J. Kemper

发表

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*

T. Veenstra, Bhaskar Ponugoti, Dong-Hyun Kim, 2010, The Journal of Biological Chemistry.

A postprandial FGF19‐SHP‐LSD1 regulatory axis mediates epigenetic repression of hepatic autophagy

J. Kemper, Yang Zhang, Jian Ma, 2017, The EMBO journal.

Transcriptional regulation of autophagy by an FXR/CREB axis

G. Yoon, Yang Li, Wenxuan Zhong, 2014, Nature.

Guidelines for the use and interpretation of assays formonitoring autophagy (3rd edition)

Sangeeta Khare, Xin Qi, Ying Wang, 2016 .

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Dong-Hyun Kim, J. Kemper, H. Xu, 2018, Nature Communications.

Differential regulation of rat and human CYP7A1 by the nuclear oxysterol receptor liver X receptor-alpha.

S. Kliewer, Ji Miao, J. Kemper, 2003, Molecular endocrinology.

MicroRNA 34a Inhibits Beige and Brown Fat Formation in Obesity in Part by Suppressing Adipocyte Fibroblast Growth Factor 21 Signaling and SIRT1 Function

J. Kemper, H. Xu, Sung-E. Choi, 2014, Molecular and Cellular Biology.

Brd4 modulates diet-induced obesity via PPARγ-dependent Gdf3 expression in adipose tissue macrophages

Dong-Hyun Kim, J. Kemper, Lin-Feng Chen, 2021, JCI insight.

SHP Repression of Bile Acid Biosynthesis by Remodeling Complex in the Feedback Role of an mSin 3 A-Swi / Snf Chromatin

Ji Miao, J. Kemper, Hwajin Kim, 2004 .

Repression of CAR-mediated transactivation of CYP2B genes by the orphan nuclear receptor, short heterodimer partner (SHP).

J. Kemper, B. Kemper, Yangjin Bae, 2004, DNA and cell biology.

Glucocorticoid Receptor-interacting Protein 1 Mediates Ligand-independent Nuclear Translocation and Activation of Constitutive Androstane Receptor in Vivo *

J. Kemper, B. Kemper, G. Min, 2002, The Journal of Biological Chemistry.

Feeding activates FGF15‐SHP‐TFEB‐mediated lipophagy in the gut

J. Kemper, Yang Zhang, Jian Ma, 2022, The EMBO journal.

Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2

Jian Ma, J. Kemper, Yang Zhang, 2015, Genome Biology.

Arginine Methylation by PRMT5 at a Naturally Occurring Mutation Site Is Critical for Liver Metabolic Regulation by Small Heterodimer Partner

T. Veenstra, Dong-Hyun Kim, Zhen Xiao, 2011, Molecular and Cellular Biology.

Ligand-dependent regulation of the activity of the orphan nuclear receptor, small heterodimer partner (SHP), in the repression of bile acid biosynthetic CYP7A1 and CYP8B1 genes.

T. Willson, Linda Yang, W. Zuercher, 2011, Molecular endocrinology.

Functional Specificities of Brm and Brg-1 Swi/Snf ATPases in the Feedback Regulation of Hepatic Bile Acid Biosynthesis

Ji Miao, J. Kemper, K. Knudsen, 2009, Molecular and Cellular Biology.

Small Heterodimer Partner and Fibroblast Growth Factor 19 Inhibit Expression of NPC1L1 in Mouse Intestine and Cholesterol Absorption.

J. Kemper, H. Xu, B. Kemper, 2019, Gastroenterology.

FXR Primes the Liver for Intestinal FGF15 Signaling by Transient Induction of β-Klotho.

Dong-Hyun Kim, J. Kemper, H. Xu, 2016, Molecular endocrinology.

Mitochondrial protease ClpP supplementation ameliorates diet-induced NASH in mice.

T. Shin, J. Kemper, H. Song, 2022, Journal of hepatology.

Defective FXR-SHP Regulation in Obesity Aberrantly Increases miR-802 Expression, Promoting Insulin Resistance and Fatty Liver

J. Kemper, B. Kemper, Young-Chae Kim, 2020, Diabetes.

Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1

Mark R. Marten, Erinna F. Lee, Dana L. Miller, 2021, Autophagy.

BRD4 inhibition and FXR activation, individually beneficial in cholestasis, are antagonistic in combination.

Shwu‐Yuan Wu, C. Chiang, J. Kemper, 2020, JCI insight.

Cross-Regulation of Protein Stability by p53 and Nuclear Receptor SHP

J. Kemper, Zhihong Yang, Yuxia Zhang, 2012, PloS one.

Obesity-induced miR-802 directly targets AMPK and promotes nonalcoholic steatohepatitis in mice

J. Kemper, B. Kemper, Sunmi Seok, 2022, Molecular metabolism.

Epigenomic regulation of bile acid metabolism: Emerging role of transcriptional cofactors

Zachary Smith, J. Kemper, D. Ryerson, 2013, Molecular and Cellular Endocrinology.

Ligand-activated Pregnane X Receptor Interferes with HNF-4 Signaling by Targeting a Common Coactivator PGC-1α

J. Kemper, S. Bhalla, S. Fang, 2004, Journal of Biological Chemistry.

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Laura G. Dubois, J. Kemper, J. Thompson, 2017, Nature Communications.

Intestinal FGF15/19 physiologically repress hepatic lipogenesis in the late fed-state by activating SHP and DNMT3A

J. Kemper, Yang Zhang, Jian Ma, 2020, Nature Communications.

FXR acetylation is normally dynamically regulated by p300 and SIRT1 but constitutively elevated in metabolic disease states.

T. Veenstra, Bhaskar Ponugoti, Zhen Xiao, 2009, Cell metabolism.

The cholesterol metabolite 27 hydroxycholesterol facilitates breast cancer metastasis through its actions on immune cells

Laura G. Dubois, J. Kemper, J. Thompson, 2017, Nature Communications.

A Pathway Involving Farnesoid X Receptor and Small Heterodimer Partner Positively Regulates Hepatic Sirtuin 1 Levels via MicroRNA-34a Inhibition*

Y. Mo, Ji Miao, J. Kemper, 2010, The Journal of Biological Chemistry.

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

J. Kemper, Yang Zhang, Jian Ma, 2020, Nature Communications.

Postprandial FGF19-induced phosphorylation by Src is critical for FXR function in bile acid homeostasis

Dong-Hyun Kim, J. Kemper, H. Xu, 2018, Nature Communications.

Inhibitory Cross-talk between Estrogen Receptor (ER) and Constitutively Activated Androstane Receptor (CAR)

J. Kemper, L. N. Petz, Hwajin Kim, 2002, The Journal of Biological Chemistry.

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

J. Kemper, Yang Zhang, Jian Ma, 2018, Nature Communications.

Functional interaction of hepatic nuclear factor-4 and peroxisome proliferator-activated receptor-gamma coactivator 1alpha in CYP7A1 regulation is inhibited by a key lipogenic activator, sterol regulatory element-binding protein-1c.

Bhaskar Ponugoti, J. Kemper, Sungsoon Fang, 2007, Molecular endocrinology.

Small Heterodimer Partner Regulates Dichotomous T Cell Expansion by Macrophages.

J. Kemper, E. Nelson, Young-Chae Kim, 2019, Endocrinology.

Functional Inhibitory Cross-talk between Constitutive Androstane Receptor and Hepatic Nuclear Factor-4 in Hepatic Lipid/Glucose Metabolism Is Mediated by Competition for Binding to the DR1 Motif and to the Common Coactivators, GRIP-1 and PGC-1α*

Ji Miao, J. Kemper, Yangjin Bae, 2006, Journal of Biological Chemistry.

Differential regulation of the human progesterone receptor gene through an estrogen response element half site and Sp1 sites

J. Kemper, A. Nardulli, L. N. Petz, 2004, The Journal of Steroid Biochemistry and Molecular Biology.

Liver ChIP-seq analysis in FGF19-treated mice reveals SHP as a global transcriptional partner of SREBP-2

J. Kemper, Yang Zhang, Jian Ma, 2015, Genome Biology.

Brd4 links chromatin targeting to HPV transcriptional silencing.

Shwu‐Yuan Wu, C. Chiang, J. Kemper, 2006, Genes & development.

Regulation of FXR transcriptional activity in health and disease: Emerging roles of FXR cofactors and post-translational modifications.

J. Kemper, 2011, Biochimica et biophysica acta.

Elevated microRNA‐34a in obesity reduces NAD+ levels and SIRT1 activity by directly targeting NAMPT

Xiaoling Li, Dong-Hyun Kim, J. Kemper, 2013, Aging cell.

Acid Metabolism SHP-Mediated Regulation of Hepatic Bile Chromatin-Modifying Enzymes in Methyltransferase G 9 a and Other Coordinated Recruitment of Histone

Bhaskar Ponugoti, Ji Miao, J. Kemper, 2007 .

Coordinated Recruitment of Histone Methyltransferase G9a and Other Chromatin-Modifying Enzymes in SHP-Mediated Regulation of Hepatic Bile Acid Metabolism

Bhaskar Ponugoti, Ji Miao, J. Kemper, 2006, Molecular and Cellular Biology.

Sirtuin 1 deacetylase: a key regulator of hepatic lipid metabolism.

J. Kemper, Dong Hyun Kim, Sung-E. Choi, 2013, Vitamins and hormones.

Aberrantly elevated microRNA-34a in obesity attenuates hepatic responses to FGF19 by targeting a membrane coreceptor β-Klotho

Dong-Hyun Kim, J. Kemper, H. Xu, 2012, Proceedings of the National Academy of Sciences.

Hepatic Deletion of SIRT1 Decreases Hepatocyte Nuclear Factor 1α/Farnesoid X Receptor Signaling and Induces Formation of Cholesterol Gallstones in Mice

Qing Xu, Xiaoling Li, A. Purushotham, 2012, Molecular and Cellular Biology.

Regulation of SIRT1 by MicroRNAs

J. Kemper, Sung-E. Choi, Sung-E Choi, 2013, Molecules and cells.

Analysis of multiple nuclear receptor binding sites for CAR/RXR in the phenobarbital responsive unit of CYP2B2.

J. Kemper, B. Kemper, Yangjin Bae, 2006, Archives of biochemistry and biophysics.

AhR and SHP regulate phosphatidylcholine and S-adenosylmethionine levels in the one-carbon cycle

J. Kemper, Yang Zhang, Jian Ma, 2018, Nature Communications.

MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity.

J. Kemper, T. Fu, 2016, Vitamins and hormones.

Phosphorylation of hepatic farnesoid X receptor by FGF19 signaling–activated Src maintains cholesterol levels and protects from atherosclerosis

Dong-Hyun Kim, J. Kemper, B. Kemper, 2019, The Journal of Biological Chemistry.

Controlling SIRT1 expression by microRNAs in health and metabolic disease

J. Kemper, Jiyoung Lee, 2010, Aging.

Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation.

Timothy D Veenstra, T. Veenstra, Zhen Xiao, 2009, Genes & development.

Fasting-induced FGF21 signaling activates hepatic autophagy and lipid degradation via JMJD3 histone demethylase

J. Kemper, Yang Zhang, Jian Ma, 2020, Nature Communications.

Fasting‐induced JMJD3 histone demethylase epigenetically activates mitochondrial fatty acid &bgr;‐oxidation

Zhen Xiao, J. Kemper, Yang Zhang, 2018, The Journal of clinical investigation.

Obesity and aging diminish sirtuin 1 (SIRT1)-mediated deacetylation of SIRT3, leading to hyperacetylation and decreased activity and stability of SIRT3

Xiaoling Li, J. Kemper, B. Kemper, 2017, The Journal of Biological Chemistry.

Genomic analysis of hepatic farnesoid X receptor binding sites reveals altered binding in obesity and direct gene repression by farnesoid X receptor in mice

Zachary Smith, J. Kemper, P. Yu, 2012, Hepatology.

The p300 Acetylase Is Critical for Ligand-activated Farnesoid X Receptor (FXR) Induction of SHP*

T. Willson, Bhaskar Ponugoti, Shwu‐Yuan Wu, 2008, Journal of Biological Chemistry.

Critical role of RanBP2-mediated SUMOylation of Small Heterodimer Partner in maintaining bile acid homeostasis

Dong-Hyun Kim, Zhen Xiao, Shwu‐Yuan Wu, 2016, Nature Communications.

Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356

Sara W. Bird, Erinna F. Lee, Michael D. Kim, 2016 .

Role of an mSin3A-Swi/Snf Chromatin Remodeling Complex in the Feedback Repression of Bile Acid Biosynthesis by SHP

Ji Miao, J. Kemper, Hwajin Kim, 2004, Molecular and Cellular Biology.

A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity

Dong-Hyun Kim, Zhen Xiao, Shwu‐Yuan Wu, 2015, The EMBO journal.

MicroRNA‐210 Promotes Bile Acid–Induced Cholestatic Liver Injury by Targeting Mixed‐Lineage Leukemia‐4 Methyltransferase in Mice

J. Kemper, Yang Zhang, Jian Ma, 2020, Hepatology.

Obesity-Linked Phosphorylation of SIRT1 by Casein Kinase 2 Inhibits Its Nuclear Localization and Promotes Fatty Liver

Xiaoling Li, Zhen Xiao, J. Kemper, 2017, Molecular and Cellular Biology.

Transgenic mice lacking FGF15/19-SHP phosphorylation display altered bile acids and gut bacteria, promoting nonalcoholic fatty liver disease

J. Kemper, M. Qi, B. Kemper, 2023, The Journal of biological chemistry.

Bile Acid Signal-induced Phosphorylation of Small Heterodimer Partner by Protein Kinase Cζ Is Critical for Epigenomic Regulation of Liver Metabolic Genes*

T. Veenstra, Zhen Xiao, J. Kemper, 2013, The Journal of Biological Chemistry.

Farnesoid X receptor–induced lysine‐specific histone demethylase reduces hepatic bile acid levels and protects the liver against bile acid toxicity

J. Kemper, B. Kemper, S. Byun, 2015, Hepatology.

Hepatic Phospholipid Remodeling Modulates Insulin Sensitivity and Systemic Metabolism

J. Kemper, R. Friedline, D. Ford, 2023, Advanced science.

MicroRNA regulation of AMPK in nonalcoholic fatty liver disease

J. Kemper, Hao Sun, 2023, Experimental & molecular medicine.

SIRT1 Deacetylates and Inhibits SREBP-1C Activity in Regulation of Hepatic Lipid Metabolism*

T. Veenstra, Bhaskar Ponugoti, Dong-Hyun Kim, 2010, The Journal of Biological Chemistry.

MicroRNA-34a and Impaired FGF19/21 Signaling in Obesity.

J. Kemper, T. Fu, 2016, Vitamins and hormones.

Inhibitory protein–protein interactions of the SIRT1 deacetylase are choreographed by post‐translational modification

Troy C. Krzysiak, J. Kemper, Laurel Thomas, 2024, Protein science : a publication of the Protein Society.

Membrane phospholipid remodeling modulates nonalcoholic steatohepatitis progression by regulating mitochondrial homeostasis

J. Kemper, D. Ford, Kai Zhang, 2023, Hepatology.