N. Vermeulen

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Molecular dynamics simulations and free energy calculations on the enzyme 4‐hydroxyphenylpyruvate dioxygenase

Chris Oostenbrink, Nico P. E. Vermeulen, Alice Glättli, 2011, J. Comput. Chem..

Biomarkers of free radical damage applications in experimental animals and in humans.

N. Vermeulen, J. Meerman, J. Commandeur, 1999, Free radical biology & medicine.

The role of water molecules in computational drug design.

N. Vermeulen, C. Oostenbrink, Stephanie B. A. de Beer, 2010, Current topics in medicinal chemistry.

Evaluation of alkoxyresorufins as fluorescent substrates for cytochrome P450 BM3 and site-directed mutants.

N. Vermeulen, J. Commandeur, B. Lussenburg, 2005, Analytical biochemistry.

Application of a Fluorescence-Based Continuous-Flow Bioassay to Screen for Diversity of Cytochrome P450 BM3 Mutant Libraries

N. Vermeulen, J. Commandeur, J. Reinen, 2011, Journal of biomolecular screening.

Application of a Continuous-Flow Bioassay to Investigate the Organic Solvent Tolerability of Cytochrome P450 BM3 Mutants

N. Vermeulen, J. Commandeur, J. Reinen, 2015, Journal of biomolecular screening.

Fish bioaccumulation and biomarkers in environmental risk assessment: a review.

Jonny Beyer, Nico P E Vermeulen, Ron van der Oost, 2003, Environmental toxicology and pharmacology.

Binding mode prediction of cytochrome p450 and thymidine kinase protein-ligand complexes by consideration of water and rescoring in automated docking.

Chris de Graaf, Gerd Folkers, Nico P E Vermeulen, 2005, Journal of medicinal chemistry.

Catalytic site prediction and virtual screening of cytochrome P450 2D6 substrates by consideration of water and rescoring in automated docking.

Chris Oostenbrink, Chris de Graaf, Nico P E Vermeulen, 2006, Journal of medicinal chemistry.

Identification of critical residues in novel drug metabolizing mutants of cytochrome P450 BM3 using random mutagenesis.

N. Vermeulen, C. Oostenbrink, B. V. van Vugt-Lussenburg, 2007, Journal of medicinal chemistry.

Structural rationalization of novel drug metabolizing mutants of cytochrome P450 BM3

N. Vermeulen, C. Oostenbrink, B. V. van Vugt-Lussenburg, 2008, Proteins.

Simulation of interindividual differences in inactivation of reactive para-benzoquinone imine metabolites of diclofenac by glutathione S-transferases in human liver cytosol.

N. Vermeulen, J. Commandeur, Michiel W. den Braver, 2016, Toxicology letters.

N. Vermeulen, Jolanda van Leeuwen, G. Vredenburg, 2011, Toxicology letters.

Dose-dependent stereoselectivity in the formation of mercapturic acids from cyclohexene oxide by the rat.

N. Vermeulen, P. van Bladeren, D. Breimer, 1981, Drug metabolism and disposition: the biological fate of chemicals.

Generalized cytochrome P450-mediated oxidation and oxygenation reactions in aromatic substrates with activated N-H, O-H, C-H, or S-H substituents.

L. Koymans, N. Vermeulen, J. T. te Koppele, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Enzyme-Catalyzed Activation of Anticancer Prodrugs

Nico P E Vermeulen, Martijn Rooseboom, N. Vermeulen, 2004, Pharmacological Reviews.

Determination and identification of estrogenic compounds generated with biosynthetic enzymes using hyphenated screening assays, high resolution mass spectrometry and off-line NMR.

Nico P E Vermeulen, Maarten Honing, Jeroen Kool, 2010, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Human glutathione S-transferases- and NAD(P)H:quinone oxidoreductase 1-catalyzed inactivation of reactive quinoneimines of amodiaquine and N-desethylamodiaquine: Possible implications for susceptibility to amodiaquine-induced liver toxicity.

N. Vermeulen, Shalenie P. den Braver-Sewradj, J. Commandeur, 2017, Toxicology letters.

Effect of human glutathione S-transferase hGSTP1-1 polymorphism on the detoxification of reactive metabolites of clozapine, diclofenac and acetaminophen.

N. Vermeulen, J. Commandeur, H. Venkataraman, 2014, Toxicology letters.

Human NAD(P)H:quinone oxidoreductase 1 (NQO1)-mediated inactivation of reactive quinoneimine metabolites of diclofenac and mefenamic acid.

N. Vermeulen, J. Commandeur, D. Hendriks, 2014, Chemical research in toxicology.

Effect of human glutathione S-transferases on glutathione-dependent inactivation of cytochrome P450-dependent reactive intermediates of diclofenac.

N. Vermeulen, J. Commandeur, S. Dragović, 2013, Chemical research in toxicology.

Role of human glutathione S-transferases in the inactivation of reactive metabolites of clozapine.

N. Vermeulen, J. Commandeur, S. Dragović, 2010, Chemical research in toxicology.

Molecular aspects of paracetamol-induced hepatotoxicity and its mechanism-based prevention.

N. Vermeulen, J. Bessems, N P Vermeulen, 1992, Drug metabolism reviews.

Biomonitoring of aquatic pollution with feral eel (Anguilla anguilla). II. Biomarkers: pollution-induced biochemical responses.

N. Vermeulen, A. Goksøyr, M. Celander, 1996 .

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole

N. Vermeulen, J. Commandeur, Stefan J. Dekker, 2018, British journal of pharmacology.

Online Biochemical Detection of Glutathione-S-Transferase P1-Specific Inhibitors in Complex Mixtures

N. Vermeulen, J. Meerman, J. Kool, 2007, Journal of biomolecular screening.

Toxicity of the cysteine-S-conjugates and mercapturic acids of four structurally related difluoroethylenes in isolated proximal tubular cells from rat kidney. Uptake of the conjugates and activation to toxic metabolites.

N. Vermeulen, G. Mulder, P. Boogaard, 1989, Biochemical pharmacology.

ASSESSMENT AND PREDICTION OF IN VIVO OXIDATIVE DRUG METABOLIZING ACTIVITY

M. Danhof, N. Vermeulen, D. Breimer, 1984 .

Intra-arterial administration of hexobarbital enantiomers to the rat: disposition and estimation of apparent extraction ratio

N. Vermeulen, D. Breimer, M. Graaff, 1986, Pharmaceutisch Weekblad.

Interactions of organophosphates with keratins in the cornified epithelium of human skin.

N. Vermeulen, D. Noort, A. Hulst, 2012, Chemico-Biological Interactions.

Effects of curcumin on cytochrome P450 and glutathione S-transferase activities in rat liver.

N. Vermeulen, J. Commandeur, S. Oetari, 1996, Biochemical pharmacology.

Mercapturic acids, protein adducts, and DNA adducts as biomarkers of electrophilic chemicals.

N. Vermeulen, N P Vermeulen, R T van Welie, 1992, Critical reviews in toxicology.

Liquid Chromatography/Tandem Mass Spectrometry Detection of Covalent Binding of Acetaminophen to Human Serum Albumin

N. Vermeulen, D. Noort, A. Hulst, 2007, Drug Metabolism and Disposition.

Simultaneous determination of tyrosine, phenylalanine and deoxyguanosine oxidation products by liquid chromatography-tandem mass spectrometry as non-invasive biomarkers for oxidative damage.

N. Vermeulen, J. Meerman, H. Zappey, 2004, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Mercapturic acids as biomarkers of exposure to electrophilic chemicals: applications to environmental and industrial chemicals.

N. Vermeulen, J. Commandeur, B. M. Rooij, 1998 .

Selective Biomarker for the Cytochrome P 450-Catalyzed Oxidation of 1 , 2-Dibromoethane in the Rat

N. Vermeulen, J. Commandeur, J. Ploemen, 1997 .

Allylmercapturic acid as urinary biomarker of human exposure to allyl chloride.

N. Vermeulen, P. Boogaard, J. Commandeur, 1997, Occupational and environmental medicine.

Urinary thiodiacetic acid. A selective biomarker for the cytochrome P450-catalyzed oxidation of 1,2-dibromoethane in the rat.

N. Vermeulen, P. van Bladeren, J. Commandeur, 1997, Drug metabolism and disposition: the biological fate of chemicals.

3-Chloro-2-hydroxypropylmercapturic acid and α-chlorohydrin as biomarkers of occupational exposure to epichlorohydrin.

N. Vermeulen, P. Boogaard, J. Commandeur, 1997, Environmental toxicology and pharmacology.

Disposition in rat of [2-3H]-trans-4-hydroxy-2,3-nonenal, a product of lipid peroxidation.

N. Vermeulen, J. Commandeur, L. D. De Zwart, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Identification and quantitative determination of 3-chloro-2-hydroxypropylmercapturic acid and alpha-chlorohydrin in urine of rats treated with epichlorohydrin.

H. Schuilenburg, N. Vermeulen, J. Commandeur, 1996, Journal of chromatography. B, Biomedical applications.

Polymorphism in the glutathione conjugation activity of human erythrocytes towards ethylene dibromide and 1,2-epoxy-3-(p-nitrophenoxy)-propane.

N. Vermeulen, P. van Bladeren, B. van Ommen, 1995, Biochimica et biophysica acta.

The metabolic formation of N-acetyl-S-2-hydroxyethyl-L-cysteine from tetradeutero-1,2-dibromoethane. relative importance of oxidation and glutathione conjugation in vivo.

N. Vermeulen, P. van Bladeren, D. Breimer, 1981, Biochemical pharmacology.

Identification and quantitative determination of four different mercapturic acids formed from 1,3-dibromopropane and its 1,1,3,3-tetradeutero analogue by the rat.

N. Vermeulen, W. Buijs, W. Onkenhout, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Analysis of mercapturic acids as a tool in biotransformation, biomonitoring and toxicological studies.

N. Vermeulen, 1989, Trends in pharmacological sciences.

Determination of two mercapturic acid metabolites of 1,3-dichloropropene in human urine with gas chromatography and sulphur-selective detection.

N. Vermeulen, R. T. van Welie, P. Van Duyn, 1989, Journal of chromatography.

Thioether excretion in urine of applicators exposed to 1,3-dichloropropene: a comparison with urinary mercapturic acid excretion.

N. Vermeulen, F. A. de Wolff, R. T. van Welie, 1991, British journal of industrial medicine.

Determination of tetrahydrophtalimide and 2-thiothiazolidine-4-carboxylic acid, urinary metabolites of the fungicide captan, in rats and humans

N. Vermeulen, R. T. H. Welie, P. Duyn, 1991, International archives of occupational and environmental health.

Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part II. Biological monitoring by measurement of urinary excretion of two mercapturic acid metabolites

N. Vermeulen, D. Brouwer, J. V. Hemmen, 1991, Archives of environmental contamination and toxicology.

Strategies to characterize the mechanisms of action and the active sites of glutathione S-transferases: a review.

N. Vermeulen, E. M. van der Aar, K. Tan, 1998, Drug metabolism reviews.

A homology model for rat mu class glutathione S-transferase 4-4.

N. Vermeulen, M. D. de Groot, G. M. Donné-op den Kelder, 1996, Chemical research in toxicology.

Enzyme kinetics and substrate selectivities of rat glutathione S-transferase isoenzymes towards a series of new 2-substituted 1-chloro-4-nitrobenzenes.

N. Vermeulen, P. van Bladeren, B. van Ommen, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Selenium-induced protection against cis-diamminedichloroplatinum(II) nephrotoxicity in mice and rats.

N. Vermeulen, J. Mcvie, G. Los, 1989, Cancer research.

Structure-activity relationships for the inhibition of recombinant human cytochromes P450 by curcumin analogues.

I. D. de Esch, N. Vermeulen, J. Commandeur, 2008, European journal of medicinal chemistry.

Inhibition of human recombinant cytochrome P450s by curcumin and curcumin decomposition products.

N. Vermeulen, B. V. van Vugt-Lussenburg, J. Commandeur, 2007, Toxicology.

Molecular modeling approaches to predicting drug metabolism and toxicity.

N. Vermeulen, A. T. Laak, M. Groot, 2002 .

A theoretical study on the metabolic activation of paracetamol by cytochrome P-450: indications for a uniform oxidation mechanism.

J. H. van Lenthe, L. Koymans, N. Vermeulen, 1988, Chemical research in toxicology.

Application of cytochrome P450 BM3 mutants as biocatalysts for the profiling of estrogen receptor binding metabolites of the mycotoxin zearalenone

N. Vermeulen, J. Commandeur, J. Reinen, 2011, Xenobiotica; the fate of foreign compounds in biological systems.

A novel microplate reader-based high-throughput assay for estrogen receptor binding

N. Vermeulen, J. Meerman, J. Kool, 2005 .

Application of lipid peroxidation and protein oxidation biomarkers for oxidative damage in mammalian cells. A comparison with two fluorescent probes.

N. Vermeulen, H. Gurer-Orhan, H. Orhan, 2006, Toxicology in vitro : an international journal published in association with BIBRA.

Cytochromes P450: their active-site structure and mechanism of oxidation.

L. Koymans, N. Vermeulen, G. M. Donné-op den Kelder, 1993, Drug metabolism reviews.

Identification of CYP1A2 Ligands by Structure-Based and Ligand-Based Virtual Screening

N. Vermeulen, C. Oostenbrink, L. Olsen, 2011 .

Bioactivation of selenocysteine Se-conjugates by a highly purified rat renal cysteine conjugate beta-lyase/glutamine transaminase K.

N. Vermeulen, I. Andreadou, J. Commandeur, 2000, The Journal of pharmacology and experimental therapeutics.

Variability in nifedipine pharmacokinetics and dynamics: a new oxidation polymorphism in man.

M. Danhof, N. Vermeulen, D. Breimer, 1984, Biochemical pharmacology.

Contribution of 4-hydroxy-2,3-trans-nonenal to the reduction of beta-adrenoceptor function in the heart by oxidative stress.

N. Vermeulen, A. Bast, H. Timmerman, 1989, Life sciences.

Application of drug metabolising mutants of Cytochrome P450 BM3 as biocatalysts for the generation of reactive metabolites

N. Vermeulen, J. Commandeur, B. V. Vugt-Lussenburg, 2012 .

Application of drug metabolising mutants of cytochrome P450 BM3 (CYP102A1) as biocatalysts for the generation of reactive metabolites.

N. Vermeulen, B. V. van Vugt-Lussenburg, J. Commandeur, 2008, Chemico-biological interactions.

Biomonitoring aquatic pollution with feral eel (Anguilla anguilla): I. Bioaccumulation: biota-sediment ratios of PCBs, OCPs, PCDDs and PCDFs.

N. Vermeulen, A. Opperhuizen, R. Oost, 1996 .

Characterization of Human Cytochrome P450s Involved in the Bioactivation of Clozapine

M. Ingelman-Sundberg, N. Vermeulen, J. Commandeur, 2013, Drug Metabolism and Disposition.

Development of a Novel Cytochrome P450 Bioaffinity Detection System Coupled Online to Gradient Reversed-Phase High-Performance Liquid Chromatography

N. Vermeulen, J. Meerman, R. Ramautar, 2005, Journal of biomolecular screening.

Application of a cocktail approach to screen cytochrome P450 BM3 libraries for metabolic activity and diversity

M. Honing, N. Vermeulen, G. Postma, 2016, Analytical and Bioanalytical Chemistry.

R OLE OF RESIDUE 87 IN THE ACTIVITY AND REGIOSELECTIVITY OF CLOZAPINE METABOLISM BY DRUG METABOLIZING BM 3 M 11 : APPLICATION FOR STRUCTURAL CHARACTERIZATION OF CLOZAPINE GSH CONJUGATES

N. Vermeulen, J. Commandeur, S. Dragović, 2012 .

Development and validation of a microsomal online cytochrome P450 bioreactor coupled to solid-phase extraction and reversed-phase liquid chromatography.

N. Vermeulen, J. Meerman, J. Kool, 2005, Journal of chromatography. A.

Comprehensive and Automated Linear Interaction Energy Based Binding-Affinity Prediction for Multifarious Cytochrome P450 Aromatase Inhibitors

J. Wichard, N. Vermeulen, A. T. Laak, 2017, J. Chem. Inf. Model..

The use of in vitro metabolic parameters and physiologically based pharmacokinetic (PBPK) modeling to explore the risk assessment of trichloroethylene.

N. Vermeulen, P. van Bladeren, J. Commandeur, 2002, Environmental toxicology and pharmacology.

PREPARATION OF WALL-COATED OPEN-TUBULAR CAPILLARY COLUMNS FOR GAS-CHROMATOGRAPHY

N. Vermeulen, B. Xu, B. Xu, 1988 .

A combined computational and experimental study on selective flucloxacillin hydroxylation by cytochrome P450 BM3 variants.

Rosa A. Luirink, N. Vermeulen, D. Geerke, 2018, Journal of inorganic biochemistry.

Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme

L. Dijkhuizen, N. Vermeulen, J. Commandeur, 2015, Applied Microbiology and Biotechnology.

Yeast as a humanized model organism for biotransformation-related toxicity.

N. Vermeulen, Jolanda van Leeuwen, J. Chris Vos, 2012, Current drug metabolism.

Bioaccumulation, biotransformation and DNA-binding of PAHs in feral eel (Anguilla anguilla), exposed to polluted sediments: A field survey

N. Vermeulen, F. J. Schooten, F. Ariese, 1995 .

Simultaneous determination of eight lipid peroxidation degradation products in urine of rats treated with carbon tetrachloride using gas chromatography with electron-capture detection.

J. Venhorst, N. Vermeulen, J. Commandeur, 1997, Journal of chromatography. B, Biomedical sciences and applications.

Bioaccumulation of organic micropollutants in different aquatic organisms. Sublethal toxic effects on fish

N. Vermeulen, A. Opperhuizen, R. Oost, 1991 .

Assessment of environmental quality and inland water pollution using biomarker responses in caged carp (Cyprinus carpio): Use of a bioactivation:detoxication ratio as a Biotransformation Index (BTI)

N. Vermeulen, H. Komen, R. Oost, 1998 .

Biochemical markers in feral roach (Rutilus rutilus) in relation to the bioaccumulation of organic trace pollutants

N. Vermeulen, F. J. Schooten, L. V. Gastel, 1994 .

Meet Our Associate Editor

N. Vermeulen, 2017 .

Efficient Screening of Cytochrome P450 BM3 Mutants for Their Metabolic Activity and Diversity toward a Wide Set of Drug-Like Molecules in Chemical Space

P. Grootenhuis, N. Vermeulen, C. Decker, 2011, Drug Metabolism and Disposition.

Active site substitution A82W improves the regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalized by spin relaxation nuclear magnetic resonance studies.

S. Wijmenga, M. Honing, N. Vermeulen, 2012, Biochemistry.

Generic method for the absolute quantification of glutathione S-conjugates: Application to the conjugates of acetaminophen, clozapine and diclofenac.

N. Vermeulen, J. Commandeur, Michiel W. den Braver, 2017, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Characterization of cytochrome P450 isoforms involved in sequential two-step bioactivation of diclofenac to reactive p-benzoquinone imines.

N. Vermeulen, Shalenie P. den Braver-Sewradj, J. Commandeur, 2016, Toxicology letters.

One-electron oxidation of diclofenac by human cytochrome P450s as a potential bioactivation mechanism for formation of 2'-(glutathion-S-yl)-deschloro-diclofenac.

N. Vermeulen, J. Commandeur, J. Boerma, 2014, Chemico-biological interactions.

Bioaccumulation, biotransformation and DNA binding of pahs in feral eel (Anguilla anguilla) exposed to polluted sediments: A field survey

N. Vermeulen, F. J. Schooten, R. Oost, 1994 .

Reconstitution of the interplay between cytochrome P450 and human glutathione S-transferases in clozapine metabolism in yeast.

N. Vermeulen, J. Commandeur, G. Vredenburg, 2013, Toxicology letters.

Computational Prediction of Binding Affinity for CYP1A2-Ligand Complexes Using Empirical Free Energy Calculations

Chris Oostenbrink, Lars Olsen, Poongavanam Vasanthanathan, 2010, Drug Metabolism and Disposition.

Inter-individual Variability in Activity of the Major Drug Metabolizing Enzymes in Liver Homogenates of 20 Individuals.

N. Vermeulen, M. van Dijk, Shalenie P. den Braver-Sewradj, 2018, Current drug metabolism.

Interrelationships between bioaccumulation of organic trace pollutants (PCBs, organochlorine pesticides and PAHs), and MFO-induction in fish.

N. Vermeulen, A. Opperhuizen, R. van der Oost, 1991, Comparative biochemistry and physiology. C, Comparative pharmacology and toxicology.

Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization

N. Vermeulen, J. Kool, J. Reinen, 2008, Analytical and bioanalytical chemistry.

Molecular mechanisms of toxic effects of fotemustine in rat hepatocytes and subcellular rat liver fractions.

N. Vermeulen, J. Commandeur, L. W. Wormhoudt, 1996, Carcinogenesis.

Urinary excretion of biomarkers of oxidative kidney damage induced by ferric nitrilotriacetate.

N. Vermeulen, J. Commandeur, L. D. De Zwart, 1998, Toxicological sciences : an official journal of the Society of Toxicology.

Reduction and Scavenging of Chemically Reactive Drug Metabolites by NAD(P)H:Quinone Oxidoreductase 1 and NRH:Quinone Oxidoreductase 2 and Variability in Hepatic Concentrations

N. Vermeulen, Shalenie P. den Braver-Sewradj, J. Commandeur, 2017, Chemical research in toxicology.

Glutathione S-Transferase P1 Protects Against Amodiaquine Quinoneimines-Induced Cytotoxicity but Does Not Prevent Activation of Endoplasmic Reticulum Stress in HepG2 Cells

N. Vermeulen, B. van de Water, Shalenie P. den Braver-Sewradj, 2018, Front. Pharmacol..

Mini-dialysis tubes as tools to prepare drug-protein adducts of P450-dependent reactive drug metabolites.

N. Vermeulen, J. Commandeur, Naura S Elias, 2015, Journal of pharmaceutical and biomedical analysis.

Application of CYP102A1M11H as a tool for the generation of protein adducts of reactive drug metabolites.

N. Vermeulen, J. Commandeur, J. Boerma, 2011, Chemical research in toxicology.

Selenoxidation by flavin-containing monooxygenases as a novel pathway for beta-elimination of selenocysteine Se-conjugates.

N. Vermeulen, A. Rettie, J. Commandeur, 2001, Chemical research in toxicology.

Monitoring of oxidative free radical damage in vivo: analytical aspects.

N. Vermeulen, A. Bast, J. Hageman, 1992, Chemico-biological interactions.

Excretion of multiple urinary biomarkers for radical induced damage in rats treated with three different nephrotoxic compounds.

N. Vermeulen, J. Commandeur, L. D. De Zwart, 1998, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

4-Hydroxy-2,3-trans-nonenal stimulates microsomal lipid peroxidation by reducing the glutathione-dependent protection.

N. Vermeulen, A. Bast, H. Timmerman, 1987, Archives of biochemistry and biophysics.

Principles of Pharmacology and Toxicology Also Govern Effects of Chemicals on the Endocrine System.

G. B. Gori, D. Dietrich, N. Vermeulen, 2015, Toxicological sciences : an official journal of the Society of Toxicology.

Combination of biotransformation by P450 BM3 mutants with on-line post-column bioaffinity and mass spectrometric profiling as a novel strategy to diversify and characterize p38α kinase inhibitors

M. Honing, N. Vermeulen, J. Kool, 2013 .

C OMBINATION OF BIOTRANSFORMATION BY P 450 BM 3 MUTANTS WITH ON-LINE POST-COLUMN BIOAFFINITY AND MASS SPECTROSCOPIC PROFILING AS A NOVEL STRATEGY TO DIVERSIFY AND CHARACTERIZE P 38 KINASE INHIBITORS

N. Vermeulen, J. Kool, W. Niessen, 2012 .

Bioactivation of dibrominated biphenyls by cytochrome P450 activity to metabolites with estrogenic activity and estrogen sulfotransferase inhibition capacity.

N. Vermeulen, T. Visser, J. Meerman, 2005, Chemical research in toxicology.

Identification and quantitative determination of glutathione-related urinary metabolites of fotemustine, a new anti-cancer agent.

N. Vermeulen, M. Lamoree, J. Commandeur, 1993, Xenobiotica; the fate of foreign compounds in biological systems.

Cytochrome P450 catalyzed metabolism of 1,2-dibromoethane in liver microsomes of differentially induced rats.

N. Vermeulen, P. van Bladeren, B. van Ommen, 1996, Chemico-biological interactions.

Prediction of ligand binding affinity and orientation of xenoestrogens to the estrogen receptor by molecular dynamics simulations and the linear interaction energy method.

Nico P E Vermeulen, Aldo Jongejan, N. Vermeulen, 2004, Journal of medicinal chemistry.

Fish biomarkers and environmental risk assessment: a review

N. Vermeulen, J. Beyer, R. Oost, 2003 .

Engineering a self-sufficient Mycobacterium tuberculosis CYP130 by gene fusion with the reductase-domain of CYP102A1 from Bacillus megaterium.

Nico P E Vermeulen, Rosa A. Luirink, Wilbert Bitter, 2018, Journal of inorganic biochemistry.

Biomonitoring aquatic pollution with feral eel (Anguilla anguilla); III. statistical analyses of relationships between contaminant exposure and biomarkers

N. Vermeulen, É. Vindimian, P. J. Brink, 1997 .

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11

M. Honing, N. Vermeulen, J. Commandeur, 2011, JBIC Journal of Biological Inorganic Chemistry.

Activation of the anticancer drugs cyclophosphamide and ifosfamide by cytochrome P450 BM3 mutants.

N. Vermeulen, Shalenie P. den Braver-Sewradj, B. V. van Vugt-Lussenburg, 2015, Toxicology letters.

Environmental and biological monitoring of non-occupational exposure to 1,3-dichloropropene

N. Vermeulen, R. T. H. Welie, P. Duyn, 1991, International archives of occupational and environmental health.

Biotransformation of allyl chloride in the rat. Influence of inducers on the urinary metabolic profile.

N. Vermeulen, P. Boogaard, J. Commandeur, 1996, Drug metabolism and disposition: the biological fate of chemicals.

Cytochrome p450 in silico: an integrative modeling approach.

Chris de Graaf, Nico P E Vermeulen, K Anton Feenstra, 2005, Journal of medicinal chemistry.

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats.

N. Vermeulen, D. Breimer, M. van der Graaff, 1983, The Journal of pharmacology and experimental therapeutics.

Pharmacokinetics of simultaneously administered hexobarbital and heptabarbital in rats: an alternative approach to metabolic correlation studies.

N. Vermeulen, D. Breimer, P. Langendijk, 1983, The Journal of pharmacology and experimental therapeutics.

Disposition of hexobarbital enantiomers in the rat.

N. Vermeulen, D. Breimer, M. van der Graaff, 1983, Drug metabolism and disposition: the biological fate of chemicals.

Disposition of hexobarbital in the rat. Estimation of "first-pass" elimination and influence of ether anesthesia.

M. Danhof, N. Vermeulen, D. Breimer, 1983, The Journal of pharmacology and experimental therapeutics.

GLUCURONIDE CONJUGATION AS AN ALTERNATIVE BIOTRANSFORMATION PATHWAY OF HEXOBARBITAL AND METHOHEXITAL IN RATS WITH EXPERIMENTAL HEPATITIS AND CHOLESTASIS

N. Vermeulen, D. Breimer, H. Flechtner, 1982 .

The effect of hydrogen peroxide on beta-adrenoceptor function in the heart.

N. Vermeulen, A. Bast, H. Timmerman, 1988, Free radical research communications.

A Single Active Site Mutation Inverts Stereoselectivity of 16‐Hydroxylation of Testosterone Catalyzed by Engineered Cytochrome P450 BM3

N. Vermeulen, D. Geerke, J. Commandeur, 2012, Chembiochem : a European journal of chemical biology.

Chapter 7 On-line diversity screening of cytochrome P 450 BM 3 mutant libraries

N. Vermeulen, J. Reinen, Suilan Ferman, 2010 .

Inhalation exposure to 1,3-dichloropropene in the Dutch flower-bulb culture. Part I. Environmental monitoring

N. Vermeulen, D. Brouwer, J. V. Hemmen, 1991 .

Cytochrome P450 bio-affinity detection coupled to gradient HPLC: on-line screening of affinities to cytochrome P4501A2 and 2D6.

Nico P E Vermeulen, Jeroen Kool, N. Vermeulen, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Escherichia coli MTC, a NADPH cytochrome P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450: comparison of three types of expression systems.

C. W. Fisher, N. Vermeulen, R. Estabrook, 1999, Mutation research.

Application of engineered cytochrome P450 mutants as biocatalysts for the synthesis of benzylic and aromatic metabolites of fenamic acid NSAIDs.

Nico P E Vermeulen, Luigi Capoferri, Harini Venkataraman, 2014, Bioorganic & medicinal chemistry.

Insights into regioselective metabolism of mefenamic acid by cytochrome P450 BM3 mutants through crystallography, docking, molecular dynamics, and free energy calculations

Lars Olsen, Nico P E Vermeulen, Flemming Steen Jørgensen, 2016, Proteins.

Bioactivation of chemopreventive selenocysteine Se-conjugates and related amino acids by amino acid oxidases novel route of metabolism of selenoamino acids.

N. Vermeulen, J. Commandeur, M. Rooseboom, 2001, Chemical research in toxicology.

Synthesis of novel Se-substituted selenocysteine derivatives as potential kidney selective prodrugs of biologically active selenol compounds: evaluation of kinetics of beta-elimination reactions in rat renal cytosol.

N. Vermeulen, I. Andreadou, J. Commandeur, 1996, Journal of medicinal chemistry.

Tissue distribution of cytosolic beta-elimination reactions of selenocysteine Se-conjugates in rat and human.

N. Vermeulen, J. Commandeur, M. Rooseboom, 2002, Chemico-biological interactions.

Evaluation of the kinetics of beta-elimination reactions of selenocysteine Se-conjugates in human renal cytosol: possible implications for the use as kidney selective prodrugs.

N. Vermeulen, I. Andreadou, J. Commandeur, 2000, The Journal of pharmacology and experimental therapeutics.

N-acetyl-S-(2-hydroxyethyl)-L-cysteine as a potential tool in biological monitoring studies?

N. Vermeulen, J. Jong, R. T. H. Welie, 1989, Archives of Toxicology.

Chemical and glutathione conjugation-related degradation of fotemustine: formation and characterization of a glutathione conjugate of diethyl (1-isocyanatoethyl)phosphonate, a reactive metabolite of fotemustine.

N. Vermeulen, J. Commandeur, F. D. de Kanter, 1994, Chemical research in toxicology.

Rat liver microsomal cytochrome P450-dependent oxidation of 3,5-disubstituted analogues of paracetamol.

N. Vermeulen, J. Bessems, L. V. van Stee, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Mutagenicity and cytotoxicity of two regioisomeric mercapturic acids and cysteine S-conjugates of trichloroethylene

N. Vermeulen, G. Mulder, P. Boogaard, 2005, Archives of Toxicology.

Urinary metabolite profile of phenyl and o-cresyl glycidyl ether in rats: identification of a novel pathway leading to N-acetylserine O-conjugates.

N. Vermeulen, J. Commandeur, B. D. de Rooij, 1998, Chemical research in toxicology.

Identification of N-acetyl(2,2-dichlorovinyl)- and N-acetyl(1,2-dichlorovinyl)-L-cysteine as two regioisomeric mercapturic acids of trichloroethylene in the rat.

N. Vermeulen, J. Commandeur, J. Commandeur, 1990, Chemical research in toxicology.

Metabolism and kinetics of trichloroethylene in relation to toxicity and carcinogenicity. Relevance of the mercapturic acid pathway.

N. Vermeulen, P. van Bladeren, B. van Ommen, 1995, Chemical research in toxicology.

Bioactivation of the cysteine-S-conjugate and mercapturic acid of tetrafluoroethylene to acylating reactive intermediates in the rat: dependence of activation and deactivation activities on acetyl coenzyme A availability.

N. Vermeulen, F. D. de Kanter, J. Commandeur, 1989, Molecular pharmacology.

Bioactivation of S-(2,2-dihalo-1,1-difluoroethyl)-L-cysteines and S-(trihalovinyl)-L-cysteines by cysteine S-conjugate beta-lyase: indications for formation of both thionoacylating species and thiiranes as reactive intermediates.

L. Koymans, N. Vermeulen, L. J. King, 1996, Chemical research in toxicology.

Escherichia coli MTC, a human NADPH P450 reductase competent mutagenicity tester strain for the expression of human cytochrome P450 isoforms 1A1, 1A2, 2A6, 3A4, or 3A5: catalytic activities and mutagenicity studies.

C. W. Fisher, N. Vermeulen, R. Estabrook, 1999, Mutation research.

An on-line post-column detection system for the detection of reactive-oxygen-species-producing compounds and antioxidants in mixtures

N. Vermeulen, J. Kool, H. Irth, 2007, Analytical and bioanalytical chemistry.

Enzymes and transport systems involved in the formation and disposition of glutathione S-conjugates. Role in bioactivation and detoxication mechanisms of xenobiotics.

N. Vermeulen, J. Commandeur, G. J. Stijntjes, 1995, Pharmacological reviews.

Studies on the inhibition of human cytochromes P450 by selenocysteine Se -conjugates

J. Venhorst, N. Vermeulen, J. Commandeur, 2003, Xenobiotica; the fate of foreign compounds in biological systems.

Stereoselective Bioactivation and Bioinactivation — Toxicological Aspects

N. Vermeulen, 2003 .

Selection of effective antisense oligodeoxynucleotides with a green fluorescent protein-based assay. Discovery of selective and potent inhibitors of glutathione S-transferase Mu expression.

M. Manoharan, N. Vermeulen, T. V. van Berkel, 2002, European journal of biochemistry.

Beta-lyase-dependent attenuation of cisplatin-mediated toxicity by selenocysteine Se-conjugates in renal tubular cell lines.

G. Schaaf, N. Vermeulen, J. Fink-Gremmels, 2002, The Journal of pharmacology and experimental therapeutics.

Enzymatic pathways of beta elimination of chemopreventive selenocysteine Se conjugates.

N. Vermeulen, J. Commandeur, M. Rooseboom, 2002, Methods in enzymology.

Chemistry and biological activity of novel selenium-containing compounds.

N. Vermeulen, J. Commandeur, M. Rooseboom, 2001, Advances in experimental medicine and biology.

Trichloroethylene Risk Assessment: Relevance of Interindividual Differences

N. Vermeulen, P. J. Bladeren, N. Vermeulen, 2001 .

Toxicity of fotemustine in rat hepatocytes and mechanism-based protection against it.

N. Vermeulen, J. Commandeur, L. W. Wormhoudt, 1998, Chemico-biological interactions.

Disposition of 1,2-[14C]Dibromoethane in male Wistar rats.

N. Vermeulen, P. van Bladeren, J. Commandeur, 1998, Drug metabolism and disposition: the biological fate of chemicals.

Comparative cytotoxicity of 14 novel selenocysteine se-conjugates in rat renal proximal tubular cells.

N. Vermeulen, B. van de Water, I. Andreadou, 1996, Toxicology and applied pharmacology.

Disposition of allylic oxidation pathway metabolites of racemic hexobarbital in the rat

N. Vermeulen, D. Breimer, M. Graaff, 1986, European Journal of Drug Metabolism and Pharmacokinetics.

Disposition of hexobarbitone in healthy man: kinetics of parent drug and metabolites following oral administration.

N. Vermeulen, D. Breimer, C. Rietveld, 1983, British journal of clinical pharmacology.

The epoxide-diol pathway in the metabolism of hexobarbital in rat and man.

N. Vermeulen, D. Breimer, A. van der Gen, 1979, Xenobiotica; the fate of foreign compounds in biological systems.

Identification and quantitative determination of mercapturic acids formed from Z- and E-1,3-dichloropropene by the rat, using gas chromatography with three different detection techniques

N. Vermeulen, P. Boogaard, W. Buijs, 1986, Archives of Toxicology.

Biotransformation and quantitative determination of sulfur-containing metabolites of 1,4-dibromobutane in the rat.

N. Vermeulen, W. Buijs, W. V. van Loon, 1986, Drug metabolism and disposition: the biological fate of chemicals.

Electron impact mass spectrometric analysis of mercapturic acid methyl esters: fragmentation of mercapturic acid methyl esters according to retro-Michael reactions

N. Vermeulen, H. J. Jong, W. Onkenhout, 1983 .

Correlation between the in vivo metabolism of hexobarbital and antipyrine in rats with a portacaval shunt.

N. Vermeulen, D. Breimer, M. van der Graaff, 1984, Pharmacology.

Topological role of cytochrome P450 2D6 active site residues.

Chris de Graaf, Nico P E Vermeulen, N. Vermeulen, 2006, Archives of biochemistry and biophysics.

Cytotoxicity and cytoprotective activities of natural compounds. The case of curcumin.

N. Vermeulen, J. Commandeur, 1996, Xenobiotica; the fate of foreign compounds in biological systems.

Cytotoxic and cytoprotective activities of curcumin. Effects on paracetamol-induced cytotoxicity, lipid peroxidation and glutathione depletion in rat hepatocytes.

N. Vermeulen, I. A. Donatus, Sardjoko, 1990, Biochemical pharmacology.

Induction of glutathione-S-transferase mRNA levels by chemopreventive selenocysteine Se-conjugates.

N. Vermeulen, T. V. van Berkel, J. Commandeur, 2002, Biochemical pharmacology.

Nephrotoxicity of mercapturic acids of three structurally related 2,2-difluoroethylenes in the rat. Indications for different bioactivation mechanisms.

N. Vermeulen, F. D. de Kanter, J. Commandeur, 1988, Biochemical pharmacology.

Purification of glutamine transaminase K/cysteine conjugate beta-lyase from rat renal cytosol based on hydrophobic interaction HPLC and gel permeation FPLC.

N. Vermeulen, J. Commandeur, G. J. Stijntjes, 1993, Protein expression and purification.

High-performance liquid chromatography-fluorescence assay of pyruvic acid to determine cysteine conjugate beta-lyase activity: application to S-1,2-dichlorovinyl-L-cysteine and S-2-benzothiazolyl-L-cysteine.

N. Vermeulen, J. T. te Koppele, G. J. Stijntjes, 1992, Analytical biochemistry.

Identification and quantitative determination of a carboxylic and a mercapturic acid metabolite of etridiazole in urine of rat and man. Potential tools for biological monitoring

N. Vermeulen, R. T. H. Welie, P. Duyn, 1991, Archives of Toxicology.

Metabolism of L-cysteine S-conjugates and N-(trideuteroacetyl)-L-cysteine S-conjugates of four fluoroethylenes in the rat. Role of balance of deacetylation and acetylation in relation to the nephrotoxicity of mercapturic acids.

N. Vermeulen, J. Commandeur, G. J. Stijntjes, 1991, Biochemical pharmacology.

alpha-Bromoisovalerylurea as model substrate for studies on pharmacokinetics of glutathione conjugation in the rat. II. Pharmacokinetics and stereoselectivity of metabolism and excretion in vivo and in the perfused liver.

N. Vermeulen, G. Mulder, D. Meijer, 1986, The Journal of pharmacology and experimental therapeutics.

Nephrotoxicity and hepatotoxicity of 1,1-dichloro-2,2-difluoroethylene in the rat. Indications for differential mechanisms of bioactivation.

N. Vermeulen, J. Commandeur, R. Oostendorp, 1987, Biochemical pharmacology.

Cytochrome P450 2B1-mediated one-electron reduction of adriamycin: a study with rat liver microsomes and purified enzymes.

N. Vermeulen, J. Piqué, J. T. te Koppele, 1993, Molecular pharmacology.

Selection of antisense oligodeoxynucleotides against glutathione S-transferase Mu.

Nico P E Vermeulen, F. V. van Batenburg, M. Manoharan, 2002, RNA.

Role of metabolism in chemical toxicity.

Nico P. E. Vermeulen, C. Ioannides, N. Vermeulen, 1996 .

4-Substituted 1-chloro-2-nitrobenzenes: structure-activity relationships and extension of the substrate model of rat glutathione S-transferase 4-4.

N. Vermeulen, M. D. de Groot, E. M. van der Aar, 1997, Chemical research in toxicology.

Genetic deficiency of human class mu glutathione S-transferase isoenzymes in relation to the urinary excretion of the mercapturic acids of Z- and E-1,3-dichloropropene

C. Evelo, N. Vermeulen, W. Peters, 2005, Archives of Toxicology.

Automated detection of covalent adducts to human serum albumin by immunoaffinity chromatography, on-line solution phase digestion and liquid chromatography-mass spectrometry.

N. Vermeulen, H. Irth, W. Niessen, 2007, Journal of chromatography. B, Analytical technologies in the biomedical and life sciences.

Cytotoxicity of paracetamol and 3,5-dihalogenated analogues: Role of cytochrome P-450 and formation of GSH conjugates and protein adducts.

N. Vermeulen, J. Bessems, L. V. van Stee, 1997, Toxicology in vitro : an international journal published in association with BIBRA.

Novel piperidine derivatives: inhibitory properties towards cytochrome P450 isoforms, and cytoprotective and cytotoxic characteristics.

N. Vermeulen, J. Commandeur, P. Kourounakis, 1996, Environmental toxicology and pharmacology.

3,5-Disubstituted analogues of paracetamol. Synthesis, analgesic activity and cytotoxicity.

N. Vermeulen, J. Bessems, W. P. van Bennekom, 1995, Chemico-biological interactions.

Mechanism of protection of lobenzarit against paracetamol-induced toxicity in rat hepatocytes

N. Vermeulen, J. Commandeur, D. Remírez, 1995 .

Mechanism of protection of ebselen against paracetamol-induced toxicity in rat hepatocytes.

N. Vermeulen, J. Bessems, J. Commandeur, 1994, Biochemical pharmacology.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives. Comparison of their microsomal cytochrome P-450 dependent oxidation and toxicity in freshly isolated hepatocytes.

N. Vermeulen, A. Debets, J. de Vries, 1986, Biochemical pharmacology.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl-substituted derivatives. Antioxidant activity and relationship between lipid peroxidation and cytotoxicity.

N. Vermeulen, G. Bijloo, R. van de Straat, 1988, Biochemical pharmacology.

The mechanism of prevention of paracetamol-induced hepatotoxicity by 3,5-dialkyl substitution. The roles of glutathione depletion and oxidative stress.

N. Vermeulen, A. Debets, J. de Vries, 1987, Biochemical pharmacology.

Cytochrome P-450-mediated oxidation of substrates by electron-transfer; role of oxygen radicals and of 1- and 2-electron oxidation of paracetamol.

N. Vermeulen, J. de Vries, R. van de Straat, 1988, Chemico-biological interactions.

USING SITE-DIRECTED AND RANDOM MUTAGENESIS FOR THE GENERATION OF HIGHLY ACTIVE DRUG METABOLISING MUTANTS OF CYTOCHROME P450 BM3 part II

N. Vermeulen, L. C. Babel, B. V. Vugt-Lussenburg, 2012 .

High‐performance liquid chromatography‐based assay for glutathione transferase theta 2 activity: Application to characterize interindividual variability in human liver fractions

N. Vermeulen, J. Commandeur, Yongjie Zhang, 2018, Journal of pharmaceutical and biomedical analysis.

Different Reactive Metabolites of Nevirapine Require Distinct Glutathione S-Transferase Isoforms for Bioinactivation.

N. Vermeulen, J. Commandeur, Yongjie Zhang, 2016, Chemical Research in Toxicology.

Cytochrome P450-mediated bioactivation of mefenamic acid to quinoneimine intermediates and inactivation by human glutathione S-transferases.

N. Vermeulen, J. Commandeur, Michiel W. den Braver, 2014, Chemical research in toxicology.

Evidence-based selection of training compounds for use in the mechanism-based integrated prediction of drug-induced liver injury in man

Nico P E Vermeulen, Jan Snoeys, Magnus Ingelman-Sundberg, 2016, Archives of Toxicology.

Role of the conserved threonine 309 in mechanism of oxidation by cytochrome P450 2D6.

Chris de Graaf, Nico P E Vermeulen, Magnus Ingelman-Sundberg, 2005, Biochemical and biophysical research communications.

THE USE OF SULFENYL HALIDES IN THE SYNTHESIS OF MERCAPTURIC ACIDS AND THEIR ESTERS

N. Vermeulen, W. Buijs, W. Onkenhout, 2010 .

Capillary gas chromatographic analysis of mercapturic acids : Decomposition of mercapturic acids according to a “retro-Michael” reaction

N. Vermeulen, H. J. Jong, W. Onkenhout, 1982 .

Mass spectrometric characterization of protein adducts of multiple P450-dependent reactive intermediates of diclofenac to human glutathione-S-transferase P1-1.

N. Vermeulen, J. Commandeur, S. Dragović, 2012, Chemical research in toxicology.

Free-release static coating of glass capillary columns: Coating with medium polar and polar stationary phases

N. Vermeulen, Xu Bingjiu, 1984 .

Free release static coating of glass capillary columns; Static coating at elevated pressure — Theoretical considerations and practice

N. Vermeulen, B. Xu, B. Xu, 1984 .

Free release static coating of glass capillary columns; rapid coating at lower temperatures and elevated pressures

N. Vermeulen, B. Xu, B. Xu, 1985 .

Fused silica capillary deactivation with D4 in the presence of oxygen

N. Vermeulen, B. Xu, 1986 .

Examination of the structure-toxicity relationships of L-cysteine-S-conjugates of halogenated alkenes and their corresponding mercapturic acids in rat renal tissue slices.

A. J. Gandolfi, N. Vermeulen, J. Commandeur, 1993, Toxicology.

The effect of acetaminophen on ubiquitin homeostasis in Saccharomyces cerevisiae

N. Vermeulen, Tibor van Welsem, F. van Leeuwen, 2017, PloS one.

The role of lipid peroxidation in the nephrotoxicity of cisplatin.

N. Vermeulen, G. S. Baldew, G. Baldew, 1992, Biochemical pharmacology.

The influence of ebselen on the toxicity of cisplatin in LLC-PK1 cells.

N. Vermeulen, G. S. Baldew, A. P. Boymans, 1992, Biochemical pharmacology.

The mechanism of interaction between cisplatin and selenite.

N. Vermeulen, F. D. de Kanter, B. V. van Baar, 1991, Biochemical pharmacology.

Selective Reduction of cw-Diamminedichloroplatinum(II) Nephrotoxicity by Ebselen1

N. Vermeulen, J. Mcvie, Glenn S. Balden, 1990 .

Oxygen and xenobiotic reductase activities of cytochrome P450.

N. Vermeulen, N P Vermeulen, H. Scheerens, 1995, Critical reviews in toxicology.

USING SITE-DIRECTED MUTAGENESIS FOR DETERMINATION OF SUBSTRATE INTERACTION RESIDUES IN CYTOCHROME P450 2D6 part I

N. Vermeulen, P. Keizers, C. Graaf, 2012 .

Selective induction of cytochrome P450 3A1 by dexamethasone in cultured rat hepatocytes: analysis with a novel reverse transcriptase-polymerase chain reaction assay section sign.

P. Hoen, N. Vermeulen, T. V. van Berkel, 2000, Biochemical pharmacology.

Cytotoxicity of a series of mono- and di-substituted thiourea in freshly isolated rat hepatocytes: a preliminary structure-toxicity relationship study.

N. Vermeulen, J. Commandeur, W. Menge, 1998, Toxicology.

Role of hepatic microsomal and purified cytochrome P-450 in one-electron reduction of two quinone imines and concomitant reduction of molecular oxygen.

N. Vermeulen, J. de Vries, R. van de Straat, 1987, Biochemical pharmacology.

Reductase and oxidase activity of rat liver cytochrome P450 with 2,3,5,6-tetramethylbenzoquinone as substrate.

N. Vermeulen, J. T. te Koppele, E. Neve, 1992, Chemico-biological interactions.

One-electron reduction of mitomycin c by rat liver: role of cytochrome P-450 and NADPH-cytochrome P-450 reductase.

N. Vermeulen, R. van de Straat, R. Vromans, 1990, Xenobiotica; the fate of foreign compounds in biological systems.

A Flow-Through Fluorescence Polarization Detection System for Measuring GPCR-Mediated Modulation of cAMP Production

Rob Leurs, Nico P E Vermeulen, Michel Gillard, 2007, Journal of biomolecular screening.

Occurrence of a cytochrome P-450-containing mixed-function oxidase system in the pond snail, Lymnaea stagnalis.

N. Vermeulen, M. Wilbrink, Y. de Vries, 1991, Xenobiotica; the fate of foreign compounds in biological systems.

A THEORETICAL-STUDY ON THE OXIDATIVE-METABOLISM OF 4-CHLOROACETANILIDE BY CYTOCHROME-P450 - ALTERNATIVE MECHANISMS FOR MIGRATION OF 4-SUBSTITUENTS DURING ENZYMATIC OXIDATION

L. Koymans, N. Vermeulen, W. Menge, 2010 .

Active site mapping of various cytochromes P450 isozymes

L. Koymans, N. Vermeulen, Kelder G.M. Donné-Op den, 1990 .

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

N. Vermeulen, F. Russel, J. B. Koenderink, 2020, Archives of Toxicology.

Risk assessment of paracetamol-induced liver toxicity based on human in vitro data.

J. Kleinjans, N. Vermeulen, J. Proost, 2014 .

Electron impact and chemical ionization mass spectrometry of cis- and trans-S-(2-hydroxycyclohexyl)-N-acetyl-(1)-cysteine methyl esters.

N. Vermeulen, P. van Bladeren, J. Cauvet, 1980, Biomedical mass spectrometry.

Effects of 2,2′-dichlorobiphenyl on egg laying in the pond snail Lymnaea stagnalis

N. Vermeulen, E. Roubos, A. Maat, 1992 .

In vitro bioactivation of 3-(N-phenylamino)propane-1,2-diol by human and rat liver microsomes and recombinant P450 enzymes. Implications for toxic oil syndrome.

N. Vermeulen, A. Messeguer, J. Commandeur, 2007, Chemical research in toxicology.

Molecular and biochemical mechanisms of chemically induced nephrotoxicity: a review.

N. Vermeulen, J. Commandeur, 1990, Chemical research in toxicology.

Computer prediction and experimental validation of cytochrome P4502D6-dependent oxidation of GBR 12909.

N. Vermeulen, M. D. de Groot, M J de Groot, 1995, Drug metabolism and disposition: the biological fate of chemicals.

Glutathione-5-transferase activity in the digestive gland of the pond snail, Lymnaea stagnalis

N. Vermeulen, M. Wilbrink, N. C. V. D. Merbel, 1991 .

Cytochrome P450 in Silico: An Integrative Modeling Approach

Chris de Graaf, K. Anton Feenstra, Nico P. E. Vermeulen, 2005 .

Development of Three Parallel Cytochrome P450 Enzyme Affinity Detection Systems Coupled On-line to Gradient High-Performance Liquid Chromatography

N. Vermeulen, J. Kool, H. Irth, 2007, Drug Metabolism and Disposition.

Oxidative N-Dealkylation of p-Cyclopropyl-N,N-dimethylaniline. A Substituent Effect on a Radical-Clock Reaction Rationalized by Ab Initio Calculations on Radical Cation Intermediates.

N. Vermeulen, M. D. de Groot, R. Hanzlik, 1997, The Journal of organic chemistry.

Paracetamol, 3-monoalkyl- and 3,5-dialkyl derivatives: comparison of their hepatotoxicity in mice.

N. Vermeulen, J. de Vries, R. van de Straat, 1987, Toxicology and applied pharmacology.

Cytochromes P450 and drug resistance

N. Vermeulen, J. Doehmer, A. Goeptar, 2004, Cytotechnology.

Bioassays for the detection of chemicals that can form bioactivation‐dependent reactive free radicals

N. Vermeulen, A. V. van Wezel, J. Commandeur, 1999 .

Evaluation of alkoxyresorufins as fluorescent substrates for high-throughput screening of cytochrome P450BM3 and site-directed mutants

N. Vermeulen, L. C. Babel, J. Commandeur, 2005 .

Pharmacokinetics of orally administered hexobarbital in plasma and saliva of healthy subjects.

N. Vermeulen, D. Breimer, M. van der Graaff, 1986, Biopharmaceutics & drug disposition.

The role of protein plasticity in computational rationalization studies on regioselectivity in testosterone hydroxylation by cytochrome P450 BM3 mutants.

N. Vermeulen, D. Geerke, F. Bickelhaupt, 2012, Current drug metabolism.

Comprehensive medicinal chemistry

Aalt Bast, Henk Timmerman, Nico P. E. Vermeulen, 1991 .

Effect of thiols on lipid peroxidation in rat liver microsomes.

N. Vermeulen, A. Bast, H. Timmerman, 1989, Chemico-biological interactions.

Activation of the microsomal glutathione-S-transferase and reduction of the glutathione dependent protection against lipid peroxidation by acrolein.

N. Vermeulen, H. Timmerman, G. Haenen, 1987, Biochemical pharmacology.

One-electron reductive bioactivation of 2,3,5,6-tetramethylbenzoquinone by cytochrome P450.

N. Vermeulen, J. T. te Koppele, A. Goeptar, 1992, Biochemical pharmacology.

Reduction of antitumour mitosenes in non-aqueous and aqueous environment. An electron spin resonance and cyclic voltammetry study.

D. Reinhoudt, W. Verboom, N. Vermeulen, 1995, Free radical research.

Surface-enhanced resonance Raman scattering of cytochrome P450-2D6 on coated silver hydrosols.

N. Vermeulen, P. Keizers, A. Bonifacio, 2007, Langmuir : the ACS journal of surfaces and colloids.

Comprehensive medicinal chemistry

N. Vermeulen, A. Bast, H. Timmerman, 1991 .

Midazolam is a phenobarbital-like cytochrome p450 inducer in rats.

P. Hoen, N. Vermeulen, T. V. van Berkel, 2001, The Journal of pharmacology and experimental therapeutics.

Hydrogen atom abstraction of 3,5-disubstituted analogues of paracetamol by horseradish peroxidase and cytochrome P450.

N. Vermeulen, M. D. de Groot, J. Bessems, 1998, Xenobiotica; the fate of foreign compounds in biological systems.

Selenium-induced Protection against m-Dianirninedichloroplatinum(II) Nephrotoxicity in Mice and Rats1

N. Vermeulen, J. D. Goeij, G. Los, 2006 .

Mechanism of the reaction of ebselen with endogenous thiols: dihydrolipoate is a better cofactor than glutathione in the peroxidase activity of ebselen.

N. Vermeulen, A. Bast, G. Haenen, 1990, Molecular pharmacology.

Comparative cytotoxicity of N-substituted N'-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices.

N. Vermeulen, J. Commandeur, R. Onderwater, 2004, Toxicology.

Acetaminophen reduces the protein levels of high affinity amino acid permeases and causes tryptophan depletion

N. Vermeulen, J. Kooter, J. Vos, 2018, Amino Acids.

Mistaken identity: Paracetamol induces amino acid starvation through mimicry of tyrosine and changes ubiquitin homeostasis

N. Vermeulen, J. Kooter, J. Vos, 2022 .

Relationship between paracetamol binding to and its oxidation by two cytochromes P-450 isozymes--a proton nuclear magnetic resonance and spectrophotometric study.

N. Vermeulen, J. D. de Vries, R. van de Straat, 1987, Xenobiotica; the fate of foreign compounds in biological systems.

Elimination of drug metabolites in liver disease

N. Vermeulen, D. Breimer, W. Zilly, 1980 .

Activation of the microsomal glutathione S-transferase by metabolites of alpha-methyldopa.

N. Vermeulen, A. Bast, G. Haenen, 1991, Archives of biochemistry and biophysics.

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

N. Vermeulen, T. Grossmann, W. Bitter, 2018, Applied Microbiology and Biotechnology.

Pharmacokinetics of Lignocaine and Bupivacaine in Surgical Patients Following Epidural Administration

N. Vermeulen, D. Breimer, A. Burm, 1987, Clinical pharmacokinetics.

Active site substitution A82W improves regioselectivity of steroid hydroxylation by cytochrome P450 BM3 mutants as rationalised by spin relaxation NMR studies

S. Wijmenga, M. Honing, N. Vermeulen, 2011 .

Activation of microsomal glutathione S-transferase and inhibition of cytochrome P450 1A1 activity as a model system for detecting protein alkylation by thiourea-containing compounds in rat liver microsomes.

N. Vermeulen, J. Commandeur, W. Menge, 1999, Chemical research in toxicology.

Comparative study on the bioactivation mechanisms and cytotoxicity of Te-phenyl-L-tellurocysteine, Se-phenyl-L-selenocysteine, and S-phenyl-L-cysteine.

N. Vermeulen, J. Commandeur, M. Rooseboom, 2002, Chemical research in toxicology.

Conventional and novel approaches in generating and characterization of reactive intermediates from drugs/drug candidates.

N. Vermeulen, H. Orhan, 2011, Current drug metabolism.

Metabolite predictions for para-substituted anisoles based on ab initio complete active space self-consistent field calculations.

J. H. van Lenthe, N. Vermeulen, M. D. de Groot, 1995, Chemical research in toxicology.

LOSS OF HYDROGEN-CYANIDE FROM MONOCYANOPYRIDINES UPON ELECTRON-IMPACT - DEWAR PYRIDINE STRUCTURES AND RING OPENING-RING CLOSURE REACTIONS REVEALED BY C-13-LABELING AND N-15-LABELING

R. P. Morgan, J. Beynon, N. Vermeulen, 1979 .

Abstract of papers

E. Kroese, L. Bree, F. Zitman, 1987, Pharmaceutisch Weekblad.

Legacy data sharing to improve drug safety assessment: the eTOX project

Anne Hersey, Søren Brunak, Anthony J. Brookes, 2017, Nature Reviews Drug Discovery.

Selective reduction of cis-diamminedichloroplatinum(II) nephrotoxicity by ebselen.

N. Vermeulen, J. Mcvie, M. A. van der Valk, 1990, Cancer research.

Interactions between cytochromes P450, glutathione S-transferases and Ghanaian medicinal plants.

N. Vermeulen, J. Commandeur, R. Appiah-Opong, 2008, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

Simultaneous determination of glutathione, glutathione disulphide, paracetamol and its sulphur containing metabolites using HPLC and electrochemical detection with on-line generated bromine.

R. W. Frei, N. Vermeulen, A. Debets, 1988, Journal of pharmaceutical and biomedical analysis.

Development and validation of a fluorescence HPLC-based screening assay for inhibition of human estrogen sulfotransferase.

H. Glatt, N. Vermeulen, J. Reinen, 2006, Analytical biochemistry.

Pharmacokinetics of lidocaine and bupivacaine and stable isotope labelled analogues: A study in healthy volunteers

N. Vermeulen, D. Breimer, A. Burm, 1988, Biopharmaceutics & drug disposition.

Evaluation of urinary biomarkers for radical-induced liver damage in rats treated with carbon tetrachloride.

N. Vermeulen, J. Commandeur, L. D. De Zwart, 1998, Toxicology and applied pharmacology.

Paracetamol (Acetaminophen)-Induced Toxicity: Molecular and Biochemical Mechanisms, Analogues and Protective Approaches

N. Vermeulen, J. Bessems, N P Vermeulen, 2001, Critical reviews in toxicology.

Correlation between the metabolism of hexobarbital and aminopyrine in vivo in rats.

N. Vermeulen, D. Breimer, M. van der Graaff, 1986, Xenobiotica; the fate of foreign compounds in biological systems.

Characterization of human cytochrome P450s involved in the bioactivation of tri-ortho-cresyl phosphate (ToCP).

N. Vermeulen, D. Noort, A. Fidder, 2015, Chemical research in toxicology.

Disposition of hexobarbital: 15 years of an intriguing model substrate.

N. Vermeulen, D. Breimer, M. van der Graaff, 1988, Drug metabolism reviews.

Stereospecific analysis of racemic hexobarbital in rat blood by enantioselective capillary gas chromatography.

N. Vermeulen, D. Breimer, M. van der Graaff, 1986, Journal of chromatography.

Selected ion monitoring analysis of pseudoracemic hexobarbital and its major metabolites in blood and urine of rats.

N. Vermeulen, D. Breimer, M. van der Graaff, 1985, Biomedical mass spectrometry.

Biosynthesis of a steroid metabolite by an engineered Rhodococcus erythropolis strain expressing a mutant cytochrome P450 BM3 enzyme

L. Dijkhuizen, N. Vermeulen, J. Commandeur, 2015, Applied Microbiology and Biotechnology.

Cytotoxicity of mitomycin C and adriamycin in freshly isolated rat hepatocytes: the role of cytochrome P450.

N. Vermeulen, J. Commandeur, H. Scheerens, 1994, Cancer research.

Inhibition of human glutathione S-transferases by curcumin and analogues

N. Vermeulen, J. Commandeur, E. Istyastono, 2009, Xenobiotica; the fate of foreign compounds in biological systems.

Genetic polymorphisms of human N-acetyltransferase, cytochrome P450, glutathione-S-transferase, and epoxide hydrolase enzymes: relevance to xenobiotic metabolism and toxicity.

N. Vermeulen, J. Commandeur, L. W. Wormhoudt, 1999, Critical reviews in toxicology.

In vitro inhibition of rat and human glutathione S-transferase isoenzymes by disulfiram and diethyldithiocarbamate.

N. Vermeulen, P. van Bladeren, J. Commandeur, 1996, Biochemical pharmacology.

Mutagenicity of halogenated and other substituted dinitrobenzenes in Salmonella typhimurium TA100 and derivatives deficient in glutathione (TA100/GSH-) and nitroreductase (TA100NR).

N. Vermeulen, P. van Bladeren, G. Mohn, 1987, Mutation research.

Inter-donor variability of phase I/phase II metabolism of three reference drugs in cryopreserved primary human hepatocytes in suspension and monolayer.

N. Vermeulen, Shalenie P. den Braver-Sewradj, J. Commandeur, 2016, Toxicology in vitro : an international journal published in association with BIBRA.

The metabolic fate of 1',2'-epoxyhexobarbital in the rat.

N. Vermeulen, D. Breimer, A. van der Gen, 1981, Xenobiotica; the fate of foreign compounds in biological systems.

The cytotoxicity of mitomycin C and adriamycin in genetically engineered V79 cell lines and freshly isolated rat hepatocytes.

H. Glatt, N. Vermeulen, A. Seidel, 1995, Chemico-biological interactions.

ACTIVATION OF AFLATOXIN BY INDUCIBLE CYTOCHROME-P-450 ISOENZYMES

N. Vermeulen, M. Herweijer, T. Bootsman, 1987 .

Urinary excretion of biomarkers for radical-induced damage in rats treated with NDMA or diquat and the effects of calcium carbimide co-administration.

N. Vermeulen, J. Commandeur, L. D. De Zwart, 1999, Chemico-biological interactions.

Urinary excretion of N-acetyl-S-allyl-L-cysteine upon garlic consumption by human volunteers

N. Vermeulen, P. Boogaard, B. D. de Rooij, 1996, Archives of Toxicology.

Managing the challenge of chemically reactive metabolites in drug development

Ian D. Wilson, Alan Boobis, Chris E. P. Goldring, 2011, Nature Reviews Drug Discovery.

Use of 19F-nuclear magnetic resonance and gas chromatography-electron capture detection in the quantitative analysis of fluorine-containing metabolites in urine of sevoflurane-anaesthetized patients

N. Vermeulen, U. Aypar, N P E Vermeulen, 2004, Xenobiotica; the fate of foreign compounds in biological systems.

Urinary lipid and protein oxidation products upon halothane, isoflurane, or sevoflurane anesthesia in humans: potential biomarkers for a subclinical nephrotoxicity

N. Vermeulen, G. Sahin, U. Aypar, 2013, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Human multidrug resistance protein 4 (MRP4) is a cellular efflux transporter for paracetamol glutathione and cysteine conjugates

N. Vermeulen, F. Russel, J. B. Koenderink, 2020, Archives of Toxicology.

Glutathione‐S‐transferase pi as a model protein for the characterisation of chemically reactive metabolites

N. Vermeulen, N. Kitteringham, B. K. Park, 2008, Proteomics.

Influence of allylisopropylacetamide and phenobarbital treatment on in vivo antipyrine metabolite formation in rats.

N. Vermeulen, D. Breimer, M. Teunissen, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

Influence of 9-hydroxyellipticine and 3-methylcholanthrene treatment on antipyrine metabolite formation in rats in vivo.

N. Vermeulen, D. Breimer, M. Teunissen, 1983, Xenobiotica; the fate of foreign compounds in biological systems.

Pharmacokinetics of lidocaine and bupivacaine following subarachnoid administration in surgical patients: simultaneous investigation of absorption and disposition kinetics using stable isotopes.

N. Vermeulen, D. Breimer, A. Burm, 1988 .

Automated high-performance liquid chromatographic determination of antipyrine and its main metabolites in plasma, saliva and urine, including 4,4'-dihydroxyantipyrine.

N. Vermeulen, D. Breimer, M. Teunissen, 1983, Journal of chromatography.

Antipyrine metabolite formation and excretion in patients with chronic renal failure

N. Vermeulen, I. Roots, D. Breimer, 2004, European Journal of Clinical Pharmacology.

ABSORPTION KINETICS OF LIDOCAINE AND BUPIVACAINE FOLLOWING EPIDURAL AND SUBARACHNOID ADMINISTRATION - A STUDY USING A STABLE ISOTOPE METHOD

N. Vermeulen, D. Breimer, A. Burm, 1986 .

Biotransformation of endocrine disrupting compounds by selected phase I and phase II enzymes--formation of estrogenic and chemically reactive metabolites by cytochromes P450 and sulfotransferases.

N. Vermeulen, J. Reinen, 2014, Current Medicinal Chemistry.

Drug toxicity profiling of a Saccharomyces cerevisiae deubiquitinase deletion panel shows that acetaminophen mimics tyrosine.

N. Vermeulen, F. van Leeuwen, M. van Dijk, 2018, Toxicology in vitro : an international journal published in association with BIBRA.

Active-site structure, binding and redox activity of the heme–thiolate enzyme CYP2D6 immobilized on coated Ag electrodes: a surface-enhanced resonance Raman scattering study

N. Vermeulen, P. Keizers, A. Bonifacio, 2007, JBIC Journal of Biological Inorganic Chemistry.

A refined substrate model for human cytochrome P450 2D6.

N. Vermeulen, M. D. de Groot, M J de Groot, 1997, Chemical research in toxicology.

Rapid on-line profiling of estrogen receptor binding metabolites of tamoxifen.

N. Vermeulen, J. Meerman, R. Ramautar, 2006, Journal of medicinal chemistry.

Binding of bufuralol, dextromethorphan, and 3,4-methylenedioxymethylamphetamine to wild-type and F120A mutant cytochrome P450 2D6 studied by resonance Raman spectroscopy.

N. Vermeulen, P. Keizers, A. Bonifacio, 2006, Biochemical and biophysical research communications.

Comparison of murine and human estrogen sulfotransferase inhibition in vitro and in silico—Implications for differences in activity, subunit dimerization and substrate inhibition

H. Glatt, N. Vermeulen, C. Oostenbrink, 2010, Molecular and Cellular Endocrinology.

Effects of oxygen radical scavengers on the inactivation of SS phi X174 DNA by the semi-quinone free radical of the antitumor agent etoposide.

J. Lankelma, N. Vermeulen, J. de Vries, 1990, Free radical research communications.

Linking cytochrome P450 enzymes from Mycobacterium tuberculosis to their cognate ferredoxin partners

N. Vermeulen, T. Grossmann, W. Bitter, 2018, Applied Microbiology and Biotechnology.

A preliminary 3D model for cytochrome P450 2D6 constructed by homology model building

Nico P. E. Vermeulen, Lucien M. H. Koymans, Gabriëlle M. Donné-Op den Kelder, 1993, J. Comput. Aided Mol. Des..

Characterization of enzyme activities and cofactors involved in bioactivation and bioinactivation of chemical carcinogens in the tester strains Escherichia coli K12 MX100 and Salmonella typhimurium LT2 TA100.

N. Vermeulen, J. Commandeur, J. Rueff, 1997, Mutagenesis.

Combining substrate dynamics, binding statistics, and energy barriers to rationalize regioselective hydroxylation of octane and lauric acid by CYP102A1 and mutants

N. Vermeulen, K. Feenstra, V. Urlacher, 2007, Protein science : a publication of the Protein Society.

Regioselective hydroxylation of debrisoquine by cytochrome P4502D6: implications for active site modelling

G. Tucker, N. Vermeulen, F. Blaney, 2000, Xenobiotica; the fate of foreign compounds in biological systems.

Route‐ and dose‐dependent pharmacokinetics of hexobarbitone in the rat: a re‐evaluation of the use of sleeping times in metabolic studies

N. Vermeulen, D. Breimer, M. Graaff, 1985, The Journal of pharmacy and pharmacology.

Enantioselective substrate binding in a monooxygenase protein model by molecular dynamics and docking.

A. Schmid, N. Vermeulen, K. Feenstra, 2006, Biophysical journal.

Heterologous Expression of Xenobiotic Mammalian-Metabolizing Enzymes in Mutagenicity Tester Bacteria: An Update and Practical Considerations

N. Vermeulen, R. Estabrook, J. Rueff, 2000, Critical reviews in toxicology.

MX100, a new Escherichia coli tester strain for use in genotoxicity studies.

N. Vermeulen, J. Rueff, P. Mesquita, 1996, Mutagenesis.

Endocrine disrupting chemicals-Linking internal exposure to vitellogenin levels and ovotestis in Abramis brama from Dutch surface waters.

N. Vermeulen, Mariana F. Fernández, M. Suter, 2010, Environmental toxicology and pharmacology.

Characterization of human cytochrome P450 mediated bioactivation of amodiaquine and its major metabolite N‐desethylamodiaquine

N. Vermeulen, J. Commandeur, Yongjie Zhang, 2017, British journal of clinical pharmacology.

A Comparative Linear Interaction Energy and MM/PBSA Study on SIRT1–Ligand Binding Free Energy Calculation

Eko Aditya Rifai, Marc van Dijk, Nico P. E. Vermeulen, 2019, J. Chem. Inf. Model..

Mass spectrometric identification of isocyanate-induced modifications of keratins in human skin.

N. Vermeulen, D. Noort, A. Hulst, 2015, Chemico-biological interactions.

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity. How to evaluate the risk of the S-EDCs?

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Journal of toxicology and environmental health. Part A.

Pharmacokinetics of pemoline in plasma, saliva and urine following oral administration.

N. Vermeulen, D. Breimer, M. Teunissen, 1979, British journal of clinical pharmacology.

Toxicological effects of bromobenzene and 2,2'-dichlorobiphenyl on the pond snail Lymnaea stagnalis: Histological stress in digestive gland cells

N. Vermeulen, M. Wilbrink, R. Zijl, 1990 .

Formation of estrogenic metabolites of benzo[a]pyrene and chrysene by cytochrome P450 activity and their combined and supra-maximal estrogenic activity.

N. Vermeulen, A. Seidel, J. Meerman, 2005, Environmental toxicology and pharmacology.

Functional characterization of eight human cytochrome P450 1A2 gene variants by recombinant protein expression

N. Vermeulen, M. E. Sousa, J. Lastdrager, 2010, The Pharmacogenomics Journal.

Inter-individual variability in the oxidation of 1,2-dibromoethane: use of heterologously expressed human cytochrome P450 and human liver microsomes.

P. Beaune, N. Vermeulen, P. van Bladeren, 1996, Chemico-biological interactions.

Homology modeling of rat and human cytochrome P450 2D (CYP2D) isoforms and computational rationalization of experimental ligand-binding specificities.

Nico P E Vermeulen, Jennifer Venhorst, J. Venhorst, 2003, Journal of medicinal chemistry.

Assay of pemoline in human plasma, saliva and urine by capillary gas chromatography with nitrogen-selective detection.

N. Vermeulen, D. Breimer, M. Teunissen, 1978, Journal of chromatography.

ACCELERATION OF FREE RELEASE STATIC COATING OF CAPILLARY COLUMNS BY THE PRESENCE OF POLAR-SOLVENTS IN THE COATING SOLUTION - A THEORETICAL-STUDY

N. Vermeulen, B. Xu, 1988 .

Simultaneous determination of blood concentrations of methohexital and its hydroxy metabolite by gas chromatography and identification of 4'-hydroxymethohexital by combined gas--liquid chromatography--mass spectrometry.

N. Vermeulen, D. Breimer, S. Heusler, 1981, Journal of chromatography.

Gas chromatographic determination of pemoline as 5-phenyl-2,4-oxazolidinedione in human urine.

N. Vermeulen, D. Breimer, D. D. de Roode, 1977, Journal of chromatography.

Diclofenac inhibits tumor necrosis factor‐α‐induced nuclear factor‐κB activation causing synergistic hepatocyte apoptosis

Bob van de Water, Sanja Dragovic, Lisa Fredriksson, 2011, Hepatology.

Modeling and molecular dynamics of glutamine transaminase K/cysteine conjugate beta-lyase.

J. Venhorst, N. Vermeulen, J. Commandeur, 2003, Journal of molecular graphics & modelling.

Regio‐ and Stereoselective Hydroxylation of Optically Active α‐Ionone Enantiomers by Engineered Cytochrome P450 BM3 Mutants

S. D. Beer, N. Vermeulen, D. Geerke, 2012 .

Expression of human cytochrome P450 1A2 in Escherichia coli: a system for biotransformation and genotoxicity studies of chemical carcinogens.

N. Vermeulen, J. Rueff, M. Kranendonk, 1998, Mutagenesis.

The role of phenylalanine 483 in cytochrome P450 2D6 is strongly substrate dependent.

M. Ingelman-Sundberg, N. Vermeulen, P. Keizers, 2005, Biochemical pharmacology.

Influence of phenylalanine 120 on cytochrome P450 2D6 catalytic selectivity and regiospecificity: crucial role in 7-methoxy-4-(aminomethyl)-coumarin metabolism.

N. Vermeulen, P. Keizers, C. de Graaf, 2004, Biochemical pharmacology.

A physiologically-based pharmacokinetic(PB-PK) model for ethylene dibromide: relevance of extrahepatic metabolism.

N. Vermeulen, P. van Bladeren, J. Hayes, 2000, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Environmental toxicology and pharmacology.

Bioactivation of N-substituted N′-(4-imidazole-ethyl)thioureas by human FMO1 and FMO3

N. Vermeulen, A. Rettie, R. Onderwater, 2006, Xenobiotica; the fate of foreign compounds in biological systems.

Modeling the active sites of cytochrome P450s and glutathione S-transferases, two of the most important biotransformation enzymes.

N. Vermeulen, M. D. de Groot, N P Vermeulen, 1997, Drug metabolism reviews.

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.

N. Vermeulen, Jolanda van Leeuwen, J. Vos, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Effect of UGT2B7*2 and CYP2C8*4 polymorphisms on diclofenac metabolism.

N. Vermeulen, J. Commandeur, Stefan J. Dekker, 2018, Toxicology letters.

Hexobarbital-1',2'-epoxide: a possible intermediate in the metabolism of hexobarbital.

N. Vermeulen, P. van Bladeren, D. Breimer, 1978, Biochemical pharmacology.

Comparative toxicokinetics of 2,2′- and 4,4′-dichlorobiphenyls in the pond snailLymnaea stagnalis (L.)

N. Vermeulen, M. Wilbrink, M. Treskes, 1990, Archives of environmental contamination and toxicology.

Are Automated Molecular Dynamics Simulations and Binding Free Energy Calculations Realistic Tools in Lead Optimization? An Evaluation of the Linear Interaction Energy (LIE) Method

Chris Oostenbrink, Nico P. E. Vermeulen, Eva Stjernschantz, 2006, J. Chem. Inf. Model..

The inhibitory effect of newly synthesized ethnyl- derivatives on the activity of cytochrome P 450 isoenzymes in rat liver microsomes in-vitro

N. Vermeulen, A. Goeptar, Az. Teleb, 2014 .

Subunits Rip1p and Cox9p of the respiratory chain contribute to diclofenac-induced mitochondrial dysfunction.

M. Luttik, N. Vermeulen, G. Smits, 2011, Microbiology.

Ab initio calculations on iron-porphyrin model systems for intermediates in the oxidative cycle of cytochrome P450s

Nico P. E. Vermeulen, H. Maarten Vinkers, Joop H. van Lenthe, 1998, J. Comput. Aided Mol. Des..

Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450.

Chris Oostenbrink, Nico P E Vermeulen, Eva Stjernschantz, 2008, Expert opinion on drug metabolism & toxicology.

Trimethoprim: novel reactive intermediates and bioactivation pathways by cytochrome p450s.

N. Vermeulen, H. Irth, W. Niessen, 2008, Chemical research in toxicology.

Heterotropic and homotropic cooperativity by a drug-metabolising mutant of cytochrome P450 BM3.

N. Vermeulen, B. V. van Vugt-Lussenburg, J. Commandeur, 2006, Biochemical and biophysical research communications.

Metabolism of l-cysteine S-conjugates and N-(trideuteroacetyl)-l-cysteineS-conjugates of four fluoroethylenes in the rat

N. Vermeulen, J. Commandeur, G. J. Stijntjes, 1991 .

Prediction of drug metabolism: the case of cytochrome P450 2D6.

Nico P. E. Vermeulen, N. Vermeulen, 2003, Current topics in medicinal chemistry.

CYTOTOXIC AND CYTOPROTECTIVE ACTIVITIES OF CURCUMIN EFFECTS ON PARACETAMOL INDUCED CYTOTOXICITY, LIPID GLUTATHIONE DEPLETION IN RAT HEPATOCYTES

N. Vermeulen, I. A. Donatus, Sardjoko, 1990 .

Human exposure to synthetic endocrine disrupting chemicals (S-EDCs) is generally negligible as compared to natural compounds with higher or comparable endocrine activity: how to evaluate the risk of the S-EDCs?

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Archives of Toxicology.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Toxicology letters.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Toxicology in vitro : an international journal published in association with BIBRA.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Chemico-biological interactions.

Evaluation of a Multi-parameter Biomarker Set for Oxidative Damage in Man: Increased Urinary Excretion of Lipid, Protein and DNA Oxidation Products after One Hour of Exercise

N. Vermeulen, J. Meerman, Berry J van Holland, 2004, Free radical research.

Free energies of binding of R- and S-propranolol to wild-type and F483A mutant cytochrome P450 2D6 from molecular dynamics simulations

N. Vermeulen, C. Oostenbrink, P. Keizers, 2007, European Biophysics Journal.

Synthesis and acid‐ and base‐catalyzed reactions of hexobarbital 1′,2′‐epoxide and heptabarbital 1′,2′‐epoxide

N. Vermeulen, D. Breimer, B. Bakker, 2010 .

Direct comparison of UDP‐glucuronosyltransferase and cytochrome P450 activities in human liver microsomes, plated and suspended primary human hepatocytes from five liver donors

N. Vermeulen, P. Bachellier, Shalenie P. den Braver-Sewradj, 2017, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

A predictive model for substrates of cytochrome P450-debrisoquine (2D6).

S A van Acker, L. Koymans, N. Vermeulen, 1992, Chemical research in toxicology.

Structure-activity relationships for the glutathione conjugation of 2-substituted 1-chloro-4-nitrobenzenes by rat glutathione S-transferase 4-4.

N. Vermeulen, M. D. de Groot, E. M. van der Aar, 1996, Chemical research in toxicology.

Glutathione S-transferases : structure, function and clinical implications

N. Vermeulen, 2014 .

Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques

Olivier Taboureau, Chris Oostenbrink, Poongavanam Vasanthanathan, 2009, Drug Metabolism and Disposition.

Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques

Olivier Taboureau, Chris Oostenbrink, Poongavanam Vasanthanathan, 2009, Drug Metabolism and Disposition.

Protective effects of lobenzarit against allyl alcohol-induced hepatotoxicity in mice and rats.

N. Vermeulen, J. Commandeur, R. González, 1997, Environmental toxicology and pharmacology.

Altered spin state equilibrium in the T309V mutant of cytochrome P450 2D6: a spectroscopic and computational study

K. Lammertsma, N. Vermeulen, P. Keizers, 2007, JBIC Journal of Biological Inorganic Chemistry.

Metabolic regio- and stereoselectivity of cytochrome P450 2D6 towards 3,4-methylenedioxy-N-alkylamphetamines: in silico predictions and experimental validation.

Chris de Graaf, Chris Oostenbrink, K. Anton Feenstra, 2005, Journal of medicinal chemistry.

Computational prediction of drug binding and rationalisation of selectivity towards cytochromes P450

Chris Oostenbrink, Eva Stjernschantz, Nico P. E. Vermeulen, 2008 .

Binding of 7-methoxy-4-(aminomethyl)-coumarin to wild-type and W128F mutant cytochrome P450 2D6 studied by time-resolved fluorescence spectroscopy.

N. Vermeulen, C. Oostenbrink, P. Keizers, 2006, The Biochemical journal.

Selective whole-cell biosynthesis of the designer drug metabolites 15- or 16-betahydroxynorethisterone by engineered Cytochrome P450 BM3 mutants

M. Honing, N. Vermeulen, J. Commandeur, 2015 .

Binding free energy predictions of farnesoid X receptor (FXR) agonists using a linear interaction energy (LIE) approach with reliability estimation: application to the D3R Grand Challenge 2

Marc van Dijk, Nico P. E. Vermeulen, Daan P. Geerke, 2017, Journal of Computer-Aided Molecular Design.

Study on the cytochrome P-450- and glutathione-dependent biotransformation of trichloroethylene in humans

S. Kežić, N. Vermeulen, H. Veulemans, 2001, International archives of occupational and environmental health.

Involvement of the Pleiotropic Drug Resistance Response, Protein Kinase C Signaling, and Altered Zinc Homeostasis in Resistance of Saccharomyces cerevisiae to Diclofenac

Nico P. E. Vermeulen, N. Vermeulen, Jolanda van Leeuwen, 2011, Applied and Environmental Microbiology.

Effects of dihalogenated biphenyls on various functional parameters in the pond snail Lymnaea stagnalis

N. Vermeulen, C. Janse, T. A. Vlieger, 1987 .

The use of human in vitro metabolic parameters to explore the risk assessment of hazardous compounds: the case of ethylene dibromide.

P. Beaune, N. Vermeulen, P. van Bladeren, 1997, Toxicology and applied pharmacology.

Influence of N-substitution of 7-methoxy-4-(aminomethyl)-coumarin on cytochrome P450 metabolism and selectivity.

J. Venhorst, N. Vermeulen, J. Meerman, 2000, Drug metabolism and disposition: the biological fate of chemicals.

Design, synthesis, and characterization of 7-methoxy-4-(aminomethyl)coumarin as a novel and selective cytochrome P450 2D6 substrate suitable for high-throughput screening.

J. Venhorst, N. Vermeulen, J. Commandeur, 1999, Chemical research in toxicology.

Towards Automated Binding Affinity Prediction Using an Iterative Linear Interaction Energy Approach

Daan P. Geerke, René Pool, C. Ruben Vosmeer, 2014, International journal of molecular sciences.

LC-Tandem MS Detection of Covalent Binding of Acetaminophen to Human Serum Albumin.

Daan, N. Vermeulen, A. Hulst, 2007 .

A three-dimensional protein model for human cytochrome P450 2D6 based on the crystal structures of P450 101, P450 102, and P450 108.

N. Vermeulen, M. D. de Groot, M J de Groot, 1996, Chemical research in toxicology.

On-line Formation, Separation, and Estrogen Receptor Affinity Screening of Cytochrome P450-Derived Metabolites of Selective Estrogen Receptor Modulators

N. Vermeulen, J. Kool, H. Irth, 2006, Drug Metabolism and Disposition.

Extension of a predictive substrate model for human cytochrome P4502D6.

J. G. Snijders, N. Vermeulen, M. D. de Groot, 1997, Xenobiotica; the fate of foreign compounds in biological systems.

Free Energy Calculations Give Insight into the Stereoselective Hydroxylation of α-Ionones by Engineered Cytochrome P450 BM3 Mutants

Chris Oostenbrink, Daan P. Geerke, Nico P. E. Vermeulen, 2012, J. Chem. Inf. Model..

The role and application of in silico docking in chemical genomics research.

Chris de Graaf, Rob Leurs, Nico P E Vermeulen, 2005, Methods in molecular biology.

The use of macroporous microcarriers for the large-scale growth of V79 cells genetically designed to express single human cytochrome P450 isoenzymes and for the characterization of the expressed cytochrome P450.

N. Vermeulen, J. Doehmer, J. Commandeur, 1996, Protein expression and purification.

Cytochrome P450-drug interactions: Computational binding mode and affinity predictions in CYP2D6

N. Vermeulen, K. Feenstra, C. Graaf, 2006 .

Uptake–toxicity relationships of a series of N-substituted N′-(4-imidazole-ethyl)thiourea in precision-cut rat liver slices

N. Vermeulen, J. Commandeur, M. Rooseboom, 2005, Xenobiotica; the fate of foreign compounds in biological systems.

Reversed-phase liquid chromatography coupled on-line to estrogen receptor bioaffinity detection based on fluorescence polarization

N. Vermeulen, J. Kool, Jelle Reinen, 2008, Analytical and bioanalytical chemistry.

Linear Interaction Energy Based Prediction of Cytochrome P450 1A2 Binding Affinities with Reliability Estimation

Daan P. Geerke, Luigi Capoferri, Manuel Pastor, 2015, PloS one.

Virtual Screening and Prediction of Site of Metabolism for Cytochrome P450 1A2 Ligands

Olivier Taboureau, Jozef Hritz, Chris Oostenbrink, 2009, J. Chem. Inf. Model..

Classification of Cytochrome P450 1A2 Inhibitors and Noninhibitors by Machine Learning Techniques

N. Vermeulen, C. Oostenbrink, O. Taboureau, 2009, Drug Metabolism and Disposition.

Metabolic profiling of endocrine-disrupting compounds by on-line cytochrome p450 bioreaction coupled to on-line receptor affinity screening.

Jeroen Kool, N. Vermeulen, J. Meerman, 2007, Chemical research in toxicology.

G. B. Gori, D. Dietrich, N. Vermeulen, 2020, Journal of toxicology and environmental health. Part A.

Dose-dependent pharmacokinetics of zoxazolamine in the rat.

N. Vermeulen, D. Breimer, M. van der Graaff, 1986, Drug metabolism and disposition: the biological fate of chemicals.

The role of biotransformation in the estrogenicity of xenobiotics

H. Glatt, N. Vermeulen, C. Oostenbrink, 2010 .

Reduction of cisplatin nephrotoxicity by sodium selenite. Lack of interaction at the pharmacokinetic level of both compounds.

N. Vermeulen, J. Mcvie, G. Los, 1993, Drug metabolism and disposition: the biological fate of chemicals.

Differential involvement of mitochondrial dysfunction, cytochrome P450 activity, and active transport in the toxicity of structurally related NSAIDs.

N. Vermeulen, Jolanda van Leeuwen, J. C. Vos, 2012, Toxicology in vitro : an international journal published in association with BIBRA.

Evaluation of a novel high-throughput assay for cytochrome P450 2D6 using 7-methoxy-4-(aminomethyl)-coumarin.

J. Venhorst, N. Vermeulen, J. Meerman, 2000, European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences.

Mercapturic acids as biomarkers of exposure to electrophilic chemicals:applications to environmental and industrial chemicals.

N. Vermeulen, J. Commandeur, B. M. Rooij, 1998, Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals.

Characterization of Human Cytochrome P450s Involved in the Bioactivation of Clozapine (vol 41, pg 651, 2013)

M. Ingelman-Sundberg, N. Vermeulen, J. Commandeur, 2013 .

Role of Residue 87 in the Activity and Regioselectivity of Clozapine Metabolism by Drug-Metabolizing CYP102A1 M11H: Application for Structural Characterization of Clozapine GSH Conjugates

N. Vermeulen, J. Commandeur, F. D. de Kanter, 2011, Drug Metabolism and Disposition.

Microsoft Word-6960036-file00

N. Vermeulen, C. Oostenbrink, O. Taboureau, 2008 .

The role of biotransformation in the estrogenicity of xenobiotics

N. Vermeulen, Suilan Ferman, E. Vottero, 2010 .