J. Nieman

发表

Comprehensive in vitro characterization of PD-L1 small molecule inhibitors

Lai Xu, A. Ganesan, Marawan Ahmed, 2019, Scientific Reports.

HIV Capsid is a Tractable Target for Small Molecule Therapeutic Intervention

J. Nieman, S. Butler, G. Ciaramella, 2010, PLoS pathogens.

Enantioselective synthesis of the pyrroloquinoline core of the martinellines.

J. Nieman, M. D. Ennis, 2000, Organic letters.

HTI-286, a synthetic analogue of the tripeptide hemiasterlin, is a potent antimicrotubule agent that circumvents P-glycoprotein-mediated resistance in vitro and in vivo.

T. Fojo, R. Andersen, J. Nieman, 2003, Cancer research.

Enantioselective synthesis of the pyrroloquinoline core of the martinellines.

J. Nieman, M. D. Ennis, 2000, Organic letters.

Synthesis of 3-methoxycarbonylmethyl derivatives of dihydroquinolone and dihydrochromenone.

J. Nieman, M. D. Ennis, 2001, Journal of Organic Chemistry.

A facile preparation of 2,4-disubstituted furans

J. Nieman, B. A. Keay, 1994 .

Solvent and in situ catalyst preparation impacts upon Noyori reductions of aryl-chloromethyl ketones: application to syntheses of chiral 2-amino-1-aryl-ethanols

J. Nieman, William R. Perrault, Steven E. Heasley, 2006 .

An improved synthesis and resolution of (±)-cis,cis-spiro[4.4]nonane-1,6-diol

J. Nieman, M. Parvez, B. A. Keay, 1993 .

cis,cis-Spiro[4.4]nonane-1,6-diol: A new chiral auxiliary for the asymmetric Diels-Alder reaction

J. Nieman, B. A. Keay, 1996 .

1996 Merck Frosst Award Lecture Synthetic Adventures Along a Rocky Mountain Road

Noel S. Wilson, J. Nieman, S. Maddaford, 1997 .

Synthesis of 3-methoxycarbonylmethyl derivatives of dihydroquinolone and dihydrochromenone.

J. Nieman, M. D. Ennis, 2001, The Journal of organic chemistry.

Synthesis and antimitotic/cytotoxic activity of hemiasterlin analogues.

R. Andersen, J. Nieman, M. Roberge, 2003, Journal of natural products.

An improved synthesis and resolution of (±)-cis,cis-2,2′-spirobiindane-1,1′-diol

J. Nieman, B. A. Keay, 1995 .

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase

J. Nieman, D. Tyrrell, M. Houghton, 2020, J. Chem. Inf. Model..

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

J. Nieman, D. Dalvie, A. Deese, 2008, Drug Metabolism and Disposition.

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

J. Vederas, E. Arutyunova, Justin Shields, 2021, European Journal of Medicinal Chemistry.

Discovery of Ketone-Based Covalent Inhibitors of Coronavirus 3CL Proteases for the Potential Therapeutic Treatment of COVID-19

K. Gajiwala, J. Nieman, K. Ryan, 2020, Journal of medicinal chemistry.

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

J. Vederas, E. Arutyunova, Justin Shields, 2021, Journal of medicinal chemistry.

SARS-CoV-2 Mpro Protease Variants of Concern Display Altered Viral Substrate and Cell Host Target Galectin-8 Processing but Retain Sensitivity toward Antivirals

J. Vederas, E. Arutyunova, M. J. Lemieux, 2023, ACS central science.

SARS-CoV-2 Mpro protease variants of concern display altered viral and host target processing but retain potency towards antivirals

J. Vederas, E. Arutyunova, M. J. Lemieux, 2023, bioRxiv.

Structure-activity relationships of 6-(aminomethylphenoxy)-benzoxaborole derivatives as anti-inflammatory agent.

K. Jarnagin, J. Nieman, Rajeshwar Singh, 2013, Bioorganic & medicinal chemistry letters.

Discovery of a Novel Class of Boron-Based Antibacterials with Activity against Gram-Negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013, Antimicrobial Agents and Chemotherapy.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

J. Vederas, E. Arutyunova, Justin Shields, 2021, RSC medicinal chemistry.

An Efficient Synthesis and Resolution of (±)-cis,cis-Spiro[4.4]nonane-1,6-diol

J. Nieman, B. A. Keay, 1999 .

Inhibition of the hERG potassium ion channel by different non-nucleoside human cytomegalovirus polymerase antiviral inhibitor series and the exploration of variations on a pyrroloquinoline core to reduce cardiotoxicity potential.

Ying Chen, J. Nieman, Z. Gu, 2023, Bioorganic & medicinal chemistry.

Boron‐based phosphodiesterase inhibitors show novel binding of boron to PDE4 bimetal center

K. Jarnagin, J. Nieman, K. R. Maples, 2012, FEBS letters.

with Activity against Gram-negative Bacteria

J. Nieman, S. Cusack, D. Livermore, 2013 .

The Effect of Deuteration and Homologation of the Lactam Ring of Nirmatrelvir on Its Biochemical Properties and Oxidative Metabolism

J. Vederas, E. Arutyunova, Alexandr Belovodskiy, 2023, ACS bio & med chem Au.

Bioactivation of Flutamide Metabolites by Human Liver Microsomes

J. Nieman, D. Dalvie, A. Deese, 2008, Drug Metabolism and Disposition.