T. Peat

发表

Crystallization: digging into the past to learn lessons for the future.

J. Newman, Vincent Fazio, T. Peat, 2015, Methods in molecular biology.

Class‐directed structure determination: Foundation for a protein structure initiative

J. Newman, T. Peat, T. Terwilliger, 1998, Protein science : a publication of the Protein Society.

What's in a Name? Moving Towards a Limited Vocabulary for Macromolecular Crystallisation

J. Newman, T. Peat, G. P. Savage, 2014 .

Structural Basis for a New Mechanism of Inhibition of H I V-1 Integrase Identified by Fragment Screening and Structure-Based Design

J. Newman, T. Peat, J. Deadman, 2011, Antiviral chemistry & chemotherapy.

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor

W. Baumeister, P. Sexton, A. Christopoulos, 2018, Nature.

Structural analysis of a set of proteins resulting from a bacterial genomics project

B. Laubert, J. M. Sauder, K. Gajiwala, 2005, Proteins.

Fragment Screening for the Modelling Community: SPR, ITC, and Crystallography

Thomas S. Peat, Olan Dolezal, Janet Newman, 2013 .

Structure of translation initiation factor 5A from Pyrobaculum aerophilum at 1.75 A resolution.

T C Terwilliger, J Berendzen, J. Newman, 1998, Structure.

Crystal Structures of Novel Allosteric Peptide Inhibitors of HIV Integrase Identify New Interactions at the LEDGF Binding Site

J. Newman, T. Peat, J. Deadman, 2011, Chembiochem : a European journal of chemical biology.

A double emulsion microfluidic platform for in vitro GFP expression

J. Oakeshott, T. Peat, B. Sexton, 2011 .

Native State Mass Spectrometry, Surface Plasmon Resonance, and X-ray Crystallography Correlate Strongly as a Fragment Screening Combination.

T. Peat, B. Ren, O. Dolezal, 2016, Journal of medicinal chemistry.

Parallel Screening of Low Molecular Weight Fragment Libraries

Olan Dolezal, Janet Newman, Jerome Wielens, 2013, Journal of biomolecular screening.

Unexpected Isomerisation of a Fragment Analogue During Fragment-Based Screening of HIV Integrase Catalytic Core Domain

T. Peat, J. Deadman, G. P. Savage, 2015 .

Construction of the CSIRO Fragment Library

T. Peat, G. P. Savage, O. Dolezal, 2013 .

The structure of vanin 1: a key enzyme linking metabolic disease and inflammation.

Janet Newman, Thomas S Peat, J. Newman, 2014, Acta crystallographica. Section D, Biological crystallography.

Structure and function of ecdysone receptors - interactions with ecdysteroids and synthetic agonists

D. Winkler, T. Peat, M. Lawrence, 2012 .

Crystallization and preliminary X-ray analysis of the complexes between a Fab and two forms of human insulin-like growth factor II.

E. H. Cohen, J. Newman, T. Peat, 2009, Acta crystallographica. Section F, Structural biology and crystallization communications.

Characterization of the novel broad-spectrum kinase inhibitor CTx-0294885 as an affinity reagent for mass spectrometry-based kinome profiling.

Naveid A Ali, M. de Silva, T. Peat, 2013, Journal of proteome research.

The evolving story of AtzT, a periplasmic binding protein

J. Newman, T. Peat, T. Nebl, 2019, Acta crystallographica. Section D, Structural biology.

Crystal structures of human ENPP1 in apo and bound forms

J. Newman, T. Peat, O. Dolezal, 2020, Acta crystallographica. Section D, Structural biology.

Structures of the transcriptional regulator BgaR, a lactose sensor.

J. Newman, T. Peat, T. Nebl, 2019, Acta crystallographica. Section D, Structural biology.

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme

J. Newman, T. Peat, Jian-wei Liu, 2018, The Journal of Biological Chemistry.

A novel decarboxylating amidohydrolase involved in avoiding metabolic dead ends during cyanuric acid catabolism in Pseudomonas sp. strain ADP

J. Newman, T. Peat, C. Scott, 2018, PloS one.

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

J. Newman, T. Peat, C. Scott, 2017, Acta crystallographica. Section F, Structural biology communications.

X-ray crystal structure of a malonate-semialdehyde dehydrogenase from Pseudomonas sp. strain AAC.

J. Newman, T. Peat, C. Scott, 2017, Acta crystallographica. Section F, Structural biology communications.

The X-ray crystal structure of the N-terminal domain of Ssr4, a Schizosaccharomyces pombe chromatin-remodelling protein

J. Newman, T. Peat, T. Nebl, 2020, Acta crystallographica. Section F, Structural biology communications.

X-ray crystallography of Epacadostat in adduct with Carbonic Anhydrase IX.

C. Supuran, T. Peat, A. Angeli, 2020, Bioorganic chemistry.

HBO1 is required for the maintenance of leukaemia stem cells

Linden J. Gearing, O. Dovey, S. Dawson, 2019 .

Synthesis of novel tellurides bearing benzensulfonamide moiety as carbonic anhydrase inhibitors with antitumor activity.

C. Supuran, T. Peat, C. Ghelardini, 2019, European journal of medicinal chemistry.

Benzensulfonamides bearing spyrohydantoin moieties act as potent inhibitors of human carbonic anhydrases II and VII and show neuropathic pain attenuating effects.

C. Supuran, T. Peat, C. Ghelardini, 2019, European journal of medicinal chemistry.

Design, synthesis and X-ray crystallography of selenides bearing benzenesulfonamide moiety with neuropathic pain modulating effects.

C. Supuran, T. Peat, C. Ghelardini, 2018, European journal of medicinal chemistry.

Synthesis, structure and bioactivity of primary sulfamate-containing natural products.

C. Supuran, T. Peat, Silvia Bua, 2018, Bioorganic & medicinal chemistry letters.

Crystallization and preliminary X-ray analysis of 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

J. Newman, T. Peat, R. Fernley, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

An unexpected vestigial protein complex reveals the evolutionary origins of an s-triazine catabolic enzyme

J. Newman, T. Peat, Jian-wei Liu, 2018, The Journal of Biological Chemistry.

Structural basis for the allosteric regulation of the SbtA bicarbonate transporter by the PII-like protein, SbtB, from Cyanobium sp. PCC7001.

T. Peat, C. Jackson, L. Wey, 2019, Biochemistry.

Structural and biochemical characterization of the biuret hydrolase (BiuH) from the cyanuric acid catabolism pathway of Rhizobium leguminasorum bv. viciae 3841

J. Newman, T. Peat, C. Scott, 2018, PloS one.

A (cid:2) -Alanine Catabolism Pathway Containing a Highly Promiscuous (cid:3) -Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC

J. Newman, T. Peat, C. Scott, 2016 .

Multivalency drives the neutralizing activity of antibodies against the Plasmodium falciparum circumsporozoite protein

Joshua A. Mitchell, T. Peat, C. Jackson, 2017, bioRxiv.

Production and crystallization of a selenomethionyl variant of UmuD′, an Echerichia coli SOS response protein

E. G. Frank, R. Woodgate, T. Peat, 1996 .

Characterization of crystals of the thermostable DNA polymerase I from thermus aquaticus

T. Peat, W. Hendrickson, H. Krishna Murthy, 1995, Proteins.

From information management to protein annotation: preparing protein structures for drug discovery.

J. Newman, T. Peat, E. de La Fortelle, 2002, Acta crystallographica. Section D, Biological crystallography.

Molecular characterization of cyanobacterial short‐chain prenyltransferases and discovery of a novel GGPP phosphatase

J. Newman, T. Peat, B. Ebert, 2022, The FEBS journal.

An Unusual Natural Product Primary Sulfonamide: Synthesis, Carbonic Anhydrase Inhibition, and Protein X-ray Structures of Psammaplin C.

C. Supuran, T. Peat, D. Vullo, 2016, Journal of medicinal chemistry.

Discovery of New Selenoureido Analogues of 4-(4-Fluorophenylureido)benzenesulfonamide as Carbonic Anhydrase Inhibitors.

C. Supuran, T. Peat, C. Ghelardini, 2017, ACS medicinal chemistry letters.

Crystallization of an apo form of human arginase: using all the tools in the toolbox simultaneously.

J. Newman, T. Peat, C. Strickland, 2011, Acta crystallographica. Section F, Structural biology and crystallization communications.

Structural and Functional Basis of Resistance to Neuraminidase Inhibitors of Influenza B Viruses†

Thomas S. Peat, Janet Newman, Takehiko Saito, 2010, Journal of medicinal chemistry.

High-Resolution X-Ray Structures of Two Functionally Distinct Members of the Cyclic Amide Hydrolase Family of Toblerone Fold Enzymes

J. Newman, T. Peat, C. Scott, 2017, Applied and Environmental Microbiology.

X-Ray Structure and Mutagenesis Studies of the N-Isopropylammelide Isopropylaminohydrolase, AtzC

J. Newman, T. Peat, A. Warden, 2015, PloS one.

The structure of the hexameric atrazine chlorohydrolase AtzA

J. Newman, T. Peat, A. Warden, 2015, Acta crystallographica. Section D, Biological crystallography.

X-Ray Structure of the Amidase Domain of AtzF, the Allophanate Hydrolase from the Cyanuric Acid-Mineralizing Multienzyme Complex

P. M. Campbell, J. Newman, T. Peat, 2014, Applied and Environmental Microbiology.

Structural Basis for the Selective Binding of Inhibitors to 6-Hydroxymethyl-7,8-dihydropterin Pyrophosphokinase from Staphylococcus aureus and Escherichia coli.

J. Baell, Zhong-Chang Wang, T. Peat, 2016, Journal of medicinal chemistry.

Structure of S. aureus HPPK and the Discovery of a New Substrate Site Inhibitor

J. Newman, T. Peat, R. Fernley, 2012, PloS one.

Identification and characterization of two families of F420H2-dependent reductases from Mycobacteria that catalyse aflatoxin degradation

J. Oakeshott, P. M. Campbell, R. Russell, 2010, Molecular microbiology.

Evaluating Protic Ionic Liquids as Protein Crystallization Additives

Danielle F. Kennedy, Thomas S. Peat, Janet Newman, 2011 .

Reverse engineering: transaminase biocatalyst development using ancestral sequence reconstruction

Thomas S. Peat, Janet Newman, Subha Kalyaanamoorthy, 2017 .

A β-Alanine Catabolism Pathway Containing a Highly Promiscuous ω-Transaminase in the 12-Aminododecanate-Degrading Pseudomonas sp. Strain AAC

J. Newman, T. Peat, C. Scott, 2016, Applied and Environmental Microbiology.

Crystal Structure of an Indole-3-Acetic Acid Amido Synthetase from Grapevine Involved in Auxin Homeostasis[W]

J. Newman, T. Peat, N. Cowieson, 2012, Plant Cell.

Identification of a New Zinc Binding Chemotype by Fragment Screening.

T. Peat, B. Ren, O. Dolezal, 2017, Journal of medicinal chemistry.

Azidothymidine “Clicked” into 1,2,3-Triazoles: First Report on Carbonic Anhydrase–Telomerase Dual-Hybrid Inhibitors

S. Carradori, C. Supuran, T. Peat, 2020, Journal of medicinal chemistry.

Small Molecule Inhibitors of the LEDGF Site of Human Immunodeficiency Virus Integrase Identified by Fragment Screening and Structure Based Design

Thomas S. Peat, Olan Dolezal, Janet Newman, 2012, PloS one.

T-dependent B cell responses to Plasmodium induce antibodies that form a high-avidity multivalent complex with the circumsporozoite protein

Joshua A. Mitchell, T. Peat, C. Jackson, 2017, PLoS pathogens.

Cyclic secondary sulfonamides: unusually good inhibitors of cancer-related carbonic anhydrase enzymes.

C. Supuran, T. Peat, D. Vullo, 2014, Journal of medicinal chemistry.

Structural characterization of a novel monotreme-specific protein with antimicrobial activity from the milk of the platypus.

J. Newman, T. Peat, K. Nicholas, 2018, Acta crystallographica. Section F, Structural biology communications.

On the need for an international effort to capture, share and use crystallization screening data

Roger A. Sayle, David Lovell, Thomas S. Peat, 2012, Acta crystallographica. Section F, Structural biology and crystallization communications.

The UmuD' protein filament and its potential role in damage induced mutagenesis.

E. G. Frank, R. Woodgate, T. Peat, 1996, Structure.

Structure-guided selection of puromycin N-acetyltransferase mutants with enhanced selection stringency for deriving mammalian cell lines expressing recombinant proteins

J. Newman, T. Peat, S. Nuttall, 2021, Scientific Reports.

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

Nghi Nguyen, Thomas S. Peat, Olan Dolezal, 2018, Nature.

A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo

Thomas S. Peat, Olan Dolezal, Janet Newman, 2010, Molecular Cancer Therapeutics.

Discovery of potent dual-tailed benzenesulfonamide inhibitors of human carbonic anhydrases im-plicated in glaucoma and in vivo profiling of their intraocular pressure lowering action.

C. Supuran, E. Masini, T. Peat, 2020, Journal of medicinal chemistry.

Carbonic anhydrase inhibitors with dual-tail moieties to match the hydrophobic and hydrophilic halves of the carbonic anhydrase active site.

C. Supuran, T. Peat, D. Vullo, 2015, Journal of medicinal chemistry.

An Efficient High-Throughput Screening Method for MYST Family Acetyltransferases, a New Class of Epigenetic Drug Targets

George Nikolakopoulos, Olan Dolezal, Thomas S Peat, 2011, Journal of biomolecular screening.

Practical Aspects of the SAMPL Challenge: Providing an Extensive Experimental Data Set for the Modeling Community

Thomas S. Peat, Janet Newman, Kim Branson, 2009, Journal of biomolecular screening.

The 1.59 Å resolution crystal structure of TM0096, a flavin mononucleotide binding protein from Thermotoga maritima

K. Gajiwala, T. Peat, S. Buchanan, 2004, Proteins.

Rational engineering of a mesohalophilic carbonic anhydrase to an extreme halotolerant biocatalyst

Shane A. Seabrook, J. Newman, T. Peat, 2015, Nature Communications.

A double-emulsion microfluidic platform for in vitro green fluorescent protein expression

Thomas S. Peat, Nan Wu, John G. Oakeshott, 2011 .

Inhibitors of histone acetyltransferases KAT6A/B induce senescence and arrest tumour growth

A. Strasser, G. Smyth, J. Baell, 2018, Nature.

A PMMA microfluidic droplet platform for in vitro protein expression using crude E. coli S30 extract.

B A Sexton, J. Oakeshott, T. Peat, 2009, Lab on a chip.

Intermolecular cleavage by UmuD-like enzymes: identification of residues required for cleavage and substrate specificity.

R. Woodgate, T. Peat, A. Levine, 1999, Journal of molecular biology.

Structural and biochemical analyses of a Clostridium perfringens sortase D transpeptidase

Shane A. Seabrook, T. Peat, R. Suryadinata, 2015, Acta crystallographica. Section D, Biological crystallography.

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

C. Supuran, T. Peat, T. Nebl, 2021, Molecules.

The C6 Web Tool: A Resource for the Rational Selection of Crystallization Conditions

Thomas S. Peat, Janet Newman, Vincent J. Fazio, 2010 .

Tapping the Protein Data Bank for crystallization information.

Janet Newman, Thomas S Peat, Jon A Christopher, 2005, Acta crystallographica. Section D, Biological crystallography.

Fragment Screening on Staphylococcus aureus HPPK – a Folate Pathway Target

T. Peat, O. Dolezal, J. Swarbrick, 2013 .

Enzyme Assay in Microfluidics

Thomas S. Peat, Florian Lapierre, Y Gao, 2014 .

Bacterial catabolism of s-triazine herbicides: biochemistry, evolution and application.

J. Newman, T. Peat, C. Jackson, 2020, Advances in microbial physiology.

Nitrate in the active site of protein tyrosine phosphatase 1B is a putative mimetic of the transition state.

J. Newman, T. Peat, P. Kenny, 2014, Acta crystallographica. Section D, Biological crystallography.

A nondenaturing purification scheme for the DNA-binding domain of poly(ADP-ribose) polymerase, a structure-specific DNA-binding protein.

J. Newman, T. Peat, T. Terwilliger, 1998, Protein expression and purification.

Cyanuric acid hydrolase: evolutionary innovation by structural concatenation

J. Newman, T. Peat, N. Cowieson, 2013, Molecular microbiology.

How to fabricate robust microfluidic systems for a dollar

Neil R. Cameron, Thomas S. Peat, Yonggang Zhu, 2013, Smart Materials, Nano-, and Micro- Smart Systems.

Exploring the Chemical Space around 8-Mercaptoguanine as a Route to New Inhibitors of the Folate Biosynthesis Enzyme HPPK

J. Newman, T. Peat, O. Dolezal, 2013, PloS one.

Lipidic Cubic Phase-Induced Membrane Protein Crystallization: Interplay Between Lipid Molecular Structure, Mesophase Structure and Properties, and Crystallogenesis

C. Drummond, E. Landau, J. Newman, 2017 .

The nanoscience behind the art of in-meso crystallization of membrane proteins.

C. Drummond, J. Newman, T. Peat, 2017, Nanoscale.

A new crystal form of human vascular adhesion protein 1.

J. Newman, T. Peat, J. Guss, 2010, Acta crystallographica. Section F, Structural biology and crystallization communications.

Fragment screening for a protein-protein interaction inhibitor to WDR5

J. Newman, T. Peat, O. Dolezal, 2019, Structural dynamics.

Design of a methotrexate-controlled chemical dimerization system and its use in bio-electronic devices

E. Katz, J. Newman, T. Peat, 2021, Nature Communications.

Solution structure of Pyrobaculum aerophilum DsrC, an archaeal homologue of the gamma subunit of dissimilatory sulfite reductase.

T. Peat, T. Terwilliger, G. Waldo, 2001, European journal of biochemistry.

Interrogating HIV integrase for compounds that bind- a SAMPL challenge

Thomas S. Peat, Olan Dolezal, Janet Newman, 2013, Journal of Computer-Aided Molecular Design.

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

M. Field, J. Oakeshott, R. Russell, 2014, Applied and Environmental Microbiology.

Crystallization reports are the backbone of Acta Cryst. F, but do they have any spine?

Janet Newman, Bevan Marshall, Vincent J Fazio, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Intramolecular oxidative deselenization of acylselenoureas: a facile synthesis of benzoxazole amides and carbonic anhydrase inhibitors.

C. Supuran, T. Peat, A. Angeli, 2016, Organic & biomolecular chemistry.

Crystal structure of YIGZ, a conserved hypothetical protein from Escherichia coli k12 with a novel fold

K. Gajiwala, T. Peat, S. Buchanan, 2004, Proteins.

Some of the most interesting CASP11 targets through the eyes of their authors

Victor Seguritan, Thomas S. Peat, Forest Rohwer, 2015, Proteins.

Dialysis against a Solution Containing 50 Mm Na 2 so 4 and 1 Mm Edta, with the Ph Adjusted to 8.2, Using 1 N H 2 so 4

T C Terwilliger, J. Newman, T. Peat, 1999 .

Expression, purification, crystallization and preliminary X-ray diffraction analysis of a lactococcal bacteriophage small terminase subunit.

T. Peat, W. McKinstry, B. Ren, 2013, Acta crystallographica. Section F, Structural biology and crystallization communications.

Phoenito experiments: combining the strengths of commercial crystallization automation.

Janet Newman, Tam M Pham, Thomas S Peat, 2008, Acta crystallographica. Section F, Structural biology and crystallization communications.

Design, Synthesis, and X-ray of Selenides as New Class of Agents for Prevention of Diabetic Cerebrovascular Pathology.

C. Supuran, T. Peat, C. Ghelardini, 2018, ACS medicinal chemistry letters.

Structure-based design and development of functionalized Mercaptoguanine derivatives as inhibitors of the folate biosynthesis pathway enzyme 6-hydroxymethyl-7,8-dihydropterin pyrophosphokinase from Staphylococcus aureus.

J. Baell, Zhong-Chang Wang, J. Newman, 2014, Journal of medicinal chemistry.

pyrophosphokinase from Staphylococcus aureus

T. Peat, R. Fernley, J. Simpson, 2010 .

Over the rainbow: structural characterization of the chromoproteins gfasPurple, amilCP, spisPink and eforRed

J. Newman, T. Peat, A. Warden, 2022, Acta Crystallographica Section D: Structural Biology.

Enzyme synthesis and activity assay in microfluidic droplets on a chip

Thomas S. Peat, Fabienne Courtois, Nan Wu, 2011 .

Discovery of a highly potent, selective, orally bioavailable inhibitor of KAT6A/B histone acetyltransferases with efficacy against KAT6A-high ER+ breast cancer.

Chin Wee Tan, Dharmesh D. Bhuva, Eric C Greenwald, 2023, Cell chemical biology.

Determination of the Structure of the Catabolic N-Succinylornithine Transaminase (AstC) from Escherichia coli

Shane A. Seabrook, J. Newman, T. Peat, 2013, PloS one.

Structure of the UmuD′ protein and its regulation in response to DNA damage

E. G. Frank, R. Woodgate, T. Peat, 1996, Nature.

Abstract 5371: PRMT5 inhibitors as novel treatment for cancers

T. Peat, P. Pilling, S. Jane, 2015 .

Unprecedented conformational flexibility revealed in the ligand-binding domains of the Bovicola ovis ecdysone receptor (EcR) and ultraspiracle (USP) subunits.

Shane A. Seabrook, T. Peat, R. Fernley, 2014, Acta crystallographica. Section D, Biological crystallography.

A structural genomics approach to the study of quorum sensing: crystal structures of three LuxS orthologs.

J. M. Sauder, T. Peat, H. Lewis, 2001, Structure.

Structural basis for ligand recognition by a Cache chemosensory domain that mediates carboxylate sensing in Pseudomonas syringae

T. Peat, M. Gerth, James L. O. McKellar, 2016, Scientific Reports.

AFITT- working with good chemistry

T. Peat, J. Christopher, K. Schmidt, 2005 .

X‐Ray Crystallography in Drug Discovery

J. M. Sauder, M. Milburn, T. Peat, 2003 .

HBO1 is required for the maintenance of leukaemia stem cells

Linden J. Gearing, O. Dovey, S. Dawson, 2019, Nature.

A Human Monoclonal Antibody against Insulin-Like Growth Factor-II Blocks the Growth of Human Hepatocellular Carcinoma Cell Lines In vitro and In vivo

E. H. Cohen, J. Newman, T. Peat, 2010, Molecular Cancer Therapeutics.

300-Fold Increase in Production of the Zn2+-Dependent Dechlorinase TrzN in Soluble Form via Apoenzyme Stabilization

M. Field, J. Oakeshott, R. Russell, 2014, Applied and Environmental Microbiology.

Haloalkane dehalogenases: structure of a Rhodococcus enzyme.

J. Newman, T. Peat, T. Terwilliger, 1999, Biochemistry.

The nanoscience behind the art of in-meso crystallization of membrane proteins.

C. Drummond, J. Newman, T. Peat, 2017, Nanoscale.

8-Mercaptoguanine Derivatives as Inhibitors of Dihydropteroate Synthase.

J. Baell, Zhong-Chang Wang, T. Peat, 2018, Chemistry.

Novel Escherichia coli umuD′ Mutants: Structure-Function Insights into SOS Mutagenesis

E. G. Frank, R. Woodgate, T. Peat, 1998, Journal of bacteriology.

Crystal structure of a putrescine aminotransferase from Pseudomonas sp. strain AAC.

J. Newman, T. Peat, C. Scott, 2017, Acta crystallographica. Section F, Structural biology communications.

Fragment screening for a protein-protein interaction inhibitor to WDR5

J. Newman, T. Peat, O. Dolezal, 2019, Structural dynamics.