J. Parrillo

J. Parrillo, J. Calvin, M. Costanzo, 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

The contemporary management of acute myocardial infarction.

J. Parrillo, F. Almeda, R. Snell, 2001, Critical care clinics.

Detection of renal blood flow abnormalities in septic and critically ill patients using a newly designed indwelling thermodilution renal vein catheter.

J. Parrillo, G. Schaer, A. Suffredini, 1990, Chest.

Experimental human endotoxemia is associated with depression of load-independent contractility indices: prevention by the lipid a analogue E5531.

Anand Kumar, J. Parrillo, A. Neumann, 2004, Chest.

Verapamil and adriamycin in the treatment of drug-resistant ovarian cancer patients.

Y. Ostchega, R. Ozols, J. Parrillo, 1987, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Reduction in Reperfusion‐Induced Myocardial Necrosis in Dogs by RheothRx Injection (Poloxamer 188 N.F.), a Hemorheological Agent That Alters Neutrophil Function

J. Parrillo, G. Schaer, E. Rodriguez, 1994, Circulation.

Accurate noninvasive estimation of left ventricular end-diastolic pressure: comparison with catheterization.

J. Parrillo, J. Soble, A. Neumann, 1998, Journal of the American Society of Echocardiography : official publication of the American Society of Echocardiography.

Nitric oxide synthase inhibition increases venular leukocyte rolling and adhesion in septic rats

J. Parrillo, S. Hollenberg, C. Easington, 2000, Critical care medicine.

Electrocardiographic diagnosis of acute myocardial infarction: Current concepts for the clinician.

J. Parrillo, Y. Birnbaum, E. Sgarbossa, 2001, American heart journal.

Effect of large volume infusion on left ventricular volumes, performance and contractility parameters in normal volunteers

J. Parrillo, M. Cheang, R. Rosenson, 2004, Intensive Care Medicine.

Preload-independent mechanisms contribute to increased stroke volume following large volume saline infusion in normal volunteers: a prospective interventional study

Anand Kumar, J. Parrillo, S. Zanotti, 2004, Critical care.

Changes in coronary endothelial function predict progression of allograft vasculopathy after heart transplantation.

L. Klein, J. Parrillo, S. Hollenberg, 2004, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Transcriptional Regulation of Fas Gene Expression by GA-binding Protein and AP-1 in T Cell Antigen Receptor·CD3 Complex-stimulated T Cells*

J. Parrillo, Aseem Kumar, R. Kimberly, 1999, The Journal of Biological Chemistry.

Effect of Poloxamer 188 on Collateral Blood Flow, Myocardial Infarct Size, and Left Ventricular Function in a Canine Model of Prolonged (3-Hour) Coronary Occlusion and Reperfusion

R. F. Kelly, J. Parrillo, G. Schaer, 1998, Journal of Thrombosis and Thrombolysis.

Nonspecific interstitial pneumonitis: a common cause of pulmonary disease in the acquired immunodeficiency syndrome.

F. Ognibene, J. Shelhamer, A. Fauci, 1987, Annals of internal medicine.

Norepinephrine alone versus norepinephrine plus low-dose dopamine: enhanced renal blood flow with combination pressor therapy.

J. Parrillo, M. Fink, G. Schaer, 1985 .

Utilization of coronary angiography and revascularization after acute myocardial infarction in men and women risk stratified by the American College of Cardiology/American Heart Association guidelines.

R. F. Kelly, J. Parrillo, J. Calvin, 2000, Journal of the American College of Cardiology.

Coronary Endothelial Dysfunction After Heart Transplantation Predicts Allograft Vasculopathy and Cardiac Death

L. Klein, J. Parrillo, S. Hollenberg, 2002, Circulation.

Myocarditis and Acute Myopathies

J. Parrillo, F. Ginsberg, 2011 .

Acute Heart Failure and Myocarditis

J. Parrillo, F. Ginsberg, 2008 .

The intermediate CCU admission: a preliminary study.

L. Klein, J. Parrillo, J. Calvin, 2001, Heart disease.

Cofactors V and VIII after endotoxin administration to human volunteers.

R. Colman, J. Parrillo, A. Suffredini, 1995, Thrombosis research.

clinical investigations in critical care Right Ventricular Dysfunction and Dilatation , Similar to Left Ventricular Changes , Characterize the Cardiac Depression of Septic Shock in Humans *

F. Ognibene, J. Parrillo, M. Parker, 2006 .

Disseminated Mycobacterium haemophilum infection in two patients with the acquired immunodeficiency syndrome.

J. Kovacs, R. Walker, H. Masur, 1988, The American journal of medicine.

The golden hour of right ventricular ischemia.

J. Parrillo, Andrew Yen, 2008, Critical care medicine.

Chronic granulomatous disease. Diagnosis in a 27-year-old man with Mycobacterium fortuitum.

A. Fauci, J. Parrillo, M. Chusid, 1975, JAMA.

Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter

J. Parrillo, Aseem Kumar, J. Platt, 2002, The Journal of Biological Chemistry.

Therapeutic hypothermia and vasopressor dependency after cardiac arrest.

J. Parrillo, S. Trzeciak, B. Roberts, 2013, Resuscitation.

Utility of various clinical, noninvasive, and invasive procedures for determining the causes of recurrence of myocardial ischemia or infarction > or = 1 year after percutaneous transluminal coronary angioplasty.

L. Klein, J. Parrillo, J. Calvin, 1995, The American journal of cardiology.

Morphological and quantitative angiographic analyses of progression of coronary stenoses. A comparison of Q-wave and non-Q-wave myocardial infarction.

H. Kennedy, L. Klein, J. Parrillo, 1994, Circulation.

Cardiogenic shock.

J. Parrillo, S. Hollenberg, C. Kavinsky, 1999, Annals of internal medicine.

Value of the American College of Cardiology/American Heart Association stenosis morphology classification for coronary interventions in the late 1990s.

L. Klein, J. Parrillo, J. Calvin, 1998, The American journal of cardiology.

The SUPPORT project and improving care for seriously ill patients.

J. Parrillo, 1996, JAMA.

Heart disease and the eosinophil.

J. Parrillo, 1990, The New England journal of medicine.

Nonspecific interstitial pneumonitis without evidence of Pneumocystis carinii in asymptomatic patients infected with human immunodeficiency virus (HIV).

F. Ognibene, J. Shelhamer, W. Travis, 1988, Annals of internal medicine.

PROSPECTIVE EVALUATION OF A MONOCLONAL ANTIBODY IN DIAGNOSIS OF PNEUMOCYSTIS CARINII PNEUMONIA

F. Ognibene, J. Kovacs, H. Masur, 1986, The Lancet.

Promotion and subsequent inhibition of plasminogen activation after administration of intravenous endotoxin to normal subjects.

J. Parrillo, A. Suffredini, P. Harpel, 1989, The New England journal of medicine.

Takayasu's arteritis and its therapy.

J. Shelhamer, A. Fauci, J. Parrillo, 1985, Annals of internal medicine.

Norepinephrine alone versus norepinephrine plus low‐dose dopamine: Enhanced renal blood flow with combination pressor therapy

J. Parrillo, M. Fink, G. Schaer, 1985, Critical care medicine.

Location of patients before transfer to a tertiary care intensive care unit: impact on outcome.

J. Parrillo, R. Dellinger, C. Schorr, 2009, Journal of critical care.

Comparison of heparin therapy for < or = 48 hours to > 48 hours in unstable angina pectoris.

L. Klein, J. Parrillo, J. Calvin, 1997, The American journal of cardiology.

Excimer laser ablation before autoperfusion balloon inflation: a novel therapeutic approach to high grade stenoses in vessels supplying substantial myocardium at risk.

P. B. Krause, L. Klein, J. Parrillo, 1992, Catheterization and cardiovascular diagnosis.

The cardiovascular manifestations of the hypereosinophilic syndrome. Prospective study of 26 patients, with review of the literature.

W. Henry, A. Fauci, J. Parrillo, 1979, The American journal of medicine.

Cardiogenic shock.

J. Parrillo, F. Ginsberg, S. Topalian, 2008, Critical care medicine.

A silver anniversary for the Society of Critical Care Medicine--visions of the past and future: the presidential address from the 24th Educational and Scientific Symposium of the Society of Critical Care Medicine.

J. Parrillo, 1995, Critical care medicine.

Improved risk stratification in unstable angina: Identification of patients at low risk for in‐hospital cardiac events by admission echocardiography

J. Parrillo, J. Calvin, J. Stein, 1998, Clinical cardiology.

Targeting host E-selectin expression by antisense oligodeoxynucleotides as potential antiendotoxin therapy in vivo.

J. Parrillo, C. Bennett, T. Condon, 2010, Oligonucleotides.

Discordance between microvascular permeability and leukocyte dynamics in septic inducible nitric oxide synthase deficient mice

J. Parrillo, S. Hollenberg, M. Guglielmi, 2007, Critical care.

Adenosine deaminase inhibition attenuates microvascular dysfunction and improves survival in sepsis.

J. Parrillo, R. Balk, S. Hollenberg, 2002, American journal of respiratory and critical care medicine.

Echocardiography and nuclear cardiac imaging in the critical care unit.

J. Parrillo, M. Parker, R. Cunnion, 1985, JAMA.

Necrotizing vasculitis, coronary angiitis, and the cardiologist.

A. Fauci, J. Parrillo, 1980, American heart journal.

Chapter 5 – Temporary Cardiac Pacing

J. Parrillo, L. Gessman, 2008 .

Worsening hypotension in a 60-year-old man requiring intra-aortic balloon counterpulsation.

J. Parrillo, 1999, Chest.

Effect of nitric oxide synthase inhibition on haemodynamics and outcome of patients with persistent cardiogenic shock complicating acute myocardial infarction: a phase II dose-ranging study.

E. Ohman, S. Hazen, M. Farkouh, 2007, European heart journal.

Antiendotoxin Activity of Lipid A Analogues: Requirements of the Chemical Structure

M. Doerfler, J. Parrillo, R. Danner, 1990, Pharmaceutical Research.

E 3 Which is the right antibiotic treatment for ventilator-associated pneumonia ?

J. Parrillo, 2007 .

Perceptions of a critically ill patient experiencing therapeutic paralysis in an ICU

J. Shelhamer, J. Parrillo, M. Parker, 1984, Critical care medicine.

Positive end expiratory pressure in adults.

J. Shelhamer, C. Natanson, J. Parrillo, 1984, JAMA.

A circulating myocardial depressant substance is associated with cardiac dysfunction and peripheral hypoperfusion (lactic acidemia) in patients with septic shock.

J. Shelhamer, J. Parrillo, M. Parker, 1989, Chest.

Effect of 100% oxygen administration on infarct size and left ventricular function in a canine model of myocardial infarction and reperfusion.

R. F. Kelly, J. Parrillo, G. Schaer, 1995, American heart journal.

A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.

J. Shelhamer, C. Natanson, J. Parrillo, 1985, The Journal of clinical investigation.

NADH/NAD redox state of cytoplasmic glycolytic compartments in vascular smooth muscle.

J. Parrillo, J. T. Barron, L. Gu, 2000, American journal of physiology. Heart and circulatory physiology.

Transvenous endomyocardial biopsy. Clinical indications, potential complications, and future applications.

J. Parrillo, 1986, Chest.

Hypertension and Renin-Angiotensin-Aldosterone System Inhibitors in Patients with Covid-19

J. Parrillo, S. Goldberg, I. Sawczuk, 2020, medRxiv.

The results of transvenous endomyocardial biopsy can frequently be used to diagnose myocardial diseases in patients with idiopathic heart failure. Endomyocardial biopsies in 100 consecutive patients revealed a substantial incidence of myocarditis.

I. Palacios, J. Parrillo, J. Fallon, 1984, Circulation.

Effects of epinephrine and amrinone on contractility and cyclic adenosine monophosphate generation of tumor necrosis factor alpha-exposed cardiac myocytes.

J. Parrillo, A. Kumar, C. Dimou, 1999, Critical care medicine.

compartments in vascular smooth muscle NADH/NAD redox state of cytoplasmic glycolytic

J. Parrillo, J. T. Barron, L. Gu, 2006 .

Endotoxin administration to humans primes alveolar macrophages for increased production of inflammatory mediators

J. Parrillo, S. Wahl, L. Wahl, 1994, Journal of Clinical Immunology.

Cardiac Disease in Myasthenia Gravis: A Literature Review

J. Parrillo, M. Guglin, J. Campellone, 2003, Journal of clinical neuromuscular disease.

Myocardial dysfunction in sepsis. Recent insights.

J. Parrillo, R. Cunnion, 1989, Chest.

Myocardial dysfunction in sepsis.

J. Parrillo, R. Cunnion, 1989, Critical care clinics.

A lipid A analog, E5531, blocks the endotoxin response in human volunteers with experimental endotoxemia

J. Parrillo, L. Friedhoff, C. Perdomo, 2000, Critical care medicine.

Cardiac endothelin release and infarct size, myocardial blood flow, and ventricular function in canine infarction and reperfusion.

R. F. Kelly, J. Parrillo, S. Hollenberg, 1996, Journal of investigative medicine : the official publication of the American Federation for Clinical Research.

Characterization of a hyperdynamic murine model of resuscitated sepsis using echocardiography.

J. Parrillo, S. Hollenberg, S. Colilla, 2001, American journal of respiratory and critical care medicine.

Tumor necrosis factor challenges in canines: patterns of cardiovascular dysfunction.

C. Natanson, S. Banks, J. Parrillo, 1992, The American journal of physiology.

Adult respiratory distress syndrome in patients with severe neutropenia.

F. Ognibene, J. Shelhamer, J. Parrillo, 1986, The New England journal of medicine.

Consensus Statement on the Triage of Critically III Patients

J. Parrillo, B. Chernow, D. Dantzker, 2016 .

Interleukin-2 administration causes reversible hemodynamic changes and left ventricular dysfunction similar to those seen in septic shock.

F. Ognibene, J. Shelhamer, S. Rosenberg, 1988, Chest.

Cytokines and septic myocardial depression: nitric oxide versus sphingosine/ceramide?

J. Parrillo, A. Kumar, 1999, Critical care medicine.

Frequency of myocarditis, left ventricular dysfunction and ventricular tachycardia in the acquired immune deficiency syndrome.

R. Virmani, W. Roberts, A. Fauci, 1988, The American journal of cardiology.

Critical care medicine.

J. Parrillo, 1992, JAMA.

Immunologic reactivity in the hypereosinophilic syndrome.

A. Fauci, J. Parrillo, M. Frank, 1979, The Journal of allergy and clinical immunology.

Human eosinophils. Purification and cytotoxic capability of eosinophils from patients with the hypereosinophilic syndrome.

A. Fauci, J. Parrillo, 1978, Blood.

Transforming growth factor-&bgr;1 blocks in vitro cardiac myocyte depression induced by tumor necrosis factor-&agr;, interleukin-1&bgr;, and human septic shock serum

Anand Kumar, J. Parrillo, Aseem Kumar, 2007 .

BACTERIAL DNA AND RNA INDUCE RAT CARDIAC MYOCYTE CONTRACTION DEPRESSION IN VITRO

Anand Kumar, J. Parrillo, Aseem Kumar, 2004, Shock.

Probable Kawasaki disease in a 52-year-old man presenting with acute myocardial infarction treated with percutaneous revascularization.

L. Klein, J. Parrillo, D. A. Rivera, 2001, Heart disease.

Cardiac involvement by Kaposi's sarcoma in acquired immune deficiency syndrome (AIDS).

D. Longo, W. Roberts, J. Parrillo, 1984, The American journal of cardiology.

Assessing coronary blood flow dynamics with the TIMI frame count method: Comparison with simultaneous intracoronary Doppler and ultrasound

R. F. Kelly, L. Klein, J. Parrillo, 2001, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Barriers for transradial coronary angiography and interventions in 2016.

J. Parrillo, Pranaychandra Vaidya, Ankitkumar K. Patel, 2017, Cardiovascular revascularization medicine : including molecular interventions.

Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.

C. Natanson, J. Parrillo, M. Fink, 1986, The Journal of clinical investigation.

Our Journal, Critical Care Medicine, in 2005: High impact factor, rapid manuscript review, growing submissions, and widespread distribution

J. Parrillo, 2005, Critical care medicine.

Interleukin-1 gene cluster polymorphisms: all in the family.

Anand Kumar, J. Parrillo, Aseem Kumar, 2002, Critical care medicine.

Genetic factors in septic shock.

Anand Kumar, J. Parrillo, J. Short, 1999, JAMA.

Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest

J. Parrillo, N. Shapiro, S. Trzeciak, 2011, Circulation.

Journal supplements, anemia management, and evidence-based critical care medicine

J. Parrillo, 2001 .

Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.

P. Barie, S. Opal, J. Vincent, 2019, JAMA.

The Relative Influence of Lesion Length and Other Stenosis Morphologies on Procedural Success of Coronary Intervention

L. Klein, J. Parrillo, J. Calvin, 2000, Angiology.

Organization and staffing practices in US cardiac intensive care units: a survey on behalf of the American Heart Association Writing Group on the Evolution of Critical Care Cardiology

C. Granger, D. Morrow, S. Murphy, 2013, European heart journal. Acute cardiovascular care.

Septic shock. Hemodynamics and pathogenesis.

J. Parrillo, M. Parker, 1983, JAMA.

Dilated Cardiomyopathy: Pathogenesis and Treatment

J. Parrillo, 1986 .

Eosinophilic myocarditis.

J. Parrillo, F. Ginsberg, 2005, Heart failure clinics.

Prognostic factors and life expectancy of patients with acquired immunodeficiency syndrome and Pneumocystis carinii pneumonia.

F. Ognibene, J. Shelhamer, A. Fauci, 1987, The American review of respiratory disease.

Admission of AIDS patients to a medical intensive care unit: causes and outcome.

H. Masur, H. Lane, J. Parrillo, 1989, Critical care medicine.

Management of septic shock: present and future.

J. Parrillo, 1991, Annals of internal medicine.

Cardiovascular dysfunction in septic shock.

J. Parrillo, R. Snell, 1991, Chest.

Myocardial function in septic shock

J. Parrillo, M. Parker, 1990 .

Right Ventricular Dysfunction in Critically Ill Patients With COVID-19

Samantha K. Brenner, J. Parrillo, S. Hollenberg, 2022, The American Journal of Cardiology.

Activation of the kallikrein-kinin system after endotoxin administration to normal human volunteers.

R. Colman, J. Parrillo, A. Suffredini, 1993, Blood.

The future of hospital economic health

C. Bekes, J. Parrillo, D. Gerber, 2006, Critical care medicine.

STAT1 and STAT2 Null Cells Are Resistant to RNA-Induced Apoptosis Due to Deficiency in Constitutive and Inducible Apoptosis-Regulating Genes

Anand Kumar, J. Parrillo, Aseem Kumar, 2020, American Journal of Molecular Biology.

Clinical Manifestations of Cardiovascular Dysfunction in Sepsis

Anand Kumar, J. Parrillo, Anand Kumar, 1993 .

Serum neopterin levels following intravenous endotoxin administration to normal humans.

J. Parrillo, A. Suffredini, J. Bloom, 1990, Immunobiology.

Immediate and 1‐Year Survival of Out‐of‐Hospital Cardiac Arrest Victims in Southern New Jersey:

Alan C. Wilson, J. Parrillo, J. Kostis, 2004, Pacing and clinical electrophysiology : PACE.

A Possible Sequelae of Previously Unrecognized Coronary Arterifis in the Adult

J. Parrillo, D. Stephens, Robert E. Dinsinore, 2015 .

Circumflex coronary artery aneurysm visualized by real-time cross-sectional echocardiography. A possible sequelae of previously unrecognized coronary arteritis in the adult.

R. Dinsmore, J. Parrillo, R. Desanctis, 1982, Chest.

RANDOMIZED, BLINDED, PLACEBO‐CONTROLLED TRIAL OF TISSUE FACTOR PATHWAY INHIBITOR IN PORCINE SEPTIC SHOCK

J. Parrillo, G. Trenholme, R. McCarthy, 1998, Shock.

Protein-free phospholipid emulsion treatment improved cardiopulmonary function and survival in porcine sepsis.

J. Parrillo, G. Trenholme, B. Gordon, 2003, American journal of physiology. Regulatory, integrative and comparative physiology.

The diagnosis of Pneumocystis carinii pneumonia in patients with the acquired immunodeficiency syndrome using subsegmental bronchoalveolar lavage.

F. Ognibene, J. Shelhamer, E. Gelmann, 1984, The American review of respiratory disease.

Adult Respiratory Distress Syndrome in Patients with Severe Neutropenia

F. Ognibene, J. Shelhamer, J. Parrillo, 1987 .

The effects of heterologous platelet transfusion on pulmonary function during ARDS.

J. Shelhamer, J. Parrillo, P. Eichacker, 1990, Chest.

Adult respiratory distress syndrome and neutropenia.

F. Ognibene, J. Parrillo, P. Ward, 1987, The New England journal of medicine.

Effect of serum albumin on vascular smooth muscle metabolism.

J. Parrillo, J. T. Barron, E. Rodriguez, 2000, Biochimica et biophysica acta.

Differential effects of fatty acids on glycolysis and glycogen metabolism in vascular smooth muscle.

J. Parrillo, J. T. Barron, S. J. Kopp, 1991, Biochimica et biophysica acta.

Neutralization of endotoxin by a phospholipid emulsion in healthy volunteers.

J. Parrillo, B. Gordon, T. Parker, 2005, The Journal of infectious diseases.

Electrocardiographic abnormalities in mitral valve prolapse.

J. Parrillo, P. Liebson, E. Uretz, 1992, The American journal of cardiology.

Responses of left ventricular function in survivors and nonsurvivors of septic shock

F. Ognibene, J. Shelhamer, C. Natanson, 1989 .

Case report: Vibration response imaging findings following inadvertent esophageal intubation

J. Parrillo, R. Dellinger, S. Jean, 2008, Canadian journal of anaesthesia = Journal canadien d'anesthesie.

Cytoplasmic redox potential affects energetics and contractile reactivity of vascular smooth muscle.

J. Parrillo, J. T. Barron, L. Gu, 1997, Journal of molecular and cellular cardiology.

Severe sepsis and therapy with activated protein C.

J. Parrillo, 2005, The New England journal of medicine.

Cardiovascular effects and safety of intravenous and intramuscular pentamidine isethionate.

K. Bailey, A. Fauci, H. Masur, 1987, Critical Care Medicine.

Intubation of the trachea in the critical care setting.

J. Shelhamer, C. Natanson, J. Parrillo, 1985, JAMA.

Chronic Models of Endotoxemia and Sepsis: Lessons from Both a Canine Peritonitis and a Human Endotoxemia Model

A. C. Dixon, J. Parrillo, 1993 .

Interleukin-10 blunts the human inflammatory response to lipopolysaccharide without affecting the cardiovascular response

J. Parrillo, S. Zanotti, M. Cheang, 2005, Critical care medicine.

Dermatologic manifestations of the hypereosinophilic syndrome.

A. Fauci, J. Parrillo, S. Wolff, 1978, Archives of dermatology.

Induced sputum to diagnose Pneumocystis carinii pneumonia in immunosuppressed pediatric patients.

F. Ognibene, J. Shelhamer, J. Kovacs, 1989, The Journal of pediatrics.

Prevalent myocarditis at necropsy in the acquired immunodeficiency syndrome.

R. Virmani, J. Parrillo, M. Robinowitz, 1988, Journal of the American College of Cardiology.

SEPARATION METHODS, SURFACE MARKERS AND CYTOTOXIC CAPABILITIES OF HUMAN EOSINOPHILS

A. Fauci, J. Parrillo, 1977 .

Protective effect of a novel, potent inhibitor of poly(adenosine 5′-diphosphate-ribose) synthetase in a porcine model of severe bacterial sepsis*

J. Parrillo, É. Szabó, C. Szabó, 2002, Critical care medicine.

Cardiovascular performance with E. coli challenges in a canine model of human sepsis.

C. Natanson, J. Parrillo, R. Danner, 1988, The American journal of physiology.

Comparison of the Effector Cells in Human Spontaneous Cellular Cytotoxicity and Antibody‐Dependent Cellular Cytotoxicity: Differential Sensitivity of Effector Cells to in Vivo and in Vitro Corticosteroids

J. Parrillo, A. S. Fauci, A. Fauci, 1978, Scandinavian journal of immunology.

Simultaneous intracoronary ultrasound and Doppler flow studies distinguish flow‐mediated from receptor‐mediated endothelial responses

L. Klein, J. Parrillo, S. Hollenberg, 1999, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

The critically ill immunosuppressed patient

H. Masur, J. Parrillo, 1987 .

The hypereosinophilic syndrome: dramatic response to therapeutic intervention.

A. Fauci, J. Parrillo, S. Wolff, 1977, Transactions of the Association of American Physicians.

Hemodynamic Profiles of Shock in Patients With COVID-19

T. Glotzer, J. Parrillo, S. Hollenberg, 2021, The American Journal of Cardiology.

Plasma exchange does not improve survival in a canine model of human septic shock

C. Natanson, S. Banks, J. Parrillo, 1993, Transfusion.

Metabolic fate of glucose in vascular smooth muscle during contraction induced by norepinephrine.

M. Bárány, J. Parrillo, J. T. Barron, 1998, Journal of molecular and cellular cardiology.

Oxidation of acetate and octanoate and its relation to glucose metabolism in contracting porcine carotid artery.

M. Bárány, J. Parrillo, J. T. Barron, 1997, Biochimica et biophysica acta.

Monoclonal antibodies to Pneumocystis carinii: identification of specific antigens and characterization of antigenic differences between rat and human isolates.

J. Kovacs, H. Masur, J. Parrillo, 1989, The Journal of infectious diseases.

INTERLEUKIN-2 PRODUCES HEMODYNAMIC CHANGES SIMILAR TO SEPTIC SHOCK IN HUMANS

F. Ognibene, J. Shelhamer, S. Rosenberg, 1986 .

COMPARISON OF STROKE VOLUMES OBTAINED BY ECHOCARDIOGRAPHY AND THERMODILUTION IN SEPTIC PATIENTS

J. Parrillo, S. Hollenberg, A. Neumann, 1994 .

Kaposi's sarcoma causing pulmonary infiltrates and respiratory failure in the acquired immunodeficiency syndrome.

F. Ognibene, J. Shelhamer, L. Liotta, 1985, Annals of internal medicine.

Assessment of Asymmetric Lung Disease in Intensive Care Unit Patients Using Vibration Response Imaging

J. Parrillo, R. Dellinger, S. Jean, 2008, Anesthesia and analgesia.

Sepsis and Myocardial Function

J. Parrillo, M. Parker, 1989 .

Discordant epicardial and microvascular endothelial responses in heart transplant recipients early after transplantation.

L. Klein, J. Parrillo, S. Hollenberg, 1998, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Mechanisms of corticosteroid action on lymphocyte subpopulations. III. Differential effects of dexamethasone administration on subpopulations of effector cells mediating cellular cytotoxicity in man.

A. Fauci, J. Parrillo, 1978, Clinical and experimental immunology.

A Randomized, Double-Blind, Placebo-Controlled, Phase 2b Study to Evaluate the Safety and Efficacy of Recombinant Human Soluble Thrombomodulin, ART-123, in Patients With Sepsis and Suspected Disseminated Intravascular Coagulation*

G. Bernard, J. Vincent, J. Parrillo, 2013, Critical care medicine.

Clinical Characteristics of Patient Groups Patient code Age Sex Underlying disease Positive culture ( site ) Outcome yr cerebral glioblastoma Lymphoma Acute lymphocytic leukemia Mediastinitis ; coronary artery disease Lymphoma Myocardial infarction ; coronary artery disease Lymphoma Chronic granulom

J. Shelhamer, C. Natanson, J. Parrillo, 2013 .

Table L Clinical Characteristics of Patient Groups Patient code Age Sex Underlying disease Positive culture ( site ) Outcome yr cerebral glioblastoma Lymphoma Acute lymphocytic leukemia Mediastinitis ; coronary artery disease Lymphoma Myocardial infarction ; coronary artery disease Lymphoma Chronic

J. Shelhamer, C. Natanson, J. Parrillo, 2013 .

Mediator modulation therapy of severe sepsis and septic shock: does it work?

J. Parrillo, R. Dellinger, R. Phillip Dellinger, 2004, Critical care medicine.

Myocardial dysfunction in septic shock: Part I. Clinical manifestation of cardiovascular dysfunction.

J E Parrillo, J. Parrillo, A. Kumar, 2001, Journal of cardiothoracic and vascular anesthesia.

Myocardial dysfunction in septic shock.

J E Parrillo, Anand Kumar, J. Parrillo, 2000, Critical care clinics.

Infectious Causes of Acute Cardiac Dysfunction

J. Parrillo, R. Cunnion, 1988 .

Profound but reversible myocardial depression in patients with septic shock.

J. Shelhamer, C. Natanson, J. Parrillo, 1984, Annals of internal medicine.

Identification of antigens and antibodies specific for Pneumocystis carinii.

J. Kovacs, H. Masur, J. Parrillo, 1988, Journal of immunology.

MULTICENTER STUDY OF EARLY LACTATE CLEARANCE AS A DETERMINANT OF SURVIVAL IN PATIENTS WITH PRESUMED SEPSIS

J. Parrillo, N. Shapiro, S. Trzeciak, 2008, Shock.

Chapter 24 – Septic Shock

J. Parrillo, S. Trzeciak, R. Dellinger, 2008 .

Vasopressor and inotropic support in septic shock: An evidence-based review

J. Vincent, J. Parrillo, R. Beale, 2004, Critical care medicine.

Septic shock in humans

F. Ognibene, C. Natanson, J. Parrillo, 2020 .

Septic shock in humans. Advances in the understanding of pathogenesis, cardiovascular dysfunction, and therapy.

F. Ognibene, C. Natanson, J. Parrillo, 1990, Annals of internal medicine.

Chapter 22 – Shock: Classification, Pathophysiology, and Approach to Management

J. Parrillo, Joseph E. Parrillo, Anand Kumar, 2008 .

Myocardial Dysfunction in Sepsis and Septic Shock

Anand Kumar, J. Parrillo, Aseem Kumar, 2008 .

Myocardial dysfunction in the patient with sepsis

Anand Kumar, J. Parrillo, Aseem Kumar, 2002, Current opinion in critical care.

Clinical review: Myocardial depression in sepsis and septic shock

Anand Kumar, J. Parrillo, Aseem Kumar, 2002, Critical care.

Endotoxin and tumor necrosis factor challenges in dogs simulate the cardiovascular profile of human septic shock

C. Natanson, S. Banks, J. Parrillo, 1989, The Journal of experimental medicine.

Serial cardiovascular variables in survivors and nonsurvivors of human septic shock: heart rate as an early predictor of prognosis.

J E Parrillo, J. Shelhamer, D. Alling, 1987, Critical care medicine.

Characterization of de novo folate synthesis in Pneumocystis carinii and Toxoplasma gondii: potential for screening therapeutic agents.

J. Kovacs, H. Masur, J. Parrillo, 1989, The Journal of infectious diseases.

Death in the AIDS patient: role of cytomegalovirus.

D. Longo, A. Fauci, H. Lane, 1983, The New England journal of medicine.

Nitric oxide synthase inhibition reverses arteriolar hyporesponsiveness to endothelin-1 in septic rats.

J. Parrillo, S. Hollenberg, M. Piotrowski, 1993, The American journal of physiology.

Acute kidney injury in septic shock: clinical outcomes and impact of duration of hypotension prior to initiation of antimicrobial therapy

S. Bagshaw, S. Lapinsky, Anand Kumar, 2009, Intensive Care Medicine.

Diagnosis of Pneumocystis carinii pneumonia: improved detection in sputum with use of monoclonal antibodies.

J E Parrillo, F. Ognibene, J. Shelhamer, 1988, The New England journal of medicine.

Detection of Pneumocystis carinii by fluorescent-antibody stain using a combination of three monoclonal antibodies

J. Kovacs, H. Masur, J. Parrillo, 1987, Journal of clinical microbiology.

Potent effect of trimetrexate, a lipid-soluble antifolate, on Toxoplasma gondii.

J. Kovacs, H. Masur, J. Parrillo, 1987, The Journal of infectious diseases.

laboratory and animal investigations Pseudomonas aeruginosa Compared with Escherichia coil Produces Less Endotoxemia but More Cardiovascular Dysfunction and Mortality in a Canine Model of Septic Shock *

J. Parrillo, R. Danner, J. Hosseini, 2006 .

Pseudomonas aeruginosa compared with Escherichia coli produces less endotoxemia but more cardiovascular dysfunction and mortality in a canine model of septic shock.

C. Natanson, S. Banks, J. Parrillo, 1990, Chest.

Bioavailability of oral trimetrexate in patients with acquired immunodeficiency syndrome

H. Masur, H. Lane, J. Parrillo, 1988, Antimicrobial Agents and Chemotherapy.

Initiation of inappropriate antimicrobial therapy results in a fivefold reduction of survival in human septic shock.

Anand Kumar, D. Roberts, B. Light, 2009, Chest.

Chapter 26 – Severe Sepsis and Multiple Organ Dysfunction

J. Parrillo, S. Zanotti-Cavazzoni, R. Dellinger, 2008 .

Early microcirculatory perfusion derangements in patients with severe sepsis and septic shock: relationship to hemodynamics, oxygen transport, and survival.

Jasmeet Bajaj, J. Parrillo, S. Zanotti, 2007, Annals of emergency medicine.

Agranulocytosis following infectious mononucleosis.

J. Parrillo, N. Hadler, B. Koziner, 1973, JAMA.

Endocarditis due to resistant viridans streptococci during oral penicillin chemoprophylaxis.

J. Parrillo, M. Klempner, R. Moellering, 1979, The New England journal of medicine.

Arterial, central venous and pulmonary artery catheters

J. Vincent, J. Parrillo, R. Dellinger, 2008 .

Purification, toxicity, and antiendotoxin activity of polymyxin B nonapeptide

K. Joiner, J. Parrillo, R. Danner, 1989, Antimicrobial Agents and Chemotherapy.

Multiple Organ Dysfunction After Return of Spontaneous Circulation in Postcardiac Arrest Syndrome

J. Parrillo, S. Trzeciak, B. Roberts, 2013, Critical care medicine.

Apparent direct cellular cytotoxicity mediated via cytophilic antibody. Multiple Fc receptor bearing effector cell populations mediating cytophilic antibody induced cytotoxicity.

A. Fauci, J. Parrillo, 1977, Immunology.

Inhibition of lymphocyte transformation by a placental glycoprotein.

J. Parrillo, R. Riggio, A. Rubin, 1971, Transplantation.

Critical Care Medicine

J E Parrillo, J. Parrillo, S. Hollenberg, 2015 .

Erysipelothrix rhusiopathiae bacteremia presenting as septic shock.

F. Ognibene, A. Fauci, J. Parrillo, 1985, The American journal of medicine.

Activation of phosphatidylinositol turnover in rat aorta by α1-adrenergic receptor stimulation

B. Roth, J. Parrillo, B. Chernow, 1985 .

Characterization of the direct effects of cyclophosphamide on cell-mediated immunological responses.

A. Fauci, J. Parrillo, J. Balow, 1977, Immunology.

Sepsis and septic shock: a history.

Anand Kumar, J. Parrillo, D. Funk, 2009, Critical care clinics.

Characterization of human septic sera induced gene expression modulation in human myocytes.

J. Parrillo, Aseem Kumar, K. Passi, 2009, International journal of clinical and experimental medicine.

Pulmonary artery occlusion pressure and central venous pressure fail to predict ventricular filling volume, cardiac performance, or the response to volume infusion in normal subjects

Clifford Kavinsky, J. Parrillo, S. Zanotti, 2004, Critical care medicine.

Indolent epidemic of Pseudomonas cepacia bacteremia and pseudobacteremia in an intensive care unit traced to a contaminated blood gas analyzer.

J. Parrillo, D. Henderson, V. Gill, 1988, The American journal of medicine.

Septic sera induces apoptosis and DNA fragmentation factor 40 activation in fibroblasts.

J. Parrillo, Aseem Kumar, C. Ramana, 2011, Biochemical and biophysical research communications.

ELEVATED C5A LEVELS IN PATIENTS WITH SEPTIC SHOCK

F. Ognibene, J. Shelhamer, C. Natanson, 1985 .

Early increases in microcirculatory perfusion during protocol-directed resuscitation are associated with reduced multi-organ failure at 24 h in patients with sepsis

J. Parrillo, N. Shapiro, S. Trzeciak, 2008, Intensive Care Medicine.

The duration of hypotension before the initiation of antibiotic treatment is a critical determinant of survival in a murine model of Escherichia coli septic shock: association with serum lactate and inflammatory cytokine levels.

S. Opal, J. Parrillo, Leo Taiberg, 2006, The Journal of infectious diseases.

Therapeutic trial of lipid X in a canine model of septic shock.

C. Natanson, M. Doerfler, J. Parrillo, 1993, The Journal of infectious diseases.

Prognostic factors in sepsis: The cold facts

J. Parrillo, R. Balk, 1992, Critical care medicine.

Therapy of the hypereosinophilic syndrome.

A. Fauci, J. Parrillo, S. Wolff, 1978, Annals of internal medicine.

Pathophysiology and Natural History the Coronary Circulation in Human Septic Shock

C. Natanson, J. Parrillo, M. Parker, 2022 .

The coronary circulation in human septic shock.

C. Natanson, J. Parrillo, M. Parker, 1986, Circulation.

Effects of nitric oxide synthase inhibition on microvascular reactivity in septic mice.

J. Parrillo, S. Hollenberg, C. Easington, 1999, Shock.

PORCINE MODELS OF SEVERE SEPSIS: EMPHASIS ON PORCINE PERITONITIS

J. Parrillo, R. Dellinger, R. Goldfarb, 2005, Shock.

Neutrophil aggregating activity and septic shock in humans: Neutrophil aggregation by a C5a-like material occurs more frequently than complement component depletion and correlates with depression of systemic vascular resistance

F. Ognibene, J. Shelhamer, C. Natanson, 1988 .

Pulmonary and oxygen transport effects of intravenously administered endotoxin in normal humans.

J. Shelhamer, J. Parrillo, A. Suffredini, 1992, The American review of respiratory disease.

Pulmonary Artery Catheter Consensus conference: consensus statement.

C. Sprung, L. Nelson, G. Bernard, 1997, Critical care medicine.

Critical Care Medicine: Principles of Diagnosis and Management

J. Parrillo, R. Bone, 1995 .

Resuscitating the microcirculation in sepsis: the central role of nitric oxide, emerging concepts for novel therapies, and challenges for clinical trials.

J. Parrillo, N. Shapiro, S. Trzeciak, 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

Reversible myocardial dysfunction: an ubiquitous phenomenon in the critically ill?

Anand Kumar, J. Parrillo, Aseem Kumar, 2002, Critical care medicine.

Association between arterial hyperoxia following resuscitation from cardiac arrest and in-hospital mortality.

D. Angus, J. Parrillo, N. Shapiro, 2010, JAMA.

Tumor necrosis factor alpha and interleukin 1beta are responsible for in vitro myocardial cell depression induced by human septic shock serum

Anand Kumar, J. Parrillo, E. Uretz, 1996, The Journal of experimental medicine.

A PORCINE MODEL OF PERITONITIS AND BACTEREMIA SIMULATES HUMAN SEPTIC SHOCK

Anand Kumar, J. Parrillo, G. Trenholme, 1996, Shock.

Critical care in the United States. Who are we and how did we get here?

J. Parrillo, J. Calvin, Kalim J. Habet, 1997, Critical care clinics.

Effect of septic serum on vascular smooth muscle: In vitro studies using rat aortic rings

J. Parrillo, S. Hollenberg, ROBERT E. CUNNION, 1992, Critical care medicine.

Hemodynamic effects of dopamine, norepinephrine, and fluids in a dog model of sepsis.

C. Natanson, S. Banks, J. Parrillo, 1995, The American journal of physiology.

Factors that determine the hemodynamic response to inhalation anesthetics.

D. Alling, C. Natanson, S. Banks, 1991, Journal of applied physiology.

Dopamine inhibition of histamine-mediated cutaneous responses.

J. Shelhamer, T. Casale, M. Kaliner, 1984, The Journal of allergy and clinical immunology.

Depressed left ventricular performance. Response to volume infusion in patients with sepsis and septic shock.

F. Ognibene, J. Shelhamer, C. Natanson, 1988, Chest.

Randomized Controlled Trial of Inhaled Nitric Oxide for the Treatment of Microcirculatory Dysfunction in Patients With Sepsis*

J. Parrillo, S. Trzeciak, R. Dellinger, 2014, Critical care medicine.

Objectives: Sepsis treatment guidelines recommend macrocircu- latory hemodynamic optimization; however, microcirculatory dys- function is integral to sepsis pathogenesis. We aimed to test the hypothesis that following macrocirculatory optimization, inhaled nitric oxide would improve microcirculation

J. Parrillo, S. Trzeciak, R. Dellinger, 2014 .

Ventricular dilation is associated with improved cardiovascular performance and survival in sepsis.

J. Parrillo, R. Dellinger, S. Hollenberg, 2010, Chest.

Increased microvascular reactivity and improved mortality in septic mice lacking inducible nitric oxide synthase.

J. Parrillo, S. Hollenberg, J. Osman, 2000, Circulation research.

Role of endotoxemia in cardiovascular dysfunction and mortality. Escherichia coli and Staphylococcus aureus challenges in a canine model of human septic shock.

C. Natanson, S. Banks, J. Parrillo, 1989, The Journal of clinical investigation.

BACTERIAL SHOCK AND MYOCARDIAL FUNCTION H 559 Clot Implantation into Comprehensive Evaluation CE ' Peritoneum CE ' CE '

C. Natanson, J. Parrillo, R. Danner, 2022 .

Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility.

J. Parrillo, A. Kumar, R. Schulz, 1999, The American journal of physiology.

Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility.

Anand Kumar, J. Parrillo, R. Schulz, 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

Chronic granulomatous disease. Diagnosis in a 27-year-old man with Mycobacterium fortuitum.

A. Fauci, J. Parrillo, M. Chusid, 1975, JAMA.

The role of immunostimulatory nucleic acids in septic shock.

J. Parrillo, Aseem Kumar, C. Ramana, 2012, International journal of clinical and experimental medicine.

Angiotensin converting enzyme inhibitors in bone marrow transplant recipients with depressed left ventricular function.

J. Parrillo, R. Ghalie, J. T. Barron, 1995, Bone marrow transplantation.

Chapter 23 – Treatment of Ventricular Tachycardia and Cardiac Arrest

A. Russo, J. Parrillo, S. Trzeciak, 2013 .

Significance of arterial hypotension after resuscitation from cardiac arrest*

J. Parrillo, N. Shapiro, S. Trzeciak, 2009, Critical care medicine.

Direct current cardioversion: indications, techniques, and recent advances.

J. Parrillo, R. Trohman, 2000, Critical care medicine.

Unstable angina and non-Q wave myocardial infarction: does the clinical diagnosis have therapeutic implications?

L. Klein, J. Parrillo, J. Calvin, 1999, Journal of the American College of Cardiology.

Chapter 23 – Cardiogenic Shock

J. Parrillo, S. Hollenberg, 2008 .

Cardiogenic Shock

J. Parrillo, S. Hollenberg, C. Kavinsky, 1971, Journal of the American Heart Association.

Culture-Negative Septic Shock Compared With Culture-Positive Septic Shock: A Retrospective Cohort Study

J. Parrillo, Aseem Kumar, H. Kirchner, 2018, Critical care medicine.

Inhibition of endotoxin-induced priming of human neutrophils by lipid X and 3-Aza-lipid X.

K. Joiner, J. Parrillo, R. Danner, 1987, The Journal of clinical investigation.

A prospective multicenter cohort study of the association between global tissue hypoxia and coagulation abnormalities during early sepsis resuscitation

J. Parrillo, N. Shapiro, S. Trzeciak, 2010, Critical care medicine.

Clinical characteristics, sepsis interventions and outcomes in the obese patients with septic shock: an international multicenter cohort study

Daniel Feinstein, Kenneth E Wood, K. Wood, 2013, Critical Care.

Cardiorespiratory effects of immunotherapy with interleukin-2.

F. Ognibene, J. Shelhamer, R. Bonow, 1989, Journal of clinical oncology : official journal of the American Society of Clinical Oncology.

Pathogenesis of Cardiovascular Dysfunction in Septic Shock

J. Parrillo, 1989 .

Mycobacterium tuberculosis septic shock.

S. Lapinsky, Anand Kumar, J. Parrillo, 2013, Chest.

Early combination antibiotic therapy yields improved survival compared with monotherapy in septic shock: A propensity-matched analysis*

S. Lapinsky, Anand Kumar, B. Light, 2010, Critical care medicine.

Improved Early Detection of Sepsis in the ED With a Novel Monocyte Distribution Width Biomarker

C. Seymour, D. Angus, J. Parrillo, 2017, Chest.

Monocyte Distribution Width: A Novel Indicator of Sepsis-2 and Sepsis-3 in High-Risk Emergency Department Patients*

C. Seymour, D. Angus, J. Parrillo, 2019, Critical care medicine.

Monocyte distribution width enhances early sepsis detection in the emergency department beyond SIRS and qSOFA

David T. Huang, G. Martin, J. Parrillo, 2020, Journal of Intensive Care.

Chapter 30 – Severe Heart Failure

J. Parrillo, F. Ginsberg, 2008 .

Severe Heart Failure in the ICU

J. Parrillo, F. Ginsberg, 2005 .

Bacterial lipopolysaccharides prime human neutrophils for enhanced production of leukotriene B4.

J. Shelhamer, M. Doerfler, J. Parrillo, 1989, The Journal of clinical investigation.

Validated risk stratification model accurately predicts low risk in patients with unstable angina.

L. Klein, J. Parrillo, J. Calvin, 1998, Journal of the American College of Cardiology.

Frequency of abrupt vessel closure and side branch occlusion after percutaneous coronary intervention in a 6.5-year period (1994 to 2000) at a single medical center.

L. Klein, J. Parrillo, J. Calvin, 2002, The American journal of cardiology.

Risk stratification post-myocardial infarction: is early coronary angiography the more effective strategy?

L. Klein, J. Parrillo, J. Forrester, 2002, Progress in cardiovascular diseases.

Clinical predictors easily obtained at presentation predict resource utilization in unstable angina.

L. Klein, J. Parrillo, J. Calvin, 1998, American heart journal.

Does low individual operator coronary interventional procedural volume correlate with worse institutional procedural outcome?

L. Klein, J. Parrillo, J. Calvin, 1997, Journal of the American College of Cardiology.

Emergency department inter-hospital transfer for post-cardiac arrest care: initial experience with implementation of a regional cardiac resuscitation center in the United States.

J. Parrillo, S. Zanotti, S. Trzeciak, 2013, Resuscitation.

Evolution of critical care cardiology: transformation of the cardiovascular intensive care unit and the emerging need for new medical staffing and training models: a scientific statement from the American Heart Association.

C. Granger, D. Morrow, J. López-Sendón, 2012, Circulation.

Risk stratification in unstable angina. Prospective validation of the Braunwald classification.

L. Klein, J. Parrillo, J. Calvin, 1995, JAMA.

Unresponsiveness of Legionella bozemanii pneumonia to erythromycin administration despite in vitro sensitivity.

J. Shelhamer, J. Parrillo, A. Macher, 1983, The American review of respiratory disease.

Utility of history, physical examination, electrocardiogram, and chest radiograph for differentiating normal from decreased systolic function in patients with heart failure.

R. F. Kelly, J. Parrillo, J. Calvin, 2002, The American journal of medicine.

Fluid resuscitation influences cardiovascular performance and mortality in a murine model of sepsis

J. Parrillo, R. Dellinger, R. Dellinger, 2009, Intensive Care Medicine.

Alternative therapeutic strategies for patients with severe end‐stage coronary artery disease not amenable to conventional revascularization

L. Klein, J. Parrillo, F. Almeda, 2003, Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions.

Survival in Human Septic Shock Therapy Results in a Fivefold Reduction of Initiation of Inappropriate Antimicrobial

D. Roberts, B. Light, J. Parrillo, 2009 .

Septic shock--vasopressin, norepinephrine, and urgency.

J. Parrillo, Joseph E Parrillo, 2008, The New England journal of medicine.

Human Serum from Patients with Septic Shock Activates Transcription Factors STAT1, IRF1, and NF-κB and Induces Apoptosis in Human Cardiac Myocytes*

J. Parrillo, Aseem Kumar, C. Ramana, 2005, Journal of Biological Chemistry.

Impaired microvascular vasoconstrictive responses to vasopressin in septic rats.

J. Parrillo, S. Hollenberg, C. Easington, 1997, Critical care medicine.

Ocular permeability after systemic administration of endotoxin in humans.

J. Parrillo, A. Palestine, D. Herman, 1991, Current eye research.

The cardiovascular pathophysiology of sepsis.

J E Parrillo, J. Parrillo, Joseph E. Parrillo, 1989, Annual review of medicine.

Association between height and coronary artery disease in black men and women.

R. F. Kelly, J. Parrillo, A. Hashim, 2000, The American journal of cardiology.

Cardiogenic shock: a historical perspective.

J. Parrillo, F. Ginsberg, 2009, Critical care clinics.

Hypotension, acidosis, and vasodilatation syndrome post-heart transplant: prognostic variables and outcomes.

J. Parrillo, M. Costanzo, P. Meyer, 2001, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

A prospective, randomized, controlled trial of prednisone for dilated cardiomyopathy.

J E Parrillo, D. Alling, V. Ferrans, 1989, The New England journal of medicine.

The effect of percutaneous transmyocardial laser revascularization on left ventricular function in a porcine model of hibernating myocardium: a pilot study.

J. Parrillo, G. Schaer, F. Almeda, 2004, Cardiovascular radiation medicine.

Nitric oxide-dependent and -independent mechanisms are involved in TNF-alpha -induced depression of cardiac myocyte contractility.

Anand Kumar, J. Parrillo, Aseem Kumar, 2007, American journal of physiology. Regulatory, integrative and comparative physiology.

Blood histamine concentrations are not elevated in humans with septic shock.

J. Shelhamer, M. Kaliner, J. Parrillo, 1989, Critical care medicine.

Antimicrobial therapeutic determinants of outcomes from septic shock among patients with cirrhosis

Z. Memish, S. Lapinsky, Anand Kumar, 2012, Hepatology.

Timing of vasopressor initiation and mortality in septic shock: a cohort study

Anand Kumar, J. Parrillo, S. Zanotti, 2014, Critical Care.

Biphasic intra-thoracic pressure regulation augments cardiac index during porcine peritonitis: a feasibility study

J. Parrillo, A. Metzger, K. Lurie, 2014, Journal of medical engineering & technology.

Echocardiography for hemodynamic assessment of patients with advanced heart failure and potential heart transplant recipients.

J. Parrillo, J. Stein, M. Costanzo, 1997, Journal of the American College of Cardiology.

Clinical practice guidelines in unstable angina improve clinical outcomes by assuring early intensive medical treatment.

L. Klein, J. Parrillo, J. Calvin, 1999, Journal of the American College of Cardiology.

Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility study.

J. Parrillo, S. Trzeciak, R. Dellinger, 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

Flow panel reactive antibody monitoring following heart transplantation.

J. Parrillo, M. Costanzo, A. Tambur, 2001, Transplantation proceedings.

The pathophysiology of septic shock.

J. Parrillo, O. Nduka, O. Okorie Nduka, 2011, Critical care nursing clinics of North America.

The pathophysiology of septic shock.

J. Parrillo, O. Nduka, O. Okorie Nduka, 2009, Critical care clinics.

JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR.

J. Parrillo, Aseem Kumar, C. Ramana, 2013, International journal of clinical and experimental medicine.

Cardiovascular dysfunction in sepsis and septic shock

Anand Kumar, J. Parrillo, Michael J. Landgarten, 2000, Current treatment options in cardiovascular medicine.

TRANFORMING GROWTH FACTOR (TGF)-beta INHIBITS HUMAN SEPTIC SERUM-INDUCED DEPRESSION OF CARDIAC MYOCYTE CONTRACTILITY

J. Parrillo, Aseem Kumar, Amit Kumar, 1999 .

THE CARDIOVASCULAR RESPONSE TO INCREMENTAL DOSES OF DOBUTAMINE IN SEPTIC SHOCK: PREDICTION OF SURVIVAL

Anand Kumar, J. Parrillo, J. Calvin, 1994 .

THE CARDIOVASCULAR RESPONSE TO INCREMENTAL DOSES OF DOBUTAMINE IN SEPTIC SHOCK: MECHANISM OF HEMOD YNAMIC RESPONSE

Anand Kumar, J. Parrillo, J. Calvin, 1994 .

MYOCARDIAL CELL CONTRACTILITY IS DEPRESSED BY SUPERNATANTS OF ENDOTOXIN STIMULATED THP-1 CELLS

Anand Kumar, J. Parrillo, L. Casey, 1994 .

Closed loop television tracking of beating heart cells in vitro.

W H Schuette, C Burch, P O Roach, 1987, Cytometry.

REVERSIBLE DEPRESSION AND VENTRICULAR DILATATION DEMONSTRATED BY TWO DIMENSIONAL ECHOCARDIOGRAPHY IN HUMANS WITH SEPTIC SHOCK

J. Parrillo, M. Parker, R. Cunnion, 1986 .

Efficacy of trimetrexate, a potent lipid-soluble antifolate, in the treatment of rodent Pneumocystis carinii pneumonia.

J. Kovacs, H. Masur, J. Parrillo, 1988, The American journal of tropical medicine and hygiene.

Effectiveness of chart prompts to improve physician compliance with the National Cholesterol Education Program guidelines.

J. Parrillo, J. Calvin, T. Stamos, 2001, The American journal of cardiology.

Inclusion criteria for clinical trials in sepsis: did the American College of Chest Physicians/Society of Critical Care Medicine consensus conference definitions of sepsis have an impact?

J. Parrillo, S. Trzeciak, R. Dellinger, 2005, Chest.

Clinical characteristics and outcomes of septic patients with new-onset atrial fibrillation.

J. Parrillo, C. Schorr, D. Gerber, 2008, Journal of critical care.

Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury.

J. Parrillo, Aseem Kumar, L. Tamer, 2012, Journal of thoracic disease.

Image‐based monitoring of one‐lung ventilation

J. Parrillo, R. Dellinger, S. Jean, 2008, European journal of anaesthesiology.

Regional distribution of acoustic-based lung vibration as a function of mechanical ventilation mode

Yael A. Glickman, J. Parrillo, R. Dellinger, 2007, Critical care.

THE ROLE OF VIBRATION RESPONSE IMAGING IN THE TITRATION OF PEEP IN A MECHANICALLY VENTILATED PATIENT WITH ACUTE RESPIRATORY DISTRESS SYNDROME.: 608

J. Parrillo, R. Dellinger, S. Jean, 2006 .

Assessment of the effectiveness of lung recruitment and PEEP setting by vibration response imaging

J. Parrillo, S. Jean, I. Cinel, 2006, Critical Care.

Cardiac myocyte differentiation induced by 3,5,3'-triiodo-L-thyronine (T3) in P19 teratocarcinoma cells is accompanied by preferential binding of RGG(T/A)CA direct repeats spaced by 4 base pairs in the DNA.

J. Parrillo, E. Rodriguez, U. S. Onwuta, 1994, Biochemical and biophysical research communications.

Interaction Between Fluids and Vasoactive Agents on Mortality in Septic Shock: A Multicenter, Observational Study*

Stephen E. Lapinsky, John Marshall, Yaseen Arabi, 2014, Critical care medicine.

Production of lactic acid and energy metabolism in vascular smooth muscle: effect of dichloroacetate.

J. Parrillo, J. T. Barron, 1995, The American journal of physiology.

Endothelial- and nitric oxide-dependent effects on oxidative metabolism of intact artery.

J. Parrillo, J. T. Barron, L. Gu, 2001, Biochimica et biophysica acta.

Reversible causes of severe myocardial dysfunction.

J. Parrillo, S. Hollenberg, 1997, The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.

Examination of the enzyme assay for NADPH oxidoreductase; application to polymorphonuclear leukocyte superoxide anion generation.

J. Shelhamer, J. Parrillo, J. Zimmerman, 1985, Critical care medicine.

Circulating substances and energy metabolism in septic shock.

K. Wood, Anand Kumar, J. Parrillo, 2003, Critical care medicine.

Activation of phosphatidylinositol turnover in rat aorta by alpha 1-adrenergic receptor stimulation.

B. Roth, J. Parrillo, B. Chernow, 1985, European Journal of Pharmacology.

Critical Care Medicine: Principles of Diagnosis and Management in the Adult

J. Parrillo, R. Dellinger, R. Phillip Dellinger, 2001 .

Point-of-care assessment of microvascular blood flow in critically ill patients

J. Parrillo, N. Shapiro, S. Trzeciak, 2009, Intensive Care Medicine.

O R I G I N A L A R T I C L E Involvement of Rho kinase (ROCK) in sepsis-induced acute lung injury

Anand Kumar, J. Parrillo, Aseem Kumar, 2011 .

From the bench to the bedside: The future of sepsis research - Executive summary of an American College of Chest Physicians, National Institute of Allergy and Infectious Disease, and National Heart, Lung, and Blood Institute Workshop

S. Hurd, D. Teres, G. Bernard, 1997 .

Fifty Years of Critical Care Medicine: The Editors' Perspective.

P. Kochanek, J. Parrillo, T. Buchman, 2022, Critical care medicine.

DEPRESSED VENTRICULAR PERFORMANCE IN RESPONSE TO VOLUME INFUSION IN PATIENTS WITH SEPTIC SHOCK

F. Ognibene, J. Shelhamer, C. Natanson, 1986 .

Transfusion of packed red blood cells is not associated with improved central venous oxygen saturation or organ function in patients with septic shock.

J. Parrillo, S. Zanotti, R. Dellinger, 2012, The Journal of emergency medicine.

Continuous cardiac index monitoring: A prospective observational study of agreement between a pulmonary artery catheter and a calibrated minimally invasive technique.

J. Parrillo, S. Trzeciak, R. Arnold, 2009, Resuscitation.

INFECTIONS DUE TO PNEUMOCYSTIS CARINII AND MYCOBACTERIUM AVIUM‐INTRACELLULARE IN PATIENTS WITH ACQUIRED IMMUNE DEFICIENCY SYNDROME

J. Kovacs, H. Masur, J. Parrillo, 1984, Annals of the New York Academy of Sciences.

Critical care medicine as a distinct product line with substantial financial profitability: The role of business planning

Robert Edmondson, C. Bekes, J. Parrillo, 2004, Critical care medicine.

Abnormal ECG in man admitted to ICU with chest pain and irregular pulse.

J. Parrillo, 2004, Chest.

The management of pneumonias in immunocompromised patients.

J. Shelhamer, H. Masur, J. Parrillo, 1985, JAMA.

Early arterial hypotension is common in the post-cardiac arrest syndrome and associated with increased in-hospital mortality.

J. Parrillo, S. Trzeciak, R. Dellinger, 2008, Resuscitation.

How well does radionuclide dipyridamole stress testing detect three-vessel coronary artery disease and ischemia in the region supplied by the most stenotic vessel?

J. Parrillo, J. T. Barron, A. Ali, 1999, Clinical nuclear medicine.

The impact of packed red blood cell transfusion on clinical outcomes in patients with septic shock treated with early goal directed therapy

J. Parrillo, S. Zanotti, R. Dellinger, 2010, Indian journal of critical care medicine : peer-reviewed, official publication of Indian Society of Critical Care Medicine.

Other Mediator Systems Complement

J. Parrillo, R. Goldfarb, 2005 .

Cardiovascular response to dobutamine stress predicts outcome in severe sepsis and septic shock

Anand Kumar, J. Parrillo, B. Milcarek, 2008, Critical care.

Cardiovascular Dysfunction in Humans with Septic Shock

J. Parrillo, 1986 .

F. Ognibene, J. Parrillo, M. Parker, 1988 .

Major issues in critical care medicine

J. Parrillo, S. Ayres, 1984 .

Cloning and Characterization of the Human Heparanase-1 (HPR1) Gene Promoter ROLE OF GA-BINDING PROTEIN AND Sp1 IN REGULATING HPR1 BASAL PROMOTER ACTIVITY*

J. Parrillo, Aseem Kumar, J. Platt, 2002 .

Discordance between microcirculatory alterations and arterial pressure in patients with hemodynamic instability.

J. Parrillo, N. Shapiro, S. Trzeciak, 2012, Journal of critical care.

ENDOTOXEMIA IN HUMAN SEPTIC SHOCK

J. Parrillo, R. Danner, R. Elin, 1988 .

Renal hemodynamics and prostaglandin E2 excretion in a nonhuman primate model of septic shock

J. Parrillo, M. Fink, B. Chernow, 1990, Critical care medicine.

Malate-aspartate shuttle, cytoplasmic NADH redox potential, and energetics in vascular smooth muscle.

J E Parrillo, J. Parrillo, J T Barron, 1998, Journal of molecular and cellular cardiology.

Transforming growth factor-beta1 blocks in vitro cardiac myocyte depression induced by tumor necrosis factor-alpha, interleukin-1beta, and human septic shock serum.

Anand Kumar, J. Parrillo, Aseem Kumar, 2007, Critical care medicine.

CARING FOR THE CRITICALLY ILL PATIENT Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality

J. Parrillo, N. Shapiro, S. Trzeciak, 2010 .

Cryptococcosis in the acquired immunodeficiency syndrome.

E. Gelmann, A. Fauci, J. Kovacs, 1985, Annals of internal medicine.

Effects of clinical maneuvers on sonographically determined internal jugular vein size during venous cannulation.

T. Shawker, J. Parrillo, W. McGee, 1990, Critical care medicine.

Severe Pneumocystis carinii pneumonia produces a hyperdynamic profile similar to bacterial pneumonia with sepsis

F. Ognibene, J. Shelhamer, H. Masur, 1994, Critical Care Medicine.

Myocardial dysfunction in sepsis.

J. Parrillo, R. Cunnion, 1989, Critical care clinics.

Herpesvirus infections in the acquired immune deficiency syndrome.

H. Masur, J. Parrillo, M. Parker, 1984, JAMA.

DURATION OF SHOCK PRIOR TO ANTIMICROBIAL ADMINISTRATION IS THE CRITICAL DETERMINANT OF SURVIVAL IN HUMAN SEPTIC SHOCK: 41

K. Wood, Anand Kumar, D. Roberts, 2004 .

EMERGENCY OPEN LUNG BIOPSY AT NIH: USE OF A NEW MODIFIED METHYLENE BLUE STAIN FOR THE RAPID TISSUE DEMONSTRATION OF LEGIONELLA, PNEUMOCYSTIS, CYTOMEGALOVIRUS, NOCARDIA AND FUNGI CAUSING OPPORTUNISTIC PNEUMONIAS

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TAKEDA-143242 increased survival via reduced cytokines in porcine peritonitis.

J. Parrillo, R. Dellinger, L. Casey, 2011, The Journal of surgical research.

A CYTOKINE PRODUCTION INHIBITOR (TAK-242) IMPROVES CARDIOVASCULAR PERFORMANCE, INHIBITS CYTOKINE RELEASE AND INCREASES SURVIVAL IN A PORCINE MODEL OF GRAM-NEGATIVE SEPSIS: 59

J. Parrillo, R. Dellinger, G. Trenholme, 2004 .

Research in critical care medicine: Present status of critical care investigation

J. Parrillo, 1991, Critical care medicine.

Outcome measures utilized in clinical trials of interventions for post-cardiac arrest syndrome: a systematic review.

J. Parrillo, S. Trzeciak, B. Fuller, 2009, Resuscitation.

Role of nitric oxide and cGMP in human septic serum-induced depression of cardiac myocyte contractility.

J. Parrillo, R. Schulz, R. Brar, 1999, American journal of physiology. Regulatory, integrative and comparative physiology.

CIRCULATING TUMOR NECROSIS FACTOR IN NORMAL VOLUNTEERS RECEIVING ENDOTOXIN

J. Kovacs, J. Parrillo, R. Fromm, 1988 .

Surviving Sepsis Campaign guidelines for management of severe sepsis and septic shock

C. Sprung, S. Opal, J. Carcillo, 2004, Intensive Care Medicine.

The Cardiovascular Patho Physiology Of Sepsis

J. Parrillo, J. Parrillo, 1989 .

Relationship Between Supranormal Oxygen Tension and Outcome After Resuscitation From Cardiac Arrest

J. Parrillo, S. Trzeciak, B. Milcarek, 2011, Circulation.

Barriers for transradial coronary angiography and interventions in 2016.

J. Parrillo, Pranaychandra Vaidya, Ankitkumar K. Patel, 2017, Cardiovascular revascularization medicine : including molecular interventions.

CARING FOR THE CRITICALLY ILL PATIENT Association Between Arterial Hyperoxia Following Resuscitation From Cardiac Arrest and In-Hospital Mortality

J. Parrillo, N. Shapiro, S. Trzeciak, 2010 .

Use of a standardized order set for achieving target temperature in the implementation of therapeutic hypothermia after cardiac arrest: a feasibility study.

J. Parrillo, S. Trzeciak, R. Dellinger, 2008, Academic emergency medicine : official journal of the Society for Academic Emergency Medicine.

Multiple Organ Dysfunction After Return of Spontaneous Circulation in Postcardiac Arrest Syndrome

J. Parrillo, S. Trzeciak, B. Roberts, 2013, Critical care medicine.

Coronary Endothelial Dysfunction After Heart Transplantation Predicts Allograft Vasculopathy and Cardiac Death

L. Klein, J. Parrillo, S. Hollenberg, 2002, Circulation.

Chapter 23 – Cardiogenic Shock

J. Parrillo, S. Hollenberg, 2008 .

Right ventricular dysfunction and dilatation, similar to left ventricular changes, characterize the cardiac depression of septic shock in humans.

F. Ognibene, J. Parrillo, M. Parker, 1990, Chest.

Electrocardiographic diagnosis of acute myocardial infarction: Current concepts for the clinician.

J. Parrillo, Y. Birnbaum, E. Sgarbossa, 2001, American heart journal.