D. Link

D. Link, M. Christopher, Matthew J. Christopher, 2008, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

A role for G-CSF receptor signaling in the regulation of hematopoietic cell function but not lineage commitment or differentiation.

D. Link, Fulu Liu, C. Semerad, 1999, Immunity.

Novel strategies for hematopoietic stem cell mobilization

D. Link, J. Dipersio, S. Devine, 2004 .

Regulation of lipopolysaccharide-induced increases in neutrophil glucose uptake.

D. Link, S. Brody, Z. Zhou, 2007, American journal of physiology. Lung cellular and molecular physiology.

mature neutrophils STAT3 governs distinct pathways in emergency granulopoiesis and

M. Goldsmith, D. Link, A. Smith, 2013 .

Generator-Produced Bi-212: Chelated to Chemically Modified Monoclonal Antibody for Use in Radiotherapy

D. Scheinberg, D. Link, A. M. Friedman, 1984 .

The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo

D. Link, M. Zutter, 1995 .

Upregulation of Interleukin 6 and Granulocyte Colony-Stimulating Factor Receptors by Transcription Factor CCAAT Enhancer Binding Protein a (C/EBP

D. Tenen, A. Iwama, D. Link, 1998 .

Suppression of CXCL12 production by bone marrow osteoblasts is a common and critical pathway for cytokine-induced mobilization.

D. Link, Fulu Liu, Fanxin Long, 2007, Blood.

Src family kinases are important negative regulators of G-CSF-dependent granulopoiesis.

C. Mermel, D. Link, Fulu Liu, 2006, Blood.

Enhancing hematopoietic growth factor performance

D. Link, Yen-Michael S. Hsu, 2012, Nature Medicine.

Organ-on-a-chip model of vascularized human bone marrow niches.

Peter A. Sariano, D. Link, Jeremy M. Lowen, 2021, Biomaterials.

Organ-on-a-chip model of vascularized human bone marrow niches

Peter A. Sariano, D. Link, S. George, 2020, bioRxiv.

G-CSF regulates hematopoietic stem cell activity, in part, through activation of toll-like receptor signaling

D. Link, P. Gopalan, L. Schuettpelz, 2014, Leukemia.

Dual functions of cell-autonomous and non-cell-autonomous ADAM10 activity in granulopoiesis.

K. Horiuchi, Y. Okada, D. Link, 2011, Blood.

Mechanisms of Growth Factor Mobilization of Hematopoietic Progenitors

D. Link, 1999 .

Expression of the G-CSF receptor on hematopoietic progenitor cells is not required for their mobilization by G-CSF.

D. Link, Fulu Liu, F. Liu, 2000, Blood.

The granulocyte colony-stimulating factor receptor is required for the mobilization of murine hematopoietic progenitors into peripheral blood by cyclophosphamide or interleukin-8 but not flt-3 ligand.

D. Link, Fulu Liu, F. Liu, 1997, Blood.

Divergent Pathways in COS-7 Cells Mediate Defective Internalization and Intracellular Routing of Truncated G-CSFR Forms in SCN/AML

D. Link, B. Avalos, Alexander Copelan, 2008, PloS one.

Stem cell mobilization.

D. Link, J. Dipersio, O. Kollet, 2003, Hematology. American Society of Hematology. Education Program.

A functional granulocyte colony-stimulating factor receptor is required for normal chemoattractant-induced neutrophil activation.

T. Betsuyaku, D. Link, K. Matsushima, 1999, The Journal of clinical investigation.

Osteoclasts are dispensable for hematopoietic progenitor mobilization by granulocyte colony-stimulating factor in mice.

D. Link, A. Schmidt, Mahil Rao, 2015, Experimental hematology.

Osteoclasts are Dispensable for Hematopoietic Progenitor Mobilization by G-CSF in Mice

D. Link, A. Schmidt, Mahil Rao, 2015 .

Gasdermin D mediates the pathogenesis of neonatal-onset multisystem inflammatory disease in mice

D. Link, Y. Alippe, R. Civitelli, 2018, PLoS biology.

Regulation of systemic and local neutrophil responses by G-CSF during pulmonary Pseudomonas aeruginosa infection.

D. Link, T. Ferkol, Lisa A Hogue, 2004, Blood.

Neutrophil elastase mutations and risk of leukaemia in severe congenital neutropenia

P. Rosenberg, P. Newburger, D. Link, 2007, British journal of haematology.

Specific Signals Generated by the Cytoplasmic Domain of the Granulocyte Colony-Stimulating Factor (G-CSF) Receptor Are Not Required for G-CSF–Dependent Granulocytic Differentiation

D. Link, S. Raptis, J. Jacob, 1998 .

Specific signals generated by the cytoplasmic domain of the granulocyte colony-stimulating factor (G-CSF) receptor are not required for G-CSF-dependent granulocytic differentiation.

D. Link, S. Raptis, J. Jacob, 1998, Blood.

HLA-Matched Sibling Donor Stem Cell Mobilization Can Be Safely and Effectively Reduced from a Five Day to a One Day Process by a Direct Antagonist of the CXCR4/SDF-1 Interaction.

R. Vij, D. Link, J. Dipersio, 2006 .

Csf 3 r mutations in mice confer a strong clonal HSC advantage via activation of Stat 5

M. Tomasson, L. Hennighausen, D. Link, 2008 .

Shaping clonal hematopoiesis.

D. Link, 2020, Blood.

The Role Of Early TP53 Mutations On The Evolution Of Therapy-Related AML

Christopher A. Miller, R. Wilson, R. Fulton, 2013 .

The proto-oncogene c-fgr is expressed in normal mantle zone B lymphocytes and is developmentally regulated during myelomonocytic differentiation in vivo.

D. Link, M. Zutter, 1995, Blood.

Shwachman-Diamond syndrome gene are present in most patients with SBDS Mutations of the

R. Wilson, P. Minx, D. Link, 2011 .

Microbiota Signals Suppress B Lymphopoiesis With Aging in Mice

F. Gao, D. Link, L. Schuettpelz, 2021, Frontiers in Immunology.

1,25‐Dihydroxyvitamin D3 Induces Monocytic Differentiation of the PLB‐985 Leukemic Line and Promotes c‐fgr mRNA Expression

T. Ley, S. Perkins, D. Link, 1991, Journal of leukocyte biology.

TGF-β signaling in myeloproliferative neoplasms contributes to myelofibrosis without disrupting the hematopoietic niche

D. Link, K. Oetjen, Haoliang Xu, 2022, The Journal of clinical investigation.

Marrow Adipose Tissue Expansion Coincides with Insulin Resistance in MAGP1-Deficient Mice

D. Link, R. Mecham, E. Scheller, 2016, Front. Endocrinol..

Impaired production and increased apoptosis of neutrophils in granulocyte colony-stimulating factor receptor-deficient mice.

D. Link, R. Wesselschmidt, Fulu Liu, 1996, Immunity.

Bone Marrow-Derived Aldehyde Dehdrogenase Expressing Cells Possess Endothelial Progenitor Function in Addition to Hematopoietic Repopulating Ability and Aid in Blood Flow Recovery after Acute Ischemic Injury.

D. Link, J. Nolta, Benjamin J. Capoccia, 2005 .

G-CSF Treatment Induces Toll-Like Receptor Signaling and Regulates Hematopoietic Stem Cell Function

D. Link, P. Gopalan, J. Woloszynek, 2013 .

Cooperating, congenital neutropenia–associated Csf3r and Runx1 mutations activate pro-inflammatory signaling and inhibit myeloid differentiation of mouse HSPCs

A. Schambach, L. Kanz, D. Link, 2020, Annals of Hematology.

PTEN regulates natural killer cell trafficking in vivo

Bijal A. Parikh, D. Link, T. Fehniger, 2014, Proceedings of the National Academy of Sciences.

CXCR2 is the Tpo of the iceberg.

D. Link, A. Greenbaum, Adam M. Greenbaum, 2011, Blood.

Stem cells on the move

D. Link, 2010, Nature Medicine.

Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity.

Dustin J. Maxwell, D. Link, D. Piwnica-Worms, 2009, Blood.

using plerixafor, an antagonist of the CXCR4/SDF-1 interaction Rapid mobilization of functional donor hematopoietic cells without G-CSF

R. Vij, P. Westervelt, D. Link, 2011 .

Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction.

R. Vij, P. Westervelt, D. Link, 2008, Blood.

Caspase-9 is required for normal hematopoietic development and protection from alkylator-induced DNA damage in mice.

Christopher A. Miller, R. Wilson, R. Fulton, 2014, Blood.

Radiation induces iatrogenic immunosuppression by indirectly affecting hematopoiesis in bone marrow

D. Hallahan, Xiaowei Wang, D. Link, 2020, Oncotarget.

A novel c-fgr exon utilized in Epstein-Barr virus-infected B lymphocytes but not in normal monocytes

T. Ley, D. Link, P. Lacal, 1991, Molecular and cellular biology.

Megakaryocytes in the hematopoietic stem cell niche

D. Link, Ryan B Day, 2014, Nature Medicine.

miR-125b promotes leukemogenesis via VEGFA.

D. Link, T. Wong, Terrence N Wong, 2017, Blood.

Comment on Liu et al , page 1491 miR-125 b promotes leukemogenesis via VEGFA

D. Link, T. Wong, 2017 .

NIH SenNet Consortium to map senescent cells throughout the human lifespan to understand physiological health.

Philip D. Blood, Ellen M. Quardokus, Matthew A. Wyczalkowski, 2022, Nature aging.

Clonal Hematopoiesis and Risk of Incident Lung Cancer

Christopher A. Miller, B. Ebert, M. Walter, 2022, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Quantifying ultra-rare pre-leukemic clones via targeted error-corrected sequencing

T. Ley, T. Druley, S. Heath, 2015, Leukemia.

Functional heterogeneity of genetically defined subclones in acute myeloid leukemia.

Christopher A. Miller, R. Wilson, R. Fulton, 2014, Cancer cell.

CXCR2 and CXCR4 antagonistically regulate neutrophil trafficking from murine bone marrow.

D. Link, P. Gopalan, A. Greenbaum, 2010, The Journal of clinical investigation.

Identification of somatic JAK1 mutations in patients with acute myeloid leukemia.

R. Wilson, E. Mardis, M. McLellan, 2008, Blood.

Radiation causes tissue damage by dysregulating inflammasome–gasdermin D signaling in both host and transplanted cells

D. Link, J. Monahan, Y. Alippe, 2020, PLoS biology.

The diversity of mutations and clinical outcomes for ELANE-associated neutropenia

P. Rosenberg, P. Newburger, D. Link, 2015, Current opinion in hematology.

Mutations of the ELA2 gene found in patients with severe congenital neutropenia induce the unfolded protein response and cellular apoptosis.

Jun Xia, David Dale, D. Link, 2006, Blood.

Tumor-induced STAT3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

Jonathan B. Mitchem, D. Link, D. Sanford, 2014, Cancer Immunology, Immunotherapy.

p120 nucleolar‐proliferating antigen is a direct target of G‐CSF signaling during myeloid differentiation

D. Link, Hong Sun, P. Ghosh, 2006, Journal of leukocyte biology.

Impaired myelopoiesis in congenital neutropenia: insights into clonal and malignant hematopoiesis.

D. Link, J. Warren, 2021, Hematology. American Society of Hematology. Education Program.

Mechanisms of leukemic transformation in congenital neutropenia

D. Link, 2019, Current opinion in hematology.

Lentiviral-mediated RNAi inhibition of Sbds in murine hematopoietic progenitors impairs their hematopoietic potential.

D. Link, Fulu Liu, J. Woloszynek, 2007, Blood.

CpG Island Hypermethylation Mediated by DNMT3A Is a Consequence of AML Progression

R. Wilson, R. Fulton, T. Ley, 2017, Cell.

TP53 and Decitabine in Acute Myeloid Leukemia and Myelodysplastic Syndromes.

Christopher A. Miller, R. Wilson, R. Fulton, 2016, The New England journal of medicine.

microRNA transcriptome Next-generation sequencing identifies the natural killer cell Material

E. Mardis, D. Koboldt, T. Ley, 2016 .

MicroRNA-223 Regulates Granulopoiesis but Is Not Required for HSC Maintenance in Mice

D. Link, Maria C Trissal, A. Schmidt, 2015, PloS one.

Next-generation sequencing identifies the natural killer cell microRNA transcriptome.

Todd Wylie, Rakesh Nagarajan, Todd A Fehniger, 2010, Genome research.

Regulation of Hematopoietic Stem Cell Activity by Inflammation

D. Link, L. Schuettpelz, Laura G. Schuettpelz, 2013, Front. Immunol..

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Christopher A. Miller, R. Fulton, T. Ley, 2018, Nature Communications.

Pivotal role of granulocyte colony-stimulating factor in the development of progenitors in the common myeloid pathway.

K. Akashi, H. Iwasaki, D. Link, 2003, Blood.

The Role of TP53 Mutations in the Origin and Evolution of Therapy-Related AML

Christopher A. Miller, R. Wilson, R. Fulton, 2014, Nature.

Genomics of AML: clinical applications of next-generation sequencing.

J. Welch, D. Link, John S Welch, 2011, Hematology. American Society of Hematology. Education Program.

arising in the setting of severe congenital neutropenia Distinct patterns of mutations occurring in de novo AML versus AML

E. Mardis, C. Bloomfield, M. McLellan, 2013 .

Distinct patterns of mutations occurring in de novo AML versus AML arising in the setting of severe congenital neutropenia.

R. Wilson, E. Mardis, M. Caligiuri, 2007, Blood.

Upregulation of interleukin 6 and granulocyte colony-stimulating factor receptors by transcription factor CCAAT enhancer binding protein alpha (C/EBP alpha) is critical for granulopoiesis.

Pu Zhang, Daniel G. Tenen, Atsushi Iwama, 1998 .

DNMT 3 A mutations in acute myeloid leukemia

Joshua F. McMichael, Cheryl F. Lichti, R. Wilson, 2016 .

Cysteine3 of Src family protein tyrosine kinase determines palmitoylation and localization in caveolae

D. Link, D. Dietzen, D. Lublin, 1994, The Journal of cell biology.

Clonal diversity of recurrently mutated genes in myelodysplastic syndromes

E Mardis, R. Fulton, E. Mardis, 2013, Leukemia.

Soil and Seed: Coconspirators in Therapy-Induced Myeloid Neoplasms.

D. Link, K. Shannon, 2020, Blood cancer discovery.

Dynamic Changes in the Clonal Structure of MDS and AML in Response to Epigenetic Therapy

Christopher A. Miller, R. Wilson, R. Fulton, 2016, Leukemia.

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

Christopher A. Miller, R. Wilson, R. Fulton, 2016, Blood.

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.

Christopher A. Miller, R. Wilson, R. Fulton, 2015, JAMA.

Supplementary Materials Rationale for Selection an Aml Genome for Sequencing. We Selected a Specific Genome for Study Based on the following Criteria

Amy E. Hawkins, Brian H. Dunford-Shore, R. Wilson, 2022 .

Immune Escape of Relapsed AML Cells after Allogeneic Transplantation

Christopher A. Miller, R. Wilson, R. Fulton, 2018, The New England journal of medicine.

Mutation Clearance after Transplantation for Myelodysplastic Syndrome

R. Fulton, T. Ley, J. Welch, 2018, The New England journal of medicine.

Subclones dominate at MDS progression following allogeneic hematopoietic cell transplant.

Christopher A. Miller, R. Fulton, T. Ley, 2018, JCI insight.

TP 53 and decitabine in acute myeloid leukemia and myelodysplastic syndromes

R. Fulton, T. Ley, J. Welch, 2016 .

The hematopoietic stem cell niche in homeostasis and disease.

D. Link, L. Calvi, 2015, Blood.

Characterization of the 5' untranslated region of the human c-fgr gene and identification of the major myelomonocytic c-fgr promoter.

T. Ley, D. Link, K. Robbins, 1992, Oncogene.

Suppression of apoptosis during cytokine deprivation of 32D cells is not sufficient to induce complete granulocytic differentiation.

D. Link, J. Rodel, 1996, Blood.

Genomic landscape of TP53-mutated myeloid malignancies

Christopher A. Miller, R. Fulton, T. Ley, 2023, medRxiv.

STAT-3 activation is required for normal G-CSF-dependent proliferation and granulocytic differentiation.

D. Link, Fulu Liu, S. Grewal, 2001, Immunity.

Cellular stressors contribute to the expansion of hematopoietic clones of varying leukemic potential

Christopher A. Miller, R. Fulton, T. Ley, 2018, Nature Communications.

Genomic analysis of germ line and somatic variants in familial myelodysplasia/acute myeloid leukemia.

Christopher A. Miller, R. Fulton, D. Koboldt, 2015, Blood.

G-CSF induced progenitor mobilization in mice with PIGA- blood cells.

D. Link, Fulu Liu, M. Bessler, 2004, The hematology journal : the official journal of the European Haematology Association.

RECURRENT MUTATIONS IN THE U2AF1 SPLICING FACTOR IN MYELODYSPLASTIC SYNDROMES

Li Ding, Kilannin Krysiak, David E. Larson, 2011, Nature Genetics.

Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

D. Link, F. Hsu, C. Semenkovich, 2015, Cell metabolism.

STAT3 governs distinct pathways in emergency granulopoiesis and mature neutrophils.

M. Goldsmith, D. Link, A. D. Panopoulos, 2006, Blood.

Comprehensive discovery of noncoding RNAs in acute myeloid leukemia cell transcriptomes.

Christopher A. Miller, R. Wilson, R. Fulton, 2017, Experimental hematology.

Genome Sequencing as an Alternative to Cytogenetic Analysis in Myeloid Cancers.

Christopher A. Miller, R. Fulton, T. Ley, 2021, The New England journal of medicine.

Comprehensive genomic analysis reveals FLT3 activation and a therapeutic strategy for a patient with relapsed adult B-lymphoblastic leukemia.

Benjamin J. Ainscough, Katie M. Campbell, James M. Eldred, 2016, Experimental hematology.

‘CHIP’ping away at clonal hematopoiesis

M. Walter, D. Link, 2016, Leukemia.

Acquired copy number alterations in adult acute myeloid leukemia genomes

J. Kitzman, R. Wilson, R. Fulton, 2009, Proceedings of the National Academy of Sciences.

Mechanisms of Disordered Granulopoiesis in Congenital Neutropenia

D. Link, D. Grenda, 2006 .

Nonsense Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells with SF3B1 and U2AF1 Mutations

Shondra M. Pruett-Miller, M. Walter, Xiaowei Wang, 2021, bioRxiv.

Stable long‐term risk of leukaemia in patients with severe congenital neutropenia maintained on G‐CSF therapy

Philip S Rosenberg, Akiko Shimamura, P. Rosenberg, 2010, British journal of haematology.

Regulation of neutrophil homeostasis

D. Link, M. Christopher, Matthew J. Christopher, 2007, Current opinion in hematology.

Update On the Risk of Leukemia in Genetic Subgroups of Congenital Neutropenia (CN): Comparison of Patients with Known Gene Mutations (ELA2, HAX1, WASP, G6PC3, p14).

C. Klein, D. Link, K. Welte, 2009 .

Heterozygous Variants of CLPB are a Cause of Severe Congenital Neutropenia.

D. Spencer, D. Link, A. Locke, 2021, Blood.

MIR142 Loss-of-Function Mutations Derepress ASH1L to Increase HOXA Gene Expression and Promote Leukemogenesis.

T. Ley, J. Baty, D. Link, 2018, Cancer research.

Nonsense-Mediated RNA Decay Is a Unique Vulnerability of Cancer Cells Harboring SF3B1 or U2AF1 Mutations

Shondra M. Pruett-Miller, M. Walter, Xiaowei Wang, 2021, Cancer Research.

Canonical signaling by TGF family members in mesenchymal stromal cells is dispensable for hematopoietic niche maintenance under basal and stress conditions

D. Link, Juo-Chin Yao, J. Krambs, 2019, PloS one.

TGF-β Signaling Plays an Essential Role in the Lineage Specification of Mesenchymal Stem/Progenitor Cells in Fetal Bone Marrow

D. Link, Hamza Celik, Jingzhu Zhang, 2019, Stem cell reports.

CXCL12 Production by Early Mesenchymal Progenitors is Required for Hematopoietic Stem Cell Maintenance

D. Link, T. Nagasawa, L. Schuettpelz, 2012, Nature.

N-cadherin in osteolineage cells is not required for maintenance of hematopoietic stem cells.

D. Link, R. Civitelli, J. Woloszynek, 2011, Blood.

tyrosine kinase genes of patients with de novo acute myeloid leukemia Somatic mutations and germline sequence variants in the expressed

R. Wilson, C. Bloomfield, M. McLellan, 2013 .

Characterization of hematopoietic progenitor mobilization in protease-deficient mice.

T. Betsuyaku, D. Link, J. Lévesque, 2004, Blood.

Mice expressing a neutrophil elastase mutation derived from patients with severe congenital neutropenia have normal granulopoiesis.

D. Link, M. Horwitz, Daniel C Link, 2002, Blood.

MicroRNA-142 Is Critical for the Homeostasis and Function of Type 1 Innate Lymphoid Cells.

D. Link, M. Colonna, Ming O. Li, 2019, Immunity.

Proteomic and phosphoproteomic landscapes of acute myeloid leukemia

T. Ley, M. Walter, J. Payton, 2022, Blood.

Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.

K. Trinkaus, D. Link, Jingzhu Zhang, 2019, The Journal of clinical investigation.

The number of endothelial progenitor cell colonies in the blood is increased in patients with angiographically significant coronary artery disease.

D. Link, R. Bach, Benjamin J. Capoccia, 2006, Journal of the American College of Cardiology.

Targeting of Mesenchymal Stromal Cells by Cre‐Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells

D. Link, Jingzhu Zhang, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

N‐cadherin Regulation of Bone Growth and Homeostasis Is Osteolineage Stage–Specific

D. Link, Y. Alippe, R. Civitelli, 2017, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Activation of Tyk2 and Stat3 Is Required for the Apoptotic Actions of Interferon-β in Primary Pro-B Cells*

D. Link, D. Baker, J. Węgrzyn, 2006, Journal of Biological Chemistry.

A pilot study of high-throughput, sequence-based mutational profiling of primary human acute myeloid leukemia cell genomes

R. Wilson, E. Mardis, M. Caligiuri, 2003, Proceedings of the National Academy of Sciences of the United States of America.

A Pilot Study Evaluating the Safety and Efficacy of AMD3100 for the Mobilization and Transplantation of HLA-Matched Sibling Donor Hematopoietic Stem Cells in Patients with Advanced Hematological Malignancies.

R. Vij, D. Link, J. Dipersio, 2004 .

Tumor-induced STAT 3 activation in monocytic myeloid-derived suppressor cells enhances stemness and mesenchymal properties in human pancreatic cancer

Jonathan B. Mitchem, D. Link, D. Sanford, 2015 .

Identification of somatic JAK 1 mutations in patients with acute myeloid leukemia

R. Wilson, E. Mardis, M. McLellan, 2008 .

TGFβR-SMAD3 Signaling Induces Resistance to PARP Inhibitors in the Bone Marrow Microenvironment.

R. Levine, D. Link, I. Tempera, 2020, Cell reports.

Targeting VLA 4 integrin and CXCR 2 mobilizes serially repopulating hematopoietic stem cells

A. Trumpp, D. Griggs, F. Gao, 2019 .

Mutational landscape and response are conserved in peripheral blood of AML and MDS patients during decitabine therapy.

Christopher A. Miller, R. Wilson, R. Fulton, 2017, Blood.

Mechanisms of mobilization of hematopoietic progenitors with granulocyte colony-stimulating factor

D. Link, Fulu Liu, Johnson Thomas, 2002, Current opinion in hematology.

G-CSF Disrupts the Stem Cell Niche by Increasing Turnover of Bone Marrow Osteoblasts.

D. Link, P. Gopalan, M. Christopher, 2006 .

Regulation of neutrophil trafficking from the bone marrow

D. Link, Ryan B Day, 2012, Cellular and Molecular Life Sciences.

Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia.

P. Newburger, D. Link, A. Shimamura, 2017, The New England journal of medicine.

Complete characterization of the microRNAome in a patient with acute myeloid leukemia.

Li Ding, Todd Wylie, Rakesh Nagarajan, 2010, Blood.

leukemia Identification of somatic JAK1 mutations in patients with acute myeloid

R. Wilson, E. Mardis, M. McLellan, 2013 .

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Joshua D. Welch, D. Link, K. Kozloff, 2020, Nature Communications.

A Wnt-mediated transformation of the bone marrow stromal cell identity orchestrates skeletal regeneration

Joshua D. Welch, D. Link, K. Kozloff, 2020, Nature Communications.

Regulation of granulopoiesis: lessons from leukocyte adhesion deficiency

D. Link, 2001 .

A pilot study evaluating the safety and efficacy of AMD3100 for the mobilization and transplantation of HLA-matched sibling donor hematopoietic stem cells in patients with advanced hematological malignancies

D. Link, J. Dipersio, J. Nolta, 2005 .

IL-1b expression in bone marrow dendritic cells is induced by TLR2 agonists and regulates HSC function.

R. Fulton, T. Ley, M. Walter, 2022, Blood.

Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia

Christopher A. Miller, R. Fulton, T. Ley, 2021, Blood cancer discovery.

Title: Genetic and Transcriptional Contributions to Relapse in Normal Karyotype Acute Myeloid Leukemia Authors and Affiliations:

Christopher A. Miller, T. Ley, M. Walter, 2021 .

Cellular Complexity of the Bone Marrow Hematopoietic Stem Cell Niche

D. Link, L. Calvi, 2013, Calcified Tissue International.

Outcomes of Pregnancies for Women with Severe Chronic Neutropenia with or without G-CSF Treatment.

P. Rosenberg, P. Newburger, D. Link, 2010 .

The Risk of Low Bone Mineral Density with Long-Term G-CSF Therapy for Severe Chronic Neutropenia.

P. Rosenberg, P. Newburger, D. Link, 2010 .

Subclonal Evolution Characterizes MDS Disease Progression Following Allogeneic Stem Cell Transplant

Christopher A. Miller, R. Fulton, T. Ley, 2017 .

Regulation of Hematopoiesis by CXCL12/CXCR4 Signaling

D. Link, 2015 .

Disruption of SDF-1/CXCR4 Signaling during Flt-3 Ligand and Stem Cell Factor (SCF) Induced Hematopoietic Progenitor Mobilization.

D. Link, Fulu Liu, M. Christopher, 2004 .

G-CSF treatment induces a significant decrease in CXCL12 mRNA expression in the bone marrow

D. Link, Fulu Liu, C. Semerad, 2003 .

Expression of the G-CSF Receptor in Monocytes Is Sufficient to Mediate Osteoblast Suppression and HSPC Mobilization by G-CSF in Mice.

D. Link, Fulu Liu, J. Woloszynek, 2009 .

Contribution of granulocyte colony-stimulating factor to the acute mobilization of endothelial precursor cells by vascular disrupting agents.

A. Harris, G. Rustin, D. Link, 2009, Cancer research.

Mutant p53 drives clonal hematopoiesis through modulating epigenetic pathway

Eric R. Wolf, Yan Liu, D. Link, 2019, Nature Communications.

TLR7/8 Agonist Treatment Induces an Increase in Bone Marrow Resident Dendritic Cells and Hematopoietic Progenitor Expansion and Mobilization.

D. Link, A. Schmidt, Juo-Chin Yao, 2021, Experimental hematology.

Cytokines and stem cell mobilization for autologous and allogeneic transplantation.

D. Link, J. Dipersio, S. Devine, 2004, Current hematology reports.

Comprehensive Evaluation of MicroRNA Genes and Gene Expression Using Next Generation Sequencing in a Patient with Acute Myelogenous Leukemia.

E. Mardis, D. Koboldt, T. Ley, 2009 .

SNAREing a new cause of neutropenia.

D. Link, 2013, Blood.

Dicer and outcomes in patients with acute myeloid leukemia (AML).

J. Payton, D. Link, Mike G Martin, 2009, Leukemia research.

Interleukin-6 and the granulocyte colony-stimulating factor receptor are major independent regulators of granulopoiesis in vivo but are not required for lineage commitment or terminal differentiation.

D. Link, Fulu Liu, F. Liu, 1997, Blood.

Focal disruption of DNA methylation dynamics at enhancers in IDH-mutant AML cells

Christopher A. Miller, R. Fulton, T. Ley, 2021, Leukemia.

Genomic landscape of TP53-mutated myeloid malignancies

R. Fulton, T. Ley, M. Walter, 2023, Blood advances.

Imaging Mass Cytometry Reveals the Spatial Architecture of Myelodysplastic Syndromes and Secondary Acute Myeloid Leukemias

D. Link, K. Oetjen, D. Bender, 2020 .

Recurrent transcriptional responses in AML and MDS patients treated with decitabine

Nakul M. Shah, Christopher A. Miller, T. Ley, 2022, Experimental Hematology.

Increased clonal hematopoiesis involving DNA damage response genes in patients undergoing lung transplantation

M. Walter, D. Kreisel, D. Link, 2023, JCI insight.

Acquired copy number alterations of miRNA genes in acute myeloid leukemia are uncommon.

T. Ley, M. Walter, D. Shen, 2013, Blood.

The Expression Signature of M3 AML Suggests Direct and Indirect Effects of PML-RARA on Target Genes.

T. Ley, M. Watson, J. Payton, 2007 .

Staphylococcal food poisoning.

A. L. Wong, J. Gécz, M. Rietschel, 2002 .

Genome-wide analysis of focal DNA hypermethylation in IDH-mutant AML samples

Christopher A. Miller, R. Fulton, T. Ley, 2021, bioRxiv.

Kruppel-like factor 7 overexpression suppresses hematopoietic stem and progenitor cell function.

D. Link, F. Giuste, P. Gopalan, 2012, Blood.

The α2β1 Integrin Regulates Hematopoietic Stem Cell Engraftment.

D. Link, M. Zutter, A. Sheehan, 2006 .

Peroxisomal lipid synthesis regulates inflammation by sustaining neutrophil membrane phospholipid composition and viability.

D. Link, F. Hsu, C. Semenkovich, 2015, Cell metabolism.

Bone marrow dendritic cells regulate hematopoietic stem/progenitor cell trafficking.

K. Trinkaus, D. Link, Jingzhu Zhang, 2019, The Journal of clinical investigation.

shRNA-mediated decreases in c-Met levels affect the differentiation potential of human mesenchymal stem cells and reduce their capacity for tissue repair.

D. Link, J. Nolta, Ivana Rosová, 2010, Tissue engineering. Part A.

Hypoxic Preconditioning Results in Increased Motility and Improved Therapeutic Potential of Human Mesenchymal Stem Cells

D. Link, J. Nolta, Benjamin J. Capoccia, 2008, Stem cells.

Rapid mobilization of functional donor hematopoietic cells without G-CSF using AMD3100, an antagonist of the CXCR4/SDF-1 interaction.

R. Vij, P. Westervelt, D. Link, 2008, Blood.

High throughput digital quantification of mRNA abundance in primary human acute myeloid leukemia samples.

T. Ley, M. Watson, J. Payton, 2009, Journal of Clinical Investigation.

Commonly dysregulated genes in murine APL cells.

T. Ley, M. Watson, J. Payton, 2007, Blood.

Stem cell mobilization.

D. Link, J. Dipersio, O. Kollet, 2003, Hematology. American Society of Hematology. Education Program.

Long-Term Effects of G-CSF Therapy in Cyclic Neutropenia.

P. Newburger, D. Link, A. Shimamura, 2017, The New England journal of medicine.

Increased Incidence of Clonal Hematopoiesis in Lung Transplant Recipients Involves DNA Damage Response Genes

D. Link, K. Oetjen, L. Tague, 2021, Blood.

Association Between Mutation Clearance After Induction Therapy and Outcomes in Acute Myeloid Leukemia.

Christopher A. Miller, R. Fulton, E. Mardis, 2015, JAMA.

Targeting of Mesenchymal Stromal Cells by Cre‐Recombinase Transgenes Commonly Used to Target Osteoblast Lineage Cells

D. Link, Jingzhu Zhang, 2016, Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research.

Csf3r mutations in mice confer a strong clonal HSC advantage via activation of Stat5.

M. Tomasson, L. Hennighausen, D. Link, 2008, The Journal of clinical investigation.

Sitosterolemia

A. L. Wong, J. Gécz, A. Pitkänen, 2020, Definitions.

Stable Long-Term Risk of Leukemia in Patients with Severe Congenital Neutropenia Maintained On G-CSF Therapy.

P. Rosenberg, P. Newburger, D. Link, 2009 .

Co-Acquisition of RUNX1 and CSF3R Mutations Transforms Hematopoietic Progenitor Cells of CN Patients into More Primitive Highly Proliferative Blasts: Evidence in CN Patients and in a Mouse Model

D. Link, K. Welte, C. Stocking, 2014 .

Convergent Clonal Evolution of Signaling Gene Mutations Is a Hallmark of Myelodysplastic Syndrome Progression.

Christopher A. Miller, Matthew J. Schuelke, R. Fulton, 2022, Blood cancer discovery.

Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML.

Christopher A. Miller, R. Fulton, E. Mardis, 2016, Blood.

MYELOID NEOPLASIA Rapid expansion of preexisting nonleukemic hematopoietic clones frequently follows induction therapy for de novo AML