P. Kirkham

发表

Comprehensive gene expression profiling of rat lung reveals distinct acute and chronic responses to cigarette smoke inhalation.

Christopher S. Stevenson, D. Richardson, C. Stevenson, 2007, American journal of physiology. Lung cellular and molecular physiology.

Transcription factor E2F controls the reversible gamma delta T cell growth arrest mediated through WC1.

E. Lam, P. Kirkham, H. Takamatsu, 1998, Journal of immunology.

Growth arrest of γδ T cells induced by monoclonal antibody against WC1 correlates with activation of multiple tyrosine phosphatases and dephosphorylation of MAP kinase erk2

P. Kirkham, H. Takamatsu, R. Parkhouse, 1997 .

Epigenetics in asthma and other inflammatory lung diseases.

Ian M Adcock, I. Adcock, P. Kirkham, 2010, Epigenomics.

Redox modulation of chromatin remodeling: impact on histone acetylation and deacetylation, NF-kappaB and pro-inflammatory gene expression.

I. Rahman, J. Marwick, P. Kirkham, 2004, Biochemical pharmacology.

Influence of glutathione-S-transferase (GST) inhibition on lung epithelial cell injury: role of oxidative stress and metabolism.

I. Adcock, P. Kirkham, H. Keun, 2015, American journal of physiology. Lung cellular and molecular physiology.

Novel Anti‐Inflammatory Treatments for Asthma and COPD

I. Adcock, K. Chung, P. Kirkham, 2012 .

A B lymphocyte surface molecule mediating activation and protection from apoptosis via calcium channels.

P. Kirkham, R. Parkhouse, L. Santos‐Argumedo, 1993, Journal of immunology.

Murine B-cell activation via CD38 and protein tyrosine phosphorylation.

P. Kirkham, M. Harnett, R. Parkhouse, 1994, Immunology.

Model IgG monoclonal autoantibody-anti-idiotype pair for dissecting the humoral immune response to oxidized low density lipoprotein.

R. Edwards, P. Kirkham, J. Boyle, 2012, Hybridoma.

emphysema after multiple ozone exposures in mice A model of chronic inflammation and pulmonary

K. Chung, P. Kirkham, M. Pinart, 2016 .

A model of chronic inflammation and pulmonary emphysema after multiple ozone exposures in mice.

Min Zhang, I. Adcock, K. Chung, 2011, American journal of physiology. Lung cellular and molecular physiology.

Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Glycogen synthase kinase-3 modulation of glucocorticoid responsiveness in COPD

R. Hoffmann, M. Lindsay, I. Adcock, 2016 .

A role for phosphoinositol 3-kinase delta in the impairment of glucocorticoid responsiveness in patients with chronic obstructive pulmonary disease.

I. Adcock, K. Chung, J. Marwick, 2010, The Journal of allergy and clinical immunology.

A role for PI 3 Kδ in the impairment of glucocorticoid responsiveness in COPD 1 2

I. Adcock, K. Chung, J. Marwick, 2015 .

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

A. Bittner, M. Polkey, I. Adcock, 2015, The Journal of allergy and clinical immunology.

Molecular pathogenesis of cigarette smoking–induced stable COPD

I. Adcock, P. Kirkham, G. Caramori, 2015, Annals of the New York Academy of Sciences.

Ligation of the WC1 Receptor Induces γδ T Cell Growth Arrest Through Fumonisin B1-Sensitive Increases in Cellular Ceramide1

E. Lam, P. Kirkham, H. Takamatsu, 2000, The Journal of Immunology.

A comprehensive analysis of oxidative stress in the ozone-induced lung inflammation mouse model.

I. Adcock, K. Chung, P. Kirkham, 2014, Clinical science.

Strategies for improving the efficacy and therapeutic ratio of glucocorticoids.

I. Adcock, P. Kirkham, G. Caramori, 2012, Current opinion in pharmacology.

Solid-phase immunoglobulins IgG and IgM activate macrophages with solid-phase IgM acting via a novel scavenger receptor a pathway.

P. Kirkham, P. Evans, J. Boyle, 2012, The American journal of pathology.

Evidence That Differences in Fructosamine-3-Kinase Activity May Be Associated With the Glycation Gap in Human Diabetes

A. Nevill, P. Kirkham, S. Dunmore, 2017, Diabetes.

FN3K expression in COPD: a potential comorbidity factor for cardiovascular disease

J. Curtis, I. Adcock, I. Rahman, 2020, BMJ open respiratory research.

Cigarette smoke alters chromatin remodeling and induces proinflammatory genes in rat lungs.

Irfan Rahman, Christopher S. Stevenson, W. MacNee, 2004, American journal of respiratory cell and molecular biology.

Antioxidant therapeutic strategies

I. Rahman, P. Kirkham, 2010 .

Inhibition of PI3Kdelta restores glucocorticoid function in smoking-induced airway inflammation in mice.

Christopher S. Stevenson, I. Adcock, C. Stevenson, 2009, American journal of respiratory and critical care medicine.

Cigarette Smoke‐Induced Oxidative Stress and TGF‐β1 Increase p21waf1/cip1 Expression in Alveolar Epithelial Cells

W. MacNee, I. Rahman, J. Marwick, 2002 .

Cigarette smoke-induced oxidative stress and TGF-beta1 increase p21waf1/cip1 expression in alveolar epithelial cells.

W. MacNee, I. Rahman, J. Marwick, 2002, Annals of the New York Academy of Sciences.

Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

I. Adcock, K. Chung, P. Kirkham, 2016, Journal of Inflammation.

Chemokines and chemokine receptors blockers as new drugs for the treatment of chronic obstructive pulmonary disease.

I. Adcock, K. Chung, P. Kirkham, 2013, Current medicinal chemistry.

Mechanisms of corticosteroid resistance in severe asthma and chronic obstructive pulmonary disease (COPD).

I. Adcock, K. Chung, J. Marwick, 2010, Current pharmaceutical design.

Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells.

I. Adcock, K. Chung, P. Kirkham, 2011, American journal of respiratory cell and molecular biology.

Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of COPD

I. Adcock, K. Chung, P. Kirkham, 2015 .

Pharmacological and dietary antioxidant therapies for chronic obstructive pulmonary disease.

I. Rahman, P. Kirkham, S. Biswas, 2013, Current medicinal chemistry.

PHF11 and DPP10: A Tale of Two Genes in Asthma

I. Adcock, P. Kirkham, 2009, Respiration.

Oxidative stress in asthma and COPD: antioxidants as a therapeutic strategy.

I. Rahman, P. Kirkham, 2006, Pharmacology & therapeutics.

Macrophage phagocytosis of apoptotic neutrophils is compromised by matrix proteins modified by cigarette smoke and lipid peroxidation products.

I. Rahman, P. Kirkham, A. Rossi, 2004, Biochemical and biophysical research communications.

Impact of theophylline/corticosteroid combination therapy on sputum hydrogen sulfide levels in patients with COPD

I. Adcock, K. Chung, P. Kirkham, 2014, European Respiratory Journal.

Porcine CD3ε: its characterization, expression and involvement in activation of porcine T lymphocytes

P. Kirkham, H. Takamatsu, R. Parkhouse, 1996, Immunology.

A γδ T cell specific surface receptor (WC1) signaling G0/G1 cell cycle arrest

P. Kirkham, H. Takamatsu, R. Parkhouse, 1997, European journal of immunology.

Cigarette smoke regulates VEGFR2-mediated survival signaling in rat lungs

Christopher S. Stevenson, W. MacNee, C. Stevenson, 2010, Journal of Inflammation.

Preparation of monoclonal anti‐porcine CD3 antibodies and preliminary characterization of porcine T lymphocytes

P. Kirkham, H. Yang, C. Oura, 1996, Immunology.

Through WC1 T Cell Growth Arrest Mediated d g Reversible Transcription Factor E2F Controls the

P. Kirkham, H. Takamatsu, E. Parkhouse, 1998 .

Identification and characterization of the murine homologue of CD22, a B lymphocyte-restricted adhesion molecule.

P. Kirkham, E. Clark, R. Torres, 1992, Journal of immunology.

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.

P. Chakravarty, I. Rahman, J. Marwick, 2008, American journal of respiratory cell and molecular biology.

Regulation of inflammation and redox signaling by dietary polyphenols.

Irfan Rahman, I. Rahman, P. Kirkham, 2006, Biochemical pharmacology.

A possible overwintering mechanism for bluetongue virus in the absence of the insect vector.

P. Kirkham, P. Mellor, J. Burroughs, 2003, The Journal of general virology.

Analyses of monoclonal antibodies reacting with porcine CD3: results from the Second International Swine CD Workshop.

J. Lunney, J. Nielsen, P. Kirkham, 1998, Veterinary immunology and immunopathology.

Mapping of two new epitopes on the apomucin encoded by MUC5AC gene: Expression in normal GI tract and colon tumors

P. Kirkham, J. Bara, S. Nollet, 2002, International journal of cancer.

Cloning and sequencing of the gene encoding the principal 18-kDa secreted antigen of activated oncospheres of Taenia saginata.

P. Kirkham, R. Parkhouse, T. Garate, 1996, Molecular and biochemical parasitology.

Oxidative stress in COPD.

P. Kirkham, P. Barnes, 2013, Chest.

LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling

I. Adcock, P. Kirkham, M. Yeadon, 2012, Journal of Inflammation.

Edinburgh Research Explorer Cigarette Smoke Exposure Alters mSin3a and Mi-2alpha/beta Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

Christopher S. Stevenson, I. Adcock, K. Chung, 2010 .

Cigarette Smoke Exposure Alters mSin3a and Mi-2α/β Expression; implications in the control of pro-inflammatory gene transcription and glucocorticoid function

Christopher S. Stevenson, I. Adcock, K. Chung, 2010, Journal of Inflammation.

LPS induced inflammatory responses in human peripheral blood mononuclear cells is mediated through NOX4 and Giα dependent PI-3kinase signalling

P. Kirkham, M. Yeadon, K. Meja, 2012, Journal of Inflammation.

Smoking, Oxidative/Carbonyl Stress, and Regulation of Redox Signaling in Lung Inflammation

I. Rahman, P. Kirkham, I. Sundar, 2014 .

Cigarette smoke disrupts VEGF165-VEGFR-2 receptor signaling complex in rat lungs and patients with COPD: morphological impact of VEGFR-2 inhibition.

Christopher S. Stevenson, W. MacNee, C. Stevenson, 2006, American journal of physiology. Lung cellular and molecular physiology.

Autoimmunity and COPD: Clinical Implications

I. Adcock, P. Kirkham, G. Caramori, 2017, Chest.

Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease.

Ian M Adcock, Farhana Hussain, I. Adcock, 2012, American journal of respiratory and critical care medicine.

Brd4 Is Essential for IL-1β-Induced Inflammation in Human Airway Epithelial Cells

I. Adcock, P. Kirkham, P. Barnes, 2014, PloS one.

The measurement of a glycated protein by immunoassay

P. Kirkham, 1989 .

Oxidative stress modulates theophylline effects on steroid responsiveness.

Bernhard Kuster, Probir Chakravarty, Kazuhiro Ito, 2008, Biochemical and biophysical research communications.

Oxidative stress and macrophage function: a failure to resolve the inflammatory response.

P. Kirkham, 2007, Biochemical Society transactions.

Cigarette smoke triggers macrophage adhesion and activation: role of lipid peroxidation products and scavenger receptor.

P. Kirkham, R. Calvez, G. Spooner, 2003, Free radical biology & medicine.

Metabolic re-patterning in COPD airway smooth muscle cells

I. Adcock, K. Chung, P. Kirkham, 2017, European Respiratory Journal.

Oxidative stress and steroid resistance in asthma and COPD: pharmacological manipulation of HDAC-2 as a therapeutic strategy

I. Adcock, J. Marwick, P. Kirkham, 2007, Expert opinion on therapeutic targets.

Research highlights from the 2017 ERS International Congress: airway diseases in focus

M. Idzko, I. Adcock, O. Usmani, 2018, ERJ Open Research.

Mapping of SOMU1 and M1 epitopes on the apomucin encoded by the 5' end of the MUC5AC gene.

P. Kirkham, F. Escande, J. Bara, 2004, Hybridoma and hybridomics.

Transcription Factor E2F Controls the Reversible γδ T Cell Growth Arrest Mediated Through WC1

E. Lam, P. Kirkham, H. Takamatsu, 1998, The Journal of Immunology.

Cellular and molecular features of COVID-19 associated ARDS: therapeutic relevance

P. Kirkham, P. Hansbro, S. Spadaro, 2023, Journal of Inflammation.

Nasal inflammation and its response to local glucocorticoid regular treatment in patients with persistent non-allergic rhinitis: a pilot study

I. Adcock, K. Chung, P. Kirkham, 2016, Journal of Inflammation.

Growth arrest of gammadelta T cells induced by monoclonal antibody against WC1 correlates with activation of multiple tyrosine phosphatases and dephosphorylation of MAP kinase erk2.

P. Kirkham, H. Takamatsu, R. Parkhouse, 1997, European journal of immunology.

Hydrogen sulfide inhibits proliferation and release of IL-8 from human airway smooth muscle cells.

I. Adcock, P. Kirkham, M. Whiteman, 2011, American journal of respiratory cell and molecular biology.

Oxidative stress–induced mitochondrial dysfunction drives inflammation and airway smooth muscle remodeling in patients with chronic obstructive pulmonary disease

A. Bittner, M. Polkey, I. Adcock, 2015, The Journal of allergy and clinical immunology.

Oxidative stress-induced antibodies to carbonyl-modified protein correlate with severity of chronic obstructive pulmonary disease.

I. Adcock, P. Kirkham, P. Barnes, 2012, American journal of respiratory and critical care medicine.

Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2.

P. Chakravarty, I. Rahman, P. Kirkham, 2008, American journal of respiratory cell and molecular biology.

Glycogen synthase kinase-3β modulation of glucocorticoid responsiveness in COPD

N. T. ten Hacken, P. Kirkham, C. Rossios, 2015, American journal of physiology. Lung cellular and molecular physiology.

CALL FOR PAPERS Biomarkers in Lung Diseases: from Pathogenesis to Prediction to New Therapies Glycogen synthase kinase-3 modulation of glucocorticoid responsiveness in COPD

R. Hoffmann, M. Lindsay, I. Adcock, 2016 .

Edinburgh Research Explorer Curcumin restores corticosteroid function in monocytes exposed to oxidants by maintaining HDAC2

P. Chakravarty, P. Kirkham, I. Sundar, 2018 .