S. Dakshanamurthy

发表

Drug Metabolism in Preclinical Drug Development: A Survey of the Discovery Process, Toxicology, and Computational Tools.

Sivanesan Dakshanamurthy, Naiem T Issa, Henri Wathieu, 2017, Current drug metabolism.

Functional mimicry of the acetylated C‐terminal tail of p53 by a SUMO‐1 acetylated domain, SAD

S. Dakshanamurthy, Ricardo E. Perez, C. Knights, 2010, Journal of cellular physiology.

Predicting new indications for approved drugs using a proteochemometric method.

Oakland J. Peters, Naiem T. Issa, S. Madhavan, 2012, Journal of medicinal chemistry.

Big data: the next frontier for innovation in therapeutics and healthcare

Sivanesan Dakshanamurthy, Naiem T Issa, Stephen W Byers, 2014, Expert review of clinical pharmacology.

G-DOC: a systems medicine platform for personalized oncology.

Subha Madhavan, Robert Clarke, Louis M Weiner, 2011, Neoplasia.

Differential prioritization of therapies to subtypes of triple negative breast cancer using a systems medicine method

Naiem T. Issa, H. Wathieu, S. Byers, 2017, Oncotarget.

Synthesis and evaluation of hermitamides A and B as human voltage-gated sodium channel blockers.

S. Dakshanamurthy, Kan Wang, M. Paige, 2011, Bioorganic & medicinal chemistry.

Proglumide Reverses Nonalcoholic Steatohepatitis by Interaction with the Farnesoid X Receptor and Altering the Microbiome

S. Dakshanamurthy, B. Kallakury, N. Shivapurkar, 2022, International journal of molecular sciences.

The molecular basis of vitamin D receptor and beta-catenin crossregulation.

J. Welsh, S. Byers, S. Dakshanamurthy, 2006, Molecular cell.

Cancer Preventive Isothiocyanates Induce Selective Degradation of Cellular α- and β-Tubulins by Proteasomes*

S. Dakshanamurthy, A. Cheema, David C. H. Yang, 2009, The Journal of Biological Chemistry.

Activation of estrogen receptor-alpha by the anion nitrite.

S. Dakshanamurthy, M. Martin, Shailaja D. Divekar, 2008, Cancer research.

Large Scale Profiling of SARS-CoV-2-Infected Patients Identified Potential Therapeutic Host Targets and Drug Candidates for COVID-19

S. Dakshanamurthy, Sidhartha Jain, Samantha Rego, 2021 .

Covalent Binding to Tubulin by Isothiocyanates

T. Veenstra, T. Conrads, Zhen Xiao, 2006, Journal of Biological Chemistry.

Priority Report Tumor Suppressor RARRES 1 Interacts with Cytoplasmic Carboxypeptidase AGBL 2 to Regulate the a-Tubulin Tyrosination Cycle

S. Byers, S. Dakshanamurthy, Deepak Kumar, 2011 .

Dramatically reduced surface expression of NK cell receptor KIR2DS3 is attributed to multiple residues throughout the molecule

S. Dakshanamurthy, C. VandenBussche, C. Hurley, 2009, Genes and Immunity.

Ig-Like Receptor 2DL2/2DL3 D1 Domain A Single Polymorphism Disrupts the Killer

S. Dakshanamurthy, C. VandenBussche, C. Hurley, 2006 .

Naturally occurring polyphenol, morin hydrate, inhibits enzymatic activity of N-methylpurine DNA glycosylase, a DNA repair enzyme with various roles in human disease.

S. Vasudevan, S. Dakshanamurthy, V. Yenugonda, 2015, Bioorganic & medicinal chemistry.

Predicting new drug indications for prostate cancer: The integration of an in silico proteochemometric network pharmacology platform with patient‐derived primary prostate cells

S. Byers, S. Dakshanamurthy, Richard J Lee, 2020, The Prostate.

Allelic variation of killer cell immunoglobulin-like receptor 2DS5 impacts glycosylation altering cell surface expression levels.

S. Dakshanamurthy, C. Hurley, N. Steiner, 2014, Human immunology.

SARS-CoV-2 Omicron (BA.1 and BA.2) specific novel CD8+ and CD4+ T cell epitopes targeting spike protein

S. Dakshanamurthy, Simone Parn, K. Savsani, 2022, bioRxiv.

IntegralVac: A Machine Learning-Based Comprehensive Multivalent Epitope Vaccine Design Method

S. Dakshanamurthy, Sadhana Suri, 2022, Vaccines.

The role of calcium in the activation of estrogen receptor-alpha.

S. Dakshanamurthy, Rebecca E. Nakles, M. Martin, 2011, Cancer research.

Cadherin 11 Promotes Immunosuppression and Extracellular Matrix Deposition to Support Growth of Pancreatic Tumors and Resistance to Gemcitabine in Mice.

M. Atkins, S. Byers, S. Dakshanamurthy, 2020, Gastroenterology.

ES-Screen: A Novel Electrostatics-Driven Method for Drug Discovery Virtual Screening

Naiem T. Issa, S. Byers, S. Dakshanamurthy, 2022, International journal of molecular sciences.

Predicting Dose-Range Chemical Toxicity using Novel Hybrid Deep Machine-Learning Method

S. Dakshanamurthy, S. Limbu, C. Zakka, 2022, Toxics.

Small molecule inhibitors of ezrin inhibit the invasive phenotype of osteosarcoma cells

A. Üren, S. Dakshanamurthy, J. Toretsky, 2012, Oncogene.

Asymmetric synthesis of 2,3-dihydro-2-arylquinazolin-4-ones: methodology and application to a potent fluorescent tubulin inhibitor with anticancer activity.

S. Dakshanamurthy, W. Minor, M. Chruszcz, 2008, Journal of medicinal chemistry.

In-silico fragment-based identification of novel angiogenesis inhibitors.

Sivanesan Dakshanamurthy, Stephen W Byers, S. Byers, 2007, Bioorganic & medicinal chemistry letters.

Identification and Characterization of a New Tubulin-Binding Tetrasubstituted Brominated Pyrrole

Jonathan E. Hempel, S. Dakshanamurthy, E. Hamel, 2007, Molecular Pharmacology.

Small molecule selected to disrupt oncogenic protein EWS-FLI1 interaction with RNA Helicase A inhibits Ewing's Sarcoma

A. Üren, S. Dakshanamurthy, O. Abaan, 2009, Nature Medicine.

Cadherin-11 in poor prognosis malignancies and rheumatoid arthritis: common target, common therapies

S. Byers, S. Dakshanamurthy, L. Shapiro, 2013, Oncotarget.

Tumor suppressor RARRES1 interacts with cytoplasmic carboxypeptidase AGBL2 to regulate the α-tubulin tyrosination cycle.

Sivanesan Dakshanamurthy, Ziad J. Sahab, Stephen W Byers, 2011, Cancer research.

Asymmetric synthesis and evaluation of a hydroxyphenylamide voltage-gated sodium channel blocker in human prostate cancer xenografts.

S. Dakshanamurthy, O. McManus, W. Minor, 2012, Bioorganic & medicinal chemistry.

Design, synthesis and discovery of picomolar selective α4β2 nicotinic acetylcholine receptor ligands.

Y. Liu, E. Levin, A. Rezvani, 2013, Journal of medicinal chemistry.

The Molecular Basis of Vitamin D Receptor and β-Catenin Crossregulation

J. Welsh, S. Byers, S. Dakshanamurthy, 2006 .

Fluorescent cyclin-dependent kinase inhibitors block the proliferation of human breast cancer cells.

S. Dakshanamurthy, V. Yenugonda, M. Paige, 2011, Bioorganic & medicinal chemistry.

Mechanisms of Unphosphorylated STAT3 Transcription Factor Binding to DNA*

Valeriy R. Korostyshevskiy, S. Dakshanamurthy, A. Cheema, 2012, The Journal of Biological Chemistry.

A specific missense mutation in GTF2I occurs at high frequency in thymic epithelial tumors

Jaime Rodriguez-Canales, James Gao, Sven Bilke, 2014, Nature Genetics.

Tyrosine-phosphorylated Caveolin-1 (Tyr-14) Increases Sensitivity to Paclitaxel by Inhibiting BCL2 and BCLxL Proteins via c-Jun N-terminal Kinase (JNK)*

S. Dakshanamurthy, R. Clarke, Zachary C. Dobbin, 2012, The Journal of Biological Chemistry.

Allelic Variation in KIR2DL3 Generates a KIR2DL2-like Receptor with Increased Binding to its HLA-C Ligand

S. Dakshanamurthy, C. Hurley, L. Hou, 2013, The Journal of Immunology.

Machine and Deep Learning Approaches for Cancer Drug Repurposing.

Vasileios Stathias, Stephan Schürer, Naiem T Issa, 2020, Seminars in cancer biology.

A small molecule blocking oncogenic protein EWS-FLI1 interaction with RNA helicase A inhibits growth of Ewing’s sarcoma

A. Üren, S. Dakshanamurthy, O. Abaan, 2009 .

Single-Cell and Bulk RNASeq Profiling of COVID-19 Patients Reveal Immune and Inflammatory Mechanisms of Infection-Induced Organ Damage

S. Dakshanamurthy, Yiran Liu, Alexandrea Bass, 2021, Viruses.

Tyrosine Phosphorylation of the Nuclear Receptor Coactivator AIB1/SRC-3 Is Enhanced by Abl Kinase and Is Required for Its Activity in Cancer Cells

Sivanesan Dakshanamurthy, Anton Wellstein, John T. Lahusen, 2008, Molecular and Cellular Biology.

The E3 ubiquitin ligase component, Cereblon, is an evolutionarily conserved regulator of Wnt signaling

Fan Yang, S. Dakshanamurthy, A. Capobianco, 2021, Nature Communications.

Inhibition of cell proliferation by a resveratrol analog in human pancreatic and breast cancer cells

S. Dakshanamurthy, E. Rosen, R. Baruchello, 2009, Experimental & Molecular Medicine.

Drug repurposing a reality: from computers to the clinic

Sivanesan Dakshanamurthy, Naiem T Issa, Stephen W Byers, 2013, Expert review of clinical pharmacology.

Polygamain, a New Microtubule Depolymerizing Agent That Occupies a Unique Pharmacophore in the Colchicine Site

S. Dakshanamurthy, J. Peng, S. Mooberry, 2012, Molecular Pharmacology.

Quinolinol and peptide inhibitors of zinc protease in botulinum neurotoxin A: effects of zinc ion and peptides on inhibition.

Leonard A. Smith, S. Dakshanamurthy, David C. H. Yang, 2009, Archives of biochemistry and biophysics.

G-CODE: enabling systems medicine through innovative informatics

Subha Madhavan, Robert Clarke, Sivanesan Dakshanamurthy, 2011, Genome Biology.

Design of T cell epitope-based vaccine candidate for SARS-CoV-2 targeting nucleocapsid and spike protein escape variants

S. Dakshanamurthy, Samantha Rego, Gabriel Jabbour, 2021, bioRxiv.

“Teaching old drugs to kill new bugs”: structure-based discovery of anti-SARS drugs

N. Pattabiraman, S. Dakshanamurthy, R. Rajnarayanan, 2004, Biochemical and Biophysical Research Communications.

A Single Polymorphism Disrupts the Killer Ig-Like Receptor 2DL2/2DL3 D1 Domain12

S. Dakshanamurthy, C. VandenBussche, C. Hurley, 2006, The Journal of Immunology.

Binding to its HLA-C Ligand KIR 2 DL 2-like Receptor with Increased Allelic Variation in KIR 2 DL 3 Generates a Dakshanamurthy and Carolyn Katovich

S. Dakshanamurthy, C. Hurley, L. Hou, 2013 .

Extracellular domain alterations impact surface expression of stimulatory natural killer cell receptor KIR2DS5

S. Dakshanamurthy, C. VandenBussche, C. Hurley, 2008, Immunogenetics.

Small compounds targeting tyrosine phosphorylation of Scaffold Protein Receptor for Activated C Kinase1A (RACK1A) regulate auxin mediated lateral root development in Arabidopsis

S. Dakshanamurthy, H. Ullah, Shifaa O Alshammari, 2021, Plant signaling & behavior.

Host targeted antiviral (HTA): functional inhibitor compounds of scaffold protein RACK1 inhibit herpes simplex virus proliferation

S. Dakshanamurthy, H. Ullah, Qiyi Tang, 2019, Oncotarget.

ApoE mimetic peptide decreases Aβ production in vitro and in vivo

S. Dakshanamurthy, R. Turner, J. Cirrito, 2010, Molecular Neurodegeneration.

Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism

S. Dakshanamurthy, Sidhartha Jain, M. Policard, 2021, Virus Research.

Design of Peptide Vaccine for COVID19: CD8+ and CD4+ T cell epitopes from SARS-CoV-2 open-reading-frame protein variants

S. Dakshanamurthy, Simone Parn, Gabriel Jabbour, 2021, bioRxiv.

A New Epitope Selection Method: Application to Design a Multi-Valent Epitope Vaccine Targeting HRAS Oncogene in Squamous Cell Carcinoma

S. Dakshanamurthy, K. Savsani, Gabriel Jabbour, 2021, Vaccines.

Evaluating the potential impact of mismatches outside the antigen recognition site in unrelated hematopoietic stem cell transplantation: HLA-DRB1*1454 and DRB1*140101.

C K Hurley, S Dakshanamurthy, S. Dakshanamurthy, 2009, Tissue antigens.

Germ Line Variants of Human N-Methylpurine DNA Glycosylase Show Impaired DNA Repair Activity and Facilitate 1,N6-Ethenoadenine-induced Mutations*

R. Mazumder, A. Üren, S. Dakshanamurthy, 2014, The Journal of Biological Chemistry.

A novel chemo-phenotypic method identifies mixtures of salpn, vitamin D3, and pesticides involved in the development of colorectal and pancreatic cancer

H. Wathieu, S. Byers, S. Dakshanamurthy, 2022, Ecotoxicology and environmental safety.

Histone Deacetylase Cytoplasmic Trapping by a Novel Fluorescent HDAC Inhibitor

S. Dakshanamurthy, M. Jung, A. Dritschilo, 2011, Molecular Cancer Therapeutics.

Predicting Environmental Chemical Carcinogenicity using a Hybrid Machine-Learning Approach

S. Dakshanamurthy, S. Limbu, 2021, bioRxiv.

Discovery Technologies for Drug Repurposing

Sivanesan Dakshanamurthy, Stephen W. Byers, Naiem T. Issa, 2017 .

Retinoic Acid Mediates Regulation of Network Formation by COUP-TFII and VE-Cadherin Expression by TGFβ Receptor Kinase in Breast Cancer Cells

S. Byers, S. Dakshanamurthy, H. Ressom, 2010, PloS one.

Immune characterization and profiles of SARS-CoV-2 infected patients reveals potential host therapeutic targets and SARS-CoV-2 oncogenesis mechanism

S. Dakshanamurthy, Sidhartha Jain, M. Policard, 2021, bioRxiv.

The repurposed anthelmintic mebendazole in combination with trametinib suppresses refractory NRASQ61K melanoma

Emanuel F. Petricoin, Hong-Bin Fang, Sivanesan Dakshanamurthy, 2017, Oncotarget.

Scaffold Protein RACK1 inhibitor compounds prevent the Focal Adhesion Kinase mediated breast cancer cell migration and invasion potential

S. Dakshanamurthy, N. Ahsan, H. Ullah, 2021, bioRxiv.

Harnessing Polypharmacology with Computer-Aided Drug Design and Systems Biology.

H. Wathieu, S. Byers, S. Dakshanamurthy, 2016, Current pharmaceutical design.

Synthesis and biological evaluation of a fluorescent analog of phenytoin as a potential inhibitor of neuropathic pain and imaging agent.

S. Dakshanamurthy, Milton L. Brown, S. Grindrod, 2012, Bioorganic & medicinal chemistry.

RNASeq profiling of COVID19‐infected patients identified an EIF2AK2 inhibitor as a potent SARS‐CoV‐2 antiviral

S. Dakshanamurthy, D. Perlin, Steven Park, 2022, Clinical and translational medicine.

A Peptide Vaccine Design Targeting KIT Mutations in Acute Myeloid Leukemia

S. Dakshanamurthy, K. Savsani, Minji Kim, 2023, Pharmaceuticals.

Indium Titanium Oxide Nanoparticles Induced Hepatic Damage: Hepatoprotective Role of Novel 2-Imino-4-methyl-1, 2-Dihydropyrimido [5, 4C] Quinoline-5(6H)-one

S. Dakshanamurthy, S. Sugumaran, C. Bellan, 2014 .

Predicting Dose-Dependent Carcinogenicity of Chemical Mixtures Using a Novel Hybrid Neural Network Framework and Mathematical Approach

S. Dakshanamurthy, S. Limbu, 2023, Toxics.

RepurposeVS: A Drug Repurposing-Focused Computational Method for Accurate Drug-Target Signature Predictions.

Sivanesan Dakshanamurthy, Naiem T Issa, Stephen W Byers, 2015, Combinatorial chemistry & high throughput screening.

A New Hybrid Neural Network Deep Learning Method for Protein–Ligand Binding Affinity Prediction and De Novo Drug Design

S. Dakshanamurthy, S. Limbu, 2022, International journal of molecular sciences.

Predicting Environmental Chemical Toxicity using a New Hybrid Deep Machine Learning Method

S Limbu, C Zakka, S Dakshanamurthy, 2021 .

Potential of Nurr1 interactions to disclose new Parkinson’s therapeutics

S. Dakshanamurthy, H. Federoff, Milton L. Brown, 2009 .