P. Iversen

发表

Lipoxygenase inhibitors abolish proliferation of human pancreatic cancer cells.

X. Ding, P. Iversen, M. Cluck, 1999, Biochemical and biophysical research communications.

Oligonucleotide Enhanced Cytotoxicity of Idarubicin for Lymphoma Cells

T. Greiner, J. Vose, P. Iversen, 2001, Leukemia & lymphoma.

Phase I trial of an antisense oligonucleotide OL(1)p53 in hematologic malignancies.

T. Greiner, P. Iversen, G. Zon, 1996, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pharmacology and toxicology of phosphorothioate oligonucleotides in the mouse, rat, monkey and man.

P. Iversen, B. Copple, H. K. Tewary, 1995, Toxicology letters.

Oligonucleotides in the treatment of leukemia

P. Iversen, E. Bayever, 1994, Hematological oncology.

Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism

P. Iversen, A. Annalora, C. Marcus, 2017, Drug Metabolism and Disposition.

Inhibition of Coxsackievirus B3 in Cell Cultures and in Mice by Peptide-Conjugated Morpholino Oligomers Targeting the Internal Ribosome Entry Site

D. A. Stein, P. Iversen, H. Moulton, 2006, Journal of Virology.

Inhibition of Gene Expression in Escherichia coli by Antisense Phosphorodiamidate Morpholino Oligomers

D. A. Stein, P. Iversen, H. Moulton, 2003, Antimicrobial Agents and Chemotherapy.

Inhibition of dengue virus translation and RNA synthesis by a morpholino oligomer targeted to the top of the terminal 3' stem-loop structure.

D. A. Stein, T. Pierson, E. Harris, 2006, Virology.

Pharmacokinetics, biodistribution, stability and toxicity of a cell-penetrating peptide-morpholino oligomer conjugate.

P. Iversen, H. Moulton, M. T. Reddy, 2007, Bioconjugate chemistry.

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

Resistance to chemotherapeutic drugs overcome by c-Myc inhibition in a Lewis lung carcinoma murine model

P. Iversen, G. Devi, M. T. Reddy, 2003, Anti-cancer drugs.

HIV Tat peptide enhances cellular delivery of antisense morpholino oligomers.

P. Iversen, H. Moulton, Michelle C Hase, 2003, Antisense & nucleic acid drug development.

Inhibition of replication and transcription activator and latency-associated nuclear antigen of Kaposi's sarcoma-associated herpesvirus by morpholino oligomers

D. A. Stein, P. Iversen, H. Moulton, 2006, Antiviral Research.

Discovery and Early Development of AVI-7537 and AVI-7288 for the Treatment of Ebola Virus and Marburg Virus Infections

P. Iversen, S. Bavari, R. Panchal, 2012, Viruses.

Vectorization of morpholino oligomers by the (R-Ahx-R)4 peptide allows efficient splicing correction in the absence of endosomolytic agents.

P. Iversen, H. Moulton, B. Lebleu, 2006, Journal of controlled release : official journal of the Controlled Release Society.

Inhibition of Vesivirus infections in mammalian tissue culture with antisense morpholino oligomers.

D. A. Stein, P. Iversen, A. W. Smith, 2001, Antisense & nucleic acid drug development.

Induction of revertant fibres in the mdx mouse using antisense oligonucleotides

P. Iversen, S. Wilton, S. Fletcher, 2006, Genetic vaccines and therapy.

Antiviral Effects of Antisense Morpholino Oligomers in Murine Coronavirus Infection Models

D. A. Stein, B. Neuman, M. Buchmeier, 2007, Journal of Virology.

X-linked inhibitor of apoptosis protein inhibition induces apoptosis and enhances chemotherapy sensitivity in human prostate cancer cells.

P. Iversen, G. Devi, A. Amantana, 2004, Molecular Cancer Therapeutics.

The role of primer recognition proteins in DNA replication: inhibition of cellular proliferation by antisense oligodeoxyribonucleotides.

P. Iversen, J. Vishwanatha, K. Kumble, 1992, Journal of cell science.

The mechanism of inhibition of cytochrome P450IIE1 by dihydrocapsaicin

P. Iversen, P. Gannett, T. Lawson, 1990 .

In vivo studies with phosphorothioate oligonucleotides: pharmacokinetics prologue.

P. Iversen, 1991, Anti-cancer drug design.

Systemic administration of a phosphorothioate oligonucleotide with a sequence complementary to p53 for acute myelogenous leukemia and myelodysplastic syndrome: initial results of a phase I trial.

P. Iversen, G. Zon, R. Ruddon, 1993, Antisense research and development.

Inactivated COVID-19 vaccines to make a global impact

P. Iversen, S. Bavari, 2021, The Lancet Infectious Diseases.

Eastern Equine Encephalitis Virus Rapidly Infects and Disseminates in the Brain and Spinal Cord of Infected Cynomolgus Macaques Following Aerosol Challenge

P. Iversen, S. Bavari, Janice A. Williams, 2020, bioRxiv.

Cardiovascular effects of a phosphorothioate oligonucleotide with sequence antisense to p53 in the conscious rhesus monkey

Larry J. Smith, P. Iversen, E. Bayever, 1993 .

Cholesteryl-conjugated phosphorothioate oligodeoxynucleotides modulate CYP2B1 expression in vivo.

P. Iversen, G. Zon, J. Mata, 1995, Journal of drug targeting.

Metallothionein in carcinogenesis and cancer chemotherapy.

P. Iversen, M. Ebadi, Manuchair Ebadi, 1994, General pharmacology.

Gene-Specific Countermeasures against Ebola Virus Based on Antisense Phosphorodiamidate Morpholino Oligomers

D. A. Stein, P. Iversen, M. Aman, 2006, PLoS pathogens.

AN IN VITRO MODEL FOR ENDOTHELIAL PERMEABILITY: ASSESSMENT OF

P. Iversen, M. Cano, Monolayer Integrity, 1995 .

Pharmacokinetics and in vivo effects of a six-base phosphorothioate oligodeoxynucleotide with anticancer and hematopoietic activities in swine.

P. Iversen, J. Jackson, M. Bishop, 2000, Journal of hematotherapy & stem cell research.

Active Specific Immunotherapy with a β-Human Chorionic Gonadotropin Peptide Vaccine in Patients with Metastatic Colorectal Cancer: Antibody Response Is Associated with Improved Survival

P. Iversen, H. Moulton, P. Triozzi, 2002 .

Active specific immunotherapy with a beta-human chorionic gonadotropin peptide vaccine in patients with metastatic colorectal cancer: antibody response is associated with improved survival.

P. Iversen, H. Moulton, P. Triozzi, 2002, Clinical cancer research : an official journal of the American Association for Cancer Research.

Bioavailability and efficacy of antisense morpholino oligomers targeted to c-myc and cytochrome P-450 3A2 following oral administration in rats.

P. Iversen, M. T. Reddy, D. Weller, 2002, Journal of pharmaceutical sciences.

Neutrally charged phosphorodiamidate morpholino antisense oligomers: uptake, efficacy and pharmacokinetics.

P. Iversen, G. Devi, V. Arora, 2004, Current pharmaceutical biotechnology.

In vivo Bioavailability and Pharmacokinetics of a c-MYC Antisense Phosphorodiamidate Morpholino Oligomer, AVI-4126, in Solid Tumors

P. Iversen, C. Corless, G. Devi, 2005, Clinical Cancer Research.

Depleting regulatory T cells with arginine-rich, cell-penetrating, peptide-conjugated morpholino oligomer targeting FOXP3 inhibits regulatory T-cell function

P. Iversen, K. Aird, M. Morse, 2011, Cancer Gene Therapy.

c-MYC antisense phosphosphorodiamidate morpholino oligomer inhibits lung metastasis in a murine tumor model.

P. Iversen, H. Sekhon, G. Devi, 2008, Lung cancer.

Bmc Molecular Biology Antisense Oligonucleotide Induced Exon Skipping and the Dystrophin Gene Transcript: Cocktails and Chemistries

P. Iversen, S. Wilton, S. Fletcher, 2022 .

Induced dystrophin exon skipping in human muscle explants

P. Iversen, H. Moulton, S. Wilton, 2006, Neuromuscular Disorders.

c-myc antisense oligonucleotide treatment ameliorates murine ARPKD.

P. Iversen, V. Gattone, J. Mata, 2002, Kidney international.

Local application of antisense for prevention of restenosis.

N. Kipshidze, J. Moses, M. Leon, 2005, Methods in molecular medicine.

Androgen receptor down-regulation in prostate cancer with phosphorodiamidate morpholino antisense oligomers.

P. Iversen, G. Bubley, G. Devi, 2004, The Journal of urology.

Evaluation of antisense mechanisms of action.

P. Iversen, C. Ghosh, D. Weller, 2000, Methods in enzymology.

Qualitative and quantitative measurements of oligonucleotides in gene therapy: Part II in vivo models.

P. Iversen, H. K. Tewary, 1997, Journal of pharmaceutical and biomedical analysis.

Suppression of Philadelphia1 leukemia cell growth in mice by BCR-ABL antisense oligodeoxynucleotide.

P. Iversen, G. Zon, B. Calabretta, 1994, Proceedings of the National Academy of Sciences of the United States of America.

Synergy of phenobarbital and 3-methylcholanthrene in "superinduction" of cytochrome P-450c mRNA but not enzyme activity.

P. Iversen, E. Bresnick, L. I. Siegel, 1987, Biochemical pharmacology.

Selective changes in cytochrome P-450 and UDP-glucuronosyltransferase subpopulations following partial hepatectomy in rats.

P. Iversen, M. Franklin, Z. Liu, 1985, Toxicology and applied pharmacology.

Microsomal cytochrome P-450 "handprints": five fractions from anion-exchange high-pressure liquid chromatography provide a rapid preliminary screen for selectivity in the induction and destruction of rat hepatic cytochrome P-450 subpopulations.

P. Iversen, M. Franklin, 1985, Toxicology and applied pharmacology.

Oligonucleotides complementary to c-myb messenger RNA inhibit growth and induce apoptosis in human Burkitt lymphoma cells.

P. Iversen, M. Bishop, J. Sharp, 1996, International journal of oncology.

Ex vivo treatment of bone marrow with phosphorothioate oligonucleotide OL(1)p53 for autologous transplantation in acute myelogenous leukemia and myelodysplastic syndrome.

P. Iversen, J. Jackson, J. Sharp, 1997, Journal of hematotherapy.

Antisense oligonucleotide OL (1) p53 for in vitro purging of autologous bone marrow in acute myelogenous leukemia.

P. Iversen, J. Jackson, M. Bishop, 1994, Progress in clinical and biological research.

A hexameric phosphorothioate oligonucleotide telomerase inhibitor arrests growth of Burkitt's lymphoma cells in vitro and in vivo.

P. Iversen, J. Jackson, T. Page, 1997, Toxicology and applied pharmacology.

Preparation of 35S-labeled polyphosphorothioate oligodeoxyribonucleotides by use of hydrogen phosphonate chemistry.

W. Stec, P. Iversen, G. Zon, 1990, Analytical biochemistry.

An experimental model for interpreting percutaneous penetration of oligonucleotides that incorporates the role of keratinocytes.

P. Iversen, R. Brand, K. Haase, 1998, The Journal of investigative dermatology.

In vivo modulation of the rat cytochrome P450 1A1 by double-stranded phosphorothioate oligodeoxynucleotides.

P. Iversen, W. Tracewell, J. Desjardins, 1995, Toxicology and applied pharmacology.

Increased growth inhibition of human chronic myelogenous leukemic cells by a combination of c-myb antisense oligonucleotide and 4-hydroxyperoxycyclophosphamide in vitro.

P. Iversen, M. Bishop, S. Joshi, 1997, International journal of oncology.

Transdermal delivery of phosphorodiamidate Morpholino oligomers across hairless mouse skin.

P. Iversen, A. Pannier, R. Brand, 2004, International journal of pharmaceutics.

The cytotoxic effects of single-stranded telomere mimics on OMA-BL1 cells.

P. Iversen, T. Page, J. Neff, 1999, Experimental cell research.

Combination of antisense oligonucleotide and low-dose chemotherapy in hematological malignancies.

P. Iversen, M. Bishop, S. Joshi, 1997, Journal of pharmacological and toxicological methods.

Antisense Morpholino-Oligomers Directed against the 5′ End of the Genome Inhibit Coronavirus Proliferation and Growth†

D. A. Stein, B. Neuman, M. Buchmeier, 2004, Journal of Virology.

Characterization of binding sites, extent of binding, and drug interactions of oligonucleotides with albumin.

P. Iversen, H. K. Tewary, S. Srinivasan, 1995, Antisense research and development.

Manipulation of metallothionein expression in the regenerating rat liver using antisense oligonucleotides.

P. Iversen, M. Ebadi, V. Arora, 1998, Biochemical and biophysical research communications.

Antisense and ODN Transcription Factors in the Treatment of Vascular Proliferative Disease

N. Kipshidze, G. Dangas, M. Tsapenko, 2007 .

Intramural coronary delivery of advanced antisense oligonucleotides reduces neointimal formation in the porcine stent restenosis model.

G. Stone, N. Kipshidze, G. Dangas, 2002, Journal of the American College of Cardiology.

Induced IL-10 splice altering approach to antiviral drug discovery.

Steven B. Bradfute, P. Iversen, S. Bavari, 2014, Nucleic acid therapeutics.

Chemical modifications to phosphodiamidate morpholino oligomer antisense molecules targeting VP 224 modify their efficacy against Ebola virus infection

G. Ruthel, P. Iversen, H. Moulton, 2009 .

Effects of BCR-ABL antisense oligonucleotides (AS-ODN) on human chronic myeloid leukemic cells: AS-ODN as effective purging agents.

W. Chan, W. Sanger, P. Iversen, 1995, Leukemia & lymphoma.

Inhibition of infectious haematopoietic necrosis virus in cell cultures with peptide‐conjugated morpholino oligomers

D. A. Stein, P. Iversen, H. Moulton, 2005, Journal of fish diseases.

Inhibition of carotid artery neointimal formation with intravenous microbubbles.

P. Iversen, S. Radio, U. Deligonul, 2001, Ultrasound in medicine & biology.

Minireview Alternative Splicing in the Cytochrome P450 Superfamily Expands Protein Diversity to Augment Gene Function and Redirect Human Drug Metabolism s

P. Iversen, A. Annalora, C. Marcus, 2017 .

Arginine-rich cell-penetrating peptide dramatically enhances AMO-mediated ATM aberrant splicing correction and enables delivery to brain and cerebellum.

P. Iversen, R. Gatti, R. Kayali, 2011, Human molecular genetics.

Effective rescue of dystrophin improves cardiac function in dystrophin-deficient mice by a modified morpholino oligomer

P. Iversen, H. Moulton, Juan Li, 2008, Proceedings of the National Academy of Sciences.

Cellular uptake and subcellular distribution of phosphorothioate oligonucleotides into cultured cells.

P. Iversen, G. Zon, A. Meyer, 1992, Antisense research and development.

Inhibition of alphavirus infection in cell culture and in mice with antisense morpholino oligomers

D. A. Stein, N. Dziuba, P. Iversen, 2008, Virology.

Inhibition and Escape of SARS-CoV Treated with Antisense Morpholino Oligomers

D. A. Stein, B. Neuman, M. Buchmeier, 2006, Advances in experimental medicine and biology.

In vivo evaluation of a morpholino antisense oligomer directed against tumor necrosis factor-alpha.

P. Iversen, L. Kobzik, G. Qin, 2000, Antisense & nucleic acid drug development.

Development of Novel Bioanalytical Methods to Determine the Effective Concentrations of Phosphorodiamidate Morpholino Oligomers in Tissues and Cells

P. Iversen, D. Mourich, F. Schnell, 2013, BioResearch open access.

Inhibition of p53 expression by peptide-conjugated phosphorodiamidate morpholino oligomers sensitizes human cancer cells to chemotherapeutic drugs

P. Iversen, S. Benchimol, Y. Lin, 2012, Oncogene.

INHIBITION OF RESPIRATORY SYNCYTIAL VIRUS INFECTION IN CELL CULTURES AND IN MICE WITH MORPHOLINO OLIGOMERS

Teodora, D. A. Stein, P. Iversen, 2011 .

Antisense targeting of cFLIP sensitizes activated T cells to undergo apoptosis and desensitizes responses to contact dermatitis.

P. Iversen, N. Marshall, D. Hinrichs, 2009, The Journal of investigative dermatology.

Delivery of steric block morpholino oligomers by (R-X-R)4 peptides: structure–activity studies

P. Iversen, H. Moulton, B. Lebleu, 2008, Nucleic acids research.

Morpholino oligomers targeting the PB1 and NP genes enhance the survival of mice infected with highly pathogenic influenza A H7N7 virus.

D. A. Stein, H. Klenk, P. Iversen, 2008, The Journal of general virology.

Peptide-conjugated morpholino oligomers inhibit porcine reproductive and respiratory syndrome virus replication

D. A. Stein, T. Opriessnig, P. Halbur, 2007, Antiviral Research.

Virus-specific antiviral treatment for controlling severe and fatal outbreaks of feline calicivirus infection.

P. Iversen, D. Matson, P. O'Hanley, 2008, American journal of veterinary research.

Inhibition of Foot-and-Mouth Disease Virus Infections in Cell Cultures with Antisense Morpholino Oligomers

D. A. Stein, P. Iversen, A. Vagnozzi, 2007, Journal of Virology.

Cell-penetrating peptide-morpholino conjugates alter pre-mRNA splicing of DMD (Duchenne muscular dystrophy) and inhibit murine coronavirus replication in vivo.

D. A. Stein, B. Neuman, M. Buchmeier, 2007, Biochemical Society transactions.

Gene-Specific Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture

P. Iversen, Lucas D. Tilley, D. Weller, 2006, Antimicrobial Agents and Chemotherapy.

Suppression of porcine reproductive and respiratory syndrome virus replication by morpholino antisense oligomers

D. A. Stein, P. Iversen, Yanjin Zhang, 2006, Veterinary Microbiology.

Gene-Speciﬁc Effects of Antisense Phosphorodiamidate Morpholino Oligomer-Peptide Conjugates on Escherichia coli and Salmonella enterica Serovar Typhimurium in Pure Culture and in Tissue Culture

P. Iversen, Lucas D. Tilley, D. Weller, 2006 .

Antisense Phosphorodiamidate Morpholino Oligomer Length and Target Position Effects on Gene-Specific Inhibition in Escherichia coli

P. Iversen, B. Geller, J. Deere, 2005, Antimicrobial Agents and Chemotherapy.

Phosphorodiamidate Morpholino Oligomers

P. Iversen, 2001, Antisense Drug Technology.

Structural details of the human cytochrome P-450c gene.

P. Iversen, E. Bresnick, R. Hines, 1987, Archives of biochemistry and biophysics.

Inhibition of Cytochrome P 450 and Multidrug Resistance Proteins Potentiates the Efficacy of All- Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo

P. Iversen, T. Adrian, T. El-Abaseri, 2016 .

Morpholino oligomer-mediated exon skipping averts the onset of dystrophic pathology in the mdx mouse.

P. Iversen, H. Moulton, S. Wilton, 2007, Molecular therapy : the journal of the American Society of Gene Therapy.

Interaction of diagnostic ultrasound with synthetic oligonucleotide‐labeled perfluorocarbon‐exposed sonicated dextrose albumin microbubbles.

P. Iversen, T. Porter, F. Xie, 1996, Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine.

Pharmacokinetics of an antisense phosphorothioate oligodeoxynucleotide against rev from human immunodeficiency virus type 1 in the adult male rat following single injections and continuous infusion.

P. Iversen, G. Zon, J. Mata, 1994, Antisense research and development.

Preparation of Oligomeric 2′-Deoxy-5-Fluorouridylate of Defined Length and Backbone Composition: A Novel Pro-Drug form of the Potent Anti-Cancer Drug 2′-Deoxy-5-Fluorouridylate

P. Iversen, W. Gmeiner, R. Pon, 1995 .

Benzimidazoisoquinolines: A New Class of Rapidly Metabolized Aryl Hydrocarbon Receptor (AhR) Ligands that Induce AhR-Dependent Tregs and Prevent Murine Graft-Versus-Host Disease

P. Iversen, N. Kerkvliet, S. Punj, 2014, PloS one.

Lymphocytic Choriomeningitis Virus Infection in FVB Mouse Produces Hemorrhagic Disease

P. Iversen, D. Mourich, F. Schnell, 2012, PLoS pathogens.

HIV-1 rev antisense phosphorothioate oligonucleotide binding to human mononuclear cells is cell type specific and inducible.

P. Iversen, G. Zon, S. Pirruccello, 1994, Antisense research and development.

By‐passing the nonsense mutation in the 4CV mouse model of muscular dystrophy by induced exon skipping

P. Iversen, S. Wilton, S. Fletcher, 2009, The journal of gene medicine.

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

P. Iversen, R. Kole, H. Moulton, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Selective inhibition of alpha1B-adrenergic receptor expression and function using a phosphorothioate antisense oligodeoxynucleotide.

P. Iversen, W. B. Jeffries, P. Gonzalez-Cabrera, 1998, Molecular pharmacology.

Tumor cell growth is inhibited by suppressing metallothionein-I synthesis.

P. Iversen, S. Okada, A. Takeda, 1997, Cancer letters.

The Threat from Viruses

P. Iversen, 2018, Molecular Basis of Resilience.

Cellular uptake of antisense morpholino oligomers conjugated to arginine-rich peptides.

P. Iversen, H. Moulton, M. T. Reddy, 2004, Bioconjugate chemistry.

Photoactivation of Vascular iNOS and Elevation of cGMP In Vivo: Possible Mechanism for Photovasorelaxation and Inhibition of Restenosis in an Atherosclerotic Rabbit Model ¶

N. Kipshidze, J. Moses, M. Leon, 2000, Photochemistry and photobiology.

Effects of systemic multiexon skipping with peptide-conjugated morpholinos in the heart of a dog model of Duchenne muscular dystrophy

A. Nakamura, P. Iversen, R. Kole, 2017, Proceedings of the National Academy of Sciences.

Inhibition of norovirus replication by morpholino oligomers targeting the 5′-end of the genome

P. Iversen, K. Bok, A. Campbell, 2008, Virology.

Eastern equine encephalitis virus rapidly infects and disseminates in the brain and spinal cord of cynomolgus macaques following aerosol challenge

P. Iversen, S. Bavari, F. Nasar, 2022, PLoS neglected tropical diseases.

Binding of antisense phosphorothioate oligonucleotides to murine lymphocytes is lineage specific and inducible.

P. Iversen, G. Zon, D. Crouse, 1992, Antisense research and development.

Cationic phosphorodiamidate morpholino oligomers efficiently prevent growth of Escherichia coli in vitro and in vivo.

P. Iversen, D. Weller, B. Geller, 2010, The Journal of antimicrobial chemotherapy.

Variations in Amino Acid Composition of Antisense Peptide-Phosphorodiamidate Morpholino Oligomer Affect Potency against Escherichia coli In Vitro and In Vivo

P. Iversen, Lucas D. Tilley, B. Geller, 2008, Antimicrobial Agents and Chemotherapy.

Prenatal and presymptomatic diagnosis of the marfan syndrome using fluorescence pcr and an automated sequencer

P. Iversen, C. Price, M. Godfrey, 1995, Prenatal Diagnosis.

Antisense phosphorodiamidate morpholino oligomers targeted to an essential gene inhibit Burkholderia cepacia complex.

S. Holland, P. Iversen, D. Greenberg, 2010, The Journal of infectious diseases.

Pharmacokinetics and biodistribution of phosphorodiamidate morpholino antisense oligomers.

P. Iversen, A. Amantana, 2005, Current opinion in pharmacology.

Inhibition of the rat cytochrome P450 3A2 by an antisense phosphorothioate oligodeoxynucleotide in vivo.

P. Iversen, J. Desjardins, 1995, The Journal of pharmacology and experimental therapeutics.

A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus

D. A. Stein, J. Stone, R. Andino, 2008, Antimicrobial Agents and Chemotherapy.

Detection of vesicular exanthema of swine-like calicivirus in tissues from a naturally infected spontaneously aborted bovine fetus.

D. A. Stein, P. Iversen, T. Berke, 2002, Journal of the American Veterinary Medical Association.

Vesivirus viremia and seroprevalence in humans

D. A. Stein, P. Iversen, K. Bok, 2006, Journal of medical virology.

Isolation and characterization of a new Vesivirus from rabbits.

P. Iversen, D. Matson, D. Skilling, 2005, Virology.

The development of broad-spectrum antiviral medical countermeasures to treat viral hemorrhagic fevers caused by natural or weaponized virus infections

P. Iversen, M. Hickman, Christopher D Kane, 2022, PLoS neglected tropical diseases.

Monoclonal antibodies to two epitopes of beta-human chorionic gonadotropin for the treatment of cancer.

P. Iversen, H. Moulton, D. Mourich, 2003, Current opinion in molecular therapeutics.

Inhibition of human chorionic gonadotropin β‐subunit modulates the mitogenic effect of c‐myc in human prostate cancer cells

P. Iversen, G. Devi, C. A. London, 2002, The Prostate.

Characterization of a variety of standard collagen substrates: Ultrastructure, uniformity, and capacity to bind and promote growth of neurons

L. M. Partlow, L. Stensaas, F. Moatamed, 1981, In Vitro.

Bacterial Infectious Disease Threat

P. Iversen, 2018 .

Inhibition, Escape, and Attenuated Growth of Severe Acute Respiratory Syndrome Coronavirus Treated with Antisense Morpholino Oligomers

Peter Kuhn, David A. Stein, D. A. Stein, 2005, Journal of Virology.

Inhibition of human immunodeficiency virus type 1-mediated cytopathic effects by poly(L-lysine)-conjugated synthetic antisense oligodeoxyribonucleotides.

P. Iversen, M. Stevenson, 1989, The Journal of general virology.

A Morpholino Oligomer Targeting Highly Conserved Internal Ribosome Entry Site Sequence Is Able To Inhibit Multiple Species of Picornavirus

D. A. Stein, J. Stone, R. Andino, 2008, Antimicrobial Agents and Chemotherapy.

Inhibition of respiratory syncytial virus infections with morpholino oligomers in cell cultures and in mice.

D. A. Stein, T. Ivanciuc, P. Iversen, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Intracellular delivery strategies for antisense phosphorodiamidate morpholino oligomers.

P. Iversen, C. Ghosh, 2000, Antisense & nucleic acid drug development.

c-Myc antisense limits rat liver regeneration and indicates role for c-Myc in regulating cytochrome P-450 3A activity.

D. A. Stein, P. Iversen, M. T. Reddy, 2000, The Journal of pharmacology and experimental therapeutics.

Continuous infusion of antisense phosphorothioate therapeutics.

P. Iversen, M. Bishop, B. Copple, 1996, Methods in molecular medicine.

Bolus intravenous injection of phosphorothioate oligonucleotides causes hypotension by acting as alpha(1)-adrenergic receptor antagonists.

P. Iversen, D. Bylund, J. Mata, 1999, Toxicology and Applied Pharmacology.

Antisense oligonucleotide-induced exon skipping restores dystrophin expression in vitro in a canine model of DMD

P. Iversen, H. Moulton, S. Wilton, 2006, Gene Therapy.

Transdermal delivery of antisense oligonucleotides can induce changes in gene expression in vivo.

P. Iversen, R. Brand, T. L. Hannah, 2001, Antisense & nucleic acid drug development.

Inhibition of Flavivirus Infections by Antisense Oligomers Specifically Suppressing Viral Translation and RNA Replication

D. A. Stein, L. Kramer, P. Iversen, 2005, Journal of Virology.

Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus

D. A. Stein, P. Iversen, Yanjin Zhang, 2008, Molecular Cancer Therapeutics.

Expression and regulation of brain metallothionein

P. Iversen, H. Happe, D. R. Cerutis, 1995, Neurochemistry International.

Alternative Splicing in the Nuclear Receptor Superfamily Expands Gene Function to Refine Endo-Xenobiotic Metabolism

P. Iversen, A. Annalora, C. Marcus, 2020, Drug Metabolism and Disposition.

Alternative Splicing in the Nuclear Receptor Superfamily Expands Gene Function to Refine Endo-Xenobiotic Metabolism

P. Iversen, A. Annalora, C. Marcus, 2020, Drug Metabolism and Disposition.

Alternative splicing of the vitamin D receptor modulates target gene expression and promotes ligand‐independent functions

P. Iversen, A. Annalora, C. Marcus, 2019, Toxicology and applied pharmacology.

Down-regulation of SNAIL suppresses MIN mouse tumorigenesis: modulation of apoptosis, proliferation, and fractal dimension.

Vadim Backman, Young L. Kim, Young Kim, 2004, Molecular cancer therapeutics.

AVI-7288 for Marburg Virus in Nonhuman Primates and Humans.

P. Iversen, D. Swenson, S. Bavari, 2015, New England Journal of Medicine.

Gene-silencing antisense oligomers inhibit acinetobacter growth in vitro and in vivo.

David E Greenberg, P. Iversen, D. Greenberg, 2013, The Journal of infectious diseases.

Inhibition of influenza A H3N8 virus infections in mice by morpholino oligomers

D. A. Stein, P. Iversen, Christopher R. Lupfer, 2008, Archives of Virology.

Antisense oligonucleotide development for the selective modulation of CYP3A5 in renal disease

P. Iversen, J. Himmelfarb, A. Annalora, 2021, Scientific Reports.

Gene structure and nucleotide sequence for rat cytochrome P-450c.

P. Iversen, E. Bresnick, R. Hines, 1985, Archives of biochemistry and biophysics.

West Nile virus genome cyclization and RNA replication require two pairs of long-distance RNA interactions.

D. A. Stein, P. Iversen, P. Shi, 2008, Virology.

Inhibition of Cytochrome P450 and Multidrug Resistance Proteins Potentiates the Efficacy of All-Trans Retinoic Acid in Pancreatic Cancer In Vitro and In Vivo

P. Iversen, T. Adrian, T. El-Abaseri, 2015 .

Reduced Expression of CD45 Protein-tyrosine Phosphatase Provides Protection against Anthrax Pathogenesis*

Steven B. Bradfute, G. Ruthel, P. Iversen, 2009, Journal of Biological Chemistry.

A Single Phosphorodiamidate Morpholino Oligomer Targeting VP24 Protects Rhesus Monkeys against Lethal Ebola Virus Infection

P. Iversen, S. Bavari, S. Reid, 2015, mBio.

VP35 Knockdown Inhibits Ebola Virus Amplification and Protects against Lethal Infection in Mice

D. A. Stein, P. Iversen, D. Swenson, 2006, Antimicrobial Agents and Chemotherapy.

Delayed Time-to-Treatment of an Antisense Morpholino Oligomer Is Effective against Lethal Marburg Virus Infection in Cynomolgus Macaques

G. Palacios, P. Iversen, S. Bavari, 2016, PLoS neglected tropical diseases.

Advanced antisense therapies for postexposure protection against lethal filovirus infections

P. Iversen, D. Swenson, S. Bavari, 2010, Nature Medicine.

Recent successes in therapeutics for Ebola virus disease: no time for complacency

Jeffrey R. Kugelman, Chih-yuan Chiang, J. Kuhn, 2020, The Lancet Infectious Diseases.

Remdesivir is efficacious in rhesus monkeys exposed to aerosolized Ebola virus

P. Iversen, S. Bavari, T. Cihlar, 2021, Scientific Reports.

Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors

J. Kuhn, G. Palacios, P. Iversen, 2022, Science Translational Medicine.

Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies

P. Iversen, P. Sazani, E. Kaye, 2014, Antimicrobial Agents and Chemotherapy.

Viral diversity and clonal evolution from unphased genomic data

Jeffrey R. Kugelman, R. Rabadán, Joseph Chan, 2014, BMC Genomics.

Arginine‐rich cell penetrating peptides: Design, structure–activity, and applications to alter pre‐mRNA splicing by steric‐block oligonucleotides

P. Iversen, H. Moulton, B. Lebleu, 2008, Journal of peptide science : an official publication of the European Peptide Society.

Cell penetrating peptide conjugates of steric block oligonucleotides☆

D. A. Stein, P. Iversen, H. Moulton, 2007, Advanced Drug Delivery Reviews.

Selective cytotoxicity to human leukemic myeloblasts produced by oligodeoxyribonucleotide phosphorothioates complementary to p53 nucleotide sequences.

P. Iversen, R. Ruddon, E. Bayever, 1994, Leukemia & lymphoma.

Transient Inhibition of Endogenous Transforming Growth Factor-β1 (Tgfβ1) in Hematopoietic Stem Cells Accelerates Engraftment and Enhances Multi-Lineage Repopulating Efficiency

P. Iversen, F. Ruscetti, S. Bartelmez, 2016 .

A k-mer based transcriptomics approach for antisense drug discovery targeting the Ewing’s family of tumors

P. Iversen, J. Summerton, A. Annalora, 2018, Oncotarget.

Inhibition of Intracellular Growth of Salmonella enterica Serovar Typhimurium in Tissue Culture by Antisense Peptide-Phosphorodiamidate Morpholino Oligomer

P. Iversen, B. Geller, Brett L. Mellbye, 2009, Antimicrobial Agents and Chemotherapy.

Regulation of zinc metallothionein II mRNA level in rat brain

P. Iversen, M. Ebadi, V. Paliwal, 1990, Neurochemistry International.

Antisense therapy for restenosis following percutaneous coronary intervention

N. Kipshidze, M. Tsapenko, P. Iversen, 2005, Expert opinion on biological therapy.

A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity

D. A. Stein, P. Iversen, H. Sekhon, 2003, Cancer Gene Therapy.

lontophoretic Delivery of a Telomeric Oligonucleotide

P. Iversen, R. Brand, 1996, Pharmaceutical Research.

Effects of size and sequence on the iontophoretic delivery of oligonucleotides.

P. Iversen, A. Wahl, R. Brand, 1998, Journal of pharmaceutical sciences.

Phosphorodiamidate morpholino oligomers: favorable properties for sequence-specific gene inactivation.

P. Iversen, 2001, Current opinion in molecular therapeutics.

Anin vitro model for endothelial permeability: Assessment of monolayer integrity

P. Iversen, M. Cano, Peter W. Kazakoff, 1995, In Vitro Cellular & Developmental Biology - Animal.

Inhibition of measles virus infections in cell cultures by peptide-conjugated morpholino oligomers.

Michael J Reddish, D. A. Stein, P. Iversen, 2009, Virus research.

Inhibition of Multiple Subtypes of Influenza A Virus in Cell Cultures with Morpholino Oligomers

D. A. Stein, Jianzhu Chen, P. Iversen, 2006, Antimicrobial Agents and Chemotherapy.

Chemicals in the Environment

P. Iversen, 2018 .

Antiproliferative effects of steric blocking phosphorodiamidate morpholino antisense agents directed against c-myc.

P. Iversen, J. Summerton, D. Weller, 2000, Antisense & nucleic acid drug development.

The molecular biology of the polycyclic aromatic hydrocarbon inducible cytochrome P‐450; the past is prologue

P. Iversen, E. Bresnick, R. Hines, 1986, BioEssays : news and reviews in molecular, cellular and developmental biology.

Antiviral activity of morpholino oligomers designed to block various aspects of Equine arteritis virus amplification in cell culture.

D. A. Stein, P. Iversen, E. Snijder, 2005, The Journal of general virology.

Peptide conjugated phosphorodiamidate morpholino oligomers increase survival of mice challenged with Ames Bacillus anthracis.

P. Iversen, S. Bavari, R. Panchal, 2012, Nucleic acid therapeutics.

Chemical Modifications of Antisense Morpholino Oligomers Enhance Their Efficacy against Ebola Virus Infection

G. Ruthel, P. Iversen, H. Moulton, 2009, Antimicrobial Agents and Chemotherapy.

Transdermal delivery of antisense oligonucleotides.

P. Iversen, R. Brand, 2005, Methods in molecular medicine.

Transdermal Use of Phosphorodiamidate Morpholino Oligomer AVI-4472 Inhibits Cytochrome P450 3A2 Activity in Male Rats

P. Iversen, R. Brand, V. Arora, 2002, Pharmaceutical Research.

Phosphorodiamidate morpholino antisense oligomers inhibit expression of human cytochrome P450 3A4 and alter selected drug metabolism.

P. Iversen, Melissa L Cate, C. Ghosh, 2002, Drug metabolism and disposition: the biological fate of chemicals.

Systemic human antisense therapy begins.

P. Iversen, G. Zon, E. Bayever, 1992, Antisense research and development.

Targeted vascular delivery of antisense molecules using intravenous microbubbles.

N. Kipshidze, P. Iversen, S. Maiti, 2006, Cardiovascular revascularization medicine : including molecular interventions.

Arginine-rich cell-penetrating peptides facilitate delivery of antisense oligomers into murine leukocytes and alter pre-mRNA splicing.

P. Iversen, N. Kerkvliet, H. Moulton, 2007, Journal of immunological methods.

The suppression of metallothionein synthesis inhibits the growth of leukemia P388 cells

P. Iversen, S. Okada, A. Takeda, 1999 .

Active Oxygen Defenses

P. Iversen, 2018 .

Antisense phosphorodiamidate morpholino oligomer inhibits viability of Escherichia coli in pure culture and in mouse peritonitis.

P. Iversen, Lucas D. Tilley, B. Geller, 2005, The Journal of antimicrobial chemotherapy.

Reduction in tamoxifen‐induced CYP3A2 expression and DNA adducts using antisense technology

P. Iversen, B. Mahadevan, W. Baird, 2006, Molecular carcinogenesis.

Inhibition of Dengue Virus Serotypes 1 to 4 in Vero Cell Cultures with Morpholino Oligomers

D. A. Stein, C. Huang, P. Iversen, 2005, Journal of Virology.

Splicing in the immune system: potential targets for therapeutic intervention by antisense-mediated alternative splicing.

P. Iversen, D. Mourich, 2009, Current opinion in molecular therapeutics.

In vivo growth inhibition of leukemia P388 by Metallothionein‐I antisense oligodeoxyribonucleotide

P. Iversen, S. Okada, A. Takeda, 1998 .

Preparation and partial characterization of highly purified primary cultures of neurons and non-neuronal (glial) cells from embryonic chick cerebral hemispheres and several other regions of the nervous system.

L. M. Partlow, P. Iversen, G. Hanson, 1982, Brain research.

Increased suppression of intracoronary C-myc protein synthesis within the stent or balloon injury site using an intravenous microbubble delivery system containing antisense to C-myc: Comparison with direct intracoronary injection

P. Iversen, T. Porter, F. Xie, 2003 .

Photoactivation of Vascular iNOS and Elevation of cGMP In Vivo: Possible Mechanism for Photovasorelaxation and Inhibition of Restenosis in an Atherosclerotic Rabbit Model¶

N. Kipshidze, J. Moses, M. Leon, 2000 .

Stability of cell-penetrating peptide-morpholino oligomer conjugates in human serum and in cells.

P. Iversen, H. Moulton, Jed N. Hassinger, 2007, Bioconjugate chemistry.

Treatment of AG129 mice with antisense morpholino oligomers increases survival time following challenge with dengue 2 virus

D. A. Stein, C. Huang, P. Iversen, 2008, The Journal of antimicrobial chemotherapy.

Cell-penetrating peptides as transporters for morpholino oligomers: effects of amino acid composition on intracellular delivery and cytotoxicity

P. Iversen, H. Moulton, Jed N. Hassinger, 2007, Nucleic acids research.

Bacterial Resistance to Antisense Peptide Phosphorodiamidate Morpholino Oligomers

Michael Freitag, Bruce L. Geller, P. Iversen, 2012, Antimicrobial Agents and Chemotherapy.

Functional Activation of Autologous Human Diabetic Stem Cells for Cell Therapy

P. Iversen, Patrick L. Iversen, Francis W. Ruscetti, 2018, In Vivo and Ex Vivo Gene Therapy for Inherited and Non-Inherited Disorders.

Involvement of vacuolar protein sorting pathway in Ebola virus release independent of TSG101 interaction.

G. Ruthel, P. Iversen, M. Aman, 2007, The Journal of infectious diseases.

First human experience with local delivery of novel antisense AVI-4126 with Infiltrator catheter in de novo native and restenotic coronary arteries: 6-month clinical and angiographic follow-up from AVAIL study.

N. Kipshidze, J. Moses, M. Leon, 2007, Cardiovascular revascularization medicine : including molecular interventions.

Arginine-rich peptide conjugation to morpholino oligomers: effects on antisense activity and specificity.

D. A. Stein, P. Iversen, H. Moulton, 2005, Bioconjugate chemistry.

Transdermal delivery of antisense compounds.

P. Iversen, R. Brand, 2000, Advanced drug delivery reviews.

Evidence of Enhanced Iron Excretion During Systemic Phosphorothioate Oligodeoxynucleotide Treatment

P. Iversen, M. Bishop, J. Mata, 2000, Journal of toxicology. Clinical toxicology.

Neuronal stimulation of non-neuronal (glial) cell proliferation: lack of specificity between different regions of the nervous system.

L. M. Partlow, P. Iversen, G. Hanson, 1982, Brain research.

Systemic targeted delivery of antisense with perflourobutane gas microbubble carrier reduced neointimal formation in the porcine coronary restenosis model.

N. Kipshidze, G. Dangas, J. Moses, 2003, Cardiovascular radiation medicine.

Peptide-based delivery of nucleic acids: design, mechanism of uptake and applications to splice-correcting oligonucleotides.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

Antisense oligonucleotide-mediated inhibition of metallothionein protein synthesis in neuroblastoma IMR 32 and Chang liver cells in culture.

P. Iversen, M. Ebadi, 1992, Biological signals.

Antisense peptide-phosphorodiamidate morpholino oligomer conjugate: dose-response in mice infected with Escherichia coli.

P. Iversen, Lucas D. Tilley, B. Geller, 2006, The Journal of antimicrobial chemotherapy.

Efficacy of antisense morpholino oligomer targeted to c-myc in prostate cancer xenograft murine model and a Phase I safety study in humans.

P. Iversen, G. Devi, D. Mason, 2003, Clinical cancer research : an official journal of the American Association for Cancer Research.

Experimental Therapeutics: Antisense and Gene Therapy Cardiovascular Drugs

P. Iversen, 2014 .

Cell-penetrating-peptide-based delivery of oligonucleotides: an overview.

P. Iversen, H. Moulton, B. Lebleu, 2007, Biochemical Society transactions.

A novel therapeutic vaccine targeting the soluble TNFα receptor II to limit the progression of cardiovascular disease: AtheroVax™

N. Kipshidze, G. Dangas, P. Iversen, 2023, Frontiers in cardiovascular medicine.

Induction of revertant fibres in the mdx mouse using antisense oligonucleotides

P. Iversen, S. Wilton, R. Johnsen, 2006, Genetic vaccines and therapy.

P. Iversen, 2018, Molecular Basis of Resilience.

In Vitro Resistance Selection and In Vivo Efficacy of Morpholino Oligomers against West Nile Virus

Susan A. Jones, C. J. Bennett, D. A. Stein, 2007, Antimicrobial Agents and Chemotherapy.

Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections.

P. Iversen, B. Sproat, J. Ludwig, 1996, The Journal of pharmacology and experimental therapeutics.

Reaction between metabolically activated acetaminophen and phosphorothioate oligonucleotides.

P. Iversen, B. Copple, W. Gmeiner, 1995, Toxicology and Applied Pharmacology.

Suppression of Philadelphia leukema cell growth in mice by bcr-abl antisense oligodeoxynucleotides

P. Iversen, G. Zon, B. Calabretta, 1993 .

Novel site‐specific systemic delivery of Rapamycin with perfluorobutane gas microbubble carrier reduced neointimal formation in a porcine coronary restenosis model

Antonio Colombo, George Dangas, Ron Waksman, 2005, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Advanced c‐myc antisense (AVI‐4126)‐eluting phosphorylcholine‐coated stent implantation is associated with complete vascular healing and reduced neointimal formation in the porcine coronary restenosis model

G. Stone, N. Kipshidze, G. Dangas, 2004, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Induction of cytochromes P450IA1 and P450IA2 as determined by solution hybridization.

P. Iversen, E. Bresnick, P. Raval, 1991, Biochemical pharmacology.

Antisense oligonucleotides targeted to the p53 gene modulate liver regeneration in vivo.

P. Iversen, V. Arora, Patrick L. Iversen, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Oligomers Phosphorodiamidate Morpholino Bacterial Resistance to Antisense Peptide

P. Iversen, Lucas D. Tilley, Kyle R. Pomraning, 2012 .

Safety, tolerability, and pharmacokinetics of radavirsen (AVI‐7100), an antisense oligonucleotide targeting influenza a M1/M2 translation

R. Davey, P. Iversen, J. Beigel, 2018, British journal of clinical pharmacology.

Alternative Splicing in the Nuclear Receptor Superfamily Redirects Human Metabolic Homeostasis

P. Iversen, A. Annalora, C. Marcus, 2020 .

Induced IL-10 splice altering approach to antiviral drug discovery.

Steven B. Bradfute, P. Iversen, S. Bavari, 2014, Nucleic acid therapeutics.

Sustained dystrophin expression induced by peptide-conjugated morpholino oligomers in the muscles of mdx mice.

P. Iversen, R. Kole, H. Moulton, 2008, Molecular therapy : the journal of the American Society of Gene Therapy.

Bacterial Resistance to Antisense Peptide Phosphorodiamidate Morpholino Oligomers

P. Iversen, M. Freitag, Lucas D. Tilley, 2012, Antimicrobial Agents and Chemotherapy.

Cellular uptake of neutral phosphorodiamidate morpholino oligomers.

P. Iversen, K. Aird, G. Devi, 2009, Current Pharmaceutical Biotechnology.

Safety and Pharmacokinetic Profiles of Phosphorodiamidate Morpholino Oligomers with Activity against Ebola Virus and Marburg Virus: Results of Two Single-Ascending-Dose Studies

P. Iversen, P. Sazani, E. Kaye, 2014, Antimicrobial Agents and Chemotherapy.

Blockade of viral interleukin-6 expression of Kaposi's sarcoma–associated herpesvirus

D. A. Stein, P. Iversen, Yanjin Zhang, 2008, Molecular Cancer Therapeutics.