D. Tyrrell

D. Tyrrell, N. Kneteman, D. Douglas, 2010, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice

D. Tyrrell, W. Addison, Ran Chen, 2016, PloS one.

TRAIL Inhibits Tumor Growth but Is Nontoxic to Human Hepatocytes in Chimeric Mice

D. Tyrrell, N. Kneteman, Jin H. Song, 2004, Cancer Research.

IFITM1 is a tight junction protein that inhibits hepatitis C virus entry†, ‡

D. Tyrrell, M. Gale, J. McKeating, 2012, Hepatology.

Validation of TaqMan® SNP genotyping specificity for rs12979860 of IL-28B: modeling primer specificity in vitro.

D. Tyrrell, A. Levin, M. Joyce, 2014, Journal of virological methods.

On-Site Viral Inactivation and RNA Preservation of Gargle and Saliva Samples Combined with Direct Analysis of SARS-CoV-2 RNA on Magnetic Beads

X. Le, D. Tyrrell, Hongquan Zhang, 2022, ACS measurement science au.

In Vitro Hepatitis C Virus Infection and Hepatic Choline Metabolism

D. Tyrrell, J. Pezacki, Marc-André Langlois, 2019, bioRxiv.

Prevention of hepatitis C virus infection using a broad cross‐neutralizing monoclonal antibody (AR4A) and epigallocatechin gallate

D. Burton, D. Tyrrell, M. Houghton, 2015, Liver transplantation : official publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society.

Interferons and viruses induce a novel primate-specific isoform dACE2 and not the SARS-CoV-2 receptor ACE2

L. Prokunina-Olsson, D. Tyrrell, S. Boulant, 2020, bioRxiv.

Colonic biopsy in verotoxin-induced hemorrhagic colitis and thrombotic thrombocytopenic purpura (TTP).

D. Tyrrell, L. Jewell, D. M. Morrison, 1986, American journal of clinical pathology.

Quantitative oropharyngeal Epstein-Barr virus shedding in renal and cardiac transplant recipients: relationship to immunosuppressive therapy, serologic responses, and the risk of posttransplant lymphoproliferative disorder.

D. Tyrrell, J. Preiksaitis, F. Mirzayans, 1992, The Journal of infectious diseases.

Molecular cloning, expression and characterization of Pekin duck interferon-λ.

D. Tyrrell, Q. Yao, K. Fischer, 2014, Gene.

Immunotargeting with CD154 (CD40 Ligand) Enhances DNA Vaccine Responses in Ducks

D. Tyrrell, W. Addison, S. Congly, 2006, Clinical and Vaccine Immunology.

Mechanism of inhibition of duck hepatitis B virus polymerase by (-)-beta-L-2',3'-dideoxy-3'-thiacytidine

D. Tyrrell, J. Wilson, A. Severini, 1995, Antimicrobial agents and chemotherapy.

Synthesis and in vitro antiviral activities of 3'-fluoro (or chloro) and 2',3'-difluoro 2',3'-dideoxynucleoside analogs against hepatitis B and C viruses.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2010, Bioorganic & medicinal chemistry.

Identification of cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4) isoforms in the Pekin duck.

D. Tyrrell, B. Motyka, Q. Yao, 2010, Developmental and comparative immunology.

Interferon treatment of multiple pulmonary malignancies associated with papilloma virus.

D. Tyrrell, B. Romanowski, E. Vallières, 2004, Canadian respiratory journal.

Novel 5-vinyl pyrimidine nucleosides with potent anti-hepatitis B virus activity.

D. Tyrrell, R. Kumar, R. Kumar, 2001, Bioorganic & medicinal chemistry letters.

Immunogenicity and protective efficacy of a DNA vaccine encoding a chimeric protein of avian influenza hemagglutinin subtype H5 fused to CD154 (CD40L) in Pekin ducks.

D. Tyrrell, J. Pasick, Y. Berhane, 2010, Vaccine.

Synthesis of 131I, 125I, 123I and 82Br labelled 5-halo-1-(2-deoxy-2-fluoro-β-d-arabinofuranosyl)uracils

D. Tyrrell, H. Misra, L. Wiebe, 1986 .

Lipoprotein profiles in SCID/uPA mice transplanted with human hepatocytes become human-like and correlate with HCV infection success.

D. Tyrrell, N. Kneteman, D. Douglas, 2010, American journal of physiology. Gastrointestinal and liver physiology.

CHARACTERIZATION OF MEASLES VIRUS RNA1

D. Tyrrell, G. Lund, A. Ramsingh, 1984 .

Critical role of natural killer cells in the rejection of human hepatocytes after xenotransplantation into immunodeficient mice

D. Tyrrell, N. Kneteman, D. Douglas, 2010, Transplant international : official journal of the European Society for Organ Transplantation.

Synthesis and antiviral and cytotoxic activity of iodohydrin and iodomethoxy derivatives of 5-vinyl-2'-deoxyuridines, 2'-fluoro-2'-deoxyuridine, and uridine.

D. Tyrrell, T. Allen, L. Wiebe, 1990, Journal of medicinal chemistry.

Synthesis and antiviral activity of IVFRU, a potential probe for the non-invasive diagnosis of herpes simplex encephalitis.

D. Tyrrell, L. Wiebe, T. Iwashina, 1988, Drug design and delivery.

Study of the structure of replicative intermediates of HSV-1 DNA by pulsed-field gel electrophoresis.

D. Tyrrell, A. Severini, A. R. Morgan, 1994, Virology.

Drug-induced porphyrin biosynthesis. V. Effect of protohemin on the transcriptional and post-transcriptional phases of -aminolevulinic acid synthetase induction.

D. Tyrrell, G. S. Marks, 1972, Biochemical pharmacology.

MicroRNAs regulate the immunometabolic response to viral infection in the liver.

Rodney K. Lyn, K. Rayner, D. Tyrrell, 2015, Nature chemical biology.

Progress toward approval of an HCV vaccine.

D. Tyrrell, M. Houghton, M. Logan, 2018, Canadian liver journal.

Murine Models of Hepatitis A Virus Infection.

S. Lemon, D. Tyrrell, M. Joyce, 2019, Cold Spring Harbor perspectives in medicine.

Interferons and viruses induce a novel truncated ACE2 isoform and not the full-length SARS-CoV-2 receptor

L. Prokunina-Olsson, D. Tyrrell, S. Boulant, 2020, Nature Genetics.

Expression of hepatitis C virus-derived core or NS3 antigens in human dendritic cells leads to induction of pro-inflammatory cytokines and normal T-cell stimulation capabilities.

D. Tyrrell, B. Agrawal, Wen Li, 2006, The Journal of general virology.

Interferon production by lymphocytes from multiple sclerosis and non‐MS patients

D. Tyrrell, K. Warren, D. Tovell, 1983, Neurology.

DNA-DNA dot hybridization to detect Epstein-Barr virus in throat washings.

D. Tyrrell, J. Preiksaitis, F. Diaz-Mitoma, 1987, The Journal of infectious diseases.

Efficacy of a Peruvian Botanical Remedy (Sabell A4+) for Treating Liver Disease and Protecting Gastric Mucosal Integrity

J. Wallace, D. Tyrrell, S. Aung, 2019, Evidence-based complementary and alternative medicine : eCAM.

Multicenter comparison of cefoxitin versus cefazolin for prevention of infectious morbidity after nonelective cesarean section.

D. Tyrrell, H. Stiver, M. Lemay, 1983, American journal of obstetrics and gynecology.

Quantitative uptake studies of 131I-labeled (E)-5-(2-iodovinyl)-2'-deoxyuridine in herpes simplex virus-infected cells in vitro

D. Tyrrell, L. Wiebe, J. Samuel, 1984, Antimicrobial Agents and Chemotherapy.

Synthesis and biological properties of (E)-5-(2-[82Br]bromovinyl)-1-(2-deoxy-2-fluoro-β-D-ribofuranosyl)uracil ([82Br]BVFRU)

D. Tyrrell, L. Wiebe, T. Iwashina, 1990 .

Synthesis of 131I, 125I and 82Br labelled (E)-5-(2-halovinyl)-2'-deoxyuridines.

D. Tyrrell, L. Wiebe, J. Samuel, 1984, The International journal of applied radiation and isotopes.

Human serum activates CIDEB-mediated lipid droplet enlargement in hepatoma cells.

Rodney K. Lyn, D. Tyrrell, R. Singaravelu, 2013, Biochemical and biophysical research communications.

Co-incubation with core proteins of HBV and HCV leads to modulation of human dendritic cells.

Amogh Agrawal, D. Tyrrell, S. Samrat, 2014, Viral immunology.

D. Tyrrell, D. Madej, W. P. Gati, 2001 .

Functional changes, increased apoptosis, and diminished nuclear factor-kappaB activity of myeloid dendritic cells during chronic hepatitis C infection.

Justin Shields, D. Tyrrell, Li Zhao, 2010, Human immunology.

Human serum leads to differentiation of human hepatoma cells, restoration of very‐low‐density lipoprotein secretion, and a 1000‐fold increase in HCV Japanese fulminant hepatitis type 1 titers

D. Tyrrell, M. Houghton, M. Joyce, 2013, Hepatology.

A novel method for detection of IFN-lambda 3 binding to cells for quantifying IFN-lambda receptor expression.

D. Tyrrell, M. Houghton, A. Egli, 2017, Journal of immunological methods.

Therapeutic Efficacy of Human Hepatocyte Transplantation in a SCID/uPA Mouse Model with Inducible Liver Disease

D. Tyrrell, N. Kneteman, D. Douglas, 2010, PloS one.

Double-blind placebo-controlled trial of oral acyclovir in first-episode genital herpes simplex virus infection.

D. Richman, D. Tyrrell, C. Critchlow, 1984, JAMA.

An ELISA Based Binding and Competition Method to Rapidly Determine Ligand-receptor Interactions.

D. Tyrrell, M. Houghton, K. Barakat, 2016, Journal of visualized experiments : JoVE.

Detection of duck hepatitis B virus DNA fragments using on-column intercalating dye labeling with capillary electrophoresis-laser-induced fluorescence.

D. Tyrrell, N. Dovichi, W. Tan, 1999, Journal of chromatography. A.

Differential serum levels of eosinophilic eotaxins in primary sclerosing cholangitis, primary biliary cirrhosis, and autoimmune hepatitis.

M. Manns, D. Tyrrell, M. Houghton, 2014, Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research.

In Vitro Infection with Hepatitis B Virus Using Differentiated Human Serum Culture of Huh7.5-NTCP Cells without Requiring Dimethyl Sulfoxide

D. Tyrrell, W. Addison, M. Joyce, 2021, Viruses.

Nucleobase transporter-mediated permeation of 2',3'-dideoxyguanosine in human erythrocytes and human T-lymphoblastoid CCRF-CEM cells.

C. Cass, D. Tyrrell, A. Paterson, 1992, The Journal of biological chemistry.

Enhanced Activation of Memory, but Not Naïve, B Cells in Chronic Hepatitis C Virus-Infected Patients with Cryoglobulinemia and Advanced Liver Fibrosis

D. Tyrrell, M. Houghton, D. Santer, 2013, PloS one.

Evidence for an interaction between the membrane protein of a paramyxovirus and actin

D. Tyrrell, C. Kay, R. M. Giuffre, 1982, Journal of virology.

Structural polypeptides of measles virus.

D. Tyrrell, E. Norrby, 1978, The Journal of general virology.

High levels of Epstein‐Barr virus in the oropharynx: A predictor of disease progression in human immunodeficiency virus infection

D. Tyrrell, B. Romanowski, S. Houston, 1990, Journal of medical virology.

DOUBLE BLIND PLACEBO-CONTROLLED TRIAL OF ORAL ACYCLOVIR IN FIRST EPISODE GENITAL HERPES SIMPLEX VIRUS INFECTION

D. Richman, D. Tyrrell, C. Critchlow, 1985 .

Effect of Different Adjuvants on the Longevity and Strength of Humoral and Cellular Immune Responses to the HCV Envelope Glycoproteins

D. Tyrrell, M. Houghton, B. Akache, 2019, Vaccines.

Half-Life of the Duck Hepatitis B Virus Covalently Closed Circular DNA Pool In Vivo following Inhibition of Viral Replication

K. Walters, D. Tyrrell, W. Addison, 2002, Journal of Virology.

Hepatitis C virus induced up‐regulation of microRNA‐27: A novel mechanism for hepatic steatosis

Rodney K. Lyn, D. Tyrrell, Neda Nasheri, 2014, Hepatology.

No Evidence for XMRV Nucleic Acids, Infectious Virus or Anti-XMRV Antibodies in Canadian Patients with Chronic Fatigue Syndrome

D. Tyrrell, M. Houghton, M. Logan, 2011, PloS one.

The 3rd Canadian Symposium on Hepatitis C Virus: expanding care in the interferon-free era.

D. Tyrrell, M. Houghton, Jennifer F. Raven, 2014, Canadian journal of gastroenterology & hepatology.

Modulation of the metabolism of beta-L-(-)-2',3'-dideoxy-3'-thiacytidine by thymidine, fludarabine, and nitrobenzylthioinosine

D. Tyrrell, J. Rahn, W. P. Gati, 1997, Antimicrobial agents and chemotherapy.

Branched structures in the intracellular DNA of herpes simplex virus type 1

D. Tyrrell, D. Scraba, A. Severini, 1996, Journal of virology.

Rhinofacial zygomycosis caused by Conidiobolus coronatus: a case report including in vitro sensitivity to antimycotic agents.

D. Tyrrell, A. Sekhon, G. Goldsand, 1987, The American journal of tropical medicine and hygiene.

Lamivudine therapy for chronic hepatitis B: a six-month randomized dose-ranging study.

H. Thomas, D. Tyrrell, F. Nevens, 1997, Gastroenterology.

The use of human umbilical cord blood serum is beneficial for the continuous production of hepatitis C virus.

D. Tyrrell, X. Jiao, Rineke Steenbergen, 2016, The Journal of general virology.

N-Terminal Finger Stabilizes the S1 Pocket for the Reversible Feline Drug GC376 in the SARS-CoV-2 Mpro Dimer

J. Vederas, R. McKay, E. Arutyunova, 2021, Journal of Molecular Biology.

N-Terminal finger stabilizes the reversible feline drug GC376 in SARS-CoV-2 Mpro

J. Vederas, R. McKay, E. Arutyunova, 2021, bioRxiv.

Plasmodium falciparum infection and exoerythrocytic development in mice with chimeric human livers.

J. Sacci, U. Alam, A. Azad, 2006, International journal for parasitology.

Structure-Activity Relationship of a New Class of Anti-Hepatitis B Virus Agents

R. Dwek, K. Walters, D. Tyrrell, 2002, Antimicrobial Agents and Chemotherapy.

Mutation in HBV RNA‐dependent DNA polymerase confers resistance to lamivudine in vivo

D. Tyrrell, N. Kneteman, G. Tipples, 1996, Hepatology.

Antiviral activity of various 1-(2'-deoxy-β-D-lyxofuranosyl), 1-(2'-fluoro-β-D-xylofuranosyl), 1-(3'-fluoro-β-D-arabinofuranosyl), and 2'-fluoro-2',3'-didehydro-2',3'-dideoxyribose pyrimidine nucleoside analogues against duck hepatitis B virus (DHBV) and human hepatitis B virus (HBV) replication.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2010, Journal of medicinal chemistry.

Design and synthesis of novel 5-substituted acyclic pyrimidine nucleosides as potent and selective inhibitors of hepatitis B virus.

D. Tyrrell, Rakesh Kumar, M. Nath, 2002, Journal of medicinal chemistry.

A new class of pyrimidine nucleosides: inhibitors of hepatitis B and C viruses.

D. Tyrrell, S. Vedi, Rakesh Kumar, 2012, Bioorganic & medicinal chemistry letters.

Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2010, Bioorganic & medicinal chemistry letters.

Inhibition of hepatitis B virus (HBV) replication by pyrimidines bearing an acyclic moiety: effect on wild-type and mutant HBV.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2006, Journal of medicinal chemistry.

Quantitative hepatitis B virus DNA assessment by the limiting‐dilution polymerase chain reaction in chronic hepatitis B patients: evidence of continuing viral suppression with longer duration and higher dose of lamivudine therapy

H. Thomas, D. Tyrrell, F. Nevens, 1998, Journal of viral hepatitis.

Synthesis and antiviral activity of novel acyclic nucleoside analogues of 5-(1-azido-2-haloethyl)uracils.

D. Tyrrell, H. Saffran, N. Sharma, 2001, Journal of medicinal chemistry.

A Refined Model of the HCV NS5A Protein Bound to Daclatasvir Explains Drug-Resistant Mutations and Activity against Divergent Genotypes

Jack A. Tuszynski, Khaled H. Barakat, D. Lorne Tyrrell, 2015, J. Chem. Inf. Model..

Synthesis, Transformation Chemistry, and Biological Activity of Guanine Nucleosides and Analoges

M. J. Robins, D. Tyrrell, F. Hansske, 1989 .

Effect of various pyrimidines possessing the 1-[(2-hydroxy-1-(hydroxymethyl)ethoxy)methyl] moiety, able to mimic natural 2'-deoxyribose, on wild-type and mutant hepatitis B virus replication.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2006, Journal of medicinal chemistry.

Mycoplasma hominis septicemia in a burned infant.

D. Tyrrell, M. Dan, J. Robertson, 1981, The Journal of pediatrics.

Saikosaponin b2 is a naturally occurring terpenoid that efficiently inhibits hepatitis C virus entry.

Justin Shields, D. Tyrrell, Chun-ching Lin, 2015, Journal of hepatology.

Comparative cervical microflora shifts after cefoxitin or cefazolin prophylaxis against infection following cesarean section.

D. Tyrrell, H. Stiver, M. Lemay, 1984, American journal of obstetrics and gynecology.

A computational approach for predicting off-target toxicity of antiviral ribonucleoside analogues to mitochondrial RNA polymerase

J. Tuszynski, D. Tyrrell, M. Houghton, 2018, The Journal of Biological Chemistry.

Application of Molecular Dynamics Simulations to the Design of Nucleotide Inhibitors Binding to Norovirus Polymerase

J. Nieman, D. Tyrrell, M. Houghton, 2020, J. Chem. Inf. Model..

Superinfection Exclusion in Duck Hepatitis B Virus Infection Is Mediated by the Large Surface Antigen

K. Walters, D. Tyrrell, W. Addison, 2004, Journal of Virology.

Listeria monocytogenes endophthalmitis in an immune-suppressed host.

D. Tyrrell, F. L. Jackson, J. Nigrin, 1977, Canadian Medical Association journal.

Topical undecylenic acid for herpes simplex labialis: a multicenter, placebo-controlled trial.

F. Aoki, D. Tyrrell, M. Gill, 1997, The Journal of infectious diseases.

Actin filaments in paramyxovirus-infected human fibroblasts studied by indirect immunofluorescence

D. Tyrrell, E. Norrby, R. Norberg, 2005, Archives of Virology.

Chimeric rodents with humanized liver: bridging the preclinical/clinical trial gap in ADME/toxicity studies

D. Tyrrell, N. Kneteman, G. Lund, 2014, Xenobiotica; the fate of foreign compounds in biological systems.

Improved SARS-CoV-2 Mpro inhibitors based on feline antiviral drug GC376: Structural enhancements, increased solubility, and micellar studies

J. Vederas, E. Arutyunova, Justin Shields, 2021, European Journal of Medicinal Chemistry.

Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

D. Lorne Tyrrell, John C. Vederas, Ryan T. McKay, 2020, Nature Communications.

A Hepatitis C Virus (HCV) Vaccine Comprising Envelope Glycoproteins gpE1/gpE2 Derived from a Single Isolate Elicits Broad Cross-Genotype Neutralizing Antibodies in Humans

Christopher T. Jones, C. Rice, J. Bukh, 2013, PloS one.

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine

K. Walters, D. Tyrrell, G. Tipples, 1998 .

Identification and characterization of mutations in hepatitis B virus resistant to lamivudine. Lamivudine Clinical Investigation Group.

K. Walters, D. Tyrrell, G. Tipples, 1998, Hepatology.

Postliver transplant allograft reinfection with a lamivudine-resistant strain of hepatitis B virus: long-term follow-up.

D. Tyrrell, N. Kneteman, E. Yoshida, 1998, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

Phase II trial of lamivudine for chronic hepatitis B

D. Tyrrell, 1993 .

In vitro antiviral activities of myristic acid analogs against human immunodeficiency and hepatitis B viruses.

K. Parang, D. Tyrrell, F. Csizmadia, 1997, Antiviral research.

In vitro and in vivo comparison of the abilities of purine and pyrimidine 2',3'-dideoxynucleosides to inhibit duck hepadnavirus

D. Tyrrell, W. Luo, S. Suzuki, 1989, Antimicrobial Agents and Chemotherapy.

Generation of duck hepatitis B virus polymerase mutants through site-directed mutagenesis which demonstrate resistance to lamivudine [(--)-beta-L-2', 3'-dideoxy-3'-thiacytidine] in vitro

D. Tyrrell, K. Fischer, 1996, Antimicrobial agents and chemotherapy.

Inhibition of duck hepatitis B virus replication by purine 2',3'-dideoxynucleosides.

D. Tyrrell, W. Luo, S. Suzuki, 1988, Biochemical and biophysical research communications.

Intracellular metabolism of 2',3'-dideoxynucleosides in duck hepatocyte primary cultures.

D. Tyrrell, T. E. Kitos, 1995, Biochemical pharmacology.

Efficacy of lamivudine in chronic hepatitis B patients with active viral replication and decompensated cirrhosis undergoing liver transplantation.

D. Tyrrell, N. Kneteman, L. Jewell, 1996, Transplantation.

Lamivudine results in a complete and sustained suppression of hepatitis B virus replication in patients requiring orthotopic liver transplantation for cirrhosis secondary to hepatitis B

D. Tyrrell, N. Kneteman, G. Tipples, 1995 .

(-)-beta-L-2',3'-dideoxy-3'-thiacytidine. virus polymerase by Mechanism of inhibition of duck hepatitis B

D. Tyrrell, J. Wilson, A. Severini, 2013 .

A quantitative competitive PCR assay for the covalently closed circular form of the duck hepatitis B virus.

D. Tyrrell, W. Addison, W. Wong, 2000, Antiviral research.

An in vitro system for the enzymological analysis of avian hepatitis B virus replication and inhibition in core particles.

D. Tyrrell, S. Urban, 2000, Antiviral research.

In vitro anti-hepatitis B virus activities of 5"-O-myristoyl analogue derivatives of 3"-fluoro-2",3"-dideoxythymidine (FLT) and 3"-azido-2",3"-dideoxythymidine (AZT).

K. Parang, D. Tyrrell, L. Wiebe, 1998, Journal of pharmacy & pharmaceutical sciences : a publication of the Canadian Society for Pharmaceutical Sciences, Societe canadienne des sciences pharmaceutiques.

Expression of an enzymatically active polymerase of human hepatitis B virus in an coupled transcription-translation system.

D. Tyrrell, Z. Li, 1999, Biochemistry and cell biology = Biochimie et biologie cellulaire.

Clinical course of recurrent genital herpes and treatment with foscarnet cream: results of a Canadian multicenter trial.

F. Aoki, D. Tyrrell, W. Schlech, 1987, The Journal of infectious diseases.

Duck hepatitis B virus polymerase acts as a suppressor of core protein translation

D. Tyrrell, A. Howe, 1996, Journal of virology.

Enhancement of T helper type 1 immune responses against hepatitis B virus core antigen by PLGA nanoparticle vaccine delivery.

John Samuel, D. Tyrrell, G. Kwon, 2005, Journal of controlled release : official journal of the Controlled Release Society.

Pharmacokinetics and metabolism of E-5-(2-[131I]iodovinyl)-2'-deoxyuridine in dogs

D. Tyrrell, L. Wiebe, J. Samuel, 1986, Antimicrobial Agents and Chemotherapy.

Efficient pyrophosphorolysis by a hepatitis B virus polymerase may be a primer-unblocking mechanism

D. Tyrrell, S. Urban, K. Fischer, 2001, Proceedings of the National Academy of Sciences of the United States of America.

Detailed Computational Study of the Active Site of the Hepatitis C Viral RNA Polymerase to Aid Novel Drug Design

Jack A. Tuszynski, John Law, Khaled H. Barakat, 2013, J. Chem. Inf. Model..

Effect of liver disease on pharmacokinetics and toxicity of 9-beta-D-arabinofuranosyladenine-5-phosphate.

D. Tyrrell, J. Preiksaitis, G. Lepage, 1981, The Journal of infectious diseases.

Synthesis of 5-[1-hydroxy(or methoxy)-2-bromo(or chloro)ethyl]-2'-deoxyuridines and related halohydrin analogues with antiviral and cytotoxic activity.

D. Tyrrell, T. Allen, L. Wiebe, 1989, Journal of medicinal chemistry.

CRISPR-Cas9 gene editing of hepatitis B virus in chronically infected humanized mice

J. Sagartz, D. Tyrrell, L. Corey, 2020, Molecular therapy. Methods & clinical development.

Anti‐HCV therapies in chimeric scid‐Alb/uPA mice parallel outcomes in human clinical application

Z. Ni, D. Tyrrell, A. Weiner, 2006, Hepatology.

Duck hepatitis B virus polymerase produced by in vitro transcription and translation possesses DNA polymerase and reverse transcriptase activities.

D. Tyrrell, J. Elliott, A. Howe, 1992, Biochemical and biophysical research communications.

Application of the trak-C HCV core assay for monitoring antiviral activity in HCV replication systems.

R. Bartenschlager, D. Tyrrell, T. Pietschmann, 2004, Journal of virological methods.

Therapy for recurrent herpetic whitlow.

D. Tyrrell, M. Gill, J. Arlette, 1986, Annals of internal medicine.

The impact of the interferon-lambda family on the innate and adaptive immune response to viral infections

D. Tyrrell, M. Houghton, A. Egli, 2014, Emerging Microbes & Infections.

Synthesis and antiviral activity of novel 5-(1-cyanamido-2-haloethyl) and 5-(1-hydroxy(or methoxy)-2-azidoethyl) analogues of uracil nucleosides.

D. Tyrrell, H. Saffran, S. Sharma, 2001, Journal of medicinal chemistry.

Antibodies to measles virus surface polypeptides in an immunized student population before and after booster vaccination.

M. Mäkelä, D. Tyrrell, E. Norrby, 1989, Vaccine.

Host-Specific Response to HCV Infection in the Chimeric SCID-beige/Alb-uPA Mouse Model: Role of the Innate Antiviral Immune Response

M. Katze, K. Walters, S. Proll, 2006, PLoS pathogens.

Hcmv‐miR‐UL22A‐5p: A Biomarker in Transplantation With Broad Impact on Host Gene Expression and Potential Immunological Implications

D. Tyrrell, A. Åsberg, H. Rollag, 2015, American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons.

CRISPR technology incorporating amplification strategies: molecular assays for nucleic acids, proteins, and small molecules†

X. Le, Juan Li, D. Tyrrell, 2021, Chemical science.

Modified apoptotic molecule (BID) reduces hepatitis C virus infection in mice with chimeric human livers

D. Tyrrell, J. Ruland, N. Kneteman, 2003, Nature Biotechnology.

Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.

John Paul Pezacki, Shao Yao, Pengyu Yang, 2013, Chemistry & biology.

Ultrasonography to diagnose testicular lesions in infertile Angora buck

D. Tyrrell, G. Odiawo, G. Agumbah, 1995 .

Course of herpes zoster.

D L Tyrrell, D. Tyrrell, 1984, Canadian Medical Association journal.

Drug-induced porphyrin biosynthesis—IV

D. Tyrrell, G. S. Marks, 1972 .

Drug-induced porphyrin biosynthesis. 3. Inhibition of drug-induced porphyria by protohemin.

D. Tyrrell, G. S. Marks, D. Schneck, 1971, Biochemical pharmacology.

IL-28B is a Key Regulator of B- and T-Cell Vaccine Responses against Influenza

M. Battegay, D. Tyrrell, M. Houghton, 2014, PLoS pathogens.

Immunomodulatory Function of Interleukin 28B during primary infection with cytomegalovirus.

D. Tyrrell, M. Houghton, K. Barakat, 2014, The Journal of infectious diseases.

The molecular length of measles virus RNA and the structural organization of measles nucleocapsids.

D. Tyrrell, G. Lund, R. Bradley, 1984, The Journal of general virology.

HCV Induces Oxidative and ER Stress, and Sensitizes Infected Cells to Apoptosis in SCID/Alb-uPA Mice

M. Katze, K. Walters, G. McFadden, 2009, PLoS pathogens.

Hepatitis C Virus Envelope Glycoprotein Fitness Defines Virus Population Composition following Transmission to a New Host

S. Réhman, P. Borrow, A. Tarr, 2012, Journal of Virology.

New Host Composition following Transmission to a Fitness Defines Virus Population Hepatitis C Virus Envelope Glycoprotein

P. Borrow, A. Tarr, J. Ball, 2012 .

Reductions in circulating levels of IL-16, IL-7 and VEGF-A in myalgic encephalomyelitis/chronic fatigue syndrome.

D. Tyrrell, M. Houghton, D. Broadhurst, 2016, Cytokine.

DNase-mediated single-cycle selection of aptamers for proteins blotted on a membrane.

X Chris Le, Feng Li, X. Le, 2012, Analytical chemistry.

Author Correction: Feline coronavirus drug inhibits the main protease of SARS-CoV-2 and blocks virus replication

J. Vederas, R. McKay, E. Arutyunova, 2020, Nature Communications.

Peptidomimetic α-Acyloxymethylketone Warheads with Six-Membered Lactam P1 Glutamine Mimic: SARS-CoV-2 3CL Protease Inhibition, Coronavirus Antiviral Activity, and in Vitro Biological Stability

J. Vederas, E. Arutyunova, Justin Shields, 2021, Journal of medicinal chemistry.

The Second Canadian Symposium on hepatitis C virus: a call to action.

D. Tyrrell, M. Houghton, Jennifer F. Raven, 2013, Canadian journal of gastroenterology = Journal canadien de gastroenterologie.

Differential expression of interferon-lambda receptor 1 splice variants determines the magnitude of the antiviral response induced by interferon-lambda 3 in human immune cells

S. Elahi, D. Tyrrell, M. Houghton, 2020, PLoS pathogens.

Application of functional genomics to the chimeric mouse model of HCV infection: optimization of microarray protocols and genomics analysis

M. Katze, K. Walters, S. Proll, 2006, Virology Journal.

Hepatitis C virus and microRNAs: miRed in a host of possibilities.

D. Tyrrell, R. Singaravelu, J. Pezacki, 2014, Current opinion in virology.

Activity-based Protein Profiling Identifies a Host Enzyme, Carboxylesterase 1, Which Is Differentially Active during Hepatitis C Virus Replication*

Rodney K. Lyn, D. Tyrrell, A. Stolow, 2010, The Journal of Biological Chemistry.

Antibodies to neutralising epitopes synergistically block the interaction of the receptor‐binding domain of SARS‐CoV‐2 to ACE 2

C. Day, D. Tyrrell, Manisha Pandey, 2021, Clinical & translational immunology.

Isolation and immunological characterization of the nucleocapsid and membrane proteins of measles virus.

D. Tyrrell, E. Norrby, C. Orvell, 1980, The Journal of general virology.

The Hepatitis C Virus-Induced Membranous Web and Associated Nuclear Transport Machinery Limit Access of Pattern Recognition Receptors to Viral Replication Sites

K. Kirkegaard, D. Tyrrell, R. Wozniak, 2016, PLoS pathogens.

Establishing normal metabolism and differentiation in hepatocellular carcinoma cells by culturing in adult human serum

R. ter Horst, M. Oti, Alexandr Belovodskiy, 2018, Scientific Reports.

Integrating Reverse Transcription Recombinase Polymerase Amplification with CRISPR Technology for the One-Tube Assay of RNA.

K. Pabbaraju, X. Le, D. Tyrrell, 2021, Analytical chemistry.

Idiopathic colitis associated with scrotal cellulitis.

D. Tyrrell, L. Jewell, A. Thomson, 1979, The Journal of pediatrics.

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

J. Tuszynski, D. Tyrrell, M. Houghton, 2021, BMC Pharmacology and Toxicology.

Sensitive luminescent reporter viruses reveal appreciable release of hepatitis C virus NS5A protein into the extracellular environment.

D. Tyrrell, M. Joyce, A. Aloia, 2017, Virology.

Functional Characterization of Nuclear Localization and Export Signals in Hepatitis C Virus Proteins and Their Role in the Membranous Web

D. Tyrrell, R. Wozniak, C. Neufeldt, 2014, PloS one.

Hepatitis C Virus-Induced Cytoplasmic Organelles Use the Nuclear Transport Machinery to Establish an Environment Conducive to Virus Replication

Justin Shields, D. Tyrrell, R. Wozniak, 2013, PLoS pathogens.

Transmembrane communication in cells chronically infected with measles virus

D. Tyrrell, A. Ehrnst, 1979, The Journal of cell biology.

HCV and flaviviruses hijack cellular mechanisms for nuclear STAT2 degradation: Up-regulation of PDLIM2 suppresses the innate immune response

D. Tyrrell, T. Hobman, W. Addison, 2019, PLoS pathogens.

Peptidomimetic nitrile warheads as SARS-CoV-2 3CL protease inhibitors.

J. Vederas, E. Arutyunova, Justin Shields, 2021, RSC medicinal chemistry.

Molecular cloning, expression and characterization of Pekin duck programmed death-1.

D. Tyrrell, Q. Yao, K. Fischer, 2019, Gene.

Seroepidemiology of Hepatitis C Among Drug Users at a Detoxification Center in Southeast China

D. Tyrrell, M. Houghton, Xubin Zhang, 2020, Hepatitis Monthly.

Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses

D. Tyrrell, R. Epand, R. Epand, 2010, Proceedings of the National Academy of Sciences.

Hypothesis: Chronic Benign Daily Headache is an Immune Disorder with a Viral Trigger

D. Tyrrell, F. Diaz-Mitoma, W. Vanast, 1987, Headache.

Differential Impact of SARS-CoV-2 Isolates, Namely, the Wuhan Strain, Delta, and Omicron Variants on Erythropoiesis

S. Elahi, D. Tyrrell, W. Sligl, 2022, Microbiology spectrum.

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Michael Houghton, Jack A Tuszynski, Sergei Y Noskov, 2014, Toxicology letters.

The cell biology of hepatitis C virus.

D. Tyrrell, M. Joyce, D. L. Tyrrell, 2010, Microbes and infection.

Peginterferon-lambda for the treatment of COVID-19 in outpatients

J. Glenn, D. Tyrrell, Deepali Kumar, 2020, medRxiv.

Rational Drug Design: One Target, Many Paths to It

Jack A. Tuszynski, Khaled H. Barakat, D. Lorne Tyrrell, 2014, Int. J. Comput. Model. Algorithms Medicine.

Role of the E2 Hypervariable Region (HVR1) in the Immunogenicity of a Recombinant Hepatitis C Virus Vaccine

D. Tyrrell, M. Houghton, E. Dudek, 2018, Journal of Virology.

Investigating the antiviral role of cell death‐inducing DFF45‐like effector B in HCV replication

Rodney K. Lyn, D. Tyrrell, R. Singaravelu, 2014, The FEBS journal.

Glycogen synthase kinase 3β inhibitors prevent hepatitis C virus release/assembly through perturbation of lipid metabolism

D. Tyrrell, M. Houghton, A. Mason, 2017, Scientific Reports.

Computational determination of toxicity risks associated with a selection of approved drugs having demonstrated activity against COVID-19

J. Tuszynski, D. Tyrrell, M. Houghton, 2021, BMC pharmacology & toxicology.

Multiplex Assays Enable Simultaneous Detection and Identification of SARS-CoV-2 Variants of Concern in Clinical and Wastewater Samples

X. Le, D. Tyrrell, X. Pang, 2023, ACS Measurement Science Au.

Electrophoresis of immunoglobulin G. Facilitated migration of minute amounts in agarose.

D. Tyrrell, E. Norrby, M. Weil, 1978, Journal of immunological methods.

CRISPR Technique Incorporated with Single-Cell RNA Sequencing for Studying Hepatitis B Infection.

X. Le, D. Tyrrell, Joaquin Lopez-Orozco, 2021, Analytical chemistry.

Bovine Serum Albumin-Protected Gold Nanoclusters for Sensing of SARS-CoV-2 Antibodies and Virus.

D. Tyrrell, M. Houghton, M. Logan, 2023, ACS applied materials & interfaces.

The in vitro evaluation of nucleoside analogues as probes for use in the noninvasive diagnosis of herpes simplex encephalitis.

D. Tyrrell, H. Misra, L. Wiebe, 1988, Drug design and delivery.

Utilization of a Glucometer Test Strip and Enzymatic Reactions to Quantify Anti-SARS-CoV-2 Spike RBD IgG Antibody and SARS-CoV-2 Virus in Saliva and Serum

D. Tyrrell, M. Houghton, M. Logan, 2023, Analytical chemistry.

Growth of bacterial biofilms on Tenckhoff catheter discs in vitro after simulated touch contamination of the Y-connecting set in continuous ambulatory peritoneal dialysis.

D. Tyrrell, J. Costerton, M. Dasgupta, 1990, American journal of nephrology.

Treatment of Recurrent Genital Herpes Simplex Infections with Oral Acyclovir. A Controlled Trial

G. Badger, D. Richman, D. Tyrrell, 1984 .

Meningitis complicating transsphenoidal hypophysectomy.

D. Tyrrell, B. Romanowski, G. Goldsand, 1981, Canadian Medical Association journal.

Aptamer binding assay for the E antigen of Hepatitis B using modified aptamers with G-quadruplex structures.

X. Le, D. Tyrrell, Xing-Fang Li, 2020, Analytical chemistry.

Inhibition of viral transcription using designed zinc finger proteins.

D. Tyrrell, Kimberley A Hoeksema, 2010, Methods in molecular biology.

Challenge Inoculum for Hepatitis C Virus Controlled Human Infection Model.

J. Bukh, T. Liang, S. Ray, 2023, Clinical infectious diseases : an official publication of the Infectious Diseases Society of America.

Modulation of fatty acid synthase enzyme activity and expression during hepatitis C virus replication.

D. Tyrrell, S. Yao, Neda Nasheri, 2013, Chemistry & biology.

Synthesis and evaluation of {125I}‐(E)‐5‐(2‐iodovinyl)‐N3‐methyl‐2′‐deoxy‐uridine as a potential probe for the non‐invasive diagnosis of herpes simplex encephalitis

D. Tyrrell, L. Wiebe, M. Tandon, 1989 .

Paramyxovirus membrane protein enhances antibody production to new antigenic determinants in the actin molecule: a model for virus-induced autoimmunity

D. Tyrrell, D. Tovell, W. Anomasiri, 1990, Journal of virology.

Antiviral activity of 2,3'-anhydro and related pyrimidine nucleosides against hepatitis B virus.

D. Tyrrell, Rakesh Kumar, B. Agrawal, 2010, Bioorganic & medicinal chemistry letters.