Jiawang Liu

发表

Insights on Cytochrome P450 Enzymes and Inhibitors Obtained Through QSAR Studies

J. Sridhar, Jiawang Liu, M. Foroozesh, 2012, Molecules.

7-Ethynylcoumarins: selective inhibitors of human cytochrome P450s 1A1 and 1A2.

J. Sridhar, Jiawang Liu, M. Foroozesh, 2012, Chemical research in toxicology.

Toward breast cancer resistance protein (BCRP) inhibitors: design, synthesis of a series of new simplified fumitremorgin C analogues

Ming Zhao, Shiqi Peng, Jiawang Liu, 2007 .

Biocompatible Boron-Containing Prodrugs of Belinostat for the Potential Treatment of Solid Tumors.

Jiawang Liu, Shanchun Guo, Shilong Zheng, 2018, ACS medicinal chemistry letters.

Enzymatic dimerization in the biosynthetic pathway of microbial natural products.

Jiawang Liu, A. Liu, Youcai Hu, 2021, Natural product reports.

Review of Ligand Specificity Factors for CYP1A Subfamily Enzymes from Molecular Modeling Studies Reported to-Date

J. Sridhar, Jiawang Liu, M. Foroozesh, 2017, Molecules.

Rv1075c of Mycobacterium tuberculosis is a GDSL-Like Esterase and is Important for Intracellular Survival.

Jiawang Liu, Ying Kong, S. White, 2019, The Journal of infectious diseases.

Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indole-2-substituted acetates: One-pot-preparation, anti-tumor activity, docking toward DNA and 3D QSAR analysis.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2010, Bioorganic & medicinal chemistry.

Small-molecule inhibitors of Wnt signaling pathway: towards novel anticancer therapeutics.

Jiawang Liu, Yanyuan Wu, Shilong Zheng, 2015, Future medicinal chemistry.

The application of tetrahydroisoquinoline-3-carbonyl-TARGD(F)F as an anti-thrombotic agent having dual mechanisms of action.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2012, Molecular bioSystems.

A joint analysis of metabolomic profiles associated with muscle mass and strength in Caucasian women

Hui Shen, H. Deng, Q. Tian, 2018, Aging.

A review of ceramide analogs as potential anticancer agents.

Jiawang Liu, M. Foroozesh, B. Beckman, 2013, Future medicinal chemistry.

Anticancer targets in the ceramide signaling pathway

Jiawang Liu, M. Foroozesh, B. Beckman, 2010 .

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

J. Sridhar, Jiawang Liu, M. Foroozesh, 2013, Molecules.

Fulvestrant-3 Boronic Acid (ZB716): An Orally Bioavailable Selective Estrogen Receptor Downregulator (SERD).

Jiawang Liu, Shanchun Guo, M. Bratton, 2016, Journal of medicinal chemistry.

Rational Design of a Boron-Modified Triphenylethylene (GLL398) as an Oral Selective Estrogen Receptor Downregulator.

Jiawang Liu, Shanchun Guo, M. Bratton, 2017, ACS medicinal chemistry letters.

Novel functionalized 5-(phenoxymethyl)-1,3-dioxane analogs exhibiting cytochrome P450 inhibition: a patent evaluation WO2015048311 (A1)

J. Sridhar, Jiawang Liu, M. Foroozesh, 2016, Expert opinion on therapeutic patents.

Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis

Ming Zhao, Shiqi Peng, Jiawang Liu, 2015, International journal of nanomedicine.

GLL398, an oral selective estrogen receptor degrader (SERD), blocks tumor growth in xenograft breast cancer models

Jiawang Liu, Shanchun Guo, Madhusoodanan Mottamal, 2020, Breast Cancer Research and Treatment.

Ortho-Methylarylamines as Time-Dependent Inhibitors of Cytochrome P450 1A1 Enzyme.

Kevin E. Riley, J. Sridhar, Jiawang Liu, 2017, Drug metabolism letters.

In silico studies of polyaromatic hydrocarbon inhibitors of cytochrome P450 enzymes 1A1, 1A2, 2A6, and 2B1.

J. Sridhar, Jiawang Liu, M. Foroozesh, 2010, Chemical research in toxicology.

ZB716, a steroidal selective estrogen receptor degrader (SERD), is orally efficacious in blocking tumor growth in mouse xenograft models

M. Ellis, Yong Wu, R. Houtman, 2018, OncoTarget.

Metabolism, pharmacokinetics, and bioavailability of ZB716, a Steroidal Selective Estrogen Receptor Downregulator (SERD)

Jiawang Liu, Shanchun Guo, Shilong Zheng, 2017, Oncotarget.

RGD Peptide and PAD4 Inhibitor-Loaded Gold Nanorods for Chemo-Photothermal Combined Therapy to Inhibit Tumor Growth, Prevent Lung Metastasis and Improve Biosafety

Jiawang Liu, Yuji Wang, Zidong Peng, 2021, International journal of nanomedicine.

Novel anti-viability ceramide analogs: design, synthesis, and structure-activity relationship studies of substituted (S)-2-(benzylideneamino)-3-hydroxy-N-tetradecylpropanamides.

Jiawang Liu, M. Foroozesh, B. Beckman, 2010, Bioorganic & medicinal chemistry.

Metabolomic profiles associated with bone mineral density in US Caucasian women

Ji-Gang Zhang, Hui Shen, H. Deng, 2018, Nutrition & Metabolism.

Nanosized aspirin-Arg-Gly-Asp-Val: delivery of aspirin to thrombus by the target carrier Arg-Gly-Asp-Val tetrapeptide.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2013, ACS nano.

HPLC-MS aided PC12 cell systems: to quantitatively monitor the conversion of nitronyl nitroxide in biological systems with and without NO.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, Molecular bioSystems.

Developing new ceramide analogs and identifying novel sphingolipid controlled genes against a virus-associated lymphoma.

Jungang Chen, Jiawang Liu, M. Foroozesh, 2020, Blood.

A class of novel N-(1-methyl-β-carboline-3-carbonyl)-N'-(aminoacid-acyl)-hydrazines: aromatization leaded design, synthesis, in vitro anti-platelet aggregation/in vivo anti-thrombotic evaluation and 3D QSAR analysis.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, European journal of medicinal chemistry.

Pyrolo[1,2:4,5]‐1,4‐dioxopyrazino[1,2:1,6]pyrido[3,4‐b]indoles: A Group of Urokinase Inhibitors, their Synthesis, and Stereochemistry‐Dependent Activity

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, ChemMedChem.

From Cerius² based stereoview to mouse and enzyme: the model systems for discovery of novel urokinase inhibitors.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, Molecular Biosystems.

Coumarins and P450s, Studies Reported to-Date

J. Sridhar, Jiawang Liu, M. Foroozesh, 2019, Molecules.

Dual-acting agents that possess reversing resistance and anticancer activities: Design, synthesis, MES-SA/Dx5 cell assay, and SAR of Benzyl 1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo[3',4':1,2]pyridin[3,4-b]indol-2-substitutedacetates.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2007, Bioorganic & medicinal chemistry.

2-Substituted (S)-2-(3,3-dimethyl-1-oxo-10,10a-dihydroimidazo[1,5-b]isoquinolin-2(1H,3H,5H)-yl)acetic acids: Conformational prediction, synthesis, anti-thrombotic and vasodilative evaluation.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, Bioorganic & medicinal chemistry.

A class of 3S-2-aminoacyltetrahydro-beta-carboline-3-carboxylic acids: their facile synthesis, inhibition for platelet activation, and high in vivo anti-thrombotic potency.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2010, Journal of medicinal chemistry.

A new class of anti-thrombosis hexahydropyrazino-[1',2':1,6]pyrido-[3,4-b]-indole-1,4-dions: design, synthesis, logK determination, and QSAR analysis.

Ziding Zhang, Ming Zhao, Shiqi Peng, 2007, Bioorganic & medicinal chemistry.

A new platinum-complex showing easy preparation, promising anti-tumor activity, and better efficacy and distribution properties than oxaliplatin.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, Molecular bioSystems.

Gene mining and efficient biosynthesis of a fungal peptidyl alkaloid

Jiawang Liu, Yan-hua Mou, Dao-jiang Yan, 2020, Chinese herbal medicines.

A Ligand-Based Drug Design. Discovery of 4-Trifluoromethyl-7,8-pyranocoumarin as a Selective Inhibitor of Human Cytochrome P450 1A2.

Ming Zhao, Jiawang Liu, M. Foroozesh, 2015, Journal of medicinal chemistry.

Methyl (11aS)-1,2,3,5,11,11a-hexahydro-3,3-dimethyl-1-oxo-6H-imidazo-[3',4':1,2]pyridin[3,4-b]indol-2-substituted acetates: synthesis and three-dimensional quantitative structure-activity relationship investigation as a class of novel vasodilators.

Jun Wang, Shiqi Peng, Ming Zhao, 2008, Journal of medicinal chemistry.

Pyranoflavones: a group of small-molecule probes for exploring the active site cavities of cytochrome P450 enzymes 1A1, 1A2, and 1B1.

Ming Zhao, J. Sridhar, Jiawang Liu, 2013, Journal of medicinal chemistry.

Enzymatic Intermolecular Hetero-Diels-Alder Reaction in the Biosynthesis of Tropolonic Sesquiterpenes.

K. Houk, Jiawang Liu, Dao-jiang Yan, 2019, Journal of the American Chemical Society.

Development of three-component conjugates: to get nano-globes with porous surfaces, high in vivo anti-osteoporosis activity and minimal side effects

Ming Zhao, Shiqi Peng, Jiawang Liu, 2012 .

Synthesis and in vivo lead detoxification evaluation of Poly-α,β-dl-aspartyl-l-methionine.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2012, Chemical research in toxicology.

Novel potassium N-[(2S,3R,4R,5R)-2,3,4,5,6-pentahydroxylhex-1-yl]-L-amino acid dichloroplatinates(II) with high anti-tumor activity and low side reaction.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2012, Metallomics : integrated biometal science.

Identification of Anti-tuberculosis Compounds From Aurone Analogs

Jiawang Liu, C. Jonsson, S. Handy, 2020, Frontiers in Microbiology.

3-Ketone-4,6-diene ceramide analogs exclusively induce apoptosis in chemo-resistant cancer cells.

Ming Zhao, Jiawang Liu, M. Foroozesh, 2014, Bioorganic & medicinal chemistry.

Inhibition of breast tumor growth in mice after treatment with ceramide analog 315

Jiawang Liu, M. Foroozesh, Muralidharan Anbalagan, 2018, Anti-cancer drugs.

Novel d-erythro N-octanoyl sphingosine analogs as chemo- and endocrine-resistant breast cancer therapeutics

Jiawang Liu, M. Foroozesh, B. Beckman, 2010, Cancer Chemotherapy and Pharmacology.

Design, synthesis, and biological activity of a family of novel ceramide analogues in chemoresistant breast cancer cells.

Jiawang Liu, M. Foroozesh, M. Burow, 2009, Journal of medicinal chemistry.

Cytochrome P450 Family 1 Inhibitors and Structure-Activity Relationships

J. Sridhar, Jiawang Liu, M. Foroozesh, 2013, Molecules.

Development of flavone propargyl ethers as potent and selective inhibitors of cytochrome P450 enzymes 1A1 and 1A2.

J. Sridhar, Jiawang Liu, M. Foroozesh, 2013, Drug metabolism letters.

Potent mechanism-based inactivation of cytochrome P450 2B4 by 9-ethynylphenanthrene: implications for allosteric modulation of cytochrome P450 catalysis.

Jiawang Liu, M. Foroozesh, J. Halpert, 2013, Biochemistry.

Inhibition of cytochrome p450 enzymes by quinones and anthraquinones.

J. Sridhar, Jiawang Liu, M. Foroozesh, 2012, Chemical research in toxicology.

EP2 Antagonists (2011-2021): A Decade's Journey from Discovery to Therapeutics.

Jiawang Liu, Jianxiong Jiang, Lexiao Li, 2021, Journal of medicinal chemistry.

Oxidation of pyrene, 1-hydroxypyrene, 1-nitropyrene and 1-acetylpyrene by human cytochrome P450 2A13

H. Yamazaki, Jiawang Liu, M. Foroozesh, 2016, Xenobiotica; the fate of foreign compounds in biological systems.

Associations of Prenatal Metabolomics Profiles with Early Childhood Growth Trajectories and Obesity Risk in African Americans: the CANDLE Study

F. Tylavsky, Jiawang Liu, M. Koçak, 2021, International Journal of Obesity.

Small molecule FGF23 inhibitors increase serum phosphate and improve skeletal abnormalities in Hyp mice

Jeremy C. Smith, Jiawang Liu, Loukas Petridis, 2020, bioRxiv.

A dual-targeting ruthenium nanodrug that inhibits primary tumor growth and lung metastasis via the PARP/ATM pathway

Jiawang Liu, Yuji Wang, Lin Gui, 2021, Journal of Nanobiotechnology.

Fulvestrant-3-Boronic Acid (ZB716) Demonstrates Oral Bioavailability and Favorable Pharmacokinetic Profile in Preclinical ADME Studies

Jiawang Liu, Shanchun Guo, H. Jung, 2021, Pharmaceuticals.

Ethynyl and Propynylpyrene Inhibitors of Cytochrome P450

Jiawang Liu, M. Foroozesh, E. Stevens, 2010, Journal of chemical crystallography.

Ethynylflavones, Highly Potent, and Selective Inhibitors of Cytochrome P450 1A1

Ming Zhao, J. Sridhar, Jiawang Liu, 2014, Chemical research in toxicology.

{2-[1-(3-Methoxycarbonylmethyl-1H-indol-2-yl)-1-methyl-ethyl]-1H-indol-3-yl}-acetic acid methyl ester (MIAM): its anti-cancer efficacy and intercalation mechanism identified via multi-model systems.

Ming Zhao, Shiqi Peng, Jiawang Liu, 2011, Molecular bioSystems.