Guth, 2006, Cancer Gene Therapy.

Impaired function of bovine alveolar macrophages infected with parainfluenza-3 virus.

D. Liggitt, J. Evermann, E. Trigo, 1985, American journal of veterinary research.

CD4+ T cells that express high levels of CD45RB induce wasting disease when transferred into congenic severe combined immunodeficient mice. Disease development is prevented by cotransfer of purified CD4+ T cells

J. Watson, D. Liggitt, P. Morrissey, 1993, The Journal of experimental medicine.

Differential regulation of central nervous system autoimmunity by TH1 and TH17 cells

J. Goverman, D. Liggitt, R. Harris, 2008, Nature Medicine.

Distinct roles for p53, p27Kip1, and p21Cip1 during tumor development

D. Liggitt, G. Longton, C. Kemp, 2004, Oncogene.

Modulation of Radiation-Induced Cytokine Elevation Associated with Esophagitis and Esophageal Stricture by Manganese Superoxide Dismutase-Plasmid/Liposome (SOD2-PL) Gene Therapy

D. Liggitt, J. Greenberger, G. Koe, 2001, Radiation research.

Targeted disruption of the low-affinity leukemia inhibitory factor receptor gene causes placental, skeletal, neural and metabolic defects and results in perinatal death.

C. Ware, D. Liggitt, J. Peschon, 1995, Development.

Pathway-specific tumor suppression. Reduction of p27 accelerates gastrointestinal tumorigenesis in Apc mutant mice, but not in Smad3 mutant mice.

D. Liggitt, G. Longton, C. Kemp, 2002, Cancer cell.

Intravenous cytokine gene delivery by lipid-DNA complexes controls the growth of established lung metastases.

D. Liggitt, T. Potter, T. Heath, 1999, Human gene therapy.

Lipid-DNA complexes induce potent activation of innate immune responses and antitumor activity when administered intravenously.

D. Liggitt, T. Potter, T. Heath, 1999, Journal of immunology.

Cationic Liposome-mediated Intravenous Gene Delivery (*)

D. Liggitt, R. Debs, G. Tu, 1995, The Journal of Biological Chemistry.

Cellular mechanisms of fatal early-onset autoimmunity in mice with the T cell-specific targeting of transforming growth factor-beta receptor.

A. Rudensky, D. Liggitt, J. Marie, 2006, Immunity.

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

I. Shmulevich, Victor V Lobanenkov, G. Filippova, 2014, Cell reports.

Relapsing–Remitting Central Nervous System Autoimmunity Mediated by GFAP-Specific CD8 T Cells

Bjoern Peters, D. Liggitt, V. Vanguri, 2014, The Journal of Immunology.

Humoral immune responses in CD40 ligand-deficient mice

R J Armitage, D. Liggitt, C. Maliszewski, 1994, The Journal of experimental medicine.

Targeting NOTCH activation in small cell lung cancer through LSD1 inhibition

C. Rudin, D. Liggitt, Wei-Yi Cheng, 2019, Science Signaling.

A disease-associated PTPN22 variant promotes systemic autoimmunity in murine models.

R. Moon, D. Liggitt, Alejandro Wolf-Yadlin, 2013, The Journal of clinical investigation.

Reproductive Biology and Endocrinology Open Access Late Gestation Modulation of Fetal Glucocorticoid Effects Requires the Receptor for Leukemia Inhibitory Factor: an Observational Study

Angelique M. Nelson, C. Ware, D. Liggitt, 2003 .

Topical gene delivery to murine skin.

D. Liggitt, M. Kashani-Sabet, R. Debs, 1999, The Journal of investigative dermatology.

The A946T variant IFIH1 RNA sensor mediates an interferon program that limits viral infection but increases the risk for autoimmunity

D. Liggitt, P. Concannon, D. Rawlings, 2017, Nature Immunology.

Host Nitric Oxide Disrupts Microbial Cell-to-Cell Communication to Inhibit Staphylococcal Virulence.

D. Liggitt, F. Fang, S. Libby, 2018, Cell host & microbe.

In vivo Delivery, Pharmacokinetics, Biodistribution and Toxicity of Iron Oxide Nanoparticles

Kannan M. Krishnan, Amit P. Khandhar, Hamed Arami, 2016 .

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression

Yong Liu, D. Liggitt, A. Thor, 2010, Proceedings of the National Academy of Sciences.

Cellular and Humoral Immunity against Vaccinia Virus Infection of Mice 1

Aaron J. Johnson, D. Liggitt, M. Bevan, 2004, The Journal of Immunology.

B Cells Drive MHC Class I–Restricted CD4 T Cells to Induce Spontaneous Central Nervous System Autoimmunity

J. Goverman, D. Liggitt, Aubry L. Matter, 2022, The Journal of Immunology.

Enhancement of simian varicella virus infection in African green monkeys by recombinant human tumor necrosis factor alpha.

D. Liggitt, K. Soike, G. Baskin, 1989, The Journal of infectious diseases.

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression (Proceedings of the National Academy Sciences of the United States of America (2010) 107, 43 (18616-18621))

D. Liggitt, A. Thor, H. DeLisser, 2011 .

The use of the AMS800 artificial urinary sphincter in combination with the gastric tube for continence in the canine model.

D. Liggitt, M. Burns, M. Mitchell, 1993, The Journal of urology.

Systemic co-administration of depsipeptide selectively targets transfection enhancement to specific tissues and cell types

D. Liggitt, R. Debs, S. Fong, 2006, Gene Therapy.

Regulatory T Cells Maintain Long-Term Tolerance to Myelin Basic Protein by Inducing a Novel, Dynamic State of T Cell Tolerance1

J. Goverman, D. Liggitt, Eric S. Huseby, 2007, The Journal of Immunology.

Anti-P-selectin monoclonal antibody attenuates reperfusion injury to the rabbit ear.

D. Liggitt, J. Paulson, J. Harlan, 1993, The Journal of clinical investigation.

Mechanical ventilation interacts with endotoxemia to induce extrapulmonary organ dysfunction

D. Liggitt, W. Altemeier, T. Martin, 2006, Critical care.

Cutting Edge: Systemic Autoimmunity in Murine STAT3 Gain-of-Function Syndrome Is Characterized by Effector T Cell Expansion in the Absence of Overt Regulatory T Cell Dysfunction

D. Liggitt, D. Rawlings, M. Oukka, 2022, The Journal of Immunology.

Male-specific beta-cell dysfunction and diabetes resulting from increased expression of a syngeneic MHC class I protein in the pancreata of transgenic mice.

D. Liggitt, L. Martin, H. Oakley, 1990, The New biologist.

An adult dog with cyclic neutropenia treated by lentivirus- mediated delivery of granulocyte colony-stimulating factor.

D. Liggitt, D. Dale, O. Yanay, 2006, Human Gene Therapy.

The Autoimmune Risk R262W Variant of the Adaptor SH2B3 Improves Survival in Sepsis.

M. Wurfel, D. Liggitt, D. Rawlings, 2021, Journal of Immunology.

Neuropathological assessment and validation of mouse models for Alzheimer's disease: applying NIA-AA guidelines

D. Liggitt, M. Darvas, C. Sigurdson, 2016, Pathobiology of aging & age related diseases.

Isoform‐specific knockout of FE65 leads to impaired learning and memory

C. Ware, D. Storm, D. Liggitt, 2004, Journal of Neuroscience Research.

Mice, But Provide Minimal Protection - / - b D - / - b -Infected K Mycobacterium tuberculosis T Cells Accumulate in the Lungs of + CD8

D. Liggitt, M. Bevan, K. Urdahl, 2003 .

3aBAb5. Ultrasound intensity to propel stones from the kidney is below the threshold for renal injury.

Mathew D. Sorensen, F. Starr, A. Evan, 2013, Proceedings of meetings on acoustics. Acoustical Society of America.

Vascular endothelial platelet endothelial cell adhesion molecule 1 (PECAM-1) regulates advanced metastatic progression

Yong Liu, D. Liggitt, A. Thor, 2010, Proceedings of the National Academy of Sciences.

CTCF haploinsufficiency destabilizes DNA methylation and predisposes to cancer.

I. Shmulevich, Victor V Lobanenkov, G. Filippova, 2014, Cell reports.